A role for SINE-encoded RNA in neuronal regeneration?Date:
Lecture / Seminar
Location: Nella and Leon Benoziyo Building for Biological Sciences
Lecturer: Dr. Indrek Koppel
Organizer: Department of Biomolecular Sciences
Details: Dept. of Biomolecular Sciences-WIS
Abstract: B2 small noncoding RNAs are transcribed from short interspersed nuclear elements ... Read more B2 small noncoding RNAs are transcribed from short interspersed nuclear elements (SINEs), which are high copy number transposable elements in the mouse genome. B2 RNAs are upregulated upon cellular stress and may repress mRNA synthesis or affect protein translation. Surprisingly, we observed global upregulation of polyadenylated B2 RNAs in sensory neuron ganglia following periperal nerve injury. Interestingly, similar induction was not seen in optic nerve injury, a model of central nervous system injury. In this talk, I will discuss our efforts to understand the possible involvement of B2 RNAs (and their corresponding human Alu RNA analogs) in neuronal regeneration.