Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

Date:

Tuesday

April

2021

Lecture / Seminar

Time: 10:00-11:00

Location: Nella and Leon Benoziyo Building for Biological Sciences

Lecturer: Oshrat Galibov-Levi

Organizer: Department of Biomolecular Sciences

Contact: levana.ayvazo@weizmann.ac.il

Details: Dept. of Biomolecular Sciences-WIS

Abstract: In the colon, long-term exposure to chronic inflammation drives colitis-associat ... Read more In the colon, long-term exposure to chronic inflammation drives colitis-associated colon cancer (CAC). However, molecular understanding of how this occurs is still lacking. Within the tumor, cancer cells are surrounded by a variety of non-malignant cells and by the extracellular matrix (ECM), which together compose the tumor microenvironment (TME), which is essential for tumor homeostasis and progression. While the cancer cells are highly mutated, the stromal cells are genomically stable. Master regulator heat shock factor 1 (HSF1) was shown to play an important part in the transcriptional reprogramming of the TME. By using proteomic and advanced methods of microscopy and image analysis we show that HSF1-dependent ECM remodeling plays a crucial role in mediating inflammation-driven colon cancer. /j/95881429481?pwd=VkxwUmg1Z2ErZmhpZDJqMTZwellGZz09

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