From the lab to the clinic: A toolbox for single-molecule epigenetic analysis of DNA

Date:
18
Tuesday
June
2024
Lecture / Seminar
Time: 10:00-11:00
Location: Nella and Leon Benoziyo Building for Biological Sciences
Lecturer: Prof. Yuval Ebenstein
Organizer: Department of Biomolecular Sciences
Contact: levana.ayvazo@weizmann.ac.il
Details: Department of Physical Chemistry Tel-Aviv University
Abstract: Short-read DNA sequencing (NGS) is revolutionizing all fields of biological rese ... Read more Short-read DNA sequencing (NGS) is revolutionizing all fields of biological research. Still, it fails to extract the full range of information associated with genetic material and cannot resolve many variations between genomes. The information content of the genome extends beyond the base sequence in the form of chemical modifications such as DNA methylation, damage lesions, or chromosomal association with DNA-binding proteins (chromatin). For the last decade, our lab has been developing tools for genomic analysis at the single-cell and single-molecule levels. I’ll present a biochemical and physical toolbox for mapping epigenetic modifications in the genome and demonstrate its application in clinical cancer research.
Close abstract