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    Sagol Longevity Series

    Date:
    19
    Thursday
    June
    2025
    Lecture / Seminar
    Time: 00:00
    Location: Arthur and Rochelle Belfer Building for Biomedical Research
    Lecturer: Library Help
    Organizer: Sagol Institute for Longevity Research
    Contact: urialonw@gmail.com

    Sagol Longevity Series

    Date:
    22
    Thursday
    May
    2025
    Lecture / Seminar
    Time: 00:00
    Location: Arthur and Rochelle Belfer Building for Biomedical Research
    Lecturer: TBD
    Organizer: Sagol Institute for Longevity Research
    Contact: urialonw@gmail.com

    Vascular Aging:

    Date:
    18
    Tuesday
    March
    2025
    Lecture / Seminar
    Time: 11:00-12:00
    Title: The Hidden Driver of Age-Related Organ Dysfunction
    Location: Arthur and Rochelle Belfer Building for Biomedical Research
    Lecturer: Dr. Myriam Grunewald
    Organizer: Sagol Institute for Longevity Research
    Contact: urialonw@gmail.com
    Abstract: As life expectancy increases, age-related diseases are becoming more prevalent. ... Read more As life expectancy increases, age-related diseases are becoming more prevalent. While these conditions are traditionally studied in isolation, mounting evidence points to shared, systemic mechanisms underlying these conditions. Our research highlights the vasculature as  a key player in organ homeostasis and repair, and a system shared across all organs—making its dysfunction potential driver of age-related pathologies.We demonstrate that manipulating VEGF signaling to counteract age-related microvascular rarefaction promotes comprehensive geroprotection, preserving organ function and delaying disease onset. Our findings also reveal a link between vascular rarefaction and altered RNA splicing. While hypoxia-driven and age-related changes in alternative RNA splicing have been studied independently, we propose a unifying mechanism that links the two. To explore this further, we also employ patient-derived organoids, which retain their biological age in culture, providing a robust in vitro platform to test anti-aging interventions.Our findings support a vascular theory of aging, identifying vascular health as a promising target to mitigate age-related diseases and promote healthier aging.
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    Sagol Longevity Series

    Date:
    18
    Tuesday
    February
    2025
    Lecture / Seminar
    Time: 11:00-12:00
    Location: Arthur and Rochelle Belfer Building for Biomedical Research
    Lecturer: TBD
    Organizer: Sagol Institute for Longevity Research
    Contact: urialonw@gmail.com

    Sagol Longevity Series

    Date:
    22
    Wednesday
    January
    2025
    Lecture / Seminar
    Time: 11:00-12:00
    Location: Arthur and Rochelle Belfer Building for Biomedical Research
    Lecturer: Prof. Haim Cohen
    Organizer: Sagol Institute for Longevity Research
    Contact: urialonw@gmail.com

    "Though the city used to be called Luz" –SIRT6, aging and beyond.

    Date:
    22
    Wednesday
    January
    2025
    Lecture / Seminar
    Time: 11:00-12:00
    Title: The mammalian longevity associated acetylome
    Location: Arthur and Rochelle Belfer Building for Biomedical Research
    Lecturer: Dr. Haim Cohen
    Organizer: Sagol Institute for Longevity Research
    Contact: urialonw@gmail.com
    Abstract: Despite extensive studies at the genomic, transcriptomic, and metabolomic levels ... Read more Despite extensive studies at the genomic, transcriptomic, and metabolomic levels, the underlying mechanisms regulating longevity remain incompletely understood. Post-translational protein acetylation has been suggested to regulate aspects of longevity. To further explore the role of acetylation, we developed the PHARAOH computational tool, based on the 100-fold differences in longevity within the mammalian class. Analyzing acetylome and proteome data across 107 mammalian species identified multiple significant longevity-associated acetylated lysine residues in mice and humans, controlling many longevity-related pathways. Specifically, we found that longevity-associated acetylation sites help resolve the Peto Paradox: the enigma of why animals with increased body size live longer yet do not exhibit much higher cancer incidence. Our findings show a significant positive correlation between these new acetylation sites and protection against multiple types of cancer in humans. Moreover, mutating these sites reduced the anti-neoplastic functions of the acetylated proteins. These findings provide new insights into the pivotal role of protein acetylation in mammalian longevity, suggesting potential interventions to extend human healthspan.
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