Genomic and functional approaches to modeling and targeting cancer aneuploidy announced

Date:
30
Thursday
January
2025
Lecture / Seminar
Time: 15:00-16:00
Location: Nella and Leon Benoziyo Building for Biological Sciences
Lecturer: Prof. Uri Ben-David,Prof. Uri Ben-David
Organizer: Department of Biomolecular Sciences
Contact: levana.ayvazo@weizmann.ac.il
Details: Dept of Human Molecular Genetics & Biochemistry, Faculty of Medicine, Tel-Av ... Read more Dept of Human Molecular Genetics & Biochemistry, Faculty of Medicine, Tel-Aviv University
Close details
Abstract: Aneuploidy, an imbalanced number of chromosomes or chromosome arms, is a genetic ... Read more Aneuploidy, an imbalanced number of chromosomes or chromosome arms, is a genetic hallmark of cancer cells, yet aneuploidy remains a biological enigma and a missed opportunity for cancer therapy. My lab applies experimental and computational approaches to dissect the basic biology underlying cancer aneuploidy and to study its cellular consequences. In this seminar, I will focus on an unpublished study in which we discovered an important role for a recurrent aneuploidy in driving brain metastasis, revealed the underlying molecular mechanism, and identified a therapeutically-relevant cellular vulnerability that is associated with this common aneuploidy.
Close abstract