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Synthetic Ex Utero Embryogenesis: from Naive Stem Cells to Complete Embryo Models

Date:
18
Wednesday
October
2023
Lecture / Seminar
Time: 10:00-11:00
Location: Arthur and Rochelle Belfer Building for Biomedical Research
Lecturer: Prof. Jacob (Yaqub) Hanna
Contact: naomi.moses@weizmann.ac.il
Details: Developmental Club Series 2023-2024 Host: Dr. Meital Oren

Immunology and Regenerative Biology Colloquium

Date:
18
Wednesday
October
2023
Lecture / Seminar
Time: 11:00
Title: Multi-Potent Lung Stem Cells for Lung Regeneration
Location: Max and Lillian Candiotty Building
Lecturer: Prof. Yair Reisner
Organizer: Department of Immunology and Regenerative Biology
Contact: ronen.alon@weizmann.ac.il

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    Special Guest Seminar by Dr. Konstantin Feinberg

    Date:
    17
    Monday
    July
    2023
    Lecture / Seminar
    Time: 13:00-14:00
    Title: Schwann cells are key regulator of corneal epithelial renewal
    Location: Arthur and Rochelle Belfer Building for Biomedical Research
    Lecturer: Dr. Konstantin Feinberg
    Organizer: Department of Molecular Neuroscience
    Contact: ronitrosenberg@weizmann.ac.il
    Abstract: Purpose: Corneal sensory nerves protect the cornea from injury. They are also th ... Read more Purpose: Corneal sensory nerves protect the cornea from injury. They are also thought to stimulate limbal stem cells (LSCs) to produce transparent epithelial cells constantly, enabling vision. In other organs, Schwann cells (SCs) associated with tissue-innervating axon terminals mediate tissue regeneration. This study defines the critical role of the corneal axon-ensheathing SCs in homeostatic and regenerative corneal epithelial cell renewal. Methods: SC localization in the cornea was determined by in situ hybridization and immunohistochemistry with SC markers. In vivo SC visualization and/or ablation was performed in mice with inducible corneal SC-specific expression of TdTomato and/or Diphtheria toxin, respectively. The relative locations of SCs and LSCs was observed with immunohistochemical analysis of harvested genetically SC-pre-labeled mouse corneas with LSC-specific antibodies. The correlation between cornea-innervating axons and the appearance of SCs was ascertained using corneal denervation in rats. To determine the limbal niche cellular composition and gene expression changes associated with innervation-dependent epithelial renewal, single cell RNA sequencing (scRNA-Seq) of dissociated healthy, de-epithelized and enervated cornea limbi was performed. Results: We observed limbal enrichment of corneal axon-associated myelinating and non-myelinating SCs. Induced local genetic ablation of SCs, while leaving corneal sensory innervation intact, markedly inhibited corneal epithelial renewal. scRNA-seq analysis (i) highlighted the transcriptional heterogeneity of cells populating the limbal niche and (ii) identified transcriptional changes associated with corneal innervation and during wound healing that model potential regulatory paracrine interactions between SCs and LSCs. Conclusions: Limbal SCs are required for innervation-dependent corneal epithelial renewal.
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    Factors determining the early steps in the disease initiation of myeloproliferative neoplasms by the JAK2-mutated hematopoietic stem cell

    Date:
    17
    Wednesday
    May
    2023
    Lecture / Seminar
    Time: 10:00-11:00
    Location: Ullmann Building of Life Sciences
    Lecturer: Prof. Dr. Radek C. Skoda
    Organizer: Department of Molecular Cell Biology
    Contact: yael.lepek@weizmann.ac.il
    Details: Ullmann 101

    Human hematopoietic stem cells as sensors of inflammatory memory

    Date:
    10
    Wednesday
    May
    2023
    Lecture / Seminar
    Time: 11:00-12:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Stephanie Z. Xie
    Organizer: Department of Immunology and Regenerative Biology
    Contact: michal.av@weizmann.ac.il

    New approaches to early embryogenesis & epigenetics

    Date:
    13
    Monday
    February
    2023
    -
    15
    Wednesday
    February
    2023
    Conference
    Time: 08:00
    Location: The David Lopatie Conference Centre
    Organizer: The Aharon Katzir-Katchalsky Center,The Helen and Martin Kimmel Institute for Stem Cell Research
    Contact: yonatan.stelzer@weizmann.ac.il
    New approaches to early embryogenesis & epigenetics Conference website

    From Stem Cells to Synthetic Embryos

    Date:
    29
    Thursday
    December
    2022
    Lecture / Seminar
    Time: 13:00-14:00
    Location: Gerhard M.J. Schmidt Lecture Hall
    Lecturer: Dr. Noa Novershtern
    Contact: ayelet.vilan@weizmann.ac.il
    Abstract: Gastrulation, the early stage of embryonic development in which the organs are s ... Read more Gastrulation, the early stage of embryonic development in which the organs are starting to form, is an elusive stage, which is hard to investigate because its access in mammals is limited. In this talk I will describe how our lab was able to grow mouse embryos outside the uterus, and how our work on stem cells has ultimately enabled us to grow synthetic embryos, generated from stem cells without egg and sperm, thus allowing us a window to mammalian gastrulation.
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    Assembly or disassembly this is the question…

    Date:
    21
    Monday
    November
    2022
    Colloquium
    Time: 11:00-12:15
    Title: Annual Pearlman Lecture
    Location: Gerhard M.J. Schmidt Lecture Hall
    Lecturer: Prof. Luisa De Cola
    Organizer: Faculty of Chemistry
    Contact: sarah.amzallag@weizmann.ac.il
    Abstract: Molecules that can undergo self-assembly are of great interest for the developme ... Read more Molecules that can undergo self-assembly are of great interest for the development of new materials, sensors, biolabels…. In some cases the assembly can lead to an enhancement of the emission, a change in the luminescence energy and even to unexpected biological phenomena. The talk will illustrate some of the recent results on the self-assembly of platinum complexes and their evolution in solution[1]. Some water soluble compounds where studied to follow the self-assembly even in vivo and the resulting reactivity/toxicity of such species. We employed transparent polyps, Hydra vulgaris and an extraordinary phenomenon was detected with one of the complex that showed a clear effect on pluripotent stem cell proliferation, especially at low doses. The stabilization of transient species, formed in the assembly process can be achieved using cage type structures can lead to their stabilization or even existence in solution, in a condition out of equilibrium. We recently demonstrated[2] that it is possible to entrap intermediate states of luminescent assemblies and prevent their thermodynamic evolution towards the equilibrium state. Such cages are also the carriers for important drugs do to their destruction inside cells. Their biodistribution is quite unique and they are able to escape macrophages uptake.[3] References [1] A. Aliprandi, M. Mauro, L. De Cola Nature Chem., 2016, 8, 10-15 [2] P. Picchetti, G. Moreno-Alcántar, L. Talamini, A. Mourgout, A. Aliprandi, L. De Cola J. Am. Chem. Soc. 2021, 143, 7681-7687. [3] P. Picchetti et al. ACS Nano 2021, 15, 9701–9716
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    Assembly or disassembly this is the question… Colloquium website

    Immunology and Regenerative Biology Colloquium

    Date:
    15
    Thursday
    September
    2022
    Lecture / Seminar
    Time: 11:00-12:00
    Title: Stem Cells: Coping with Stress
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Prof. Elaine Fuchs
    Organizer: Department of Immunology and Regenerative Biology
    Contact: lili.kasumov@weizmann.ac.il
    Abstract: Using mammalian skin as a model, Prof. Elaine Fuchs studies the remarkable prope ... Read more Using mammalian skin as a model, Prof. Elaine Fuchs studies the remarkable properties of tissue stem cells to replenish dying cells and repair wounds, and how the cells know which tasks to perform and when. She explores how stem cells sense and communicate with other cells in their environment. Aiming at advancing therapeutics, she dissects how communication networks malfunction in inflammation, aging, and cancers.
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    Single-molecule and single-cell epigenetics: Decoding the epigenome for cancer research and diagnostics

    Date:
    28
    Thursday
    July
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Efrat Shema
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Promiscuous Translesion DNA Synthesis in Embryonic Stem Cells

    Date:
    14
    Tuesday
    June
    2022
    Lecture / Seminar
    Time: 10:30-11:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Ido Dromi
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il

    BRD4 in Transcription Programming and Cancer Therapy

    Date:
    26
    Thursday
    May
    2022
    Lecture / Seminar
    Time: 10:30-11:30
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Prof. Cheng-Ming Chiang
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Bromodomain-containing protein 4 (BRD4) is an epigenetic regulator and transcrip ... Read more Bromodomain-containing protein 4 (BRD4) is an epigenetic regulator and transcription cofactor whose phosphorylation by casein kinase II (CK2) and dephosphorylation by protein phosphatase 2A (PP2A) modulates its function in gene-specific targeting and recruitment of transcriptional regulators and chromatin modifiers. BRD4 has emerged as an important cancer therapeutic target due to widely available small compound inhibitors, such as JQ1 and I-BET, targeting the bromodomain and extra-terminal (BET) family members. Besides transcriptional regulation, BRD4 also plays crucial roles in regulating diverse cellular processes, including cell cycle progression, DNA damage response, chromatin structure maintenance, stem cell reprogramming, cell lineage differentiation, and viral latency and reactivation. While BET inhibitors and degraders show promising anticancer effects, issues related to drug resistance upon prolonged treatment remain a challenge in BET-targeted therapeutics development. Recently, we identified specific small compound inhibitors targeting phosphorylation-dependent BRD4 interaction with distinct transcription/replication components and DNA damage response (DDR) factors, including p53, c-Myc, AP-1, and cancer-associated human papillomavirus E2 proteins. Some of these compounds effectively block cancer cell growth and migration and specifically inhibit p53 interaction with BRD4. These new types of protein-protein interaction (PPI) inhibitors highlight molecular action distinct from the widely used BET bromodomain inhibitors.
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    Killing Cancer Stem Cells

    Date:
    28
    Thursday
    April
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Jeremy Rich, MD, MHS, MBA
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Killing Cancer Stem Cells

    Date:
    28
    Thursday
    April
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Prof. Jeremy N. Rich, MD, MHS, MBA
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Stem Cells, Regeneration and Aging Seminar

    Date:
    15
    Tuesday
    March
    2022
    Lecture / Seminar
    Time: 09:00-10:30
    Title: From single cells to tissues' dynamics in development and ageing
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Amos Tanay
    Organizer: Life Sciences
    Contact: karina.yaniv@weizmann.ac.il

    Skin stem cells in tissue regeneration and tumor formation

    Date:
    03
    Thursday
    February
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Yaron Fuchs
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    A Hair-Raising Tale: Nerve – Stem Cell Interactions

    Date:
    10
    Monday
    January
    2022
    Lecture / Seminar
    Time: 10:00-11:30
    Location: Wolfson Building for Biological Research
    Lecturer: Dr. Yulia Shwartz
    Organizer: Department of Molecular Cell Biology
    Contact: michal.ovadia@weizmann.ac.il
    Details: Zoom link: https://weizmann.zoom.us/j/97362645749?pwd=a1MxT0dCRkpKeC9pUE1JeDFPb ... Read more Zoom link: https://weizmann.zoom.us/j/97362645749?pwd=a1MxT0dCRkpKeC9pUE1JeDFPbDFPUT09 Meeting ID: 973 6264 5749 Password: 805785
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    Gallery: A Hair-Raising Tale: Nerve – Stem Cell Interactions Gallery
    A Hair-Raising Tale: Nerve – Stem Cell Interactions Lecture / Seminar website

    Molecular Genetics Departmental Seminar

    Date:
    11
    Sunday
    April
    2021
    Lecture / Seminar
    Time: 13:00-13:30
    Title: Identifying an RNA binding protein with suggested functions in translation during embryonic stem cell differentiation
    Location: https://weizmann.zoom.us/j/98861386247?pwd=YXR2aEFxaU9QYUo1NEtJbFgxTTgzUT09
    Lecturer: Nadav Goldberg
    Organizer: Department of Molecular Genetics
    Contact: sandra.britton@weizmann.ac.il

    “Engineering personalized tissue implants: From 3D printing to bionic organs”

    Date:
    11
    Sunday
    April
    2021
    Lecture / Seminar
    Time: 11:00-12:00
    Lecturer: Prof. Tal Dvir
    Organizer: Department of Molecular Chemistry and Materials Science
    Contact: ana.naamat@weizmann.ac.il
    Abstract: Zoom LInk: https://weizmann.zoom.us/j/95962123886?pwd=ZWV6WkwxKzlNU00zRU1ER3J ... Read more Zoom LInk: https://weizmann.zoom.us/j/95962123886?pwd=ZWV6WkwxKzlNU00zRU1ER3JIWkg4Zz09 In this talk I will describe cutting-edge bio and nanotechnologies for engineering functional tissues and organs, focusing on the design of new biomaterials mimicking the natural microenvironment, or releasing biofactors to promote stem cell recruitment and tissue protection. In addition, I will discuss the development of patient-specific materials and 3D-printing of personalized vascularized tissues and organs. Finally, I will show a new direction in tissue engineering, where, micro and nanoelectronics are integrated within engineered tissues to form cyborg tissues and bionic organs.
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    Seminar for MSc thesis defense - Nadav Goldberg

    Date:
    22
    Monday
    March
    2021
    Lecture / Seminar
    Time: 10:00-11:00
    Title: “PRRC2B – A novel RNA binding protein with potential functions in translation and embryonic stem cell differentiation”
    Location: Zoom: https://weizmann.zoom.us/j/93455419518?pwd=SW9ESG9lODNrWmZOd1Q5REg4OVBDUT09 Meeting ID: 934 5541 9518 Password: 341839
    Lecturer: Nadav Goldberg
    Organizer: Department of Molecular Genetics
    Contact: Evi.ben-ami@weizmann.ac.il
    Details: Zoom: https://weizmann.zoom.us/j/93455419518?pwd=SW9ESG9lODNrWmZOd1Q5REg4OVBDUT ... Read more Zoom: https://weizmann.zoom.us/j/93455419518?pwd=SW9ESG9lODNrWmZOd1Q5REg4OVBDUT09 Meeting ID: 934 5541 9518 Password: 341839
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    Special Guest Seminar

    Date:
    03
    Sunday
    January
    2021
    Lecture / Seminar
    Time: 15:00-16:30
    Title: "Socializing with the Neighbors: Stem Cells Reshape Their Environment to Coordinate Tissue Regeneration."
    Lecturer: Dr. Shiri Gur-Cohen
    Organizer: Life Sciences
    Contact: lili.kasumov@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/99093074201?pwd=N2hVRjQvRk10cEFGS2R3SkFTWFgwQT09 Mee ... Read more https://weizmann.zoom.us/j/99093074201?pwd=N2hVRjQvRk10cEFGS2R3SkFTWFgwQT09 Meeting ID: 990 9307 4201 Password: 319779
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