Mitochondria at the interface between homeostasis and apoptosis

Date:
04
Monday
September
2017
Lecture / Seminar
Time: 14:00-15:00
Title: Cancer Research Club
Location: Max and Lillian Candiotty Building
Lecturer: Prof. Atan Gross
Organizer: Department of Immunology and Regenerative Biology
Contact: li.tzoref@weizmann.ac.il
Details: Dept. of Biological Regulation, Weizmann nInstitute
Abstract: Mitochondria are highly dynamic organelles that play fundamental roles in pivota ... Read more Mitochondria are highly dynamic organelles that play fundamental roles in pivotal cellular processes including energy production, metabolism, and apoptosis. Our scientific interests evolve around topics related to how these different mitochondrial processes are coordinated to regulate cellular stress responses and cellular fate. Over the years, we discovered a new pathway composed of the nuclear ATM kinase, pro-apoptotic BID, and mitochondrial MTCH2, connecting mitochondria metabolism to stress signals originating from the cell surface and nucleus. More recently, we revealed that MTCH2 is involved in regulating mitochondrial dynamics/fusion, providing a clue to the mechanism by which the pathway regulates mitochondrial function.
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