Upcoming

All upcoming events

Harnessing Mistakes to Expose Cancer’s Vulnerability

Date:
20
Thursday
March
2025
Lecture / Seminar
Time: 12:30-14:00
Title: Spotlight on Science lecture sponsored by the Staff Scientists Council
Location: Gerhard M.J. Schmidt Lecture Hall
Lecturer: Ilana Eyal
Contact: mark.a.iron@weizmann.ac.il
Abstract: Over the past few decades, immunotherapy has revolutionized cancer treatment wit ... Read more Over the past few decades, immunotherapy has revolutionized cancer treatment with great success in treating cancer patients and preventing tumor recurrence after surgery. Harnessing the immune system to fight cancer largely relies on the ability of T lymphocytes to distinguish between “self” and “non-self” to specifically identify and eliminate malignant cells. This is achieved through the recognition of neoantigens, tumor-specific proteins resulting from genetic mutations.The Samuels’ lab is exploring the immune-tumor interactions, with specific focus on the mechanisms underlying cancer-cell recognition, and developing novel strategies to increase antitumor immune responses.In this talk, I will present results from our recent studies investigating the link between mRNA mistranslation in cancer cells and immunological tumor control.
Close abstract

Spatial transcriptomics of pancreatic cancer development and immune cells targeting to restrict tumor growth

Date:
20
Thursday
March
2025
Lecture / Seminar
Time: 14:00-15:00
Location: Max and Lillian Candiotty Building
Lecturer: Dr. Oren Parnas
Organizer: Dwek Institute for Cancer Therapy Research

Regulation of immune cell function in tumor microenvironment of triple-negative breast cancer

Date:
27
Thursday
March
2025
Lecture / Seminar
Time: 14:00-15:00
Location: Max and Lillian Candiotty Building
Lecturer: Prof. Idit Shachar
Organizer: Dwek Institute for Cancer Therapy Research

Immunology and Regenerative Biology Colloquium

Date:
07
Monday
April
2025
Colloquium
Time: 11:00-12:00
Location: Max and Lillian Candiotty Building
Lecturer: Prof. Vijay Kumar Kuchroo
Organizer: Department of Immunology and Regenerative Biology
Contact: moshe.biton@weizmann.ac.il

Immunology and Regenerative Biology Colloquium

Date:
09
Wednesday
April
2025
Colloquium
Time: 11:00-12:00
Title: Extremotolerance - Life at the Edge
Location: Max and Lillian Candiotty Building
Lecturer: Prof. Alwin Köhler
Organizer: Department of Immunology and Regenerative Biology
Contact: ami.navon@weizmann.ac.il

Immunology and Regenerative Biology Colloquium

Date:
14
Wednesday
May
2025
Colloquium
Time: 11:00-12:00
Location: Max and Lillian Candiotty Building
Lecturer: Prof. Matthias Gunzer
Organizer: Department of Immunology and Regenerative Biology
Contact: ronen.alon@weizmann.ac.il

Immunology and Regenerative Biology Colloquium

Date:
16
Thursday
October
2025
Colloquium
Time: 11:00-12:00
Location: Max and Lillian Candiotty Building
Lecturer: Prof. Kari Alitalo
Organizer: Department of Immunology and Regenerative Biology
Contact: karina.yaniv@weizmann.ac.il

    Past

    All years202520242023

    All Events

    Immunology and Regenerative Biology Colloquium

    Date:
    05
    Wednesday
    March
    2025
    Colloquium
    Time: 11:00-12:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ralph Adams
    Organizer: Department of Immunology and Regenerative Biology
    Contact: karina.yaniv@weizmann.ac.il

    Pathogen-phage Cooperation During Mammalian Infection

    Date:
    25
    Tuesday
    February
    2025
    Lecture / Seminar
    Time: 12:30-13:30
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Anat A. Herskovits
    Organizer: Department of Immunology and Regenerative Biology
    Contact: sabina.rose@weizmann.ac.il

    Immunology and Regenerative Biology Colloquium

    Date:
    12
    Wednesday
    February
    2025
    Colloquium
    Time: 11:00-12:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. David Artis
    Organizer: Department of Immunology and Regenerative Biology
    Contact: moshe.biton@weizmann.ac.il

    Leveraging single cell technologies to engineer the immune system

    Date:
    30
    Thursday
    January
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Candiotty, Auditorium
    Lecturer: Prof. Ido Amit
    Organizer: Dwek Institute for Cancer Therapy Research

    Special Guest Seminar

    Date:
    29
    Wednesday
    January
    2025
    Lecture / Seminar
    Time: 11:00-12:00
    Title: Mapping Antibody-Mediated Mechanisms of Protection Against Shigella
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Biana Bernshtein
    Organizer: Department of Immunology and Regenerative Biology
    Contact: ronen.alon@weizmann.ac.il

    Anterior-Posterior Insula Circuit Mediates Retrieval of a Conditioned Immune Response in Mice

    Date:
    24
    Tuesday
    December
    2024
    Lecture / Seminar
    Time: 12:30-13:30
    Location: Gerhard M.J. Schmidt Lecture Hall
    Lecturer: Prof. Kobi Rosenblum
    Organizer: Department of Brain Sciences
    Contact: naomi.moses@weizmann.ac.il
    Abstract: The brain can form associations between sensory information of inner and/or oute ... Read more The brain can form associations between sensory information of inner and/or outer world (e.g. Pavlovian conditioning) but also between sensory information and the immune system. The phenomenon which was described in the last century is termed conditioned immune response (CIR) but very little is known about neuronal mechanisms subserving it.  The conditioned stimulus can be a given taste and the unconditioned stimulus is an agent that induces or reduces a specific immune response.  Over the last years, we and others revealed molecular and cellular mechanisms underlying taste valance representation in the anterior insular cortex (aIC). Recently, a circuit in the posterior insular cortex (pIC) encoding the internal representation of a given immune response was identified. Together, it allowed us to hypothesize and prove that the internal reciprocal connections between the anterior and posterior insula encode CIR.  One can look at CIR as a noon declarative form of Nocebo effect and thus we demonstrate for the first time a detailed circuit mechanism for Placebo/Nocebo effect in the cortex.
    Close abstract

    Reprogramming the Immune System: A New Avenue in Cancer Treatment

    Date:
    19
    Thursday
    December
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Mira Barda-Saad
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: michal.av@weizmann.ac.il
    Details: For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd= ... Read more For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09 Meeting ID: 506 540 2023 Password: 223081
    Close details

    Global virus outbreaks: Interferons as 1st responders

    Date:
    17
    Tuesday
    December
    2024
    Lecture / Seminar
    Time: 09:30-10:30
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Prof. Eleanor N. Fish
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Viral infections pose a major threat to human health. Vaccines protect from spec ... Read more Viral infections pose a major threat to human health. Vaccines protect from specificinfections, yet newly emerging or pandemic viral strains that exhibit genetic drift or reassortmentof genes preclude immediate responses using a vaccine strategy. Moreover, for SARS CoV-2,although current vaccines reduce severity of disease, they do not protect from re-infection,resulting in persistent community transmission and outbreaks. The emergence of drug resistancealso mitigates against pathogen-specific antiviral drugs. A complementary strategy focusing onthe host not the pathogen is the basis for development of broad-spectrum antivirals.Our immediate response to any and all virus infections is the immediate production of interferon(IFN). Data reveal that the robustness of an IFN response to respiratory infections, determinesthe outcome – an aggressive or mild infection. We provide evidence that an IFN response to viralinfection, and/or IFN treatment, induces an activated phenotype in target cells that results in anantiviral state and an optimized innate immune response, regardless of the virus. We extendedthese findings to examine the therapeutic potential of IFN treatment in hospitalized individualsinfected with SARS and showed that IFN treatment accelerated viral clearance and reduced lungabnormalities. Similarly, using human lung explants, IFN treatment cleared infection againstH5N1 avian and pandemic H1N1 influenza strains. During the Ebola virus outbreak in WestAfrica, we conducted a clinical study in Guinea and provided evidence of increased survivalassociated with IFN treatment. At the start of the COVID-19 pandemic we undertook a clinicalstudy in Wuhan, China, providing evidence that early treatment with an inhaled IFN acceleratedviral clearance, reduced inflammation and also reduced lung abnormalities. Given that limitingtransmission is the solution to shutting down any outbreak, we next conducted a clinical trial todetermine whether IFN treatment of SARS CoV-2 exposed, but uninfected individuals, wouldprotect from infection. We provide evidence that prophylactic treatment with IFN limitshousehold transmission, being most effective when the infected case in the household has a highviral burden.
    Close abstract

    The Clore Center for Biological Physics

    Date:
    15
    Sunday
    December
    2024
    Lecture / Seminar
    Time: 12:45-14:30
    Title: Rationally designed functionalization of single-walled carbon nanotubes for real-time monitoring of active processes
    Location: Nella and Leon Benoziyo Physics Library
    Lecturer: Prof. Gili Bisker
    Organizer: Clore Center for Biological Physics
    Contact: debbie.hen@weizmann.ac.il
    Abstract: Semiconducting single-walled carbon nanotubes (SWCNTs) fluoresce in the near-inf ... Read more Semiconducting single-walled carbon nanotubes (SWCNTs) fluoresce in the near-infrared (NIR) range, which overlaps with the transparency window of biological samples, and they do not photobleach or blink. These properties make SWCNTs uniquely suited for long-term imaging and sensing applications. Using tailored surface functionalization, SWCNTs can act as dynamic optical nanosensors, transducing biochemical changes in their environment into modulations in fluorescence intensity. Owing to their intrinsic physicochemical and optical properties, SWCNTs can provide real-time, spatiotemporal information on active processes across scales, from molecular interactions to whole organism dynamics.Here, I will discuss different strategies for utilizing rationally designed functionalized SWCNTs to probe active biological processes. These include monitoring enzymatic activity, tracking supramolecular self-assembly and disassembly, and mapping in vivo processes. These findings showcase the potential of near-infrared fluorescent SWCNTs to provide insights into dynamic biological systems.LINK FOR STUDENTS INTERESTED MEETING PROF. GILI BISKER 14:30-15:15  Link FOR THE LATEST UPDATES AND CONTENT ON SOFT MATTER AND BIOLOGICAL PHYSICS AT THE WEIZMANN, VISIT OUR WEBSITE: https://www.biosoftweizmann.com/
    Close abstract

    The Clore Center for Biological Physics

    Date:
    15
    Sunday
    December
    2024
    Lecture / Seminar
    Time: 00:00-01:00
    Title: Rationally designed functionalization of single-walled carbon nanotubes for real-time monitoring of active processes
    Location: Nella and Leon Benoziyo Physics Library
    Lecturer: Prof. Gili Bisker
    Organizer: Clore Center for Biological Physics
    Contact: debbie.hen@weizmann.ac.il
    Abstract: Semiconducting single-walled carbon nanotubes (SWCNTs) fluoresce in the near-inf ... Read more Semiconducting single-walled carbon nanotubes (SWCNTs) fluoresce in the near-infrared (NIR) range, which overlaps with the transparency window of biological samples, and they do not photobleach or blink. These properties make SWCNTs uniquely suited for long-term imaging and sensing applications. Using tailored surface functionalization, SWCNTs can act as dynamic optical nanosensors, transducing biochemical changes in their environment into modulations in fluorescence intensity. Owing to their intrinsic physicochemical and optical properties, SWCNTs can provide real-time, spatiotemporal information on active processes across scales, from molecular interactions to whole organism dynamics.Here, I will discuss different strategies for utilizing rationally designed functionalized SWCNTs to probe active biological processes. These include monitoring enzymatic activity, tracking supramolecular self-assembly and disassembly, and mapping in vivo processes. These findings showcase the potential of near-infrared fluorescent SWCNTs to provide insights into dynamic biological systems.LINK FOR STUDENTS INTERESTED MEETING PROF. GILI BISKER 14:30-15:15  Link FOR THE LATEST UPDATES AND CONTENT ON SOFT MATTER AND BIOLOGICAL PHYSICS AT THE WEIZMANN, VISIT OUR WEBSITE: https://www.biosoftweizmann.com/
    Close abstract

    Location matters - a spatial view of cellular interactions

    Date:
    24
    Sunday
    November
    2024
    Lecture / Seminar
    Time: 09:00-10:00
    Title: The Department of Molecular Cell Biology and the Department of Immunology & Regenerative Biology Guest Seminar
    Location: Wolfson Building for Biological Research
    Lecturer: Dr. Michal Polonsky
    Organizer: Department of Molecular Cell Biology
    Contact: michal.ovadia@weizmann.ac.il
    Details: Bio: Throughout my scientific training, I have been fascinated by how inter-ce ... Read more Bio: Throughout my scientific training, I have been fascinated by how inter-cellular interactions regulate cell fate decisions. During my graduate work with Prof. Nir Friedman at the Weizmann I studied the effect of intercellular interactions on T cell memory differentiation. I then joined the lab of Prof Long Cai at Caltech, a world leader in developing in-situ spatial biology technologies. At the Cai lab I am applying spatial transcriptomics to study cellular interactions and their consequences on various pathologies such as acute kidney injury and in human glioma.
    Close details

    Stromal and Immune Plasticity Shape The Metastatic Microenvironment

    Date:
    07
    Thursday
    November
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Neta Erez
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    ABC CHATS: Noam Solomon-Immunai

    Date:
    10
    Wednesday
    July
    2024
    Lecture / Seminar
    Time: 14:00-15:30
    Title: My way from Mathematical research to decoding the immune system with AI
    Location: George and Esther Sagan Students' Residence Hall
    Lecturer: Noam Solomon
    Contact: reut.magor@weizmann.ac.il
    Details: In this talk Noam Solomon will share Immunai's story of mapping the immune syste ... Read more In this talk Noam Solomon will share Immunai's story of mapping the immune system with engineering and artificial intelligence and intertwine it into his own personal journey and what led him to transition from doing academic research in mathematics and computer science into the unknowns of starting his own company in the bio space, an adventure that started 6 years ago. Join our ABC CHATS where CEOs share their ABC’s on scientific leadership, breakthroughs and failures throughout their personal stories
    Close details

    Immunological aspects of immune checkpoint blockade

    Date:
    27
    Thursday
    June
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Yuval Shaked
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZw ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    AI (R)Evolution in (Quantum) Chemistry and Physics

    Date:
    10
    Monday
    June
    2024
    Colloquium
    Time: 11:00-12:15
    Title: Annual Pearlman Lecture
    Location: Gerhard M.J. Schmidt Lecture Hall
    Lecturer: Prof. Alexandre Tkatchenko
    Organizer: Department of Molecular Chemistry and Materials Science
    Contact: sarah.amzallag@weizmann.ac.il
    Abstract: Learning from data has led to paradigm shifts in a multitude of disciplines, inc ... Read more Learning from data has led to paradigm shifts in a multitude of disciplines, including web, text and image search and generation, speech recognition, as well as bioinformatics. Can machine learning enable similar breakthroughs in understanding (quantum) molecules and materials? Aiming towards a unified machine learning (ML) model of molecular interactions in chemical space, I will discuss the potential and challenges for using ML techniques in chemistry and physics. ML methods can not only accurately estimate molecular properties of large datasets, but they can also lead to new insights into chemical similarity, aromaticity, reactivity, and molecular dynamics. For example, the combination of reliable molecular data with ML methods has enabled a fully quantitative simulation of protein dynamics in water (https://arxiv.org/abs/2205.08306). While the potential of machine learning for revealing insights into molecules and materials is high, I will conclude my talk by discussing the many remaining challenges.
    Close abstract
    AI (R)Evolution in (Quantum) Chemistry and Physics Colloquium website

    RNA transmission between honeybees and their microbiome

    Date:
    02
    Thursday
    May
    2024
    Lecture / Seminar
    Time: 15:00-16:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Dr. Eyal Maori
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Transmissible RNA has emerged as a means of communication between organisms, bot ... Read more Transmissible RNA has emerged as a means of communication between organisms, both within and across different kingdoms of life. Donor organisms transmit long base-paired RNA, tRNA-fragments, and other small RNAs to elicit RNAi responses in recipient individuals, affecting their gene expression and phenotypes. Honeybees offer a unique opportunity to study RNA transmission since they possess a transmissible RNA pathway through which they share RNAs between individuals and across generations via the secretion and ingestion of worker- and royal jelly. We hypothesised that members of the gut microbiome exploit the same pathway and transmit RNA to their honeybee host. We show that RNA originating from a gut-restricted bacterium, Snodgrassella alvi (S. alvi), can be detected in worker- and royal jellies. Endogenous S. alvi RNAs are present also in systemic larval tissues in the absence of bacterial genomic DNA, indicating jelly-mediated microbiome RNA uptake and systemic spread within recipient larvae. Characterisation of transmissible S. alvi RNA reveals enrichment of specific rRNA and tRNA fragments in systemic larval tissues. The transmitted RNA fragments could potentially be involved in RNAi and have the capacity to target honeybee pathogens, such as Nosema and viruses. An expanded transmissible RNA pathway and its potential cooperative roles in honeybee- microbiome interactions will be discussed.
    Close abstract

    Melanosomes as cancer immune modulators

    Date:
    11
    Thursday
    April
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Carmit Levy
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd= ... Read more For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09 Meeting ID: 506 540 2023 Password: 223081
    Close details

    Immunology and Regenerative Biology Colloquium

    Date:
    28
    Wednesday
    February
    2024
    Lecture / Seminar
    Time: 11:00-12:00
    Title: Multi-Potent Lung Stem Cells for Lung Regeneration
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Yair Reisner
    Organizer: Department of Immunology and Regenerative Biology
    Contact: ronen.alon@weizmann.ac.il

    German Israeli Immunology Workshop

    Date:
    14
    Wednesday
    February
    2024
    -
    15
    Thursday
    February
    2024
    Conference
    Time: 08:00
    Location: The David Lopatie Conference Centre
    Contact: s.jung@weizmann.ac.il
    German Israeli Immunology Workshop Conference website

    The Language of Bacterial Pathogens, Commensals, and Biomedical Potentials

    Date:
    08
    Thursday
    February
    2024
    Lecture / Seminar
    Time: 15:00-16:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Dr. Neta Sal-Man
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Reported cases of diarrheal samples exhibiting co-infections or multiple infecti ... Read more Reported cases of diarrheal samples exhibiting co-infections or multiple infections with two or more infectious agents are on the rise, likely due to advances in bacterial diagnostic techniques. Our work aims to decode the communication between bacterial pathogens within the digestive system and investigates whether they compete or cooperate. Additionally, we examine how commensal strains of the microbiome intercept this communication through specific metabolites
    Close abstract

    Next-generation antibody-based cancer immunotherapies

    Date:
    11
    Thursday
    January
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Rony Dahan
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZw ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    Immunoception: Brain Representation and Control of Immunity

    Date:
    09
    Tuesday
    January
    2024
    Lecture / Seminar
    Time: 13:00
    Location: Wolfson Building for Biological Research
    Lecturer: Prof. Asya Rolls
    Organizer: Department of Brain Sciences
    Contact: naomi.moses@weizmann.ac.il
    Details: Host. Dr. Yoav Livneh yoav.livneh@weizmann.ac.il For accessibility issues: na ... Read more Host. Dr. Yoav Livneh yoav.livneh@weizmann.ac.il For accessibility issues: naomi.moses@weizmann.ac.il
    Close details
    Abstract: To function as an integrated entity, the organism must synchronize between behav ... Read more To function as an integrated entity, the organism must synchronize between behavior and physiology. Our research focuses on probing this synchronization through the lens of the brain-immune system interface. The immune system, pivotal in preserving the organism's integrity, is also a sensitive barometer of its overall state. I will discuss the emerging understanding of how the brain represents the state of the immune system and the specific neural mechanisms that enable the brain to orchestrate immune responses.
    Close abstract

    Dissecting the role of peripheral immunity in Alzheimer’s Disease pathogenesis and disease course

    Date:
    23
    Thursday
    November
    2023
    Lecture / Seminar
    Time: 11:30-12:30
    Title: Student Seminar PhD Thesis Defense ZOOM
    Lecturer: Tommaso Croese PhD Defense
    Organizer: Department of Brain Sciences
    Contact: naomi.moses@weizmann.ac.il
    Details: Zoom Link: https://weizmann.zoom.us/j/5420322495?pwd=ZmhUR0kxWTB6aDh0bklBNFlzV1J ... Read more Zoom Link: https://weizmann.zoom.us/j/5420322495?pwd=ZmhUR0kxWTB6aDh0bklBNFlzV1JNdz09 Meeting ID: 542 032 2495 Password: 862769
    Close details
    Abstract: Recent research has increasingly focused on the intricate interactions between t ... Read more Recent research has increasingly focused on the intricate interactions between the brain and the immune system, a critical line of inquiry for understanding neurological disorders like Alzheimer's Disease (AD). AD, once defined primarily by amyloid-β and tau aggregations, is now being explored for its complex interplay with immune processes, offering a deeper understanding of its development. This study delves into the dynamic relationship between the brain and the immune system, utilizing human samples from individuals predisposed to AD and various preclinical models. Our findings reveal that both environmental and genetic risk factors for AD significantly influence immune phenotypes and functions, which in turn impact disease progression. Further, we discovered that disrupting brain-spleen communication alters myeloid cell fate and cognitive performance in 5xFAD mice. These insights demonstrate the profound and reciprocal influence between the brain and the immune system. They underscore the importance of these interactions in understanding not only AD but also a wider array of neurological conditions, suggesting that this interplay is crucial for comprehending the complexities of such diseases. Zoom Link: https://weizmann.zoom.us/j/5420322495?pwd=ZmhUR0kxWTB6aDh0bklBNFlzV1JNdz09 Meeting ID: 542 032 2495 Password: 862769
    Close abstract

    Dissecting the immune-controlled signaling networks driving breast cancer progression

    Date:
    28
    Thursday
    September
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Merav Cohen
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    Intra-host evolution of HIV env after broadly-neutralizing antibody infusion

    Date:
    15
    Tuesday
    August
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Gerhard M.J. Schmidt Lecture Hall
    Lecturer: Dr. Frida Belinky
    Organizer: Department of Chemical and Structural Biology
    Contact: nicole.dorfman@weizmann.ac.il

    PhD Thesis Defense by Amichay Afriat (Shalev Itzkovitz Lab)

    Date:
    10
    Monday
    July
    2023
    Lecture / Seminar
    Time: 12:00-14:00
    Title: Spatio-temporal analysis of host-pathogen interactions in zonatedmetabolic tissues
    Location: Ullmann Building of Life Sciences
    Lecturer: Amichay Afriat
    Organizer: Department of Molecular Cell Biology
    Contact: michal.ovadia@weizmann.ac.il

    Localized but not Systemic Type I Interferon Therapy Improves Immune Infiltration and PD-blockade in a Mouse Melanoma Model

    Date:
    27
    Tuesday
    June
    2023
    Lecture / Seminar
    Time: 10:00-11:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Dr. Daniel Harari
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Daniel Harari 1, Ron Rotkopf 2, Shlomit Reich-Zeliger 3, Mathumathi Krishnamohan ... Read more Daniel Harari 1, Ron Rotkopf 2, Shlomit Reich-Zeliger 3, Mathumathi Krishnamohan 1, Alona Dov 1, Vladislav Volchinski 1 and Gideon Schreiber 1 1. Dept. Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel 2. Bioinformatics Unit, The Weizmann Institute of Science 3. Dept. Immunology, The Weizmann Institute of Science Transcriptomic analysis of tumor biopsies from metastatic melanoma patients (SKCM-TCGA) demonstrates a profound survival advantage for approximately one-third of patients who exhibit the highest levels of intratumoral type I Interferon (IFN-I) signaling (Hazard Ratio 0.36; Pr: 4E-06), these which coincide with a sharp increase in transcripts indicating infiltration of CD4-T, CD8-T, B-cells and Macrophages to the tumors. Pathway analysis furthermore demonstrates that these patients exhibit T- and B-cell activation and a Th-1 response. To test if IFN-I signaling is central to and not simply correlating with these associated factors, we employed an adeno-associated virus (AAV) delivery system, locally expressing mouse IFNβ in B16F10 cells grafted into congenic C57BL/6 mice, this a known cold tumor model particularly hard to treat. Whereas anti-PDL1 monotherapy had no response in this model, combination therapy slowed, and in some cases cleared the mice of tumors. AAV-IFNβ monotherapy alone can slow but will not cure the mice. In sharp contrast to localized IFN delivery, systemic IFN therapy showed no beneficial effects in slowing tumor growth. To examine this more deeply, we injected the mice bilaterally with B16F10 tumors, where one tumor received AAV- IFNβ and the contralateral tumor received control. Both the injected and contralateral tumors nevertheless demonstrated a large reduction in tumor size, this effect lost when repeated using IFNAR2 knockout mice. Furthermore both the IFN-treated and contralateral tumors exhibited a large increase in CD3+CD4+ and CD3+CD4- lymphocytes. We submit that enforcing localized IFN-I signaling to a tumor in melanoma can drive immune cell infiltration, with the potential to elicit a systemic immune response, and possibly even cure, particularly when used in combination with immune checkpoint inhibitors.
    Close abstract

    Immunology and Regenerative Biology Colloquium

    Date:
    19
    Monday
    June
    2023
    Lecture / Seminar
    Time: 11:00-12:00
    Title: “Tackling Big Questions in TB: a View from South Africa”
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Valerie Mizrahi
    Organizer: Department of Immunology and Regenerative Biology
    Contact: roi.avraham@weizmann.ac.il

    Stromal and immune plasticity shape the metastatic microenvironment

    Date:
    18
    Thursday
    May
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Neta Erez
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    Immunology and Regenerative Biology Colloquium

    Date:
    14
    Sunday
    May
    2023
    Lecture / Seminar
    Time: 11:00-12:00
    Title: The behavior and influence of neutrophil granulocytes under physiological and pathological conditions
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Matthias Gunzer
    Organizer: Department of Immunology and Regenerative Biology
    Contact: ronen.alon@weizmann.ac.il

    Toward complete computational optimization of antibody

    Date:
    04
    Thursday
    May
    2023
    Lecture / Seminar
    Time: 09:00-10:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Ariel Tennenhouse, hosted by Dr. Ira Zaretsky
    Organizer: Department of Life Sciences Core Facilities
    Contact: ira.zaretsky@weizmann.ac.il

    Immunology and Regenerative Biology Colloquium

    Date:
    23
    Sunday
    April
    2023
    Lecture / Seminar
    Time: 11:00-12:00
    Title: "RNA-targeting opportunities in age-related disorders"
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Fabrizio d'Adda di Fagagna
    Organizer: Department of Immunology and Regenerative Biology
    Contact: igor.ulitsky@weizmann.ac.il

    Turning immune “cold” into immune “hot” tumors by reverting the tumor microenvironment into hostile to the cancer cells.

    Date:
    30
    Thursday
    March
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Avigdor Scherz
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    Fascinating World of Plant Volatiles: Beyond the Traditional View

    Date:
    26
    Sunday
    March
    2023
    Lecture / Seminar
    Time: 11:30-12:30
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Prof. Natalia Doudareva
    Organizer: Department of Plant and Environmental Sciences
    Contact: david.zeevi@weizmann.ac.il
    Abstract: Abstract: Plants synthesize an amazing diversity of volatile organic compounds ... Read more Abstract: Plants synthesize an amazing diversity of volatile organic compounds (VOCs) that facilitate interactions with their environment, ranging from attracting pollinators and seed dispersers to protecting themselves from pathogens, parasites, and herbivores. Plants are also targets of released compounds as a part of plant-plant communication, as well as plant-insect and plant-microbe interactions. They are constantly exposed to atmospheric VOCs and can differentiate and respond to specific cues. Therefore, VOC release out of the cell and perception of emitted volatiles are an essential part of information exchange. The presented results will cover different aspects of VOC biosynthesis and emission including the involvement of heterodimeric enzymes in VOC biosynthesis, the role of transporters, lipid transfer proteins and lipid droplets in VOC trafficking out o! f the cell, and the function of the cuticle as an integral member of the overall VOC biosynthetic network. This presentation will also discuss the latest knowledge about VOC perception: from an inter-organ aerial transport of VOCs via natural fumigation and hormone-like function for terpenoid compounds to a signaling pathway(s) involved.
    Close abstract

    Immunology and Regenerative Biology Colloquium

    Date:
    26
    Sunday
    March
    2023
    Lecture / Seminar
    Time: 11:00-12:00
    Location: Wolfson Building for Biological Research
    Lecturer: Prof. Francisco J. Quintana
    Organizer: Department of Immunology and Regenerative Biology
    Contact: s.jung@weizmann.ac.il

    Autotaxin in the tumor microenvironment: from discovery to metastasis and immune evasion

    Date:
    23
    Thursday
    March
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Wouter Moolenaar
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    Shigella flexneri vacuolar rupture : Near-native in cellulo structure-function analysis

    Date:
    12
    Sunday
    March
    2023
    Lecture / Seminar
    Time: 13:30-14:30
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Léa SWISTAK
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Shigella flexneri is a bacterial entero-invasive pathogen transmitted through th ... Read more Shigella flexneri is a bacterial entero-invasive pathogen transmitted through the fecal/oral route causing bacillary dysentery in humans. Shigella pathogenicity solely relies on a needle-like molecular syringe, the Type 3 Secretion System (T3SS) that injects more than 20 bacterial effectors to infect colonic epithelial cells. The T3SS is composed of a basal body that controls and initiates effector secretion and a needle complex that acts as a conduit for effector delivery. The needle is capped by a tip complex that regulates whether the needle is closed or whether it secretes. Sensing of host cells by the needle tip complex induces a conformational switch that remodels the tip and activates the T3SS to form a channel, the translocon pore at the distal end. Effectors are then actively secreted, promoting cell invasion and endocytosis of the bacteria in a tight vacuole derived from the host plasma membrane called Bacteria Containing Vacuole (BCV). Quickly after entry, the pathogen ruptures its BCV and establish a replicative cytosolic niche. Vacuolar rupture consists of a first step of BCV breakage followed by BCV remnants unpeeling. The team has identified bacterial effectors promoting efficient vacuole unpeeling but the direct role of the T3SS in membrane destabilization is not clear. I have overcome these limitations by investigating the T3SS/vacuole interactions at the onset of vacuolar rupture using a novel cryo-Correlative Light Electron Microscopy (CLEM) workflow applied in situ, during the host-pathogen crosstalk. Cryo-CLEM allows the combination of high-resolution information in 3D, accessed via cryo-Electron Tomography (cryo-ET) to functional information brought by light microscopy. This pipeline benefits from in-house custom-built genetically encoded reporter cell lines which are used to identify precise steps of the infection at high spatiotemporal resolution. Using this workflow, I collected cryo-ET data on Shigella-infected epithelial cells. I have been able to visualize the Shigella T3SS at molecular resolution providing unprecedented information. Particularly, I am looking at (i) the contact sites between T3SS and BCV membrane; (ii) T3SS morphologies depending on its activation state. Together this work will allow to precisely describe the interplay between host and bacteria processes.
    Close abstract

    Sensitizing P-selectin-expressing brain malignancies to immune checkpoint modulators

    Date:
    16
    Thursday
    February
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ronit Satchi-Fainaro, PhD
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    The power of ONE: Immunology in the age of single cell genomics

    Date:
    05
    Thursday
    January
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ido Amit
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details