-
Subcellular particles for characterization of host-parasite interactions
-
Deconvoluting low yield from weak potency in direct-to-biology workflows with machine learning
-
Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor
-
Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies
-
Proteolytic Vesicles Derived from Salmonella enterica Serovar Typhimurium-Infected Macrophages: Enhancing MMP-9-Mediated Invasion and EV Accumulation
-
Structural basis of Gabija anti-phage defence and viral immune evasion
-
Functionally Diverse Peroxygenases by AlphaFold2, Design, and Signal Peptide Shuffling
-
The underlying mechanisms of arenaviral entry through matriglycan
-
Tuft cells and fibroblasts promote thymus regeneration through ILC2-mediated type 2 immune response
-
Lowering mutant huntingtin by small molecules relieves Huntington’s disease symptoms and progression
-
Integrated Metabolomics and Proteomics of Symptomatic and Early Presymptomatic States of Colitis
-
VWD domain stabilization by autocatalytic Asp-Pro cleavage
-
Phages overcome bacterial immunity via diverse anti-defence proteins
-
p53: A tale of complexity and context
-
Activation of Thoeris antiviral system via SIR2 effector filament assembly
-
A pathogenic variant in the uncharacterized RNF212B gene results in severe aneuploidy male infertility and repeated IVF failure
-
Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets
-
Cryo-EM structure of the RADAR supramolecular anti-phage defense complex
-
Compositional variances in cuticular lipids of wild and domesticated barley leaves and their impact on plant-environment interactions
-
A conserved family of immune effectors cleaves cellular ATP upon viral infection
-
Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins
-
The evolutionary success of regulated cell death in bacterial immunity
-
L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
-
Guidelines for the purification and characterization of extracellular vesicles of parasites
-
Enhanced transmissibility, infectivity, and immune resistance of the SARS-CoV-2 omicron XBB.1.5 variant
-
Redefining metalloproteases specificity through network proteolysis
-
Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification
-
Stable Mammalian Serum Albumins Designed for Bacterial Expression
-
Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases
-
High-throughput analysis of the transcriptional patterns of sexual genes in malaria
-
miR-4734 conditionally suppresses ER stress-associated proinflammatory responses
-
The defense island repertoire of the Escherichia coli pan-genome
-
Longitudinal in vivo imaging of perineuronal nets
-
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors
-
Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics
-
Resistance of Lung Cancer to EGFR-Specific Kinase Inhibitors: Activation of Bypass Pathways and Endogenous Mutators
-
Tree tobacco (Nicotiana glauca) cuticular wax composition is essential for leaf retention during drought, facilitating a speedy recovery following rewatering
-
Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C-H Oxyfunctionalization Reactions
-
A structural perspective on the evolution of viral/cellular macromolecular complexes within the arenaviridae family of viruses
-
Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant
-
Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation
-
Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition
-
Parallel evolution of cannabinoid biosynthesis
-
Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells
-
Selective translational control of cellular and viral mRNAs by RPS3 mRNA binding
-
Paradoxical activation of chronic lymphocytic leukemia cells by ruxolitinib in vitro and in vivo
-
Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform
-
CARD-like domains mediate anti-phage defense in bacterial gasdermin systems
-
Apoptotic cell death in disease—Current understanding of the NCCD 2023
-
Biogenesis of extracellular vesicles in protozoan parasites: The ESCRT complex in the trafficking fast lane?
-
Characterization of the evolutionary and virological aspects of mutations in the receptor binding motif of the SARS-CoV-2 spike protein
-
TAZ facilitates breast tumor growth by promoting an immune-suppressive tumor microenvironment
-
A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei
-
Turning high-throughput structural biology into predictive inhibitor design
-
Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis
-
Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques
-
Discovery of phage determinants that confer sensitivity to bacterial immune systems
-
The C-terminal tail of CSNAP attenuates the CSN complex
-
Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants
-
A BAHD-type acyltransferase concludes the biosynthetic pathway of non-bitter glycoalkaloids in ripe tomato fruit
-
Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry
-
Combinatorial assembly and design of enzymes
-
Trapping all ERBB ligands decreases pancreatic lesions in a murine model of pancreatic ductal adenocarcinoma
-
Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants
-
Designed active-site library reveals thousands of functional GFP variants
-
p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells
-
Amyloid Precursor Protein and Tau Peptides Linked Together Ameliorate Loss of Cognition in an Alzheimer’s Disease Animal Model
-
Bacteria deplete deoxynucleotides to defend against bacteriophage infection
-
Cap-independent translation and a precisely located RNA sequence enable SARS-CoV-2 to control host translation and escape anti-viral response
-
Diffraction contrast in cryo-scanning transmission electron tomography reveals the boundary of hemozoin crystals in situ
-
Sialylated N‐glycans mediate monocyte uptake of extracellular vesicles secreted from Plasmodium falciparum‐infected red blood cells
-
Tumor-reactive antibodies evolve from non-binding and autoreactive precursors
-
Diffusion of small molecule drugs is affected by surface interactions and crowder proteins
-
Perspectives: SARS-CoV-2 Spike Convergent Evolution as a Guide to Explore Adaptive Advantage
-
Highly Specific Monoclonal Antibody Targeting the Botulinum Neurotoxin Type E Exposed SNAP-25 Neoepitope
-
Stable and Functionally Diverse Versatile Peroxidases Designed Directly from Sequences
-
Stabilization of the SARS-CoV-2 receptor binding domain by protein core redesign and deep mutational scanning
-
Disulfide bond formation and redox regulation in the Golgi apparatus
-
Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors
-
Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis
-
Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson’s disease patients
-
The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA
-
Assessing and enhancing foldability in designed proteins
-
An expanded arsenal of immune systems that protect bacteria from phages
-
The SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant
-
Malaria parasites release vesicle subpopulations with signatures of different destinations
-
Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin
-
Designed High-Redox Potential Laccases Exhibit High Functional Diversity
-
Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike
-
Extracellular vesicle fusion visualized by cryo-electron microscopy
-
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
-
Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals
-
Bacterial gasdermins reveal an ancient mechanism of cell death
-
Polyclonal antibody-induced downregulation of HER1/EGFR and HER2 surpasses the effect of combinations of specific registered antibodies
-
Gelatin Stabilizes Nebulized Proteins in Pulmonary Drug Delivery against COVID-19
-
Structural basis for matriglycan synthesis by the LARGE1 dual glycosyltransferase
-
Identification and characterization of the key enzyme in the biosynthesis of the neurotoxin β-ODAP in grass pea
-
Intracellular peptides as drug prototypes
-
What Have We Learned from Design of Function in Large Proteins?
-
Kidney Failure Alters Parathyroid Pin1 Phosphorylation and Parathyroid Hormone mRNA-Binding Proteins, Leading to Secondary Hyperparathyroidism
-
Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia
-
Uncovering Pathways Highly Correlated to NUE through a Combined Metabolomics and Transcriptomics Approach in Eggplant
-
2-Oxoglutarate-Dependent Dioxygenases Drive Expansion of Steroidal Alkaloid Structural Diversity in the Genus Solanum
-
5’isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1
-
Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins
-
Genetically Engineered MRI-Trackable Extracellular Vesicles as SARS-CoV-2 Mimetics for Mapping ACE2 Binding In Vivo
-
SnapShot: Bacterial immunity
-
Structure and receptor recognition by the Lassa virus spike complex
-
Imaging of Extracellular Vesicles Derived from Plasmodium falciparum–Infected Red Blood Cells Using Atomic Force Microscopy
-
Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity
-
Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation
-
Anti-SARS-CoV-2 immunoadhesin remains effective against Omicron and other emerging variants of concern
-
Bacterial origins of human cell-autonomous innate immune mechanisms
-
Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression
-
Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients
-
Visual barcodes for clonal-multiplexing of live microscopy-based assays
-
Viruses inhibit TIR gcADPR signalling to overcome bacterial defence
-
Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds
-
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer
-
Blockade of the protease ADAM17 ameliorates experimental pancreatitis
-
Monitoring Distribution Dynamics of EV RNA Cargo Within Recipient Monocytes and Macrophages
-
Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis
-
Drugging p53 in cancer: one protein, many targets
-
Computationally designed hyperactive Cas9 enzymes
-
Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature
-
Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion
-
Structural Studies Reveal the Role of Helix 68 in the Elongation Step of Protein Biosynthesis
-
Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2a-phosphorylation
-
Germline genetic biomarkers to stratify patients for personalized radiation treatment
-
Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 Mice
-
Peptidomic profiling of cerebrospinal fluid from patients with intracranial saccular aneurysms
-
Transcriptomics reveal new insights into molecular regulation of nitrogen use efficiency in Solanum melongena
-
Site-Specific Labeling of Endogenous Proteins Using CoLDR Chemistry
-
TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment
-
Conformational switches and redox properties of the colon cancer‐associated human lectin ZG16
-
The rise of covalent proteolysis targeting chimeras
-
Intracellular protein‐drug interactions probed by direct mass spectrometry of cell lysates
-
The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3
-
Protein Engineering in the Design of Protein–Protein Interactions: SARS-CoV-2 Inhibitors as a Test Case
-
20S proteasomes secreted by the malaria parasite promote its growth
-
A white-knuckle ride of open COVID drug discovery
-
The Plant Cuticle: An Ancient Guardian Barrier Set Against Long-Standing Rivals
-
ABCG transporters export cutin precursors for the formation of the plant cuticle
-
Community-Wide Experimental Evaluation of the PROSS Stability-Design Method
-
Alternative splicing of the inhibitory immune checkpoint receptor SLAMF6 generates a dominant positive form, boosting T-cell effector functions
-
Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance
-
Cross-reactive antibodies against human coronaviruses and the animal coronavirome suggest diagnostics for future zoonotic spillovers
-
Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies
-
The prospects of tumor chemosensitivity testing at the single-cell level
-
TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer
-
Distinct extracellular–matrix remodeling events precede symptoms of inflammation
-
Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models
-
The AbDesign computational pipeline for modular backbone assembly and design of binders and enzymes
-
Coordinated regulation of WNT/β-catenin, c-Met, and integrin signalling pathways by miR-193b controls triple negative breast cancer metastatic traits
-
Proteomic patterns associated with response to breast cancer neoadjuvant treatment
-
Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction
-
CircRNAs: role in human diseases and potential use as biomarkers
-
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis
-
Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry
-
The key roles of cancer stem cell-derived extracellular vesicles
-
SARS-CoV-2 suppresses IFN[beta] production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon
-
EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired Resistance
-
Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill
-
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo
-
Antiviral activity of bacterial TIR domains via immune signalling molecules
-
The Metabolomic-Gut-Clinical Axis of Mankai Plant-Derived Dietary Polyphenols
-
An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 M pro inhibitor
-
Computationally designed pyocyanin demethylase acts synergistically with tobramycin to kill recalcitrant Pseudomonas aeruginosa biofilms
-
Roles for growth factors and mutations in metastatic dissemination
-
The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance
-
Cancer-associated fibroblasts promote aggressive gastric cancer phenotypes via heat shock factor 1-mediated secretion of extracellular vesicles
-
Steroidal Alkaloids Defense Metabolism and Plant Growth are Modulated by the Joint Action of Gibberellin and Jasmonate Signaling
-
Astrocytes in Multiple Sclerosis—Essential Constituents with Diverse Multifaceted Functions
-
Computational Enzyme Engineering Pipelines for Optimized Production of Renewable Chemicals
-
ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation
-
Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells
-
Extracellular Vesicles From Epicardial Fat Facilitate Atrial Fibrillation
-
SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution
-
Catch-22 in specialized metabolism: balancing defense and growth
-
The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against viral variants
-
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
-
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages
-
Host-Dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors
-
Editorial: Extracellular Vesicles in Infectious Diseases
-
Prokaryotic viperins produce diverse antiviral molecules
-
Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation
-
Electrophilic Natural Products as Drug Discovery Tools
-
SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity
-
Covalent fragment screening
-
Effector-mediated membrane disruption controls cell death in CBASS antiphage defense
-
Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida
-
Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anti-cancer activities in lung adenocarcinoma
-
Discovery of SARS-CoV-2 main protease inhibitors using a synthesis-directed de novo design model
-
Hemopressin as a breakthrough for the cannabinoid field
-
PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR
-
Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration
-
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53
-
Neuroprotective Effect of Glatiramer Acetate on Neurofilament Light Chain Leakage and Glutamate Excess in an Animal Model of Multiple Sclerosis
-
Developmental programs interact with abscisic acid to coordinate root suberization in Arabidopsis
-
Titration of myelin oligodendrocyte glycoprotein (MOG) - Induced experimental autoimmune encephalomyelitis (EAE) model
-
Integrated metabolomics and proteomics of symptomatic and early pre-symptomatic states of colitis
-
Peptide Interference with APP and Tau Association: Relevance to Alzheimer's Disease Amelioration
-
Mutant p53 oncogenicity: dominant-negative or gain-of-function?
-
Structural basis for producing selective MAP2K7 inhibitors
-
Targeting HER3, a Catalytically Defective Receptor Tyrosine Kinase, Prevents Resistance of Lung Cancer to a Third-Generation EGFR Kinase Inhibitor
-
Rational design of universal immunotherapy for TfR1-tropic arenaviruses
-
One-step sequence and structure-guided optimization of HIV-1 envelope gp140
-
Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts
-
Immunomodulatory Properties of Leishmania Extracellular Vesicles During Host-Parasite Interaction: Differential Activation of TLRs and NF-kappa B Translocation by Dermotropic and Viscerotropic Species
-
High mass resolution, spatial metabolite mapping enhances the current plant gene and pathway discovery toolbox
-
Assembly Mechanism of Mucin and von Willebrand Factor Polymers
-
Time-resolved profiling reveals ATF3 as a novel mediator of endocrine resistance in breast cancer
-
‘Hijacking’ core metabolism: a new panache for the evolution of steroidal glycoalkaloids structural diversity
-
Structural Basis for a Convergent Immune Response against Ebola Virus
-
Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients
-
Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models
-
Metabolomics should be deployed in the identification and characterization of gene-edited crops
-
Structure and Electron-Transfer Pathway of the Human Methionine Sulfoxide Reductase MsrB3
-
Emerging roles of ECM remodeling processes in cancer
-
Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody
-
The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy
-
The ECM path of senescence in aging: components and modifiers
-
The pan-immune system of bacteria: antiviral defence as a community resource
-
Influenza virus infection augments susceptibility to respiratory Yersinia pestis exposure and impacts the efficacy of antiplague antibiotic treatments
-
Enhanced collagen deposition in the duodenum of patients with hyaline fibromatosis syndrome and protein losing enteropathy
-
Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells
-
In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors
-
Intravital imaging of vascular anomalies and extracellular matrix remodeling in orthotopic pancreatic tumors
-
A Division of Labor between YAP and TAZ in Non-Small Cell Lung Cancer
-
Rhizosphere microbiome mediates systemic root metabolite exudation by root-to-root signaling
-
Directed evolution of therapeutic antibodies targeting glycosylation in cancer
-
Differential tissue stiffness of body column facilitates locomotion of Hydra on solid substrates
-
Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems
-
Trypanosoma cruzi-Infected Human Macrophages Shed Proinflammatory Extracellular Vesicles That Enhance Host-Cell Invasion via Toll-Like Receptor 2
-
Different inhibitors of Aβ42-induced toxicity have distinct metal-ion dependency
-
Peptide-based quorum sensing systems in Paenibacillus polymyxa
-
Glatiramer acetate increases T- and B -regulatory cells and decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) in an animal model of multiple sclerosis
-
Practically useful protein-design methods combining phylogenetic and atomistic calculations
-
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
-
Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma
-
Abortive Infection: Bacterial Suicide as an Antiviral Immune Strategy
-
The isocitrate dehydrogenase 1 gene is associated with the climacteric response in tomato fruit ripening
-
A Fast and Clean BTK Inhibitor
-
Roles for receptor tyrosine kinases in tumor progression and implications for cancer treatment
-
Efficient targeted degradation via reversible and irreversible covalent PROTACs
-
Antibody-free labeling of malaria-derived extracellular vesicles using flow cytometry
-
STING cyclic dinucleotide sensing originated in bacteria
-
Crowdsourcing drug discovery for pandemics
-
Hitting KRAS When It’s Down
-
Schistosomal extracellular vesicle-enclosed miRNAs modulate host T helper cell differentiation
-
LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis
-
Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5
-
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers
-
Plant terpenoid metabolism co-opts a component of the cell wall biosynthesis machinery
-
Generalized logistic growth modeling of the COVID-19 pandemic in Asia
-
Bacterial Retrons Function In Anti-Phage Defense
-
Extracellular vesicles in parasite survival
-
Inhibition of a pancreatic cancer model by cooperative pairs of clinically approved and experimental antibodies
-
Widespread Utilization of Peptide Communication in Phages Infecting Soil and Pathogenic Bacteria
-
Novel Approaches for Extracellular Matrix Targeting in Disease Treatment
-
Indole derivatives maintain the status quo between beneficial biofilms and their plant hosts
-
Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor
-
Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases
-
Pan-Genomic Illumination of Tomato Identifies Novel Gene-Trait Interactions
-
AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer
-
A rhlI 5' UTR-Derived sRNA Regulates RhlR-Dependent Quorum Sensing in Pseudomonas aeruginosa
-
Stress response as implemented by hibernating ribosomes: a structural overview
-
Chance and pleiotropy dominate genetic diversity in complex bacterial environments
-
Tuberculosis's cargoman: bacteria load RNA into host extracellular vesicles
-
Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient
-
Liver and Steroid Hormones - Can a Touch of p53 Make a Difference?
-
Variations in Core Packing of GP2 from Old World Mammarenaviruses in their Post-Fusion Conformations Affect Membrane-Fusion Efficiencies
-
Early disruption of the alveolar-capillary barrier in a ricin-induced ARDS mouse model: neutrophil-dependent and -independent impairment of junction proteins
-
Dose-Dependent Differences in HIV Inhibition by Different Interferon Alpha Subtypes While Having Overall Similar Biologic Effects
-
The ADAM17 Protease Promotes Tobacco Smoke Carcinogen-induced Lung Tumourigenesis
-
A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation
-
Glatiramer Acetate: from Bench to Bed and Back
-
The circRNA-microRNA code: emerging implications for cancer diagnosis and treatment
-
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces
-
Cancer immunotherapy: The dawn of antibody cocktails
-
3D mapping of native extracellular matrix reveals cellular responses to the microenvironment
-
cis-Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures
-
Structure of Pseudomonas aeruginosa ribosomes from an aminoglycoside-resistant clinical isolate
-
CRISPR/Cas9-based Knockout Strategy Elucidates Components Essential for Type 1 Interferon Signaling in Human HeLa Cells
-
Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis
-
ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer
-
Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses
-
Overcoming insecticide resistance through computational inhibitor design
-
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
-
Differential antibody-based immune response against isolated GP1 receptor-binding domains from Lassa and Junín viruses
-
Collagen: Methods and protocols
-
New insights into YAP/TAZ nucleo-cytoplasmic shuttling: new cancer therapeutic opportunities?
-
In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids
-
Cognitive impairment in an animal model of multiple sclerosis and its amelioration by glatiramer acetate
-
Exosomes as a storehouse of tissue remodeling proteases and mediators of cancer progression
-
MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy
-
Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes
-
Cyclic GMP-AMP signalling protects bacteria against viral infection
-
ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma
-
Demystifying the extracellular matrix and its proteolytic remodeling in the brain: structural and functional insights
-
Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer
-
Mutant p53-a potential player in shaping the tumor-stroma crosstalk
-
p53 balances between tissue hierarchy and anarchy
-
Highlights of the mini-symposium on extracellular vesicles in inter-organismal communication, held in Munich, Germany, August 2018
-
Exit tunnel modulation as resistance mechanism of S. aureus erythromycin resistant mutant
-
Appropriate Thiamin Pyrophosphate Levels Are Required for Acclimation to Changes in Photoperiod
-
Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV
-
Targeting Spt5-Pol II by Small-Molecule Inhibitors Uncouples Distinct Activities and Reveals Additional Regulatory Roles
-
Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression
-
Tracking Root Interactions System (TRIS) Experiment and Quality Control
-
Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy
-
p53 and the Viral Connection: Back into the Future
-
Transcriptome and Metabolic Profiling Provides Insights into Betalain Biosynthesis and Evolution in Mirabilis jalapa
-
Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers
-
Short-chain dehydrogenase/reductase governs steroidal specialized metabolites structural diversity and toxicity in the genus Solanum
-
Extracellular vesicles from early stage Plasmodium falciparum-infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes
-
Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo
-
Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication
-
Astrocyte disruption of neurovascular communication is linked to cortical damage in an animal model of multiple sclerosis
-
Structural basis for receptor recognition by Lujo virus
-
Viruses cooperate to defeat bacteria
-
HflXr, a homolog of a ribosome-splitting factor, mediates antibiotic resistance
-
Chemistry and Enzymology of Disulfide Cross-Linking in Proteins
-
A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen
-
DISARM is a widespread bacterial defence system with broad anti-phage activities
-
WRKY1 acts as a key component improving resistance against Alternaria solani in wild tomato, Solanum arcanum Peralta
-
Automated Design of Efficient and Functionally Diverse Enzyme Repertoires
-
Highly active enzymes by automated combinatorial backbone assembly and sequence design
-
Efficient in planta gene targeting in tomato using geminiviral replicons and the CRISPR/Cas9 system
-
The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery
-
Quiescin sulfhydryl oxidase 1 (QSOX1) glycosite mutation perturbs secretion but not Golgi localization
-
Mining Plants for Bacterial Quorum Sensing Modulators
-
A novel role for the interleukin-1 receptor axis in resistance to anti-EGFR therapy
-
Probing cellular mechanics with acoustic force spectroscopy
-
Bacterial Noncoding RNAs Excised from within Protein-Coding Transcripts
-
Phagocyte-extracellular matrix crosstalk empowers tumor development and dissemination
-
Contemporary Challenges in Medical Usage of Antibiotics
-
Extensive reshaping of bacterial operons by programmed mRNA decay
-
Principles of Protein Stability and Their Application in Computational Design
-
Bacterial virulence against an oceanic bloom-forming phytoplankter is mediated by algal DMSP
-
"La Vie en Rose'': Biosynthesis, Sources, and Applications of Betalain Pigments
-
Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 angstrom resolution
-
A Combination of Approved Antibodies Overcomes Resistance of Lung Cancer to Osimertinib by Blocking Bypass Pathways
-
A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation
-
Live cyanobacteria produce photocurrent and hydrogen using both the respiratory and photosynthetic systems
-
A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells
-
LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state
-
High-resolution RNA 3'-ends mapping of bacterial Rho-dependent transcripts
-
Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models
-
Monitoring extracellular Vesicle Cargo Active Uptake by Imaging Flow Cytometry
-
Emerging insights into the role of matrix metalloproteases as therapeutic targets in fibrosis
-
An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors
-
TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma
-
Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli
-
Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface
-
The HTLV-1 gp21 fusion peptide inhibits antigen specific T-cell activation in-vitro and in mice
-
Systematic discovery of antiphage defense systems in the microbial pangenome
-
Design and in vitro realization of carbon-conserving photorespiration
-
Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange
-
Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner
-
Nanomechanics of Extracellular Vesicles Reveals Vesiculation Pathways
-
MiRNA-513a-5p inhibits progesterone receptor expression and constitutes a risk factor for breast cancer: The hOrmone and Diet in the ETiology of breast cancer prospective study
-
Selecting for Fast Protein-Protein Association As Demonstrated on a Random TEM1 Yeast Library Binding BLIP
-
Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features
-
Malaria Parasites Distribute Subversive Messages across Enemy Lines
-
Pathogen-derived extracellular vesicles coordinate social behaviour and host manipulation
-
Let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery
-
Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism
-
The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis
-
Live imaging of root-bacteria interactions in a microfluidics setup
-
The polyketide synthase OsPKS2 is essential for pollen exine and Ubisch body patterning in rice
-
Metabolic Flexibility Underpins Growth Capabilities of the Fastest Growing Alga
-
Communication between viruses guides lysis-lysogeny decisions
-
Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation
-
CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes
-
The short and the long: non-coding RNAs and growth factors in cancer progression
-
Effective cell-free drug screening protocol for protein-protein interaction
-
P53 on the crossroad between regeneration and cancer
-
Schistosomal MicroRNAs Isolated From Extracellular Vesicles in Sera of Infected Patients: A New Tool for Diagnosis and Follow-up of Human Schistosomiasis
-
Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers
-
Immune deficiency augments the prevalence of p53 loss of heterozygosity in spontaneous tumors but not bi-directional loss of heterozygosity in bone marrow progenitors
-
Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs
-
Next generation matrix metalloproteinase inhibitors — Novel strategies bring new prospects
-
Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis
-
A Bright Future for Antibiotics?
-
Structural Basis for Receptor Selectivity by the Whitewater Arroyo Mammarenavirus
-
Solvent water interactions within the active site of the membrane type I matrix metalloproteinase
-
Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival
-
The extracellular matrix protein agrin promotes heart regeneration in mice
-
The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus
-
Pathogen and pest responses are altered due to RNAi-mediated knockdown of GLYCOALKALOID METABOLISM 4 in solanum tuberosum
-
The landscape of sex-differential transcriptome and its consequent selection in human adults
-
Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus
-
Increased potency of a bi-specific TL1A-ADAM17 (TACE) inhibitor by cell surface targeting
-
Repression of CYSTATHIONINE γ-SYNTHASE in seeds recruits the S-methylmethionine cycle
-
One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen
-
The PhytoClust tool for metabolic gene clusters discovery in plant genomes
-
Structural basis for linezolid binding site rearrangement in the Staphylococcus aureus ribosome
-
Identification and Characterization of Differentially-Regulated Type IVb Pilin Genes Necessary for Predation in Obligate Bacterial Predators /631/326/1320 /631/326/325 /38 article
-
Regulation of antibiotic-resistance by non-coding RNAs in bacteria
-
Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution
-
Principles for computational design of binding antibodies
-
Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases
-
Quantifying enzyme activity in living cells
-
The molecular basis for differential type i interferon signaling
-
Dynamic metabolic reprogramming of steroidal glycol-alkaloid and phenylpropanoid biosynthesis may impart early blight resistance in wild tomato (Solanum arcanum Peralta)
-
Pancreatic cancer ascites xenograft-an expeditious model mirroring advanced therapeutic resistant disease
-
Vesicles Spread Susceptibility to Phages
-
Optimality and sub-optimality in a bacterial growth law
-
The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel
-
Identification and classification of the malaria parasite blood developmental stages, using imaging flow cytometry
-
Improved antibody-based ricin neutralization by affinity maturation is correlated with slower off-rate values
-
Matrix metalloproteinases: The sculptors of chronic cutaneous wounds
-
Computational prediction of regulatory, premature transcription termination in bacteria
-
Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses
-
Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin
-
Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
-
Small molecules below-ground: the role of specialized metabolites in the rhizosphere
-
Direct determination of enzyme kinetic parameters from single reactions using a new progress curve analysis tool
-
RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer
-
CRISPR-Cas adaptation: Insights into the mechanism of action
-
Role of LAMP1 Binding and pH Sensing by the Spike Complex of Lassa Virus
-
Inspired by nature Designed proteins have structural features resembling those of natural active sites
-
LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer
-
The relationship between the nucleolus and cancer: Current evidence and emerging paradigms
-
Tumor macrophages are pivotal constructors of tumor collagenous matrix
-
The Hippo pathway, p53 and cholesterol
-
Oncogenic mutant p53 gain of function nourishes the vicious cycle of tumor development and cancer stem-cell formation
-
Repeat Size Determination by Two Molecular Rulers in the Type I-E CRISPR Array
-
Mutational and network level mechanisms underlying resistance to anti-cancer kinase inhibitors
-
Interfering with the Dimerization of the ERBB Receptors by Transmembrane Domain-Derived Peptides Inhibits Tumorigenic Growth in Vitro and in Vivo
-
Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells
-
The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation
-
ESMO/ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016
-
Natural selection underlies apparent stress-induced mutagenesis in a bacteriophage infection model
-
Comparative transcriptomics across the prokaryotic tree of life
-
ADAM17 substrate release in proximal tubule drives kidney fibrosis
-
Tumor cell invasion can be blocked by modulators of collagen fibril alignment that control assembly of the extracellular matrix
-
Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding
-
A metabolic gene cluster in the wheat W1 and the barley Cer-cqu loci determines β-diketone biosynthesis and glaucousness
-
2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania
-
An extended cyclic di-GMP network in the predatory bacterium Bdellovibrio bacteriovorus
-
Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma
-
Transcriptome dynamics of a broad host-range cyanophage and its hosts
-
Immunotherapy of cancer: From monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR Review 18
-
Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality
-
An antibody to amphiregulin, an abundant growth factor in patients' fluids, inhibits ovarian tumors
-
Quantifying remyelination in vivo - metabolic labeling of myelin in an animal model of multiple sclerosis
-
A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism
-
Viral infection of the marine alga Emiliania huxleyi triggers lipidome remodeling and induces the production of highly saturated triacylglycerol
-
Harnessing the natural inhibitory domain to control TNF alpha Converting Enzyme (TACE) activity in vivo
-
Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms
-
RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer
-
Targeting mutant p53 for cancer therapy
-
Emerging anti-cancer antibodies and combination therapies targeting HER3/ERBB3
-
Elucidation of the first step in betalain biosynthesis allows the heterologous production of betalain pigments in plants
-
A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors
-
Sample preparation for mass spectrometry imaging of plant tissues: A review
-
A novel allosteric mechanism of NF-κB dimerization and DNA binding targeted by an anti-inflammatory drug
-
Widespread formation of alternative 3' UTR isoforms via transcription termination in archaea
-
MicroRNAs: Non-coding fine tuners of receptor tyrosine kinase signalling in cancer
-
Structural Transition in Myelin Membrane as Initiator of Multiple Sclerosis
-
Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides
-
Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease
-
Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery
-
The combination of trastuzumab and pertuzumab administered at approved doses may delay development of trastuzumab resistance by additively enhancing antibody-dependent cell-mediated cytotoxicity
-
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability
-
Matrix metalloproteinase protein inhibitors: highlighting a new beginning for metalloproteinases in medicine
-
Cellular heterogeneity mediates inherent sensitivity-specificity tradeoff in cancer targeting by Synthetic circuits
-
Ribosomal antibiotics: Contemporary challenges
-
Bortezomib-induced pro-inflammatory macrophages as a potential factor limiting anti-tumour efficacy
-
CRISPR–Cas: Spacer Diversity Determines the Efficiency of Defense
-
Elucidation of the first committed step in betalain biosynthesis enables the heterologous engineering of betalain pigments in plants
-
Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria
-
Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga
-
Assessing remyelination - metabolic labeling of myelin in an animal model of multiple sclerosis
-
The EGFR-HER2 module: A stem cell approach to understanding a prime target and driver of solid tumors
-
Examination of HER3 targeting in cancer using monoclonal antibodies
-
Single-molecule spectroscopy exposes hidden states in an enzymatic electron relay
-
The functional maturation of a disintegrin and metalloproteinase (ADAM) 9, 10, and 17 requires processing at a newly identified proprotein convertase (PC) cleavage site
-
Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth
-
Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples
-
Molecular mechanism for LAMP1 recognition by Lassa virus
-
Erratum: A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism (vol 24, pg 242, 2013)
-
Combining three antibodies nullifies feedback-mediated resistance to erlotinib in lung cancer
-
Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases
-
Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy
-
Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases
-
Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1
-
Multilevel regulation of matrix metalloproteinases in tissue homeostasis indicates their molecular specificity in vivo
-
Cell-cycle progress in obligate predatory bacteria is dependent upon sequential sensing of prey recognition and prey quality cues
-
A robust type I interferon gene signature fromblood RNA defines quantitative but not qualitative differences between three major IFNβ drugs in the treatment of multiple sclerosis
-
P53-dependent non-coding RNA networks in chronic lymphocytic leukemia
-
Altered Levels of Aroma and volatiles by Metabolic Engineering of Shikimate Pathway Genes in Tomato Fruits
-
BREX is a novel phage resistance system widespread in microbial genomes
-
Epigenetic silencing of miR-145-5p contributes to brain metastasis
-
Historic recollections: From polymers and proteins to autoimmunity and cancer.
-
PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells
-
AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences
-
Aptamer Targeting the ERBB2 Receptor Tyrosine Kinase for Applications in Tumor Therapy
-
Cancer immunotherapy: More is (much) better
-
A Recombinant Collagen-mRNA Platform for Controllable Protein Synthesis
-
ECM remodelling in IBD: Innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation
-
Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody
-
Fine tuning of a type 1 interferon antagonist
-
The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages
-
Matrix Metalloproteinase Biology
-
Combined crystal structure of a type I cohesin: Mutation and affinity binding studies reveal structural determinants of Cohesin-dockerin specificities
-
Muscle composition is regulated by a lox-TGFβ feedback loop
-
EGF induces microRNAs that target suppressors of cell migration: MiR-15b targets MTSS1 in breast cancer
-
Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq
-
Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents
-
Receptor tyrosine kinases: Structure, functions and role in human disease
-
Modeling and Predicting Optimal Treatment Scheduling Between the Antiangiogenic Drug Sunitinib and Irinotecan in Preclinical Settings
-
Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer
-
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age
-
Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression
-
P53 orchestrates between normal differentiation and cancer
-
ErbB3-ErbB2 complexes as a therapeutic target in a subset of wild-type BRAF/NRAS cutaneous melanomas
-
CRISPR adaptation biases explain preference for acquisition of foreign DNA
-
Enhanced in vivo efficacy of a type I interferon superagonist with extended plasma half-life in a mouse model of multiple sclerosis
-
EGF receptor family: Twisting targets for improved cancer therapies
-
CD84 is a survival receptor for CLL cells
-
Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation
-
P53: The barrier to cancer stem cell formation
-
Downregulation of microRNAs 145-3p and 145-5p is a long-term predictor of postmenopausal breast cancer risk: The ORDET prospective study
-
Fur is the master regulator of the extraintestinal pathogenic Escherichia coli response to serum
-
Modulation of alternative splicing contributes to cancer development: Focusing on p53 isoforms, p53β and p53γ
-
Oligodendrogenesis and myelinogenesis during postnatal development effect of glatiramer acetate
-
Tumor suppressor microRNAs: A novel non-coding alliance against cancer
-
Mapping the diatom redox-sensitive proteome provides insight into response to nitrogen stress in the marine environment
-
Ovarian dendritic cells act as a double-edged pro- ovulatory and anti-inflammatory sword
-
The Effect of Zinc on Amyloid beta-protein Assembly and Toxicity: a Mechanistic Investigation
-
Multifaceted activities of type I interferon are revealed by a receptor antagonist
-
Enzyme structure captures four cysteines aligned for disulfide relay
-
Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment
-
An O-methyltransferase modifies accumulation of methylated anthocyanins in seedlings of tomato
-
The Eps1p protein disulfide isomerase conserves classic thioredoxin superfamily amino acid motifs but not their functional geometries
-
ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A
-
Sequential capsule endoscopy of the small bowel for follow-up of patients with known Crohn's disease
-
RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/ SAPK and p38
-
The paradigm of mutant p53-expressing cancer stem cells and drug resistance
-
Present and future breast cancer management-bench to bedside and back: A positioning paper of academia, regulatory authorities and pharmaceutical industry
-
Sequestration of a two-component response regulator by a riboswitch-regulated noncoding RNA
-
Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th critical assessment of techniques for protein structure prediction experiment CASP10
-
Steering tumor progression through the transcriptional response to growth factors and stroma
-
Prediction of substrates for glutathione transferases by covalent docking
-
Parainflammation in cancer
-
Enzymatic turnover of macromolecules generates long-lasting protein-water-coupled motions beyond reaction steady state
-
The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells
-
SEEDSTICK is a Master Regulator of Development and Metabolism in the Arabidopsis Seed Coat
-
SSNMR of biosilica-entrapped enzymes permits an easy assessment of preservation of native conformation in atomic detail
-
Science Signaling Podcast: 27 May 2014
-
Pla2g16 phospholipase mediates gain-of-function activities of mutant p53
-
Small molecules: From structural diversity to signalling and regulatory roles
-
Complex in vitro and in vivo prostate cancer models for the PREDECT consortium
-
Caught in the crossfire: p53 in inflammation
-
In and out: an analysis of epibiotic vs periplasmic bacterial predators
-
An accurate binding interaction model in de novo computational protein design of interactions: If you build it, they will bind
-
Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs
-
Enhanced in vivo efficacy of a long-life type I Interferon superagonist in a mouse model of multiple sclerosis
-
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques
-
Rationally designed macrocyclic peptides as synergistic agonists of LPS-induced inflammatory response
-
Type i interferon responses in rhesus macaques prevent SIV infection and slow disease progression
-
Small molecules that interact with RNA: riboswitch-based gene control and its involvement in metabolic regulation in plants and algae
-
Computational design of a pH-sensitive IgG binding protein
-
Rewiring host lipid metabolism by large viruses determines the fate of Emiliania huxleyi, a bloom-forming alga in the ocean
-
Pathways and therapeutic targets in melanoma
-
The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility
-
Making the surface of fleshy fruit: Biosynthesis, assembly and role of the cuticular layer
-
Enhanced in vivo efficacy using a novel long-life type I interferon variant in a mouse model of multiple sclerosis
-
Unraveling hidden regulatory sites in structurally homologous metalloproteases
-
Inhibition of triple-negative breast cancer models by combinations of antibodies to EGFR
-
CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea
-
Age dependent course of EAE in Aire-/- mice
-
Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer
-
Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles
-
Antibiotics at the Ribosomal Exit Tunnel-Selected Structural Aspects
-
Druggable protein-protein interactions - from hot spots to hot segments
-
A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism
-
p63 Attenuates Epithelial to Mesenchymal Potential in an Experimental Prostate Cell Model
-
The challenges of cellular compartmentalization in plant metabolic engineering
-
Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies
-
Endocytosis and cancer
-
Beta-catenin/HuR post-transcriptional machinery governs cancer stem cell features in response to hypoxia
-
High-resolution metabolic mapping of cell types in plant roots
-
Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning
-
Magnetic resonance imaging characterization of different experimental autoimmune encephalomyelitis models and the therapeutic effect of glatiramer acetate
-
A Global Transcriptional Switch between the Attack and Growth Forms of Bdellovibrio bacteriovorus
-
A secreted disulfide catalyst controls extracellular matrix composition and function
-
Computational evaluation of cellular metabolic costssuccessfully predicts genes whose expression is deleterious
-
Type I interferon signaling is suppressed in Experimental Autoimmune Encephalomyelitis (EAE): Implications for multiple sclerosis
-
Tomato fruits expressing a bacterial feedback-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway possess enhanced levels of multiple specialized metabolites and upgraded aroma
-
'Cancer associated fibroblasts' - more than meets the eye
-
An inhibitory antibody blocks the first step in the dithiol/disulfide relay mechanism of the enzyme QSOX1
-
Peptide docking and structure-based characterization of peptide binding: From knowledge to know-how
-
Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta
-
Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs
-
Diversification of Quiescin sulfhydryl oxidase in a preserved framework for redox relay
-
Differential translation tunes uneven production of operon-encoded proteins
-
Holding a grudge: Persisting anti-phage CRISPR immunity in multiple human gut microbiomes
-
Inhibition of pancreatic carcinoma by homo-and heterocombinations of antibodies against EGF-receptor and its kin HER2/ErbB-2
-
Now at the met: Fine art of reversible sulfoxidation
-
Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3a4 by activating p53
-
Basic cancer research is essential for the success of personalised medicine
-
The locus of microRNA-10b: A critical target for breast cancer insurgence and dissemination
-
P53 Counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition
-
The excludon: a new concept in bacterial antisense RNA-mediated gene regulation
-
By their genes ye shall know them: Genomic signatures of predatory bacteria
-
Targeting ErbB-1 and ErbB-4 in irradiated head and neck cancer: Results of in vitro and in vivo studies
-
Formation of protein complexes in crowded environments-From in vitro to in vivo
-
Emerging themes in the computational design of novel enzymes and protein-protein interfaces
-
Computational design of a protein-based enzyme inhibitor
-
Transcriptome-Wide Mapping of 5-methylcytidine RNA Modifications in Bacteria, Archaea, and Yeast Reveals m5C within Archaeal mRNAs
-
Transcriptional Control by NF-kappa B: Elongation in Focus
-
Orchestration of thiamin biosynthesis and central metabolism by combined action of the thiamin pyrophosphate riboswitch and the circadian clock in Arabidopsis
-
The dynamic disulphide relay of quiescin sulphydryl oxidase
-
RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation
-
Modeling ductal carcinoma in situ: A HER2-Notch3 collaboration enables luminal filling
-
Comparative transcriptomics of pathogenic and non-pathogenic Listeria species
-
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
-
The Direction of Protein Entry into the Proteasome Determines the Variety of Products and Depends on the Force Needed to Unfold Its Two Termini
-
Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis
-
Asymmetric adaptation to indolic and aliphatic glucosinolates in the B and Q sibling species of Bemisia tabaci (Hemiptera: Aleyrodidae)
-
Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential
-
PanDaTox: A tool for accelerated metabolic engineering
-
Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues
-
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
-
Various p53 mutant proteins differently regulate the ras circuit to induce a cancer-related gene signature
-
Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions
-
A vast collection of microbial genes that are toxic to bacteria
-
Relacin, a Novel Antibacterial Agent Targeting the Stringent Response
-
UPLC-MS-based metabolite analysis in tomato
-
Diverse functions of IGF/insulin signaling in malignant and noncancerous prostate cells: proliferation in cancer cells and differentiation in noncancerous cells
-
The ERBB network: At last, cancer therapy meets systems biology
-
Exploring ORFan Domains in Giant Viruses: Structure of Mimivirus Sulfhydryl Oxidase R596
-
RNA-seq analysis of small RNPs in Trypanosoma brucei reveals a rich repertoire of non-coding RNAs
-
Cancer cells cue the p53 response of cancer-associated fibroblasts to cisplatin
-
A crossroad of microRNAs and immediate early genes (IEGs) encoding oncogenic transcription factors in breast cancer
-
miR-10b*, a master inhibitor of the cell cycle, is down-regulated in human breast tumours
-
N-methylation of isopeptide bond as a strategy to resist deubiquitinases
-
Co-mapping studies of QTLs for fruit acidity and candidate genes of organic acid metabolism and proton transport in sweet melon (Cucumis melo L.)
-
Reconstruction of Arabidopsis metabolic network models accounting for subcellular compartmentalization and tissue-specificity
-
Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression
-
Identification of CTCF as a master regulator of the clustered protocadherin genes
-
Cancer research, a field on the verge of a paradigm shift?
-
Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species
-
CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome
-
Disulfide Bonding in Protein Biophysics
-
Expression of a bacterial feedback-insensitive 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway in Arabidopsis elucidates potential metabolic bottlenecks between primary and secondary metabolism
-
Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation
-
A recombinant decoy comprising EGFR and ErbB-4 inhibits tumor growth and metastasis
-
Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons
-
Fruit cuticular and agronomic characteristics of a lecer6 mutant of tomato
-
Phylogenetics and enzymology of plant quiescin sulfhydryl oxidase
-
DSIF Restricts NF-κB Signaling by Coordinating Elongation with mRNA Processing of Negative Feedback Genes
-
DePICTing p53 activation: A new nucleolar link to cancer
-
TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model
-
Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression
-
Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model
-
Overview of Vaccine Strategies
-
Distinct pathological patterns in relapsing-remitting and chronic models of experimental autoimmune enchephalomyelitis and the neuroprotective effect of glatiramer acetate
-
Ribosome crystallography: From early evolution to contemporary medical insights
-
Mutant p53 gain of function is interwoven into the hallmarks of cancer
-
Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit
-
The aconitase C-terminal domain is an independent dual targeting element
-
The biological framework: translational research from bench to clinic.
-
Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation
-
Bacterial genomes: From regulatory complexity to engineering
-
Convergence of Logic of Cellular Regulation in Different Premalignant Cells by an Information Theoretic Approach
-
Structure of a baculovirus sulfhydryl oxidase, a highly divergent member of the erv flavoenzyme family
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The glial scar-monocyte interplay: A pivotal resolution phase in spinal cord repair
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Stochastic receptor expression determines cell fate upon interferon treatment
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Understanding wild-type and mutant p53 activities in human cancer: New landmarks on the way to targeted therapies
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Beneficial effect of glatiramer acetate treatment on syndecan-1 expression in dextran sodium sulfate colitis
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E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes
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Binding and activity of all human alpha interferon subtypes
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New opportunities in drug design of metalloproteinase inhibitors: combination between structure-function experimental approaches and systems biology
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Probing conformational variations at the ATPase site of the RNA helicase DbpA by high-field electron-nuclear double resonance spectroscopy
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Activity, specificity and structure of I-Bth0305I: A representative of a new homing endonuclease family
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Peptides and Polypeptides as Immunomodulators and Their Consequential Therapeutic Effect in Multiple Sclerosis and Other Autoimmune Diseases
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Computational design of proteins targeting the conserved stem region of influenza hemagglutinin
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Metabolic engineering of the plant primary-secondary metabolism interface
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Two Phases of Mitogenic Signaling Unveil Roles for p53 and EGR1 in Elimination of Inconsistent Growth Signals
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Distinct molecular regulation of glycogen synthase kinase-3α isozyme controlled by its N-terminal region functional role in CALCIUM/CALPAIN signaling
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The phage-host arms race: Shaping the evolution of microbes
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Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation
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Protein binding specificity versus promiscuity
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Glatiramer acetate (GA, Copolymer-1) an hypothetical treatment option for Rett syndrome
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Anchoring of bacterial effectors to host membranes through host-mediated lipidation by prenylation: a common paradigm
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Genomic island variability facilitates Prochlorococcusvirus coexistence
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Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer
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Unleash the wild type: Restoration of p53 suppressive activity in skin cancer
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Structural linkage between ligand discrimination and receptor activation by Type i interferons
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Combining epitope-distinct antibodies to HER2: Cooperative inhibitory effects on invasive growth
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P53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes
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Simultaneous inhibition of estrogen receptor and the HER2 pathway in breast cancer: Effects of HER2 abundance
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Mutant p53 gain-of-function in cancer.
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The ribosome as drug target: lessons from 3D structures
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P53 is balancing development, differentiation and de-differentiation to assure cancer prevention
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Substrate Competitive GSK-3 Inhibitors {single bond} strategy and Implications
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Self-targeting by CRISPR: Gene regulation or autoimmunity?
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Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53
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Steps in reductive activation of the disulfide-generating enzyme Ero1p
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Tailored cancer immunotherapy using combinations of chemotherapy and a mixture of antibodies against EGF-receptor ligands
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The Rebirth of a Phoenix: Ovarian Cancers Are Addicted to ErbB-3
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The EGFR/ErbB family in Breast cancer: From signalling to therapy
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Cytokine-receptor interactions as drug targets
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Polar bears, antibiotics, and the evolving ribosome (nobel lecture)
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Prokaryotic transcriptomics: A new view on regulation, physiology and pathogenicity
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A novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype
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Repression of transposable-elements - a microRNA anti-cancer defense mechanism?
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Direct visualization of protease action on collagen triple helical structure
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Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing-remitting or chronic EAE
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Structural and functional bases for allosteric control of MMP activities: Can it pave the path for selective inhibition?
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The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics
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Oncogenic mutant forms of EGFR: Lessons in signal transduction and targets for cancer therapy
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Sub-angstrom modeling of complexes between flexible peptides and globular proteins
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Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling
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p53 regulates the ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways
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A small molecule inhibitor of Endoplasmic Reticulum Oxidation 1 (ERO1) with selectively reversible thiol reactivity
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Ancient machinery embedded in the contemporary ribosome
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Mutation detection with next-generation resequencing through a mediator genome
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TAF4b and Jun/activating protein-1 collaborate to regulate the expression of integrin α6 and cancer cell migration properties
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The HER2 and EGFR alliance in cancer: defects in system control
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p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation
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An orange ripening mutant links plastid NAD(P)H dehydrogenase complex activity to central and specialized metabolism during tomato fruit maturation
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Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma
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Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions?
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Reduced interferon receptor levels resulting from either knockdown or prolonged Type I interferon treatment promote a shift in cellular responsiveness
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Involvement of stromal p53 in tumor-stroma interactions
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Roles for Growth Factors in Cancer Progression
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Hunting for Alternative Disulfide Bond Formation Pathways: Endoplasmic Reticulum Janitor Turns Professor and Teaches a Lesson
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Role of magnesium ion in the stabilization of biogenic amorphous calcium carbonate: A structure-function investigation
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QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains
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Cytosolic disulfide bond formation in cells infected with large nucleocytoplasmic DNA viruses
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Splicing of the mycobacteriophage bethlehem DnaB intein: Identification of a new mechanistic class of inteins that contain an obligate block f nucleophile
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The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines
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P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss
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Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site
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The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function
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The biological framework: translational research from bench to clinic.
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A single-base resolution map of an archaeal transcriptome
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A comparison of the binding of Interferon alpha subtypes to isolated IFNAR1 and IFNAR2 with activity in antiviral and antiproliferative assays