Mechanisms of axonal degeneration following traumatic brain injury

Date:
19
Monday
May
2025
Lecture / Seminar
Time: 11:00-12:30
Location: Benoziyo Bldg. for Biological Sciences
Lecturer: Prof. Wilma Friedman
Details: Special Guest Joint Seminar Dept. of Biomolecular Sciences & Dept. of&n ... Read more Special Guest Joint Seminar Dept. of Biomolecular Sciences & Dept. of  Molecular Neuroscience
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Abstract: Traumatic brain injury to the cortex elicits the loss of neurons at the site of ... Read more Traumatic brain injury to the cortex elicits the loss of neurons at the site of damage, but also evokes changes in the tissue environment of axon terminals that project to the site of injury from distal locations.  We previously demonstrated that basal forebrain cholinergic neurons (BFCNs) undergo retrograde degeneration following cortical TBI that is mediated by the p75 neurotrophin receptor (p75NTR).  We have investigated mechanisms governing p75NTR-mediated retrograde degeneration as well as the behavioral consequences of the loss of BFCNs following TBI.  Mice lacking the p75NTR in cholinergic neurons showed sparing of these neurons following TBI, and preservation of cognitive function.
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