Fast multimodal imaging of brain dynamics underlying sleep and wakefulness
Date:
Lecture / Seminar
Time: 14:00-15:00
Title: On ZOOM
Lecturer: Dr. Laura Lewis
Organizer: Department of Brain Sciences
Details: Center for Systems Neuroscience
Boston University
Abstract: When we fall asleep, brain function and physiology are rapidly transformed. Unde ... Read more When we fall asleep, brain function and physiology are rapidly transformed. Understanding the neural basis of sleep requires imaging methods that can capture multiple aspects of brain physiology at fast timescales. We develop approaches for analyzing human brain physiology using multimodal neuroimaging, and apply them to investigate the neural origins and consequences of sleep. We found that accelerated methods for fMRI can enable imaging subsecond neural dynamics throughout the human brain. We applied these methods to investigate the neural dynamics that occur at state transitions, and identified temporal sequences within thalamocortical networks that precede the moment of awakening from sleep. In addition, we developed a method to image cerebrospinal fluid flow, and discovered large waves of fluid flow that appear in the sleeping human brain. Together, these studies highlight the new biological information that can be extracted from fast fMRI data, and use this approach to discover neurophysiological dynamics unique to the sleeping brain.
Link: https://weizmann.zoom.us/j/95406893197?pwd=REt5L1g3SmprMUhrK3dpUDJVeHlrZz09
Meeting ID: 954 0689 3197
Password: 750421
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