3D quantitative-amplified Magnetic Resonance Imaging (3D q-aMRI)
Date:
Lecture / Seminar
Time: 16:30-17:30
Location: Perlman Chemical Sciences Building
Lecturer: Itamar Terem
Organizer: Clore Institute for High-Field Magnetic Resonance Imaging and Spectroscopy
Details: Electrical Engineering Department, Stanford University
Abstract: Changes in blood vessel pulsation and cerebrospinal fluid dynamics cause cyclic ... Read more Changes in blood vessel pulsation and cerebrospinal fluid dynamics cause cyclic deformation of the brain, which can be altered by neurological pathologies. Various MRI techniques are available to visualize and quantify pulsatile brain motion, but they have limitations. Amplified MRI (aMRI) is a promising new technique that can visualize pulsatile brain tissue motion by amplifying sub-voxel motion in cine MRI data, but it lacks the ability to quantify the sub-voxel motion field in physical units. Here a novel 3D quantitative aMRI (3D q-aMRI) post-processing algorithm is introduced that can visualize and quantify pulsatile brain motion. To validate the algorithm, we tested it on a 3D digital phantom and on healthy volunteers. We also acquired preliminary data on participants with Alzheimer's disease and healthy aging controls. The results show that 3D q-aMRI can accurately quantify sub-voxel motion (of 0.005 pixel size) and has potential diagnostic value in identifying disease-induced biomechanical differences.Close abstract
