• Extracellular vesicles in parasite survival

    Ofir-Birin Y. & Regev-Rudzki N. (2019)
  • Inhibition of a pancreatic cancer model by cooperative pairs of clinically approved and experimental antibodies

    Maron R., Schechter B., Nataraj N. B., Ghosh S., Romaniello D., Marrocco I., Noronha A., Carvalho S., Yarden Y. & Sela M. (2019)
  • Widespread Utilization of Peptide Communication in Phages Infecting Soil and Pathogenic Bacteria

    Stokar-Avihail A., Tal N., Erez Z., Lopatina A. & Sorek R. (2019)
  • Novel Approaches for Extracellular Matrix Targeting in Disease Treatment

    Afratis N. A. & Sagi I. (2019)
  • Indole derivatives maintain the status quo between beneficial biofilms and their plant hosts

    Ganin H., Kemper N., Meir S., Rogachev I., Ely S., Massalha H., Mandabi A., Keren-Paz A., Shanzer A., Meijler M., Malitsky S., Aharoni A. & Kolodkin-Gal I. (2019)
  • Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor

    Shraga A., Olshvang E., Davidzohn N., Khoshkenar P., Germain N., Shurrush K., Carvalho S., Avram L., Albeck S., Unger T., Lefker B., Subramanyam C., Hudkins R. L., Mitchell A., Shulman Z., Kinoshita T. & London N. (2019)
  • Chance and pleiotropy dominate genetic diversity in complex bacterial environments

    Noda-García L., Davidi D., Korenblum E., Elazar A., Putintseva E., Aharoni A. & Tawfik D. S. (2019)
  • Tuberculosis's cargoman: bacteria load RNA into host extracellular vesicles

    Biton M., Abou Karam P. & Regev-Rudzki N. (2019)
  • Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient

    Averbuch D., Safadi R., Dar D., Wolf D., Cherniak M., Sorek R. & Amit S. (2019)
  • Variations in Core Packing of GP2 from Old World Mammarenaviruses in their Post-Fusion Conformations Affect Membrane-Fusion Efficiencies

    Shulman A., Katz M., Cohen-Dvashi H., Greenblatt H. M., Levy Y. & Diskin R. (2019)
  • The ADAM17 Protease Promotes Tobacco Smoke Carcinogen-induced Lung Tumourigenesis

    Saad M. I., McLeod L., Yu L., Ebi H., Ruwanpura S., Sagi I., Rose-John S. & Jenkins B. J. (2019)
  • A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation

    Nuta G. C., Gilad Y., Gershoni M., Sznajderman A., Schlesinger T., Bialik S., Eisenstein M., Pietrokovski S. & Kimchi A. (2019)
  • 3D mapping of native extracellular matrix reveals cellular responses to the microenvironment

    Lansky Z., Mutsafi Y., Houben L., Ilani T., Armony G., Wolf S. G. & Fass D. (2019)
  • ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

    Saad M. I., Alhayyani S., McLeod L., Yu L., Alanazi M., Deswaerte V., Tang K., Jarde T., Smith J. A., Prodanovic Z., Tate M. D., Balic J. J., Watkins D. N., Cain J. E., Bozinovski S., Algar E., Kohmoto T., Ebi H., Ferlin W., Garbers C., Ruwanpura S., Sagi I., Rose-John S. & Jenkins B. J. (2019)
  • Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses

    Demarta-Gatsi C., Rivkin A., Di Bartolo V., Peronet R., Ding S., Commere P., Guillonneau F., Bellalou J., Brule S., Abou Karam P., Cohen S. R., Lagache T., Janse C. J., Regev-Rudzki N. & Mecheri S. (2019)
  • Differential antibody-based immune response against isolated GP1 receptor-binding domains from Lassa and Junín viruses

    Borenstein-Katz A., Shulman A., Hamawi H., Leitner O. & Diskin R. (2019)
  • Collagen: Methods and protocols

    Sagi I. & Afratis N. (2019)
  • New insights into YAP/TAZ nucleo-cytoplasmic shuttling: new cancer therapeutic opportunities?

    Shreberk-Shaked M. & Oren M. (2019)
  • Erratum: Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes (vol 39, e00441-18, 2019)

    Sehrawat U., Koning F., Ashkenazi S., Stelzer G., Leshkowitz D. & Dikstein R. (2019)
  • Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes

    Sehrawat U., Koning F., Ashkenazi S., Stelzer G., Leshkowitz D. & Dikstein R. (2019)
  • Demystifying the extracellular matrix and its proteolytic remodeling in the brain: structural and functional insights

    Krishnaswamy V. R., Benbenishty A., Blinder P. & Sagi I. (2019)
  • Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer

    Hooda J., Novak M., Salomon M. P., Matsuba C., Ramos R. I., MacDuffie E., Song M., Hirsch M. S., Lester J., Parkash V., Karlan B. Y., Oren M., Hoon D. S. & Drapkin R. (2019)
  • Appropriate Thiamin Pyrophosphate Levels Are Required for Acclimation to Changes in Photoperiod

    Rosado-Souza L., Proost S., Moulin M., Bergmann S., Bocobza S. E., Aharoni A., Fitzpatrick T. B., Mutwil M., Fernie A. R. & Obata T. (2019)
  • Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers

    Solomon H., Dinowitz N., Pateras I. S., Cooks T., Shetzer Y., Molchadsky A., Charni M., Rabani S., Koifman G., Tarcic O., Porat Z., Kogan-Sakin I., Goldfinger N., Oren M., Harris C. C., Gorgoulis V. G. & Rotter V. (2018)
  • Short-chain dehydrogenase/reductase governs steroidal specialized metabolites structural diversity and toxicity in the genus Solanum

    Sonawane P. D., Heinig U., Panda S., Gilboa N. S., Yona M., Kumar S. P., Alkan N., Unger T., Bocobza S., Pliner M., Malitsky S., Tkachev M., Meir S., Rogachev I. & Aharoni A. (2018)
  • Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication

    Nganou-Makamdop K., Billingsley J. M., Yaffe Z., O'Connor G., Tharp G. K., Ransier A., Laboune F., Matus-Nicodemos R., Lerner A., Gharu L., Robertson J. M., Ford M. L., Schlapschy M., Kuhn N., Lensch A., Lifson J., Nason M., Skerra A., Schreiber G., Bosinger S. E. & Douek D. C. (2018)
  • Astrocyte disruption of neurovascular communication is linked to cortical damage in an animal model of multiple sclerosis

    Eilam R., Segal M., Malach R., Sela M., Arnon R. & Aharoni R. (2018)
  • Structural basis for receptor recognition by Lujo virus

    Cohen-Dvashi H., Kilimnik I. & Diskin R. (2018)
  • Viruses cooperate to defeat bacteria

    Bernheim A. & Sorek R. (2018)
  • DISARM is a widespread bacterial defence system with broad anti-phage activities

    Ofir G., Melamed S., Sberro H., Mukamel Z., Silverman S., Yaakov G., Doron S. & Sorek R. (2018)
  • WRKY1 acts as a key component improving resistance against Alternaria solani in wild tomato, Solanum arcanum Peralta

    Shinde B. A., Dholakia B. B., Hussain K., Aharoni A., Giri A. P. & Kamble A. C. (2018)
  • Automated Design of Efficient and Functionally Diverse Enzyme Repertoires

    Khersonsky O., Lipsh R., Avizemer Z., Ashani Y., Goldsmith M., Leader H., Dym O., Rogotner S., Trudeau D. L., Prilusky J., Amengual-Rigo P., Guallar V., Tawfik D. S. & Fleishman S. J. (2018)
  • Highly active enzymes by automated combinatorial backbone assembly and sequence design

    Lapidoth G., Khersonsky O., Lipsh R., Dym O., Albeck S., Rogotner S. & Fleishman S. J. (2018)
  • The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery

    Afratis N. A., Klepfish M., Karamanos N. K. & Sagi I. (2018)
  • Mining Plants for Bacterial Quorum Sensing Modulators

    David S., Mandabi A., Uzi S., Aharoni A. & Meijler M. M. (2018)
  • Bacterial Noncoding RNAs Excised from within Protein-Coding Transcripts

    Dar D. & Sorek R. (2018)
  • Phagocyte-extracellular matrix crosstalk empowers tumor development and dissemination

    Varol C. & Sagi I. (2018)
  • Extensive reshaping of bacterial operons by programmed mRNA decay

    Dar D. & Sorek R. (2018)
  • Bacterial virulence against an oceanic bloom-forming phytoplankter is mediated by algal DMSP

    Barak-Gavish N., Frada M. J., Ku C., Lee P. A., DiTullio G. R., Malitsky S., Aharoni A., Green S. J., Rotkopf R., Kartvelishvily E., Sheyn U., Schatz D. & Vardi A. (2018)
  • A Combination of Approved Antibodies Overcomes Resistance of Lung Cancer to Osimertinib by Blocking Bypass Pathways

    Romaniello D., Mazzeo L., Mancini M., Marrocco I., Noronha A., Kreitman M., Srivastava S., Ghosh S., Lindzen M., Salame T. M., Onn A., Bar J. & Yarden Y. (2018)
  • A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation

    Kotler E., Shani O., Goldfeld G., Lotan-Pompan M., Tarcic O., Gershoni A., Hopf T. A., Marks D. S., Oren M. & Segal E. (2018)
  • Live cyanobacteria produce photocurrent and hydrogen using both the respiratory and photosynthetic systems

    Saper G., Kallmann D., Conzuelo F., Zhao F., Tóth T. N., Liveanu V., Meir S., Szymanski J., Aharoni A., Schuhmann W., Rothschild A., Schuster G. & Adir N. (2018)
  • LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state

    Furth N., Pateras I. S., Rotkopf R., Vlachou V., Rivkin I., Schmitt I., Bakaev D., Gershoni A., Ainbinder E., Leshkowitz D., Johnson R. L., Gorgoulis V. G., Oren M. & Aylon Y. (2018)
  • High-resolution RNA 3 '-ends mapping of bacterial Rho-dependent transcripts

    Dar D. & Sorek R. (2018)
  • Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models

    Minzel W., Venkatachalam A., Fink A., Hung E., Brachya G., Burstain I., Shaham M., Rivlin A., Omer I., Zinger A., Elias S., Winter E., Erdman P. E., Sullivan R. W., Fung L., Mercurio F., Li D., Vacca J., Kaushansky N., Shlush L., Oren M., Levine R., Pikarsky E., Snir-Alkalay I. & Ben-Neriah Y. (2018)
  • Emerging insights into the role of matrix metalloproteases as therapeutic targets in fibrosis

    Afratis N. A., Selman M., Pardo A. & Sagi I. (2018)
  • An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors

    Mancini M., Gal H., Gaborit N., Mazzeo L., Romaniello D., Salame T. M., Lindzen M., Mahlknecht G., Enuka Y., Burton D. G. A., Roth L., Noronha A., Marrocco I., Adreka D., Altstadter R. E., Bousquet E., Downward J., Maraver A., Krizhanovsky V. & Yarden Y. (2018)
  • Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features

    Arandkar S., Furth N., Elisha Y., Belugali Nataraj N., van der Kuip H., Yarden Y., Aulitzky W., Ulitsky I., Geiger B. & Oren M. (2018)
  • Malaria Parasites Distribute Subversive Messages across Enemy Lines

    Rivkin A., Ben-Hur S. & Regev-Rudzki N. (2017)
  • Pathogen-derived extracellular vesicles coordinate social behaviour and host manipulation

    Ofir Birin B. Y., Heidenreich M. & Regev-Rudzki N. (2017)
  • let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery

    Spolverini A., Fuchs G., Bublik D. R. & Oren M. (2017)
  • Analysis of the S. cerevisiae family of deubiquitinating enzymes reveals robustness over specificity

    Berko D., David Y. & Navon A. (2017)
  • The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis

    Miettinen K., Pollier J., Buyst D., Arendt P., Csuk R., Sommerwerk S., Moses T., Mertens J., Sonawane P. D., Pauwels L., Aharoni A., Martins J., Nelson D. R. & Goossens A. (2017)
  • Live imaging of root-bacteria interactions in a microfluidics setup

    Massalha H., Korenblum E., Malitsky S., Shapiro O. H. & Aharoni A. (2017)
  • The polyketide synthase OsPKS2 is essential for pollen exine and Ubisch body patterning in rice

    Zhu X., Yu J., Shi J., Tohge T., Fernie A. R., Meir S., Aharoni A., Xu D., Zhang D. & Liang W. (2017)
  • Metabolic Flexibility Underpins Growth Capabilities of the Fastest Growing Alga

    Treves H., Murik O., Kedem I., Eisenstadt D., Meir S., Rogachev I., Szymanski J., Keren N., Orf I., Tiburcio A. F., Alcazar R., Aharoni A., Kopka J. & Kaplan A. (2017)
  • Communication between viruses guides lysis-lysogeny decisions

    Erez Z., Steinberger-Levy I., Shamir M., Doron S., Stokar Avihail A. A., Peleg Y., Melamed S., Leavitt A., Savidor A., Albeck S., Amitai G. & Sorek R. (2017)
  • Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation

    Ziarek J. J., Kleist A. B., London N., Raveh B., Montpas N., Bonneterre J., St-Onge G., DiCosmo-Ponticello C. J., Koplinski C. A., Roy I., Stephens B., Thelen S., Veldkamp C. T., Coffman F. D., Cohen M. C., Dwinell M. B., Thelen M., Peterson F. C., Heveker N. & Volkman B. F. (2017)
  • The short and the long: non-coding RNAs and growth factors in cancer progression

    Sas-Chen A., Srivastava S. & Yarden Y. (2017)
  • Effective cell-free drug screening protocol for protein-protein interaction

    Ashkenazi S., Plotnikov A., Bahat A. & Dikstein R. (2017)
  • p53 on the crossroad between regeneration and cancer

    Charni M., Aloni-Grinstein R., Molchadsky A. & Rotter V. (2017)
  • Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers

    Goldsmith M., Aggarwal N., Ashani Y., Jubran H., Greisen P. J., Ovchinnikov S., Leader H., Baker D., Sussman J., Goldenzweig A., Fleishman S. J. & Tawfik D. (2017)
  • Immune deficiency augments the prevalence of p53 loss of heterozygosity in spontaneous tumors but not bi-directional loss of heterozygosity in bone marrow progenitors

    Shetzer Y., Napchan Y., Kaufman T., Molchadsky A., Tal P., Goldfinger N. & Rotter V. (2017)
  • Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs

    Yogev O., Henderson S., Hayes M. J., Marelli S. S., Ofir Birin B. Y., Regev-Rudzki N., Herrero J. & Enver T. (2017)
  • Diversity of antiviral defense strategies of bacteria at the population level

    Lopatina A., Millman A., Abram E., Silverman S., Melamed S., Leavitt A. & Sorek R. (2017)
  • Next generation matrix metalloproteinase inhibitors - Novel strategies bring new prospects

    Levin M., Udi Y., Solomonov I. & Sagi I. (2017)
  • Phosphatidylserine externalization, "necroptotic bodies" release, and phagocytosis during necroptosis

    Zargarian S., Shlomovitz I., Erlich Z., Hourizadeh A., Ofir Birin B. Y., Croker B. A., Regev-Rudzki N., Edry-Botzer L. & Gerlic M. (2017)
  • A Bright Future for Antibiotics?

    Matzov D., Bashan A. & Yonath A. (2017)
  • Structural Basis for Receptor Selectivity by the Whitewater Arroyo Mammarenavirus

    Shimon A., Shani O. & Diskin R. (2017)
  • Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival

    Bublik D. R., Bursac S., Sheffer M., Orsolic I., Shalit T., Tarcic O., Kotler E., Mouhadeb O., Hoffman Y., Fuchs G., Levin Y., Volarevic S. & Oren M. (2017)
  • The extracellular matrix protein agrin promotes heart regeneration in mice

    Bassat E., Mutlak Y. E., Genzelinakh A., Shadrin I. Y., Umansky K., Yifa O., Kain D., Rajchman D., Leach J., Bassat D. R., Udi Y., Sarig R., Sagi I., Martin J. F., Bursac N., Cohen S. & Tzahor E. (2017)
  • The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus

    Matzov D., Aibara S., Basu A., Zimmerman E., Bashan A., Yap M. F., Amunts A. & Yonath A. E. (2017)
  • From mice to men: astrocyte morphology is confined by functional boundaries in the mammalian cortex

    Eilam R., Aharoni R., Arnon R. & Malach R. (2017)
  • The landscape of sex-differential transcriptome and its consequent selection in human adults

    Gershoni M. & Pietrokovski S. (2017)
  • Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus

    Matzov D., Eyal Z., Benhamou R. I., Shalev-Benami M., Halfon Y., Krupkin M., Zimmerman E., Rozenberg H., Bashan A., Fridman M. & Yonath A. (2017)
  • Increased potency of a bi-specific TL1A-ADAM17 (TACE) inhibitor by cell surface targeting

    Weizman T., Levin I., Zaretsky M., Sagi I. & Aharoni A. (2017)
  • Repression of CYSTATHIONINE gamma-SYNTHASE in Seeds Recruits the S-Methylmethionine Cycle

    Cohen H., Hacham Y., Panizel I., Rogachev I., Aharoni A. & Amir R. (2017)
  • One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen

    Campeotto I., Goldenzweig A., Davey J., Barfod L., Marshall J. M., Silk S. E., Wright K. E., Draper S. J., Higgins M. K. & Fleishman S. J. (2017)
  • The PhytoClust tool for metabolic gene clusters discovery in plant genomes

    Topfer N., Fuchs L. & Aharoni A. (2017)
  • Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome

    Belousoff M. J., Eyal Z., Radjainia M., Ahmed T., Bamert R. S., Matzov D., Bashan A., Zimmerman E., Mishra S., Cameron D., Elmlund H., Peleg A. Y., Bhushan S., Lithgow T. & Yonath A. (2017)
  • Identification and Characterization of Differentially-Regulated Type IVb Pilin Genes Necessary for Predation in Obligate Bacterial Predators

    Avidan O., Petrenko M., Becker R., Beck S., Linscheid M., Pietrokovski S. & Jurkevitch E. (2017)
  • Regulation of antibiotic-resistance by non-coding RNAs in bacteria

    Dar D. & Sorek R. (2017)
  • Quantifying enzyme activity in living cells

    Zotter A., Baeuerle F., Dey D., Kiss V. & Schreiber G. (2017)
  • Dynamic metabolic reprogramming of steroidal glycol-alkaloid and phenylpropanoid biosynthesis may impart early blight resistance in wild tomato (Solanum arcanum Peralta)

    Shinde B. A., Dholakia B. B., Hussain K., Panda S., Meir S., Rogachev I., Aharoni A., Giri A. P. & Kamble A. C. (2017)
  • Pancreatic cancer ascites xenograft-an expeditious model mirroring advanced therapeutic resistant disease

    Golan T., Stossel C., Schvimer M., Atias D., Halperin S., Buzhor E., Raitses Gurevich G. M., Cohen K., Pri-Chen S., Wilson J., Denroche R. E., Lungu I., Bartlett J. M. S., Mbabaali F., Yarden Y., Nataraj N. B., Gallinger S. & Berger R. (2017)
  • Optimality and sub-optimality in a bacterial growth law

    Towbin B. D., Korem Y., Bren A., Doron S., Sorek R. & Alon U. (2017)
  • The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel

    Wekselman I., Zimmerman E., Davidovich C., Belousoff M., Matzov D., Krupkin M., Rozenberg H., Bashan A., Friedlander G., Kjeldgaard J., Ingmer H., Lindahl L., Zengel J. M. & Yonath A. (2017)
  • Identification and classification of the malaria parasite blood developmental stages, using imaging flow cytometry

    Dekel E., Rivkin A., Heidenreich M. K., Nadav Y., Ofir Birin B. Y., Porat Z. & Regev-Rudzki N. (2017)
  • Improved antibody-based ricin neutralization by affinity maturation is correlated with slower off-rate values

    Rosenfeld R., Alcalay R., Mechaly A., Lapidoth G., Epstein E., Kronman C., Fleishman S. J. & Mazor O. (2017)
  • Matrix metalloproteinases: The sculptors of chronic cutaneous wounds: The sculptors of chronic cutaneous wounds

    Krishnaswamy V. R., Mintz D. & Sagi I. (2017)
  • Computational prediction of regulatory, premature transcription termination in bacteria

    Millman A., Dar D., Shamir M. & Sorek R. (2017)
  • Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses

    Israeli H., Cohen-Dvashi H., Shulman A., Shimon A. & Diskin R. (2017)
  • Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

    Sisquella X., Ofir-Birin Y., Pimentel M. A., Cheng L., Abou Karam P., Sampaio N. G., Penington J. S., Connolly D., Giladi T., Scicluna B. J., Sharples R. A., Waltmann A., Avni D., Schwartz E., Schofield L., Porat Z., Hansen D. S., Papenfuss A. T., Eriksson E. M., Gerlic M., Hill A. F., Bowie A. G. & Regev-Rudzki N. (2017)
  • Small molecules below-ground: the role of specialized metabolites in the rhizosphere

    Massalha H., Korenblum E., Tholl D. & Aharoni A. (2017)
  • Direct determination of enzyme kinetic parameters from single reactions using a new progress curve analysis tool

    Baeuerle F., Zotter A. & Schreiber G. (2017)
  • RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer

    Tarcic O., Granit R. Z., Pateras I. S., Masury H., Maly B., Zwang Y., Yarden Y., Gorgoulis V. G., Pikarsky E., Ben-Porath I. & Oren M. (2017)
  • CRISPR-Cas adaptation: insights into the mechanism of action.

    Amitai G. & Sorek R. (2016)
  • Role of LAMP1 Binding and pH Sensing by the Spike Complex of Lassa Virus

    Cohen-Dvashi H., Israeli H., Shani O., Katz A. & Diskin R. (2016)
  • LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer.

    Sas-Chen A., Aure M. R., Leibovich L., Carvalho S., Enuka Y., Korner C., Polycarpou-Schwarz M., Lavi S., Nevo N., Kuznetsov Y., Yuan J., Azuaje F., Ulitsky I., Diederichs S., Wiemann S., Yakhini Z., Kristensen V. N., Borresen-Dale A. & Yarden Y. (2016)
  • The relationship between the nucleolus and cancer: Current evidence and emerging paradigms

    Orsolic I., Jurada D., Pullen N., Oren M., Eliopoulos A. G. & Volarevic S. (2016)
  • Tumor macrophages are pivotal constructors of tumor collagenous matrix

    Afik R., Zigmond E., Vugman M., Klepfish M., Shimshoni E., Pasmanik-Chor M., Shenoy A., Bassat E., Halpern Z., Geiger T., Sagi I. & Varol C. (2016)
  • The Hippo pathway, p53 and cholesterol.

    Aylon Y. & Oren M. (2016)
  • Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation

    Shetzer Y., Molchadsky A. & Rotter V. (2016)
  • Repeat Size Determination by Two Molecular Rulers in the Type I-E CRISPR Array

    Goren M. G., Doron S., Globus R., Amitai G., Sorek R. & Qimron U. (2016)
  • Mutational and network level mechanisms underlying resistance to anti-cancer kinase inhibitors

    Mancini M. & Yarden Y. (2016)
  • Interfering with the Dimerization of the ErbB Receptors by Transmembrane Domain-Derived Peptides Inhibits Tumorigenic Growth in Vitro and in Vivo

    Bublil E. M., Cohen T., Arnusch C. J., Peleg A., Pines G., Lavi S. & Yarden Y. (2016)
  • Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells

    Grespi F., Landre V., Molchadsky A., Di Daniele D. N., Marsella L. T., Melino G. & Rotter V. (2016)
  • The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.

    Aylon Y., Gershoni A., Rotkopf R., Biton I. E., Porat Z., Koh A. P., Sun X., Lee Y., Fiel M., Hoshida Y., Friedman S. L., Johnson R. L. & Oren M. (2016)
  • ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016

    Dittrich C., Kosty M., Jezdic S., Pyle D., Berardi R., Bergh J., El-Saghir N., Lotz J., Osterlund P., Pavlidis N., Purkalne G., Awada A., Banerjee S., Bhatia S., Bogaerts J., Buckner J., Cardoso F., Casali P., Chu E., Close J. L., Coiffier B., Connolly R., Coupland S., De Petris P. L., De Santis S. M., de Vries V. E. G. E., Dizon D. S., Duff J., Duska L. R., Eniu A., Ernstoff M., Felip E., Fey M. F., Gilbert J., Girard N., Glaudemans A. W. J. M., Gopalan P. K., Grothey A., Hahn S. M., Hanna D., Herold C., Herrstedt J., Homicsko K., Jones D. V. J., Jost L., Keilholz U., Khan S., Kiss A., Koehne C., Kunstfeld R., Lenz H., Lichtman S., Licitra L., Lion T., Litiere S., Liu L., Loehrer P. J., Markham M. J., Markman B., Mayerhoefer M., Meran J. G., Michielin O., Moser E. C., Mountzios G., Moynihan T., Nielsen T., Ohe Y., Oberg K., Palumbo A., Peccatori F. A., Pfeilstoecker M., Raut C., Remick S. C., Robson M., Rutkowski P., Salgado R., Schapira L., Schernhammer E., Schlumberger M., Schmoll H., Schnipper L., Sessa C., Shapiro C. L., Steele J., Sternberg C. N., Stiefel F., Strasser F., Stupp R., Sullivan R., Tabernero J., Travado L., Verheij M., Voest E., Vokes E., Von Roenn R. J., Weber J. S., Wildiers H. & Yarden Y. (2016)
  • Natural selection underlies apparent stress-induced mutagenesis in a bacteriophage infection model

    Yosef I., Edgar R., Levy A., Amitai G., Sorek R., Munitz A., Qimron U., Mueller B., Tarkowski P. & Weiss D. (2016)
  • ADAM17 substrate release in proximal tubule drives kidney fibrosis

    Kefaloyianni E., Muthu M. L., Kaeppler J., Sun X., Sabbisetti V., Chalaris A., Rose-John S., Wong E., Sagi I., Waikar S. S., Rennke H., Humphreys B. D., Bonventre J. V. & Herrlich A. (2016)
  • Tumor cell invasion can be blocked by modulators of collagen fibril alignment that control assembly of the extracellular matrix.

    Grossman M., Ben Chetrit C. N., Zhuravlev A., Afik R., Bassat E., Solomonov I., Yarden Y. & Sagi I. (2016)
  • Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding

    Krupkin M., Wekselman I., Matzov D., Eyal Z., Posner Y. D., Rozenberg H., Zimmerman E., Bashan A. & Yonath A. (2016)
  • A Metabolic Gene Cluster in the Wheat W1 and the Barley Cer-cqu Loci Determines beta-Diketone Biosynthesis and Glaucousness

    Hen Avivi A. S., Savin O., Racovita R. C., Lee W., Adamski N. M., Malitsky S., Almekias-Siegl E., Levy M., Vautrin S., Berges H., Friedlander G., Kartvelishvily E., Ben-Zvi G., Alkan N., Uauy C., Kanyuka K., Jetter R., Distelfeld A. & Aharoni A. (2016)
  • 2.8-angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania

    Shalev-Benami M., Zhang Y., Matzov D., Halfon Y., Zackay A., Rozenberg H., Zimmerman E., Bashan A., Jaffe C. L., Yonath A. & Skiniotis G. (2016)
  • An Extended Cyclic Di-GMP Network in the Predatory Bacterium Bdellovibrio bacteriovorus

    Rotem O., Nesper J., Borovok I., Gorovits R., Kolot M., Pasternak Z., Shin I., Glatter T., Pietrokovski S., Jenal U. & Jurkevitch E. (2016)

    Putterman C., Safer P., Jakobi K., Sorek R., Gilkaite I., Wallace S., Altice A., Batty D. & Cohen I. R. (2016)
  • Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma.

    Grossman I., Ilani T., Fleishman S. & Fass D. (2016)
  • Transcriptome dynamics of a broad host-range cyanophage and its hosts

    Doron S., Fedida A., Hernandez-Prieto M. A., Sabehi G., Karunker I., Stazic D., Feingersch R., Steglich C., Futschik M., Lindell D. & Sorek R. (2016)
  • Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR Review 18.

    Carvalho S., Levi-Schaffer F., Sela M. & Yarden Y. (2016)
  • Extracellular Matrix Proteolysis by MT1-MMP Contributes to InfluenzaInfluenza-Related Tissue Damage and Mortality

    Talmi-Frank D., Altboum Z., Solomonov I., Ziv T., Amit I. & Sagi I. (2016)
  • An antibody to amphiregulin, an abundant growth factor in patients' fluids, inhibits ovarian tumors.

    Carvalho S., Lindzen M., Lauriola M., Shirazi N., Sinha S., Abdul-Hai A., Levanon K., Korach J., Barshack I., Cohen Y., Onn A., Mills G. & Yarden Y. (2016)
  • Quantifying remyelination in vivo - metabolic labeling of myelin in an animal model of multiple sclerosis

    Aharoni R., Rosen C., Shezen E., Sela M. & Arnon R. (2016)
  • A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism

    Eyal Z., Matzov D., Krupkin M., Paukner S., Riedl R., Rozenberg H., Zimmerman E., Bashan A. & Yonath A. (2016)
  • Harnessing the natural inhibitory domain to control TNF alpha Converting Enzyme (TACE) activity in vivo

    Wong E., Cohen T., Romi E., Levin M., Peleg Y., Arad U., Yaron A., Milla M. E. & Sagi I. (2016)
  • RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

    Tarcic O., Pateras I. S., Cooks T., Shema E., Kanterman J., Ashkenazi H., Boocholez H., Hubert A., Rotkopf R., Baniyash M., Pikarsky E., Gorgoulis V. G. & Oren M. (2016)
  • Targeting mutant p53 for cancer therapy

    Oren M., Tal P. & Rotter V. (2016)
  • Emerging anti-cancer antibodies and combination therapies targeting HER3/ERBB3

    Gaborit N., Lindzen M. & Yarden Y. (2016)
  • Elucidation of the first step in betalain biosynthesis allows the heterologous production of betalain pigments in plants

    Polturak G., Breitel D., Sarrion-Perdigones A., Grossman N., Weithorn E., Pliner M., Orzaez D., Granell A., Rogachev I. & Aharoni A. (2016)
  • A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors

    Gelfo V., Rodia M. T., Pucci M., Dall'Ora M., Santi S., Solmi R., Roth L., Lindzen M., Bonafe M., Bertotti A., Caramelli E., Lollini P., Trusolino L., Yarden Y., D'Uva G. & Lauriola M. (2016)
  • Sample Preparation for Mass Spectrometry Imaging of Plant Tissues: A Review

    Dong Y., Li B., Malitsky S., Rogachev L., Aharoni A., Kaftan F., Svatos A. & Franceschi P. (2016)
  • A Novel Allosteric Mechanism of NF-kappaB Dimerization and DNA Binding Targeted by an Anti-Inflammatory Drug.

    Ashkenazi S., Plotnikov A., Bahat A., Ben-Zeev E., Warszawski S. & Dikstein R. (2016)
  • MicroRNAs: Non-coding fine tuners of receptor tyrosine kinase signalling in cancer

    Donzelli S., Cioce M., Muti P., Strano S., Yarden Y. & Blandino G. (2016)
  • Structural Transition in Myelin Membrane as Initiator of Multiple Sclerosis

    Shaharabani R., Ram-On M., Avinery R., Aharoni R., Arnon R., Talmon Y. & Beck R. (2016)
  • Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

    Tal P., Eizenberger S., Cohen E., Goldfinger N., Pietrokovski S., Oren M. & Rotter V. (2016)
  • Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease.

    Yaeger R., Shah M. A., Miller V. A., Kelsen J. R., Wang K., Heins Z. J., Ross J. S., He Y., Sanford E., Yantiss R. K., Balasubramanian S., Stephens P. J., Schultz N., Oren M., Tang L. & Kelsen D. (2016)
  • Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

    Stock K., Estrada M. F., Vidic S., Gjerde K., Rudisch A., Santo V. E., Barbier M., Blom S., Arundkar S. C., Selvam I., Osswald A., Stein Y., Gruenewald S., Brito C., van Weerden W. W., Rotter V., Boghaert E., Oren M., Sommergruber W., Chong Y., de Hoogt H. R. & Graeser R. (2016)
  • Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

    Goldenzweig A., Goldsmith M., Hill S. E., Gertman O., Laurino P., Ashani Y., Dym O., Unger T., Albeck S., Prilusky J., Lieberman R. L., Aharoni A., Silman I., Sussman J., Tawfik D. & Fleishman S. J. (2016)
  • Matrix metalloproteinase protein inhibitors: highlighting a new beginning for metalloproteinases in medicine

    Mohan V., Talmi-Frank D., Arkadash V., Papo N. & Sagi I. (2016)
  • Tumor Evolution Inferred by Patterns of microRNA Expression through the Course of Disease, Therapy, and Recurrence in Breast Cancer

    Dadiani M., Ben-Moshe N. B., Paluch-Shimon S., Perry G., Balint N., Marin I., Pavlovski A., Bashan A., Jaffe C. L., Yonath A. & Skiniotis G. (2016)
  • CRISPR-Cas: Spacer Diversity Determines the Efficiency of Defense

    Lopatina A. & Sorek R. (2016)
  • Elucidation of the first committed step in betalain biosynthesis enables the heterologous engineering of betalain pigments in plants

    Polturak G., Breitel D., Grossman N., Sarrion-Perdigones A., Weithorn E., Pliner M., Orzaez D., Granell A., Rogachev I. & Aharoni A. (2016)
  • Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria

    Dar D., Shamir M., Mellin J. R., Koutero M., Stern-Ginossar N., Cossart P. & Sorek R. (2016)
  • Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga.

    Ziv C., Malitsky S., Othman A., Ben-Dor S., Wei Y., Zheng S., Aharoni A., Hornemann T. & Vardi A. (2016)
  • Cellular heterogeneity mediates inherent sensitivity-specificity tradeoff in cancer targeting by synthetic circuits.

    Morel M., Shtrahman R., Rotter V., Nissim L. & Bar-Ziv R. H. (2016)
  • The EGFR-HER2 module: a stem cell approach to understanding a prime target and driver of solid tumors

    Schneider M. R. & Yarden Y. (2016)
  • Examination of HER3 targeting in cancer using monoclonal antibodies

    Gaborit N., Abdul-Hai A., Mancini M., Lindzen M., Lavi S., Leitner O., Mounier L., Chentouf M., Dunoyer S., Ghosh M., Larbouret C., Chardes T., Bazin H., Pelegrine A., Sela M. & Yarden Y. (2015)
  • Single-molecule spectroscopy exposes hidden states in an enzymatic electron relay.

    Grossman I., Yuval Aviram A. H., Armony G., Horovitz A., Hofmann H., Haran G. & Fass D. (2015)
  • Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth

    Harel S., Ben-Moshe N., Aylon Y., Bublik D., Moskovits N., Toperoff G., Azaiza D., Biagoni F., Fuchs G., Wilder S., Hellman A., Blandino G., Domany E. & Oren M. (2015)
  • Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples.

    Korem T., Zeevi D., Suez J., Weinberger A., Avnit Sagi S. T., Pompan-Lotan M., Matot E., Jona G., Harmelin A., Cohen N., Sirota-Madi A., Thaiss C. A., Pevsner-Fischer M., Sorek R., Xavier R. J., Elinav E. & Segal E. (2015)
  • Diurnal suppression of EGFR signaling by glucocorticoids: implications for tumor progression and treatment

    Lauriola M., Enuka Y., Zeisel A., D'Uva G. M., Roth L., Carvalho S., Solmi R., Domany E. & Yarden Y. (2015)
  • Molecular Mechanism for LAMP1 Recognition by Lassa Virus

    Cohen-Dvashi H., Cohen N., Israeli H. & Diskin R. (2015)
  • Combining three antibodies nullifies feedback-mediated resistance to erlotinib in lung cancer

    Mancini M., Gaborit N., Lindzen M., Salame T., Dall'Ora M., Sevilla-Sharon M., Abdul-Hai A., Downward J. & Yarden Y. (2015)
  • Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases

    Oftedal B., Hellesen A., Erichsen M., Bratland E., Vardi A., Perheentupa J., Kemp E., Fiskerstrand T., Viken M., Weetman A., Fleishman S., Banka S., Newman W., Sewell W., Sozaeva L., Zayats T., Haugarvoll K., Orlova E., Haavik J., Johansson S., Knappskog P., Lovas K., Wolff A., Abramson J. & Husebye E. (2015)
  • Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy

    Golomb L., Sagiv A., Pateras I., Maly A., Krizhanovsky V., Gorgoulis V., Oren M. & Ben-Yehuda A. (2015)
  • Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1

    Vandooren J., Born B., Solomonov I., Zajac E., Saldova R., Senske M., Ugarte-Berzal E., Martens E., Van den Steen d. S. P. E., Van Damme D. J., Garcia-Pardo A., Froeyen M., Deryugina E. I., Quigley J. P., Moestrup S. K., Rudd P. M., Sagi I. & Opdenakker G. (2015)
  • Multilevel Regulation of Matrix Metalloproteinases in Tissue Homeostasis Indicates Their Molecular Specificity in vivo

    Gaffney J. P., Solomonov I., Zehorai E. & Sagi I. (2015)
  • A robust type I interferon gene signature from blood RNA defines quantitative but not qualitative differences between three major IFN beta drugs in the treatment of multiple sclerosis

    Harari D., Orr I., Rotkopf R., Baranzini S. & Schreiber G. (2015)
  • P53-dependent non-coding RNA networks in chronic lymphocytic leukemia

    Oren M. & Arundkar S. C. (2015)
  • BREX is a novel phage resistance system widespread in microbial genomes

    Goldfarb T., Sberro H., Weinstock E., Cohen O., Doron S., Charpak-Amikam Y., Afik S., Ofir G. & Sorek R. (2015)
  • Historic recollections: From polymers and proteins to autoimmunity and cancer.

    Sela M. (2015)
  • PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.

    Cohen S. G., Itkin T., Chakrabarty S., Graf C., Kollet O., Ludin A., Golan K., Kalinkovich A., Ledergor G., Wong E., Niemeyer E., Porat Z., Erez A., Sagi I., Esmon C. T., Ruf W. & Lapidot T. (2015)
  • AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences

    Lapidoth G., Baran D., Pszolla G., Norn C., Alon A., Tyka M. & Fleishman S. (2015)
  • Cancer immunotherapy: More is (much) better

    Yarden Y. & Sela M. (2015)
  • ECM remodelling in IBD: innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation

    Shimshoni E., Yablecovitch D., Baram L., Dotan I. & Sagi I. (2015)
  • Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody

    Udi Y., Grossman M., Solomonov I., Dym O., Rozenberg H., Moreno V., Cuniasse P., Dive V., Garcia Arroyo A. A. & Sagi I. (2015)
  • Fine Tuning of a Type 1 Interferon Antagonist

    Urin V., Levin D., Sharma N., Harari D. & Schreiber G. (2015)
  • The Human Otubain2-Ubiquitin Structure Provides Insights into the Cleavage Specificity of Poly-Ubiquitin-Linkages

    Altun M., Walter T. S., Kramer H. B., Herr P., Iphoefer A., Bostrom J., David Y., Komsany A., Ternette N., Navon A., Stuart D. I., Ren J. & Kessler B. M. (2015)

    Cameron K., Weinstein J., Zhivin O., Bule P., Fleishman S., Alves V., Gilbert H., Ferreira L., Fontes C., Bayer E. & Najmudin S. (2015)
  • Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.

    Eyal Z., Matzov D., Krupkin M., Wekselman I., Paukner S., Zimmerman E., Rozenberg H., Bashan A. & Yonath A. (2015)
  • Muscle composition is regulated by a Lox-TGF beta feedback loop

    Kutchuk L., Laitala A., Soueid-Bomgarten S., Shentzer P., Rosendahl A., Eilot S., Grossman M., Sagi I., Sormunen R., Myllyharju J., Maki J. M. & Hasson P. (2015)
  • EGF induces microRNAs that target suppressors of cell migration: miR-15b targets MTSS1 in breast cancer

    Kedmi M., Ben Chetrit C. N., Koerner C., Mancini M., Ben-Moshe N. B., Lauriola M., Lavi S., Biagioni F., Carvalho S., Cohen-Dvashi H., Schmitt F., Wiemann S., Blandino G. & Yarden Y. (2015)
  • Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

    Ben Chetrit C. N., Chetrit D., Russell R., Koerner C., Mancini M., Abdul-Hai A., Itkin T., Carvalho S., Cohen-Dvashi H., Koestler W. J., Shukla K., Lindzen M., Kedmi M., Lauriola M., Shulman Z., Barr H., Seger D., Ferraro D. A., Pareja F., Gil-Henn H., Alon R., Milanezi F., Symons M., Ben Hamo H. R., Efroni S., Schmitt F., Wiemann S., Caldas C., Ehrlich M. & Yarden Y. (2015)
  • Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age.

    Zwighaft Z., Aviram R., Shalev M., Rousso Noori N. L., Kraut-Cohen J., Golik M., Brandis A., Reinke H., Aharoni A., Kahana C. & Asher G. (2015)
  • Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression

    Cohen-Dvashi H., Ben Chetrit C. N., Russell R., Carvalho S., Lauriola M., Nisani S., Mancini M., Nataraj N., Kedmi M., Roth L., Koestler W., Zeisel A., Yitzhaky A., Zylberg J., Tarcic G., Eilam R., Wigelman Y., Will R., Lavi S., Porat Z., Wiemann S., Ricardo S., Schmitt F., Caldas C. & Yarden Y. (2015)
  • p53 orchestrates between normal differentiation and cancer

    Rivlin N., Koifman G. & Rotter V. (2015)
  • ErbB3-ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas

    Capparelli C., Rosenbaum S., Berman-Booty L. D., Salhi A., Gaborit N., Zhan T., Chervoneva I., Roszik J., Woodman S. E., Davies M. A., Setiady Y. Y., Osman I., Yarden Y. & Aplin A. E. (2015)
  • CRISPR adaptation biases explain preference for acquisition of foreign DNA

    Levy A., Goren M. G., Yosef I., Auster O., Manor M., Amitai G., Edgar R., Qimron U. & Sorek R. (2015)
  • Enhanced in Vivo Efficacy of a Type I Interferon Superagonist with Extended Plasma Half-life in a Mouse Model of Multiple Sclerosis

    Harari D., Kuhn N., Abramovich R., Sasson K., Zozulya A. L., Smith P., Schlapschy M., Aharoni R., Koester M., Eilam R., Skerra A. & Schreiber G. (2014)
  • EGF receptor family: twisting targets for improved cancer therapies

    Burgess A. W., Henis Y. I., Hynes N. E., Jovin T., Levitzki A., Pinkas-Kramarski R. & Yarden Y. (2014)
  • CD84 is a survival receptor for CLL cells

    Binsky-Ehrenreich I., Marom A., Sobotta M. C., Shvidel L., Berrebi A., Hazan-Halevy I., Kay S., Aloshin A., Sagi I., Goldenberg D. M., Leng L., Bucala R., Herishanu Y., Haran M. & Shachar I. (2014)
  • Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation

    Rivlin N., Katz S., Doody M., Sheffer M., Horesh S., Molchadsky A., Koifman G., Shetzer Y., Goldfinger N., Rotter V. & Geiger T. (2014)
  • p53: The barrier to cancer stem cell formation

    Aloni-Grinstein R., Shetzer Y., Kaufman T. & Rotter V. (2014)
  • Downregulation of microRNAs 145-3p and 145-5p Is a Long-term Predictor of Postmenopausal Breast Cancer Risk: The ORDET Prospective Study

    Muti P., Sacconi A., Hossain A., Donzelli S., Ben Moshe M. N. B., Ganci F., Sieri S., Krogh V., Berrino F., Biagioni F., Strano S., Beyene J., Yarden Y. & Blandino G. (2014)
  • Fur Is the Master Regulator of the Extraintestinal Pathogenic Escherichia coli Response to Serum

    Huja S., Oren Y., Biran D., Meyer S., Dobrindt U., Bernhard J., Becher D., Hecker M., Sorek R. & Ron E. Z. (2014)
  • Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ

    Solomon H., Sharon M. & Rotter V. (2014)
  • Oligodendrogenesis and myelinogenesis during postnatal development effect of glatiramer acetate

    From R., Eilam R., Bar-Lev D. D., Levin-Zaidman S., Tsoory M., LoPresti P., Sela M., Arnon R. & Aharoni R. (2014)
  • Recapitulation of non-small-cell lung carcinoma microenvironment in perfusion bioreactor cultures: the impact of hypoxia on tumour-stroma crosstalk

    Santo V., Estrada M., Veloso S., Sousa M., Van der Kuip d. K. H., Oren M., Boghaert E., Alves P. & Brito C. (2014)
  • Tumor suppressor microRNAs: A novel non-coding alliance against cancer

    Blandino G., Fazi F., Donzelli S., Kedmi M., Sas-Chen A., Muti P., Strano S. & Yarden Y. (2014)
  • Mapping the diatom redox-sensitive proteome provides insight into response to nitrogen stress in the marine environment

    Rosenwasser S., van Creveld C. S. G., Schatz D., Malitsky S., Tzfadia O., Aharoni A., Levin Y., Gabashvili A., Feldmesser E. & Vardi A. (2014)
  • Ovarian Dendritic Cells Act as a Double-Edged Pro-Ovulatory and Anti-Inflammatory Sword

    Cohen-Fredarow A., Tadmor A., Raz T., Meterani N., Addadi Y., Nevo N., Solomonov I., Sagi I., Mor G., Neeman M. & Dekel N. (2014)
  • Multifaceted Activities of Type I Interferon Are Revealed by a Receptor Antagonist

    Levin D., Schneider W. M., Hoffmann H., Yarden G., Busetto A. G., Manor O., Sharma N., Rice C. M. & Schreiber G. (2014)
  • Enzyme structure captures four cysteines aligned for disulfide relay

    Gat Y., Vardi-Kilshtain A., Grossman I., Major D. T. & Fass D. (2014)
  • Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment

    Lauriola M., Enuka Y., Zeisel A., D'Uva G., Roth L., Sharon-Sevilla M., Lindzen M., Sharma K., Nevo N., Carvalho S., Cohen-Dvashi H., Kedmi M., Ben Chetrit C. N., Chen A., Solmi R., Wiemann S., Schmitt F., Domany E. & Yarden Y. (2014)
  • An O-methyltransferase modifies accumulation of methylated anthocyanins in seedlings of tomato

    Roldan M. V. G., Outchkourov N., van Houwelingen H. A., Lammers M., de la Fuente l. F. I. R., Ziklo N., Aharoni A., Hall R. D. & Beekwilder J. (2014)
  • The Eps1p Protein Disulfide Isomerase Conserves Classic Thioredoxin Superfamily Amino Acid Motifs but Not Their Functional Geometries

    Biran S., Gat Y. & Fass D. (2014)
  • ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A

    Romi E., Gokhman I., Wong E., Antonovsky N., Ludwig A., Sagi I., Saftig P., Tessier-Lavigne M. & Yaron A. (2014)
  • Sequential capsule endoscopy of the small bowel for follow-up of patients with known Crohn's disease

    Niv E., Fishman S., Kachman H., Arnon R. & Dotan I. (2014)
  • RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38

    Weilbacher A., Gutekunst M., Oren M., Aulitzky W. E. & van der Kuip d. K. H. (2014)
  • The paradigm of mutant p53-expressing cancer stem cells and drug resistance

    Shetzer Y., Solomon H., Koifman G., Molchadsky A., Horesh S. & Rotter V. (2014)
  • Present and future breast cancer management-bench to bedside and back: a positioning paper of academia, regulatory authorities and pharmaceutical industry

    Bartsch R., Frings S., Marty M., Awada A., Berghoff A. S., Conte P., Dickin S., Enzmann H., Gnant M., Hasmann M., Hendriks H. R., Llombart A., Massacesi C., von Minckwitz M. G., Penault-Llorca F., Scaltriti M., Yarden Y., Zwierzina H. & Zielinski C. C. (2014)
  • The mutant p53-cancer stem cells and drug resistance paradigm

    Rotter V. (2014)
  • Parainflammation in cancer

    Lasry A., Hamza H., Kadosh E., Elyada E., Pribluda A., Alitalo K., Stiewe T., Oren M., Pikarsky E. & Ben-Neriah Y. (2014)
  • Sequestration of a two-component response regulator by a riboswitch-regulated noncoding RNA

    Mellin J. R., Koutero M., Dar D., Nahori M., Sorek R. & Cossart P. (2014)
  • Steering tumor progression through the transcriptional response to growth factors and stroma

    Feldman M. & Yarden Y. (2014)
  • Parainflammation in cancer

    Lasry A., Aran D., Zinger A., Hamza H., Kadosh E., Elyada E., Pribluda A., Hellman A., Oren M., Pikarsky E. & Ben-Neriah Y. (2014)
  • Proffered Paper: Regulation of NF-kB, inflammation and cancer by the E3 ligase RNF20

    Tarcic O. & Oren M. (2014)
  • Enzymatic turnover of macromolecules generates long-lasting protein-water-coupled motions beyond reaction steady state

    Dielmann-Gessner J., Grossman M., Nibali V. C., Born B., Solomonov I., Fields G. B., Havenith M. & Sagi I. (2014)
  • The inflammatory cytokine TNF alpha cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells

    Leibovich-Rivkin T., Liubomirski Y., Meshel T., Abashidze A., Brisker D., Solomon H., Rotter V., Weil M. & Ben-Baruch A. (2014)
  • SEEDSTICK is a Master Regulator of Development and Metabolism in the Arabidopsis Seed Coat

    Mizzotti C., Ezquer I., Paolo D., Rueda-Romero P., Guerra R. F., Battaglia R., Rogachev I., Aharoni A., Kater M. M., Caporali E. & Colombo L. (2014)
  • SSNMR of biosilica-entrapped enzymes permits an easy assessment of preservation of native conformation in atomic detail

    Fragai M., Luchinat C., Martelli T., Ravera E., Sagi I., Solomonov I. & Udi Y. (2014)
  • Science Signaling Podcast: 27 May 2014

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  • Pla2g16 phospholipase mediates gain-of-function activities of mutant p53

    Xiong S., Tu H., Kollareddy M., Pant V., Li Q., Zhang Y., Jackson J. G., Suh Y., Elizondo-Fraire A. C., Yang P., Chau G., Tashakori M., Wasylishen A. R., Ju Z., Solomon H., Rotter V., Liu B., El-Naggar A. K., Donehower L. A., Martinez L. A. & Lozano G. (2014)
  • Small molecules: from structural diversity to signalling and regulatory roles

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  • Complex in vitro and in vivo prostate cancer models for the PREDECT consortium

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  • Caught in the cross fire: p53 in inflammation

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  • In and out: an analysis of epibiotic vs periplasmic bacterial predators

    Pasternak Z., Njagi M., Shani Y., Chanyi R., Rotem O., Lurie-Weinberger M. N., Koval S., Pietrokovski S., Gophna U. & Jurkevitch E. (2014)
  • Affinity- and Specificity-Enhancing Mutations Are Frequent in Multispecific Interactions between TIMP2 and MMPs

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  • Enhanced in vivo efficacy of a long-life type I Interferon superagonist in a mouse model of multiple sclerosis

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  • Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

    Shingai M., Donau O., Plishka R., Buckler-White A., Mascola J., Nabel G., Nason M., Montefiori D., Moldt B., Poignard P., Diskin R., Bjorkman P., Eckhaus M., Klein F., Mouquet H., Lorenzi J., Gazumyan A., Burton D., Nussenzweig M., Martin M. & Nishimura Y. (2014)
  • Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

    Sandler N. G., Bosinger S. E., Estes J. D., Zhu R. T. R., Tharp G. K., Boritz E., Levin D., Wijeyesinghe S., Makamdop K. N., del Prete P. G. Q., Hill B. J., Timmer J. K., Reiss E., Yarden G., Darko S., Contijoch E., Todd J. P., Silvestri G., Nason M., Norgren R. B. J., Keele B. F., Rao S., Langer J. A., Lifson J. D., Schreiber G. & Douek D. C. (2014)
  • Proffered Paper: miRNA induces escape from NK cell-mediated cytotoxicity and resistance towards apoptosis in breast cancer

    Breunig C., Kublbeck M., Miller M., Antonelli D., Wirth C., Erdem N., Yarden Y., Cerwenka A. & Wiemann S. (2014)
  • Small molecules that interact with RNA: riboswitch-based gene control and its involvement in metabolic regulation in plants and algae

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  • Rewiring Host Lipid Metabolism by Large Viruses Determines the Fate of Emiliania huxleyi, a Bloom-Forming Alga in the Ocean

    Rosenwasser S., Mausz M. A., Schatz D., Sheyn U., Malitsky S., Aharoni A., Weinstock E., Tzfadia O., Ben-Dor S., Feldmesser E., Pohnert G. & Vardi A. (2014)
  • Pathways and therapeutic targets in melanoma

    Shtivelman E., Davies M. A., Hwu P., Yang J., Lotem M., Oren M., Flaherty K. T. & Fisher D. E. (2014)
  • The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

    Kiuchi T., Ortiz-Zapater E., Monypenny J., Matthews D. R., Nguyen L. K., Barbeau J., Coban O., Lawler K., Burford B., Rolfe D. J., de Rinaldis R. E., Dafou D., Simpson M. A., Woodman N., Pinder S., Gillett C. E., Devauges V., Poland S. P., Fruhwirth G., Marra P., Boersma Y. L., Plueckthun A., Gullick W. J., Yarden Y., Santis G., Winn M., Kholodenko B. N., Martin-Fernandez M. L., Parker P., Tutt A., Ameer-Beg S. M. & Ng T. (2014)
  • Enhanced in vivo efficacy using a novel long-life type I interferon variant in a mouse model of multiple sclerosis

    Harari D., Kallweit N., Abramovich R., Sasson K., Zozulya A., Smith P., Schlapschy M., Aharoni R., Koester M., Eliam R., Skerra A. & Schreiber G. (2014)
  • Unraveling Hidden Regulatory Sites in Structurally Homologous Metalloproteases

    Udi Y., Fragai M., Grossman M., Mitternacht S., Arad-Yellin R., Calderone V., Melikian M., Toccafondi M., Berezovsky I. N., Luchinat C. & Sagi I. (2013)
  • Inhibition of triple-negative breast cancer models by combinations of antibodies to EGFR

    Ferraro D. A., Gaborit N., Maron R., Cohen-Dvashi H., Porat Z., Pareja F., Lavi S., Lindzen M., Ben Chetrit C. N., Sela M. & Yarden Y. (2013)
  • CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea

    Sorek R., Lawrence C. M. & Wiedenheft B. (2013)
  • Overcoming HIV pathways for escape using rationally-designed anti-HIV antibodies

    Diskin R., Sather D. N., Marcovecchio P. M., Lee T., West A. P. J., Gao H., Klein F., Horwitz J., Seaman M. S., Stamatatos L., Nussenzweig M. C. & Bjorkman P. J. (2013)
  • Age dependent course of EAE in Aire(-/-) mice

    Aharoni R., Aricha R., Eilam R., From I., Mizrahi K., Arnon R., Souroujon M. C. & Fuchs S. (2013)
  • Mutant p53 Prolongs NF-kappa B Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

    Cooks T., Pateras I. S., Tarcic O., Solomon H., Schetter A. J., Wilder S., Lozano G., Pikarsky E., Forshew T., Rozenfeld N., Harpaz N., Itzkowitz S., Harris C. C., Rotter V., Gorgoulis V. G. & Oren M. (2013)
  • Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles

    Regev-Rudzki N., Wilson D. W., Carvalho T. G., Sisquella X., Coleman B. M., Rug M., Bursac D., Angrisano F., Gee M., Hill A. F., Baum J. & Cowman A. F. (2013)
  • Antibiotics at the Ribosomal Exit Tunnel-Selected Structural Aspects

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  • p63 Attenuates Epithelial to Mesenchymal Potential in an Experimental Prostate Cell Model

    Olsen J. R., Oyan A. M., Rostad K., Hellem M. R., Liu J., Li L., Micklem D. R., Haugen H., Lorens J. B., Rotter V., Ke X., Lin B. & Kalland K. (2013)
  • The challenges of cellular compartmentalization in plant metabolic engineering

    Heinig U., Gutensohn M., Dudareva N. & Aharoni A. (2013)
  • Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies

    Diskin R., Klein F., Horwitz J. A., Halper-Stromberg A., Sather D. N., Marcovecchio P. M., Lee T., West A. P. J., Gao H., Seaman M. S., Stamatatos L., Nussenzweig M. C. & Bjorkman P. J. (2013)
  • Endocytosis and Cancer

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  • Beta-Catenin/HuR Post-Transcriptional Machinery Governs Cancer Stem Cell Features in Response to Hypoxia

    D'Uva G., Bertoni S., Lauriola M., De Carolis C. S., Pacilli A., D'Anello L., Santini D., Taffurelli M., Ceccarelli C., Yarden Y., Montanaro L., Bonafe M. & Storci G. (2013)
  • Structural Basis for HIV-1 gp120 Recognition by a Germ-line Version of a Broadly Neutralizing Antibody

    Scharf L., West A. P., Scheid J. F., Nussenzweig M. C., Bjorkman P. J. & Diskin R. (2013)
  • High-resolution metabolic mapping of cell types in plant roots

    Moussaieff A., Rogachev I., Brodsky L., Malitsky S., Toal T. W., Belcher H., Yativ M., Brady S. M., Benfey P. N. & Aharoni A. (2013)
  • Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning

    Sberro H., Leavitt A., Kiro R., Koh E., Peleg Y., Qimron U. & Sorek R. (2013)
  • Magnetic resonance imaging characterization of different experimental autoimmune encephalomyelitis models and the therapeutic effect of glatiramer acetate

    Aharoni R., Sasson E., Blumenfeld-Katzir T., Eilam R., Sela M., Assaf Y. & Arnon R. (2013)
  • A Global Transcriptional Switch between the Attack and Growth Forms of Bdellovibrio bacteriovorus

    Karunker I., Rotem O., Dori-Bachash M., Jurkevitch E. & Sorek R. (2013)
  • A Secreted Disulfide Catalyst Controls Extracellular Matrix Composition and Function

    Ilani T., Alon A., Grossman I., Horowitz B., Kartvelishvily E., Cohen S. & Fass D. (2013)
  • Computational evaluation of cellular metabolic costs successfully predicts genes whose expression is deleterious

    Wagner A., Zarecki R., Reshef L., Gochev C., Sorek R., Gophna U. & Ruppin E. (2013)
  • Type I interferon signaling is suppressed in Experimental Autoimmune Encephalomyelitis (EAE): Implications for multiple sclerosis

    Harari D., Abramovich R., Kallweit N., Pouly S., Zozulya-Weidenfeller A., Smith P., Schlapschy M., Koester M., Hauser H., Skerra A. & Schreiber G. (2013)
  • Tomato fruits expressing a bacterial feedback-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway possess enhanced levels of multiple specialized metabolites and upgraded aroma

    Tzin V., Rogachev I., Meir S., Ben Zvi Z. M. M., Masci T., Vainstein A., Aharoni A. & Galili G. (2013)
  • 'Cancer associated fibroblasts' - more than meets the eye

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  • An Inhibitory Antibody Blocks the First Step in the Dithiol/Disulfide Relay Mechanism of the Enzyme QSOX1

    Grossman I., Alon A., Ilani T. & Fass D. (2013)
  • Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts- Secreted Interferon Beta

    Madar S., Harel E., Goldstein I., Stein Y., Kogan-Sakin I., Kamer I., Solomon H., Dekel E., Tal P., Goldfinger N., Friedlander G. & Rotter V. (2013)
  • Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs

    Hoot S., McGuire A. T., Cohen K. W., Strong R. K., Hangartner L., Klein F., Diskin R., Scheid J. F., Sather D. N., Burton D. R. & Stamatatos L. (2013)
  • Diversification of Quiescin sulfhydryl oxidase in a preserved framework for redox relay

    Limor Waisberg W. K., Ben-Dor S. & Fass D. (2013)
  • Differential Translation Tunes Uneven Production of Operon-Encoded Proteins

    Quax T. E. F., Wolf Y. I., Koehorst J. J., Wurtzel O., van der Oost d. O. R., Ran W., Blombach F., Makarova K. S., Brouns S. J. J., Forster A. C., Wagner E. G. H., Sorek R., Koonin E. V. & van der Oost d. O. J. (2013)
  • Holding a grudge: Persisting anti-phage CRISPR immunity in multiple human gut microbiomes

    Mick E., Stern A. & Sorek R. (2013)
  • Inhibition of pancreatic carcinoma by homo- and heterocombinations of antibodies against EGF-receptor and its kin HER2/ErbB-2

    Maron R., Schechter B., Mancini M., Mahlknecht G., Yarden Y. & Sela M. (2013)
  • Now at the Met: Fine Art of Reversible Sulfoxidation

    Ilani T. & Fass D. (2013)
  • Oriented Covalent Immobilization of Antibodies for Measurement of Intermolecular Binding Forces between Zipper-Like Contact Surfaces of Split Inteins

    Sorci M., Dassa B., Liu H., Anand G., Dutta A. K., Pietrokovski S., Belfort M. & Belfort G. (2013)
  • Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53

    Goldstein I., Rivlin N., Shoshana O., Ezra O., Madar S., Goldfinger N. & Rotter V. (2013)
  • CD84 is a survival receptor for chronic lymphocytic leukemia cells

    Marom A., Binsky-Ehrenreich I., Sobotta M., Shvidel L., Berrebi A., Hazan-Halevy I., Kay S., Aloshin A., Sagi I., Goldenberg D., Leng L., Bucala R., Herishanu Y., Haran M. & Shachar I. (2013)
  • A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

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  • Basic cancer research is essential for the success of personalised medicine

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  • The locus of microRNA-10b A critical target for breast cancer insurgence and dissemination

    Biagioni F., Ben-Moshe N. B., Fontemaggi G., Yarden Y., Domany E. & Blandino G. (2013)
  • p53 Counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition

    Brosh R., Assia-Alroy Y., Molchadsky A., Bornstein C., Dekel E., Madar S., Shetzer Y., Rivlin N., Goldfinger N., Sarig R. & Rotter V. (2013)
  • The excludon: a new concept in bacterial antisense RNA-mediated gene regulation

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  • By their genes ye shall know them: genomic signatures of predatory bacteria

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  • Targeting ErbB-1 and ErbB-4 in irradiated head and neck cancer: Results of in vitro and in vivo studies

    Barnea I., Haif S., Keshet R., Karaush V., Lev-Ari S., Khafif A., Shtabsky A., Yarden Y., Vexler A. & Ben Yosef Y. R. (2013)
  • Formation of protein complexes in crowded environments - From in vitro to in vivo

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  • Emerging themes in the computational design of novel enzymes and protein-protein interfaces

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  • Computational Design of a Protein-Based Enzyme Inhibitor

    Procko E., Hedman R., Hamilton K., Seetharaman J., Fleishman S. J., Su M., Aramini J., Kornhaber G., Hunt J. F., Tong L., Montelione G. T. & Baker D. (2013)
  • Transcriptome-Wide Mapping of 5-methylcytidine RNA Modifications in Bacteria, Archaea, and Yeast Reveals m(5)C within Archaeal mRNAs

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  • Aptamer to ErbB-2/HER2 enhances degradation of the target and inhibits tumorigenic growth

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  • Transcriptional Control by NF-kappa B: Elongation in Focus

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  • Orchestration of Thiamin Biosynthesis and Central Metabolism by Combined Action of the Thiamin Pyrophosphate Riboswitch and the Circadian Clock in Arabidopsis

    Bocobza S. E., Malitsky S., Araujo W. L., Nunes-Nesi A., Meir S., Shapira M., Fernie A. R. & Aharoni A. (2013)
  • In Vitro Microbiotic Fermentation Causes an Extensive Metabolite Turnover of Rye Bran Phytochemicals

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  • The dynamic disulphide relay of quiescin sulphydryl oxidase

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  • RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation

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  • Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling

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  • Comparative transcriptomics of pathogenic and non-pathogenic Listeria species

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  • The Direction of Protein Entry into the Proteasome Determines the Variety of Products and Depends on the Force Needed to Unfold Its Two Termini

    Berko D., Tabachnick-Cherny S., Shental-Bechor D., Cascio P., Mioletti S., Levy Y., Admon A., Ziv T., Tirosh B., Goldberg A. L. & Navon A. (2012)
  • Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis

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  • Asymmetric adaptation to indolic and aliphatic glucosinolates in the B and Q sibling species of Bemisia tabaci (Hemiptera: Aleyrodidae)

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  • Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

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  • Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues

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  • Evolutionary perspective on distinct features of GSK-3 isozymes

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  • HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

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  • Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

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  • Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions

    Pradeep C., Zeisel A., Koestler W. J., Lauriola M., Jacob-Hirsch J., Haibe-Kains B., Amariglio N., Ben Chetrit C. N., Emde A. M., Solomonov I., Neufeld G., Piccart M., Sagi I., Sotiriou C., Rechavi G., Domany E., Desmedt C. & Yarden Y. (2012)

    Yarden Y. (2012)
  • A vast collection of microbial genes that are toxic to bacteria

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  • Crosstalk of cancer cells and cancer associated fibroblasts in the p53 response to Cisplatin in intact tissues from NSCLC specimen

    Schmid J. O., Dong M., Haubeiss S., Friedel G., Oren M., Muerdter T., Aulitzky W. E. & van der Kuip d. K. H. (2012)
  • UPLC-MS-based metabolite analysis in tomato

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  • Diverse Functions of IGF/Insulin Signaling in Malignant and Noncancerous Prostate Cells: Proliferation in Cancer Cells and Differentiation in Noncancerous Cells

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  • The ERBB network: at last, cancer therapy meets systems biology

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  • Exploring ORFan Domains in Giant Viruses: Structure of Mimivirus Sulfhydryl Oxidase R596

    Hakim M., Ezerina D., Alon A., Vonshak O. & Fass D. (2012)
  • RNA-seq analysis of small RNPs in Trypanosoma brucei reveals a rich repertoire of non-coding RNAs

    Michaeli S., Doniger T., Gupta S. K., Wurtzel O., Romano M., Visnovezky D., Sorek R., Unger R. & Ullu E. (2012)
  • Cancer Cells Cue the p53 Response of Cancer-Associated Fibroblasts to Cisplatin

    Schmid J. O., Dong M., Haubeiss S., Friedel G., Bode S., Grabner A., Ott G., Muerdter T. E., Oren M., Aulitzky W. E. & van der Kuip d. K. H. (2012)
  • A Crossroad of microRNAs and Immediate Early Genes (IEGs) Encoding Oncogenic Transcription Factors in Breast Cancer

    Sas-Chen A., Avraham R. & Yarden Y. (2012)
  • miR-10b*, a master inhibitor of the cell cycle, is down-regulated in human breast tumours

    Biagioni F., Ben-Moshe N. B., Fontemaggi G., Canu V., Mori F., Antoniani B., Di Benedetto B. A., Santoro R., Germoni S., De Angelis A. F., Cambria A., Avraham R., Grasso G., Strano S., Muti P., Mottolese M., Yarden Y., Domany E. & Blandino G. (2012)
  • Formation of Protein-Complexes in crowded environments: From in vitro to in vivo

    Schreiber G. & Phillip Y. (2012)
  • Co-mapping studies of QTLs for fruit acidity and candidate genes of organic acid metabolism and proton transport in sweet melon (Cucumis melo L.)

    Cohen S., Tzuri G., Harel-Beja R., Itkin M., Portnoy V., Sa'ar U., Lev S., Yeselson L., Petrikov M., Rogachev I., Aharoni A., Ophir R., Tadmor Y., Lewinsohn E., Burger Y., Katzir N. & Schaffer A. A. (2012)
  • Reconstruction of Arabidopsis metabolic network models accounting for subcellular compartmentalization and tissue-specificity

    Mintz-Oron S., Meir S., Malitsky S., Ruppin E., Aharoni A. & Shlomi T. (2012)
  • Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression

    Pareja F., Ferraro D. A., Rubin C., Cohen-Dvashi H., Zhang F., Aulmann S., Ben Chetrit C. N., Pines G., Navon R., Crosetto N., Koestler W., Carvalho S., Lavi S., Schmitt F., Dikic I., Yakhini Z., Sinn P., Mills G. B. & Yarden Y. (2012)

    Yarden Y. (2012)
  • Identification of CTCF as a master regulator of the clustered protocadherin genes

    Golan Mashiach M. M., Grunspan M., Emmanuel R., Gibbs-Bar L., Dikstein R. & Shapiro E. (2012)
  • Cancer research, a field on the verge of a paradigm shift?

    Goldstein I., Madar S. & Rotter V. (2012)
  • Mutant p53(R273H) attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species

    Kalo E., Kogan-Sakin I., Solomon H., Bar-Nathan E., Shay M., Shetzer Y., Dekel E., Goldfinger N., Buganim Y., Stambolsky P., Goldstein I., Madar S. & Rotter V. (2012)
  • CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome

    Stern A., Mick E., Tirosh I., Sagy O. & Sorek R. (2012)
  • Inflammatory control of colorectal cancer progression

    Ben-Neriah Y., Pribluda A., Elyada E., Snir-Alkalay I., Pikarsky E., Oren M., Wiener Z. & Alitalo K. (2012)
  • Expression of a bacterial feedback-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway in Arabidopsis elucidates potential metabolic bottlenecks between primary and secondary metabolism

    Tzin V., Malitsky S., Ben Zvi Z. M. M., Bedair M., Sumner L., Aharoni A. & Galili G. (2012)
  • Network and Systems Biology in Cancer

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  • Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation

    Piehler J., Thomas C., Garcia K. C. & Schreiber G. (2012)
  • A recombinant decoy comprising EGFR and ErbB-4 inhibits tumor growth and metastasis

    Lindzen M., Carvalho S., Starr A., Ben Chetrit C. N., Pradeep C., Koestler W. J., Rabinkov A., Lavi S., Bacus S. S. & Yarden Y. (2012)
  • Zn2+-A beta 40 Complexes Form Metastable Quasi-spherical Oligomers That Are Cytotoxic to Cultured Hippocampal Neurons

    Solomonov I., Korkotian E., Born B., Feldman Y. (., Bitler A., Rahimi F., Li H., Bitan G. & Sagi I. (2012)
  • Fruit cuticular and agronomic characteristics of a lecer6 mutant of tomato

    Ehret D. L., Frey B., Helmer T., Aharoni A., Wang Z. & Jetter R. (2012)
  • Phylogenetics and enzymology of plant quiescin sulfhydryl oxidase

    Limor Waisberg W. K., Alon A., Mehlman T. & Fass D. (2012)
  • DSIF Restricts NF-kappa B Signaling by Coordinating Elongation with mRNA Processing of Negative Feedback Genes

    Diamant G., Amir-Zilberstein L., Yamaguchi Y., Handa H. & Dikstein R. (2012)
  • DePICTing p53 Activation: A New Nucleolar Link to Cancer

    Golomb L. & Oren M. (2011)
  • TMPRSS2/ERG Promotes Epithelial to Mesenchymal Transition through the ZEB1/ZEB2 Axis in a Prostate Cancer Model

    Leshem O., Madar S., Kogan-Sakin I., Kamer I., Goldstein I., Brosh R., Cohen Y., Jacob-Hirsch J., Ehrlich M., Ben-Sasson S., Goldfinger N., Loewenthal R., Gazit E., Rotter V. & Berger R. (2011)
  • Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression

    Buganim Y., Madar S., Rais Y., Pomeraniec L., Harel E., Solomon H., Kalo E., Goldstein I., Brosh R., Haimov O., Avivi C., Polak-Charcon S., Goldfinger N., Barshack I. & Rotter V. (2011)
  • Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model

    Ke X., Li W., Hovland R., Qu Y., Liu R., McCormack E., Thorsen F., Olsen J. R., Molven A., Kogan-Sakin I., Rotter V., Akslen L. A., Oyan A. M. & Kalland K. (2011)
  • Overview of Vaccine Strategies

    Arnon R. (2011)
  • Distinct pathological patterns in relapsing-remitting and chronic models of experimental autoimmune enchephalomyelitis and the neuroprotective effect of glatiramer acetate

    Aharoni R., Vainshtein A., Stock A., Eilam R., From R., Shinder V. & Arnon R. (2011)
  • Mutant p53 gain of function is interwoven into the hallmarks of cancer

    Solomon H., Madar S. & Rotter V. (2011)
  • Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit

    Belousoff M. J., Shapira T., Bashan A., Zimmerman E., Rozenberg H., Arakawa K., Kinashi H. & Yonath A. (2011)
  • The Biological Framework: Translational Research from Bench to Clinic

    Yarden Y. (2011)
  • Carcinogen-Induced Hepatic Tumors in KLF6+/- Mice Recapitulate Aggressive Human Hepatocellular Carcinoma Associated with p53 Pathway Deregulation

    Tarocchi M., Hannivoort R., Hoshida Y., Lee U. E., Vetter D., Narla G., Villanueva A., Oren M., Llovet J. M. & Friedman S. L. (2011)
  • Bacterial genomes: from regulatory complexity to engineering

    Sorek R. & Serrano L. (2011)
  • Convergence of Logic of Cellular Regulation in Different Premalignant Cells by an Information Theoretic Approach

    Kravchenko-Balasha N., Remacle F., Gross A., Rotter V., Levitzki A. & Levine R. D. (2011)
  • Structure of a Baculovirus Sulfhydryl Oxidase, a Highly Divergent Member of the Erv Flavoenzyme Family

    Hakim M., Mandelbaum A. & Fass D. (2011)
  • The Glial Scar-Monocyte Interplay: A Pivotal Resolution Phase in Spinal Cord Repair

    Shechter R., Raposo C., London A., Sagi I. & Schwartz M. (2011)
  • The EGFR/ErbB Family in Breast Cancer: From Signalling to Therapy

    Koestler W. J. & Yarden Y. (2011)
  • Stochastic Receptor Expression Determines Cell Fate upon Interferon Treatment

    Levin D., Harari D. & Schreiber G. (2011)
  • Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

    Goldstein I., Marcel V., Olivier M., Oren M., Rotter V. & Hainaut P. (2011)
  • Beneficial Effect of Glatiramer Acetate Treatment on Syndecan-1 Expression in Dextran Sodium Sulfate Colitis

    Yablecovitch D., Shabat Simon S. M., Aharoni R., Eilam R., Brenner O. & Arnon R. (2011)
  • E3 Ligases Determine Ubiquitination Site and Conjugate Type by Enforcing Specificity on E2 Enzymes

    David Y., Ternette N., Edelmann M. J., Ziv T., Gayer B., Sertchook R., Dadon Y., Kessler B. M. & Navon A. (2011)
  • Binding and activity of all human alpha interferon subtypes

    Lavoie T. B., Kalie E., Crisafulli-Cabatu S., Abramovich R., DiGioia G., Moolchan K., Pestka S. & Schreiber G. (2011)

    Aharoni R., Eilam R., Stock A., Vainshtein A., From R. & Arnon R. (2011)
  • New opportunities in drug design of metalloproteinase inhibitors: combination between structure-function experimental approaches and systems biology

    Sela-Passwell N., Trahtenherts A., Krueger A. & Sagi I. (2011)
  • Probing Conformational Variations at the ATPase Site of the RNA Helicase DbpA by High-Field Electron-Nuclear Double Resonance Spectroscopy

    Kaminker I., Sushenko A., Potapov A., Daube S., Akabayov B., Sagi I. & Goldfarb D. (2011)
  • Activity, specificity and structure of I-Bth0305I: a representative of a new homing endonuclease family

    Taylor G. K., Heiter D. F., Pietrokovski S. & Stoddard B. L. (2011)
  • Peptides and Polypeptides as Immunomodulators and Their Consequential Therapeutic Effect in Multiple Sclerosis and Other Autoimmune Diseases

    Arnon R., Sela M. & Aharoni R. (2011)
  • Qualitative Characterization of Benzoxazinoid Derivatives in Whole Grain Rye and Wheat by LC-MS Metabolite Profiling

    Hanhineva K., Rogachev I., Aura A., Aharoni A., Poutanen K. & Mykkanen H. (2011)
  • Metabolic engineering of the plant primary-secondary metabolism interface

    Aharoni A. & Galili G. (2011)
  • Two Phases of Mitogenic Signaling Unveil Roles for p53 and EGR1 in Elimination of Inconsistent Growth Signals

    Zwang Y., Sas-Chen A., Drier Y., Shay T., Avraham R., Lauriola M., Shema E., Lidor Nili N. E., Jacob-Hirsch J., Amariglio N., Lu Y., Mills G. B., Rechavi G., Oren M., Domany E. & Yarden Y. (2011)
  • Distinct Molecular Regulation of Glycogen Synthase Kinase-3 alpha Isozyme Controlled by Its N-terminal Region FUNCTIONAL ROLE IN CALCIUM/CALPAIN SIGNALING

    Azoulay-Alfaguter I., Yaffe Y., Licht-Murava A., Urbanska M., Jaworski J., Pietrokovski S., Hirschberg K. & Eldar-Finkelman H. (2011)
  • The phage-host arms race: Shaping the evolution of microbes

    Stern A. & Sorek R. (2011)
  • Selective loss of glycogen synthase kinase-3 alpha in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

    Alon L. T., Pietrokovski S., Barkan S., Avrahami L., Kaidanovich-Beilin O., Woodgett J. R., Barnea A. & Eldar-Finkelman H. (2011)
  • Protein binding specificity versus promiscuity

    Schreiber G. & Keating A. E. (2011)
  • Glatiramer acetate (GA, Copolymer-1) an hypothetical treatment option for Rett syndrome

    Ben-Zeev B., Aharoni R., Nissenkorn A. & Arnon R. (2011)
  • The synchrotron radiation and the ribosome

    Rozenberg H. & Yonath A. (2011)

    Aharoni R., Eilam R., Stock A., Vainshtein A. & Arnon R. (2011)
  • Genomic island variability facilitates Prochlorococcus-virus coexistence

    Avrani S., Wurtzel O., Sharon I., Sorek R. & Lindell D. (2011)
  • Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer

    Tabach Y., Kogan-Sakin I., Buganim Y., Solomon H., Goldfinger N., Hovland R., Ke X., Oyan A. M., Kalland K., Rotter V. & Domany E. (2011)
  • Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site

    Grossman M., Born B., Heyden M., Tworowski D., Fields G. B., Sagi I. & Havenith M. (2011)
  • Unleash the wild type: Restoration of p53 suppressive activity in skin cancer

    Madar S., Stambolsky P. & Rotter V. (2011)
  • Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

    Thomas C., Moraga I., Levin D., Krutzik P. O., Podoplelova Y., Trejo A., Lee C., Yarden G., Vleck S. E., Glenn J. S., Nolan G. P., Piehler J., Schreiber G. & Garcia K. C. (2011)
  • Combining epitope-distinct antibodies to HER2: cooperative inhibitory effects on invasive growth

    Emde A. M., Pradeep C., Ferraro D. A., Ben Chetrit C. N., Sela M., Ribba B., Kam Z. & Yarden Y. (2011)
  • p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes

    Rinon A., Molchadsky A., Nathan E., Yovel G., Rotter V., Sarig R. & Tzahor E. (2011)
  • Generation and characterization of peptide mimotopes specific for anti ErbB-2 monoclonal antibodies

    Witsch E. J., Mahlknecht G., Wakim J., Sertchook R., Bublil E., Yarden Y. & Sela M. (2011)
  • Simultaneous Inhibition of Estrogen Receptor and the HER2 Pathway in Breast Cancer: Effects of HER2 Abundance

    Emde A., Mahlknecht G., Maslak K., Ribba B., Sela M., Possinger K. & Yarden Y. (2011)
  • Mutant p53 Gain-of-Function in Cancer

    Oren M. & Rotter V. (2010)
  • The ribosome as drug target: lessons from 3D structures

    Zaytzev-Bashan A., Zimmerman E., Belousoff M., Rozenberg H., Davidovich C., Wekselman I., Shapira T., Krupkin M. & Yonath A. (2010)
  • p53 is balancing development, differentiation and de-differentiation to assure cancer prevention

    Molchadsky A., Rivlin N., Brosh R., Rotter V. & Sarig R. (2010)
  • Substrate Competitive GSK-3 Inhibitors - strategy and Implications

    Eldar-Finkelman H., Licht-Murava A., Pietrokovski S. & Eisenstein M. (2010)
  • Self-targeting by CRISPR: gene regulation or autoimmunity?

    Stern A., Keren L., Wurtzel O., Amitai G. & Sorek R. (2010)
  • Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53

    Stambolsky P., Tabach Y., Fontemaggi G., Weisz L., Maor-Aloni R., Sigfried Z., Shiff I., Kogan I., Shay M., Kalo E., Blandino G., Simon I., Oren M. & Rotter V. (2010)
  • Feedback control of receptor tyrosine kinases: multiple defects in cancer

    Yarden Y. (2010)
  • Steps in reductive activation of the disulfide-generating enzyme Ero1p

    Heldman N., Vonshak O., Sevier C. S., Vitu E., Mehlman T. & Fass D. (2010)
  • Tailored cancer immunotherapy using combinations of chemotherapy and a mixture of antibodies against EGF-receptor ligands

    Lindzen M., Lavi S., Leitner O. & Yarden Y. (2010)
  • The Rebirth of a Phoenix: Ovarian Cancers Are Addicted to ErbB-3

    Mills G. B. & Yarden Y. (2010)
  • Cytokine-receptor interactions as drug targets

    Schreiber G. & Walter M. R. (2010)
  • Polar Bears, Antibiotics, and the Evolving Ribosome (Nobel Lecture)

    Yonath A. (2010)
  • Prokaryotic transcriptomics: a new view on regulation, physiology and pathogenicity

    Sorek R. & Cossart P. (2010)
  • A Novel Translocation Breakpoint within the BPTF Gene Is Associated with a Pre-Malignant Phenotype

    Buganim Y., Goldstein I., Lipson D., Milyavsky M., Polak-Charcon S., Mardoukh C., Solomon H., Kalo E., Madar S., Brosh R., Perelman M., Navon R., Goldfinger N., Barshack I., Yakhini Z. & Rotter V. (2010)
  • Repression of transposable-elements - a microRNA anti-cancer defense mechanism?

    Shalgi R., Pilpel Y. & Oren M. (2010)
  • Direct Visualization of Protease Action on Collagen Triple Helical Structure

    Rosenblum G., Van den Steen d. S. P. E., Cohen S., Bitler A., Brand D. D., Opdenakker G. & Sagi I. (2010)
  • Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing-remitting or chronic EAE

    Aharoni R., Eilam R., Stock A., Vainshtein A., Shezen E., Gal H., Friedman N. & Arnon R. (2010)
  • Structural and functional bases for allosteric control of MMP activities: Can it pave the path for selective inhibition?

    Sela-Passwell N., Rosenblum G., Shoham T. & Sagi I. (2010)
  • The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics

    Auerbach T., Mermershtain I., Davidovich C., Bashan A., Belousoff M., Wekselman I., Zimmerman E., Xiong L., Klepacki D., Arakawa K., Kinashi H., Mankin A. S. & Yonath A. (2010)
  • Oncogenic mutant forms of EGFR: Lessons in signal transduction and targets for cancer therapy

    Pines G., Koestler W. J. & Yarden Y. (2010)
  • Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

    Spangler J. B., Neil J. R., Abramovitch S., Yarden Y., White F. M., Lauffenburger D. A. & Wittrup K. D. (2010)
  • p53 Regulates the Ras Circuit to Inhibit the Expression of a Cancer-Related Gene Signature by Various Molecular Pathways

    Buganim Y., Solomon H., Rais Y., Kistner D., Nachmany I., Brait M., Madar S., Goldstein I., Kalo E., Adam N., Gordin M., Rivlin N., Kogan I., Brosh R., Sefadia-Elad G., Goldfinger N., Sidransky D., Kloog Y. & Rotter V. (2010)
  • A Small Molecule Inhibitor of Endoplasmic Reticulum Oxidation 1 (ERO1) with Selectively Reversible Thiol Reactivity

    Blais J. D., Chin K., Zito E., Zhang Y., Heldman N., Harding H. P., Fass D., Thorpe C. & Ron D. (2010)
  • Ancient machinery embedded in the contemporary ribosome

    Belousoff M. J., Davidovich C., Zimmerman E., Caspi Y., Wekselman I., Rozenszajn L., Shapira T., Sade-Falk O., Taha L., Bashan A., Weiss M. S. & Yonath A. (2010)
  • Mutation Detection with Next-Generation Resequencing through a Mediator Genome

    Wurtzel O., Dori-Bachash M., Pietrokovski S., Jurkevitch E. & Sorek R. (2010)
  • TAF4b and Jun/Activating Protein-1 Collaborate to Regulate the Expression of Integrin alpha 6 and Cancer Cell Migration Properties

    Kalogeropoulou M., Voulgari A., Kostourou V., Sandaltzopoulos R., Dikstein R., Davidson I., Tora L. & Pintzas A. (2010)
  • The HER2 and EGFR alliance in cancer: defects in system control

    Yarden Y. (2010)
  • p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation

    Scherz-Shouval R., Weidberg H., Gonen C., Wilder S., Elazar Z. & Oren M. (2010)
  • An Orange Ripening Mutant Links Plastid NAD(P)H Dehydrogenase Complex Activity to Central and Specialized Metabolism during Tomato Fruit Maturation

    Nashilevitz S., Melamed-Bessudo C., Izkovich Y., Rogachev I., Osorio S., Itkin M., Adato A., Pankratov I., Hirschberg J., Fernie A. R., Wolf S., Usadel B., Levy A., Rumeau D. & Aharoni A. (2010)
  • Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma

    Schilling T., Kairat A., Melino G., Krammer P. H., Stremmel W., Oren M. & Mueller M. (2010)
  • Reduced interferon receptor levels resulting from either knockdown or prolonged Type I interferon treatment promote a shift in cellular responsiveness

    Harari D., Levin D., Abramovich R. & Schreiber G. (2010)
  • Involvement of stromal p53 in tumor-stroma interactions

    Bar J., Moskovits N. & Oren M. (2010)
  • Roles for Growth Factors in Cancer Progression

    Witsch E., Sela M. & Yarden Y. (2010)
  • Hunting for Alternative Disulfide Bond Formation Pathways: Endoplasmic Reticulum Janitor Turns Professor and Teaches a Lesson

    Fass D. (2010)
  • QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains

    Alon A., Heckler E. J., Thorpe C. & Fass D. (2010)
  • Cytosolic Disulfide Bond Formation in Cells Infected with Large Nucleocytoplasmic DNA Viruses

    Hakim M. & Fass D. (2010)
  • p53 and cancer: a complex affair

    Oren M. (2010)

    Tori K., Dassa B., Johnson M. A., Southworth M. W., Brace L. E., Ishino Y., Pietrokovski S. & Perler F. B. (2010)
  • The E2 Ubiquitin-conjugating Enzymes Direct Polyubiquitination to Preferred Lysines

    David Y., Ziv T., Admon A. & Navon A. (2010)
  • Transcriptional control of the proliferation cluster by the tumor suppressor p53

    Brosh R. & Rotter V. (2010)
  • p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

    Brosh R., Sarig R., Bar Natan N. E., Molchadsky A., Madar S., Bornstein C., Buganim Y., Shapira T., Goldfinger N., Paus R. & Rotter V. (2010)
  • The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function

    Grossman M., Tworowski D., Dym O., Lee M., Levy Y., Murphy G. & Sagi I. (2010)
  • The Biological Framework: Translational Research from Bench to Clinic

    Yarden Y. (2010)
  • A single-base resolution map of an archaeal transcriptome

    Wurtzel O., Sapra R., Chen F., Zhu Y., Simmons B. A. & Sorek R. (2010)
  • A comparison of the binding of Interferon alpha subtypes to isolated IFNAR1 and IFNAR2 with activity in antiviral and antiproliferative assays

    Lavoie T. B., Abramovich R., Cabatu S. C., DiGioia G., Moolchan K., Pestka S. & Schreiber G. (2010)