“The immune system of bacteria: Beyond CRISPR”

Date:
08
Tuesday
November
2022
Lecture / Seminar
Time: 10:00-11:00
Location: Nella and Leon Benoziyo Building for Biological Sciences
Lecturer: Prof. Rotem Sorek
Organizer: Department of Biomolecular Sciences
Contact: levana.ayvazo@weizmann.ac.il
Details: Dept. of Molecular Genetics
Abstract: The arms race between bacteria and phages led to the development of sophisticate ... Read more The arms race between bacteria and phages led to the development of sophisticated anti-phage defense systems, including CRISPR-Cas and restriction systems. We have recently reported that the microbial pan-genome contains many new defense systems whose function was so far unexplored. The talk will describe the functions of recently discovered new anti-phage systems. These include systems that utilize secondary metabolites for intracellular or as chemical defense against phages. Surprisingly, our studies show that bacterial defense from phage gave rise to key components in the eukaryotic immune system.
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