• Extracellular vesicles in parasite survival

    Yifat Ofir-Birin; Neta Regev-Rudzki (2019)
  • Indole derivatives maintain the status quo between beneficial biofilms and their plant hosts

    Hadas Ganin; Natalie Kemper; Sagit Meir; Ilana Rogachev; Shir Ely; Hassan Massalha; Aviad Mandabi; Alona Keren-Paz; Avraham Shanzer; Michael Meijler; Sergey Malitsky; Asaph Aharoni; Ilana Kolodkin-Gal (2019)
  • Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor

    Amit Shraga; Evgenia Olshvang; Natalia Davidzohn; Payam Khoshkenar; Nicolas Germain; Khriesto Shurrush; Silvia Carvalho; Liat Avram; Shira Albeck; Tamar Unger; Bruce Lefker; Chakrapani Subramanyam; Robert L. Hudkins; Amir Mitchell; Ziv Shulman; Takayoshi Kinoshita; Nir London (2019)
  • Chance and pleiotropy dominate genetic diversity in complex bacterial environments

    Lianet Noda-García; Dan Davidi; Elisa Korenblum; Assaf Elazar; Ekaterina Putintseva; Asaph Aharoni; Dan S. Tawfik (2019)
  • Tuberculosis's cargoman: bacteria load RNA into host extracellular vesicles

    Mirit Biton; Paula Abou Karam; Neta Regev-Rudzki (2019)
  • Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient

    Diana Averbuch; Rifaat Safadi; Daniel Dar; Dana Wolf; Meir Cherniak; Rotem Sorek; Sharon Amit (2019)
  • A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation

    Gal Chaim Nuta; Yuval Gilad; Moran Gershoni; Arielle Sznajderman; Tomer Schlesinger; Shani Bialik; Miriam Eisenstein; Shmuel Pietrokovski; Adi Kimchi (2019)
  • 3D mapping of native extracellular matrix reveals cellular responses to the microenvironment

    Zipora Lansky; Yael Mutsafi; Lothar Houben; Tal Ilani; Gad Armony; Sharon G. Wolf; Deborah Fass (2019)
  • ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

    Mohamed I Saad; Sultan Alhayyani; Louise McLeod; Liang Yu; Mohammad Alanazi; Virginie Deswaerte; Ke Tang; Thierry Jarde; Julian A Smith; Zdenka Prodanovic; Michelle D Tate; Jesse J Balic; D Neil Watkins; Jason E Cain; Steven Bozinovski; Elizabeth Algar; Tomohiro Kohmoto; Hiromichi Ebi; Walter Ferlin; Christoph Garbers; Saleela Ruwanpura; Irit Sagi; Stefan Rose-John; Brendan J Jenkins (2019)
  • Erratum: Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes (vol 39, e00441-18, 2019)

    Urmila Sehrawat; Femke Koning; Shaked Ashkenazi; Gil Stelzer; Dena Leshkowitz; Rivka Dikstein (2019)
  • Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes

    Urmila Sehrawat; Femke Koning; Shaked Ashkenazi; Gil Stelzer; Dena Leshkowitz; Rivka Dikstein (2019)
  • Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer

    Jagmohan Hooda; Marian Novak; Matthew P. Salomon; Chikako Matsuba; Romela I. Ramos; Emily MacDuffie; Melissa Song; Michelle S. Hirsch; Jenny Lester; Vinita Parkash; Beth Y. Karlan; Moshe Oren; Dave S. Hoon; Ronny Drapkin (2019)
  • Appropriate thiamin pyrophosphate levels are required for acclimation to changes in photoperiod

    Laise Rosado-Souza; Sebastian Proost; Michael Moulin; Susan Bergmann; Samuel Bocobza; Asaph Aharoni; Teresa B Fitzpatrick; Marek Mutwil; Alisdair R Fernie; Toshihiro Obata (2019)
  • Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers

    Hilla Solomon; Nathan Dinowitz; Ioannis S. Pateras; Tomer Cooks; Yoav Shetzer; Alina Molchadsky; Meital Charni; Stav Rabani; Gabriela Koifman; Ohad Tarcic; Ziv Porat; Ira Kogan-Sakin; Naomi Goldfinger; Moshe Oren; Curtis C. Harris; Vassilis G. Gorgoulis; Varda Rotter (2018)
  • Short-chain dehydrogenase/reductase governs steroidal specialized metabolites structural diversity and toxicity in the genus Solanum

    Prashant D. Sonawane; Uwe Heinig; Sayantan Panda; Netta Segal Gilboa; Meital Yona; S. Pradeep Kumar; Noam Alkan; Tamar Unger; Samuel Bocobza; Margarita Pliner; Sergey Malitsky; Maria Tkachev; Sagit Meir; Ilana Rogachev; Asaph Aharoni (2018)
  • Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication

    Krystelle Nganou-Makamdop; James M. Billingsley; Zachary Yaffe; Gregory O'Connor; Gregory K. Tharp; Amy Ransier; Farida Laboune; Rodrigo Matus-Nicodemos; Andrea Lerner; Lavina Gharu; Jennifer M. Robertson; Mandy L. Ford; Martin Schlapschy; Nadine Kuhn; Alexandra Lensch; Jeffrey Lifson; Martha Nason; Arne Skerra; Gideon Schreiber; Steven E. Bosinger; Daniel C. Douek (2018)
  • Astrocyte disruption of neurovascular communication is linked to cortical damage in an animal model of multiple sclerosis

    Raya Eilam; Menahem Segal; Rafael Malach; Michael Sela; Ruth Arnon; Rina Aharoni (2018)
  • Structural basis for receptor recognition by Lujo virus

    Hadas Cohen-Dvashi; Itay Kilimnik; Ron Diskin (2018)
  • Viruses cooperate to defeat bacteria

    Aude Bernheim; Rotem Sorek (2018)
  • DISARM is a widespread bacterial defence system with broad anti-phage activities

    Gal Ofir; Sarah Melamed; Hila Sberro; Zohar Mukamel; Shahar Silverman; Gilad Yaakov; Shany Doron; Rotem Sorek (2018)
  • WRKY1 acts as a key component improving resistance against Alternaria solani in wild tomato, Solanum arcanum Peralta

    Balkrishna A Shinde; Bhushan B Dholakia; Khalid Hussain; Asaph Aharoni; Ashok P Giri; Avinash C Kamble (2018)
  • Automated Design of Efficient and Functionally Diverse Enzyme Repertoires

    Olga Khersonsky; Rosalie Lipsh; Ziv Avizemer; Yacov Ashani; Moshe Goldsmith; Haim Leader; Orly Dym; Shelly Rogotner; Devin L. Trudeau; Jaime Prilusky; Pep Amengual-Rigo; Victor Guallar; Dan S. Tawfik; Sarel J. Fleishman (2018)
  • Highly active enzymes by automated combinatorial backbone assembly and sequence design

    Gideon Lapidoth; Olga Khersonsky; Rosalie Lipsh; Orly Dym; Shira Albeck; Shelly Rogotner; Sarel J. Fleishman (2018)
  • The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery

    Nikolaos A. Afratis; Mordehay Klepfish; Nikos K. Karamanos; Irit Sagi (2018)
  • Mining Plants for Bacterial Quorum Sensing Modulators

    Shimrit David; Aviad Mandabi; Shaked Uzi; Asaph Aharoni; Michael M. Meijler (2018)
  • Bacterial Noncoding RNAs Excised from within Protein-Coding Transcripts

    Daniel Dar; Rotem Sorek (2018)
  • Phagocyte-extracellular matrix crosstalk empowers tumor development and dissemination

    Chen Varol; Irit Sagi (2018)
  • Extensive reshaping of bacterial operons by programmed mRNA decay

    Daniel Dar; Rotem Sorek (2018)
  • Bacterial virulence against an oceanic bloom-forming phytoplankter is mediated by algal DMSP

    Noa Barak-Gavish; Miguel Jose Frada; Chuan Ku; Peter A. Lee; Giacomo R. DiTullio; Sergey Malitsky; Asaph Aharoni; Stefan J. Green; Ron Rotkopf; Elena Kartvelishvily; Uri Sheyn; Daniella Schatz; Assaf Vardi (2018)
  • A Combination of Approved Antibodies Overcomes Resistance of Lung Cancer to Osimertinib by Blocking Bypass Pathways

    Donatella Romaniello; Luigi Mazzeo; Maicol Mancini; Ilaria Marrocco; Ashish Noronha; Matthew Kreitman; Swati Srivastava; Soma Ghosh; Moshit Lindzen; Tomer Meir Salame; Amir Onn; Jair Bar; Yosef Yarden (2018)
  • A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation

    Eran Kotler; Odem Shani; Guy Goldfeld; Maya Lotan-Pompan; Ohad Tarcic; Anat Gershoni; Thomas A. Hopf; Debora S. Marks; Moshe Oren; Eran Segal (2018)
  • Live cyanobacteria produce photocurrent and hydrogen using both the respiratory and photosynthetic systems

    Gadiel Saper; Dan Kallmann; Felipe Conzuelo; Fangyuan Zhao; Tünde N Tóth; Varda Liveanu; Sagit Meir; Jedrzej Szymanski; Asaph Aharoni; Wolfgang Schuhmann; Avner Rothschild; Gadi Schuster; Noam Adir (2018)
  • LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state

    Noa Furth; Ioannis S. Pateras; Ron Rotkopf; Vassiliki Vlachou; Irina Rivkin; Ina Schmitt; Deborah Bakaev; Anat Gershoni; Elena Ainbinder; Dena Leshkowitz; Randy L. Johnson; Vassilis G. Gorgoulis; Moshe Oren; Yael Aylon (2018)
  • High-resolution RNA 3 '-ends mapping of bacterial Rho-dependent transcripts

    Daniel Dar; Rotem Sorek (2018)
  • Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models

    Waleed Minzel; Avanthika Venkatachalam; Avner Fink; Eric Hung; Guy Brachya; Ido Burstain; Maya Shaham; Amitai Rivlin; Itay Omer; Adar Zinger; Shlomo Elias; Eitan Winter; Paul E. Erdman; Robert W. Sullivan; Leah Fung; Frank Mercurio; Dansu Li; Joseph Vacca; Nathali Kaushansky; Liran Shlush; Moshe Oren; Ross Levine; Eli Pikarsky; Irit Snir-Alkalay; Yinon Ben-Neriah (2018)
  • Emerging insights into the role of matrix metalloproteases as therapeutic targets in fibrosis

    Nikolaos A. Afratis; Moises Selman; Annie Pardo; Irit Sagi (2018)
  • An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors

    Maicol Mancini; Hilah Gal; Nadege Gaborit; Luigi Mazzeo; Donatella Romaniello; Tomer Meir Salame; Moshit Lindzen; Georg Mahlknecht; Yehoshua Enuka; Dominick G. A. Burton; Lee Roth; Ashish Noronha; Ilaria Marrocco; Dan Adreka; Raya Eilam Altstadter; Emilie Bousquet; Julian Downward; Antonio Maraver; Valery Krizhanovsky; Yosef Yarden (2018)
  • Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features

    Sharathchandra Arandkar; Noa Furth; Yair Elisha; Nishanth Belugali Nataraj; Heiko van der Kuip; Yosef Yarden; Walter Aulitzky; Igor Ulitsky; Benjamin Geiger; Moshe Oren (2018)
  • Malaria Parasites Distribute Subversive Messages across Enemy Lines

    Anna Rivkin; Sharon Ben-Hur; Neta Regev-Rudzki (2017)
  • Pathogen-derived extracellular vesicles coordinate social behaviour and host manipulation

    Birin, Yifat Ofir Birin; Meta Heidenreich; Neta Regev-Rudzki (2017)
  • let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery

    A. Spolverini; G. Fuchs; D. R. Bublik; M. Oren (2017)
  • Analysis of the S. cerevisiae family of deubiquitinating enzymes reveals robustness over specificity

    D. Berko; Yael David; Ami Navon (2017)
  • The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis

    Karel Miettinen; Jacob Pollier; Dieter Buyst; Philipp Arendt; Rene Csuk; Sven Sommerwerk; Tessa Moses; Jan Mertens; Prashant D. Sonawane; Laurens Pauwels; Asaph Aharoni; Jose Martins; David R. Nelson; Alain Goossens (2017)
  • Live imaging of root-bacteria interactions in a microfluidics setup

    Hassan Massalha; Elisa Korenblum; Sergey Malitsky; Orr H. Shapiro; Asaph Aharoni (2017)
  • The polyketide synthase OsPKS2 is essential for pollen exine and Ubisch body patterning in rice

    Xiaolei Zhu; Jing Yu; Jianxin Shi; Takayuki Tohge; Alisdair R. Fernie; Sagit Meir; Asaph Aharoni; Dawei Xu; Dabing Zhang; Wanqi Liang (2017)
  • Metabolic Flexibility Underpins Growth Capabilities of the Fastest Growing Alga

    Haim Treves; Omer Murik; Isaac Kedem; Doron Eisenstadt; Sagit Meir; Ilana Rogachev; Jedrzej Szymanski; Nir Keren; Isabel Orf; Antonio F. Tiburcio; Ruben Alcazar; Asaph Aharoni; Joachim Kopka; Aaron Kaplan (2017)
  • Communication between viruses guides lysis-lysogeny decisions

    Zohar Erez; Ida Steinberger-Levy; Maya Shamir; Shany Doron; Avihail, Avigail Stokar Avihail; Yoav Peleg; Sarah Melamed; Azita Leavitt; Alon Savidor; Shira Albeck; Gil Amitai; Rotem Sorek (2017)
  • Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation

    Joshua J. Ziarek; Andrew B. Kleist; Nir London; Barak Raveh; Nicolas Montpas; Julien Bonneterre; Genevieve St-Onge; Crystal J. DiCosmo-Ponticello; Chad A. Koplinski; Ishan Roy; Bryan Stephens; Sylvia Thelen; Christopher T. Veldkamp; Frederick D. Coffman; Marion C. Cohen; Michael B. Dwinell; Marcus Thelen; Francis C. Peterson; Nikolaus Heveker; Brian F. Volkman (2017)
  • The short and the long: non-coding RNAs and growth factors in cancer progression

    Aldema Sas-Chen; Swati Srivastava; Yosef Yarden (2017)
  • Effective cell-free drug screening protocol for protein-protein interaction

    Shaked Ashkenazi; Alexander Plotnikov; Anat Bahat; Rivka Dikstein (2017)
  • p53 on the crossroad between regeneration and cancer

    Meital Charni; Ronit Aloni-Grinstein; Alina Molchadsky; Varda Rotter (2017)
  • Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers

    Moshe Goldsmith; Nidhi Aggarwal; Yacov Ashani; Halim Jubran; Per Jr. Greisen; Sergey Ovchinnikov; Haim Leader; David Baker; Joel Sussman; Adi Goldenzweig; Sarel J. Fleishman; Dan Tawfik (2017)
  • Immune deficiency augments the prevalence of p53 loss of heterozygosity in spontaneous tumors but not bi-directional loss of heterozygosity in bone marrow progenitors

    Yoav Shetzer; Yael Napchan; Tom Kaufman; Alina Molchadsky; Perry Tal; Naomi Goldfinger; Varda Rotter (2017)
  • Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs

    Ohad Yogev; Stephen Henderson; Matthew John Hayes; Sara Sofia Marelli; Birin, Yifat Ofir Birin; Neta Regev-Rudzki; Javier Herrero; Tariq Enver (2017)
  • Diversity of antiviral defense strategies of bacteria at the population level

    A. Lopatina; A. Millman; E. Abram; S. Silverman; Sarah Melamed; Azita Leavitt; Rotem Sorek (2017)
  • Next generation matrix metalloproteinase inhibitors - Novel strategies bring new prospects

    Maxim Levin; Yael Udi; Inna Solomonov; Irit Sagi (2017)
  • Phosphatidylserine externalization, "necroptotic bodies" release, and phagocytosis during necroptosis

    Sefi Zargarian; Inbar Shlomovitz; Ziv Erlich; Aria Hourizadeh; Birin, Yifat Ofir Birin; Ben A. Croker; Neta Regev-Rudzki; Liat Edry-Botzer; Motti Gerlic (2017)
  • A Bright Future for Antibiotics?

    Donna Matzov; Anat Bashan; Ada Yonath (2017)
  • Structural Basis for Receptor Selectivity by the Whitewater Arroyo Mammarenavirus

    Amir Shimon; Orly Shani; Ron Diskin (2017)
  • Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival

    Debora R. Bublik; Sladana Bursac; Michal Sheffer; Ines Orsolic; Tali Shalit; Ohad Tarcic; Eran Kotler; Odelia Mouhadeb; Yonit Hoffman; Gilad Fuchs; Yishai Levin; Sinisa Volarevic; Moshe Oren (2017)
  • The extracellular matrix protein agrin promotes heart regeneration in mice

    Elad Bassat; Yara Eid Mutlak; Alex Genzelinakh; Ilya Y. Shadrin; Kfir-Baruch Umansky; Oren Yifa; David Kain; Dana Rajchman; John Leach; Daria Riabov Bassat; Yael Udi; Rachel Sarig; Irit Sagi; James F. Martin; Nenad Bursac; Shenhav Cohen; Eldad Tzahor (2017)
  • The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus

    Donna Matzov; Shintaro Aibara; Arnab Basu; Ella Zimmerman; Anat Bashan; Mee-Ngan F. Yap; Alexey Amunts; Ada E. Yonath (2017)
  • From mice to men: astrocyte morphology is confined by functional boundaries in the mammalian cortex

    R. Eilam; Rina Aharoni; Ruth Arnon; Rafi Malach (2017)
  • The landscape of sex-differential transcriptome and its consequent selection in human adults

    Moran Gershoni; Shmuel Pietrokovski (2017)
  • Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus

    Donna Matzov; Zohar Eyal; Raphael I. Benhamou; Moran Shalev-Benami; Yehuda Halfon; Miri Krupkin; Ella Zimmerman; Haim Rozenberg; Anat Bashan; Micha Fridman; Ada Yonath (2017)
  • Increased potency of a bi-specific TL1A-ADAM17 (TACE) inhibitor by cell surface targeting

    Tomer Weizman; Itay Levin; Marianna Zaretsky; Irit Sagi; Amir Aharoni (2017)
  • Repression of CYSTATHIONINE gamma-SYNTHASE in Seeds Recruits the S-Methylmethionine Cycle

    Hagai Cohen; Yael Hacham; Irina Panizel; Ilana Rogachev; Asaph Aharoni; Rachel Amir (2017)
  • One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen

    Ivan Campeotto; Adi Goldenzweig; Jack Davey; Lea Barfod; Jennifer M. Marshall; Sarah E. Silk; Katherine E. Wright; Simon J. Draper; Matthew K. Higgins; Sarel J. Fleishman (2017)
  • The PhytoClust tool for metabolic gene clusters discovery in plant genomes

    Nadine Topfer; Lisa-Maria Fuchs; Asaph Aharoni (2017)
  • Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome

    Matthew J. Belousoff; Zohar Eyal; Mazdak Radjainia; Tofayel Ahmed; Rebecca S. Bamert; Donna Matzov; Anat Bashan; Ella Zimmerman; Satabdi Mishra; David Cameron; Hans Elmlund; Anton Y. Peleg; Shashi Bhushan; Trevor Lithgow; Ada Yonath (2017)
  • Identification and Characterization of Differentially-Regulated Type IVb Pilin Genes Necessary for Predation in Obligate Bacterial Predators

    Ofir Avidan; Margarita Petrenko; Rene Becker; Sebastian Beck; Michael Linscheid; Shmuel Pietrokovski; Edouard Jurkevitch (2017)
  • Regulation of antibiotic-resistance by non-coding RNAs in bacteria

    Daniel Dar; Rotem Sorek (2017)
  • Quantifying enzyme activity in living cells

    Agnes Zotter; Felix Baeuerle; Debabrata Dey; Vladimir Kiss; Gideon Schreiber (2017)
  • Dynamic metabolic reprogramming of steroidal glycol-alkaloid and phenylpropanoid biosynthesis may impart early blight resistance in wild tomato (Solanum arcanum Peralta)

    Balkrishna A. Shinde; Bhushan B. Dholakia; Khalid Hussain; Sayantan Panda; Sagit Meir; Ilana Rogachev; Asaph Aharoni; Ashok P. Giri; Avinash C. Kamble (2017)
  • Pancreatic cancer ascites xenograft-an expeditious model mirroring advanced therapeutic resistant disease

    Talia Golan; Chani Stossel; Michael Schvimer; Dikla Atias; Sharon Halperin; Ella Buzhor; Gurevich, Maria Raitses Gurevich; Keren Cohen; Sara Pri-Chen; Julie Wilson; Robert E. Denroche; Ilinca Lungu; John M. S. Bartlett; Faridah Mbabaali; Yosef Yarden; Nishanth Belugali Nataraj; Steven Gallinger; Raanan Berger (2017)
  • Optimality and sub-optimality in a bacterial growth law

    Benjamin D. Towbin; Yael Korem; Anat Bren; Shany Doron; Rotem Sorek; Uri Alon (2017)
  • The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel

    Itai Wekselman; Ella Zimmerman; Chen Davidovich; Matthew Belousoff; Donna Matzov; Miri Krupkin; Haim Rozenberg; Anat Bashan; Gilgi Friedlander; Jette Kjeldgaard; Hanne Ingmer; Lasse Lindahl; Janice M. Zengel; Ada Yonath (2017)
  • Identification and classification of the malaria parasite blood developmental stages, using imaging flow cytometry

    Elya Dekel; Anna Rivkin; Meta Kristin Heidenreich; Yakov Nadav; Birin, Yifat Ofir Birin; Ziv Porat; Neta Regev-Rudzki (2017)
  • Improved antibody-based ricin neutralization by affinity maturation is correlated with slower off-rate values

    Ronit Rosenfeld; Ron Alcalay; Adva Mechaly; Gideon Lapidoth; Eyal Epstein; Chanoch Kronman; Sarel J. Fleishman; Ohad Mazor (2017)
  • Matrix metalloproteinases: The sculptors of chronic cutaneous wounds: The sculptors of chronic cutaneous wounds

    Venkat Raghavan Krishnaswamy; Dvir Mintz; Irit Sagi (2017)
  • Computational prediction of regulatory, premature transcription termination in bacteria

    Adi Millman; Daniel Dar; Maya Shamir; Rotem Sorek (2017)
  • Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses

    Hadar Israeli; Hadas Cohen-Dvashi; Anastasiya Shulman; Amir Shimon; Ron Diskin (2017)
  • Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

    Xavier Sisquella; Yifat Ofir-Birin; Matthew A. Pimentel; Lesley Cheng; Paula Abou Karam; Natalia G. Sampaio; Jocelyn Sietsma Penington; Dympna Connolly; Tal Giladi; Benjamin J. Scicluna; Robyn A. Sharples; Andreea Waltmann; Dror Avni; Eli Schwartz; Louis Schofield; Ziv Porat; Diana S. Hansen; Anthony T. Papenfuss; Emily M. Eriksson; Motti Gerlic; Andrew F. Hill; Andrew G. Bowie; Neta Regev-Rudzki (2017)
  • Small molecules below-ground: the role of specialized metabolites in the rhizosphere

    Hassan Massalha; Elisa Korenblum; Dorothea Tholl; Asaph Aharoni (2017)
  • Direct determination of enzyme kinetic parameters from single reactions using a new progress curve analysis tool

    Felix Baeuerle; Agnes Zotter; Gideon Schreiber (2017)
  • RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer

    Ohad Tarcic; Roy Z Granit; Ioannis S Pateras; Hadas Masury; Bella Maly; Yaara Zwang; Yosef Yarden; Vassilis G Gorgoulis; Eli Pikarsky; Ittai Ben-Porath; Moshe Oren (2017)
  • CRISPR-Cas adaptation: insights into the mechanism of action.

    Gil Amitai; Rotem Sorek (2016)
  • Role of LAMP1 Binding and pH Sensing by the Spike Complex of Lassa Virus

    Hadas Cohen-Dvashi; Hadar Israeli; Orly Shani; Aliza Katz; Ron Diskin (2016)
  • LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer.

    Aldema Sas-Chen; Miriam R Aure; Limor Leibovich; Silvia Carvalho; Yehoshua Enuka; Cindy Korner; Maria Polycarpou-Schwarz; Sara Lavi; Nava Nevo; Yuri Kuznetsov; Justin Yuan; Francisco Azuaje; Igor Ulitsky; Sven Diederichs; Stefan Wiemann; Zohar Yakhini; Vessela N Kristensen; Anne-Lise Borresen-Dale; Yosef Yarden (2016)
  • The relationship between the nucleolus and cancer: Current evidence and emerging paradigms

    Ines Orsolic; Deana Jurada; Nick Pullen; Moshe Oren; Aristides G. Eliopoulos; Sinisa Volarevic (2016)
  • Tumor macrophages are pivotal constructors of tumor collagenous matrix

    Ran Afik; Ehud Zigmond; Milena Vugman; Mordehay Klepfish; Elee Shimshoni; Metsada Pasmanik-Chor; Anjana Shenoy; Elad Bassat; Zamir Halpern; Tamar Geiger; Irit Sagi; Chen Varol (2016)
  • The Hippo pathway, p53 and cholesterol.

    Yael Aylon; Moshe Oren (2016)
  • Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation

    Yoav Shetzer; Alina Molchadsky; Varda Rotter (2016)
  • Repeat Size Determination by Two Molecular Rulers in the Type I-E CRISPR Array

    Moran G. Goren; Shany Doron; Rea Globus; Gil Amitai; Rotem Sorek; Udi Qimron (2016)
  • Mutational and network level mechanisms underlying resistance to anti-cancer kinase inhibitors

    Maicol Mancini; Yosef Yarden (2016)
  • Interfering with the Dimerization of the ErbB Receptors by Transmembrane Domain-Derived Peptides Inhibits Tumorigenic Growth in Vitro and in Vivo

    Erez M. Bublil; Tomer Cohen; Christopher J. Arnusch; Adi Peleg; Gur Pines; Sara Lavi; Yosef Yarden (2016)
  • Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells

    Francesca Grespi; Vivien Landre; Alina Molchadsky; Daniele, Nicola Di Daniele; Luigi Tonino Marsella; Gerry Melino; Varda Rotter (2016)
  • The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.

    Yael Aylon; Anat Gershoni; Ron Rotkopf; Inbal E Biton; Ziv Porat; Anna P Koh; Xiaochen Sun; Youngmin Lee; Maria-Isabel Fiel; Yujin Hoshida; Scott L Friedman; Randy L Johnson; Moshe Oren (2016)
  • ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016

    Christian Dittrich; Michael Kosty; Svetlana Jezdic; Doug Pyle; Rossana Berardi; Jonas Bergh; Nagi El-Saghir; Jean-Pierre Lotz; Pia Osterlund; Nicholas Pavlidis; Gunta Purkalne; Ahmad Awada; Susana Banerjee; Smita Bhatia; Jan Bogaerts; Jan Buckner; Fatima Cardoso; Paolo Casali; Edward Chu; Julia Lee Close; Bertrand Coiffier; Roisin Connolly; Sarah Coupland; Petris, Luigi De Petris; Santis, Maria De Santis; Vries, Elisabeth G. E. de Vries; Don S. Dizon; Jennifer Duff; Linda R. Duska; Alexandru Eniu; Marc Ernstoff; Enriqueta Felip; Martin F. Fey; Jill Gilbert; Nicolas Girard; Andor W. J. M. Glaudemans; Priya K. Gopalan; Axel Grothey; Stephen M. Hahn; Diana Hanna; Christian Herold; Jorn Herrstedt; Krisztian Homicsko; Dennie V., Jr. Jones; Lorenz Jost; Ulrich Keilholz; Saad Khan; Alexander Kiss; Claus-Henning Koehne; Rainer Kunstfeld; Heinz-Josef Lenz; Stuart Lichtman; Lisa Licitra; Thomas Lion; Saskia Litiere; Lifang Liu; Patrick J. Loehrer; Merry Jennifer Markham; Ben Markman; Marius Mayerhoefer; Johannes G. Meran; Olivier Michielin; Elizabeth Charlotte Moser; Giannis Mountzios; Timothy Moynihan; Torsten Nielsen; Yuichiro Ohe; Kjell Oberg; Antonio Palumbo; Fedro Alessandro Peccatori; Michael Pfeilstoecker; Chandrajit Raut; Scot C. Remick; Mark Robson; Piotr Rutkowski; Roberto Salgado; Lidia Schapira; Eva Schernhammer; Martin Schlumberger; Hans-Joachim Schmoll; Lowell Schnipper; Cristiana Sessa; Charles L. Shapiro; Julie Steele; Cora N. Sternberg; Friedrich Stiefel; Florian Strasser; Roger Stupp; Richard Sullivan; Josep Tabernero; Luzia Travado; Marcel Verheij; Emile Voest; Everett Vokes; Roenn, Jamie Von Roenn; Jeffrey S. Weber; Hans Wildiers; Yosef Yarden (2016)
  • Natural selection underlies apparent stress-induced mutagenesis in a bacteriophage infection model

    Ido Yosef; Rotem Edgar; Asaf Levy; Gil Amitai; Rotem Sorek; Ariel Munitz; Udi Qimron; Bruno Mueller; Petr Tarkowski; David Weiss (2016)
  • ADAM17 substrate release in proximal tubule drives kidney fibrosis

    Eirini Kefaloyianni; Muthu Lakshmi Muthu; Jakob Kaeppler; Xiaoming Sun; Venkata Sabbisetti; Athena Chalaris; Stefan Rose-John; Eitan Wong; Irit Sagi; Sushrut S Waikar; Helmut Rennke; Benjamin D Humphreys; Joseph V Bonventre; Andreas Herrlich (2016)
  • Tumor cell invasion can be blocked by modulators of collagen fibril alignment that control assembly of the extracellular matrix.

    Moran Grossman; Chetrit, Nir Ben Chetrit; Alina Zhuravlev; Ran Afik; Elad Bassat; Inna Solomonov; Yosef Yarden; Irit Sagi (2016)
  • Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding

    Miri Krupkin; Itai Wekselman; Donna Matzov; Zohar Eyal; Yael Diskin Posner; Haim Rozenberg; Ella Zimmerman; Anat Bashan; Ada Yonath (2016)
  • A Metabolic Gene Cluster in the Wheat W1 and the Barley Cer-cqu Loci Determines beta-Diketone Biosynthesis and Glaucousness

    Avivi, Shelly Hen Avivi; Orna Savin; Radu C. Racovita; Wing-Sham Lee; Nikolai M. Adamski; Sergey Malitsky; Efrat Almekias-Siegl; Matan Levy; Sonia Vautrin; Helene Berges; Gilgi Friedlander; Elena Kartvelishvily; Gil Ben-Zvi; Noam Alkan; Cristobal Uauy; Kostya Kanyuka; Reinhard Jetter; Assaf Distelfeld; Asaph Aharoni (2016)
  • 2.8-angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania

    Moran Shalev-Benami; Yan Zhang; Donna Matzov; Yehuda Halfon; Arie Zackay; Haim Rozenberg; Ella Zimmerman; Anat Bashan; Charles L. Jaffe; Ada Yonath; Georgios Skiniotis (2016)
  • An Extended Cyclic Di-GMP Network in the Predatory Bacterium Bdellovibrio bacteriovorus

    Or Rotem; Jutta Nesper; Ilya Borovok; Rena Gorovits; Mikhail Kolot; Zohar Pasternak; Irina Shin; Timo Glatter; Shmuel Pietrokovski; Urs Jenal; Edouard Jurkevitch (2016)
  • SLE-KEY (R) ICHIP (R) PLATFORM IDENTIFIES A 'LUPUS AUTO-ANTIBODIES SIGNATURE' EARLY IN DISEASE WHICH PERSISTS INDEPENDENT OF DISEASE DURATION AND ACTIVITY

    Chaim Putterman; P Safer; K Jakobi; Rotem Sorek; I Gilkaite; S Wallace; AH Altice; DS Batty; Irun R. Cohen (2016)
  • Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma.

    Iris Grossman; Tal Ilani; Sarel-Jacob Fleishman; Deborah Fass (2016)
  • Transcriptome dynamics of a broad host-range cyanophage and its hosts

    Shany Doron; Ayalla Fedida; Miguel A. Hernandez-Prieto; Gazalah Sabehi; Iris Karunker; Damir Stazic; Roi Feingersch; Claudia Steglich; Matthias Futschik; Debbie Lindell; Rotem Sorek (2016)
  • Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR Review 18.

    Silvia Carvalho; Francesca Levi-Schaffer; Michael Sela; Yosef Yarden (2016)
  • Extracellular Matrix Proteolysis by MT1-MMP Contributes to InfluenzaInfluenza-Related Tissue Damage and Mortality

    Dalit Talmi-Frank; Zeev Altboum; Inna Solomonov; Tamar Ziv; Ido Amit; Irit Sagi (2016)
  • An antibody to amphiregulin, an abundant growth factor in patients' fluids, inhibits ovarian tumors.

    Silvia Carvalho; Moshit Lindzen; Mattia Lauriola; N Shirazi; Sanchari Sinha; A Abdul-Hai; K Levanon; J Korach; I Barshack; Yonatan Cohen; A Onn; G Mills; Yosef Yarden (2016)
  • Quantifying remyelination in vivo - metabolic labeling of myelin in an animal model of multiple sclerosis

    Rina Aharoni; Chava Rosen; Elias Shezen; M. Sela; Ruth Arnon (2016)
  • A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism

    Zohar Eyal; Donna Matzov; Miri Krupkin; S Paukner; R Riedl; Haim Rozenberg; Ella Zimmerman; Anat Bashan; Ada Yonath (2016)
  • Harnessing the natural inhibitory domain to control TNF alpha Converting Enzyme (TACE) activity in vivo

    Eitan Wong; Tal Cohen; Erez Romi; Maxim Levin; Yoav Peleg; Uri Arad; Avraham Yaron; Marcos E. Milla; Irit Sagi (2016)
  • RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

    Ohad Tarcic; Ioannis S. Pateras; Tomer Cooks; Efrat Shema; Julia Kanterman; Hadas Ashkenazi; Hana Boocholez; Ayala Hubert; Ron Rotkopf; Michal Baniyash; Eli Pikarsky; Vassilis G. Gorgoulis; Moshe Oren (2016)
  • Targeting mutant p53 for cancer therapy

    Moshe Oren; Perry Tal; Varda Rotter (2016)
  • Emerging anti-cancer antibodies and combination therapies targeting HER3/ERBB3

    Nadege Gaborit; Moshit Lindzen; Yosef Yarden (2016)
  • Elucidation of the first step in betalain biosynthesis allows the heterologous production of betalain pigments in plants

    Guy Polturak; D. Breitel; A. Sarrion-Perdigones; Noam Grossman; Efrat Weithorn; Margarita Pliner; D. Orzaez; A. Granell; Ilana Rogachev; A. Aharoni (2016)
  • A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors

    Valerio Gelfo; Maria Teresa Rodia; Michela Pucci; Massimiliano Dall'Ora; Spartaco Santi; Rossella Solmi; Lee Roth; Moshit Lindzen; Massimiliano Bonafe; Andrea Bertotti; Elisabetta Caramelli; Pier-Luigi Lollini; Livio Trusolino; Yosef Yarden; Gabriele D'Uva; Mattia Lauriola (2016)
  • Sample Preparation for Mass Spectrometry Imaging of Plant Tissues: A Review

    Yonghui Dong; Bin Li; Sergey Malitsky; Liana Rogachev; Asaph Aharoni; Filip Kaftan; Ales Svatos; Pietro Franceschi (2016)
  • A Novel Allosteric Mechanism of NF-kappaB Dimerization and DNA Binding Targeted by an Anti-Inflammatory Drug.

    Shaked Ashkenazi; Alexander Plotnikov; Anat Bahat; Efrat Ben-Zeev; Shira Warszawski; Rivka Dikstein (2016)
  • MicroRNAs: Non-coding fine tuners of receptor tyrosine kinase signalling in cancer

    Sara Donzelli; Mario Cioce; Paola Muti; Sabrina Strano; Yosef Yarden; Giovanni Blandino (2016)
  • Structural Transition in Myelin Membrane as Initiator of Multiple Sclerosis

    Rona Shaharabani; Maor Ram-On; Ram Avinery; Rina Aharoni; Ruth Arnon; Yeshayahu Talmon; Roy Beck (2016)
  • Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

    Perry Tal; Shay Eizenberger; Elad Cohen; Naomi Goldfinger; Shmuel Pietrokovski; Moshe Oren; Varda Rotter (2016)
  • Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease.

    Rona Yaeger; Manish A Shah; Vincent A Miller; Judith R Kelsen; Kai Wang; Zachary J Heins; Jeffrey S Ross; Yuting He; Eric Sanford; Rhonda K Yantiss; Sohail Balasubramanian; Philip J Stephens; Nikolaus Schultz; Moshe Oren; Laura Tang; David Kelsen (2016)
  • Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

    Kristin Stock; Marta F. Estrada; Suzana Vidic; Kjersti Gjerde; Albin Rudisch; Vitor E. Santo; Michael Barbier; Sami Blom; Sharath C. Arundkar; Irwin Selvam; Annika Osswald; Yan Stein; Sylvia Gruenewald; Catarina Brito; Weerden, Wytske van Weerden; Varda Rotter; Erwin Boghaert; Moshe Oren; Wolfgang Sommergruber; Yolanda Chong; Hoogt, Ronald de Hoogt; Ralph Graeser (2016)
  • Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

    Adi Goldenzweig; Moshe Goldsmith; Shannon E. Hill; Or Gertman; Paola Laurino; Yacov Ashani; Orly Dym; Tamar Unger; Shira Albeck; Jaime Prilusky; Raquel L. Lieberman; Amir Aharoni; Israel Silman; Joel Sussman; Dan Tawfik; Sarel J. Fleishman (2016)
  • Matrix metalloproteinase protein inhibitors: highlighting a new beginning for metalloproteinases in medicine

    Vishnu Mohan; Dalit Talmi-Frank; Valeria Arkadash; Niv Papo; Irit Sagi (2016)
  • Tumor Evolution Inferred by Patterns of microRNA Expression through the Course of Disease, Therapy, and Recurrence in Breast Cancer

    Maya Dadiani; Noa Bossel Ben-Moshe; Shani Paluch-Shimon; Gili Perry; Nora Balint; Irina Marin; Anya Pavlovski; Anat Bashan; Charles L. Jaffe; Ada Yonath; Georgios Skiniotis (2016)
  • CRISPR-Cas: Spacer Diversity Determines the Efficiency of Defense

    Anna Lopatina; Rotem Sorek (2016)
  • Elucidation of the first committed step in betalain biosynthesis enables the heterologous engineering of betalain pigments in plants

    Guy Polturak; Dario Breitel; Noam Grossman; Alejandro Sarrion-Perdigones; Efrat Weithorn; Margarita Pliner; Diego Orzaez; Antonio Granell; Ilana Rogachev; Asaph Aharoni (2016)
  • Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria

    Daniel Dar; Maya Shamir; J. R. Mellin; Mikael Koutero; Noam Stern-Ginossar; Pascale Cossart; Rotem Sorek (2016)
  • Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga.

    Carmit Ziv; Sergey Malitsky; Alaa Othman; Shifra Ben-Dor; Yu Wei; Shuning Zheng; Asaph Aharoni; Thorsten Hornemann; Assaf Vardi (2016)
  • Cellular heterogeneity mediates inherent sensitivity-specificity tradeoff in cancer targeting by synthetic circuits.

    Mathieu Morel; Roman Shtrahman; Varda Rotter; Lior Nissim; Roy H Bar-Ziv (2016)
  • The EGFR-HER2 module: a stem cell approach to understanding a prime target and driver of solid tumors

    M. R. Schneider; Yosef Yarden (2016)
  • Examination of HER3 targeting in cancer using monoclonal antibodies

    Nadege Gaborit; Ali Abdul-Hai; Maicol Mancini; Moshit Lindzen; Sara Lavi; Orith Leitner; Lucile Mounier; Myriam Chentouf; Sai Dunoyer; Manjusha Ghosh; Christel Larbouret; Thierry Chardes; Herve Bazin; Andre Pelegrine; Michael Sela; Yosef Yarden (2015)
  • Single-molecule spectroscopy exposes hidden states in an enzymatic electron relay.

    Iris Grossman; Aviram, Haim Yuval Aviram; Gad Armony; Amnon Horovitz; Hagen Hofmann; Gilad Haran; Deborah Fass (2015)
  • Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth

    SA Harel; NB Ben-Moshe; Yael Aylon; DR Bublik; Neta Moskovits; G Toperoff; D Azaiza; F Biagoni; Gilad Fuchs; Sylvia Wilder; A Hellman; G Blandino; Eytan Domany; Moshe Oren (2015)
  • Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples.

    Tal Korem; David Zeevi; Jotham Suez; Adina Weinberger; Sagi, Tali Avnit Sagi; Maya Pompan-Lotan; Elad Matot; Ghil Jona; Alon Harmelin; Nadav Cohen; Alexandra Sirota-Madi; Christoph Alexander Thaiss; Meirav Pevsner-Fischer; Rotem Sorek; Ramnik J. Xavier; Eran Elinav; Eran Segal (2015)
  • Diurnal suppression of EGFR signaling by glucocorticoids: implications for tumor progression and treatment

    Mattia Lauriola; Yehoshua Enuka; Amit Zeisel; Gabriele Matteo D'Uva; Lee Roth; Silvia Carvalho; R Solmi; Eytan Domany; Yosef Yarden (2015)
  • Molecular Mechanism for LAMP1 Recognition by Lassa Virus

    Hadas Cohen-Dvashi; Nir Cohen; Hadar Israeli; Ron Diskin (2015)
  • Combining three antibodies nullifies feedback-mediated resistance to erlotinib in lung cancer

    Maicol Mancini; Nadege Gaborit; Moshit Lindzen; TM Salame; M Dall'Ora; Michal Sevilla-Sharon; A Abdul-Hai; J Downward; Yosef Yarden (2015)
  • Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases

    BE Oftedal; A Hellesen; MM Erichsen; E Bratland; Ayelet Vardi; J Perheentupa; EH Kemp; T Fiskerstrand; MK Viken; AP Weetman; SJ Fleishman; S Banka; WG Newman; WAC Sewell; LS Sozaeva; T Zayats; K Haugarvoll; EM Orlova; J Haavik; S Johansson; PM Knappskog; K Lovas; ASB Wolff; Jakub Abramson; ES Husebye (2015)
  • Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy

    Lior Golomb; Adi Sagiv; I.S. Pateras; A. Maly; Valery Krizhanovsky; V.G. Gorgoulis; Moshe Oren; A. Ben-Yehuda (2015)
  • Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1

    Jennifer Vandooren; Benjamin Born; Inna Solomonov; Ewa Zajac; Radka Saldova; Michael Senske; Estefania Ugarte-Berzal; Erik Martens; den Steen, Philippe E. Van den Steen; Damme, Jo Van Damme; Angeles Garcia-Pardo; Matheus Froeyen; Elena I. Deryugina; James P. Quigley; Soren K. Moestrup; Pauline M. Rudd; Irit Sagi; Ghislain Opdenakker (2015)
  • Multilevel Regulation of Matrix Metalloproteinases in Tissue Homeostasis Indicates Their Molecular Specificity in vivo

    Jean Patricia Gaffney; Inna Solomonov; Eldar Zehorai; Irit Sagi (2015)
  • A robust type I interferon gene signature from blood RNA defines quantitative but not qualitative differences between three major IFN beta drugs in the treatment of multiple sclerosis

    Daniel Harari; Irit Orr; Ron Rotkopf; SE Baranzini; Gideon Schreiber (2015)
  • P53-dependent non-coding RNA networks in chronic lymphocytic leukemia

    Moshe Oren; Sharath Chandra Arundkar (2015)
  • BREX is a novel phage resistance system widespread in microbial genomes

    Tamara Goldfarb; Hila Sberro; Eyal Weinstock; Ofir Cohen; Shany Doron; Yoav Charpak-Amikam; Shaked Afik; Gal Ofir; Rotem Sorek (2015)
  • Historic recollections: From polymers and proteins to autoimmunity and cancer.

    Michael Sela (2015)
  • PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.

    Shiri Gur Cohen; Tomer Itkin; Sagarika Chakrabarty; Claudine Graf; Orit Kollet; Aya Ludin; Karin Golan; Alexander Kalinkovich; Guy Ledergor; Eitan Wong; Elisabeth Niemeyer; Ziv Porat; Ayelet Erez; Irit Sagi; Charles T Esmon; Wolfram Ruf; Tsvee Lapidot (2015)
  • AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences

    GD Lapidoth; Dror Baran; GM Pszolla; Christoffer Norn; Assaf Alon; MD Tyka; SJ Fleishman (2015)
  • Cancer immunotherapy: More is (much) better

    Yosef Yarden; Michael Sela (2015)
  • ECM remodelling in IBD: innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation

    Elee Shimshoni; Doron Yablecovitch; Liran Baram; Iris Dotan; Irit Sagi (2015)
  • Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody

    Yael Udi; Moran Grossman; Inna Solomonov; Orly Dym; Haim Rozenberg; Vanessa Moreno; Philippe Cuniasse; Vincent Dive; Arroyo, Alicia Garcia Arroyo; Irit Sagi (2015)
  • Fine Tuning of a Type 1 Interferon Antagonist

    Victoria Urin; Doron Levin; N Sharma; Daniel Harari; Gideon Schreiber (2015)
  • The Human Otubain2-Ubiquitin Structure Provides Insights into the Cleavage Specificity of Poly-Ubiquitin-Linkages

    Mikael Altun; Thomas S. Walter; Holger B. Kramer; Patrick Herr; Alexander Iphoefer; Johan Bostrom; Yael David; Alia Komsany; Nicola Ternette; Ami Navon; David I. Stuart; Jingshan Ren; Benedikt M. Kessler (2015)
  • Combined Crystal Structure of a Type I Cohesin MUTATION AND AFFINITY BINDING STUDIES REVEAL STRUCTURAL DETERMINANTS OF COHESIN-DOCKERIN SPECIFICITIES

    K Cameron; JY Weinstein; Olga Zhivin; P Bule; SJ Fleishman; VD Alves; HJ Gilbert; LMA Ferreira; CMGA Fontes; Ed Bayer; S Najmudin (2015)
  • Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.

    Zohar Eyal; Donna Matzov; Miri Krupkin; Itai Wekselman; Susanne Paukner; Ella Zimmerman; Haim Rozenberg; Anat Bashan; Ada Yonath (2015)
  • Muscle composition is regulated by a Lox-TGF beta feedback loop

    Liora Kutchuk; Anu Laitala; Sharon Soueid-Bomgarten; Pessia Shentzer; Ann-Helen Rosendahl; Shelly Eilot; Moran Grossman; Irit Sagi; Raija Sormunen; Johanna Myllyharju; Joni M. Maki; Peleg Hasson (2015)
  • EGF induces microRNAs that target suppressors of cell migration: miR-15b targets MTSS1 in breast cancer

    Merav Kedmi; Chetrit, Nir Ben Chetrit; Cindy Koerner; Maicol Mancini; Noa Bossel Ben-Moshe; Mattia Lauriola; Sara Lavi; Francesca Biagioni; Silvia Carvalho; Hadas Cohen-Dvashi; Fernando Schmitt; Stefan Wiemann; Giovanni Blandino; Yosef Yarden (2015)
  • Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

    Chetrit, Nir Ben Chetrit; David Chetrit; Roslin Russell; Cindy Koerner; Maicol Mancini; Ali Abdul-Hai; Tomer Itkin; Silvia Carvalho; Hadas Cohen-Dvashi; Wolfgang J. Koestler; Kirti Shukla; Moshit Lindzen; Merav Kedmi; Mattia Lauriola; Ziv Shulman; Haim Barr; Dalia Seger; Daniela A. Ferraro; Fresia Pareja; Hava Gil-Henn; Ronen Alon; Fernanda Milanezi; Marc Symons; Hamo, Rotem Ben Hamo; Sol Efroni; Fernando Schmitt; Stefan Wiemann; Carlos Caldas; Marcelo Ehrlich; Yosef Yarden (2015)
  • Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age.

    Ziv Zwighaft; Rona Aviram; Moran Shalev; Noori, Liat Rousso Noori; Judith Kraut-Cohen; Marina Golik; Alexander Brandis; Hans Reinke; Asaph Aharoni; Chaim Kahana; Gad Asher (2015)
  • Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression

    Hadas Cohen-Dvashi; Chetrit, Nir Ben Chetrit; Roslin Russell; Silvia Carvalho; Mattia Lauriola; Sophia Nisani; Maicol Mancini; Nishanth Nataraj; Merav Kedmi; Lee Roth; Wolfgang Koestler; Amit Zeisel; Assif Yitzhaky; Jacques Zylberg; Gabi Tarcic; Raya Eilam; Yoav Wigelman; Rainer Will; Sara Lavi; Ziv Porat; Stefan Wiemann; Sara Ricardo; Fernando Schmitt; Carlos Caldas; Yosef Yarden (2015)
  • p53 orchestrates between normal differentiation and cancer

    Noa Rivlin; Gabriela Koifman; Varda Rotter (2015)
  • ErbB3-ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas

    Claudia Capparelli; Sheera Rosenbaum; Lisa D. Berman-Booty; Amel Salhi; Nadege Gaborit; Tingting Zhan; Inna Chervoneva; Jason Roszik; Scott E. Woodman; Michael A. Davies; Yulius Y. Setiady; Iman Osman; Yosef Yarden; Andrew E. Aplin (2015)
  • CRISPR adaptation biases explain preference for acquisition of foreign DNA

    Asaf Levy; Moran G. Goren; Ido Yosef; Oren Auster; Miriam Manor; Gil Amitai; Rotem Edgar; Udi Qimron; Rotem Sorek (2015)
  • Enhanced in Vivo Efficacy of a Type I Interferon Superagonist with Extended Plasma Half-life in a Mouse Model of Multiple Sclerosis

    Daniel Harari; Nadine Kuhn; Renne Abramovich; Keren Sasson; Alla L. Zozulya; Paul Smith; Martin Schlapschy; Rina Aharoni; Mario Koester; Raya Eilam; Arne Skerra; Gideon Schreiber (2014)
  • EGF receptor family: twisting targets for improved cancer therapies

    Antony W. Burgess; Yoav I. Henis; Nancy E. Hynes; Thomas Jovin; Alexander Levitzki; Ronit Pinkas-Kramarski; Yosef Yarden (2014)
  • CD84 is a survival receptor for CLL cells

    I. Binsky-Ehrenreich; Ayelet Marom; M. C. Sobotta; L. Shvidel; A. Berrebi; I. Hazan-Halevy; S. Kay; Anna Aloshin; Irit Sagi; D. M. Goldenberg; L. Leng; R. Bucala; Y. Herishanu; M. Haran; Idit Shachar (2014)
  • Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation

    Noa Rivlin; Shir Katz; Maayan Doody; Michal Sheffer; Stav Horesh; Alina Molchadsky; Gabriela Koifman; Yoav Shetzer; Naomi Goldfinger; Varda Rotter; Tamar Geiger (2014)
  • p53: The barrier to cancer stem cell formation

    Ronit Aloni-Grinstein; Yoav Shetzer; Tom Kaufman; Varda Rotter (2014)
  • Downregulation of microRNAs 145-3p and 145-5p Is a Long-term Predictor of Postmenopausal Breast Cancer Risk: The ORDET Prospective Study

    Paola Muti; Andrea Sacconi; Ahmed Hossain; Sara Donzelli; Moshe, Noa Bossel Ben Moshe; Federica Ganci; Sabina Sieri; Vittorio Krogh; Franco Berrino; Francesca Biagioni; Sabrina Strano; Joseph Beyene; Yosef Yarden; Giovanni Blandino (2014)
  • Fur Is the Master Regulator of the Extraintestinal Pathogenic Escherichia coli Response to Serum

    Sagi Huja; Yaara Oren; Dvora Biran; Susann Meyer; Ulrich Dobrindt; Joerg Bernhard; Doerte Becher; Michael Hecker; Rotem Sorek; Eliora Z. Ron (2014)
  • Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ

    Hilla Solomon; Michal Sharon; Varda Rotter (2014)
  • Oligodendrogenesis and myelinogenesis during postnatal development effect of glatiramer acetate

    Renana From; Raya Eilam; Dekel D. Bar-Lev; Smadar Levin-Zaidman; Michael Tsoory; Patrizia LoPresti; Michael Sela; Ruth Arnon; Rina Aharoni (2014)
  • Recapitulation of non-small-cell lung carcinoma microenvironment in perfusion bioreactor cultures: the impact of hypoxia on tumour-stroma crosstalk

    VE Santo; M Estrada; S Veloso; MFQ Sousa; der Kuip, H Van der Kuip; Moshe Oren; ER Boghaert; PM Alves; C Brito (2014)
  • Tumor suppressor microRNAs: A novel non-coding alliance against cancer

    Giovanni Blandino; Francesco Fazi; Sara Donzelli; Merav Kedmi; Aldema Sas-Chen; Paola Muti; Sabrina Strano; Yosef Yarden (2014)
  • Mapping the diatom redox-sensitive proteome provides insight into response to nitrogen stress in the marine environment

    Shilo Rosenwasser; Creveld, Shiri Graff van Creveld; Daniella Schatz; Sergey Malitsky; Oren Tzfadia; Asaph Aharoni; Yishai Levin; Alexandra Gabashvili; Ester Feldmesser; Assaf Vardi (2014)
  • Ovarian Dendritic Cells Act as a Double-Edged Pro-Ovulatory and Anti-Inflammatory Sword

    Adva Cohen-Fredarow; Ari Tadmor; Tal Raz; Naama Meterani; Yoseph Addadi; Nava Nevo; Inna Solomonov; Irit Sagi; Gil Mor; Michal Neeman; Nava Dekel (2014)
  • Multifaceted Activities of Type I Interferon Are Revealed by a Receptor Antagonist

    Doron Levin; William M. Schneider; Hans-Heinrich Hoffmann; Ganit Yarden; Alberto Giovanni Busetto; Ohad Manor; Nanaocha Sharma; Charles M. Rice; Gideon Schreiber (2014)
  • Enzyme structure captures four cysteines aligned for disulfide relay

    Yair Gat; Alexandra Vardi-Kilshtain; Iris Grossman; Dan Thomas Major; Deborah Fass (2014)
  • Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment

    Mattia Lauriola; Yehoshua Enuka; Amit Zeisel; Gabriele D'Uva; Lee Roth; Michal Sharon-Sevilla; Moshit Lindzen; Kirti Sharma; Nava Nevo; Silvia Carvalho; Hadas Cohen-Dvashi; Merav Kedmi; Chetrit, Nir Ben Chetrit; Alon Chen; Rossella Solmi; Stefan Wiemann; Fernando Schmitt; Eytan Domany; Yosef Yarden (2014)
  • An O-methyltransferase modifies accumulation of methylated anthocyanins in seedlings of tomato

    Maria Victoria Gomez Roldan; Nikolay Outchkourov; Houwelingen, Adele van Houwelingen; Michiel Lammers; la Fuente, Irene Romero de la Fuente; Noa Ziklo; Asaph Aharoni; Robert D. Hall; Jules Beekwilder (2014)
  • The Eps1p Protein Disulfide Isomerase Conserves Classic Thioredoxin Superfamily Amino Acid Motifs but Not Their Functional Geometries

    Shai Biran; Yair Gat; Deborah Fass (2014)
  • ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A

    Erez Romi; Irena Gokhman; Eitan Wong; Niv Antonovsky; Andreas Ludwig; Irit Sagi; Paul Saftig; Marc Tessier-Lavigne; Avraham Yaron (2014)
  • Sequential capsule endoscopy of the small bowel for follow-up of patients with known Crohn's disease

    Eva Niv; Sigal Fishman; Helena Kachman; Ruth Arnon; Iris Dotan (2014)
  • RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38

    A. Weilbacher; M. Gutekunst; Moshe Oren; W. E. Aulitzky; der Kuip, H. van der Kuip (2014)
  • The paradigm of mutant p53-expressing cancer stem cells and drug resistance

    Yoav Shetzer; Hilla Solomon; Gabriela Koifman; Alina Molchadsky; Stav Horesh; Varda Rotter (2014)
  • Present and future breast cancer management-bench to bedside and back: a positioning paper of academia, regulatory authorities and pharmaceutical industry

    R. Bartsch; S. Frings; M. Marty; A. Awada; A. S. Berghoff; P. Conte; S. Dickin; H. Enzmann; M. Gnant; M. Hasmann; H. R. Hendriks; A. Llombart; C. Massacesi; Minckwitz, G. von Minckwitz; F. Penault-Llorca; M. Scaltriti; Yosef Yarden; H. Zwierzina; C. C. Zielinski (2014)
  • The mutant p53-cancer stem cells and drug resistance paradigm

    Varda Rotter (2014)
  • Parainflammation in cancer

    A Lasry; H Hamza; E Kadosh; E Elyada; Ariel Pribluda; K Alitalo; T Stiewe; Moshe Oren; E Pikarsky; Y Ben-Neriah (2014)
  • Sequestration of a two-component response regulator by a riboswitch-regulated noncoding RNA

    J. R. Mellin; Mikael Koutero; Daniel Dar; Marie-Anne Nahori; Rotem Sorek; Pascale Cossart (2014)
  • Steering tumor progression through the transcriptional response to growth factors and stroma

    Morris Feldman; Yosef Yarden (2014)
  • Parainflammation in cancer

    Audrey Lasry; Dvir Aran; Adar Zinger; Haya Hamza; Eliran Kadosh; Ela Elyada; Ariel Pribluda; Asaf Hellman; Moshe Oren; Eli Pikarsky; Yinon Ben-Neriah (2014)
  • Proffered Paper: Regulation of NF-kB, inflammation and cancer by the E3 ligase RNF20

    Ohad Tarcic; Moshe Oren (2014)
  • Enzymatic turnover of macromolecules generates long-lasting protein-water-coupled motions beyond reaction steady state

    Jessica Dielmann-Gessner; Moran Grossman; Valeria Conti Nibali; Benjamin Born; Inna Solomonov; Gregg B. Fields; Martina Havenith; Irit Sagi (2014)
  • The inflammatory cytokine TNF alpha cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells

    Tal Leibovich-Rivkin; Yulia Liubomirski; Tsipi Meshel; Anastasia Abashidze; Daphna Brisker; Hilla Solomon; Varda Rotter; Miguel Weil; Adit Ben-Baruch (2014)
  • SEEDSTICK is a Master Regulator of Development and Metabolism in the Arabidopsis Seed Coat

    Chiara Mizzotti; Ignacio Ezquer; Dario Paolo; Paloma Rueda-Romero; Rosalinda Fiorella Guerra; Raffaella Battaglia; Ilana Rogachev; Asaph Aharoni; Martin M. Kater; Elisabetta Caporali; Lucia Colombo (2014)
  • SSNMR of biosilica-entrapped enzymes permits an easy assessment of preservation of native conformation in atomic detail

    Marco Fragai; Claudio Luchinat; Tommaso Martelli; Enrico Ravera; Irit Sagi; Inna Solomonov; Yael Udi (2014)
  • Science Signaling Podcast: 27 May 2014

    Gideon Schreiber; Annalisa M. VanHook (2014)
  • Pla2g16 phospholipase mediates gain-of-function activities of mutant p53

    Shunbin Xiong; Huolin Tu; Madhusudhan Kollareddy; Vinod Pant; Qin Li; Yun Zhang; James G. Jackson; Young-Ah Suh; Ana C. Elizondo-Fraire; Peirong Yang; Gilda Chau; Mehrnoosh Tashakori; Amanda R. Wasylishen; Zhenlin Ju; Hilla Solomon; Varda Rotter; Bin Liu; Adel K. El-Naggar; Lawrence A. Donehower; Luis Alfonso Martinez; Guillermina Lozano (2014)
  • Small molecules: from structural diversity to signalling and regulatory roles

    Dorothea Tholl; Asaph Aharoni (2014)
  • Complex in vitro and in vivo prostate cancer models for the PREDECT consortium

    S Vidic; N Esser; Hoogt, R de Hoogt; I Verberne; I Kogan-Sakin; Yan Stein; Varda Rotter; M Barbier; Y Chong; SD Breucker; K Smans; M Akerfelt; M Nees; P King; I Hickson; Weerden, W van Weerden; R Graeser (2014)
  • Caught in the cross fire: p53 in inflammation

    Tomer Cooks; CC Harris; Moshe Oren (2014)
  • In and out: an analysis of epibiotic vs periplasmic bacterial predators

    Z. Pasternak; M. Njagi; Yaron Shani; R. Chanyi; O. Rotem; M. N. Lurie-Weinberger; S. Koval; Shmuel Pietrokovski; U. Gophna; E. Jurkevitch (2014)
  • Affinity- and Specificity-Enhancing Mutations Are Frequent in Multispecific Interactions between TIMP2 and MMPs

    Oz Sharabi; Jason Shirian; Moran Grossman; Mario Lebendiker; Irit Sagi; Julia Shifman (2014)
  • Enhanced in vivo efficacy of a long-life type I Interferon superagonist in a mouse model of multiple sclerosis

    Daniel Harari; Nadine Kallweit; Renne Abramovich; Keren Sasson; Alla Zozulya; Paul Smith; Martin Schlapschy; Rina Aharoni; Mario Koester; Raya Eliam; Arne Skerra; Gideon Schreiber (2014)
  • Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

    M Shingai; OK Donau; RJ Plishka; A Buckler-White; JR Mascola; GJ Nabel; MC Nason; D Montefiori; B Moldt; P Poignard; Ron Diskin; PJ Bjorkman; MA Eckhaus; F Klein; H Mouquet; JCC Lorenzi; A Gazumyan; DR Burton; MC Nussenzweig; MA Martin; Y Nishimura (2014)
  • Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

    Netanya G. Sandler; Steven E. Bosinger; Jacob D. Estes; Richard T. R. Zhu; Gregory K. Tharp; Eli Boritz; Doron Levin; Sathi Wijeyesinghe; Krystelle Nganou Makamdop; Prete, Gregory Q. del Prete; Brenna J. Hill; J. Katherina Timmer; Emma Reiss; Ganit Yarden; Samuel Darko; Eduardo Contijoch; John Paul Todd; Guido Silvestri; Martha Nason; Robert B., Jr. Norgren; Brandon F. Keele; Srinivas Rao; Jerome A. Langer; Jeffrey D. Lifson; Gideon Schreiber; Daniel C. Douek (2014)
  • Proffered Paper: miRNA induces escape from NK cell-mediated cytotoxicity and resistance towards apoptosis in breast cancer

    C Breunig; M Kublbeck; M Miller; D Antonelli; C Wirth; N Erdem; Yosef Yarden; A Cerwenka; S Wiemann (2014)
  • Small molecules that interact with RNA: riboswitch-based gene control and its involvement in metabolic regulation in plants and algae

    Samuel E. Bocobza; Asaph Aharoni (2014)
  • Rewiring Host Lipid Metabolism by Large Viruses Determines the Fate of Emiliania huxleyi, a Bloom-Forming Alga in the Ocean

    Shilo Rosenwasser; Michaela A. Mausz; Daniella Schatz; Uri Sheyn; Sergey Malitsky; Asaph Aharoni; Eyal Weinstock; Oren Tzfadia; Shifra Ben-Dor; Ester Feldmesser; Georg Pohnert; Assaf Vardi (2014)
  • Pathways and therapeutic targets in melanoma

    Emma Shtivelman; Michael A. Davies; Patrick Hwu; James Yang; Michal Lotem; Moshe Oren; Keith T. Flaherty; David E. Fisher (2014)
  • The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

    Tai Kiuchi; Elena Ortiz-Zapater; James Monypenny; Daniel R. Matthews; Lan K. Nguyen; Jody Barbeau; Oana Coban; Katherine Lawler; Brian Burford; Daniel J. Rolfe; Rinaldis, Emanuele de Rinaldis; Dimitra Dafou; Michael A. Simpson; Natalie Woodman; Sarah Pinder; Cheryl E. Gillett; Viviane Devauges; Simon P. Poland; Gilbert Fruhwirth; Pierfrancesco Marra; Ykelien L. Boersma; Andreas Plueckthun; William J. Gullick; Yosef Yarden; George Santis; Martyn Winn; Boris N. Kholodenko; Marisa L. Martin-Fernandez; Peter Parker; Andrew Tutt; Simon M. Ameer-Beg; Tony Ng (2014)
  • Enhanced in vivo efficacy using a novel long-life type I interferon variant in a mouse model of multiple sclerosis

    Daniel Harari; Nadine Kallweit; Renne Abramovich; Keren Sasson; Alla Zozulya; Paul Smith; Martin Schlapschy; Rina Aharoni; Mario Koester; Raya Eliam; Arne Skerra; Gideon Schreiber (2014)
  • Unraveling Hidden Regulatory Sites in Structurally Homologous Metalloproteases

    Yael Udi; Marco Fragai; Moran Grossman; Simon Mitternacht; Rina Arad-Yellin; Vito Calderone; Maxime Melikian; Mirco Toccafondi; Igor N. Berezovsky; Claudio Luchinat; Irit Sagi (2013)
  • Inhibition of triple-negative breast cancer models by combinations of antibodies to EGFR

    Daniela A. Ferraro; Nadege Gaborit; Ruth Maron; Hades Cohen-Dvashi; Ziv Porat; Fresia Pareja; Sara Lavi; Moshit Lindzen; Chetrit, Nir Ben Chetrit; Michael Sela; Yosef Yarden (2013)
  • CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea

    Rotem Sorek; C. Martin Lawrence; Blake Wiedenheft (2013)
  • Overcoming HIV pathways for escape using rationally-designed anti-HIV antibodies

    Ron Diskin; D. Noah Sather; Paola M. Marcovecchio; Terri Lee; Anthony P., Jr. West; Han Gao; Florian Klein; Joshua Horwitz; Michael S. Seaman; Leonidas Stamatatos; Michel C. Nussenzweig; Pamela J. Bjorkman (2013)
  • Age dependent course of EAE in Aire(-/-) mice

    Rina Aharoni; Revital Aricha; Raya Eilam; Ido From; Keren Mizrahi; Ruth Arnon; Miriam C. Souroujon; Sara Fuchs (2013)
  • Mutant p53 Prolongs NF-kappa B Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

    Tomer Cooks; Ioannis S. Pateras; Ohad Tarcic; Hilla Solomon; Aaron J. Schetter; Sylvia Wilder; Guillermina Lozano; Eli Pikarsky; Tim Forshew; Nitzan Rozenfeld; Noam Harpaz; Steven Itzkowitz; Curtis C. Harris; Varda Rotter; Vassilis G. Gorgoulis; Moshe Oren (2013)
  • Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles

    Neta Regev-Rudzki; Danny W. Wilson; Teresa G. Carvalho; Xavier Sisquella; Bradley M. Coleman; Melanie Rug; Dejan Bursac; Fiona Angrisano; Michelle Gee; Andrew F. Hill; Jake Baum; Alan F. Cowman (2013)
  • Antibiotics at the Ribosomal Exit Tunnel-Selected Structural Aspects

    Ella Zimmerman; Anat Bashan; Ada Yonath (2013)
  • p63 Attenuates Epithelial to Mesenchymal Potential in an Experimental Prostate Cell Model

    Jan Roger Olsen; Anne Margrete Oyan; Kari Rostad; Margrete R. Hellem; Jie Liu; Lisha Li; David R. Micklem; Hallvard Haugen; James B. Lorens; Varda Rotter; Xi-Song Ke; Biaoyang Lin; Karl-Henning Kalland (2013)
  • The challenges of cellular compartmentalization in plant metabolic engineering

    Uwe Heinig; Michael Gutensohn; Natalia Dudareva; Asaph Aharoni (2013)
  • Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies

    Ron Diskin; Florian Klein; Joshua A. Horwitz; Ariel Halper-Stromberg; D. Noah Sather; Paola M. Marcovecchio; Terri Lee; Anthony P., Jr. West; Han Gao; Michael S. Seaman; Leonidas Stamatatos; Michel C. Nussenzweig; Pamela J. Bjorkman (2013)
  • Endocytosis and Cancer

    Ira Mellman; Yosef Yarden (2013)
  • Beta-Catenin/HuR Post-Transcriptional Machinery Governs Cancer Stem Cell Features in Response to Hypoxia

    Gabriele D'Uva; Sara Bertoni; Mattia Lauriola; Carolis, Sabrina De Carolis; Annalisa Pacilli; Laura D'Anello; Donatella Santini; Mario Taffurelli; Claudio Ceccarelli; Yosef Yarden; Lorenzo Montanaro; Massimiliano Bonafe; Gianluca Storci (2013)
  • Structural Basis for HIV-1 gp120 Recognition by a Germ-line Version of a Broadly Neutralizing Antibody

    L. Scharf; A. P. West; J. F. Scheid; M. C. Nussenzweig; P. J. Bjorkman; Ron Diskin (2013)
  • High-resolution metabolic mapping of cell types in plant roots

    Arieh Moussaieff; Ilana Rogachev; Leonid Brodsky; Sergey Malitsky; Ted W. Toal; Heather Belcher; Merav Yativ; Siobhan M. Brady; Philip N. Benfey; Asaph Aharoni (2013)
  • Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning

    Hila Sberro; Azita Leavitt; Ruth Kiro; Eugene Koh; Yoav Peleg; Udi Qimron; Rotem Sorek (2013)
  • Magnetic resonance imaging characterization of different experimental autoimmune encephalomyelitis models and the therapeutic effect of glatiramer acetate

    Rina Aharoni; Efrat Sasson; Tamar Blumenfeld-Katzir; Raya Eilam; Michael Sela; Yaniv Assaf; Ruth Arnon (2013)
  • A Global Transcriptional Switch between the Attack and Growth Forms of Bdellovibrio bacteriovorus

    Iris Karunker; Or Rotem; Mally Dori-Bachash; Edouard Jurkevitch; Rotem Sorek (2013)
  • A Secreted Disulfide Catalyst Controls Extracellular Matrix Composition and Function

    Tal Ilani; Assaf Alon; Iris Grossman; Ben Horowitz; Elena Kartvelishvily; Sidney Cohen; Deborah Fass (2013)
  • Computational evaluation of cellular metabolic costs successfully predicts genes whose expression is deleterious

    Allon Wagner; Raphy Zarecki; Leah Reshef; Camelia Gochev; Rotem Sorek; Uri Gophna; Eytan Ruppin (2013)
  • Type I interferon signaling is suppressed in Experimental Autoimmune Encephalomyelitis (EAE): Implications for multiple sclerosis

    Daniel Harari; Renne Abramovich; Nadine Kallweit; Sandrine Pouly; Alla Zozulya-Weidenfeller; Paul Smith; Martin Schlapschy; Mario Koester; Hansjoerg Hauser; Arne Skerra; Gideon Schreiber (2013)
  • Tomato fruits expressing a bacterial feedback-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway possess enhanced levels of multiple specialized metabolites and upgraded aroma

    Vered Tzin; Ilana Rogachev; Sagit Meir; Zvi, Michal Moyal Ben Zvi; Tania Masci; Alexander Vainstein; Asaph Aharoni; Gad Galili (2013)
  • 'Cancer associated fibroblasts' - more than meets the eye

    Shalom Madar; Ido Goldstein; Varda Rotter (2013)
  • An Inhibitory Antibody Blocks the First Step in the Dithiol/Disulfide Relay Mechanism of the Enzyme QSOX1

    Iris Grossman; Assaf Alon; Tal Ilani; Deborah Fass (2013)
  • Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts- Secreted Interferon Beta

    Shalom Madar; Einav Harel; Ido Goldstein; Yan Stein; Ira Kogan-Sakin; Iris Kamer; Hilla Solomon; Elya Dekel; Perry Tal; Naomi Goldfinger; Gilgi Friedlander; Varda Rotter (2013)
  • Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs

    Sam Hoot; Andrew T. McGuire; Kristen W. Cohen; Roland K. Strong; Lars Hangartner; Florian Klein; Ron Diskin; Johannes F. Scheid; D. Noah Sather; Dennis R. Burton; Leonidas Stamatatos (2013)
  • Diversification of Quiescin sulfhydryl oxidase in a preserved framework for redox relay

    Waisberg, Keren Limor Waisberg; Shifra Ben-Dor; Deborah Fass (2013)
  • Differential Translation Tunes Uneven Production of Operon-Encoded Proteins

    Tessa E. F. Quax; Yuri I. Wolf; Jasper J. Koehorst; Omri Wurtzel; der Oost, Richard van der Oost; Wenqi Ran; Fabian Blombach; Kira S. Makarova; Stan J. J. Brouns; Anthony C. Forster; E. Gerhart H. Wagner; Rotem Sorek; Eugene V. Koonin; der Oost, John van der Oost (2013)
  • Holding a grudge: Persisting anti-phage CRISPR immunity in multiple human gut microbiomes

    Eran Mick; Adi Stern; Rotem Sorek (2013)
  • Inhibition of pancreatic carcinoma by homo- and heterocombinations of antibodies against EGF-receptor and its kin HER2/ErbB-2

    Ruth Maron; Bilha Schechter; Maicol Mancini; Georg Mahlknecht; Yosef Yarden; Michael Sela (2013)
  • Now at the Met: Fine Art of Reversible Sulfoxidation

    Tal Ilani; Deborah Fass (2013)
  • Oriented Covalent Immobilization of Antibodies for Measurement of Intermolecular Binding Forces between Zipper-Like Contact Surfaces of Split Inteins

    Mirco Sorci; Bareket Dassa; Hongwei Liu; Gaurav Anand; Arnit K. Dutta; Shmuel Pietrokovski; Marlene Belfort; Georges Belfort (2013)
  • Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53

    Ido Goldstein; Noa Rivlin; Or-yam Shoshana; Osnat Ezra; Shalom Madar; Naomi Goldfinger; Varda Rotter (2013)
  • CD84 is a survival receptor for chronic lymphocytic leukemia cells

    Ayelet Marom; Inbal Binsky-Ehrenreich; Mirko Sobotta; Lev Shvidel; Alain Berrebi; Inbal Hazan-Halevy; Sigi Kay; Anna Aloshin; Irit Sagi; David Goldenberg; Lin Leng; Richard Bucala; Yair Herishanu; Michal Haran; Idit Shachar (2013)
  • A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

    Ariel Pribluda; Ela Elyada; Zoltan Wiener; Haya Hamza; Robert E. Goldstein; Moshe Biton; Ido Burstain; Yael Morgenstern; Guy Brachya; Hana Billauer; Sharon Biton; Irit Snir-Alkalay; Domagoj Vucic; Katharina Schlereth; Marco Mernberger; Thorsten Stiewe; Moshe Oren; Kari Alitalo; Eli Pikarsky (2013)
  • Basic cancer research is essential for the success of personalised medicine

    Yosef Yarden; Carlos Caldes (2013)
  • The locus of microRNA-10b A critical target for breast cancer insurgence and dissemination

    Francesca Biagioni; Noa Bossel Ben-Moshe; Giulia Fontemaggi; Yosef Yarden; Eytan Domany; Giovanni Blandino (2013)
  • p53 Counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition

    Ran Brosh; Y. Assia-Alroy; Alina Molchadsky; Chamutal Bornstein; Elya Dekel; Shalom Madar; Yoav Shetzer; Noa Rivlin; Naomi Goldfinger; Rachel Sarig; Varda Rotter (2013)
  • The excludon: a new concept in bacterial antisense RNA-mediated gene regulation

    Nina Sesto; Omri Wurtzel; Cristel Archambaud; Rotem Sorek; Pascale Cossart (2013)
  • By their genes ye shall know them: genomic signatures of predatory bacteria

    Zohar Pasternak; Shmuel Pietrokovski; Or Rotem; Uri Gophna; Mor N. Lurie-Weinberger; Edouard Jurkevitch (2013)
  • Targeting ErbB-1 and ErbB-4 in irradiated head and neck cancer: Results of in vitro and in vivo studies

    Itay Barnea; Sasha Haif; Rom Keshet; Vicky Karaush; Shahar Lev-Ari; Avi Khafif; Alexander Shtabsky; Yosef Yarden; Akiva Vexler; Yosef, Rami Ben Yosef (2013)
  • Formation of protein complexes in crowded environments - From in vitro to in vivo

    Yael Phillip; Gideon Schreiber (2013)
  • Emerging themes in the computational design of novel enzymes and protein-protein interfaces

    Sagar D. Khare; Sarel J. Fleishman (2013)
  • Computational Design of a Protein-Based Enzyme Inhibitor

    Erik Procko; Rickard Hedman; Keith Hamilton; Jayaraman Seetharaman; Sarel J. Fleishman; Min Su; James Aramini; Gregory Kornhaber; John F. Hunt; Liang Tong; Gaetano T. Montelione; David Baker (2013)
  • Transcriptome-Wide Mapping of 5-methylcytidine RNA Modifications in Bacteria, Archaea, and Yeast Reveals m(5)C within Archaeal mRNAs

    Sarit Edelheit; Schraga Schwartz; Maxwell R. Mumbach; Omri Wurtzel; Rotem Sorek (2013)
  • Aptamer to ErbB-2/HER2 enhances degradation of the target and inhibits tumorigenic growth

    Georg Mahlknecht; Ruth Maron; Maicol Mancini; Bilha Schechter; Michael Sela; Yosef Yarden (2013)
  • Transcriptional Control by NF-kappa B: Elongation in Focus

    Gil Diamant; Rivka Dikstein (2013)
  • Orchestration of Thiamin Biosynthesis and Central Metabolism by Combined Action of the Thiamin Pyrophosphate Riboswitch and the Circadian Clock in Arabidopsis

    Samuel E. Bocobza; Sergey Malitsky; Wagner L. Araujo; Adriano Nunes-Nesi; Sagit Meir; Michal Shapira; Alisdair R. Fernie; Asaph Aharoni (2013)
  • In Vitro Microbiotic Fermentation Causes an Extensive Metabolite Turnover of Rye Bran Phytochemicals

    Kati Hanhineva; Anna-Marja Aura; Ilana Rogachev; Sanni Matero; Thomas Skov; Asaph Aharoni; Kaisa Poutanen; Hannu Mykkanen (2012)
  • The dynamic disulphide relay of quiescin sulphydryl oxidase

    Assaf Alon; Iris Grossman; Yair Gat; Vamsi K. Kodali; Frank DiMaio; Tevie Mehlman; Gilad Haran; David Baker; Colin Thorpe; Deborah Fass (2012)
  • RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation

    Gilad Fuchs; Efrat Shema; Rita Vesterman; Eran Kotler; Zohar Wolchinsky; Sylvia Wilder; Lior Golomb; Ariel Pribluda; Feng Zhang; Mahmood Haj-Yahya; Ester Feldmesser; Ashraf Brik; Xiaochun Yu; Jacob Hanna; Daniel Aberdam; Eytan Domany; Moshe Oren (2012)
  • Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling

    C-R Pradeep; W. J. Koestler; Mattia Lauriola; R. Z. Granit; F. Zhang; J. Jacob-Hirsch; G. Rechavi; H. B. Nair; B. T. Hennessy; A. M. Gonzalez-Angulo; R. R. Tekmal; I. Ben-Porath; G. B. Mills; Eytan Domany; Yosef Yarden (2012)
  • Comparative transcriptomics of pathogenic and non-pathogenic Listeria species

    Omri Wurtzel; Nina Sesto; J. R. Mellin; Iris Karunker; Sarit Edelheit; Christophe Becavin; Cristel Archambaud; Pascale Cossart; Rotem Sorek (2012)
  • The Direction of Protein Entry into the Proteasome Determines the Variety of Products and Depends on the Force Needed to Unfold Its Two Termini

    Dikla Berko; Shira Tabachnick-Cherny; Dalit Shental-Bechor; Paolo Cascio; Silvia Mioletti; Yaakov Levy; Arie Admon; Tamar Ziv; Boaz Tirosh; Alfred L. Goldberg; Ami Navon (2012)
  • Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis

    Rina Aharoni; Ravit Saada; Raya Eilam; Liat Hayardeny; Michael Sela; Ruth Arnon (2012)
  • Asymmetric adaptation to indolic and aliphatic glucosinolates in the B and Q sibling species of Bemisia tabaci (Hemiptera: Aleyrodidae)

    Michal Elbaz; E. Halon; O. Malka; Sergey Malitsky; E. Blum; Asaph Aharoni; S. Morin (2012)
  • Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

    Nett A. Sela-Passwell; Raghavendra Kikkeri; Orly Dym; Haim Rozenberg; Raanan Margalit; Rina Arad-Yellin; Miriam Eisenstein; Ori Brenner; Tsipi Shoham; Tamar Danon; Abraham Shanzer; Irit Sagi (2012)
  • Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues

    Gilad Landan; Netta Mendelson Cohen; Zohar Mukamel; Amir Bar; Alina Molchadsky; Ran Brosh; Shirley Horn-Saban; Daniela Amann Zalcenstein; Naomi Goldfinger; Adi Zundelevich; Einav Nil Gal-Yam; Varda Rotter; Amos Tanay (2012)
  • Evolutionary perspective on distinct features of GSK-3 isozymes

    M. Shapira; L. Avrahami; L. Tsaadon-Alon; Shmuel Pietrokovski; A. Barnea; H. Eldar-Finkelman (2012)
  • HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

    Florian Klein; Ariel Halper-Stromberg; Joshua A. Horwitz; Henning Gruell; Johannes F. Scheid; Stylianos Bournazos; Hugo Mouquet; Linda A. Spatz; Ron Diskin; Alexander Abadir; Trinity Zang; Marcus Dorner; Eva Billerbeck; Rachael N. Labitt; Christian Gaebler; Paola M. Marcovecchio; Reha-Baris Incesu; Thomas R. Eisenreich; Paul D. Bieniasz; Michael S. Seaman; Pamela J. Bjorkman; Jeffrey V. Ravetch; Alexander Ploss; Michel C. Nussenzweig (2012)
  • Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

    Hilla Solomon; Yosef Buganim; Ira Kogan-Sakin; Leslie Pomeraniec; Yael Assia; Shalom Madar; Ido Goldstein; Ran Brosh; Eyal Kalo; Tsevi Beatus; Naomi Goldfinger; Varda Rotter (2012)
  • Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions

    C-R Pradeep; Amit Zeisel; W. J. Koestler; Mattia Lauriola; J. Jacob-Hirsch; B. Haibe-Kains; N. Amariglio; Chetrit, Nir Ben Chetrit; Anna Maria Emde; Inna Solomonov; G. Neufeld; M. Piccart; Irit Sagi; C. Sotiriou; G. Rechavi; Eytan Domany; C. Desmedt; Yosef Yarden (2012)
  • EGFR AND HER2: PROTOTYPES OF FUTURE CANCER THERAPY

    Yosef Yarden (2012)
  • A vast collection of microbial genes that are toxic to bacteria

    Aya Kimelman; Asaf Levy; Hila Sberro; Shahar Kidron; Azita Leavitt; Gil Amitai; Deborah R. Yoder-Himes; Omri Wurtzel; Yiwen Zhu; Edward M. Rubin; Rotem Sorek (2012)
  • Crosstalk of cancer cells and cancer associated fibroblasts in the p53 response to Cisplatin in intact tissues from NSCLC specimen

    J. O. Schmid; M. Dong; S. Haubeiss; G. Friedel; Moshe Oren; T. Muerdter; W. E. Aulitzky; der Kuip, H. van der Kuip (2012)
  • UPLC-MS-based metabolite analysis in tomato

    Ilana Rogachev; Asaph Aharoni (2012)
  • Diverse Functions of IGF/Insulin Signaling in Malignant and Noncancerous Prostate Cells: Proliferation in Cancer Cells and Differentiation in Noncancerous Cells

    Isabel Heidegger; Philipp Ofer; Wolfgang Doppler; Varda Rotter; Helmut Klocker; Petra Massoner (2012)
  • The ERBB network: at last, cancer therapy meets systems biology

    Yosef Yarden; Gur Pines (2012)
  • Exploring ORFan Domains in Giant Viruses: Structure of Mimivirus Sulfhydryl Oxidase R596

    Motti Hakim; Daria Ezerina; Assaf Alon; Ohad Vonshak; Deborah Fass (2012)
  • RNA-seq analysis of small RNPs in Trypanosoma brucei reveals a rich repertoire of non-coding RNAs

    Shulamit Michaeli; Tirza Doniger; Sachin Kumar Gupta; Omri Wurtzel; Mali Romano; Damian Visnovezky; Rotem Sorek; Ron Unger; Elisabetta Ullu (2012)
  • Cancer Cells Cue the p53 Response of Cancer-Associated Fibroblasts to Cisplatin

    Jens O. Schmid; Meng Dong; Silke Haubeiss; Godehard Friedel; Sabine Bode; Andreas Grabner; German Ott; Thomas E. Muerdter; Moshe Oren; Walter E. Aulitzky; der Kuip, Heiko van der Kuip (2012)
  • A Crossroad of microRNAs and Immediate Early Genes (IEGs) Encoding Oncogenic Transcription Factors in Breast Cancer

    Aldema Sas-Chen; Roi Avraham; Yosef Yarden (2012)
  • miR-10b*, a master inhibitor of the cell cycle, is down-regulated in human breast tumours

    Francesca Biagioni; Noa Bossel Ben-Moshe; Giulia Fontemaggi; Valeria Canu; Federica Mori; Barbara Antoniani; Benedetto, Anna Di Benedetto; Raffaela Santoro; Sabrina Germoni; Angelis, Fernanda De Angelis; Anna Cambria; Roi Avraham; Giuseppe Grasso; Sabrina Strano; Paola Muti; Marcella Mottolese; Yosef Yarden; Eytan Domany; Giovanni Blandino (2012)
  • Formation of Protein-Complexes in crowded environments: From in vitro to in vivo

    Gideon Schreiber; Yael Phillip (2012)
  • Co-mapping studies of QTLs for fruit acidity and candidate genes of organic acid metabolism and proton transport in sweet melon (Cucumis melo L.)

    Shimon Cohen; G. Tzuri; R. Harel-Beja; Maxim Itkin; V. Portnoy; U. Sa'ar; Sima Lev; L. Yeselson; M. Petrikov; Ilana Rogachev; Asaph Aharoni; R. Ophir; Y. Tadmor; E. Lewinsohn; Y. Burger; N. Katzir; A. A. Schaffer (2012)
  • Reconstruction of Arabidopsis metabolic network models accounting for subcellular compartmentalization and tissue-specificity

    Shira Mintz-Oron; Sagit Meir; Sergey Malitsky; Eytan Ruppin; Asaph Aharoni; Tomer Shlomi (2012)
  • Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression

    F. Pareja; D. A. Ferraro; C. Rubin; Hadas Cohen-Dvashi; F. Zhang; S. Aulmann; Chetrit, Nir Ben Chetrit; Gur Pines; R. Navon; N. Crosetto; Wolfgang Koestler; Silvia Carvalho; Sara Lavi; F. Schmitt; I. Dikic; Z. Yakhini; P. Sinn; G. B. Mills; Yosef Yarden (2012)
  • GROWTH FACTORS IN BREAST CANCER

    Yosef Yarden (2012)
  • Identification of CTCF as a master regulator of the clustered protocadherin genes

    Mashiach, Michal Golan Mashiach; Moshe Grunspan; Rafi Emmanuel; Liron Gibbs-Bar; Rivka Dikstein; Ehud Shapiro (2012)
  • Cancer research, a field on the verge of a paradigm shift?

    Ido Goldstein; Shalom Madar; Varda Rotter (2012)
  • Mutant p53(R273H) attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species

    Eyal Kalo; Ira Kogan-Sakin; Hilla Solomon; Elad Bar-Nathan; Moshe Shay; Yoav Shetzer; Elya Dekel; Naomi Goldfinger; Yossi Buganim; Perry Stambolsky; Ido Goldstein; Shalom Madar; Varda Rotter (2012)
  • CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome

    Adi Stern; Eran Mick; Itay Tirosh; Or Sagy; Rotem Sorek (2012)
  • Inflammatory control of colorectal cancer progression

    Y. Ben-Neriah; Ariel Pribluda; E. Elyada; I. Snir-Alkalay; E. Pikarsky; Moshe Oren; Z. Wiener; K. Alitalo (2012)
  • Expression of a bacterial feedback-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway in Arabidopsis elucidates potential metabolic bottlenecks between primary and secondary metabolism

    Vered Tzin; Sergey Malitsky; Zvi, Michal Moyal Ben Zvi; Mohamed Bedair; Lloyd Sumner; Asaph Aharoni; Gad Galili (2012)
  • Network and Systems Biology in Cancer

    Yosef Yarden (2012)
  • Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation

    Jacob Piehler; Christoph Thomas; K. Christopher Garcia; Gideon Schreiber (2012)
  • A recombinant decoy comprising EGFR and ErbB-4 inhibits tumor growth and metastasis

    Moshit Lindzen; Silvia Carvalho; A. Starr; Chetrit, Nir Ben Chetrit; C-R Pradeep; W. J. Koestler; Aharon Rabinkov; Sara Lavi; S. S. Bacus; Yosef Yarden (2012)
  • Zn2+-A beta 40 Complexes Form Metastable Quasi-spherical Oligomers That Are Cytotoxic to Cultured Hippocampal Neurons

    Inna Solomonov; Eduard Korkotian; Benjamin Born; Yishay (Isai) Feldman; Arkady Bitler; Farid Rahimi; Huiyuan Li; Gal Bitan; Irit Sagi (2012)
  • Fruit cuticular and agronomic characteristics of a lecer6 mutant of tomato

    David L. Ehret; Brenda Frey; Tom Helmer; Asaph Aharoni; Zhonghua Wang; Reinhard Jetter (2012)
  • Phylogenetics and enzymology of plant quiescin sulfhydryl oxidase

    Waisberg, Keren Limor Waisberg; Assaf Alon; Tevie Mehlman; Deborah Fass (2012)
  • DSIF Restricts NF-kappa B Signaling by Coordinating Elongation with mRNA Processing of Negative Feedback Genes

    Gil Diamant; Liat Amir-Zilberstein; Yuki Yamaguchi; Hiroshi Handa; Rivka Dikstein (2012)
  • DePICTing p53 Activation: A New Nucleolar Link to Cancer

    Lior Golomb; Moshe Oren (2011)
  • TMPRSS2/ERG Promotes Epithelial to Mesenchymal Transition through the ZEB1/ZEB2 Axis in a Prostate Cancer Model

    Orit Leshem; Shalom Madar; Ira Kogan-Sakin; Iris Kamer; Ido Goldstein; Ran Brosh; Yehudit Cohen; Jasmine Jacob-Hirsch; Marcelo Ehrlich; Shmuel Ben-Sasson; Naomi Goldfinger; Ron Loewenthal; Ephraim Gazit; Varda Rotter; Raanan Berger (2011)
  • Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression

    Yosef Buganim; Shalom Madar; Yoach Rais; Leslie Pomeraniec; Einav Harel; Hilla Solomon; Eyal Kalo; Ido Goldstein; Ran Brosh; Ora Haimov; Camila Avivi; Sylvie Polak-Charcon; Naomi Goldfinger; Iris Barshack; Varda Rotter (2011)
  • Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model

    Xi-song Ke; Wen-cheng Li; Randi Hovland; Yi Qu; Run-hui Liu; Emmet McCormack; Frits Thorsen; Jan Roger Olsen; Anders Molven; Ira Kogan-Sakin; Varda Rotter; Lars A. Akslen; Anne Margrete Oyan; Karl-Henning Kalland (2011)
  • Overview of Vaccine Strategies

    Ruth Arnon (2011)
  • Distinct pathological patterns in relapsing-remitting and chronic models of experimental autoimmune enchephalomyelitis and the neuroprotective effect of glatiramer acetate

    Rina Aharoni; Anya Vainshtein; Ariel Stock; Raya Eilam; Renana From; Vera Shinder; Ruth Arnon (2011)
  • Mutant p53 gain of function is interwoven into the hallmarks of cancer

    Hilla Solomon; Shalom Madar; Varda Rotter (2011)
  • Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit

    Matthew J. Belousoff; Tal Shapira; Anat Bashan; Ella Zimmerman; Haim Rozenberg; Kenji Arakawa; Haruyasu Kinashi; Ada Yonath (2011)
  • The Biological Framework: Translational Research from Bench to Clinic

    Yosef Yarden (2011)
  • Carcinogen-Induced Hepatic Tumors in KLF6+/- Mice Recapitulate Aggressive Human Hepatocellular Carcinoma Associated with p53 Pathway Deregulation

    Mirko Tarocchi; Rebekka Hannivoort; Yujin Hoshida; Ursula E. Lee; Diana Vetter; Goutham Narla; Augusto Villanueva; Moshe Oren; Josep M. Llovet; Scott L. Friedman (2011)
  • Bacterial genomes: from regulatory complexity to engineering

    Rotem Sorek; Luis Serrano (2011)
  • Convergence of Logic of Cellular Regulation in Different Premalignant Cells by an Information Theoretic Approach

    Nataly Kravchenko-Balasha; F. Remacle; Ayelet Gross; Varda Rotter; Alexander Levitzki; R. D. Levine (2011)
  • Structure of a Baculovirus Sulfhydryl Oxidase, a Highly Divergent Member of the Erv Flavoenzyme Family

    Motti Hakim; Amitai Mandelbaum; Deborah Fass (2011)
  • The Glial Scar-Monocyte Interplay: A Pivotal Resolution Phase in Spinal Cord Repair

    Ravid Shechter; Catarina Raposo; Anat London; Irit Sagi; Michal Schwartz (2011)
  • The EGFR/ErbB Family in Breast Cancer: From Signalling to Therapy

    Wolfgang J. Koestler; Yosef Yarden (2011)
  • Stochastic Receptor Expression Determines Cell Fate upon Interferon Treatment

    Doron Levin; Daniel Harari; Gideon Schreiber (2011)
  • Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

    Ido Goldstein; V. Marcel; M. Olivier; Moshe Oren; Varda Rotter; P. Hainaut (2011)
  • Beneficial Effect of Glatiramer Acetate Treatment on Syndecan-1 Expression in Dextran Sodium Sulfate Colitis

    Doron Yablecovitch; Simon, Maytal Shabat Simon; Rina Aharoni; Raya Eilam; Ori Brenner; Ruth Arnon (2011)
  • E3 Ligases Determine Ubiquitination Site and Conjugate Type by Enforcing Specificity on E2 Enzymes

    Yael David; Nicola Ternette; Mariola J. Edelmann; Tamar Ziv; Batya Gayer; Rotem Sertchook; Yakir Dadon; Benedikt M. Kessler; Ami Navon (2011)
  • Binding and activity of all human alpha interferon subtypes

    Thomas B. Lavoie; Eyal Kalie; Sara Crisafulli-Cabatu; Renne Abramovich; Gina DiGioia; Karlene Moolchan; Sidney Pestka; Gideon Schreiber (2011)
  • DISTINCT PATHOLOGICAL PATTERNS IN RELAPSING-REMITTING AND CHRONIC MODELS OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS AND THE NEUROPROTECTIVE EFFECT OF GLATIRAMER ACETATE

    Rina Aharoni; R. Eilam; Ariel Stock; Anna Vainshtein; Renana From; Ruth Arnon (2011)
  • New opportunities in drug design of metalloproteinase inhibitors: combination between structure-function experimental approaches and systems biology

    Netta Sela-Passwell; Alla Trahtenherts; Achim Krueger; Irit Sagi (2011)
  • Probing Conformational Variations at the ATPase Site of the RNA Helicase DbpA by High-Field Electron-Nuclear Double Resonance Spectroscopy

    Ilia Kaminker; Anastasiya Sushenko; Alexey Potapov; Shirley Daube; Barak Akabayov; Irit Sagi; Daniella Goldfarb (2011)
  • Activity, specificity and structure of I-Bth0305I: a representative of a new homing endonuclease family

    Gregory K. Taylor; Daniel F. Heiter; Shmuel Pietrokovski; Barry L. Stoddard (2011)
  • Peptides and Polypeptides as Immunomodulators and Their Consequential Therapeutic Effect in Multiple Sclerosis and Other Autoimmune Diseases

    Ruth Arnon; Michael Sela; Rina Aharoni (2011)
  • Qualitative Characterization of Benzoxazinoid Derivatives in Whole Grain Rye and Wheat by LC-MS Metabolite Profiling

    Kati Hanhineva; Ilana Rogachev; Anna-Marja Aura; Asaph Aharoni; Kaisa Poutanen; Hannu Mykkanen (2011)
  • Metabolic engineering of the plant primary-secondary metabolism interface

    Asaph Aharoni; Gad Galili (2011)
  • Two Phases of Mitogenic Signaling Unveil Roles for p53 and EGR1 in Elimination of Inconsistent Growth Signals

    Yaara Zwang; Aldema Sas-Chen; Yotam Drier; Tal Shay; Roi Avraham; Mattia Lauriola; Efrat Shema; Nili, Efrat Lidor Nili; Jasmine Jacob-Hirsch; Ninette Amariglio; Yiling Lu; Gordon B. Mills; Gideon Rechavi; Moshe Oren; Eytan Domany; Yosef Yarden (2011)
  • Distinct Molecular Regulation of Glycogen Synthase Kinase-3 alpha Isozyme Controlled by Its N-terminal Region FUNCTIONAL ROLE IN CALCIUM/CALPAIN SIGNALING

    Inbar Azoulay-Alfaguter; Yakey Yaffe; Avital Licht-Murava; Malgorzata Urbanska; Jacek Jaworski; Shmuel Pietrokovski; Koret Hirschberg; Hagit Eldar-Finkelman (2011)
  • The phage-host arms race: Shaping the evolution of microbes

    Adi Stern; Rotem Sorek (2011)
  • Selective loss of glycogen synthase kinase-3 alpha in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

    Lina Tsaadon Alon; Shmuel Pietrokovski; Shay Barkan; Limor Avrahami; Oksana Kaidanovich-Beilin; James R. Woodgett; Anat Barnea; Hagit Eldar-Finkelman (2011)
  • Protein binding specificity versus promiscuity

    Gideon Schreiber; Amy E. Keating (2011)
  • Glatiramer acetate (GA, Copolymer-1) an hypothetical treatment option for Rett syndrome

    B. Ben-Zeev; Rina Aharoni; A. Nissenkorn; Ruth Arnon (2011)
  • The synchrotron radiation and the ribosome

    Haim Rozenberg; Ada Yonath (2011)
  • DISTINCT PATHOLOGICAL PATTERNS IN RELAPSING-REMITTING AND CHRONIC MODELS OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS AND THE BENEFICIAL EFFECT OF GLATIRAMER ACETATE

    Rina Aharoni; R. Eilam; Ariel Stock; Anna Vainshtein; Ruth Arnon (2011)
  • Genomic island variability facilitates Prochlorococcus-virus coexistence

    Sarit Avrani; Omri Wurtzel; Itai Sharon; Rotem Sorek; Debbie Lindell (2011)
  • Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer

    Yuval Tabach; Ira Kogan-Sakin; Yosef Buganim; Hilla Solomon; Naomi Goldfinger; Randi Hovland; Xi-Song Ke; Anne M. Oyan; Karl-H. Kalland; Varda Rotter; Eytan Domany (2011)
  • Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site

    Moran Grossman; Benjamin Born; Matthias Heyden; Dmitry Tworowski; Gregg B. Fields; Irit Sagi; Martina Havenith (2011)
  • Unleash the wild type: Restoration of p53 suppressive activity in skin cancer

    Shalom Madar; Perry Stambolsky; Varda Rotter (2011)
  • Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

    Christoph Thomas; Ignacio Moraga; Doron Levin; Peter O. Krutzik; Yulia Podoplelova; Angelica Trejo; Choongho Lee; Ganit Yarden; Susan E. Vleck; Jeffrey S. Glenn; Garry P. Nolan; Jacob Piehler; Gideon Schreiber; K. Christopher Garcia (2011)
  • Combining epitope-distinct antibodies to HER2: cooperative inhibitory effects on invasive growth

    Anna Maria Emde; C-R Pradeep; D. A. Ferraro; Chetrit, Nir Ben Chetrit; M. Sela; B. Ribba; Zvi Kam; Yosef Yarden (2011)
  • p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes

    Ariel Rinon; Alina Molchadsky; Elisha Nathan; Gili Yovel; Varda Rotter; Rachel Sarig; Eldad Tzahor (2011)
  • Generation and characterization of peptide mimotopes specific for anti ErbB-2 monoclonal antibodies

    Esther J. Witsch; Georg Mahlknecht; Jean Wakim; Rotem Sertchook; Erez Bublil; Yosef Yarden; Michael Sela (2011)
  • Simultaneous Inhibition of Estrogen Receptor and the HER2 Pathway in Breast Cancer: Effects of HER2 Abundance

    Anna Emde; Georg Mahlknecht; Kerstin Maslak; Benjamin Ribba; Michael Sela; Kurt Possinger; Yosef Yarden (2011)
  • Mutant p53 Gain-of-Function in Cancer

    Moshe Oren; Varda Rotter (2010)
  • The ribosome as drug target: lessons from 3D structures

    Anat Zaytzev-Bashan; Ella Zimmerman; Matthew Belousoff; Haim Rozenberg; Chen Davidovich; Itai Wekselman; Tal Shapira; Miri Krupkin; Ada Yonath (2010)
  • p53 is balancing development, differentiation and de-differentiation to assure cancer prevention

    Alina Molchadsky; Noa Rivlin; Ran Brosh; Varda Rotter; Rachel Sarig (2010)
  • Substrate Competitive GSK-3 Inhibitors - strategy and Implications

    Hagit Eldar-Finkelman; Avital Licht-Murava; Shmuel Pietrokovski; Miriam Eisenstein (2010)
  • Self-targeting by CRISPR: gene regulation or autoimmunity?

    Adi Stern; Leeat Keren; Omri Wurtzel; Gil Amitai; Rotem Sorek (2010)
  • Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53

    Perry Stambolsky; Yuval Tabach; Giulia Fontemaggi; Lilach Weisz; Revital Maor-Aloni; Zahava Sigfried; Idit Shiff; Ira Kogan; Moshe Shay; Eyal Kalo; Giovanni Blandino; Itamar Simon; Moshe Oren; Varda Rotter (2010)
  • Feedback control of receptor tyrosine kinases: multiple defects in cancer

    Yosef Yarden (2010)
  • Steps in reductive activation of the disulfide-generating enzyme Ero1p

    Nimrod Heldman; Ohad Vonshak; Carolyn S. Sevier; Elvira Vitu; Tevie Mehlman; Deborah Fass (2010)
  • Tailored cancer immunotherapy using combinations of chemotherapy and a mixture of antibodies against EGF-receptor ligands

    Moshit Lindzen; Sara Lavi; Orith Leitner; Yosef Yarden (2010)
  • The Rebirth of a Phoenix: Ovarian Cancers Are Addicted to ErbB-3

    Gordon B. Mills; Yosef Yarden (2010)
  • Cytokine-receptor interactions as drug targets

    Gideon Schreiber; Mark R. Walter (2010)
  • Polar Bears, Antibiotics, and the Evolving Ribosome (Nobel Lecture)

    Ada Yonath (2010)
  • Prokaryotic transcriptomics: a new view on regulation, physiology and pathogenicity

    Rotem Sorek; Pascale Cossart (2010)
  • A Novel Translocation Breakpoint within the BPTF Gene Is Associated with a Pre-Malignant Phenotype

    Yosef Buganim; Ido Goldstein; Doron Lipson; Michael Milyavsky; Sylvie Polak-Charcon; Corine Mardoukh; Hilla Solomon; Eyal Kalo; Shalom Madar; Ran Brosh; Marina Perelman; Roy Navon; Naomi Goldfinger; Iris Barshack; Zohar Yakhini; Varda Rotter (2010)
  • Repression of transposable-elements - a microRNA anti-cancer defense mechanism?

    Reut Shalgi; Yitzhak Pilpel; Moshe Oren (2010)
  • Direct Visualization of Protease Action on Collagen Triple Helical Structure

    Gabriel Rosenblum; den Steen, Philippe E. Van den Steen; Sidney Cohen; Arkady Bitler; David D. Brand; Ghislain Opdenakker; Irit Sagi (2010)
  • Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing-remitting or chronic EAE

    Rina Aharoni; Raya Eilam; Ariel Stock; Anya Vainshtein; Elias Shezen; Hilah Gal; Nir Friedman; Ruth Arnon (2010)
  • Structural and functional bases for allosteric control of MMP activities: Can it pave the path for selective inhibition?

    Netta Sela-Passwell; Gabriel Rosenblum; Tsipi Shoham; Irit Sagi (2010)
  • The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics

    Tamar Auerbach; Inbal Mermershtain; Chen Davidovich; Anat Bashan; Matthew Belousoff; Itai Wekselman; Ella Zimmerman; Liqun Xiong; Dorota Klepacki; Kenji Arakawa; Haruyasu Kinashi; Alexander S. Mankin; Ada Yonath (2010)
  • Oncogenic mutant forms of EGFR: Lessons in signal transduction and targets for cancer therapy

    Gur Pines; Wolfgang J. Koestler; Yosef Yarden (2010)
  • Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

    Jamie B. Spangler; Jason R. Neil; Sivan Abramovitch; Yosef Yarden; Forest M. White; Douglas A. Lauffenburger; K. Dane Wittrup (2010)
  • p53 Regulates the Ras Circuit to Inhibit the Expression of a Cancer-Related Gene Signature by Various Molecular Pathways

    Yosef Buganim; Hilla Solomon; Yoach Rais; Daria Kistner; Ido Nachmany; Mariana Brait; Shalom Madar; Ido Goldstein; Eyal Kalo; Nitzan Adam; Maya Gordin; Noa Rivlin; Ira Kogan; Ran Brosh; Galit Sefadia-Elad; Naomi Goldfinger; David Sidransky; Yoel Kloog; Varda Rotter (2010)
  • A Small Molecule Inhibitor of Endoplasmic Reticulum Oxidation 1 (ERO1) with Selectively Reversible Thiol Reactivity

    Jaime D. Blais; King-Tung Chin; Ester Zito; Yuhong Zhang; Nimrod Heldman; Heather P. Harding; Deborah Fass; Colin Thorpe; David Ron (2010)
  • Ancient machinery embedded in the contemporary ribosome

    Matthew J. Belousoff; Chen Davidovich; Ella Zimmerman; Yaron Caspi; Itai Wekselman; Lin Rozenszajn; Tal Shapira; Ofir Sade-Falk; Leena Taha; Anat Bashan; Manfred S. Weiss; Ada Yonath (2010)
  • Mutation Detection with Next-Generation Resequencing through a Mediator Genome

    Omri Wurtzel; Mally Dori-Bachash; Shmuel Pietrokovski; Edouard Jurkevitch; Rotem Sorek (2010)
  • TAF4b and Jun/Activating Protein-1 Collaborate to Regulate the Expression of Integrin alpha 6 and Cancer Cell Migration Properties

    Margarita Kalogeropoulou; Angeliki Voulgari; Vassiliki Kostourou; Raphael Sandaltzopoulos; Rivka Dikstein; Irwin Davidson; Laszlo Tora; Alexander Pintzas (2010)
  • The HER2 and EGFR alliance in cancer: defects in system control

    Yosef Yarden (2010)
  • p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation

    Ruth Scherz-Shouval; Hilla Weidberg; Chagay Gonen; Sylvia Wilder; Zvulun Elazar; Moshe Oren (2010)
  • An Orange Ripening Mutant Links Plastid NAD(P)H Dehydrogenase Complex Activity to Central and Specialized Metabolism during Tomato Fruit Maturation

    Shai Nashilevitz; Cathy Melamed-Bessudo; Yinon Izkovich; Ilana Rogachev; Sonia Osorio; Maxim Itkin; Avital Adato; Ilya Pankratov; Joseph Hirschberg; Alisdair R. Fernie; Shmuel Wolf; Bjoern Usadel; Avraham Levy; Dominique Rumeau; Asaph Aharoni (2010)
  • Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma

    Tobias Schilling; Astrid Kairat; Gerry Melino; Peter H. Krammer; Wolfgang Stremmel; Moshe Oren; Martina Mueller (2010)
  • Reduced interferon receptor levels resulting from either knockdown or prolonged Type I interferon treatment promote a shift in cellular responsiveness

    Daniel Harari; Doron Levin; Renana Abramovich; Gideon Schreiber (2010)
  • Involvement of stromal p53 in tumor-stroma interactions

    Jair Bar; Neta Moskovits; Moshe Oren (2010)
  • Roles for Growth Factors in Cancer Progression

    Esther Witsch; Michael Sela; Yosef Yarden (2010)
  • Hunting for Alternative Disulfide Bond Formation Pathways: Endoplasmic Reticulum Janitor Turns Professor and Teaches a Lesson

    Deborah Fass (2010)
  • QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains

    Assaf Alon; Erin J. Heckler; Colin Thorpe; Deborah Fass (2010)
  • Cytosolic Disulfide Bond Formation in Cells Infected with Large Nucleocytoplasmic DNA Viruses

    Motti Hakim; Deborah Fass (2010)
  • p53 and cancer: a complex affair

    Moshe Oren (2010)
  • Splicing of the Mycobacteriophage Bethlehem DnaB Intein IDENTIFICATION OF A NEW MECHANISTIC CLASS OF INTEINS THAT CONTAIN AN OBLIGATE BLOCK F NUCLEOPHILE

    Kazuo Tori; Bareket Dassa; Margaret A. Johnson; Maurice W. Southworth; Lear E. Brace; Yoshizumi Ishino; Shmuel Pietrokovski; Francine B. Perler (2010)
  • The E2 Ubiquitin-conjugating Enzymes Direct Polyubiquitination to Preferred Lysines

    Yael David; Tamar Ziv; Arie Admon; Ami Navon (2010)
  • Transcriptional control of the proliferation cluster by the tumor suppressor p53

    Ran Brosh; Varda Rotter (2010)
  • p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

    Ran Brosh; Rachel Sarig; Natan, Elad Bar Natan; Alina Molchadsky; Shalom Madar; Chamutal Bornstein; Yosef Buganim; Tirosh Shapira; Naomi Goldfinger; Ralf Paus; Varda Rotter (2010)
  • The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function

    Moran Grossman; Dmitry Tworowski; Orly Dym; Meng-Huee Lee; Yaakov Levy; Gillian Murphy; Irit Sagi (2010)
  • The Biological Framework: Translational Research from Bench to Clinic

    Yosef Yarden (2010)
  • A single-base resolution map of an archaeal transcriptome

    Omri Wurtzel; Rajat Sapra; Feng Chen; Yiwen Zhu; Blake A. Simmons; Rotem Sorek (2010)
  • A comparison of the binding of Interferon alpha subtypes to isolated IFNAR1 and IFNAR2 with activity in antiviral and antiproliferative assays

    Thomas B. Lavoie; Renne Abramovich; Sara Crisafulli Cabatu; Gina DiGioia; Karlene Moolchan; Sidney Pestka; Gideon Schreiber (2010)