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Dynamic lipid aptamers: non-polymeric chemical path to early life
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Prediction of Childhood Obesity from Nationwide Health Records
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The long-term genetic stability and individual specificity of the human gut microbiome
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Unified platform for genetic and serological detection of COVID-19 with single-molecule technology
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Large-scale association analyses identify host factors influencing human gut microbiome composition
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Genome-wide association study identifies 16 genomic regions associated with circulating cytokines at birth
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A reference map of potential determinants for the human serum metabolome
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Building an international consortium for tracking coronavirus health status
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Axes of a revolution: challenges and promises of big data in healthcare
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A framework for identifying regional outbreak and spread of COVID-19 from one-minute population-wide surveys
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The human tumor microbiome is composed of tumor type-specific intracellular bacteria
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Rare Variant Burden Analysis within Enhancers Identifies CAV1 as an ALS Risk Gene
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Author Correction: Introducing PIONEER: a project to harness big data in prostate cancer research (Nature Reviews Urology, (2020), 17, 6, (351-362), 10.1038/s41585-020-0324-x)
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Visualizing the structure and motion of the long noncoding RNA HOTAIR
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Introducing PIONEER: a project to harness big data in prostate cancer research
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The road ahead in genetics and genomics
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A unified nomenclature for vertebrate olfactory receptors
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Gene Architecture and Sequence Composition Underpin Selective Dependency of Nuclear Export of Long RNAs on NXF1 and the TREX Complex
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Non-lethal message from the Holy Land: The first international conference on nonapoptotic roles of apoptotic proteins
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Identifying gut microbes that affect human health
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Clinically Accurate Prediction of Glucose Levels in Patients with Type 1 Diabetes
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Prediction of gestational diabetes based on nationwide electronic health records
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Rich data sets could end costly drug discovery
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Longitudinal symptom dynamics of COVID-19 infection
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A new MEIOB mutation is a recurrent cause for azoospermia and testicular meiotic arrest
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Twenty Years of "Lipid World": A Fertile Partnership with David Deamer
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Genome analysis and knowledge-driven variant interpretation with TGex
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The rationale and design of the personal diet study, a randomized clinical trial evaluating a personalized approach to weight loss in individuals with pre-diabetes and early-stage type 2 diabetes
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Regularization learning networks: Deep learning for tabular datasets
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International conference on Cell Death in Cancer and Toxicology 2018 (CDCT-2018)
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The Helix Twist: Damage and Repair Follows the DNA Minor Groove
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Mutations in AIFM1 cause an X-linked childhood cerebellar ataxia partially responsive to riboflavin
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A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation
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The landscape of sex-differential transcriptome and its consequent selection in human adults
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p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis
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Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activity
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Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration
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Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect
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The GeneCards suite: From gene data mining to disease genome sequence analyses
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A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
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Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations
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The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
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Identification of a Functional Risk Variant for Pemphigus Vulgaris in the ST18 Gene
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PLoS Genetics. 12, 5, e1006008
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The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila
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VarElect: The phenotype-based variation prioritizer of the GeneCards Suite
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Toward a systematic understanding of translational regulatory elements in human and viruses
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Genic insights from integrated human proteomics in GeneCards.
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An extended cyclic di-GMP network in the predatory bacterium Bdellovibrio bacteriovorus
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Integrated identification of disease-gene links and their utility in next-generation sequencing interpretation
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The human olfactory transcriptome
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BMC Genomics. 17, 1, 619
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ORDB, HORDE, ODORactor and other on-line knowledge resources of olfactory receptor-odorant interactions
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Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides
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A minimalistic resource allocation model to explain ubiquitous increase in protein expression with growth rate
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Massively Parallel Interrogation of the Effects of Gene Expression Levels on Fitness
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Integrative genomic analysis by interoperation of bioinformatics tools in GenomeSpace
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Comparative genetics: Systematic discovery of cap-independent translation sequences in human and viral genomes
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Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples
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Whole-exome sequencing in undiagnosed genetic diseases: Interpreting 119 trios
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Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling
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Exome sequencing as a differential diagnosis tool: Resolving mild trichohepatoenteric syndrome
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Noise in gene expression is coupled to growth rate
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A day in the life of the meta-organism: Diurnal rhythms of the intestinal microbiome and its host
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PathCards: Multi-source consolidation of human biological pathways
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Cell-cycle progress in obligate predatory bacteria is dependent upon sequential sensing of prey recognition and prey quality cues
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Personalized Nutrition by Prediction of Glycemic Responses
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Non-caloric artificial sweeteners and the microbiome: Findings and challenges
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Systematic Dissection of the Sequence Determinants of Gene 3 End Mediated Expression Control
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Core promoter sequence in yeast is a major determinant of expression level
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Absence of α-and β-dystroglycan is associated with Walker-Warburg syndrome
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GenoExp: A web tool for predicting gene expression levels from single nucleotide polymorphisms
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Editorial overview: Genome architecture and expression
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Unraveling determinants of transcription factor binding outside the core binding site
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Genome Research. 25, 7, p. 1018-1029
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Artificial Sweeteners Induce Glucose Intolerance by Altering the Gut Microbiota: Editorial comment
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Artificial sweeteners induce glucose intolerance by altering the gut microbiota
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A shared architecture for promoters and enhancers
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MOPED enables discoveries through consistently processed proteomics data
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In pursuit of design principles of regulatory sequences
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Host-parasite network structure is associated with community-level immunogenetic diversity
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Paternal mitochondrial destruction after fertilization is mediated by a common endocytic and autophagic pathway in drosophila
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Probing the effect of promoters on noise in gene expression using thousands of designed sequences
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The grammar of transcriptional regulation
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Reduced selection and accumulation of deleterious mutations in genes exclusively expressed in men
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An atypical naturally split intein engineered for highly efficient protein labeling
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Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis
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Multispecies population dynamics of prebiotic compositional assemblies
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Molecular dissection of the genetic mechanisms that underlie expression conservation in orthologous yeast ribosomal promoters
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In and out: an analysis of epibiotic vs periplasmic bacterial predators
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MalaCards: A Comprehensive automatically-mined Database of human diseases
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Landscape and variation of RNA secondary structure across the human transcriptome
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Quasispecies in population of compositional assemblies
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Alternative germ cell death pathway in drosophila involves HtrA2/Omi, lysosomes, and a caspase-9 counterpart
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Determinants of nucleosome positioning
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Non-redundant compendium of human ncRNA genes in GeneCards
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An overview of synergistic data tools for biological scrutiny
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General Olfactory Sensitivity Database (GOSdb): Candidate Genes and their Genomic Variations
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TECPR2:A new autophagy link for neurodegeneration
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Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise
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The MATCHIT automaton: Exploiting compartmentalization for the synthesis of branched polymers
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Measurements of the Impact of 3 End Sequences on Gene Expression Reveal Wide Range and Sequence Dependent Effects
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Promoters maintain their relative activity levels under different growth conditions
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Nucleosome maps of the human cytomegalovirus genome reveal a temporal switch in chromatin organization linked to a major IE protein
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MalaCards: An integrated compendium for diseases and their annotation
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Deficiency of Asparagine Synthetase Causes Congenital Microcephaly and a Progressive Form of Encephalopathy
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Robust Prediction of Expression Differences among Human Individuals Using Only Genotype Information
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Predicting Disease Risk Using Bootstrap Ranking and Classification Algorithms
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Deciphering the rules by which 5'-UTR sequences affect protein expression in yeast
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Fixated on fixation - using ChIP to interrogate the dynamics of chromatin interactions
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Oriented covalent immobilization of antibodies for measurement of intermolecular binding forces between zipper-like contact surfaces of split inteins
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HORDE: Comprehensive resource for olfactory receptor genomics
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Sequence features of yeast and human core promoters that are predictive of maximal promoter activity
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By their genes ye shall know them: Genomic signatures of predatory bacteria
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Inferring gene expression from ribosomal promoter sequences, a crowdsourcing approach
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Mutation in TECPR2 reveals a role for autophagy in hereditary spastic paraparesis
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Is There an Optimal Level of Open-Endedness in Prebiotic Evolution?
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New insights into replication origin characteristics in metazoans
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Sporoptosis: Sowing the Seeds of Nuclear Destruction
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Association of the type 2 diabetes mellitus susceptibility gene, TCF7L2, with schizophrenia in an Arab-Israeli family sample
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Personal receptor repertoires: olfaction as a model
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Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters
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Cell lineage analysis of the mammalian female germline
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Genome-wide Measurement of RNA Folding Energies
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DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population
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Genome sequence of the pattern-forming social bacterium: Paenibacillus dendritiformis C454 Chiral Morphotype
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Caspase levels and execution efficiencies determine the apoptotic potential of the cell
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MOPED: Model Organism Protein Expression Database
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Evolutionary grass roots for odor recognition
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Manipulating nucleosome disfavoring sequences allows fine-tune regulation of gene expression in yeast
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Excess Mutual Catalysis Is Required for Effective Evolvability
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The NAB-Brk signal bifurcates at JNK to independently induce apoptosis and compensatory proliferation
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There Is More to Life than Death: A Moonlighting Function of a Bcl-2 Member
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High nucleosome occupancy is encoded at X-linked gene promoters in C. elegans
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In-silico human genomics with GeneCards
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New modularity of DAP-kinases: Alternative splicing of the DRP-1 gene produces a Zipk-like isoform
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Replication of simulated prebiotic amphiphile vesicles controlled by experimental lipid physicochemical properties
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Computational Prediction of RNA Structural Motifs Involved in Post-Transcriptional Regulatory Processes
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Mapping of molecular pathways, biomarkers and drug targets for diabetic nephropathy
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Synthetic lethal hubs associated with vincristine resistant neuroblastoma
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Myosin drives autophagy in a pathway linking Atg1 to Atg9
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Understanding the transcriptome through RNA structure
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Activity, specificity and structure of I-Bth0305I: A representative of a new homing endonuclease family
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Identification of plant RAD52 homologs and characterization of the arabidopsis thaliana RAD52-like genes
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Atg8: An autophagy-related ubiquitin-like protein family
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Distinct molecular regulation of glycogen synthase kinase-3α isozyme controlled by its N-terminal region functional role in CALCIUM/CALPAIN signaling
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Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation
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Omics Data Management and Annotation
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How Transcription Factors Identify Regulatory Sites in Genomic Sequence
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Identification of new schizophrenia susceptibility loci in an ethnically homogeneous, family-based, Arab-Israeli sample
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Alkelai A., Lupoli S., Greenbaum L., Giegling I., Kohn Y., Sarner-Kanyas K., Ben-Asher E., Lancet D., Rujescu D., Macciardi F. & Lerer B. (2011),
FASEB Journal. 25, 11, p. 4011-4023
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Axonal degeneration is regulated by the apoptotic machinery or a NAD +-sensitive pathway in insects and mammals
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Spontaneous chiral symmetry breaking in early molecular networks
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Long noncoding RNA as modular scaffold of histone modification complexes
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Science. 329, 5992, p. 689-693
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A novel F-box protein is required for caspase activation during cellular remodeling in Drosophila
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Substrate Competitive GSK-3 Inhibitors {single bond} strategy and Implications
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Gradients of a Ubiquitin E3 Ligase Inhibitor and a Caspase Inhibitor Determine Differentiation or Death in Spermatids
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Lymphoblast and brain expression of AHI1 and the novel primate-specific gene, C6orf217, in schizophrenia and bipolar disorder
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Nucleosome sequence preferences influence in vivo nucleosome organization
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Kaplan N., Moore I., Fondufe-Mittendorf Y., Gossett A. J., Tillo D., Field Y., Hughes T. R., Lieb J. D., Widom J. & Segal E. (2010),
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Contribution of histone sequence preferences to nucleosome organization: Proposed definitions and methodology
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Meig1 deficiency causes a severe defect in mouse spermatogenesis
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Fine mapping of AHI1 as a schizophrenia susceptibility gene: From association to evolutionary evidence
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Torri F., Akelai A., Lupoli S., Sironi M., Amann Zalcenstein D., Fumagalli M., Dal Fiume C., Ben-Asher E., Kanyas K., Cagliani R., Cozzi P., Trombetti G., Lievers L. S., Salvi E., Orro A., Beckmann J. S., Lancet D., Kohn Y. & Milanesi L. (2010),
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GeneCards Version 3: the human gene integrator.
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Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project
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Replication and darwinian selection define life's origin
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Markovitch O., Inger A., Shenhav B. & Lancet D. (2010), Origins of Life and Evolution of Biospheres. 40, 4, p. 484-488
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Systematic inference of copy-number genotypes from personal genome sequencing data reveals extensive olfactory receptor gene content diversity
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Overlapping codes within protein-coding sequences
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Genome sequence of the pattern forming Paenibacillus vortex bacterium reveals potential for thriving in complex environments
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Mutation detection with next-generation resequencing through a mediator genome
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p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancy
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Genome-wide measurement of RNA secondary structure in yeast
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Widespread compensatory evolution conserves DNA-encoded nucleosome organization in yeast
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Splicing of the mycobacteriophage bethlehem DnaB intein: Identification of a new mechanistic class of inteins that contain an obligate block f nucleophile
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High nucleosome occupancy is encoded at human regulatory sequences
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The DNA-encoded nucleosome organization of a eukaryotic genome
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Kaplan N., Moore I. K., Fondufe-Mittendorf Y., Gossett A. J., Tillo D., Field Y., LeProust E. M., Hughes T. R., Lieb J. D., Widom J. & Segal E. (2009),
Nature. 458, 7236, p. 362-366
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Proteome-wide prediction of acetylation substrates
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Proceedings of the National Academy of Sciences of the United States of America. 106, 33, p. 13785-13790
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GeneDecks: Paralog hunting and gene-set distillation with genecards annotation
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Drosophila Past1 is involved in endocytosis and is required for germline development and survival of the adult fly
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Olswang-Kutz Y., Gertel Y., Benjamin S., Sela O., Pekar O., Arama E., Steller H., Horowitz M. & Segal D. (2009),
Journal of Cell Science. 122, 4, p. 471-480
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Common peptides shed light on evolution of Olfactory Receptors
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Fractured genes: A novel genomic arrangement involving new split inteins and a new homing endonuclease family
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Poly(dA:dT) tracts: major determinants of nucleosome organization
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GIFtS: Annotation landscape analysis with GeneCards
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Human olfaction: from genomic variation to phenotypic diversity
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Mutations and lethality in simulated prebiotic networks
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Gene expression divergence in yeast is coupled to evolution of DNA-encoded nucleosome organization
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Incorporating nucleosomes into thermodynamic models of transcription regulation
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Evidence for an interaction of schizophrenia susceptibility loci on chromosome 6q23.3 and 10q24.33-q26.13 in Arab Israeli families
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Alkelai A., Kohn Y., Olender T., Sarner-Kanyas K., Rigbi A., Hamdan A., Ben-Asher E., Lancet D. & Lerer B. (2009),
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Can't live without them, can live with them: Roles of caspases during vital cellular processes
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Further evidence for association of the RGS2 gene with antipsychotic-induced parkinsonism: Protective role of a functional polymorphism in the 3-untranslated region
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From DNA sequence to transcriptional behaviour: A quantitative approach
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What controls nucleosome positions?
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Bacterial intein-like domains of predatory bacteria: A new domain type characterized in Bdellovibrio bacteriovorus
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Erratum: Drosophila Past1 is involved in endocytosis and is required for germline development and survival of the adult fly (Journal of Cell Science (2009) vol. 122 (1929) 10.1242/jcs.054080)
Authors:
Olswang-Kutz Y., Gertel Y., Benjamin S., Sela O., Pekar O., Arama E., Steller H., Horowitz M. & Segal D. (2009),
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Geometric constraints on neuronal connectivity facilitate a concise synaptic adhesive code
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Genome analysis of the platypus reveals unique signatures of evolution (Nature (2008) 453, (175-183))
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High-resolution copy-number variation map reflects human olfactory receptor diversity and evolution
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Hasin Y., Olender T., Khen M., Gonzaga-Jauregui C., Kim P. M., Urban A. E., Snyder M., Gerstein M. B., Lancet D. & Korbel J. O. (2008),
PLoS Genetics. 4, 11, e1000249
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Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation
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Proteome-Based Comparative Analyses of Growth Stages Reveal New Cell Cycle-Dependent Functions in the Predatory Bacterium Bdellovibrio bacteriovorus
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Reconstruction of Cell Lineage Trees in Mice
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Wasserstrom A., Adar R., Shefer G., Frumkin D., Itzkovitz S., Stern T., Shur I., Zangi L., Kaplan S., Harmelin A., Reisner Y., Benayahu D., Tzahor E., Segal E. & Shapiro E. (2008),
PLoS ONE. 3, 4, 1939
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Preferentially Quantized Linker DNA Lengths in Saccharomyces cerevisiae
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Predicting expression patterns from regulatory sequence in Drosophila segmentation
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A feature-based approach to modeling protein-DNA interactions
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Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells
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New Insights into the Autoinhibition Mechanism of Glycogen Synthase Kinase-3β
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Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function
Authors:
Rigbi A., Kanyas K., Yakir A., Greenbaum L., Pollak Y., Ben-Asher E., Lancet D., Kertzman S. & Lerer B. (2008),
Genes Brain And Behavior. 7, 2, p. 164-172
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Using expression profiles of Caenorhabditis elegans neurons to identify genes that mediate synaptic connectivity
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Distinct modes of regulation by chromatin encoded through nucleosome positioning signals
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Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells
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Revealing targeted therapy for human cancer by gene module maps
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Systematic functional characterization of cis-regulatory motifs in human core promoters
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Reversal of aging by NFκB blockade
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Genome-wide linkage scan, fine mapping, and haplotype analysis in a large, inbred, Arab Israeli pedigree suggest a schizophrenia susceptibility locus on chromosome 20p13
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Teltsh O., Kanyas K., Karni O., Levi A., Korner M., Ben-Asher E., Lancet D., Hamdan A., Lerer B. & Kohn Y. (2008),
American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics. 147B, 2, p. 209-215
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Computational prediction of RNA structural motifs involved in posttranscriptional regulatory processes
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Update on the olfactory receptor (OR) gene superfamily.
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A multi-scaled approach to artificial life simulation with P Systems and Dissipative Particle Dynamics
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Stemness, cancer and cancer stem cells
Authors:
Wong D. J., Segal E. & Chang H. Y. (2008),
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Estimating cell depth from somatic mutations
Authors:
Wasserstrom A., Frumkin D., Adar R., Itzkovitz S., Stern T., Kaplan S., Shefer G., Shur I., Zangi L., Reizel Y., Harmelin A., Dor Y., Dekel N., Reisner Y., Benayahu D., Tzahor E., Segal E. & Shapiro E. (2008),
PLoS Computational Biology. 4, 5, 1000058
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Novel definition files for human GeneChips based on GeneAnnot
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Ferrari F., Bortoluzzi S., Coppe A., Sirota A., Safran M., Shmoish M., Ferrari S., Lancet D., Danieli G. A. & Bicciato S. (2007),
BMC Bioinformatics. 8, 446
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Association of the dopamine receptor interacting protein gene, NEF3, with early response to antipsychotic medication
Authors:
Strous R. D., Greenbaum L., Kanyas K., Merbl Y., Horowitz A., Karni O., Viglin D., Olender T., Deshpande S. N., Lancet D., Ben-Asher E. & Lerer B. (2007),
International Journal of Neuropsychopharmacology. 10, 3, p. 321-333
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Coevolution of compositional protocells and their environment
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A feature-based approach to modeling protein-DNA interactions
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Sharon E. & Segal E. (2007), RESEARCH IN COMPUTATIONAL MOLECULAR BIOLOGY, PROCEEDINGS. 4453, p. 77-91
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Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers
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Grossman I., Avidan N., Singer C., Goldstaub D., Hayardeny L., Eyal E., Ben-Asher E., Paperna T., Pe'er I., Lancet D., Beckmann J. S. & Miller A. (2007),
Pharmacogenetics and Genomics. 17, 8, p. 657-666
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Haplotype structure and selection of the MDM2 oncogene in humans
Authors:
Atwal G. S., Bond G. L., Metsuyanim S., Papa M., Friedman E., Distelman-Menachem T., Ben-Asher E., Lancet D., Ross D. A., Sninsky J., White T. J., Levine A. J. & Yarden R. (2007),
Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4524-4529
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Mutations in olfactory signal transduction genes are not a major cause of human congenital general anosmia
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A module of negative feedback regulators defines growth factor signaling
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Amit I., Citri A., Shay T., Lu Y., Katz M., Zhang F., Tarcic G., Siwak D., Lahad J., Jacob-Hirsch J., Amariglio N., Vaisman N., Segal E., Rechavi G., Alon U., Mills G. B., Domany E. & Yarden Y. (2007),
Nature Genetics. 39, 4, p. 503-512
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Trans protein splicing of cyanobacterial split inteins in endogenous and exogenous combinations
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A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila
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Erratum: AHI1, a pivotal neurodevelopment gene, and C6orf217 are associated with susceptibility to schizophrenia (European Journal of Human Genetics (2006) vol. 14 (1111-1119) 10.1038/sj.ejhg.5201675)
Authors:
Amann-Zalcenstein D., Avidan N., Kanyas K., Ebstein R. P., Kohn Y., Hamdan A., Ben-Asher E., Karni O., Mujaheed M., Segman R. H., Maier W., Macciardi F., Beckmann J. S., Lancet D. & Lerer B. (2007),
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The role of site accessibility in microRNA target recognition
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Rapid assessment of correlated amino acids from pair-to-pair (P2P) substitution matrices
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The Drosophila caspases strica and dronc function redundantly in programmed cell death during oogenesis
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Search for hand osteoarthritis susceptibility locus on chromosome 6p12.3-p12.1
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Genetic elucidation of human hyperosmia to isovaleric acid
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Occurrence of protein structure elements in conserved sequence regions
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Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
Authors:
Rinn J. L., Kertesz M., Wang J. K., Squazzo S. L., Xu X., Brugmann S. A., Goodnough L. H., Helms J. A., Farnham P. J., Segal E. & Chang H. Y. (2007),
Cell. 129, 7, p. 1311-1323
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Zinc-ion binding and cytokine activity regulation pathways predicts outcome in relapsing-remitting multiple sclerosis
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Refining intra-protein contact prediction by graph analysis
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A transcriptional program mediating entry into cellular quiescence
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A pair-to-pair amino acids substitution matrix and its applications for protein structure prediction
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InSite: A computational method for identifying protein-protein interaction binding sites on a proteome-wide scale
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Question 7: The first units of life were not simple cells
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Molecular Recognition in Biology: Models for Analysis of Protein-Ligand Interactions
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Decoding global gene expression programs in liver cancer by noninvasive imaging
Authors:
Segal E., Sirlin C. B., Ooi C., Adler A. S., Gollub J., Chen X., Chan B. K., Matcuk G. R., Barry C. T., Chang H. Y. & Kuo M. D. (2007),
Nature biotechnology. 25, 6, p. 675-680
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Erratum: Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates (PLoS Biology (2007) 2, 1, DOI: 10.1371/journal.pbio.0020005)
Authors:
Gilad Y., Wiebe V., Przeworski M., Lancet D. & Pääbo S. (2007),
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Association of the RGS2 gene with extrapyramidal symptoms induced by treatment with antipsychotic medication
Authors:
Greenbaum L., Strous R. D., Kanyas K., Merbl Y., Horowitz A., Karni O., Katz E., Kotler M., Olender T., Deshpande S. N., Lancet D., Ben-Asher E. & Lerer B. (2007),
Pharmacogenetics and Genomics. 17, 7, p. 519-528
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Motif module map reveals enforcement of aging by continual NF-κB activity
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ZIPK: A unique case of murine-specific divergence of a conserved vertebrate gene
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Correction: A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila (PLos Biology (2007) 5, 10, (e251) DOI: 10.1371/journal.pbio.0050251)
Authors:
Arama E., Bader M., Rieckhof G. E. & Stellar H. (2007),
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Widespread ectopic expression of olfactory receptor genes
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Feldmesser E., Olender T., Khen M., Yanai I., Ophir R. & Lancet D. (2006),
BMC Genomics. 7
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Detection of apoptosis by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling and acridine orange in Drosophila embryos and adult male gonads
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Expoldb: Expression linked polymorphism database with inbuilt tools for analysis of expression and simple repeats
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Sharma V. K., Sharma A., Kumar N., Khandelwal M., Mandapati K. K., Horn-Saban S., Strichman-Almashanu L., Lancet D., Brahmachari S. K. & Ramachandran S. (2006),
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The association of DNA sequence variation at the MAOA genetic locus with quantitative behavioural traits in normal males
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Variations in the human olfactory receptor pathway
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ATM haplotypes and breast cancer risk in Jewish high-risk women
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Koren M., Kimmel G., Ben-Asher E., Gal I., Papa M. Z., Beckmann J. S., Lancet D., Shamir R. & Friedman E. (2006),
British Journal of Cancer. 94, 10, p. 1537-1543
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The two Drosophila cytochrome C proteins can function in both respiration and caspase activation
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Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes
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Greenbaum L., Kanyas K., Karni O., Merbl Y., Olender T., Horowitz A., Yakir A., Lancet D., Ben-Asher E. & Lerer B. (2006),
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Ancient genomic architecture for mammalian olfactory receptor clusters
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Cytochrome c-d regulates developmental apoptosis in the Drosophila retina
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Genetic basis of olfactory deficits
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Nuclear import of Ho endonuclease utilizes two nuclear localization signals and four importins of the ribosomal import system
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The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23 [3]
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Amann D., Avidan N., Kanyas K., Kohn Y., Hamdan A., Ben-Asher E., Macciardi F., Beckmann J., Lancet D. & Lerer B. (2006),
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Hsp90 recognizes a common surface on client kinases
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Citri A., Harari D., Shohat G., Ramakrishnan P., Gan J., Lavi S., Eisenstein M., Kimchi A., Wallach D., Pietrokovski S. & Yarden Y. (2006),
Journal of Biological Chemistry. 281, 20, p. 14361-14369
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AHI1, a pivotal neurodevelopmental gene, and C6orf217 are associated with susceptibility to schizophrenia
Authors:
Amann Zalcenstein D., Avidan N., Kanyas K., Ebstein R. P., Kohn Y., Hamdan A., Ben-Asher E., Karni O., Mujaheed M., Segman R. H., Maier W., Macciardi F., Beckmann J. S., Lancet D. & Lerer B. (2006),
European Journal of Human Genetics. 14, 10, p. 1111-1119
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Compositional complementarity and prebiotic ecology in the origin of life
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Hunding A., Kepes F., Lancet D., Minsky A., Norris V., Raine D., Sriram K. & Root-Bernstein R. (2006),
BioEssays. 28, 4, p. 399-412
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A genomic code for nucleosome positioning
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Segal E., Fondufe-Mittendorf Y., Chen L., Thastroem A., Field Y., Moore I. K., Wang J. Z. & Widom J. (2006),
Nature. 442, 7104, p. 772-778
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A probabilistic classifier for olfactory receptor pseudogenes
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LEMD3: The gene responsible for bone density disorders (osteopoikilosis)
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Ben-Asher E., Zelzer E. & Lancet D. (2005), Israel Medical Association Journal. 7, 4, p. 273-274
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Assessing natural variations in gene expression in humans by comparing with monozygotic twins using microarrays
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Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha
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Enhanced statistics for local alignment of multiple alignments improves prediction of protein function and structure
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Genotype phenotype correlations in Israeli colorectal cancer patients
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Starinsky S., Figer A., Ben-Asher E., Geva R., Flex D., Fidder H., Zidan J., Lancet D. & Friedman E. (2005),
International Journal of Cancer. 114, 1, p. 58-73
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Algal viruses with distinct intraspecies host specificities include identical intein elements
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Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
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Yanai I., Benjamin H., Shmoish M., Chalifa-Caspi V., Shklar M., Ophir R., Bar-Even A., Horn-Saban S., Safran M., Domany E., Lancet D. & Shmueli O. (2005),
Bioinformatics. 21, 5, p. 650-659
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The autophagy-associated Atg8 gene family operates both under favourable growth conditions and under starvation stresses in Arabidopsis plants
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GeneTide - Terra Incognita Discovery Endeavor: A new transcriptome focused member of the GeneCards/GeneNote suite of databases
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Modular genes with metazoan-specific domains have increased tissue specificity
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Cohen-Gihon I., Lancet D. & Yanai I. (2005),
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Polymer gard: Computer simulation of covalent bond formation in reproducing molecular assemblies
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Separating the contribution of translational and rotational diffusion to protein association
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Alternative splicing and gene duplication are inversely correlated evolutionary mechanisms
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Conservation anchors in the vertebrate genome
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Early systems biology and prebiotic networks
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Shenhav B., Solomon A., Lancet D. & Kafri R. (2005), Transactions On Computational Systems Biology I. p. 14-27
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One-Block CYRCA: An automated procedure for identifying multiple-block alignments from single block queries
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Graded artificial chemistry in restricted boundaries
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Protein splicing and auto-cleavage of bacterial intein-like domains lacking a C '-flanking nucleophilic residue
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The lipid world: From catalytic and informational headgroups to micelle replication and evolution without nucleic acids
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GeneAnnot: Comprehensive two-way linking between oligonucleotide array probesets and GeneCards genes
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Bioinformatics. 20, 9, p. 1457-1458
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Genomic profiling of interpopulation diversity guides prioritization of candidate-genes for autoimmunity
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The canine olfactory subgenome
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The olfactory receptor universe - From whole genome analysis to structure and evolution
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Olender T., Feldmesser E., Atarot T., Eisenstein M. & Lancet D. (2004), Genetics and Molecular Research. 3, 4, p. 545-553
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Prospects of a computational origin of life endeavor
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Protein Splicing of Inteins with Atypical Glutamine and Aspartate C-terminal Residues
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NIPBL gene responsible for Cornelia de Lange syndrome, a severe developmental disorder
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Ben-Asher E. & Lancet D. (2004), Israel Medical Association Journal. 6, 9, p. 571-572
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A new gene for the Charcot-Marie-Tooth disorder
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5-lipoxygenase activating protein (ALOX5AP): Association with cardiovascular infarction and stroke
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Ben-Asher E. & Lancet D. (2004), Israel Medical Association Journal. 6, 5, p. 318-319
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Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisons
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Is the G72/G30 locus associated with schizophrenia? Single nucleotide polymorphisms, haplotypes, and gene expression analysis
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Korostishevsky M., Kaganovich M., Cholostoy A., Ashkenazi M., Ratner Y., Dahary D., Bernstein J., Bening-Abu-Shach U., Ben-Asher E., Lancet D., Ritsner M. & Navon R. (2004),
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Recent innovations in the genecards suite
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Network analysis of protein structures identifies functional residues
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Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates
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PLoS Biology. 2, 1
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Probability rule for chiral recognition
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New type of polyubiquitin-like genes with intein-like autoprocessing domains
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Computer simulation of protocells
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Lancet D. (2003), Computational Methods In Systems Biology, Proceedings. 2602, p. 194-197
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An eNose algorithm for identifying chemicals and determining their concentration
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GeneLoc: Exon-based integration of human genome maps
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Human Olfactory Receptors
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Mesobiotic emergence: Molecular and ensemble complexity in early evolution
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Shenhav B., Segre D. & Lancet D. (2003),
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A feature extraction method for chemical sensors in electronic noses
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Human specific loss of olfactory receptor genes
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GeneNote: Whole genome expression profiles in normal human tissues
Authors:
Shmueli O., Horn-Saban S., Chalifa-Caspi V., Shmoish M., Ophir R., Benjamin-Rodrig H., Safran M., Domany E. & Lancet D. (2003),
Comptes Rendus Biologies. 326, 10-11, p. 1067-1072
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Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data
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From subgenome analysis to protein structure
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Natural selection on the olfactory receptor gene family in humans and chimpanzees
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Human gene-centric databases at the Weizmann Institute of science: GeneCards, UDB, CroW 21 and HORDE
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Safran M., Chalifa-Caspi V., Shmueli O., Olender T., Lapidot M., Rosen N., Shmoish M., Peter Y., Glusman G., Feldmesser E., Adato A., Peter I., Khen M., Atarot T., Groner Y. & Lancet D. (2003),
Nucleic Acids Research. 31, 1, p. 142-146
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Distribution and function of new bacterial intein-like protein domains
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Caspase activity and a specific cytochrome c are required for sperm differentiation in Drosophila
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Towards an odor communication system
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Distribution of split DnaE inteins in cyanobacteria
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Different noses for different people
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New types of conserved sequence domains in DNA-binding regions of homing endonucleases
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Sitbon E. & Pietrokovski S. (2003),
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GeneCards™ 2002: An evolving human gene compendium
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Safran M., Solomon I., Shmueli O., Lapidot M., Shen-Orr S., Adato A., Ben-Dor U., Esterman N., Rosen N., Peter I., Olender T., Chalifa-Caspi V. & Lancet D. (2002),
Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002. p. 339
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USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses
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Adato A., Vreugde S., Joensuu T., Avidan N., Hamalainen R., Belenkiy O., Olender T., Bonne-Tamir B., Ben-Asher E., Espinos C., Millan J., Lehesjoki A., Flannery J., Avraham K., Pietrokovski S., Sankila E., Beckmann J. & Lancet D. (2002),
European Journal of Human Genetics. 10, 6, p. 339-350
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GeneCards™ 2002: Towards a complete, object-oriented, human gene compendium
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Bioinformatics. 18, 11, p. 1542-1543
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Evidence for positive selection and population structure at the human MAO-A gene
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Pharmacogenetic development of personalized medicine: Multiple sclerosis treatment as a model
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Test of a statistical model for molecular recognition in biological repertoires
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Population differences in haplotype structure within a human olfactory receptor gene cluster
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DEFOG: A practical scheme for deciphering families of genes
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Computational capacity of an odorant discriminator: The linear separability of curves
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The human olfactory subgenome: from sequence to structure and evolution
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Exact Inference in Networks with Discrete Children of Continuous Parents
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Consistency analysis of similarity between multiple alignments: Prediction of protein function and fold structure from analysis of local sequence motifs
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Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1
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Levanon D., Glusman C., Bangsow T., Ben-Asher E., Male D., Avidan N., Bangsow C., Hattori M., Taylor T., Taudien S., Blechschmidt K., Shimizu N., Rosenthal A., Sakaki Y., Lancet D. & Groner Y. (2001),
Gene. 262, 1-2, p. 23-33
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Visualizing large-scale genomic sequences: The GESTALT workbench produces interactive genome graphs for quick and intuitive sequence interpretation
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Mouse-human orthology relationships in an olfactory receptor gene cluster
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The Lipid World
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Estimating the size of the olfactory repertoire
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A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel
Authors:
Lahat H., Pras E., Olender T., Avidan N., Ben-Asher E., Man O., Levy-Nissenbaum E., Khoury A., Lorber A., Goldman B., Lancet D. & Eldar M. (2001),
American Journal of Human Genetics. 69, 6, p. 1378-1384
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Erratum: Initial sequencing and analysis of the human genome: International Human Genome Sequencing Consortium (Nature (2001) 409 (860-921))
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Initial sequencing and analysis of the human genome
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The UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene is mutated in recessive hereditary inclusion body myopathy
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Eisenberg I., Avidan N., Potikha T., Hochner H., Chen M., Olender T., Barash M., Shemesh M., Sadeh M., Grabov-Nardini G., Shmilevich I., Friedmann A., Karpati G., Bradley W., Baumbach L., Lancet D., Ben-Asher E., Beckmann J. & Argov Z. (2001),
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The molecular roots of compositional inheritance
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Intein spread and extinction in evolution
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Mucolipidosis type IV: Novel MCOLN1 mutations in Jewish and Mon-Jewish patients and the frequency of the disease in the Ashkenazi Jewish population
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Bargal R., Avidan N., Olender T., Ben-Asher E., Zeigler M., Raas-Rothschild A., Frumkin A., Ben-Yoseph O., Friedlender Y., Lancet D. & Bach G. (2001),
Human Mutation. 17, 5, p. 397-402
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The RUNX3 gene - Sequence, structure and regulated expression
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Gene. 279, 2, p. 221-232
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Identification of new signaling components in the Drosophila genome sequence
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The complete human olfactory subgenome
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Doublecortin mutations cluster in evolutionarily conserved functional domains
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Compositional genomes: Prebiotic information transfer in mutually catalytic noncovalent assemblies
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Identification of the gene causing mucolipidosis type IV
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Nature Genetics. 26, 1, p. 118-121
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Identification and characterization of coding single-nucleotide polymorphisms within a human olfactory receptor gene cluster
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Prebiotic evolution of amphiphilic assemblies far from equilibrium: From compositional information to sequence-based biopolymers
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Composing life
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The genomic structure of human olfactory receptor genes
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Harvesting the human genome: The Israeli perspective
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Ben-Asher E., Chalifa-Caspi V., Horn-Saban S., Avidan N., Olender Z., Adato A., Glusman G., Safran M., Rubinstein M. & Lancet D. (2000), Israel Medical Association Journal. 2, 9, p. 657-664
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Increased coverage of protein families with the Blocks Database servers
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GESTALT: A workbench for automatic integration and visualization of large-scale genomic sequence analyses
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Glusman G. & Lancet D. (2000),
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The olfactory receptor gene superfamily: Data mining, classification, and nomenclature
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Dichotomy of single-nucleotide polymorphism haplotypes in olfactory receptor genes and pseudogenes
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Sequence, structure, and evolution of a complete human olfactory receptor gene cluster
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Blocks-based methods for detecting protein homology
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Fine-tuning an engineered intein
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New features of the Blocks Database servers
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Blocks+: A non-redundant database of protein alignment blocks derived from multiple compilations
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kPROT: A knowledge-based scale for the propensity of residue orientation in transmembrane segments. Application to membrane protein structure prediction
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The variable and conserved interfaces of modeled olfactory receptor proteins
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Isolation and characterization of a split B-type DNA polymerase from the archaeon Methanobacterium thermoautotrophicum ΔH
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GARDobes: Primordial cell nano-precursors with organic catalysis, compositional genome and capacity to evolve
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Molecular biology of olfactory receptors
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Primate evolution of an olfactory receptor cluster: Diversification by gene conversion and recent emergence of pseudogenes
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Configuration of the catalytic GIY-YIG domain of intron endonuclease I-Tevl: Coincidence of computational and molecular findings
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Olfaction: Good reception in fruitfly antennae
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A statistical chemistry approach to the origin of life
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