All Publications

  • Identification of bacteria-derived HLA-bound peptides in melanoma

    Authors: Kalaora S., Nagler A., Nejman D., Alon M., Barbolin C., Barnea E., Ketelaars S. L. C., Cheng K., Vervier K., Shental N., Bussi Y., Rotkopf R., Levy R., Benedek G., Trabish S., Dadosh T., Levin-Zaidman S., Geller L. T., Wang K., Greenberg P., Yagel G., Peri A., Fuks G., Bhardwaj N., Reuben A., Hermida L., Johnson S. B., Galloway-Peña J. R., Shropshire W. C., Bernatchez C., Haymaker C., Arora R., Roitman L., Eilam R., Weinberger A., Lotan-Pompan M., Lotem M., Levin Y., Lawley T. D., Adams D. J., Levesque M. P., Besser M. J., Schachter J., Golani O., Segal E., Ruppin E., Kvistborg P., Peterson S. N., Wargo J. A., Straussman R. & Samuels Y. (2021), Nature (London). 592, 7852, p. 138-143
  • Ecological significance of extracellular vesicles in modulating host-virus interactions during algal blooms

    Authors: Schatz D., Schleyer G., Saltvedt M. R., Sandaa R., Feldmesser E. & Vardi A. (2021), The ISME Journal.
  • 20S proteasomes secreted by the malaria parasite promote its growth

    Authors: Dekel E., Yaffe D., Rosenhek-Goldian I., Ben-Nissan G., Ofir-Birin Y., Morandi M. I., Ziv T., Sisquella X., Pimentel M. A., Nebl T., Kapp E., Ohana Daniel Y., Karam P. A., Alfandari D., Rotkopf R., Malihi S., Temin T. B., Mullick D., Revach O. Y., Rudik A., Gov N. S., Azuri I., Porat Z., Bergamaschi G., Sorkin R., Wuite G. J., Avinoam O., Carvalho T. G., Cohen S. R., Sharon M. & Regev-Rudzki N. (2021), Nature Communications. 12, 1, 1172
  • Viral infection of algal blooms leaves a unique metabolic footprint on the dissolved organic matter in the ocean

    Authors: Kuhlisch C., Schleyer G., Shahaf N., Vincent F., Schatz D. & Vardi A. (2021), Science advances. 7, 25, eabf4680
  • Visualizing active viral infection reveals diverse cell fates in synchronized algal bloom demise

    Authors: Vincent F., Sheyn U., Porat Z., Schatz D. & Vardi A. (2021), Proceedings of the National Academy of Sciences - PNAS. 118, 11, p. e2021586118-
  • The distribution of cellular turnover in the human body

    Authors: Sender R. & Milo R. (2021), Nature Medicine. 27, 1, p. 45-48
  • Maximization of information transmission influences selection of native phosphorelay architectures

    Authors: Alves R., Salvadó B., Milo R., Vilaprinyo E. & Sorribas A. (2021), PeerJ (San Francisco, CA). 9, e11558
  • Extracellular Vesicles From Epicardial Fat Facilitate Atrial Fibrillation

    Authors: Shaihov-Teper O., Ram E., Ballan N., Brzezinski R. Y., Naftali-Shani N., Masoud R., Ziv T., Lewis N., Schary Y., Levin-Kotler L., Volvovitch D., Zuroff E. M., Amunts S., Regev-Rudzki N., Sternik L., Raanani E., Gepstein L. & Leor J. (2021), Circulation (New York, N.Y.). 143, 25, p. 2475-2493
  • Photovoltaic-driven microbial protein production can use land and sunlight more efficiently than conventional crops

    Authors: Leger D., Matassa S., Noor E., Shepon A., Milo R. & Bar-Even A. (2021), Proceedings of the National Academy of Sciences - PNAS. 118, 26, e201502511
  • Diel cycle of sea spray aerosol concentration

    Authors: Flores J. M., Bourdin G., Kostinski A. B., Altaratz O., Dagan G., Lombard F., Haëntjens N., Boss E., Sullivan M. B., Gorsky G., Lang Yona N., Trainic M., Romac S., Voolstra C. . R., Rudich Y., Vardi A. & Koren I. (2021), Nature Communications. 12, 5476
  • Microscale tracking of coral-vibrio interactions

    Authors: Gavish A. R., Shapiro O. H., Kramarsky-Winter E. & Vardi A. (2021), ISME Communications. 1, 18
  • Bistability in oxidative stress response determines the migration behavior of phytoplankton in turbulence

    Authors: Carrara F., Sengupta A., Behrendt L., Vardi A. & Stocker R. (2021), Proceedings of the National Academy of Sciences of the United States of America. 118, 5, 2005944118
  • Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration

    Authors: Ofir-Birin Y., Ben Ami Pilo H., Camacho A. C., Rudik A., Rivkin A., Revach O., Nir N., Tamin T. B., Karam P. A., Kiper E., Peleg Y., Nevo R., Solomon A., Havkin-Solomon T., Rojas A., Rotkopf R., Porat Z., Avni D., Schwartz E., Zillinger T., Hartmann G., Di Pizio A., Ben Quashie N., Dikstein R., Gerlic M., Torrecilhas A. C., Levy C., Hoen E. N. M. N., Bowie A. G. & Regev-Rudzki N. (2021), Nature Communications. 12, 4851
  • A single-cell view on alga-virus interactions reveals sequential transcriptional programs and infection states

    Authors: Ku C., Sheyn U., Sebe-Pedros A., Ben-Dor S., Schatz D., Tanay A., Rosenwasser S. & Vardi A. (2020), Science Advances. 6, 21, 4137
  • Predicting and affecting response to cancer therapy based on pathway-level biomarkers

    Authors: Ben-Hamo R., Berger A. J., Gavert N., Miller M., Pines G., Oren R., Pikarsky E., Benes C. H., Neuman T., Zwang Y., Efroni S., Getz G. & Straussman R. (2020), Nature Communications. 11, 1, 3296
  • Tara Pacific Expedition's Atmospheric Measurements of Marine Aerosols across the Atlantic and Pacific Oceans: Overview and Preliminary Results

    Authors: Flores J. M., Bourdin G., Altaratz O., Trainic M., Lang-Yona N., Dzimban E., Steinau S., Tettich F., Planes S., Allemand D., Agostini S., Banaigs B., Boissin E., Boss E., Douville E., Forcioli D., Furla P., Galand P. E., Sullivan M. B., Gilson E., Lombard F., Moulin C., Pesant S., Poulain J., Reynaud S., Romac S., Sunagawa S., Thomas O. P., Trouble R., de Vargas C., Thurber R. V., Voolstra C. R., Wincker P., Zoccola D., Bowler C., Gorsky G., Rudich Y., Vardi A. & Koren R. (2020), Bulletin of the American Meteorological Society. 101, 5, p. E536-E554
  • A genome assembly and the somatic genetic and epigenetic mutation rate in a wild long-lived perennial Populus trichocarpa

    Authors: Hofmeister B. T., Denkena J., Colomé-Tatché M., Shahryary Y., Hazarika R., Grimwood J., Mamidi S., Jenkins J., Grabowski P. P., Sreedasyam A., Shu S., Barry K., Lail K., Adam C., Lipzen A., Sorek R., Kudrna D., Talag J., Wing R., Hall D. W., Jacobsen D., Tuskan G. A., Schmutz J., Johannes F. & Schmitz R. J. (2020), Genome Biology. 21, 1, p. 259, 259
  • Immunomodulatory Properties of Leishmania Extracellular Vesicles During Host-Parasite Interaction: Differential Activation of TLRs and NF-kappa B Translocation by Dermotropic and Viscerotropic Species

    Authors: Nogueira P. M., de Menezes-Neto A., Borges V. M., Descoteaux A., Torrecilhas A. C., Xander P., Revach O., Regev-Rudzki N. & Soares R. P. (2020), Frontiers in Cellular and Infection Microbiology. 10, 380
  • The human tumor microbiome is composed of tumor type-specific intracellular bacteria

    Authors: Nejman D., Livyatan I., Fuks G., Gavert N., Zwang Y., Geller L. T., Rotter-Maskowitz A., Weiser R., Mallel G., Gigi E., Meltser A., Douglas G. M., Kamer I., Gopalakrishnan V., Dadosh T., Levin-Zaidman S., Avnet S., Atlan T., Cooper Z. A., Arora R., Cogdill A. P., Khan M. A. W., Ologun G., Bussi Y., Weinberger A., Lotan-Pompan M., Golani O., Perry G., Rokah M., Bahar-Shany K., Rozeman E. A., Blank C. U., Ronai A., Shaoul R., Amit A., Dorfman T., Kremer R., Cohen Z. R., Harnof S., Siegal T., Yehuda-Shnaidman E., Gal-Yam E. N., Shapira H., Baldini N., Langille M. G. I., Ben-Nun A., Kaufman B., Nissan A., Golan T., Dadiani M., Levanon K., Bar J., Yust-Katz S., Barshack I., Peeper D. S., Raz D. J., Segal E., Wargo J. A., Sandbank J., Shental N. & Straussman R. (2020), Science. 368, 6494, p. 973-980
  • Point mutations in topoisomerase I alter the mutation spectrum in E. coli and impact the emergence of drug resistance genotypes

    Authors: Bachar A., Itzhaki E., Gleizer S., Shamshoom M., Milo R. & Antonovsky N. (2020), Nucleic Acids Research. 48, 2, p. 761-769
  • The Possession of Coccoliths Fails to Deter Microzooplankton Grazers

    Authors: Mayers K. M., Poulton A. J., Bidle K., Thamatrakoln K., Schieler B., Giering S. L., Wells S. R., Tarran G. A., Mayor D., Johnson M., Riebesell U., Larsen A., Vardi A. & Harvey E. L. (2020), Frontiers in Marine Science. 7, 569896
  • Deep microbial analysis of multiple placentas shows no evidence for a placental microbiome

    Authors: Kuperman A. A., Zimmerman A., Hamadia S., Ziv O., Gurevich V., Fichtman B., Gavert N., Straussman R., Rechnitzer H., Barzilay M., Shvalb S., Bornstein J., Ben-Shachar I., Yagel S., Haviv I. & Koren O. (2020), BJOG: An International Journal of Obstetrics and Gynaecology. 127, 2, p. 159-169
  • Sensitivity of warm clouds to large particles in measured marine aerosol size distributions-a theoretical study

    Authors: Dror T., Michel Flores J., Altaratz O., Dagan G., Levin Z., Vardi A. & Koren I. (2020), Atmospheric Chemistry and Physics. 20, 23, p. 15297-15306
  • High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function

    Authors: Grosheva I., Zheng D., Levy M., Polansky O., Lichtenstein A., Golani O., Dori-Bachash M., Moresi C., Shapiro H., Del Mare-Roumani S., Valdes-Mas R., He Y., Karbi H., Chen M., Harmelin A., Straussman R., Yissachar N., Elinav E. & Geiger B. (2020), Gastroenterology. 159, 5, p. 1807-1823
  • Airborne microplastic particles detected in the remote marine atmosphere

    Authors: Trainic M., Flores J. M., Pinkas I., Pedrotti M. L., Lombard F., Bourdin G., Gorsky G., Boss E., Rudich Y., Vardi A. & Koren I. (2020), Communications Earth & Environment. 1, 1, 64
  • Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems

    Authors: Millman A., Melamed S., Amitai G. & Sorek R. (2020), Nature Microbiology. 12, p. 1608-+
  • Trypanosoma cruzi-Infected Human Macrophages Shed Proinflammatory Extracellular Vesicles That Enhance Host-Cell Invasion via Toll-Like Receptor 2

    Authors: Cronemberger-Andrade A., Xander P., Soares R. P., Pessoa N. L., Campos M. A., Ellis C. C., Grajeda B., Ofir-Birin Y., Almeida I. C., Regev-Rudzki N. & Torrecilhas A. C. (2020), Frontiers in Cellular and Infection Microbiology. 10, 99
  • Characterization of the human tumor microbiome reveals tumor-type specific intra-cellular bacteria

    Authors: Livyatan I., Nejman D., Shental N. & Straussman R. (2020), OncoImmunology. 9, 1, 1800957
  • Peptide-based quorum sensing systems in Paenibacillus polymyxa

    Authors: Voichek M., Maaß S., Kroniger T., Becher D. & Sorek R. (2020), Life Science Alliance. 3, 10, 202000847
  • Highly active rubiscos discovered by systematic interrogation of natural sequence diversity

    Authors: Davidi D., Shamshoum M., Guo Z., Bar‐On Y. M., Prywes N., Oz A., Jablonska J., Flamholz A., Wernick D. G., Antonovsky N., Pins B., Shachar L., Hochhauser D., Peleg Y., Albeck S., Sharon I., Mueller‐Cajar O. & Milo R. (2020), The EMBO Journal. 39, 18, 104081
  • Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases

    Authors: Minina E. A., Staal J., Alvarez V. E., Berges J. A., Berman-Frank I., Beyaert R., Bidle K. D., Bornancin F., Casanova M., Cazzulo J. J., Choi C. J., Coll N. S., Dixit V. M., Dolinar M., Fasel N., Funk C., Gallois P., Gevaert K., Gutierrez-Beltran E., Hailfinger S., Klemenčič M., Koonin E. V., Krappmann D., Linusson A., Machado M. F., Madeo F., Megeney L. A., Moschou P. N., Mottram J. C., Nyström T., Osiewacz H. D., Overall C. M., Pandey K. C., Ruland J., Salvesen G. S., Shi Y., Smertenko A., Stael S., Ståhlberg J., Suárez M. F., Thome M., Tuominen H., Van Breusegem F., van der Hoorn R. A., Vardi A., Zhivotovsky B., Lam E. & Bozhkov P. V. (2020),
  • Abortive Infection: Bacterial Suicide as an Antiviral Immune Strategy

    Authors: Lopatina A., Tal N. & Sorek R. (2020), Annual Review of Virology. 7, p. 371-384
  • Prokaryotic viperins produce diverse antiviral molecules

    Authors: Bernheim A., Millman Dayan A. J., Ofir G., Meitav G., Avraham C., Shomar H., Rosenberg M. M., Tal N., Melamed S., Amitai G. & Sorek R. (2020), Nature. 7840, p. 120-U230
  • Antibody-free labeling of malaria-derived extracellular vesicles using flow cytometry

    Authors: Dekel E., Karam P. A., Ohana-Daniel Y., Biton M., Regev-Rudzki N. & Porat Z. (2020), Biomedicines. 8, 5, 98
  • STING cyclic dinucleotide sensing originated in bacteria

    Authors: Morehouse B. R., Govande A. A., Millman A., Keszei A. F. A., Lowey B., Ofir G., Shao S., Sorek R. & Kranzusch P. J. (2020), Nature. 586, 7829, p. 429-433
  • Engineering Microbes to Produce Fuel, Commodities, and Food from CO2

    Authors: Gleizer S., Bar-On Y. M., Ben-Nissan R. & Milo R. (2020), Cell Reports Physical Science. 1, 10, 100223
  • Algal blooms

    Authors: Schleyer G. & Vardi A. (2020), Current Biology. 30, 19, p. R1116-R1118
  • Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression

    Authors: Parhi L., Alon-Maimon T., Sol A., Nejman D., Shhadeh A., Fainsod-Levi T., Yajuk O., Isaacson B., Abed J., Maalouf N., Nissan A., Sandbank J., Yehuda-Shnaidman E., Ponath F., Vogel J., Mandelboim O., Granot Z., Straussman R. & Bachrach G. (2020), Nature Communications. 11, 1, 3259
  • Schistosomal extracellular vesicle-enclosed miRNAs modulate host T helper cell differentiation

    Authors: Meningher T., Barsheshet Y., Ofir-Birin Y., Gold D., Brant B., Dekel E., Sidi Y., Schwartz E., Regev-Rudzki N., Avni O. & Avni D. (2020), EMBO Reports. 21, 1, 47882
  • Global human-made mass exceeds all living biomass

    Authors: Elhacham E., Ben-Uri L., Grozovski J., Bar-On Y. M. & Milo R. (2020), Nature. 588, 7838, p. 442-444
  • Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5

    Authors: Warszawski S., Dekel E., Campeotto I., Marshall J. M., Wright K. E., Lyth O., Knop O., Regev-Rudzki N., Higgins M. K., Draper S. J., Baum J. & Fleishman S. J. (2020), Proteins-Structure Function And Bioinformatics. 88, 1, p. 187-195
  • Functional reconstitution of a bacterial CO 2 concentrating mechanism in Escherichia coli.

    Authors: Flamholz A. I., Dugan E., Blikstad C., Gleizer S., Ben-Nissan R., Amram S., Antonovsky N., Ravishankar S., Noor E., Bar-Even A., Milo R. & Savage D. F. (2020), eLife. 9, 59882
  • SARS-CoV-2 (COVID-19) by the numbers

    Authors: Bar-On Y. M., Flamholz A., Phillips R. & Milo R. (2020), eLife. 9, 57309
  • Bacterial Retrons Function In Anti-Phage Defense

    Authors: Millman A., Bernheim A., Stokar-Avihail A., Fedorenko T., Voichek M., Leavitt A., Oppenheimer-Shaanan Y. & Sorek R. (2020), Cell. 183, 6, p. 1551-1561
  • Extracellular vesicles in parasite survival

    Authors: Ofir-Birin Y. & Regev-Rudzki N. (2019), Science. 363, 6429, p. 817-818
  • Cooperativity between stromal cytokines drives the invasive migration of human breast cancer cells

    Authors: Elisha Y., Sagi Y., Klein G., Straussman R. & Geiger B. (2019), Philosophical Transactions of the Royal Society B: Biological Sciences. 374, 1779, 20180231
  • Conversion of Escherichia coli to Generate All Biomass Carbon from CO2

    Authors: Gleizer S., Ben-Nissan R., Bar-On Y. M., Antonovsky N., Noor E., Zohar Y., Jona G., Krieger E., Shamshoum M., Bar-Even A. & Milo R. (2019), Cell. 179, 6, p. 1255-1263
  • N-Acyl Homoserine Lactone Derived Tetramic Acids Impair Photosynthesis in Phaeodactylum tricornutum

    Authors: Stock F., Syrpas M., van Creveld S. G., Backx S., Blommaert L., Dow L., Stock W., Ruysbergh E., Lepetit B., Bailleul B., Sabbe K., De Kimpe N., Willems A., Kroth P. G., Vardi A., Vyverman W. & Mangelinckx S. (2019), ACS Chemical Biology. 14, 2, p. 198-203
  • Widespread Utilization of Peptide Communication in Phages Infecting Soil and Pathogenic Bacteria

    Authors: Stokar-Avihail A., Tal N., Erez Z., Lopatina A. & Sorek R. (2019), Cell Host & Microbe. 25, 5, p. 746-755.e5
  • The global mass and average rate of rubisco

  • A rhlI 5' UTR-Derived sRNA Regulates RhlR-Dependent Quorum Sensing in Pseudomonas aeruginosa

    Authors: Thomason M. K., Voichek M., Dar D., Addis V., Fitzgerald D., Gottesman S., Sorek R. & Greenberga E. P. (2019), mBio. 10, 5, e02253-19
  • Nitric oxide mediates oxylipin production and grazing defense in diatoms

    Authors: Johnson M. D., Edwards B. R., Beaudoin D. J., Van Mooy B. A. S. & Vardi A. (2019), Environmental Microbiology. 2, p. 629-645
  • Tuberculosis's cargoman: bacteria load RNA into host extracellular vesicles

    Authors: Biton M., Abou Karam P. & Regev-Rudzki N. (2019),
  • Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient

    Authors: Averbuch D., Safadi R., Dar D., Wolf D., Cherniak M., Sorek R. & Amit S. (2019), Pediatric Infectious Disease Journal. 38, 3, p. 297-299
  • Revisiting Trade-offs between Rubisco Kinetic Parameters

    Authors: Flamholz A., Prywes N., Moran U., David D., Bar-On Y. M., Oltrogge L. M., Alves R., Savage D. & Milo R. (2019), Biochemistry. 58, 31, p. 3365-3376
  • The Tara Pacific expedition-A pan-ecosystemic approach of the "-omics" complexity of coral reef holobionts across the Pacific Ocean

    Authors: , Flores J. M., Koren I., Lang-Yona N., Trainic M. & Vardi A. (2019), PLoS Biology. 17, 9, e3000483
  • The pan-immune system of bacteria: antiviral defence as a community resource

    Authors: Bernheim A. & Sorek R. (2019), Nature Reviews Microbiology. 18, p. 113-119
  • Toward unrestricted use of public genomic data: Publication interests should not limit access to public data

    Authors: Amann R. I., Baichoo S., Blencowe B. J., Bork P., Borodovsky M., Brooksbank C., Chain P. S. G., Colwell R. R., Daffonchio D. G., Danchin A., de Lorenzo V., Dorrestein P. C., Finn R. D., Fraser C. M., Gilbert J. A., Hallam S. J., Hugenholtz P., Ioannidis J. P. A., Jansson J. K., Kim J. F., Klenk H., Klotz M. G., Knight R., Konstantinidis K. T., Kyrpides N. C., Mason C. E., McHardy A. C., Meyer F., Ouzounis C. A., Patrinos A. A. N., Podar M., Pollard K. S., Ravel J., Munoz A. R., Roberts R. J., Rossello-Mora R., Sansone S., Schloss P. D., Schriml L. M., Setubal J. C., Sorek R., Stevens R. L., Tiedje J. M., Turjanski A., Tyson G. W., Ussery D. W., Weinstock G. M., White O., Whitman W. B. & Xenarios I. (2019), Science. 363, 6425, p. 350-352
  • Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

    Authors: Thery C., Witwer K. W., Aikawa E., Jose Alcaraz M., Anderson J. D., Andriantsitohaina R., Antoniou A., Arab T., Archer F., Atkin-Smith G. K., Ayre D. C., Bach J., Bachurski D., Baharvand H., Balaj L., Baldacchino S., Bauer N. N., Baxter A. A., Bebawy M., Beckham C., Zavec A. B., Benmoussa A., Berardi A. C., Bergese P., Bielska E., Blenkiron C., Bobis-Wozowicz S., Boilard E., Boireau W., Bongiovanni A., Borras F. E., Bosch S., Boulanger C. M., Breakefield X., Breglio A. M., Brennan M. A., Brigstock D. R., Brisson A., Broekman M. L. D., Bromberg J. F., Bryl-Gorecka P., Buch S., Buck A. H., Burger D., Busatto S., Buschmann D., Bussolati B., Buzas E., Byrd J. B., Camussi G., Carter D. R. F., Caruso S., Chamley L. W., Chang Y., Chaudhuri A. D., Chen C., Chen S., Cheng L., Chin A. R., Clayton A., Clerici S. P., Cocks A., Cocucci E., Coffey R. J., Cordeiro-da-Silva A., Couch Y., Coumans F. A. W., Coyle B., Crescitelli R., Criado M. F., D'Souza-Schorey C., Das S., de Candia P., De Santana Junior E. F., De Wever O., del Portillo H. A., Demaret T., Deville S., Devitt A., Dhondt B., Di Vizio D., Dieterich L. C., Dolo V., Dominguez Rubio A. P., Dominici M., Dourado M. R., Driedonks T. A. P., Duarte F., Duncan H. M., Eichenberger R. M., Ekstrom K., Andaloussi S. E. L., Elie-Caille C., Erdbrugger U., Falcon-Perez J. M., Fatima F., Fish J. E., Flores-Bellver M., Forsonits A., Frelet-Barrand A., Fricke F., Fuhrmann G., Gabrielsson S., Gamez-Valero A., Gardiner C., Gaertner K., Gaudin R., Gho Y. S., Giebel B., Gilbert C., Gimona M., Giusti I., Goberdhan D. C., Goergens A., Gorski S. M., Greening D. W., Gross J. C., Gualerzi A., Gupta G. N., Gustafson D., Handberg A., Haraszti R. A., Harrison P., Hegyesi H., Hendrix A., Hill A. F., Hochberg F. H., Hoffmann K. F., Holder B., Holthofer H., Hosseinkhani B., Hu G., Huang Y., Huber V., Hunt S., Ibrahim A. G., Ikezu T., Inal J. M., Isin M., Ivanova A., Jackson H. 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