Designing nanoparticles for biological environments: from quantum sensing to gene medicine

Date:
20
Monday
May
2024
Colloquia
Time: 11:00-12:15
Location: Gerhard M.J. Schmidt Lecture Hall
Lecturer: Prof. Petr Cigler
Organizer: Department of Chemical and Biological Physics
Contact: sarah.amzallag@weizmann.ac.il
Details: Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences
Abstract: The use of nanoparticles in diagnostics, therapeutics and imaging has revolution ... Read more The use of nanoparticles in diagnostics, therapeutics and imaging has revolutionized these fields with new properties not available with small molecules. Nanoparticle interface provide possibilities for polyvalent and independent attachment of different molecules serving as recognition/targeting structures, optical probes, spin probes or catalysts. However, nanoparticles operating in biological environments require precise control of multiple factors related to surface chemistry and their composition. To avoid for example aggregation, off-target interactions, and protein corona formation, appropriate interface design is essential. This talk will present general nanoparticle design strategies and specific examples including nanodiamonds and lipid nanoparticles.
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