Modulation of T-cell activity by the human T-cell leukemia virus fusion peptide

Date:
30
Tuesday
April
2019
Lecture / Seminar
Time: 10:00-10:30
Location: Nella and Leon Benoziyo Building for Biological Sciences
Lecturer: Eita Rotem
Organizer: Department of Biomolecular Sciences
Details: Department of Biomolecular Sciences-WIS
Abstract: In order to infect and persist in their hosts, viruses utilize multiple strategi ...In order to infect and persist in their hosts, viruses utilize multiple strategies to evade the immune system. HIV utilizes membrane interacting regions of its envelope protein, primarily used to fuse with its target cells, to inhibit T-cell activation. Yet, it is unknown whether this ability is shared with other viruses. We examined the T-cell inhibitory activity of HTLV-1, focusing on a functionally conserved region of HTLV’s and HIV’s fusion proteins, the fusion peptide (FP). Here, we reveal that HTLV’s FP modulates T-cell activity in-vitro and in-vivo. This modulation is characterized by downregulation of the Th1-response, leading to an elevated Th2-response observed by transition in mRNA, cytokines and regulatory proteins. Our findings suggest that FP mediated immune evasion might be a trait shared between different viruses.