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  • Immunotherapy and big data
    Single cell multiomics

    Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through FcγR engagement and type I interferon signaling

    Yofe I., Landsberger T., Yalin A., el al.

  • Single cell multiomics

    The industrial genomic revolution: A new era in neuroimmunology

    Shalita R., Amit I.

  • Antibody engineering
    Single cell multiomics

    Bispecific antibodies increase the therapeutic window of CD40 agonists through selective dendritic cell targeting

    Salomon R., Rotem H., Katzenelenbogen Y., Weiner A., Cohen Saban N., Feferman T., Amit I. & Dahan R. (2022) Nature Cancer.

  • Antibody engineering

    Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism

    He C., Maniyar R. R., Avraham Y. et al. (2022) Science advances.

  • Protein design

    Structure and receptor recognition by the Lassa virus spike complex

    Katz M., Weinstein J., Eilon-Ashkenazy M., Gehring K., Cohen-Dvashi H., Elad N., Fleishman S. J. & Diskin R. (2022) Nature.

  • Single cell multiomics

    Early antitumor activity of oral Langerhans cells is compromised by a carcinogen

    Saba Y., et al. (2022) Proceedings of the National Academy of Sciences.

  • Immunotherapy and big data

    Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

    Spencer C. N., McQuade J. L., Gopalakrishnan V. et_al. (2021) Science.

  • Immunotherapy and big data
    Single cell multiomics

    Tumor cells in light-chain amyloidosis and myeloma show different transcriptional rewiring of normal plasma cell development

    Alameda D., et al. (2021) Blood.

  • Immunotherapy and big data
    Single cell multiomics

    Evolutionary cell type mapping with single-cell genomics

    Tanay A. & Sebé-Pedrós A. (2021) Trends in Genetics.

  • Protein design

    Extending the New Generation of Structure Predictors to Account for Dynamics and Allostery

    Fleishman S. J. & Horovitz A. (2021) Journal of Molecular Biology.

  • Immunotherapy and big data

    IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy

    Jacob Berger A., Gigi E., Kupershmidt L. et_al. (2021) Nature Cancer.

  • Immunotherapy and big data

    DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

    Batra R. N., Lifshitz A., Vidakovic A. T. et_al. (2021) Nature Communications.

  • Single cell multiomics

    Single-cell analysis of regions of interest (SCARI) using a photosensitive tag

    van der Leun A. M., et al. (2021) Nature Chemical Biology.

  • Antibody engineering
    Protein design

    Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies

    Borenstein-Katz A., Warszawski S., Amon R. et_al. (2021) Journal of Molecular Biology.

  • Protein design

    Community-Wide Experimental Evaluation of the PROSS Stability-Design Method

    Peleg Y., Vincentelli R., Collins B. M. et_al. (2021) Journal of Molecular Biology.

  • Immunotherapy and big data
    Single cell multiomics
    Cell therapy

    Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation

    McFarland A. P., et al. (2021) Immunity.

  • Immunotherapy and big data
    Single cell multiomics

    Clump sequencing exposes the spatial expression programs of intestinal secretory cells

    Manco R., et al. (2021) Nature Communications.

  • Immunotherapy and big data
    Cell therapy

    Melanoma models for the next generation of therapies

    Patton E. E., Mueller K. L., Adams D. J. et_al. (2021) Cancer Cell.

  • Antibody engineering

    Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

    Dubiella C., Pinch B. J., Koikawa K. et al. (2021) Nature Chemical Biology.

  • Immunotherapy and big data
    Single cell multiomics

    Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma

    Jansky S., Sharma A. K., Körber V. et_al. (2021) Nature Genetics.

  • Immunotherapy and big data
    Single cell multiomics

    NASH limits anti-tumour surveillance in immunotherapy-treated HCC

    Pfister D., et al. (2021) Nature.

  • Immunotherapy and big data
    Cell therapy

    Identification of bacteria-derived HLA-bound peptides in melanoma

    Kalaora S., Nagler A., Nejman D. et_al. (2021) Nature.

  • Immunotherapy and big data
    Cell therapy

    MEK inhibition reverses aberrant signaling in melanoma cells through reorganization of NRas and BRAF in self nano-clusters

    Yakovian O., Sajman J., Arafeh R., Neve-Oz Y., Alon M., Samuels Y. & Sherman E. (2021) Cancer research.

  • Immunotherapy and big data
    Single cell multiomics

    Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing

    Zada M., Wang S., Bornstein C., et al. (2021) Nature Medicine.

  • Protein design

    PROSS 2: a new server for the design of stable and highly expressed protein variants

    Weinstein J. J., Goldenzweig A., Hoch S. & Fleishman S. J. (2020) Bioinformatics.

  • Immunotherapy and big data
    Single cell multiomics

    A single cell atlas of the human liver tumor microenvironment

    Massalha H., et al. (2020) Molecular Systems Biology.

  • Immunotherapy and big data

    Anti-tumour immunity induces aberrant peptide presentation in melanoma

    Bartok O., Pataskar A., Nagel R. et al. (2020) Nature.

  • Immunotherapy and big data

    Donor cell leukemia: reappearance of gene mutations in donor cells - more than an incidental phenomenon?

    Shahar Gabay T., Chapal-Ilani N., Moskovitz Y. et_al. (2020) Haematologica.

  • Protein design

    The AbDesign computational pipeline for modular backbone assembly and design of binders and enzymes

    Lipsh‐Sokolik R., Listov D. & Fleishman S. J. (2020) Protein Science.

  • Immunotherapy and big data
    Single cell multiomics

    Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

    Katzenelenbogen Y., Sheban F., Yalin A., et al. (2020) Cell.

  • Protein design

    Practically useful protein-design methods combining phylogenetic and atomistic calculations

    Weinstein J., Khersonsky O. & Fleishman S. J. (2020) Current Opinion in Structural Biology.

  • Immunotherapy and big data
    Single cell multiomics

    Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma

    Chen Y., et al. (2020) Cell Research.

  • Immunotherapy and big data

    PhISCS-BnB: a fast branch and bound algorithm for the perfect tumor phylogeny reconstruction problem

    Sadeqi Azer E., Rashidi Mehrabadi F., Malikić S. et_al. (2020) Bioinformatics.

  • Immunotherapy and big data
    Single cell multiomics

    Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4(+) and PDPN+ CAFs to clinical outcome

    Friedman G., et al. (2020) Nature Cancer.

  • Immunotherapy and big data
    Single cell multiomics

    Single-cell analysis of clonal maintenance of transcriptional and epigenetic states in cancer cells

    Meir Z., Mukamel Z., Chomsky E., Lifshitz A. & Tanay A. (2020) Nature Genetics.

  • Immunotherapy and big data
    Single cell multiomics

    The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

    Deczkowska A., et al. (2020) Cell.

  • Immunotherapy and big data
    Cell therapy

    A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma

    Nagler A., Vredevoogd D. W., Alon M. et_al. (2020) Pigment Cell and Melanoma Research.

  • Immunotherapy and big data
    Single cell multiomics

    Single-cell analysis illuminates dysfunctional CD8+T cells as a proliferative, dynamically regulated compartment within human melanoma.

    Yofe I., et al. (2020) Cancer immunology research.

  • Immunotherapy and big data
    Single cell multiomics

    Dissecting cellular crosstalk by sequencing physically interacting cells

    Giladi A., Cohen M., et al. (2020) Nature Biotechnology.

  • Immunotherapy and big data
    Single cell multiomics

    Bystander IFN-gamma activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

    Thibaut R., et al. (2020) Nature Cancer.

  • Immunotherapy and big data
    Single cell multiomics

    Single-cell analysis reveals the pivotal role of the innate immune compartment in aCTLA-4 antitumor response.

    Yofe I., et al. (2020) Cancer immunology research.

  • Immunotherapy and big data

    Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma

    Kalaora S., Lee J. S., Barnea E. et_al. (2020) Nature Communications.

  • Immunotherapy and big data
    Antibody engineering
    Single cell multiomics

    Single-cell genomic approaches for developing the next generation of immunotherapies

    Yofe I., Dahan R. & Amit I. (2020) Nature Medicine.

  • Immunotherapy and big data

    PIK3CA in cancer: The past 30 years

    Arafeh R. & Samuels Y. (2019) Seminars in Cancer Biology.

  • Immunotherapy and big data

    Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities

    Sana G., Madigan J. P., Gartner J. J. et_al. (2019) Journal of Investigative Dermatology.

  • Immunotherapy and big data

    RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma

    Arafeh R., Di Pizio A., Elkahloun A. G., Dym O., Niv M. Y. & Samuels Y. (2019) Oncogene.

  • Immunotherapy and big data

    Global DNA methylation reflects spatial heterogeneity and molecular evolution of lung adenocarcinomas

    Dietz S., Lifshitz A., Kazdal D. et_al. (2019) International Journal of Cancer.

  • Immunotherapy and big data
    Single cell multiomics

    MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions

    Baran Y., Bercovich A., Sebe-Pedros A. et_al. (2019) GENOME BIOLOGY.

  • Single cell multiomics

    ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma

    Srivastava S., et al. (2019) Cell Reports.

  • Immunotherapy and big data

    UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

    Wolf Y., Bartok O., Patkar S. et_al. (2019) Cell.

  • Protein design

    A lipophilicity-based energy function for membrane-protein modelling and design

    Weinstein J. Y., Elazar A. & Fleishman S. J. (2019) PLoS Computational Biology.

  • Antibody engineering
    Protein design

    Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces

    Warszawski S., Katz A. B., Lipsh R. et_al. (2019) PLoS Computational Biology.

  • Single cell multiomics

    A niche-dependent myeloid transcriptome signature defines dormant myeloma cells

    Khoo W. H., et al. (2019) Blood.

  • Single cell multiomics

    MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing

    Keren-Shaul H., et al. (2019) Nature Protocols.

  • Immunotherapy and big data

    Cross-Talk between Receptor Tyrosine Kinases AXL and ERBB3 Regulates Invadopodia Formation in Melanoma Cells

    Revach O., Sandler O., Samuels Y. & Geiger B. (2019) Cancer research.

  • Immunotherapy and big data

    Long Noncoding RNA MALAT1 Regulates Cancer Glucose Metabolism by Enhancing mTOR-Mediated Translation of TCF7L2

    Malakar P., Stein I., Saragovi A., Winkler R., Stern-Ginossar N., Berger M., Pikarsky E. & Karni R. (2019) Cancer Research.

  • Antibody engineering
    Protein design

    AbPredict 2: a server for accurate and unstrained structure prediction of antibody variable domains

    Lapidoth G., Parker J., Prilusky J. & Fleishman S. J. (2019) Bioinformatics.

  • Single cell multiomics

    Cell composition analysis of bulk genomics using single-cell data

    Frishberg A., et al. (2019) Nature Methods.

  • Immunotherapy and big data
    Single cell multiomics

    Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

    Li H., van der Leun A. M., Yofe I., Lubling Y., et al. (2019) Cell.

  • Immunotherapy and big data
    Single cell multiomics

    Single-cell analysis illuminates the gradients of immune cell functional states within human melanoma tumors, and facilitates characterization of tumor-reactive T-cells

    Yofe I., et al. (2019) Cancer immunology research.

  • Antibody engineering

    Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor

    Shraga A., Olshvang E., Davidzohn N. et al. (2019) Cell Chemical Biology.

  • Immunotherapy and big data
    Single cell multiomics

    Cancer research in the era of immunogenomics

    Wolf Y. & Samuels Y. (2018) ESMO Open.

  • Protein design

    Ultrahigh specificity in a network of computationally designed protein-interaction pairs

    Netzer R., Listov D., Lipsh R., Dym O., Albeck S., Knop O., Kleanthous C. & Fleishman S. J. (2018) Nature Communications.

  • Immunotherapy and big data
    Single cell multiomics

    Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

    Ledergor G., Weiner A., Zada M. et_al. (2018) Nature Medicine.

  • Protein design

    Rapid characterization of secreted recombinant proteins by native mass spectrometry

    Ben-Nissan G., Vimer S., Warszawski S. et_al. (2018) Communications Biology.

  • Single cell multiomics

    Understanding the Cellular Origin and Pathogenic Transcriptional Programs in Multiple Myeloma (MM) and Light-Chain Amyloidosis (AL) through the Dissection of the Normal Plasma Cell (PC) Development

    Alameda D., et al. (2018) Blood.

  • Single cell multiomics

    Mytype: A Capture Based Sequencing Approach to Detect Somatic Mutations, Copy Number Changes and IGH Translocations in Multiple Myeloma

    Yellapantula V., et al. (2018) Blood.

  • Immunotherapy and big data

    Long Term AML Survivors Have Increased Mortality and High Prevalence of Clonal Hematopoiesis

    Ilani N. C., Niemeyer E., Cohen N. M. et_al. (2018) Blood.

  • Immunotherapy and big data
    Cell therapy

    Cancer exome-based identification of tumor neo-antigens using mass spectrometry

    Kalaora S. & Samuels Y. (2019) Cancer Immunosurveillance.

  • Immunotherapy and big data

    Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

    Kalaora S., Wolf Y., Feferman T. et_al. (2018) Cancer Discovery.

  • Single cell multiomics

    The Power of ONE: Immunology in the Age of Single Cell Genomics

    Amit I. (2019) Blood.

  • Immunotherapy and big data
    Single cell multiomics

    The Human Cell Atlas White Paper

    Regev A., et al. (2018) arXiv. 

  • Immunotherapy and big data
    Single cell multiomics

    Dissecting immune cell heterogeneity in human cancer by single-cell RNA-sequencing

    Yofe I., Li H., van der Leun A., Yaniv L., Weiner A., van Akkooi A., Tanay A., Schumacher T. & Amit I. (2018) Cancer immunology research.

  • Antibody engineering

    Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity

    Knorr D. A., Dahan R. & Ravetch J. (2018) Proceedings Of The National Academy Of Sciences.

  • Protein design

    Estimating Interprotein Pairwise Interaction Energies in Cell Lysates from a Single Native Mass Spectrum

    Cveticanin J., Netzer R., Arkind G., Fleishman S. J., Horovitz A. & Sharon M. (2018) Analytical Chemistry.

  • Immunotherapy and big data
    Single cell multiomics

    From the Human Cell Atlas to dynamic immune maps in human disease

    Adlung L. & Amit I. (2018) Nature Reviews Immunology.

  • Immunotherapy and big data

    CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma

    Alon M., Arafeh R., Lee J. S. et_al. (2018) Oncotarget.

  • Protein design

    A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen

    Amon R., Grant O. C., Ben-Arye S. L. et_al. (2018) Scientific Reports.

  • Immunotherapy and big data

    Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

    Martin D., Degese M. S., Vitale-Cross L. et_al. (2018) Nature Communications.

  • Immunotherapy and big data

    Prediction of acute myeloid leukemia risk in healthy individuals

    Abelson S., Collord G., Ng S. W. K. et_al. (2018) Nature.

  • Immunotherapy and big data

    Harnessing synthetic lethality to predict the response to cancer treatment

    Lee J. S., Das A., Jerby-Arnon L. et_al. (2018) Nature Communications.

  • Protein design

    Principles of Protein Stability and Their Application in Computational Design

    Goldenzweig A. & Fleishman S. J. (2018) Annual Review of Biochemistry.

  • Immunotherapy and big data

    Refinement of the endogenous epitope tagging technology allows the identification of a novel NRAS binding partner in melanoma

    Alon M., Emmanuel R., Qutob N., Bakhman A., Peshti V., Brodezki A., Bassan D., Kosloff M. & Samuels Y. (2018) Pigment Cell and Melanoma Research.

  • Immunotherapy and big data
    Cell therapy

    Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

    Yu Y., Schleich K., Yue B. et_al. (2018) Cancer Cell.

  • Immunotherapy and big data

    RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

    Qutob N., Masuho I., Alon M. et_al. (2018) Scientific Reports.

  • Single cell multiomics

    Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries

    Giladi A. & Amit I. (2018) Cell.

  • Immunotherapy and big data

    Analysis of enzymatic activity of matrix metalloproteinase (MMP) by collagen zymography in Melanoma

    Walia V. & Samuels Y. (2018) Proteases and Cancer.

  • Immunotherapy and big data

    Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells

    Arafeh R., Flores K., Keren-Paz A., Maik-Rachline G., Gutkind N., Rosenberg S., Seger R. & Samuels Y. (2017) Scientific Reports.

  • Immunotherapy and big data

    Genetic and Functional Analysis of GRIN2A in Tumor Samples

    Prickett T. D., Gartner J. J. & Samuels Y. (2017) NMDA Receptors.

  • Antibody engineering
    Protein design

    Principles for computational design of binding antibodies

    Baran D., Pszolla M. G., Lapidoth G. D., Norn C., Dym O., Unger T., Albeck S., Tyka M. D. & Fleishman S. J. (2017) Proceedings of the National Academy of Sciences.

  • Single cell multiomics

    Immunology, one cell at a time

    Giladi A. & Amit I. (2017) Nature.

  • Single cell multiomics

    Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

    Lavin Y., et al. (2017) Cell.

  • Antibody engineering
    Protein design

    Improved antibody-based ricin neutralization by affinity maturation is correlated with slower off-rate values

    Rosenfeld R., Alcalay R., Mechaly A., Lapidoth G., Epstein E., Kronman C., Fleishman S. J. & Mazor O. (2017) Protein Engineering, Design and Selection.

  • Immunotherapy and big data

    Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome

    Schwartzman O., Savino A. M., Gombert M. et_al. (2017) Proceedings Of The National Academy Of Sciences.

  • Single cell multiomics

    Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression

    Fiziev P., et al. (2017) Cell Reports.

  • Antibody engineering

    Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

    Vargas F. A., Furness A. J. S., Solomon I. et al. (2017) Immunity.

  • Antibody engineering

    Signaling by Antibodies: Recent Progress

    Bournazos S., Wang T. T., Dahan R., Maamary J. & Ravetch J. V. (2017) ANNUAL REVIEW OF IMMUNOLOGY.

  • Antibody engineering
    Protein design

    Incorporating an allosteric regulatory site in an antibody through backbone design

    Khersonsky O. & Fleishman S. J. (2017) Protein Science.

  • Immunotherapy and big data
    Single cell multiomics

    Scaling single-cell genomics from phenomenology to mechanism

    Tanay A. & Regev A. (2017) Nature.

  • Single cell multiomics

    Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

    Jaitin D. A., Weiner A., Yofe I. et_al. (2016) Cell.

  • Antibody engineering
    Protein design

    High-accuracy modeling of antibody structures by a search for minimum-energy recombination of backbone fragments

    Norn C. H., Lapidoth G. & Fleishman S. J. (2017) Proteins-Structure Function And Bioinformatics.

  • Antibody engineering

    Co-targeting of Adenosine Signaling Pathways for Immunotherapy: Potentiation by Fc Receptor Engagement

    Dahan R. & Ravetch J. V. (2016) Cancer Cell.

  • Immunotherapy and big data

    Parkin Somatic Mutations Link Melanoma and Parkinson's Disease

    Levin L., Srour S., Gartner J. et_al. (2016) Journal of Genetics and Genomics.

  • Antibody engineering

    Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective Fc gamma R Engagement

    Dahan R., Barnhart B. C., Li F., Yamniuk A. P., Korman A. J. & Ravetch J. V. (2016) Cancer Cell.

  • Antibody engineering

    Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

    Georgoudaki A., Prokopec K. E., Boura V. F. et al. (2016) Cell Reports.

  • Protein design

    Inspired by nature

    Netzer R. & Fleishman S. J. (2016) Science.

  • Immunotherapy and big data

    The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells

    Revach O., Winograd-Katz S. E., Samuels Y. & Geiger B. (2016) Experimental Cell Research.

  • Protein design

    Why reinvent the wheel? Building new proteins based on ready-made parts

    Khersonsky O. & Fleishman S. J. (2016) Protein Science.

  • Antibody engineering
    Protein design

    Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma

    Grossman I., Ilani T., Fleishman S. & Fass D. (2016) Protein engineering, design & selection : PEDS.

  • Immunotherapy and big data

    Use of HLA peptidomics and whole exome sequencing to identify human immunogenic neo-antigens

    Kalaora S., Barnea E., Merhavi-Shoham E. et_al. (2016) Oncotarget.

  • Immunotherapy and big data

    Recurrent inactivating RASA2 mutations in melanoma

    Arafeh R., Qutob N., Emmanuel R. et_al. (2015) Nature Genetics. 

  • Immunotherapy and big data
    Single cell multiomics

    Single-cell epigenomics: techniques and emerging applications

    Schwartzman O. & Tanay A. (2015) Nature Reviews Genetics.

  • Antibody engineering

    Fc gamma Rs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis

    Dahan R., Sega E., Engelhardt J., Selby M., Korman A. J. & Ravetch J. V. (2015) Cancer Cell.

  • Immunotherapy and big data
    Single cell multiomics

    From mass cytometry to cancer prognosis

    Winter D. R., Ledergor G. & Amit I. (2015) Nature Biotechnology. 

  • Immunotherapy and big data

    The functional relevance of somatic synonymous mutations in melanoma and other cancers

    Gotea V., Gartner J. J., Qutob N., Elnitski L. & Samuels Y. (2015) Pigment Cell and Melanoma Research. 

  • Protein design

    Editorial overview: Protein design and evolution-new protein architectures, evolutionary fine-tuning and analysis

    Fleishman S. J. & Pluckthun A. (2015) Current Opinion in Structural Biology.

  • Antibody engineering

    T cell help controls the speed of the cell cycle in germinal center B cells

    Gitlin A. D., Mayer C. T., Oliveira T. Y., Shulman Z., Jones M. J. K., Koren A. & Nussenzweig M. C. (2015) Science.

  • Immunotherapy and big data

    Genomic Classification of Cutaneous Melanoma

    The Cancer Genome Atlas Network. (2015) Cell.

  • Immunotherapy and big data

    Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation

    Kim H., Frederick D., Levesque M. et_al. (2015) Cell Reports.

  • Immunotherapy and big data

    YAP and the drug resistance highway

    Keren-Paz A., Emmanuel R. & Samuels Y. (2015) Nature Genetics.

  • Protein design

    AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences

    Lapidoth G., Baran D., Pszolla G., Norn C., Alon A., Tyka M. & Fleishman S. (2015) Proteins-Structure Function And Bioinformatics.

  • Immunotherapy and big data

    Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

    Ben Chetrit C. N., Chetrit D., Russell R. et al. (2015) Science Signaling.