• Survivorship Data in Prostate Cancer: Where Are We and Where Do We Need To Be?

    Authors: Russell B., Beyer K., Lawlor A., Roobol M. J., Venderbos L. D., Remmers S., Briers E., MacLennan S. J., MacLennan S., Omar M. I., Van Hemelrijck M., Smith E., N'Dow J., Plass K., Ribal M., Mottet N., Shepherd R., Abbott T., Mastris K. & Lancet D. (2024),
  • Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma

    Authors: Kirschenbaum D., Xie K., Ingelfinger F., Katzenelenbogen Y., Abadie K., Look T., Sheban F., Phan T. S., Li B., Zwicky P., Yofe I., David E., Mazuz K., Hou J., Chen Y., Shaim H., Shanley M., Becker S., Qian J., Colonna M., Ginhoux F., Rezvani K., Theis F. J., Yosef N., Weiss T., Weiner A. & Amit I. (2024), Cell. 187, 1, p. 149-165.e23
  • Potent antitumor activity of anti-HER2 antibody-topoisomerase I inhibitor conjugate based on self-immolative dendritic dimeric-linker

    Authors: Liubomirski Y., Tiram G., Scomparin A., Gnaim S., Das S., Gholap S., Ge L., Yeini E., Shelef O., Zauberman A., Berger N., Kalimi D., Toister-Achituv M., Schröter C., Dickgiesser S., Tonillo J., Shan M., Deutsch C., Sweeney-Lasch S., Shabat D. & Satchi-Fainaro R. (2024), Journal of Controlled Release. 367, p. 148-157
  • IL-23 stabilizes an effector Treg cell program in the tumor microenvironment

    Authors: Wertheimer T., Zwicky P., Rindlisbacher L., Sparano C., Vermeer M., de Melo B. M. S., Haftmann C., Rückert T., Sethi A., Schärli S., Huber A., Ingelfinger F., Xu C., Kim D., Häne P., Fonseca da Silva A., Muschaweckh A., Nunez N., Krishnarajah S., Köhler N., Zeiser R., Oukka M., Korn T., Tugues S. & Becher B. (2024), Nature Immunology. 25, 3, p. 512-524
  • Embracing cancer complexity: Hallmarks of systemic disease

    Authors: Swanton C., Bernard E., Abbosh C., André F., Auwerx J., Balmain A., Bar-Sagi D., Bernards R., Bullman S., DeGregori J., Elliott C., Erez A., Evan G., Febbraio M. A., Hidalgo A., Jamal-Hanjani M., Joyce J. A., Kaiser M., Lamia K., Locasale J. W., Loi S., Malanchi I., Merad M., Musgrave K., Patel K. J., Quezada S., Wargo J. A., Weeraratna A., White E., Winkler F., Wood J. N., Vousden K. H. & Hanahan D. (2024), Cell. 187, 7, p. 1589-1616
  • Cell-penetrating peptide and cationic liposomes mediated siRNA delivery to arrest growth of chronic myeloid leukemia cells in vitro

    Authors: Vysochinskaya V., Zabrodskaya Y., Dovbysh O., Emelyanov A., Klimenko V., Knyazev N., Terterov I., Egorova M., Bogdanov A., Maslov M., Vasin A. & Dubina M. (2024), Biochimie. 221, p. 1-12
  • Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor

    Authors: Meril S., Bahlsen M., Eisenstein M., Savidor A., Levin Y., Bialik S., Pietrokovski S. & Kimchi A. (2024), Life Science Alliance. 7, 3, e202302338
  • Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma

    Authors: Spitzer A., Gritsch S., Nomura M., Jucht A., Fortin J., Raviram R., Weisman H. R., Gonzalez Castro L. N., Druck N., Chanoch-Myers R., Lee J. J., Mylvaganam R., Lee Servis R., Fung J. M., Lee C. K., Nagashima H., Miller J. J., Arrillaga-Romany I., Louis D. N., Wakimoto H., Pisano W., Wen P. Y., Mak T. W., Sanson M., Touat M., Landau D. A., Ligon K. L., Cahill D. P., Suvà M. L. & Tirosh I. (2024), Cancer Cell.
  • Cancer Hallmarks: Piecing the Puzzle Together

    Authors: Alcolea M. P., Alonso-Curbelo D., Ambrogio C., Bullman S., Correia A. L., Ernst A., Halbrook C. J., Kelly G. L., Lund A. W., Quail D. F., Ruscetti M., Shema E., Stromnes I. M. & Tam W. L. (2024), Cancer Discovery. 14, 4, p. 674-682
  • A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53

    Authors: Zoltsman G., Dang T. L., Kuchersky M., Faust O., Silva M. S., Ilani T., Wentink A. S., Bukau B. & Rosenzweig R. (2024), Molecular Cell.
  • FcγRIIB is an immune checkpoint limiting the activity of Treg-targeting antibodies in the tumor microenvironment

    Authors: Knorr D. A., Blanchard L., Leidner R. S., Jensen S. M., Meng R., Jones A., Ballesteros-Merino C., Bell R. B., Baez M., Marino A., Sprott D., Bifulco C. B., Piening B., Dahan R., Osorio J. C., Fox B. A. & Ravetch J. V. (2024), Cancer Immunology Research. 12, 3, p. 322-333
  • From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments

    Authors: Hajaj E., Pozzi S. & Erez A. (2024), Cold Spring Harbor perspectives in medicine. 14, 4
  • Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

    Authors: Lü Y. Q., Cho T., Mukherjee S., Suarez C. F., Gonzalez-Foutel N. S., Malik A., Martinez S., Dervovic D., Oh R. H., Langille E., Al-Zahrani K. N., Hoeg L., Lin Z. Y., Tsai R., Mbamalu G., Rotter V., Ashton-Prolla P., Moffat J., Chemes L. B., Gingras A. C., Oren M., Durocher D. & Schramek D. (2024), Molecular Systems Biology.
  • Update on current and new potential immunotherapies in breast cancer, from bench to bedside

    Authors: Alaluf E., Shalamov M. M. & Sonnenblick A. (2024), Frontiers in Immunology. 15, 1287824
  • Molecular imaging of tumor metabolism: Insight from pyruvate- and glucose-based deuterium MRI studies

    Authors: Montrazi E. T., Sasson K., Agemy L., Scherz A. & Frydman L. (2024), Science advances. 10, 11, eadm8600
  • Converging survival trends in non-small cell lung cancer patients with and without brain metastasis receiving state-of-the-art treatment

    Authors: Averbuch I., Tschernichovsky R., Yust-Katz S., Rotem O., Limon D., Kurman N., Icht O., Reinhorn D., Moskovitz M., Hanovich E., Benouaich-Amiel A., Siegal T., Zer A. & Gal O. (2024), Journal of Neuro-Oncology. 166, p. 461-469
  • Bispecific dendritic-T cell engager potentiates anti-tumor immunity

    Authors: Shapir Itai Y., Barboy O., Salomon R., Bercovich A., Xie K., Winter E., Shami T., Porat Z., Erez N., Tanay A., Amit I. & Dahan R. (2024), Cell. 187, 2, p. 375-389.e18
  • Programming a Ferroptosis-to-Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy

    Authors: Vinik Y., Maimon A., Dubey V., Raj H., Abramovitch I., Malitsky S., Itkin M., Ma'ayan A., Westermann F., Gottlieb E., Ruppin E. & Lev S. (2024), Advanced Science.
  • Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols

    Authors: Barboy O., Bercovich A., Li H., Lubling Y., Yalin A., Shapir Itai Y., Abadie K., Zada M., David E., Shlomi S., Katzenelenbogen Y., Adhemar D., Gur C., Yofe I., Feferman T., Cohen M., Dahan R., Newell E., Lifshitz A., Tanay A. & Amit I. (2024), Nature Cancer.
  • p53: A tale of complexity and context

    Authors: Oren M. & Prives C. (2024),
  • Signaling lymphocytic activation molecule family receptors as potential immune therapeutic targets in solid tumors

    Authors: Gunes M., Rosen S. T., Shachar I. & Gunes E. G. (2024), Frontiers in Immunology. 15, 1297473
  • Loss of EIF4G2 mediates aggressiveness in distinct human endometrial cancer subpopulations with poor survival outcome in patients

    Authors: Meril S., Muhlbauer Avni M., Lior C., Bahlsen M., Olender T., Savidor A., Krausz J., Belhanes Peled H., Birisi H., David N., Bialik S., Scherz-Shouval R., Ben David Y. & Kimchi A. (2024), Oncogene. 43, 15, p. 1098-1112
  • Melanoma and microbiota: Current understanding and future directions

    Authors: Routy B., Jackson T., Mählmann L., Baumgartner C. K., Blaser M., Byrd A., Corvaia N., Couts K., Davar D., Derosa L., Hang H. C., Hospers G., Isaksen M., Kroemer G., Malard F., McCoy K. D., Meisel M., Pal S., Ronai Z., Segal E., Sepich-Poore G. D., Shaikh F., Sweis R. F., Trinchieri G., van den Brink M., Weersma R. K., Whiteson K., Zhao L., McQuade J., Zarour H. & Zitvogel L. (2024), Cancer Cell. 42, 1, p. 16-34
  • CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods

    Authors: Jain S., Bakolitsa C., Brenner S. E., Radivojac P., Moult J., Repo S., Hoskins R. A., Andreoletti G., Barsky D., Chellapan A., Chu H., Dabbiru N., Kollipara N. K., Ly M., Neumann A. J., Pal L. R., Odell E., Fishilevich S., Lancet D. & Yosef N. (2024), Genome Biology. 25, 1, 53
  • Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure

    Authors: Su M., Fleischer T., Grosheva I., Horev M. B., Olszewska M., Mattioli C. C., Barr H., Plotnikov A., Carvalho S., Moskovich Y., Minden M. D., Chapal-Ilani N., Wainstein A., Papapetrou E. P., Dezorella N., Cheng T., Kaushansky N., Geiger B. & Shlush L. I. (2024), iScience. 27, 4, 109443
  • PRC2-independent actions of H3.3K27M in embryonic stem cell differentiation

    Authors: Cohen L. R. Z., Kaffe B., Deri E., Leibson C., Nissim-Rafinia M., Maman M., Harpaz N., Ron G., Shema E. & Meshorer E. (2023), Nucleic Acids Research. 51, 4, p. 1662-1673
  • In Synergy: Optimizing CAR T Development and Personalizing Patient Care Using Single-Cell Technologies

    Authors: Barboy O., Katzenelenbogen Y., Shalita R. & Amit I. (2023), Cancer Discovery. 13, 7, p. 1546-1555
  • A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy

    Authors: Stein-Thoeringer C. K., Saini N. Y., Zamir E., Blumenberg V., Schubert M. L., Mor U., Fante M. A., Schmidt S., Hayase E., Hayase T., Rohrbach R., Chang C. C., McDaniel L., Flores I., Gaiser R., Edinger M., Wolff D., Heidenreich M., Strati P., Nair R., Chihara D., Fayad L. E., Ahmed S., Iyer S. P., Steiner R. E., Jain P., Nastoupil L. J., Westin J., Arora R., Wang M. L., Turner J., Menges M., Hidalgo-Vargas M., Reid K., Dreger P., Schmitt A., Müller-Tidow C., Locke F. L., Davila M. L., Champlin R. E., Flowers C. R., Shpall E. J., Poeck H., Neelapu S. S., Schmitt M., Subklewe M., Jain M. D., Jenq R. R. & Elinav E. (2023), Nature Medicine. 29, 4, p. 906-916
  • Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets

    Authors: Beumers L., Vlachavas E. I., Borgoni S., Schwarzmüller L., Penso-Dolfin L., Michels B. E., Sofyali E., Burmester S., Heiss D., Wilhelm H., Yarden Y., Helm D., Will R., Goncalves A. & Wiemann S. (2023), NPJ Breast Cancer. 9, 1, 97
  • High-sensitivity deuterium metabolic MRI differentiates acute pancreatitis from pancreatic cancers in murine models

    Authors: Montrazi E. T., Sasson K., Agemy L., Peters D. C., Brenner O., Scherz A. & Frydman L. (2023), Scientific Reports. 13, 1, 19998
  • A clinical evaluation of an ex vivo organ culture system to predict patient response to cancer therapy

    Authors: Golan S., Bar V., Salpeter S. J., Neev G., Creiderman G., Kedar D., Aharon S., Turovsky L., Zundelevich A., Shahar H., Shapira H., Mallel G., Stossel E., Gavert N., Straussman R., Dotan Z., Berger R., Stossel C., Golan T., Halperin S., Leibovici D., Breuer S., Rottenberg Y., Applebaum L., Hubert A., Nechushtan H., Peretz T., Zick A., Chertin B., Koulikov D., Sonnenblick A. & Rosenbaum E. (2023), Frontiers in Medicine. 10, 1221484
  • Early death after a diagnosis of metastatic solid cancer–raising awareness and identifying risk factors from the SEER database

    Authors: Globus O., Sagie S., Lavine N., Barchana D. I. & Urban D. (2023), PLoS ONE. 18, 9, e0281561
  • Actin Filaments Couple thes Protrusive Tips to the Nucleus through the I‐BAR Domain Protein IRSp53 during the Migration of Cells on 1D Fibers

    Authors: Mukherjee A., Ron J. E., Hu H. T., Nishimura T., Hanawa-Suetsugu K., Behkam B., Mimori-Kiyosue Y., Gov N. S., Suetsugu S. & Nain A. S. (2023), Advanced Science. 10, 7, 2207368
  • Characterisation of knowledge of cancer, illness perceptions and their interaction among high-school students

  • Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short-term vs long-term survivors of glioblastoma

    Authors: Ofek P., Yeini E., Arad G., Danilevsky A., Pozzi S., Luna C. B., Dangoor S. I., Grossman R., Ram Z., Shomron N., Brem H., Hyde T. M., Geiger T. & Satchi-Fainaro R. (2023), International Journal of Cancer. 153, 3, p. 654-668
  • Spatial profiling technologies illuminate the tumor microenvironment

    Authors: Elhanani O., Ben-Uri R. & Keren L. (2023), Cancer Cell. 41, 3, p. 404-420
  • Definition of the contribution of an Osteopontin-producing CD11c+ microglial subset to Alzheimer’s disease

    Authors: Qiu Y., Shen X., Ravid O., Atrakchi D., Rand D., Wight A. E., Kim H. J., Liraz-Zaltsman S., Cooper I., Beeri M. S. & Cantor H. (2023), Proceedings of the National Academy of Sciences of the United States of America. 120, 6, e221891512
  • Phase II trial of hypomethylating agent combined with nivolumab for acute myeloid leukaemia relapse after allogeneic haematopoietic cell transplantation—Immune signature correlates with response

    Authors: Apostolova P., Kreutmair S., Toffalori C., Punta M., Unger S., Burk A. C., Wehr C., Maas-Bauer K., Melchinger W., Haring E., Hoefflin R., Shoumariyeh K., Hupfer V., Lauer E. M., Duquesne S., Lowinus T., Gonzalo Núñez N., Alberti C., da Costa Pereira S., Merten C. H., Power L., Weiss M., Böke C., Pfeifer D., Marks R., Bertz H., Wäsch R., Ihorst G., Gentner B., Duyster J., Boerries M., Andrieux G., Finke J., Becher B., Vago L. & Zeiser R. (2023), British Journal of Haematology. 203, 2, p. 264-281
  • Distinct spatiotemporal features of microglia and monocyte-derived macrophages in glioma

    Authors: Banerjee K., Ratzabi A., Caspit I. M., Ganon O., Blinder P., Jung S. & Stein R. (2023), European Journal of Immunology. e2250161
  • L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

    Authors: Marrocco I., Giri S., Simoni-Nieves A., Gupta N., Rudnitsky A., Haga Y., Romaniello D., Sekar A., Zerbib M., Oren R., Lindzen M., Fard D., Tsutsumi Y., Lauriola M., Tamagnone L. & Yarden Y. (2023), Cell Reports Medicine. 4, 8, 101142
  • Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

    Authors: Dasgupta S., Dayagi D. Y., Haimovich G., Wyler E., Olender T., Singer R. H., Landthaler M. & Gerst J. E. (2023), eLife. 12, e83584
  • Large-Scale Immuno-Peptidome Analysis Reveals Recurrent Post-Translational Splicing of Cancer and Immune-Associated Genes

    Authors: Levy R., Alter Regev T., Paes W., Gumpert N., Cohen Shvefel S., Bartok O., Dayan-Rubinov M., Alon M., Shmueli M., Levin Y., Merbl Y., Ternette N. & Samuels Y. (2023), Molecular & Cellular Proteomics. 22, 4, 100519
  • Arterial Thromboembolism in Patients With AF and CHA2DS2-VASc Score 0-2 With and Without Cancer

    Authors: Leader A., Mendelson Cohen N., Afek S., Jaschek R., Frajman A., Itzhaki Ben Zadok O., Raanani P., Lishner M. & Spectre G. (2023), JACC: CardioOncology. 5, 2, p. 174-185
  • Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours

    Authors: Gavish A., Tyler M., Greenwald A. C., Hoefflin R., Simkin D., Tschernichovsky R., Galili Darnell N., Somech E., Barbolin C., Antman T., Kovarsky D., Barrett T., Gonzalez Castro L. N., Halder D., Chanoch-Myers R., Laffy J., Mints M., Wider A., Tal R., Spitzer A., Hara T., Raitses-Gurevich M., Stossel C., Golan T., Tirosh A., Suvà M. L., Puram S. V. & Tirosh I. (2023), Nature. 618, 7965, p. 598-606
  • Shearing of surface mucin saps tumor cell strength

    Authors: Greenberg L. J. & Fass D. (2023), Trends in Pharmacological Sciences. 44, 11, p. 755-757
  • Probing lipids relaxation times in breast cancer using magnetic resonance spectroscopic fingerprinting

    Authors: Nissan N., Kulpanovich A., Agassi R., Allweis T., Haas I., Carmon E., Furman-Haran E., Anaby D., Sklair-Levy M. & Tal A. (2023), European Radiology. 33, p. 3744-3753
  • Neoantigens in cancer immunotherapy: quantity vs. quality

    Authors: Wolf Y. & Sameuls Y. (2023), Molecular Oncology. 17, 8, p. 1457-1459
  • Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

    Authors: Kotsiliti E., Leone V., Schuehle S., Govaere O., Li H., Wolf M. J., Horvatic H., Bierwirth S., Hundertmark J., Inverso D., Zizmare L., Sarusi-Portuguez A., Gupta R., O'Connor T., Giannou A. D., Shiri A. M., Schlesinger Y., Beccaria M. G., Rennert C., Pfister D., Öllinger R., Gadjalova I., Ramadori P., Rahbari M., Rahbari N., Healy M. E., Fernández-Vaquero M., Yahoo N., Janzen J., Singh I., Fan C., Liu X., Rau M., Feuchtenberger M., Schwaneck E., Wallace S. J., Cockell S., Wilson-Kanamori J., Ramachandran P., Kho C., Kendall T. J., Leblond A. L., Keppler S. J., Bielecki P., Steiger K., Hofmann M., Rippe K., Zitzelsberger H., Weber A., Malek N., Luedde T., Vucur M., Augustin H. G., Flavell R., Parnas O., Rad R., Pabst O., Henderson N. C., Huber S., Macpherson A., Knolle P., Claassen M., Geier A., Trautwein C., Unger K., Elinav E., Waisman A., Abdullah Z., Haller D., Tacke F., Anstee Q. M. & Heikenwalder M. (2023), Journal of Hepatology. 79, 2, p. 296-313
  • MYC induces immunotherapy and interferon-γ resistance through downregulation of JAK2

    Authors: Markovits E., Harush O., Baruch E. N., Shulman E. D., Debby A., Itzhaki O., Anafi L., Danilevsky A., Shomron N., Ben-Betzalel G., Asher N., Shapira-Frommer R., Schachter J., Barshack I., Geiger T., Elkon R., Besser M. J. & Markel G. (2023), Cancer Immunology Research.
  • Green Synthesis of Silver Nanoparticles Using the Leaf Extract of the Medicinal Plant, Uvaria narum and Its Antibacterial, Antiangiogenic, Anticancer and Catalytic Properties

    Authors: Ajaykumar A. P., Mathew A., Chandni A. P., Varma S. R., Jayaraj K. N., Sabira O., Rasheed V. A., Binitha V. S., Swaminathan T. R., Basheer V. S., Giri S. & Chatterjee S. (2023), Antibiotics. 12, 3, 564
  • Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation

    Authors: Saltarin F., Wegmüller A., Bejarano L., Ildiz E. S., Zwicky P., Vianin A., Spadin F., Soukup K., Wischnewski V., Engelhardt B., Deutsch U., J. Marques I., Frenz M., Joyce J. A. & Lyck R. (2023), Cancers. 15, 20, 5071
  • Mutually communicated model based on multi-parametric MRI for automated segmentation and classification of prostate cancer

    Authors: Liu K., Li P., Otikovs M., Ning X., Xia L., Wang X., Yang L., Pan F., Zhang Z., Wu G., Xie H., Bao Q., Zhou X. & Liu C. (2023), Medical Physics. 50, 6, p. 3445-3458
  • RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer

    Authors: Jbara A., Lin K. T., Stossel C., Siegfried Z., Shqerat H., Amar-Schwartz A., Elyada E., Mogilevsky M., Raitses-Gurevich M., Johnson J. L., Yaron T. M., Ovadia O., Jang G. H., Danan-Gotthold M., Cantley L. C., Levanon E. Y., Gallinger S., Krainer A. R., Golan T. & Karni R. (2023), Nature. 617, 7959, p. 147-153
  • Targeted delivery of tumor necrosis factor in combination with CCNU induces a T cell-dependent regression of glioblastoma

    Authors: Look T., Puca E., Bühler M., Kirschenbaum D., De Luca R., Stucchi R., Ravazza D., Di Nitto C., Roth P., Katzenelenbogen Y., Weiner A., Rindlisbacher L., Becher B., Amit I., Weller M., Neri D., Hemmerle T. & Weiss T. (2023), Science Translational Medicine. 15, 697, p. eadf2281
  • Relaxation–Diffusion T2–ADC Correlations in Breast Cancer Patients: A Spatiotemporally Encoded 3T MRI Assessment

    Authors: Otikovs M., Nissan N., Furman-Haran E., Anaby D., Agassi R., Sklair-Levy M. & Frydman L. (2023), Diagnostics. 13, 23, 3516
  • The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors

    Authors: Dougherty M. W., Valdés-Mas R., Wernke K. M., Gharaibeh R. Z., Yang Y., Brant J. O., Riva A., Muehlbauer M., Elinav E., Puschhof J., Herzon S. B. & Jobin C. (2023), Neoplasia (United States). 43, 100918
  • EMSY stabilization in KEAP1-mutant lung cancer disrupts genome stability and type I interferon signaling

    Authors: Sheban D. & Merbl Y. (2023),
  • It takes two to tango: the role of tumor-associated macrophages in T cell-directed immune checkpoint blockade therapy

    Authors: Sheban F. (2023), Frontiers in Immunology. 14, 1183578
  • Cerebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis

    Authors: Räuber S., Schroeter C. B., Strippel C., Nelke C., Ruland T., Dik A., Golombeck K. S., Regner-Nelke L., Paunovic M., Esser D., Münch C., Rosenow F., van Duijn M., Henes A., Ruck T., Amit I., Leypoldt F., Titulaer M. J., Wiendl H., Meuth S. G., Meyer zu Hörste G. & Melzer N. (2023), Journal of Autoimmunity. 135, 102985
  • Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting

    Authors: Stossel C., Raitses-Gurevich M., Atias D., Beller T., Glick Gorman Y., Halperin S., Peer E., Denroche R. E., Zhang A., Notta F., Wilson J. M., O'Kane G. M., Haimov Talmoud E., Amison N., Schvimer M., Salpeter S. J., Bar V., Zundelevich A., Tirosh I., Tal R., Dinstag G., Kinar Y., Eliezer Y., Ben-David U., Gavert N. S., Straussman R., Gallinger S. J., Berger R. & Golan T. (2023), Cancer Discovery. 13, 8, p. 1826-1843
  • Multiplexed, single-molecule, epigenetic analysis of plasma-isolated nucleosomes for cancer diagnostics

    Authors: Fedyuk V., Erez N., Furth N., Beresh O., Andreishcheva E. N., Shinde A., Jones D., Bar Zakai B., Mavor Y., Peretz T., Hubert A., Cohen J., Salah A., Temper M., Grinshpun A., Maoz M., Zick A., Ron G. & Shema E. (2023), Nature Biotechnology. 41, 2, p. 212-221
  • Unanswered questions in prostate cancer - findings of an international multi-stakeholder consensus by the PIONEER consortium

    Authors: Omar M. I., MacLennan S., Ribal M. J., Roobol M. J., Dimitropoulos K., van den Broeck T., MacLennan S. J., Axelsson S. E., Gandaglia G., Willemse P., Mastris K., Ransohoff J. B., Devecseri Z., Abbott T., De Meulder B., Bjartell A., Asiimwe A., N'Dow J., Smith E., Lancet D. & Bernstein G. (2023), Nature Reviews Urology. 20, 8, p. 494-501
  • The tumor microenvironment shows a hierarchy of cell-cell interactions dominated by fibroblasts

    Authors: Mayer S., Milo T., Isaacson A., Halperin C., Miyara S., Stein Y., Lior C., Pevsner-Fischer M., Tzahor E., Mayo A., Alon U. & Scherz-Shouval R. (2023), Nature Communications. 14, 1, 5810
  • CAR-T Cell Therapy and the Gut Microbiota

    Authors: Asokan S., Cullin N., Stein-Thoeringer C. K. & Elinav E. (2023), Cancers. 15, 3, 794
  • The landscape of T cell antigens for cancer immunotherapy

    Authors: Peri A., Salomon N., Wolf Y., Kreiter S., Diken M. & Samuels Y. (2023), Nature Cancer. 4, 7, p. 937-954
  • Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma

    Authors: Puram S. V., Mints M., Pal A., Qi Z., Reeb A., Gelev K., Barrett T. F., Gerndt S., Liu P., Parikh A. S., Ramadan S., Law T., Mroz E. A., Rocco J. W., Adkins D., Thorstad W. L., Gay H. A., Ding L., Paniello R. C., Pipkorn P., Jackson R. S., Wang X., Mazul A., Chernock R., Zevallos J. P., Silva-Fisher J. & Tirosh I. (2023), Nature Genetics. 55, 4, p. 640-650
  • Immunometabolism at the crossroads of obesity and cancer—a Keystone Symposia report

    Authors: Cable J., Rathmell J. C., Pearce E. L., Ho P. C., Haigis M. C., Mamedov M. R., Wu M. J., Kaech S. M., Lynch L., Febbraio M. A., Bapat S. P., Hong H. S., Zou W., Belkaid Y., Sullivan Z. A., Keller A., Wculek S. K., Green D. R., Postic C., Amit I., Benitah S. A., Jones R. G., Reina-Campos M., Torres S. V., Beyaz S., Brennan D., O'Neill L. A., Perry R. J. & Brenner D. (2023), Annals of the New York Academy of Sciences. 1523, 1, p. 38-50
  • Intracellular bacteria in cancer—prospects and debates

    Authors: Schorr L., Mathies M., Elinav E. & Puschhof J. (2023), npj Biofilms and Microbiomes. 9, 76
  • Functional Impact of Protein-RNA Variation in Clinical Cancer Analyses

    Authors: Arad G. & Geiger T. (2023), Molecular & cellular proteomics : MCP. 22, 7, 100587
  • Depleting the 19S proteasome regulatory PSMD1 subunit as a cancer therapy strategy

    Authors: Adler J., Oren R. & Shaul Y. (2023), Cancer medicine (Malden, MA).
  • A Novel Modality Enables New Evidence-Based Individual Risk Stratification That Can Potentially Lead to Decisive Management and Treatment Decisions in Prostate Cancer

    Authors: Weksler M., Simon A., Lenkinski R. E., Landsman H., Matzkin H., Mabjeesh N. & Leibovitch I. (2023), Diagnostics. 13, 3, 424
  • The prognostic value of beta-1 blockers in patients with non-small-cell lung carcinoma treated with pembrolizumab

    Authors: Leshem Y., Etan T., Dolev Y., Nikolaevski-Berlin A., Miodovnik M., Shamai S., Merimsky O., Wolf I., Havakuk O., Tzuberi M., Topilsky Y., Banai S., Rozenbaum Z. & Laufer-Perl M. (2023), International Journal of Cardiology. 131642
  • Resistance of Lung Cancer to EGFR-Specific Kinase Inhibitors: Activation of Bypass Pathways and Endogenous Mutators

    Authors: Marrocco I. & Yarden Y. (2023), Cancers. 15, 20, 5009
  • Folylpolyglutamate synthetase mRNA G-quadruplexes regulate its cell protrusion localization and enhance a cancer cell invasive phenotype upon folate repletion

    Authors: Stark M., Levin M., Ulitsky I. & Assaraf Y. G. (2023), BMC Biology. 21, 1, 13
  • UV irradiation remodels the specificity landscape of transcription factors

    Authors: Mielko Z., Zhang Y., Sahay H., Liu Y., Schaich M. A., Schnable B., Morrison A. M., Burdinski D., Adar S., Pufall M., Van Houten B., Gordân R. & Afek A. (2023), Proceedings of the National Academy of Sciences of the United States of America. 120, 11, e221742212
  • A natural goldmine of binding proteins and soluble receptors simplified their translation to blockbuster drugs, all in one decade

    Authors: Novick D. (2023),
  • Glioma synapses recruit mechanisms of adaptive plasticity

    Authors: Taylor K. R., Barron T., Hui A., Spitzer A., Yalçin B., Ivec A. E., Geraghty A. C., Hartmann G. G., Arzt M., Gillespie S. M., Kim Y. S., Maleki Jahan S., Zhang H., Shamardani K., Su M., Ni L., Du P. P., Woo P. J., Silva-Torres A., Venkatesh H. S., Mancusi R., Ponnuswami A., Mulinyawe S., Keough M. B., Chau I., Aziz-Bose R., Tirosh I., Suvà M. L. & Monje M. (2023), Nature. 623, 7986, p. 366-374
  • Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology

    Authors: Bolshette N., Ibrahim H., Reinke H. & Asher G. (2023), Nature Reviews Gastroenterology and Hepatology. 20, 11, p. 695-707
  • Fungi and cancer

    Authors: Saftien A., Puschhof J. & Elinav E. (2023), Gut. 72, 7, p. 1410-1425
  • Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary

    Authors: Yofe I., Shami T., Cohen N., Landsberger T., Sheban F., Stoler-Barak L., Yalin A., Phan T. S., Li B., Monteran L., Scharff Y., Giladi A., Elbaz M., David E., Gurevich-Shapiro A., Gur C., Shulman Z., Erez N. & Amit I. (2023), Cancer Discovery. 13, 12, p. 2610-2631
  • A Highly Sensitive Flow Cytometric Approach to Detect Rare Antigen-Specific T Cells: Development and Comparison to Standard Monitoring Tools

    Authors: Dror Levinsky M., Brenner B., Yalon M., Levi Z., Livneh Z., Cohen Z., Paz-Elizur T., Grossman R., Ram Z. & Volovitz I. (2023), Cancers. 15, 3, 574
  • The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC

    Authors: Javitt A., Shmueli M. D., Kramer M. P., Kolodziejczyk A. A., Cohen I. J., Radomir L., Sheban D., Kamer I., Litchfield K., Bab-Dinitz E., Zadok O., Neiens V., Ulman A., Wolf-Levy H., Eisenberg-Lerner A., Kacen A., Alon M., Rêgo A. T., Stacher-Priehse E., Lindner M., Koch I., Bar J., Swanton C., Samuels Y., Levin Y., da Fonseca P. C., Elinav E., Friedman N., Meiners S. & Merbl Y. (2023), Nature Cancer. 4, 5, p. 629-647
  • Paradoxical activation of chronic lymphocytic leukemia cells by ruxolitinib in vitro and in vivo

    Authors: Spaner D. E., Luo T. Y. X., Wang G., Schreiber G., Harari D. & Shi Y. (2023), Frontiers in Oncology. 13, 1043694
  • Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency

    Authors: Rein A., Geron I., Kugler E., Fishman H., Gottlieb E., Abramovich I., Giladi A., Amit I., Mulet-Lazaro R., Delwel R., Gröschel S., Levin-Zaidman S., Dezorella N., Holdengreber V., Rao T. N., Yacobovich J., Steinberg-Shemer O., Huang Q., Tan Y., Chen S., Izraeli S. & Birger Y. (2023), Haematologica (Roma). 108, 9, p. 2316-2330
  • Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy

    Authors: Cohen Saban N., Yalin A., Landsberger T., Salomon R., Alva A., Feferman T., Amit I. & Dahan R. (2023), Science immunology. 8, 81, eadd8005
  • PYK2, a hub of signaling networks in breast cancer progression

    Authors: Gil-Henn H., Girault J. A. & Lev S. (2023), Trends in Cell Biology. 34, 4, p. 312-326
  • Identification of Lung Cancer Biomarkers by Nanosensors Based on Titanium Carbide (Ti3C2Tx) MXenes

    Authors: Panigrahi P., Vovusha H., Pal Y., Bae H., Lee H., Kaewmaraya T., Nazir S., Shiddiky M. J. & Hussain T. (2023), ACS Applied Nano Materials. 6, 23, p. 22117-22127
  • Computational design of BclxL inhibitors that target transmembrane domain interactions

    Authors: Duart G., Elazar A., Weinstein J. Y., Gadea-Salom L., Ortiz-Mateu J., Fleishman S. J., Mingarro I. & Martinez-Gil L. (2023), Proceedings of the National Academy of Sciences - PNAS. 120, 11, p. e2219648120-e2219648120
  • TAZ facilitates breast tumor growth by promoting an immune-suppressive tumor microenvironment

    Authors: Gershoni A., Hassin O., Nataraj N. B., Baruch S., Avioz-Seligman A., Pirona A. C., Fellus-Alyagor L., Meir Salame T., Mukherjee S., Mallel G., Yarden Y., Aylon Y. & Oren M. (2023), Molecular Oncology. 17, 12, p. 2675-2693
  • A single-molecule liquid biopsy for cancer diagnosis

    Authors: Shema E. (2023),
  • Tackling tumor complexity with single-cell proteomics

    Authors: Geiger T. (2023), Nature Methods. 20, 3, p. 324-326
  • Clinical trial links oncolytic immunoactivation to survival in glioblastoma

    Authors: Ling A. L., Solomon I. H., Landivar A. M., Nakashima H., Woods J. K., Santos A., Masud N., Fell G., Mo X., Yilmaz A. S., Grant J., Zhang A., Bernstock J. D., Torio E., Ito H., Liu J., Shono N., Nowicki M. O., Triggs D., Halloran P., Piranlioglu R., Soni H., Stopa B., Bi W. L., Peruzzi P., Chen E., Malinowski S. W., Prabhu M. C., Zeng Y., Carlisle A., Rodig S. J., Wen P. Y., Lee E. Q., Nayak L., Chukwueke U., Gonzalez Castro L. N., Dumont S. D., Batchelor T., Kittelberger K., Tikhonova E., Miheecheva N., Tabakov D., Shin N., Gorbacheva A., Shumskiy A., Frenkel F., Aguilar-Cordova E., Aguilar L. K., Krisky D., Wechuck J., Manzanera A., Matheny C., Tak P. P., Barone F., Kovarsky D., Tirosh I., Suvà M. L., Wucherpfennig K. W., Ligon K., Reardon D. A. & Antonio Chiocca E. (2023), Nature. 623, 7985, p. 157-166
  • Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis

    Authors: Goldman O., Adler L. N., Hajaj E., Croese T., Darzi N., Galai S., Tishler H., Ariav Y., Lavie D., Fellus-Alyagor L., Oren R., Kuznetsov Y., David E., Jaschek R., Stossel C., Singer O., Malitsky S., Barak R., Seger R., Erez N., Amit I., Tanay A., Saada A., Golan T., Rubinek T., Sang Lee J., Ben-Shachar S., Wolf I. & Erez A. (2023), Cancer Discovery. 13, 7, p. 1616-1635
  • Targeting ribosome biogenesis reinforces ERK-dependent senescence in pancreatic cancer

    Authors: Rowell M. C., Deschênes-Simard X., Lopes-Paciencia S., Le Calvé B., Kalegari P., Mignacca L., Fernandez-Ruiz A., Guillon J., Lessard F., Bourdeau V., Igelmann S., Duman A. M., Stanom Y., Kottakis F., Deshpande V., Krizhanovsky V., Bardeesy N. & Ferbeyre G. (2023), Cell Cycle. 22, 19, p. 2172-2193
  • Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy

    Authors: Ma G. & Lin W. (2023), Military Medical Research. 10, 20
  • Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis

    Authors: Light N., Layeghifard M., Attery A., Subasri V., Zatzman M., Anderson N. D., Hatkar R., Blay S., Chen D., Novokmet A., Fuligni F., Tran J., de Borja R., Agarwal H., Waldman L., Abegglen L. M., Albertson D., Finlay J. L., Hansford J. R., Behjati S., Villani A., Gerstung M., Alexandrov L. B., Somers G. R., Schiffman J. D., Rotter V., Malkin D. & Shlien A. (2023), Nature Communications. 14, 1, 77
  • The C-terminal tail of CSNAP attenuates the CSN complex

    Authors: Füzesi-Levi M. G., Ben-Nissan G., Listov D., Fridmann Sirkis Y., Hayouka Z., Fleishman S. & Sharon M. (2023), Life Science Alliance. 6, 10, e202201634
  • How Well do Polygenic Risk Scores Identify Men at High Risk for Prostate Cancer? Systematic Review and Meta-Analysis

    Authors: Siltari A., Lönnerbro R., Pang K., Shiranov K., Asiimwe A., Evans-Axelsson S., Franks B., Kiran A., Murtola T. J., Schalken J., Steinbeisser C., Bjartell A., Auvinen A., N'Dow J., Smith E. J., Shepherd R., Ribal M., Mottet N., Moris L. & Lancet D. (2023), Clinical Genitourinary Cancer. 21, 2, p. 316.e1-316.e11
  • An Increase in Mucin2 Expression Is Required for Colon Cancer Progression Mediated by L1

    Authors: Saha A., Gavert N., Brabletz T. & Ben-Ze’ev A. (2023), International Journal of Molecular Sciences. 24, 17, 13418
  • Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis

    Authors: Tsitsou-Kampeli A., Suzzi S., Kenigsbuch M., Satomi A., Strobelt R., Singer O., Feldmesser E., Purnapatre M., Colaiuta S. P., David E., Cahalon L., Hahn O., Wyss-Coray T., Shaul Y., Amit I. & Schwartz M. (2023), Cell Reports Medicine. 4, 11, 101278
  • Integrative study of whole exome variation and expression in gingivo-buccal oral squamous cell carcinoma revealed alteration in TLR-activated MAP-Kinase signalling

    Authors: Singh R., Chattopadhyay E., Ray A., Roy R., Biswas N. K., Ghose S. & Roy B. (2023), Human Gene. 36, 201183
  • TRAF3 suppression encourages B cell recruitment and prolongs survival of microbiome-intact mice with ovarian cancer

    Authors: Zorea J., Motro Y., Mazor R. D., Carmi Y. K., Shulman Z., Mahajna J., Moran-Gilad J. & Elkabets M. (2023), Journal of Experimental and Clinical Cancer Research. 42, 107
  • Clonal evolution of leukemia from G6PD studies

    Authors: Bacharach T. & Shlush L. I. (2023), Haematologica. 108, 12, p. 3191-3192
  • Trapping all ERBB ligands decreases pancreatic lesions in a murine model of pancreatic ductal adenocarcinoma

    Authors: Hedegger K., Blutke A., Hommel T., Auer K. E., Nataraj N. B., Lindzen M., Yarden Y. & Dahlhoff M. (2023), Molecular Oncology.
  • Insights into the co-evolution of epithelial cells and fibroblasts in the esophageal tumor microenvironment

    Authors: Lavon H. & Scherz-Shouval R. (2023), Cancer Cell. 41, 5, p. 826-828
  • From gatekeepers to providers: regulation of immune functions by cancer-associated fibroblasts

    Authors: Arpinati L. & Scherz-Shouval R. (2023), Trends in Cancer. 9, 5, p. 421-443
  • αβ+/CD19+-depleted haploidentical stem cell transplantation for children with acute leukemia: Is there a protective effect of increased γδ+ T-cell content in the graft?

    Authors: Dadi G., Jacoby E., Adam E., Hutt D., Varda-Bloom N., Bielorai B. & Toren A. (2023), Pediatric Transplantation. 27, 5, e14531
  • Association between diabetes mellitus and reduced efficacy of pembrolizumab in non–small cell lung cancer

    Authors: Leshem Y., Dolev Y., Siegelmann-Danieli N., Sharman Moser S., Apter L., Chodick G., Nikolaevski-Berlin A., Shamai S., Merimsky O. & Wolf I. (2023), Cancer.
  • Capturing the diversity of protein modifications on presented tumor antigens

    Authors: Javitt A. & Merbl Y. (2023), Nature biotechnology. 41, 2, p. 195-196
  • p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells

    Authors: Hassin O., Sernik M., Seligman A., Vogel F. C., Wellenstein M. D., Smollich J., Halperin C., Pirona A. C., Toledano L. N., Caballero C. D., Schlicker L., Salame T. M., Portuguez A. S., Aylon Y., Scherz-Shouval R., Geiger T., de Visser K. E., Schulze A. & Oren M. (2023), Proceedings of the National Academy of Sciences of the United States of America. 120, 52, e231146012
  • Final Results of a Phase i Trial of WST-11 (TOOKAD Soluble) Vascular-targeted Photodynamic Therapy for Upper Tract Urothelial Carcinoma

    Authors: Yip W., Sjoberg D. D., Nogueira L. M., Tracey A. T., Alvim R. G., Reisz P. A., Demac Q., Benfante N. E., Vanden Berg R. W., Kim K., Al-Ahmadie H., Lin O., Bochner B. H., Dalbagni G., Donat S. M., Pietzak E. J., Hakimi A. A., Solit D. B., Scherz A., Bajorin D. F. & Coleman J. A. (2023),
  • Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors

    Authors: Kacen A., Javitt A., Kramer M. P., Morgenstern D., Tsaban T., Shmueli M. D., Teo G. C., Leprevost F. d. V., Barnea E., Yu F., Admon A., Eisenbach L., Samuels Y., Schueler-Furman O., Levin Y., Nesvizhskii A. & Merbl Y. (2023), Nature Biotechnology. 41, 2, p. 239-251
  • The proteasome regulator PSME4 drives immune evasion and abrogates anti-tumor immunity in NSCLC

    Authors: Javitt A., Shmueli M., Kramer M., Kolodziejczyk A., Cohen I., Kamer I., Litchfield K., Bab-Dinitz E., Zadok O., Neiens V., Ulman A., Radomir L., Wolf-Levy H., Eisenberg-Lerner A., Kacen A., Alon M., Toste Rêgo A., Stacher-Priehse E., Lindner M., Koch I., Bar J., Swanton C., Samuels Y., Levin Y., da Fonseca P. C. A., Elinav E., Friedman N., Meiners S. & Merbl Y. (2023), bioArxiv.
  • Modulating the proliferative and cytotoxic properties of patient-derived TIL by a synthetic immune niche of immobilized CCL21 and ICAM1

    Authors: Yunger S., Geiger B., Friedman N., Besser M. J. & Adutler-Lieber S. (2023), Frontiers in Oncology. 13, 1116328
  • BBB opening by low pulsed electric fields, depicted by delayed-contrast MRI, enables efficient delivery of therapeutic doxorubicin doses into mice brains

    Authors: Cooper I., Last D., Ravid O., Rand D., Matsree E., Omesi L., Shemesh C., Liberman M., Zach L., Furman O., Daniels D., Liraz-Zaltsman S., Mardor Y. & Sharabi S. (2023), Fluids and Barriers of the CNS. 20, 1, 67
  • Impact of TP53 Genomic Alterations in Large B-Cell Lymphoma Treated With CD19-Chimeric Antigen Receptor T-Cell Therapy

    Authors: Shouval R., Alarcon Tomas A., Fein J. A., Flynn J. R., Markovits E., Mayer S., Olaide Afuye A., Alperovich A., Anagnostou T., Besser M. J., Batlevi C. L., Dahi P. B., Devlin S. M., Fingrut W. B., Giralt S. A., Lin R. J., Markel G., Salles G., Sauter C. S., Scordo M., Shah G. L., Shah N., Scherz-Shouval R., van den Brink M., Perales M. & Palomba M. L. (2022), Journal of Clinical Oncology. 40, 4, p. 369-381
  • Cancer and cell cycle

    Authors: Nair R. R. & Yadav S. S. (2022), Understanding Cancer. Jain B. & Pandey S. (eds.). p. 91-102
  • Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

    Authors: Sciacovelli M., Dugourd A., Jimenez L. V., Yang M., Nikitopoulou E., Costa A. S. H., Tronci L., Caraffini V., Rodrigues P., Schmidt C., Ryan D. G., Young T., Zecchini V. R., Rossi S. H., Massie C., Lohoff C., Masid M., Hatzimanikatis V., Kuppe C., Kramann R., Von Kriegsheim A., Gnanapragasam V., Warren A. Y., Stewart G. D., Erez A., Vanharanta S., Saez-Rodriguez J. & Frezza C. (2022), Nature Communications. 13, 1, 7830
  • Bispecific antibodies increase the therapeutic window of CD40 agonists through selective dendritic cell targeting

    Authors: Salomon R., Rotem H., Katzenelenbogen Y., Weiner A., Cohen Saban N., Feferman T., Amit I. & Dahan R. (2022), Nature Cancer. 3, p. 287-302
  • Next Generation CD40 Agonistic Antibodies for Cancer Immunotherapy

    Authors: Salomon R. & Dahan R. (2022), Frontiers in Immunology. 13, 940674
  • ICAM-1 on Breast Cancer Cells Suppresses Lung Metastasis but Is Dispensable for Tumor Growth and Killing by Cytotoxic T Cells

    Authors: Regev O., Kizner M., Roncato F., Dadiani M., Saini M., Castro-Giner F., Yajuk O., Kozlovski S., Levi N., Addadi Y., Golani O., Ben-Dor S., Granot Z., Aceto N. & Alon R. (2022), Frontiers in Immunology. 13, 849701
  • Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through FcγR engagement and type I interferon signaling

    Authors: Yofe I., Landsberger T., Yalin A., Solomon I., Costoya C., Demane D. F., Shah M., David E., Borenstein C., Barboy O., Matos I., Peggs K. S., Quezada S. A. & Amit I. (2022), Nature Cancer. 3, p. 1336-1350
  • Cancer microbiome

    Authors: Zitvogel L., Straussman R., Sepich-Poore G. D., Knight R., Iliev I. D., Sears C. L., Bullman S., Jobin C. & Zarour H. M. (2022), Cancer Cell. 40, 12, p. 1443-1447
  • Tumor-reactive antibodies evolve from non-binding and autoreactive precursors

    Authors: Mazor R. D., Nathan N., Gilboa A., Stoler-Barak L., Moss L., Solomonov I., Hanuna A., Divinsky Y., Shmueli M. D., Hezroni H., Zaretsky I., Mor M., Golani O., Sabah G., Jakobson-Setton A., Yanichkin N., Feinmesser M., Tsoref D., Salman L., Yeoshoua E., Peretz E., Erlich I., Mendelson Cohen N., Gershoni J. M., Freund N., Merbl Y., Yaari G., Eitan R., Sagi I. & Shulman Z. (2022), Cell. 185, 7, p. 1208-1222
  • A new function for the serine protease HtrA2 in controlling radiation-induced senescence in cancer cells

    Authors: Hammer L., Levin-Salomon V., Yaeli-Slonim N., Weiss M., Dekel-Bird N. P., Olender T., Porat Z., Winograd-Katz S., Savidor A., Levin Y., Bialik S., Geiger B. & Kimchi A. (2022), Molecular Oncology. 16, 6
  • Elucidating the diversity of malignant mesenchymal states in glioblastoma by integrative analysis

    Authors: Chanoch-Myers R., Wider A., Suva M. L. & Tirosh I. (2022), Genome Medicine. 14, 1, 106
  • DestVI identifies continuums of cell types in spatial transcriptomics data

    Authors: Lopez R., Li B., Keren-Shaul H., Boyeau P., Kedmi M., Pilzer D., Jelinski A., Yofe I., David E., Wagner A., Ergen C., Addadi Y., Golani O., Ronchese F., Jordan M. I., Amit I. & Yosef N. (2022), Nature biotechnology. 40, 9, p. 1360-1369
  • Targeted Drug Delivery for the Treatment of Blood Cancers

    Authors: Jiang Y., Lin W. & Zhu L. (2022), Molecules (Basel, Switzerland). 27, 4, 1310
  • Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors

    Authors: Belugali Nataraj N., Noronha A., Lee J. S., Ghosh S., Mohan Raju H. R., Sekar A., Zuckerman B., Lindzen M., Tarcitano E., Srivastava S., Selitrennik M., Livneh I., Drago-Garcia D., Rueda O. M., Caldas C., Lev S., Geiger T., Ciechanover A., Ulitsky I., Seger R., Ruppin E. & Yarden Y. (2022), Cell Reports. 38, 8, 110418
  • Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis

    Authors: Aylon Y., Furth N., Mallel G., Friedlander G., Nataraj N. B., Dong M., Hassin O., Zoabi R., Cohen B., Drendel V., Salame T. M., Mukherjee S., Harpaz N., Johnson R., Aulitzky W. E., Yarden Y., Shema E. & Oren M. (2022), Nature Communications. 13, 1, 7199
  • Pseudo-mutant P53 is a unique phenotype of DNMT3Amutated pre-leukemia

    Authors: Tuval A., Brilon Y., Azogy H., Moskovitz Y., Leshkowitz D., Salame T. M., Minden M. D., Tal P., Rotter V., Oren M., Kaushansky N. & Shlush L. I. (2022), Haematologica. 107, 11, p. 2548-2561
  • Proteomic signature for detection of high-grade ovarian cancer in germline BRCA mutation carriers

    Authors: Bahar-Shany K., Barnabas G. D., Deutsch L., Deutsch N., Glick-Saar E., Dominissini D., Sapoznik S., Helpman L., Perri T., Blecher A., Katz G., Yagel I., Rosenblatt O., Shai D., Brandt B., Meyer R., Mohr-Sasson A., Volodarsky-Perel A., Zilberman I., Armon S., Jakobson-Setton A., Eitan R., Kadan Y., Beiner M., Josephy D., Brodsky M., Friedman E., Anafi L., Molchanov Y., Korach J., Geiger T. & Levanon K. (2022), International Journal of Cancer. 152, 4, p. 781-793
  • BREAst Cancer Personalised NuTrition (BREACPNT): dietary intervention in breast cancer survivors treated with endocrine therapy – a protocol for a randomised clinical trial

    Authors: Rein M. S., Dadiani M., Godneva A., Bakalenik-Gavry M., Morzaev-Sulzbach D., Vachnish Y., Kolobkov D., Lotan-Pompan m., Weinberger A., Segal E. & Gal-Yam E. N. (2022), BMJ Open. 12, 11, e062498
  • Aptamer-Modified Au Nanoparticles: Functional Nanozyme Bioreactors for Cascaded Catalysis and Catalysts for Chemodynamic Treatment of Cancer Cells

    Authors: Ouyang Y., Fadeev M., Zhang P., Carmieli R., Li J., Sohn Y. S., Karmi O., Nechushtai R., Pikarsky E., Fan C. & Willner I. (2022), ACS Nano. 16, 11, p. 18232-18243
  • Mechanisms of immune activation and regulation: lessons from melanoma

    Authors: Kalaora S., Nagler A., Wargo J. A. & Samuels Y. (2022), Nature reviews. Cancer. 22, 4, p. 195-207
  • A necessary role for increased biglycan expression during L1‐mediated colon cancer progression

    Authors: Saha A., Cheriyamundath S., Kumar A., Gavert N., Brabletz T. & Ben-Ze'ev A. (2022), International Journal of Molecular Sciences. 23, 1, 445
  • Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions

    Authors: Kolodkin-Gal D., Roitman L., Ovadya Y., Azazmeh N., Assouline B., Schlesinger Y., Kalifa R., Horwitz S., Khalatnik Y., Hochner-Ger A., Imam A., Demma J. A., Winter E., Benyamini H., Elgavish S., Khatib A. A., Meir K., Atlan K., Pikarsky E., Parnas O., Dor Y., Zamir G., Ben-Porath I. & Krizhanovsky V. (2022), Gut. 71, 2, p. 345-355
  • ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells

    Authors: Fishman H., Madiwale S., Geron I., Bari V., Van Loocke W., Kirschenbaum Y., Ganmore I., Kugler E., Rein-Gil A., Friedlander G., Schiby G., Birger Y., Strehl S., Soulier J., Knoechel B., Ferrando A., Noy-Lotan S., Nagler A., Mulloy J. C., Van Vlierberghe P. & Izraeli S. (2022), Blood. 139, 3, p. 399-412
  • The industrial genomic revolution: A new era in neuroimmunology

    Authors: Shalita R. & Amit I. (2022), Neuron (Cambridge, Mass.). 110, 21, p. 3429-3443
  • NRas activity is regulated by dynamic interactions with nanoscale signaling clusters at the plasma membrane

    Authors: Yakovian O., Sajman J., Alon M., Arafeh R., Samuels Y. & Sherman E. (2022), iScience. 25, 11, 105282
  • Comparing Intraperitoneal and Intravenous Personalized ErbB2CAR-T for the Treatment of Epithelial Ovarian Cancer

    Authors: Deshet-Unger N., Horn G., Rawet-Slobodkin M., Waks T., Laskov I., Michaan N., Raz Y., Bar V., Zundelevich A., Aharon S., Turovsky L., Mallel G., Salpeter S., Neev G., Hollander K. S., Katz B. Z., Grisaru D. & Globerson Levin A. (2022), Biomedicines. 10, 9, 2216
  • Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant

    Authors: Eytan K., Versano Z., Oren R., Jacob-Hirsch J., Leitner M., Harmelin A., Rechavi G., Toren A., Paglin S. & Yalon M. (2022), Frontiers in Oncology. 12, 959133
  • Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression

    Authors: Porazzi P., Petruk S., Pagliaroli L., De Dominici M., Deming, 2nd D., Puccetti M. V., Kushinsky S., Kumar G., Minieri V., Barbieri E., Deliard S., Trizzino M., Gardini A., Canaani E., Palmisiano N., Porcu P., Ertel A., Fortina P., Eischen C. M., Mazo A. & Calabretta B. (2022), Cancer Research. 82, 3, p. 458-471
  • Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells

    Authors: Wallis N., Oberman F., Shurrush K., Germain N., Greenwald G., Gershon T., Pearl T., Abis G., Singh V., Singh A., Sharma A. K., Barr H. M., Ramos A., Spiegelman V. S. & Yisraeli J. K. (2022), RNA Biology. 19, 1, p. 26-43
  • De novo-designed transmembrane domains tune engineered receptor functions

    Authors: Elazar A., Chandler N. J., Davey A. S., Weinstein J. Y., Nguyen J. V., Trenker R., Cross R. S., Jenkins M. R., Call M. J., Call M. E. & Fleishman S. J. (2022), eLife. 11, e75660
  • DNA methylation landscape of tumor-associated macrophages reveals pathways, transcription factors, and prognostic value relevant to triple-negative breast cancer patients

    Authors: Hey J., Halperin C., Hartmann M., Mayer S., Schönung M., Lipka D. B., Scherz-Shouval R. & Plass C. (2022), International Journal of Cancer.
  • Downregulation of the Tumor Suppressor TFF1 Is Required during Induction of Colon Cancer Progression by L1

    Authors: Saha A., Gavert N., Brabletz T. & Ben-Ze'ev A. (2022), Cancers. 14, 18, 4478
  • Di-genic inheritance of germline POLE and PMS2 pathogenic variants causes a unique condition associated with pediatric cancer predisposition

    Authors: Michaeli O., Ladany H., Erez A., Shachar S. B., Izraeli S., Lidzbarsky G., Basel-Salmon L., Biskup S., Maruvka Y. E., Toledano H. & Goldberg Y. (2022), Clinical Genetics. 101, 4, p. 442-447
  • IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells

    Authors: Nachmias B., Khan D. H., Voisin V., Mer A. S., Thomas G. E., Segev N., St-Germain J., Hurren R., Gronda M., Botham A., Wang X., Maclean N., Seneviratne A. K., Duong N., Xu C., Arruda A., Orouji E., Algouneh A., Hakem R., Shlush L., Minden M. D., Raught B., Bader G. D. & Schimmer A. D. (2022), Leukemia. 36, 5, p. 1283-1295
  • Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer

    Authors: Lee W., Maaß M., Quach A., Poscic N., Prangley H., Pallott E., Kim J. L., Pierce J. S., Ogretmen B., Futerman A. H. & Thévenod F. (2022), The journal of Biological chemistry. 298, 2, 101492
  • Ex vivo organotypic cultures for synergistic therapy prioritization identify patient-specific responses to combined MEK and Src inhibition in colorectal cancer

    Authors: Gavert N., Zwang Y., Weiser R., Greenberg O., Halperin S., Jacobi O., Mallel G., Sandler O., Berger A. J., Stossel E., Rotin D., Grinshpun A., Kamer I., Barzs J., Pines G., Saidian D., Bar I., Golan S., Rosenbaum E., Nadu A., Ben-Ami E., Weitzen R., Nechushtan H., Golanz T., Brenner B., Nissan A., Margalitzs O., Hershkovitz D., Lahat G. & Straussman R. (2022), Nature Cancer. 3, 2, p. 219-231
  • Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution

    Authors: Yang D., Jones M. G., Naranjo S., Rideout W. M., Min K. H. (., Ho R., Wu W., Replogle J. M., Page J. L., Quinn J. J., Horns F., Qiu X., Chen M. Z., Freed-Pastor W. A., McGinnis C. S., Patterson D. M., Gartner Z. J., Chow E. D., Bivona T. G., Chan M. M., Yosef N., Jacks T. & Weissman J. S. (2022), Cell. 185, 11, p. 1905-1923.e25
  • Polyclonal antibody-induced downregulation of HER1/EGFR and HER2 surpasses the effect of combinations of specific registered antibodies

    Authors: Bergado-Báez G., Gonzalez Suarez N., García L. C., Pérez-Martínez D., Hernández-Fernández D. R., Fundora-Barrios T., Rodríguez-Álvarez A., Díaz-Ordaz G. D., Lindzen M., Yarden Y. & Sánchez-Ramírez B. (2022), Frontiers in Oncology. 12
  • H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape

    Authors: Furth N., Algranati D., Dassa B., Beresh O., Fedyuk V., Morris N., Kasper L. H., Jones D., Monje M., Baker S. J. & Shema E. (2022), Cell Reports. 39, 7, 110836
  • Compartmentalization of the host microbiome: how tumor microbiota shapes checkpoint immunotherapy outcome and offers therapeutic prospects

    Authors: Boesch M., Horvath L., Baty F., Pircher A., Wolf D., Spahn S., Straussman R., Tilg H. & Brutsche M. H. (2022), Journal for ImmunoTherapy of Cancer. 10, e005401
  • Stochastic transitions as a major source of cancer heterogeneity

    Authors: Tirosh I. (2022),
  • Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions

    Authors: Narunsky-Haziza L., Sepich-Poore G. D., Livyatan I., Asraf O., Martino C., Nejman D., Gavert N., Stajich J. E., Amit G., González A., Wandro S., Perry G., Ariel R., Meltser A., Shaffer J. P., Zhu Q., Balint-Lahat N., Barshack I., Dadiani M., Gal-Yam E. N., Patel S. P., Bashan A., Swafford A. D., Pilpel Y., Knight R. & Straussman R. (2022), Cell. 185, 20, p. 3789-3806
  • A coalition to heal—the impact of the cardiac microenvironment

    Authors: Tzahor E. & Dimmeler S. (2022), Science. 377, 6610, 1059
  • Cancer-associated fibroblasts in the single-cell era

    Authors: Lavie D., Ben-Shmuel A., Erez N. & Scherz-Shouval R. (2022), Nature Cancer. 3, 7, p. 793-807
  • CD74 as a regulator of transcription in normal B cells

    Authors: David K., Friedlander G., Pellegrino B., Radomir L., Lewinsky H., Leng L., Bucala R., Becker-Herman S. & Shachar I. (2022), Cell reports (Cambridge). 41, 5, 111572
  • An exercise-induced metabolic shield in distant organs blocks cancer progression and metastatic dissemination

    Authors: Sheinboim D., Parikh S., Manich P., Markus I., Dahan S., Parikh R., Stubbs E., Cohen G., Zemser-Werner V., Bell R. E., Arciniegas Ruiz S., Percik R., Brenner R., Leibou S., Vaknine H., Arad G., Gerber Y., Keinan Boker L., Shimony T., Goldstein N., Bikovski L., Constantini K., Labes S., Mordechai S., Doron H., Ionescu A., Ziv T., Nizri E., Choshen G., Eldar-Finkelman H., Tabach Y., Helman A., Ben-Eliyahu S., Erez N., Perlson E., Geiger T., Ben-Zvi D., Khaled M., Gepner Y. & Levy C. (2022), Cancer research (Chicago, Ill.).
  • It's all in the combination: decoding the epigenome for cancer research and diagnostics

    Authors: Furth N. & Shema E. (2022), Current Opinion in Genetics and Development. 73, 101899
  • Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas

    Authors: Harpaz N., Mittelman T., Beresh O., Griess O., Furth N., Salame T., Oren R., Fellus-Alyagor L., Harmelin A., Alexandrescu S., Marques J. G., Filbin M. G., Ron G. & Shema E. (2022), Molecular Cell. 82, 14, p. 2696-2713
  • Cardiovascular Disease Among Patients With AML and CHIP-Related Mutations

    Authors: Calvillo-Argüelles O., Schoffel A., Capo-Chichi J., Abdel-Qadir H., Schuh A., Carrillo-Estrada M., Liu S., Gupta V., Schimmer A. D., Yee K., Shlush L. I., Natarajan P. & Thavendiranathan P. (2022), JACC CardioOncology. 4, 1, p. 38-49
  • Immunogenicity and safety of BNT162b2 mRNA vaccine booster in actively treated patients with cancer

    Authors: Ligumsky H., Dor H., Etan T., Golomb I. & Nikolaevski-Berlin A. (2022), The Lancet Oncology. 23, 2, p. 193-195
  • Aptamer-Functionalized Ce4+-Ion-Modified C-Dots: Peroxidase Mimicking Aptananozymes for the Oxidation of Dopamine and Cytotoxic Effects toward Cancer Cells

    Authors: Ouyang Y., Fadeev M., Zhang P., Carmieli R., Sohn Y. S., Karmi O., Qin Y., Chen X., Nechushtai R. & Willner I. (2022), ACS applied materials & interfaces. 14, 50, p. 55365-55375
  • On the development of a neoantigen vaccine for the prevention of Lynch Syndrome

    Authors: Solomon A., Alteber Z., Bassan D., Sharbi-Yunger A., Esbit S., Tzehoval E. & Eisenbach L. (2022), International Journal of Cancer. 151, 1, p. 107-119
  • The brain-immune ecosystem: Implications for immunotherapy in defeating neurodegenerative diseases

    Authors: Schwartz M., Abellanas M. A., Tsitsou-Kampeli A. & Suzzi S. (2022), Neuron (Cambridge, Mass.). 110, 21, p. 3421-3424
  • 5’isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1

    Authors: Li X., Michels B. E., Tosun O. E., Jung J., Kappes J., Ibing S., Nataraj N. B., Sahay S., Schneider M., Wörner A., Becki C., Ishaque N., Feuerbach L., Heßling B., Helm D., Will R., Yarden Y., Müller-Decker K., Wiemann S. & Körner C. (2022), Journal of Experimental and Clinical Cancer Research. 41, 1, 190
  • Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins

    Authors: Mukherjee S., Maddalena M., Lü Y., Martinez S., Nataraj N. B., Noronha A., Sinha S., Teng K., Cohen-Kaplan V., Ziv T., Arandkar S., Hassin O., Chatterjee R., Pirona A., Shreberk-Shaked M., Gershoni A., Aylon Y., Elazar Z., Yarden Y., Schramek D. & Oren M. (2022), Proceedings of the National Academy of Sciences. 119, 17, e211964411
  • BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling

    Authors: Shaashua L., Ben-Shmuel A., Pevsner-Fischer M., Friedman G., Levi-Galibov O., Nandakumar S., Barki D., Nevo R., Brown L. E., Zhang W., Stein Y., Lior C., Kim H. S., Bojmar L., Jarnagin W. R., Lecomte N., Mayer S., Stok R., Bishara H., Hamodi R., Levy-Lahad E., Golan T., Porco J. A., Iacobuzio-Donahue C. A., Schultz N., Tuveson D. A., Lyden D., Kelsen D. & Scherz-Shouval R. (2022), Nature Communications. 13, 1, 6513
  • The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response

    Authors: Cohen M., Giladi A., Barboy O., Hamon P., Li B., Zada M., Gurevich-Shapiro A., Beccaria C. G., David E., Maier B. B., Buckup M., Kamer I., Deczkowska A., Le Berichel J., Bar J., Iannacone M., Tanay A., Merad M. & Amit I. (2022), Nature Cancer. 3, p. 303-317
  • Global DNA Methylation Analysis of Cancer-Associated Fibroblasts Reveals Extensive Epigenetic Rewiring Linked with RUNX1 Upregulation in Breast Cancer Stroma

    Authors: Halperin C., Hey J., Weichenhan D., Stein Y., Mayer S., Lutsik P., Plass C. & Scherz-Shouval R. (2022), Cancer Research. 82, 22, p. 4139-4152
  • SmMIP-tools: a computational toolset for processing and analysis of single-molecule molecular inversion probes-derived data

    Authors: Medeiros J. J. F., Capo-Chichi J., Shlush L. I., Dick J. E., Arruda A., Minden M. D. & Abelson S. (2022), Bioinformatics. 38, 8, p. 2088-2095
  • Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism

    Authors: He C., Maniyar R. R., Avraham Y., Zappasodi R., Rusinova R., Newman W., Heath H., Wolchok J. D., Dahan R., Merghoub T. & Meyerson J. (2022), Science advances. 8, 8, eabm4552
  • Controls for Phylogeny and Robust Analysis in Pareto Task Inference

    Authors: Adler M., Tendler A., Hausser J., Korem Y., Szekely P., Bossel N., Hart Y., Karin O., Mayo A. & Alon U. (2022), Molecular Biology and Evolution. 39, 1, msab297
  • An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes

    Authors: Jaiswal A., Verma A., Dannenfelser R., Melssen M., Tirosh I., Izar B., Kim T., Nirschl C. J., Devi K. S. P., Olson W. C., Slingluff C. L., Engelhard V. H., Garraway L., Regev A., Minkis K., Yoon C. H., Troyanskaya O., Elemento O., Suárez-Fariñas M. & Anandasabapathy N. (2022), Cancer Cell. 40, 5, p. 524-544.e5
  • Anti-SARS-CoV-2 immunoadhesin remains effective against Omicron and other emerging variants of concern

    Authors: Cohen-Dvashi H., Weinstein J., Katz M., Ashkenazy-Eilon M., Mor Y., Shimon A., Achdout H., Tamir H., Israely T., Strobelt R., Shemesh M., Stoler-Barak L., Shulman Z., Paran N., Fleishman S. J. & Diskin R. (2022), iScience. 25, 10, 105193
  • Divergence of mutational signatures in association with breast cancer subtype

    Authors: Perry G., Dadiani M., Kahana-Edwin S., Pavlovski A., Markus B., Hornung G., Balint-Lahat N., Yosepovich A., Hout-Siloni G., Jacob-Hirsch J., Sklair-Levy M., Friedman E., Barshack I., Kaufman B., Gal-Yam E. N. & Paluch-Shimon S. (2022), Molecular Carcinogenesis. 61, 11, p. 1056-1070
  • A Functional Pre-Screening Platform for Identifying Points of Vulnerability in the Cell Death Map of Human Melanoma Tumors

    Authors: Dekel-Bird N. P., Bialik S., Itzhaki O., Meir Salame T., Yaeli-Slonim N., Levin-Salomon V., Dasari S. K., Besser M. & Kimchi A. (2022), Journal of Cancer Science and Clinical Therapeutics. 6, 1, p. 39-60
  • Cytoplasmic forces functionally reorganize nuclear condensates in oocytes

    Authors: Al Jord A., Letort G., Chanet S., Tsai F. C., Antoniewski C., Eichmuller A., Da Silva C., Huynh J. R., Gov N. S., Voituriez R., Terret M. É. & Verlhac M. H. (2022), Nature Communications. 13, 1, 5070
  • Interactive, integrated analysis of single-cell transcriptomic and phylogenetic data with PhyloVision

    Authors: Jones M. G., Rosen Y. & Yosef N. (2022), Cell Reports Methods. 2, 4, 100200
  • The magnitude of LFA-1/ICAM-1 forces fine-tune TCR-triggered T cell activation

    Authors: Ma V. P., Hu Y., Kellner A. V., Brockman J. M., Velusamy A., Blanchard A. T., Evavold B. D., Alon R. & Salaita K. (2022), Science Advances. 8, 8, eabg4485
  • Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients

    Authors: Hassin O., Nataraj N. B., Shreberk-Shaked M., Aylon Y., Yaeger R., Fontemaggi G., Mukherjee S., Maddalena M., Avioz A., Iancu O., Mallel G., Gershoni A., Grosheva I., Feldmesser E., Ben-Dor S., Golani O., Hendel A., Blandino G., Kelsen D., Yarden Y. & Oren M. (2022), Nature Communications. 13, 1, 2800
  • Visual barcodes for clonal-multiplexing of live microscopy-based assays

    Authors: Kaufman T., Nitzan E., Firestein N., Ginzberg M. B., Iyengar S., Patel N., Ben-Hamo R., Porat Z., Hunter J., Hilfinger A., Rotter V., Kafri R. & Straussman R. (2022), Nature Communications. 13, 1, 2725
  • Whole-exome sequencing of HPV positive tonsillar and base of tongue squamous cell carcinomas reveals a global mutational pattern along with relapse-specific somatic variants

    Authors: Ährlund-Richter A., Holzhauser S., Dalianis T., Näsman A. & Mints M. (2022), Cancers. 14, 1, 77
  • Early antitumor activity of oral Langerhans cells is compromised by a carcinogen

    Authors: Saba Y., Aizenbud I., Matanes D., Koren N., Barel O., Zubeidat K., Capucha T., David E., Eli-Berchoer L., Stoitzner P., Wilensky A., Amit I., Czerninski R., Yona S. & Hovav A. (2022), Proceedings of the National Academy of Sciences of the United States of America. 119, 3, e211842411
  • Nine receptors and binding proteins, four drugs, and one woman: Historical and personal perspectives

    Authors: Novick D. (2022), Frontiers in Drug Discovery. 2, 1001487
  • Genetic insight into Birt–Hogg–Dubé syndrome in Indian patients reveals novel mutations at FLCN

    Authors: Ray A., Chattopadhyay E., Singh R., Ghosh S., Bera A., Sarma M., Munot M., Desai U., Rajan S., Prabhudesai P., Prakash A. K., Roy Chowdhury S., Bhowmick N., Dhar R., Udwadia Z. F., Dey A., Mitra S., Joshi J. M., Maitra A. & Roy B. (2022), Orphanet Journal of Rare Diseases. 17, 1, 176
  • Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma

    Authors: Risom T., Glass D. R., Averbukh I., Liu C. C., Baranski A., Kagel A., McCaffrey E. F., Greenwald N. F., Rivero-Gutierrez B., Strand S. H., Varma S., Kong A., Keren L., Srivastava S., Zhu C., Khair Z., Veis D. J., Deschryver K., Vennam S., Maley C., Hwang E. S., Marks J. R., Bendall S. C., Colditz G. A., West R. B. & Angelo M. (2022), Cell. 185, 2, p. 299-310.e18
  • DOP53 In-depth characterisation of the serum antibody epitope repertoire in Inflammatory Bowel Disease by high-throughput phage-displayed immunoprecipitation sequencing

    Authors: Bourgonje A. R., Andreu-Sánchez S., Vogl T., Hu S., Vich Vila A., Leviatan S., Kurilshikov A., Klompus S., Kalka I. N., van Dullemen H. M., Weinberger A., Visschedijk M. C., Festen E. A. M., Faber K. N., Wijmenga C., Dijkstra G., Segal E., Fu J., Zhernakova A. & Weersma R. K. (2022), Journal of Crohn's and Colitis. 16, Supplement_1, p. i100-i102
  • CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia

    Authors: Thavayogarajah T., Sinitski D., El Bounkari O., Torres-Garcia L., Lewinsky H., Harjung A., Chen H., Panse J., Vankann L., Shachar I., Bernhagen J. & Koschmieder S. (2022), Experimental Hematology. 115, p. 30-43
  • AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer

    Authors: Noronha A., Belugali Nataraj N., Sang Lee J., Zhitomirsky B., Oren Y., Oster S., Lindzen M., Mukherjee S., Will R., Ghosh S., Simoni-Nieves A., Verma A., Chatterjee R., Borgoni S., Robinson W., Sinha S., Brandis A., Kerr D. L., Wu W., Sekar A., Giri S., Chung Y., Drago-Garcia D., Danysh B. P., Lauriola M., Fiorentino M., Ardizzoni A., Oren M., Blakely C. M., Ezike J., Wiemann S., Parida L., Bivona T. G., Aqeilan R. I., Brugge J. S., Regev A., Getz G., Ruppin E. & Yarden Y. (2022), Cancer Discovery. 12, 11, p. 2666-2683
  • Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis

    Authors: Zhang Y., Donaher J. L., Das S., Li X., Reinhardt F., Krall J. A., Lambert A. W., Thiru P., Keys H. R., Khan M., Hofree M., Wilson M. M., Yedier-Bayram O., Lack N. A., Onder T. T., Bagci-Onder T., Tyler M., Tirosh I., Regev A., Lees J. A. & Weinberg R. A. (2022), Nature Cell Biology. 24, 4, p. 554-564
  • Blockade of the protease ADAM17 ameliorates experimental pancreatitis

    Authors: Saad M., Weng T., Lundy J., Gearing L., West A., Harpur C., Alanazi M., Hodges C., Croagh D., Kumar B., Sagi I., Rose-John S. & Jenkins B. (2022), Proceedings of the National Academy of Sciences. 119, 42, e221374411
  • Brain metastases: Not all tumors are created equal

    Authors: Kirschenbaum D. & Amit I. (2022), Neuron (Cambridge, Mass.). 110, 7, p. 1097-1099
  • Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues

    Authors: Crawford D. R., Sinha S., Nair N. U., Ryan B. M., Barnholtz-Sloan J. S., Mount S. M., Erez A., Aldape K., Castle P. E., Rajagopal P. S., Day C., Schäffer A. A. & Ruppin E. (2022), Cancers. 14, 23, 5885
  • Drugging p53 in cancer: one protein, many targets

    Authors: Hassin O. & Oren M. (2022), Nature reviews. Drug discovery. p. 1-18
  • Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer

    Authors: Salaroglio I. C., Belisario D. C., Akman M., La Vecchia S., Godel M., Anobile D. P., Ortone G., Digiovanni S., Fontana S., Costamagna C., Rubinstein M., Kopecka J. & Riganti C. (2022), Journal Of Experimental & Clinical Cancer Research. 41, 1, 243
  • Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

    Authors: Ogran A., Havkin-Solomon T., Becker-Herman S., David K., Shachar I. & Dikstein R. (2022), eLife. 11, e77714
  • S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair

    Authors: Amar-Schwartz A., Ben Hur V., Jbara A., Cohen Y., Barnabas G. D., Arbib E., Siegfried Z., Mashahreh B., Hassouna F., Shilo A., Abu-Odeh M., Berger M., Wiener R., Aqeilan R., Geiger T. & Karni R. (2022), eLife. 11
  • Spatial organization and early signaling of the B-cell receptor in CLL

    Authors: Arbel Y. S., Bronstein Y., Dadosh T., Kamdjou T., Tsuriel S., Shapiro M., Katz B. & Herishanu Y. (2022), Frontiers in Immunology. 13, 953660
  • Mouse Modeling Dissecting Macrophage–Breast Cancer Communication Uncovered Roles of PYK2 in Macrophage Recruitment and Breast Tumorigenesis

    Authors: Muller A., Kohler U. A., Trzebanski S., Vinik Y., Mohan Raju H. R., Girault J., Ben-Chetrit N., Maraver A., Jung S. & Lev S. (2022), Advanced Science. 9, 9, 2105696
  • Intratumor heterogeneity and anti-tumor immunity shape one another bidirectionally

    Authors: Wolf Y. & Samuels Y. (2022), Clinical Cancer Research. 28, 14, p. 2994-3001
  • The microbiome and human cancer

    Authors: Sepich-Poore G. D., Zitvogel L., Straussman R., Hasty J., Wargo J. A. & Knight R. (2021), Science. 371, 6536, eabc4552
  • Single Instillation of Hypertonic Saline Immediately Following Transurethral Resection of Bladder Tumor for Recurrence Prevention –A Phase I Study

    Authors: Modai J., Kovalyonok A., Scherz A., Preise D., Avda Y., Shpunt I., Sasson K., Jaber M., Peretz Y., Croock R., Shilo Y., Ikher S., Lindner U. & Leibovici D. (2021), Bladder Cancer. 7, 2, p. 187-192
  • Albumin-EDTA-Vanadium Is a Powerful Anti-Proliferative Agent, Following Entrance into Glioma Cells via Caveolae-Mediated Endocytosis

    Authors: Cooper I., Ravid O., Rand D., Atrakchi D., Shemesh C., Bresler Y., Ben-Nissan G., Sharon M., Fridkin M. & Shechter Y. (2021), Pharmaceutics. 13, 10, 1557
  • Identification of variable stages in murine pancreatic tumors by a multiparametric approach employing hyperpolarized 13C MRSI, 1H diffusivity and 1H T1 MRI

    Authors: Martinho R. P., Bao Q., Markovic S., Preise D., Sasson K., Agemy L., Scherz A. & Frydman L. (2021), NMR in Biomedicine. 34, 2, 4446
  • Improving deuterium metabolic imaging (DMI) signal‐to‐noise ratio by spectroscopic multi‐echo bSSFP: A pancreatic cancer investigation

    Authors: Peters D. C., Markovic S., Bao Q., Preise D., Sasson K., Agemy L., Scherz A. & Frydman L. (2021), Magnetic Resonance in Medicine. 86, 5, p. 2604-2617
  • TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment

    Authors: Maddalena M., Mallel G., Nataraj N. B., Shreberk-Shaked M., Hassin O., Mukherjee S., Arandkar S., Rotkopf R., Kapsack A., Lambiase G., Pellegrino B., Ben-Isaac E., Golani O., Addadi Y., Hajaj E., Eilam R., Straussman R., Yarden Y., Lotem M. & Oren M. (2021), Proceedings of the National Academy of Sciences. 118, 23, e202563111
  • Conformational switches and redox properties of the colon cancer‐associated human lectin ZG16

    Authors: Javitt G., Kinzel A., Reznik N. & Fass D. (2021), The FEBS journal. 288, 22, p. 6465-6475
  • Decoding cancer biology one cell at a time

    Authors: Gonzalez Castro L. N., Tirosh I. & Suvà M. L. (2021), Cancer Discovery. 11, 4, p. 960-970
  • Learned Super Resolution Ultrasound for Improved Breast Lesion Characterization

    Authors: Bar-Shira O., Grubstein A., Rapson Y., Suhami D., Atar E., Peri-Hanania K., Rosen R. & Eldar Y. C. (2021), Medical Image Computing and Computer Assisted Intervention – MICCAI 2021. p. 109-118
  • Melanoma models for the next generation of therapies

    Authors: Patton E. E., Mueller K. L., Adams D. J., Anandasabapathy N., Aplin A. E., Bertolotto C., Bosenberg M., Ceol C. J., Chi P., Herlyn M., Holmen S. L., Karreth F. A., Kaufman C. K., Khan S., Kobold S., Leucci E., Levy C., Lombard D. B., Lund A. W., Marie K. L., Marine J. C., Marais R., McMahon M., Robles-Espinoza C. D., Ronai Z. A., Samuels Y., Soengas M. S., Villanueva J., Weeraratna A. T., White R. M., Yeh I., Zhu J., Zon L. I., Hurlbert M. S. & Merlino G. (2021), Cancer Cell. 39, 5, p. 610-631
  • Spatially organized multicellular immune hubs in human colorectal cancer

    Authors: Pelka K., Hofree M., Chen J. H., Sarkizova S., Pirl J. D., Jorgji V., Bejnood A., Dionne D., Ge W. H., Xu K. H., Chao S. X., Zollinger D. R., Lieb D. J., Reeves J. W., Fuhrman C. A., Hoang M. L., Delorey T., Nguyen L. T., Waldman J., Wakiro I., Klapholz M., Cohen O., Albers J., Smillie C. S., Cuoco M. S., Wu J., Su M., Yeung J., Vijaykumar B., Magnuson A. M., Asinovski N., Moll T., Goder-Reiser M. N., Applebaum A. S., Brais L. K., DelloStritto L. K., Denning S. L., Phillips S. T., Hill E. K., Meehan J. K., Frederick D. T., Sharova T., Kanodia A., Todres E. Z., Jané-Valbuena J., Biton M., Izar B., Lambden C. D., Clancy T. E., Bleday R., Melnitchouk N., Irani J., Kunitake H., Berger D. L., Srivastava A., Hornick J. L., Ogino S., Rotem A., Vigneau S., Johnson B. E., Corcoran R. B., Sharpe A. H., Kuchroo V. K., Ng K., Giannakis M., Nieman L. T., Boland G. M., Aguirre A. J., Anderson A. C., Rozenblatt-Rosen O., Regev A. & Hacohen N. (2021), Cell. 184, 18, p. 4734-4752.e20
  • Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans

    Authors: Gordin M., Philip H., Zilberberg A., Gidoni M., Margalit R., Clouser C., Adams K., Vigneault F., Cohen I. R., Yaari G. & Efroni S. (2021), PLoS Computational Biology. 17, 1, 1008486
  • Identification of bacteria-derived HLA-bound peptides in melanoma

    Authors: Kalaora S., Nagler A., Nejman D., Alon M., Barbolin C., Barnea E., Ketelaars S. L. C., Cheng K., Vervier K., Shental N., Bussi Y., Rotkopf R., Levy R., Benedek G., Trabish S., Dadosh T., Levin-Zaidman S., Geller L. T., Wang K., Greenberg P., Yagel G., Peri A., Fuks G., Bhardwaj N., Reuben A., Hermida L., Johnson S. B., Galloway-Peña J. R., Shropshire W. C., Bernatchez C., Haymaker C., Arora R., Roitman L., Eilam R., Weinberger A., Lotan-Pompan M., Lotem M., Levin Y., Lawley T. D., Adams D. J., Levesque M. P., Besser M. J., Schachter J., Golani O., Segal E., Ruppin E., Kvistborg P., Peterson S. N., Wargo J. A., Straussman R. & Samuels Y. (2021), Nature (London). 592, 7852, p. 138-143
  • CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma

    Authors: Lewinsky H., Gunes E. G., David K., Radomir L., Kramer M. P., Pellegrino B., Perpinial M., Chen J., He T. F., Mansour A. G., Teng K. Y., Bhattacharya S., Caserta E., Troadec E., Lee P., Feng M., Keats J., Krishnan A., Rosenzweig M., Yu J., Caligiuri M. A., Cohen Y., Shevetz O., Becker-Herman S., Pichiorri F., Rosen S. & Shachar I. (2021), JCI insight. 6, 4, 141683
  • Chromothripsis drives the evolution of gene amplification in cancer

    Authors: Shoshani O., Brunner S. F., Yaeger R., Ly P., Nechemia-Arbely Y., Kim D. H., Fang R., Castillon G. A., Yu M., Li J. S. Z., Sun Y., Ellisman M. H., Ren B., Campbell P. J. & Cleveland D. W. (2021), Nature (London). 591, 7848, p. 137-141
  • Persistent Inflammatory Stimulation Drives the Conversion of MSCs to Inflammatory CAFs That Promote Pro-Metastatic Characteristics in Breast Cancer Cells

    Authors: Rubinstein-Achiasaf L., Morein D., Ben-Yaakov H., Liubomirski Y., Meshel T., Elbaz E., Dorot O., Pichinuk E., Gershovits M., Weil M. & Ben-Baruch A. (2021), Cancers. 13, 6, 1472
  • Proteomic Profiling of Tissue Exosomes Indicates Continuous Release of Malignant Exosomes in Urinary Bladder Cancer Patients, Even with Pathologically Undetectable Tumour

    Authors: Eldh M., Mints M., Hiltbrunner S., Ladjevardi S., Alamdari F., Johansson M., Jakubczyk T., Veerman R. E., Winqvist O., Sherif A. & Gabrielsson S. (2021), Cancers. 13, 13, 3242
  • P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression

    Authors: Yeini E., Ofek P., Pozzi S., Albeck N., Ben-Shushan D., Tiram G., Golan S., Kleiner R., Sheinin R., Israeli Dangoor S., Reich-Zeliger S., Grossman R., Ram Z., Brem H., Hyde T. M., Magod P., Friedmann-Morvinski D., Madi A. & Satchi-Fainaro R. (2021), Nature Communications. 12, 1912
  • The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development

    Authors: Sun X., Malandraki-Miller S., Kennedy T., Bassat E., Klaourakis K., Zhao J., Gamen E., Vieira J. M., Tzahor E. & Riley P. R. (2021), Development (Cambridge). 148, 9
  • CYP46A1-APOE axis at the choroid plexus is compromised in Alzheimer's disease but is amenable to rescue

    Authors: Tsitsou A., Suzzi S., Kenigsbuch M., Singer O., Strobelt R., Cahalon L., Arad M., Colaiuta S. P., Medina S., Kviatcovsky D. & Schwartz M. (2021),
  • Alternative splicing of the inhibitory immune checkpoint receptor SLAMF6 generates a dominant positive form, boosting T-cell effector functions

    Authors: Hajaj E., Zisman E., Tzaban S., Merims S., Cohen J., Klein S., Frankenburg S., Sade-Feldman M., Tabach Y., Yizhak K., Navon A., Stepensky P., Hacohen N., Peretz T., Veillette A., Karni R., Eisenberg G. & Lotem M. (2021), Cancer Immunology Research. 9, 6, p. 637-650
  • Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles

    Authors: Tawil N., Bassawon R., Meehan B., Nehme A., Montermini L., Gayden T., De Jay N., Spinelli C., Chennakrishnaiah S., Choi D., Adnani L., Zeinieh M., Jabado N., Kleinman C. L., Witcher M., Riazalhosseini Y., Key N. S., Schiff D., Grover S. P., Mackman N., Couturier C. P., Petrecca K., Suvà M. L., Patel A., Tirosh I., Najafabadi H. & Rak J. (2021), Blood advances. 5, 6, p. 1682-1694
  • The context-specific roles of urea cycle enzymes in tumorigenesis

    Authors: Hajaj E., Sciacovelli M., Frezza C. & Erez A. (2021), Molecular Cell. 81, 18, p. 3749-3759
  • Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

    Authors: Hara T., Chanoch-Myers R., Mathewson N. D., Myskiw C., Atta L., Bussema L., Eichhorn S. W., Greenwald A. C., Kinker G. S., Rodman C., Gonzalez Castro L. N., Wakimoto H., Rozenblatt-Rosen O., Zhuang X., Fan J., Hunter T., Verma I. M., Wucherpfennig K. W., Regev A., Suvà M. L. & Tirosh I. (2021), Cancer Cell. 39, 6, p. 779-792.e11
  • Diffusion Is Directional: Innovative Diffusion Tensor Imaging to Improve Prostate Cancer Detection

    Authors: Shenhar C., Degani H., Ber Y., Baniel J., Tamir S., Benjaminov O., Rosen P., Furman-Haran E. & Margel D. (2021), Diagnostics. 11, 3, 563
  • Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies

    Authors: Borenstein-Katz A., Warszawski S., Amon R., Eilon M., Cohen-Dvashi H., Leviatan Ben-Arye S., Tasnima N., Yu H., Chen X., Padler-Karavani V., Fleishman S. J. & Diskin R. (2021), Journal of Molecular Biology. 433, 15, 167099
  • The prospects of tumor chemosensitivity testing at the single-cell level

    Authors: Yang C., Yang C., Yarden Y., To K. K. & Fu L. (2021), Drug Resistance Updates. 54, 100741
  • Multiplexed Imaging Analysis of the Tumor-Immune Microenvironment Reveals Predictors of Outcome in Triple-Negative Breast Cancer

    Authors: Patwa A., Yamashita R., Long J., Angelo M., Yankielowicz-Keren L. & Rubin D. L. (2021), Communications Biology. 4, 852
  • TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer

    Authors: Swain U., Friedlander G., Sehrawat U., Sarusi-Portuguez A., Rotkopf R., Ebert C., Paz-Elizur T., Dikstein R., Carell T., Geacintov N. E. & Livneh Z. (2021), International Journal of Molecular Sciences. 22, 13, 6957
  • Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models

    Authors: Marrocco I., Romaniello D., Vaknin I., Drago‐Garcia D., Oren R., Uribe M. L., Belugali Nataraj N., Ghosh S., Eilam R., Salame T., Lindzen M. & Yarden Y. (2021), EMBO Molecular Medicine. 13, 4, 13144
  • Anti-tumour immunity induces aberrant peptide presentation in melanoma

    Authors: Bartok O., Pataskar A., Nagel R., Laos M., Goldfarb E., Hayoun D., Levy R., Körner P., Kreuger I. Z. M., Champagne J., Zaal E. A., Bleijerveld O. B., Huang X., Kenski J., Wargo J., Brandis A., Levin Y., Mizrahi O., Alon M., Lebon S., Yang W., Nielsen M. M., Stern-Ginossar N., Altelaar M., Berkers C. R., Geiger T., Peeper D. S., Olweus J., Samuels Y. & Agami R. (2021), Nature. 590, 7845, p. 332-337
  • Efficient acquisition of tens of thousands of short tandem repeats in single-cell whole-genome-amplified DNA

    Authors: Tao L., Marx Z., Raz O. & Shapiro E. (2021), STAR Protocols. 2, 4, 100828
  • Coordinated regulation of WNT/β-catenin, c-Met, and integrin signalling pathways by miR-193b controls triple negative breast cancer metastatic traits

    Authors: Giacomelli C., Jung J., Wachter A., Ibing S., Will R., Uhlmann S., Mannsperger H., Sahin Ö., Yarden Y., Beißbarth T., Korf U., Körner C. & Wiemann S. (2021), BMC Cancer. 21, 1296
  • Clump sequencing exposes the spatial expression programs of intestinal secretory cells

    Authors: Manco R., Averbukh I., Porat Z., Bahar Halpern K., Amit I. & Itzkovitz S. (2021), Nature Communications. 12, p. -, 3074
  • Proteomic patterns associated with response to breast cancer neoadjuvant treatment

    Authors: Shenoy A., Belugali Nataraj N., Perry G., Loayza Puch F., Nagel R., Marin I., Balint N., Bossel N., Pavlovsky A., Barshack I., Kaufman B., Agami R., Yarden Y., Dadiani M. & Geiger T. (2021), Molecular Systems Biology. 16, 9, e9443
  • Reduced Lamin A/C Does Not Facilitate Cancer Cell Transendothelial Migration but Compromises Lung Metastasis

    Authors: Roncato F., Regev O., Feigelson S. W., Yadav S. K., Kaczmarczyk L., Levi N., Drago-Garcia D., Ovadia S., Kizner M., Addadi Y., Sabino J. C., Ovadya Y., de Almeida S. F., Feldmesser E., Gerlitz G. & Alon R. (2021), Cancers. 13, 10, 2383
  • Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response

    Authors: Ariav Y., Ch’ng J. H., Christofk H. R., Ron-Harel N. & Erez A. (2021), Science advances. 7, 21, eabg6165
  • Immunotherapy for Triple-Negative Breast Cancer

    Authors: Cao Y., Chen C., Tao Y., Lin W. & Wang P. (2021), Pharmaceutics. 13, 12, 2003
  • Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis

    Authors: Bolik J., Krause F., Stevanovic M., Gandraß M., Thomsen I., Schacht S., Rieser E., Müller M., Schumacher N., Fritsch J., Wichert R., Galun E., Bergmann J., Röder C., Schafmayer C., Egberts J., Becker-Pauly C., Saftig P., Lucius R., Schneider-Brachert W., Barikbin R., Adam D., Voss M., Hitzl W., Krüger A., Strilic B., Sagi I., Walczak H., Rose-John S. & Schmidt-Arras D. (2021), Journal of Experimental Medicine. 219, 1, e20201039
  • Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity

    Authors: Shani O., Raz Y., Monteran L., Scharff Y., Levi-Galibov O., Megides O., Shacham H., Cohen N., Silverbush D., Avivi C., Sharan R., Madi A., Scherz-Shouval R., Barshack I., Tsarfaty I. & Erez N. (2021), eLife. 10, e60745
  • The key roles of cancer stem cell-derived extracellular vesicles

    Authors: Su C., Zhang J., Yarden Y. & Fu L. (2021), Signal Transduction and Targeted Therapy. 6, 1, 109
  • EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired Resistance

    Authors: Uribe M. L., Marrocco I. & Yarden Y. (2021), Cancers. 13, 11, 2748
  • Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill

    Authors: Mohan V., Gaffney J. P., Solomonov I., Levin M., Klepfish M., Akbareian S., Grünwald B., Dym O., Eisenstein M., Yu K. H., Kelsen D. P., Krüger A., Edwards D. R. & Sagi I. (2021), Cancers. 13, 7, 1679
  • Cellular senescence in ageing: from mechanisms to therapeutic opportunities

    Authors: Di Micco R., Krizhanovsky V., Baker D. & di Fagagna F. d. (2021), Nature Reviews Molecular Cell Biology. 22, 2, p. 75-95
  • Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

    Authors: Dubiella C., Pinch B. J., Koikawa K., Zaidman D., Poon E., Manz T. D., Nabet B., He S., Resnick E., Rogel A., Langer E. M., Daniel C. J., Seo H., Chen Y., Adelmant G., Sharifzadeh S., Ficarro S. B., Martins da Costa B., Jamin Y., Zimmerman M. W., Lian X., Kibe S., Kozono S., Doctor Z. M., Browne C. M., Yang A., Stoler-Barak L., Shah R. B., Vangos N. E., Geffken E. A., Oren R., Koide E., Sidi S., Shulman Z., Wang C., Marto J. A., Dhe-Paganon S., Look T., Zhou X. Z., Lu K. P., Sears R. C., Chesler L., Gray N. S. & London N. (2021), Nature Chemical Biology. 17, 9, p. 954-963
  • Clinical Proteomics of Metastatic Melanoma Reveals Profiles of Organ Specificity and Treatment Resistance

    Authors: Beck L., Harel M., Yu S., Markovits E., Boursi B., Markel G. & Geiger T. (2021), Clinical Cancer Research. 27, 7, p. 2074-2086
  • Biological and therapeutic implications of a unique subtype of NPM1 mutated AML

    Authors: Mer A. S., Heath E. M., Madani Tonekaboni S. A., Dogan-Artun N., Nair S. K., Murison A., Garcia-Prat L., Shlush L., Hurren R., Voisin V., Bader G. D., Nislow C., Rantalainen M., Lehmann S., Gower M., Guidos C. J., Lupien M., Dick J. E., Minden M. D., Schimmer A. D. & Haibe-Kains B. (2021), Nature Communications. 12, 1, 1054
  • Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood

    Authors: Skead K., Houle A. A., Abelson S., Agbessi M., Bruat V., Lin B., Soave D., Shlush L., Wright S., Dick J., Morris Q. & Awadalla P. (2021), Nature Communications. 12, 4921
  • Roles for growth factors and mutations in metastatic dissemination

    Authors: Nataraj N. B., Marrocco I. & Yarden Y. (2021), Biochemical Society Transactions. 49, 3, p. 1409-1423, BST2021004
  • A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma

    Authors: Choi J. E., Sebastian C., Ferrer C. M., Lewis C. A., Sade-Feldman M., LaSalle T., Gonye A., Lopez B. G., Abdelmoula W. M., Regan M. S., Cetinbas M., Pascual G., Wojtkiewicz G. R., Silveira G. G., Boon R., Ross K. N., Tirosh I., Saladi S. V., Ellisen L. W., Sadreyev R. I., Benitah S. A., Agar N. Y., Hacohen N. & Mostoslavsky R. (2021), Nature metabolism. 3, 2, p. 182-195
  • Single cell biology—a Keystone Symposia report

    Authors: Cable J., Elowitz M. B., Domingos A. I., Habib N., Itzkovitz S., Hamidzada H., Balzer M. S., Yanai I., Liberali P., Whited J., Streets A., Cai L., Stergachis A. B., Hong C. K. Y., Keren L., Guilliams M., Alon U., Shalek A. K., Hamel R., Pfau S. J., Raj A., Quake S. R., Zhang N. R., Fan J., Trapnell C., Wang B., Greenwald N. F., Vento-Tormo R., Santos S. D., Spencer S. L., Garcia H. G., Arekatla G., Gaiti F., Arbel-Goren R., Rulands S., Junker J. P., Klein A. M., Morris S. A., Murray J. I., Galloway K. E., Ratz M. & Romeike M. (2021), Annals of the New York Academy of Sciences. 1506, 1, p. 74-97
  • Using a Recently Approved Tumor Mutational Burden Biomarker to Stratify Patients for Immunotherapy May Introduce a Sex Bias

    Authors: Sinha N., Sinha S., Cheng K., Madan S., Erez A., Ryan B. M., Schäffer A. A., Aldape K. & Ruppin E. (2021),
  • Metabolic decisions in development and disease—a Keystone Symposia report

    Authors: Cable J., Pourquié O., Wellen K. E., Finley L. W., Aulehla A., Gould A. P., Teleman A., Tu W. B., Garrett W. S., Miguel-Aliaga I., Perrimon N., Hooper L. V., Walhout A. J., Wei W., Alexandrov T., Erez A., Ralser M., Rabinowitz J. D., Hemalatha A., Gutiérrez-Pérez P., Chandel N. S., Rutter J., Locasale J. W., Landoni J. C. & Christofk H. (2021), Annals of the New York Academy of Sciences. 1506, 1, p. 55-73
  • The evolution of leukaemia from pre‐leukaemic and leukaemic stem cells

    Authors: Shlush L. I. & Feldman T. (2021), Journal of Internal Medicine.
  • Tumour inflammation signature and expression of S100A12 and HLA class I improve survival in HPV-negative hypopharyngeal cancer

    Authors: Mints M., Landin D., Näsman A., Mirzaie L., Ursu R. G., Zupancic M., Marklund L., Dalianis T., Munck-Wikland E. & Ramqvist T. (2021), Scientific Reports. 11, 1782
  • Avidity optimization of a MAGE-A1-specific TCR with somatic hypermutation

    Authors: Bassan D., Gozlan Y. M., Sharbi-Yunger A., Tzehoval E., Greenstein E., Bitan L., Friedman N. & Eisenbach L. (2021), European Journal of Immunology. 51, 6, p. 1505-1518
  • MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression

    Authors: Kinker G. S., Ostrowski L. H., Ribeiro P. A., Chanoch R., Muxel S. M., Tirosh I., Spadoni G., Rivara S., Martins V. R., Santos T. G., Markus R. P. & Fernandes P. A. (2021), Journal of Molecular Medicine. 2, p. 289-301
  • Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis

    Authors: Beyaz S., Chung C., Mou H., Bauer-Rowe K. E., Xifaras M. E., Ergin I., Dohnalova L., Biton M., Shekhar K., Eskiocak O., Papciak K., Ozler K., Almeqdadi M., Yueh B., Fein M., Annamalai D., Valle-Encinas E., Erdemir A., Dogum K., Shah V., Alici-Garipcan A., Meyer H. V., Özata D. M., Elinav E., Kucukural A., Kumar P., McAleer J. P., Fox J. G., Thaiss C. A., Regev A., Roper J., Orkin S. H. & Yilmaz Ö. H. (2021), Cell Stem Cell. 28, 11, p. 1922-1935.e5
  • NASH limits anti-tumour surveillance in immunotherapy-treated HCC

    Authors: Pfister D., Núñez N. G., Pinyol R., Govaere O., Pinter M., Szydlowska M., Gupta R., Qiu M., Deczkowska A., Weiner A., Müller F., Sinha A., Friebel E., Engleitner T., Lenggenhager D., Moncsek A., Heide D., Stirm K., Kosla J., Kotsiliti E., Leone V., Dudek M., Yousuf S., Inverso D., Singh I., Teijeiro A., Castet F., Montironi C., Haber P. K., Tiniakos D., Bedossa P., Cockell S., Younes R., Vacca M., Marra F., Schattenberg J. M., Allison M., Bugianesi E., Ratziu V., Pressiani T., D’Alessio A., Personeni N., Rimassa L., Daly A. K., Scheiner B., Pomej K., Kirstein M. M., Vogel A., Peck-Radosavljevic M., Hucke F., Finkelmeier F., Waidmann O., Trojan J., Schulze K., Wege H., Koch S., Weinmann A., Bueter M., Rössler F., Siebenhüner A., De Dosso S., Mallm J. P., Umansky V., Jugold M., Luedde T., Schietinger A., Schirmacher P., Emu B., Augustin H. G., Billeter A., Müller-Stich B., Kikuchi H., Duda D. G., Kütting F., Waldschmidt D. T., Ebert M. P., Rahbari N., Mei H. E., Schulz A. R., Ringelhan M., Malek N., Spahn S., Bitzer M., Ruiz de Galarreta M., Lujambio A., Dufour J. F., Marron T. U., Kaseb A., Kudo M., Huang Y. H., Djouder N., Wolter K., Zender L., Marche P. N., Decaens T., Pinato D. J., Rad R., Mertens J. C., Weber A., Unger K., Meissner F., Roth S., Jilkova Z. M., Claassen M., Anstee Q. M., Amit I., Knolle P., Becher B., Llovet J. M. & Heikenwalder M. (2021), Nature (London). 592, 7854, p. 450-456
  • Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma

    Authors: Peri A., Greenstein E., Alon M., Pai J. A., Dingjan T., Reich-Zeliger S., Barnea E., Barbolin C., Levy R., Arnedo-Pac C., Kalaora S., Dassa B., Feldmesser E., Shang P., Greenberg P., Levin Y., Benedek G., Levesque M. P., Adams D. J., Lotem M., Wilmott J. S., Scolyer R. A., Jönsson G. B., Admon A., Rosenberg S. A., Cohen C. J., Niv M. Y., Lopez-Bigas N., Satpathy A. T., Friedman N. & Samuels Y. (2021), The Journal of Clinical Investigation. 131, 20, e129466
  • LFA-1 in T cell priming, differentiation, and effector functions

    Authors: Gérard A., Cope A. P., Kemper C., Alon R. & Köchl R. (2021), Trends in Immunology. 42, 8, p. 706-722
  • Cancer-associated fibroblasts promote aggressive gastric cancer phenotypes via heat shock factor 1-mediated secretion of extracellular vesicles

    Authors: Grunberg N., Pevsner-Fischer M., Goshen-Lago T., Diment J., Stein Y., Lavon H., Mayer S., Levi-Galibov O., Friedman G., Ofir-Birin Y., Syu L., Migliore C., Shimoni E., Stemmer S. M., Brenner B., Dlugosz A. A., Lyden D., Regev-Rudzki N., Ben-Aharon I. & Scherz-Shouval R. (2021), Cancer Research. 81, 7, p. 1639-1653
  • ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation

    Authors: Brandao R., Kwa M. Q., Yarden Y. & Brakebusch C. (2021), FEBS Open Bio. 11, 6, p. 1579-1592
  • Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells

    Authors: Shorer Arbel Y., Katz B., Gabizon R., Shraga A., Bronstein Y., Kamdjou T., Globerson Levin A., Perry C., Avivi I., London N. & Herishanu Y. (2021), Frontiers in Oncology. 11, 646971
  • The evolutionarily conserved long non-coding RNA LINC00261 drives neuroendocrine prostate cancer proliferation and metastasis via distinct nuclear and cytoplasmic mechanisms

    Authors: Mather R. L., Parolia A., Carson S. E., Venalainen E., Roig-Carles D., Jaber M., Chu S., Alborelli I., Wu R., Lin D., Nabavi N., Jachetti E., Colombo M. P., Xue H., Pucci P., Ci X., Hawkes C., Li Y., Pandha H., Ulitsky I., Marconett C., Quagliata L., Jiang W., Romero I., Wang Y. & Crea F. (2021), Molecular Oncology. 15, 7, p. 1921-1941
  • Astrocytes Downregulate Inflammation in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome: Applicability to COVID-19

    Authors: Izrael M., Molakandov K., Revel A., Slutsky S. G., Sonnenfeld T., Weiss J. M. & Revel M. (2021), Frontiers in Medicine. 8, 740071
  • Albumin-Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells

    Authors: Cooper I., Schnaider-Beeri M., Fridkin M. & Shechter Y. (2021), Pharmaceutics. 14, 1, 71
  • Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis

    Authors: Tyler M. & Tirosh I. (2021), Nature Communications. 12, 1, 2592
  • Treatment results from a phase I study of WST11 phototherapy (VTP) for upper tract urothelial carcinoma

    Authors: Nogueira L., Tracey A., Alvim R. G., Reisz P., Sjoberg D. D., Demac Q., Benfante N., Nagar K., Thomas J., Cheng J., Kim K., Solit D. B., Scherz A. J. & Coleman J. (2021), Journal of Clinical Oncology. 39, 6_suppl, p. 460-460
  • The Collagen-Modifying Enzyme PLOD2 Is Induced and Required during L1-Mediated Colon Cancer Progression

    Authors: Cheriyamundath S., Kumar A., Gavert N., Brabletz T. & Ben-Ze’ev A. (2021), International Journal of Molecular Sciences. 22, 7, 3552
  • Accelerating AXL targeting for TNBC therapy

  • Putative Blood Somatic Mutations in Post-Traumatic Stress Disorder-Symptomatic Soldiers: High Impact of Cytoskeletal and Inflammatory Proteins

    Authors: Sragovich S., Gershovits M., Lam J. C., Li V. O. & Gozes I. (2021), Journal of Alzheimer's Disease. 79, 4, p. 1723-1734
  • Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

    Authors: Koikawa K., Kibe S., Suizu F., Sekino N., Kim N., Manz T. D., Pinch B. J., Akshinthala D., Verma A., Gaglia G., Nezu Y., Ke S., Qiu C., Ohuchida K., Oda Y., Lee T. H., Wegiel B., Clohessy J. G., London N., Santagata S., Wulf G. M., Hidalgo M., Muthuswamy S. K., Nakamura M., Gray N. S., Zhou X. Z. & Lu K. P. (2021), Cell. 184, 18, p. 4753-4771.e27
  • IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy

    Authors: Jacob Berger A., Gigi E., Kupershmidt L., Meir Z., Gavert N., Zwang Y., Prior A., Gilad S., Harush U., Haviv I., Stemmer S. M., Blum G., Merquiol E., Mardamshina M., Kaminski Strauss S., Friedlander G., Bar J., Kamer I., Reizel Y., Geiger T., Pilpel Y., Levin Y., Tanay A., Barzel B., Reuveni H. & Straussman R. (2021), Nature Cancer. 2, 10, p. 1055-1070
  • Neoadjuvant vascular-targeted photodynamic therapy improves survival and reduces recurrence and progression in a mouse model of urothelial cancer

    Authors: Rosenzweig B., Corradi R. B., Budhu S., Alvim R., Recabal P., La Rosa S., Somma A., Monette S., Scherz A., Kim K. & Coleman J. A. (2021), Scientific Reports. 11, 1, 4842
  • Transient genomic instability drives tumorigenesis through accelerated clonal evolution

    Authors: Shoshani O., Bakker B., de Haan L., Tijhuis A., Wang Y., Kim D. H., Maldonado M., Demarest M., Artates J., Zhengyu O., Mark A., Wardenaar R., Sasik R., Spierings D., Vitre B., Fisch K., Foijer F. & Cleveland D. W. (2021), GENES & DEVELOPMENT. 35, 15-16, p. 1093-1108
  • Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining

    Authors: Feldman T., Bercovich A., Moskovitz Y., Chapal-Ilani N., Mitchell A., Medeiros J. J. F., Biezuner T., Kaushansky N., Minden M. D., Gupta V., Milyavsky M., Livneh Z., Tanay A. & Shlush L. I. (2021), Nature Communications. 12, 1, 2455
  • Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review

    Authors: Kenner B., Chari S. T., Kelsen D., Klimstra D. S., Pandol S. J., Rosenthal M., Rustgi A. K., Taylor J. A., Yala A., Abul-Husn N., Andersen D. K., Bernstein D., Brunak S., Canto M. I., Eldar Y. C., Fishman E. K., Fleshman J., Go V. L. W., Holt J. M., Field B., Goldberg A., Hoos W., Iacobuzio-Donahue C., Li D., Lidgard G., Maitra A., Matrisian L. M., Poblete S., Rothschild L., Sander C., Schwartz L. H., Shalit U., Srivastava S. & Wolpin B. (2021), Pancreas. 50, 3, p. 251-279
  • Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies

    Authors: Cohen M., Giladi A., Raposo C., Zada M., Li B., Ruckh J., Deczkowska A., Mohar B., Shechter R., Lichtenstein R. G., Amit I. & Schwartz M. (2021), Life Science Alliance. 4, 1, 202000907
  • Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation

    Authors: Canu V., Donzelli S., Sacconi A., Lo Sardo F., Pulito C., Bossel N., Di Benedetto A., Muti P., Botti C., Domany E., Bicciato S., Strano S., Yarden Y. & Blandino G. (2021), Cell Death and Differentiation. 28, 5, p. 1493-1511
  • Proteogenomics of glioblastoma associates molecular patterns with survival

    Authors: Yanovich-Arad G., Ofek P., Yeini E., Mardamshina M., Danilevsky A., Shomron N., Grossman R., Satchi-Fainaro R. & Geiger T. (2021), Cell reports (Cambridge). 34, 9, 108787
  • DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

    Authors: Batra R. N., Lifshitz A., Vidakovic A. T., Chin S., Sati-Batra A., Sammut S., Provenzano E., Ali H. R., Dariush A., Bruna A., Murphy L., Purushotham A., Ellis I., Green A., Garrett-Bakelman F. E., Mason C., Melnick A., Aparicio S. A. J. R., Rueda O. M., Caldas C. & Tanay A. (2021), Nature Communications. 12, 1, 5406
  • Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones

    Authors: Rayo J., Gregor R., Jacob N. T., Dandela R., Dubinsky L., Yashkin A., Aranovich A., Thangaraj M., Ernst O., Barash E., Malitsky S., Florea B. I., Krom B. P., Wiemer E. A. C., Kickhoefer V. A., Rome L. H., Mathison J. C., Kaufmann G. F., Overkleeft H. S., Cravatt B. F., Zor T., Janda K. D., Ulevitch R. J., Kravchenko V. V. & Meijler M. M. (2021), Proceedings of the National Academy of Sciences - PNAS. 118, 12, e201252911
  • Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anti-cancer activities in lung adenocarcinoma

    Authors: Singh A., Erijman A., Noronha A., Kumar H., Peleg Y., Yarden Y. & Shifman J. M. (2021), Journal of Biological Chemistry. 297, 6, 101353
  • Microbiome and cancer

    Authors: Cullin N., Azevedo Antunes C., Straussman R., Stein-Thoeringer C. K. & Elinav E. (2021), Cancer Cell. 39, 10, p. 1317-1341
  • Tumor heterogeneity

    Authors: Pe'er D., Ogawa S., Elhanani O., Keren L., Oliver T. G. & Wedge D. (2021), Cancer Cell. 39, 8, p. 1015-1017
  • Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ)

    Authors: Degtjarik O., Golovenko D., Diskin-Posner Y., Abrahmsén L., Rozenberg H. & Shakked Z. (2021), Nature Communications. 12, 7057
  • MEK inhibition reverses aberrant signaling in melanoma cells through reorganization of NRas and BRAF in self nano-clusters

    Authors: Yakovian O., Sajman J., Arafeh R., Neve-Oz Y., Alon M., Samuels Y. & Sherman E. (2021), Cancer research (Chicago, Ill.). 81, 5, p. 1279-1292
  • Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts

    Authors: Quinn J. J., Jones M. G., Okimoto R. A., Nanjo S., Chan M. M., Yosef N., Bivona T. G. & Weissman J. S. (2021), Science. 371, 6532, abc1944
  • Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells

    Authors: Roncato F., Regev O., Yadav S. K. & Alon R. (2021), Cell Adhesion & Migration. 15, 1, p. 166-179
  • P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas

    Authors: Rousso-Noori L., Mastandrea I., Talmor S., Waks T., Globerson Levin A., Haugas M., Teesalu T., Alvarez-Vallina L., Eshhar Z. & Friedmann-Morvinski D. (2021), Nature Communications. 12, 1, 3615
  • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

    Authors: Mathewson N. D., Ashenberg O., Tirosh I., Gritsch S., Perez E. M., Marx S., Jerby-Arnon L., Chanoch-Myers R., Hara T., Richman A. R., Ito Y., Pyrdol J., Friedrich M., Schumann K., Poitras M. J., Gokhale P. C., Gonzalez Castro L. N., Shore M. E., Hebert C. M., Shaw B., Cahill H. L., Drummond M., Zhang W., Olawoyin O., Wakimoto H., Rozenblatt-Rosen O., Brastianos P. K., Liu X. S., Jones P. S., Cahill D. P., Frosch M. P., Louis D. N., Freeman G. J., Ligon K. L., Marson A., Chiocca E. A., Reardon D. A., Regev A., Suvà M. L. & Wucherpfennig K. W. (2021), Cell. 184, 5, p. 1281-1298
  • SCIRT lncRNA Restrains Tumorigenesis by Opposing Transcriptional Programs of Tumor-Initiating Cells

    Authors: Zagorac S., de Giorgio A., Dabrowska A., Kalisz M., Casas-Vila N., Cathcart P., Yiu A., Ottaviani S., Degani N., Lombardo Y., Tweedie A., Nissan T., Vance K. W., Ulitsky I., Stebbing J. & Castellano L. (2021), Cancer Research. 81, 3, p. 580-593
  • Tumor cells in light-chain amyloidosis and myeloma show different transcriptional rewiring of normal plasma cell development

    Authors: Alameda D., Goicoechea I., Vicari M., Arriazu E., Nevone A., Rodríguez S., Lasa M., Puig N., Cedena M., Alignani D., Garate S., Lara-Astiaso D., Vilas-Zornoza A., Sarvide S., Ocio E. M., Lecumberri R., Garcia de Coca A., Labrador J., Gonzalez M., Palomera L., Gironella M., Cabañas V., Casanova M., Oriol A., Krsnik I., Pérez-Montaña A., de la Rubia J., de la Puerta J., de Arriba F., Fazio V. M., Martinez-Lopez J., Lahuerta J., Mateos M., Odero M. D., Prosper F., Weiner A., Amit I., Nuvolone M., San-Miguel J. F. F. & Paiva B. (2021), Blood. 138, 17, p. 1583-1589
  • β2-Integrin Adhesion Regulates Dendritic Cell Epigenetic and Transcriptional Landscapes to Restrict Dendritic Cell Maturation and Tumor Rejection

    Authors: Guenther C., Faisal I., Fusciello M., Sokolova M., Harjunpää H., Ilander M., Tallberg R., Vartiainen M. K., Alon R., Gonzalez-Granado J., Cerullo V. & Fagerholm S. C. (2021), Cancer Immunology Research. 9, 11, p. 1354-1369
  • PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR

    Authors: Ghosh S., Nataraj N. B., Noronha A., Patkar S., Sekar A., Mukherjee S., Winograd-Katz S., Kramarski L., Verma A., Lindzen M., Garcia D. D., Green J., Eisenberg G., Gil-Henn H., Basu A., Lender Y., Weiss S., Oren M., Lotem M., Geiger B., Ruppin E. & Yarden Y. (2021), Cell Reports. 35, 8, 109181
  • Intratumoral heterogeneity in cancer progression and response to immunotherapy

    Authors: Vitale I., Shema E., Loi S. & Galluzzi L. (2021), Nature Medicine. 27, 2, p. 212-224
  • Retrospective cell lineage reconstruction in humans by using short tandem repeats

    Authors: Tao L., Raz O., Marx Z., Ghosh M. S., Huber S., Greindl-Junghans J., Biezuner T., Amir S., Milo L., Adar R., Levy R., Onn A., Chapal-Ilani N., Berman V., Ben Arie A., Rom G., Oron B., Halaban R., Czyz Z. T., Werner-Klein M., Klein C. A. & Shapiro E. (2021), Cell Reports Methods. 1, 3, 100054
  • Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53

    Authors: Lindzen M., Ghosh S., Noronha A., Drago D., Nataraj N. B., Leitner O., Carvalho S., Zmora E., Sapoznik S., Shany K. B., Levanon K., Aderka D., Ramírez B. S., Dahlhoff M., McNeish I. & Yarden Y. (2021), Oncogene. 40, 21, p. 3665-3679
  • Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

    Authors: Spencer C. N., McQuade J. L., Gopalakrishnan V., McCulloch J. A., Vetizou M., Cogdill A. P., Khan M. A. W., Zhang X., White M. G., Peterson C. B., Wong M. C., Morad G., Rodgers T., Badger J. H., Helmink B. A., Andrews M. C., Rodrigues R. R., Morgun A., Kim Y. S., Roszik J., Hoffman K. L., Zheng J., Zhou Y., Medik Y. B., Kahn L. M., Johnson S., Hudgens C. W., Wani K., Gaudreau P., Harris A. L., Jamal M. A., Baruch E. N., Perez-Guijarro E., Day C., Merlino G., Pazdrak B., Lochmann B. S., Szczepaniak-Sloane R. A., Arora R., Anderson J., Zobniw C. M., Posada E., Sirmans E., Simon J., Haydu L. E., Burton E. M., Wang L., Dang M., Clise-Dwyer K., Schneider S., Chapman T., Anang N. A. S., Duncan S., Toker J., Malke J. C., Glitza I. C., Amaria R. N., Tawbi H. A., Diab A., Wong M. K., Patel S. P., Woodman S. E., Davies M. A., Ross M. I., Gershenwald J. E., Lee J. E., Hwu P., Jensen V., Samuels Y., Straussman R., Ajami N. J., Nelson K. C., Nezi L., Petrosino J. F., Futreal P. A., Lazar A. J., Hu J., Jenq R. R., Tetzlaff M. T., Yan Y., Garrett W. S., Huttenhower C., Sharma P., Watowich S. S., Allison J. P., Cohen L., Trinchieri G., Daniel C. R. & Wargo J. A. (2021), Science. 374, 6575, p. 1632-1640
  • Systematic detection of m6A-modified transcripts at single-molecule and single-cell resolution

    Authors: Kim K. L., van Galen P., Hovestadt V., Rahme G. J., Andreishcheva E. N., Shinde A., Gaskell E., Jones D. R., Shema E. & Bernstein B. E. (2021), Cell Reports Methods. 1, 5, 100061
  • Deuterium MRSI characterizations of glucose metabolism in orthotopic pancreatic cancer mouse models

    Authors: Markovic S., Roussel T., Agemy L., Sasson K., Preise D., Scherz A. & Frydman L. (2021), NMR in Biomedicine. e4569
  • Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression

    Authors: Barnabas G. D., Lee J. S., Shami T., Harel M., Beck L., Selitrennik M., Jerby-Arnon L., Erez N., Ruppin E. & Geiger T. (2021), Cancer research (Chicago, Ill.). 81, 6, p. 1443-1456
  • Effect of ibrutinib on the ifn response of chronic lymphocytic leukemia cells

    Authors: Xia M., Luo T. Y., Shi Y., Wang G., Tsui H., Harari D. & Spaner D. E. (2020), The Journal of immunology (1950). 205, 10, p. 2629-2639
  • Stromal Expression of the Core Clock Gene Period 2 Is Essential for Tumor Initiation and Metastatic Colonization

    Authors: Shaashua L., Mayer S., Lior C., Lavon H., Novoselsky A. & Scherz-Shouval R. (2020), Frontiers in Cell and Developmental Biology. 8, 587697
  • Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation

    Authors: Wu Y., Chou T., Young L., Hsieh F., Pan H., Mo S., Brown S. B., Chen R., Kimchi A. & Lai M. (2020), Cell Death & Disease. 11, 305
  • The microbiome and cytosolic innate immune receptors

    Authors: Liwinski T., Zheng D. & Elinav E. (2020), Immunological Reviews. 1, p. 207-224
  • Myotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma

    Authors: Weidner P., Soehn M., Schroeder T., Helm L., Hauber V., Gutting T., Betge J., Roecken C., Rohrbacher F. N., Pattabiraman V. R., Bode J. W., Seger R., Saar D., Nunes-Alves A., Wade R. C., Ebert M. P. A. & Burgermeister E. (2020), Oncogenesis. 9, 6, 59
  • Regulation of eIF2α by RNF4 Promotes Melanoma Tumorigenesis and Therapy Resistance

    Authors: Avitan-Hersh E., Feng Y., Oknin Vaisman A., Abu Ahmad Y., Zohar Y., Zhang T., Lee J. S., Lazar I., Sheikh Khalil S., Feiler Y., Kluger H., Kahana C., Brown K., Ruppin E., Ronai Z. A. & Orian A. (2020), Journal of Investigative Dermatology. 12, p. 2466-2477
  • Modeling Multiplexed Images with Spatial-LDA Reveals Novel Tissue Microenvironments

    Authors: Chen Z., Soifer I., Hilton H., Keren L. & Jojic V. (2020), Journal of Computational Biology. 8, p. 1204-1218
  • Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma

    Authors: Kalaora S., Lee J. S., Barnea E., Levy R., Greenberg P., Alon M., Yagel G., Bar Eli G., Oren R., Peri A., Patkar S., Bitton L., Rosenberg S. A., Lotem M., Levin Y., Admon A., Ruppin E. & Samuels Y. (2020), Nature Communications. 11, 1, 896
  • Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

    Authors: Kinker G. S., Greenwald A. C., Tal R., Orlova Z., Cuoco M. S., McFarland J. M., Warren A., Rodman C., Roth J. A., Bender S. A., Kumar B., Rocco J. W., Fernandes P. A., Mader C. C., Keren-Shaul H., Plotnikov A., Barr H., Tsherniak A., Rozenblatt-Rosen O., Krizhanovsky V., Puram S. V., Regev A. & Tirosh I. (2020), Nature Genetics. 52, 11, p. 1208-1218
  • Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation

    Authors: Schwartz M., Portugez A. S., Attia B. Z., Tannenbaum M., Cohen L., Loza O., Chase E., Turman Y., Kaplan T., Salah Z. & Hakim O. (2020), Communications Biology. 3, 1, 696
  • A single cell atlas of the human liver tumor microenvironment

    Authors: Massalha H., Bahar Halpern K., Abu-Gazala S., Jana T., Massasa E. E., Moor A. E., Buchauer L., Rozenberg M., Pikarsky E., Amit I., Zamir G. & Itzkovitz S. (2020), Molecular Systems Biology. 16, 12, 9682
  • Induction and characterization of pancreatic cancer in a transgenic pig model

    Authors: Edward Boas F., Nurili F., Bendet A., Cheleuitte-Nieves C., Basturk O., Askan G., Michel A. O., Monette S., Ziv E., Sofocleous C. T., Maxwell A. W., Schook L. B., Solomon S. B., Kelsen D. P., Scherz A. & Yarmohammadi H. (2020), PLoS ONE. 15, 9, e0239391
  • Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor-Thr(701) phosphorylation

    Authors: Gaviraghi M., Rabellino A., Andolfo A., Brand M., Brombin C., Bagnato P., De Feudis G., Raimondi A., Locatelli A., Tosoni D., Mazza D., Gianni L., Tonon G., Yarden Y., Tacchetti C. & Daniele T. (2020), Scientific Reports. 10, 16906
  • Mutant p53 oncogenicity: dominant-negative or gain-of-function?

    Authors: Stein Y., Aloni-Grinstein R. & Rotter V. (2020), Carcinogenesis. 41, 12, p. 1635-1647
  • Developments in Vascular-Targeted Photodynamic Therapy for Urologic Malignancies

    Authors: Nogueira L., Tracey A. T., Alvim R., Reisz P., Scherz A., Coleman J. A. & Kim K. (2020), Molecules (Basel, Switzerland). 25, 22, 5417
  • The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma

    Authors: Gamaev L., Mizrahi L., Friehmann T., Rosenberg N., Pappo O., Olam D., Zeira E., Bahar Halpern, K., Caruso S., Zucman-Rossi J., Axelrod J. H., Galun E. & Goldenberg D. S. (2020), Oncogene. 40, 1, p. 127-139
  • Predicting and affecting response to cancer therapy based on pathway-level biomarkers

    Authors: Ben-Hamo R., Berger A. J., Gavert N., Miller M., Pines G., Oren R., Pikarsky E., Benes C. H., Neuman T., Zwang Y., Efroni S., Getz G. & Straussman R. (2020), Nature Communications. 11, 1, 3296
  • Genome-wide association study identifies 16 genomic regions associated with circulating cytokines at birth

    Authors: Wang Y., Nudel R., Benros M. E., Skogstrand K., Fishilevich S. & Lancet D. (2020), PLoS Genetics. 16, 11, 1009163
  • Targeting HER3, a Catalytically Defective Receptor Tyrosine Kinase, Prevents Resistance of Lung Cancer to a Third-Generation EGFR Kinase Inhibitor

    Authors: Romaniello D., Marrocco I., Nataraj N. B., Ferrer I., Drago-Garcia D., Vaknin I., Oren R., Lindzen M., Ghosh S., Kreitman M., Kittel J. C., Gaborit N., Baez G. B., Sanchez B., Eilam R., Pikarsky E., Paz-Ares L. & Yarden Y. (2020), Cancers. 12, 9, 2394
  • A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma

    Authors: Nagler A., Vredevoogd D. W., Alon M., Cheng P. F., Trabish S., Kalaora S., Arafeh R., Goldin V., Levesque M. P., Peeper D. S. & Samuels Y. (2020), Pigment Cell and Melanoma Research. 33, 2, p. 334-344
  • Interleukin 10 Restores Lipopolysaccharide-Induced Alterations in Synaptic Plasticity Probed by Repetitive Magnetic Stimulation

    Authors: Lenz M., Eichler A., Kruse P., Strehl A., Rodriguez-Rozada S., Goren I., Yogev N., Frank S., Waisman A., Deller T., Jung S., Maggio N. & Vlachos A. (2020), Frontiers in Immunology. 11, 614509
  • Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death

    Authors: Park S., Park H., Park S., Hong S. M., Yoon S., Morgan M. J. & Kim Y. (2020), Cell Death & Disease. 11, 9, 744
  • Mitochondrial carrier homolog 2 is necessary for AML survival

    Authors: Khan D. H., Mullokandov M., Wu Y., Voisin V., Gronda M. V., Hurren R., Wang X., MacLean N., Jeyaraju D. V., Jitkova Y., Xu G. W., Laister R. C., Seneviratne A., Blatman Z., Ketala T., Bader G. D., Marhon S. A., Carvalho D. D. D., Minden M. D., Gross A. & Schimmer A. D. (2020), Blood. 136, 1, p. 81-92
  • A framework for advancing our understanding of cancer-associated fibroblasts

    Authors: Sahai E., Astsaturov I., Cukierman E., DeNardo D. G., Egeblad M., Evans R. M., Fearon D., Greten F. R., Hingorani S. R., Hunter T., Hynes R. O., Jain R. K., Janowitz T., Jorgensen C., Kimmelman A. C., Kolonin M. G., Maki R. G., Powers R. S., Pure E., Ramirez D. C., Scherz-Shouval R., Sherman M. H., Stewart S., Tlsty T. D., Tuveson D. A., Watt F. M., Weaver V., Weeraratna A. T. & Werb Z. (2020), Nature Reviews Cancer. 20, 3, p. 174-186
  • A single-cell landscape of high-grade serous ovarian cancer

    Authors: Izar B., Tirosh I., Stover E. H., Wakiro I., Cuoco M. S., Alter I., Rodman C., Leeson R., Su M., Shah P., Iwanicki M., Walker S. R., Kanodia A., Melms J. C., Mei S., Lin J., Porter C. B. M., Slyper M., Waldman J., Jerby-Arnon L., Ashenberg O., Brinker T. J., Mills C., Rogava M., Vigneau S., Sorger P. K., Garraway L. A., Konstantinopoulos P. A., Liu J. F., Matulonis U., Johnson B. E., Rozenblatt-Rosen O., Rotem A. & Regev A. (2020), Nature Medicine. 26, 8, p. 1271-1279
  • Rational design of universal immunotherapy for TfR1-tropic arenaviruses

    Authors: Cohen-Dvashi H., Amon R., Agans K. N., Cross R. W., Borenstein-Katz A., Mateo M., Baize S., Padler-Karavani V., Geisbert T. W. & Diskin R. (2020), Nature Communications. 11, 1, 67
  • Immune related proteins and tumor infiltrating CD8+lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (HPV) and clinical outcome

    Authors: Landin D., Ahrlund-Richter A., Mirzaie L., Mints M., Nasman A., Kolev A., Marklund L., Dalianis T., Munck-Wikland E. & Ramqvist T. (2020), Head and Neck. 42, 11, p. 3206-3217
  • Pleiotropic tumor suppressor functions of WWOX antagonize metastasis

    Authors: Khawaled S., Nigita G., Distefano R., Oster S., Suh S., Smith Y., Khalaileh A., Peng Y., Croce C. M., Geiger T., Seewaldt V. L. & Aqeilan R. I. (2020), Signal Transduction and Targeted Therapy. 5, 1, 43
  • NF-κB-miR-155 axis activation mediates ovulation-induced oncogenic effects in fallopian tube epithelium

    Authors: Brand H., Barnabas G. D., Sapoznik S., Bahar-Shany K., Pozniak Y., Yung Y., Hourvitz A., Geiger T., Jacob-Hirsch J. & Levanon K. (2020), Carcinogenesis (New York). 41, 12, p. 1703-1712
  • Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts

    Authors: Kim K., Hu W., Audenet F., Almassi N., Hanrahan A. J., Murray K., Bagrodia A., Wong N., Clinton T. N., Dason S., Mohan V., Jebiwott S., Nagar K., Gao J., Penson A., Hughes C., Gordon B., Chen Z., Dong Y., Watson P. A., Alvim R., Elzein A., Gao S. P., Cocco E., Santin A. D., Ostrovnaya I., Hsieh J. J., Sagi I., Pietzak E. J., Hakimi A. A., Rosenberg J. E., Iyer G., Vargas H. A., Scaltriti M., Al-Ahmadie H., Solit D. B. & Coleman J. A. (2020), Nature Communications. 11, 1, 1975
  • Optimal multiparametric set-up modelled for best survival outcomes in palliative treatment of liver malignancies: unsupervised machine learning and 3 PM recommendations

    Authors: Goldstein E., Yeghiazaryan K., Ahmad A., Giordano F. A., Froehlich H. & Golubnitschaja O. (2020), EPMA Journal. 11, 3, p. 505-515
  • Single-cell analysis of clonal maintenance of transcriptional and epigenetic states in cancer cells

    Authors: Meir Z., Mukamel Z., Chomsky E., Lifshitz A. & Tanay A. (2020), Nature Genetics. 52, 7, p. 709-718
  • Immunomodulatory Properties of Leishmania Extracellular Vesicles During Host-Parasite Interaction: Differential Activation of TLRs and NF-kappa B Translocation by Dermotropic and Viscerotropic Species

    Authors: Nogueira P. M., de Menezes-Neto A., Borges V. M., Descoteaux A., Torrecilhas A. C., Xander P., Revach O., Regev-Rudzki N. & Soares R. P. (2020), Frontiers in Cellular and Infection Microbiology. 10, 380
  • The Glioma Stem Cell Model in the Era of Single-Cell Genomics

    Authors: Suva M. L. & Tirosh I. (2020), Cancer Cell. 37, 5, p. 630-636
  • Inter-Tumor Heterogeneity-Melanomas Respond Differently to GM-CSF-Mediated Activation

    Authors: Moshe A., Izraely S., Sagi-Assif O., Malka S., Ben-Menachem S., Meshel T., Pasmanik-Chor M., Hoon D. S. & Witz I. P. (2020), Cells. 9, 7, 1683
  • Microbiome genomics for cancer prediction

    Authors: Adlung L., Elinav E., Greten T. F. & Korangy F. (2020), Nature Cancer. 1, 4, p. 379-381
  • Breast Cancer-Derived Microparticles Reduce Cancer Cell Adhesion, an Effect Augmented by Chemotherapy

    Authors: Shechter D., Harel M., Mukherjee A., Sagredo L. M., Loven D., Prinz E., Avraham S., Orian-Rousseau V., Geiger T., Shaked Y. & Wolfenson H. (2020), Cells (Basel, Switzerland). 9, 10, 2269
  • Time-resolved profiling reveals ATF3 as a novel mediator of endocrine resistance in breast cancer

    Authors: Borgoni S., Sofyalı E., Soleimani M., Wilhelm H., Müller-Decker K., Will R., Noronha A., Beumers L., Verschure P. J., Yarden Y., Magnani L., van Kampen A. H., Moerland P. D. & Wiemann S. (2020), Cancers. 12, 10, 2918
  • CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

    Authors: Rosenblum D., Gutkin A., Kedmi R., Ramishetti S., Veiga N., Jacobi A. M., Schubert M. S., Friedmann-Morvinski D., Cohen Z. R., Behlke M. A., Lieberman J. & Peer D. (2020), Science advances. 6, 47, eabc9450
  • Effect of IV Administration of a Gadolinium-Based Contrast Agent on Breast Diffusion-Tensor Imaging

    Authors: Scaranelo A. M., Degani H., Grobgeld D., Talbot N., Bodolai K. & Furman-Haran E. (2020), American Journal of Roentgenology. 215, 4, p. 1030-1036
  • Nanobodies Targeting Prostate-specific Membrane Antigen for the Imaging and Therapy of Prostate Cancer

    Authors: Rosenfeld L., Sananes A., Zur Y., Cohen S., Dhara K., Gelkop S., Ben Zeev E., Shahar A., Lobel L., Akabayov B., Arbely E. & Papo N. (2020), Journal of Medicinal Chemistry. 63, 14, p. 7601-7615
  • Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models

    Authors: Feldman T., Grossman-Haham I., Elkis Y., Vilela P., Moskovits N., Barshack I., Salame T. M., Fass D. & Ilani T. (2020), Oncotarget. 11, 4, p. 386-398
  • Emerging roles of ECM remodeling processes in cancer

    Authors: Mohan V., Das A. & Sagi I. (2020), Seminars in Cancer Biology. 62, p. 192-200
  • Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody

    Authors: Cohen L., Sagi I., Bigelman E., Solomonov I., Aloshin A., Ben-Shoshan J., Rozenbaum Z., Keren G. & Entin-Meer M. (2020), PLoS ONE. 15, 4, e0231202
  • Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer's Disease Immunotherapy

    Authors: Castellani G. & Schwartz M. (2020), Trends in Immunology. 41, 9, p. 794-804
  • A Unified Linear Viscoelastic Model of the Cell Nucleus Defines the Mechanical Contributions of Lamins and Chromatin

    Authors: Wintner O., Hirsch-Attas N., Schlossberg M., Brofman F., Friedman R., Kupervaser M., Kitsberg D. & Buxboim A. (2020), Advanced Science. 7, 8, 1901222
  • The human tumor microbiome is composed of tumor type-specific intracellular bacteria

    Authors: Nejman D., Livyatan I., Fuks G., Gavert N., Zwang Y., Geller L. T., Rotter-Maskowitz A., Weiser R., Mallel G., Gigi E., Meltser A., Douglas G. M., Kamer I., Gopalakrishnan V., Dadosh T., Levin-Zaidman S., Avnet S., Atlan T., Cooper Z. A., Arora R., Cogdill A. P., Khan M. A. W., Ologun G., Bussi Y., Weinberger A., Lotan-Pompan M., Golani O., Perry G., Rokah M., Bahar-Shany K., Rozeman E. A., Blank C. U., Ronai A., Shaoul R., Amit A., Dorfman T., Kremer R., Cohen Z. R., Harnof S., Siegal T., Yehuda-Shnaidman E., Gal-Yam E. N., Shapira H., Baldini N., Langille M. G. I., Ben-Nun A., Kaufman B., Nissan A., Golan T., Dadiani M., Levanon K., Bar J., Yust-Katz S., Barshack I., Peeper D. S., Raz D. J., Segal E., Wargo J. A., Sandbank J., Shental N. & Straussman R. (2020), Science. 368, 6494, p. 973-980
  • The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy

    Authors: Wang X., Wang F., Zhong M., Yarden Y. & Fu L. (2020), Molecular Cancer. 19, 1, 81
  • Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge

    Authors: Shemer A., Scheyltjens I., Frumer G. R., Kim J., Grozovski J., Ayanaw S., Dassa B., Van Hove H., Chappell-Maor L., Boura-Halfon S., Leshkowitz D., Mueller W., Maggio N., Movahedi K. & Jung S. (2020), Immunity. 53, 5, p. 1033-1049.e7
  • IL-16 processing in sentinel node regulatory T cells is a factor in bladder cancer immunity

    Authors: Krantz D., Mints M., Winerdal M., Riklund K., Rutishauser D., Zubarev R., Zirakhzadeh A. A., Alamdari F., Johansson M., Sherif A. & Winqvist O. (2020), Scandinavian Journal of Immunology. 92, 6, e12926
  • Diffusion-weighted breast MRI of malignancies with submillimeter resolution and immunity to artifacts by spatiotemporal encoding at 3T

    Authors: Solomon E., Liberman G., Nissan N., Furman-Haran E., Sklair-Levy M. & Frydman L. (2020), Magnetic Resonance in Medicine. 84, 3, p. 1391-1403
  • Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma

    Authors: Parikh A., Shin J. H., Faquin W., Lin D. T., Tirosh I., Sunwoo J. B. & Puram S. V. (2020), Journal for ImmunoTherapy of Cancer. 8, 2, 001048
  • Increased circulatory IL-6 during 8-week fluoxetine treatment is a risk factor for suicidal behaviors in youth

    Authors: Amitai M., Taler M., Ben-Baruch R., Lebow M., Rotkopf R., Apter A., Fennig S., Weizman A. & Chen A. (2020), Brain Behavior And Immunity. 87, p. 301-308
  • Wnt/β-catenin target genes in colon cancer metastasis: The special case of l1cam

    Authors: Cheriyamundath S. & Ben-Ze’ev A. (2020), Cancers. 12, 11, 3444
  • Diffusivity in breast malignancies analyzed for b > 1000 s/mm 2 at 1 mm in‐plane resolutions: Insight from Gaussian and non‐Gaussian behaviors

    Authors: Otikovs M., Nissan N., Furman‐Haran E., Anaby D., Allweis T. M., Agassi R., Sklair‐Levy M. & Frydman L. (2020), Journal of Magnetic Resonance Imaging.
  • Single-cell genomic approaches for developing the next generation of immunotherapies

    Authors: Yofe I., Dahan R. & Amit I. (2020), Nature Medicine. 26, 2, p. 171-177
  • Lipid Transfer Proteins and Membrane Contact Sites in Human Cancer

    Authors: Peretti D., Kim S., Tufi R. & Lev S. (2020), Frontiers in Cell and Developmental Biology. 7, 371
  • Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature

    Authors: Tavor S., Shalit T., Chapal Ilani N., Moskovitz Y., Livnat N., Groner Y., Barr H., Minden M. D., Plotnikov A., Deininger M. W., Kaushansky N. & Shlush L. I. (2020), Haematologica. 105, 12, p. 2795-2804
  • Bystander IFN-gamma activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

    Authors: Thibaut R., Bost P., Milo I., Cazaux M., Lemaitre F., Garcia Z., Amit I., Breart B., Cornuot C., Schwikowski B. & Bousso P. (2020), Nature Cancer. 1, 3, p. 302-314
  • Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

    Authors: Mathew N. R., Vinnakota J. M., Apostolova P., Erny D., Hamarsheh S., Andrieux G., Kim J., Hanke K., Goldmann T., Chappell-Maor L., El-Khawanky N., Ihorst G., Schmidt D., Duyster J., Finke J., Blank T., Boerries M., Blazar B. R., Jung S., Prinz M. & Zeiser R. (2020), The Journal of Clinical Investigation. 130, 3, p. 1315-1329
  • A 20-Year Journey from Axonal Injury to Neurodegenerative Diseases and the Prospect of Immunotherapy for Combating Alzheimer's Disease

    Authors: Schwartz M., Ramos J. M. P. & Ben-Yehuda H. (2020), Journal of Immunology. 204, 2, p. 243-250
  • Intravital imaging of vascular anomalies and extracellular matrix remodeling in orthotopic pancreatic tumors

    Authors: Bochner F., Mohan V., Zinger A., Golani O., Schroeder A., Sagi I. & Neeman M. (2020), International Journal of Cancer. 146, 8, p. 2209-2217
  • High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies

    Authors: Haedicke K., Agemy L., Omar M., Berezhnoi A., Roberts S., Longo-Machado C., Skubal M., Nagar K., Hsu H., Kim K., Reiner T., Coleman J., Ntziachristos V., Scherz A. & Grimm J. (2020), Nature Biomedical Engineering. 4, 3, p. 286-297
  • A Division of Labor between YAP and TAZ in Non-Small Cell Lung Cancer

    Authors: Shreberk-Shaked M., Dassa B., Sinha S., Di Agostino S., Azuri I., Mukherjee S., Aylon Y., Blandino G., Ruppin E. & Oren M. (2020), Cancer Research. 80, 19, p. 4145-4157
  • High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function

    Authors: Grosheva I., Zheng D., Levy M., Polansky O., Lichtenstein A., Golani O., Dori-Bachash M., Moresi C., Shapiro H., Del Mare-Roumani S., Valdes-Mas R., He Y., Karbi H., Chen M., Harmelin A., Straussman R., Yissachar N., Elinav E. & Geiger B. (2020), Gastroenterology. 159, 5, p. 1807-1823
  • Identification of a potent and selective covalent Pin1 inhibitor

    Authors: Pinch B. J., Doctor Z. M., Nabet B., Browne C. M., Seo H., Mohardt M. L., Kozono S., Lian X., Manz T. D., Chun Y., Kibe S., Zaidman D., Daitchman D., Yeoh Z. C., Vangos N. E., Geffken E. A., Tan L., Ficarro S. B., London N., Marto J. A., Buratowski S., Dhe-Paganon S., Zhou X. Z., Lu K. P. & Gray N. S. (2020), Nature Chemical Biology. 16, 9, p. 979-987
  • Directed evolution of therapeutic antibodies targeting glycosylation in cancer

    Authors: Amon R., Rosenfeld R., Perlmutter S., Grant O. C., Yehuda S., Borenstein-Katz A., Alcalay R., Marshanski T., Yu H., Diskin R., Woods R. J., Chen X. & Padler-Karavani V. (2020), Cancers. 12, 10, 2824
  • DNA Repair Biomarker for Lung Cancer Risk and its Correlation With Airway Cells Gene Expression

    Authors: Paz-Elizur T., Leitner-Dagan Y., Meyer K. B., Markus B., Giorgi F. M., O'Reilly M., Kim H., Evgy Y., Fluss R., Freedman L. S., Rintoul R. C., Ponder B. & Livneh Z. (2020), Jnci cancer spectrum. 4, 1, pkz067
  • The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

    Authors: Kadosh E., Snir-Alkalay I., Venkatachalam A., May S., Lasry A., Elyada E., Zinger A., Shaham M., Vaalani G., Mernberger M., Stiewe T., Pikarsky E., Oren M. & Ben-Neriah Y. (2020), Nature. 7827, p. 133-+
  • Introducing PIONEER: a project to harness big data in prostate cancer research

    Authors: Omar M. I., Roobol M. J., Ribal M. J., Abbott T. & Lancet D. (2020), Nature Reviews Urology. 17, 6, p. 351-361
  • The potential anti-inflammatory and anti-nociceptive effects of rat hemopressin (PVNFKFLSH) in experimental arthritis

    Authors: Camargo L. L., Denadai-Souza A., Yshii L. M., Lima C., Teixeira S. A., Cerqueira A. R., Gewehr M. C., Fernandes E. S., Schenka A. A., Muscará M. N., Ferro E. S. & Costa S. K. (2020), European Journal of Pharmacology. 173636
  • Nasopharyngeal carcinoma joins the single-cell party

    Authors: Mints M. & Tirosh I. (2020),
  • Trypanosoma cruzi-Infected Human Macrophages Shed Proinflammatory Extracellular Vesicles That Enhance Host-Cell Invasion via Toll-Like Receptor 2

    Authors: Cronemberger-Andrade A., Xander P., Soares R. P., Pessoa N. L., Campos M. A., Ellis C. C., Grajeda B., Ofir-Birin Y., Almeida I. C., Regev-Rudzki N. & Torrecilhas A. C. (2020), Frontiers in Cellular and Infection Microbiology. 10, 99
  • Characterization of the human tumor microbiome reveals tumor-type specific intra-cellular bacteria

    Authors: Livyatan I., Nejman D., Shental N. & Straussman R. (2020), OncoImmunology. 9, 1, 1800957
  • beta-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus

    Authors: Zhang M., Lai Y., Krupalnik V., Guo P., Guo X., Zhou J., Xu Y., Yu Z., Liu L., Jiang A., Li W., Ma G., Li N., Fu X., Lv Y., Jiang M., Tariq M., Kanwal S., Liu H., Xu X., Zhang H., Huang Y., Wang L., Chen S., Babarinde I. A., Luo Z., Wang D., Zhou T., Ward C., He M., Ibanez D. P., Li Y., Zhou J., Yuan J., Feng Y., Arumugam K., Di Vicino U., Bao X., Wu G., Schambach A., Wang H., Sun H., Gao F., Qin B., Hutchins A. P., Doble B. W., Hartmann C., Cosma M. P., Qin Y., Xu G., Chen R., Volpe G., Chen L., Hanna J. H. & Esteban M. A. (2020), Science Advances. 6, 29, 1593
  • Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53-associated features

    Authors: Benor G., Fuks G., Chin S., Rueda O. M., Mukherjee S., Arandkar S., Aylon Y., Caldas C., Domany E. & Oren M. (2020), Molecular Oncology. 14, 8, p. 1640-1652
  • Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

    Authors: Lamballe F., Ahmad F., Vinik Y., Castellanet O., Daian F., Muller A., Kohler U. A., Bailly A., Josselin E., Castellano R., Cayrou C., Charafe-Jauffret E., Mills G. B., Geli V., Borg J., Lev S. & Maina F. (2020), Advanced Science. 3, 2003049
  • Mapping cell phenotypes in breast cancer

    Authors: Keren L. & Angelo M. (2020), Nature Reviews Cancer. 1, 2, p. 156-157
  • Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells

    Authors: Levite M., Zelig D., Friedman A., Ilouz N., Eilam R., Bromberg Z., Lasu A. A. R., Arbel-Alon S., Edvardson S., Tarshish M., Riek L. P., Lako R. L., Reubinoff B., Lebendiker M., Yaish D., Stavsky A. & Galun E. (2020), Journal of Autoimmunity. 112, 102462
  • Across the Globe: Proteogenomic Landscapes of Lung Cancer

    Authors: Yanovich-Arad G. & Geiger T. (2020), Cell. 182, 1, p. 9-11
  • Publisher Correction: Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome

    Authors: Shaashua L., Eckerling A., Israeli B., Yanovich G., Rosenne E., Fichman-Horn S., Zvi I. B., Sorski L., Haldar R., Satchi-Fainaro R., Geiger T., Sloan E. K. & Ben-Eliyahu S. (2020), BMC Biology. 18, 1, p. 198-198
  • Metabolic alterations in the tumor microenvironment and their role in oncogenesis

    Authors: Eisenberg L., Eisenberg-Bord M., Eisenberg-Lerner A. & Sagi-Eisenberg R. (2020), Cancer Letters. 484, p. 65-71
  • Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma

    Authors: Mur E. B., Bernardo S., Papon L., Mancini M., Fabbrizio E., Goussard M., Ferrer I., Giry A., Quantin X., Pujol J., Calvayrac O., Moll H. P., Glasson Y., Pirot N., Turtoi A., Canamero M., Wong K., Yarden Y., Casanova E., Soria J., Colinge J., Siebel C. W., Mazieres J., Favre G., Paz-Ares L. & Maraver A. (2020), Journal of Clinical Investigation. 130, 2, p. 612-624
  • Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

    Authors: Katzenelenbogen Y., Sheban F., Yalin A., Yofe I., Svetlichnyy D., Jaitin D. A., Bornstein C., Moshe A., Keren-Shaul H., Cohen M., Wang S., Li B., David E., Salame T., Weiner A. & Amit I. (2020), Cell. 182, 4, p. 872-885.e19
  • Targeting Metabolic Plasticity and flexibility Dynamics for Cancer Therapy

    Authors: Fendt S., Frezza C. & Erez A. (2020), Cancer Discovery. 10, 12, p. 1797-1807
  • Treatment of Multiple Myeloma Using Chimeric Antigen Receptor T Cells with Dual Specificity

    Authors: Levin A. G., Slobodkin M. R., Waks T., Horn G., Ninio-Many L., Unger N. D., Ohayon Y., Suliman S., Cohen Y., Tartakovsky B., Naparstek E., Avivi I. & Eshhar Z. (2020), Cancer Immunology Research. 8, 12, p. 1485-1495
  • NOP10 predicts lung cancer prognosis and its associated small nucleolar RNAs drive proliferation and migration

    Authors: Cui C., Liu Y., Gerloff D., Rohde C., Pauli C., Koehn M., Misiak D., Oellerich T., Schwartz S., Schmidt L., Wiewrodt R., Marra A., Hillejan L., Bartel F., Wickenhauser C., Huettelmaier S., Goellner S., Zhou F., Edemir B. & Mueller-Tidow C. (2020), Oncogene. 5, p. 909-921
  • The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice

    Authors: Shatz-Azoulay H., Vinik Y., Isaac R., Kohler U., Lev S. & Zick Y. (2020), Scientific Reports. 10, 1, 7375
  • Deconstructing tumor heterogeneity: the stromal perspective

    Authors: Vickman R. E., Faget D. V., Beachy P., Beebe D., Bhowmick N. A., Cukierman E., Deng W., Granneman J. G., Hildesheim J., Kalluri R., Lau K. S., Lengyel E., Lundeberg J., Moscat J., Nelson P. S., Pietras K., Politi K., Puré E., Scherz-Shouval R., Sherman M. H., Tuveson D., Weeraratna A. T., White R. M., Wong M. H., Woodhouse E. C., Zheng Y., Hayward S. W. & Stewart S. A. (2020), Oncotarget. 11, 40, p. 3621-3632
  • Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome

    Authors: Shaashua L., Eckerling A., Israeli B., Yanovich G., Rosenne E., Fichman-Horn S., Ben Zvi I., Sorski L., Haldar R., Satchi-Fainaro R., Geiger T., Sloan E. K. & Ben-Eliyahu S. (2020), BMC Biology. 18, 1, 163
  • Golgi organization is regulated by proteasomal degradation

    Authors: Eisenberg-Lerner A., Benyair R., Hizkiahou N., Nudel N., Maor R., Kramer M. P., Shmueli M. D., Zigdon I., Lev M. C., Ulman A., Sagiv J. Y., Dayan M., Dassa B., Rosenwald M., Shachar I., Li J., Wang Y., Dezorella N., Khan S., Shimoni E., Porat Z., Avinoam O. & Merbl Y. (2020), Nature Communications. 11, 1, 409
  • HSF1 and Molecular Chaperones in Biology and Cancer

    Authors: Mendillo M. L., Pincus D. & Scherz-Shouval R. (2020),
  • Roles for receptor tyrosine kinases in tumor progression and implications for cancer treatment

    Authors: Ghosh S., Marrocco I. & Yarden Y. (2020), Advances in Cancer Research. Fisher P. B. & Kumar R. (eds.). Vol. 147. p. 1-57
  • Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

    Authors: McFarland J. M., Paolella B. R., Warren A., Geiger-Schuller K., Shibue T., Rothberg M., Kuksenko O., Colgan W. N., Jones A., Chambers E., Dionne D., Bender S., Wolpin B. M., Ghandi M., Tirosh I., Rozenblatt-Rosen O., Roth J. A., Golub T. R., Regev A., Aguirre A. J., Vazquez F. & Tsherniak A. (2020), Nature Communications. 11, 1, 4296
  • Novel Proteome Extraction Method Illustrates a Conserved Immunological Signature of MSI-H Colorectal Tumors.

    Authors: Vainer E. D., Kania-Almog J., Zatara G., Levin Y. & Vainer G. W. (2020), Molecular & Cellular Proteomics. 19, 10, p. 1619-1631
  • Tumour heterogeneity and the evolutionary trade-offs of cancer

    Authors: Hausser J. & Alon U. (2020), Nature Reviews Cancer. 4, p. 247-257
  • Efficient targeted degradation via reversible and irreversible covalent PROTACs

    Authors: Gabizon R., Shraga A., Gehrtz P., Livnah E., Shorer Y., Gurwicz N., Avram L., Unger T., Aharoni H., Albeck S., Brandis A., Shulman Z., Katz B., Herishanu Y. & London N. (2020), Journal of the American Chemical Society. 142, 27, p. 11734-11742
  • PRMT1 inhibition induces differentiation of colon cancer cells

    Authors: Plotnikov A., Kozer N., Cohen G., Carvalho S., Duberstein S., Almog O., Solmesky L. J., Shurrush K. A., Babaev I., Benjamin S., Gilad S., Kupervaser M., Levin Y., Gershovits M., Ben-Avraham D. & Barr H. M. (2020), Scientific Reports. 10, 1, 20030
  • Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma

    Authors: Chen Y., Yin J., Li W., Li H., Chen D., Zhang C., Lv J., Wang Y., Li X., Li J., Zhang P., Li Y., He Q., Yang X., Lei Y., Tang L., Zhou G., Mao Y., Wei C., Xiong K., Zhang H., Zhu S., Hou Y., Sun Y., Dean M., Amit I., Wu K., Kuang D., Li G., Liu N. & Ma J. (2020), Cell Research. 11, p. 1024-1042
  • Intravital visualization of interactions of murine Peyer's patch-resident dendritic cells with M cells

    Authors: Kolesnikov M., Curato C., Zupancic E., Florindo H., Shakhar G. & Jung S. (2020), European Journal of Immunology. 4, p. 537-547
  • Cellular Origins of the Lymphatic Endothelium: Implications for Cancer Lymphangiogenesis: Implications for Cancer Lymphangiogenesis

    Authors: Gutierrez-Miranda L. & Yaniv K. (2020), Frontiers in Physiology. 11, 577584
  • Fluorescent Silica Nanoparticles to Label Metastatic Tumor Cells in Mineralized Bone Microenvironments

    Authors: Chiou A. E., Hinckley J. A., Khaitan R., Varsano N., Wang J., Malarkey H. F., Hernandez C. J., Williams R. M., Estroff L. A., Weiner S., Addadi L., Wiesner U. B. & Fischbach C. (2020), Small. 2001432
  • Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner

    Authors: Barak A. F., Lewinsky H., Perpinial M., Huber V., Radomir L., Kramer M. P., Sever L., Wolf Y., Shapiro M., Herishanu Y., Jung S., Becker-Herman S. & Shachar I. (2020), Oncogene. 39, 9, p. 1997-2008
  • Integration of intra-sample contextual error modeling for improved detection of somatic mutations from deep sequencing

    Authors: Abelson S., Zeng A. G., Nofech-Mozes I., Wang T. T., Ng S. W., Minden M. D., Pugh T. J., Awadalla P., Shlush L. I., Murphy T., Chan S. M., Dick J. E. & Bratman S. V. (2020), Science advances. 6, 50, 3722
  • Donor cell leukemia: reappearance of gene mutations in donor cells - more than an incidental phenomenon?

    Authors: Shahar Gabay T., Chapal-Ilani N., Moskovitz Y., Biezuner T., Oron B., Brilon Y., Fridman-Dror A., Sabah R., Balicer R., Tanay A., Mendelson-Cohen N., Dann E. J., Fineman R., Kaushansky N., Yehudai-Reshef S., Zuckerman T. & Shlush L. I. (2020), Haematologica. 105, 12, p. 2861-2863
  • Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response

    Authors: Vinik Y., Ortega F. G., Mills G. B., Lu Y., Jurkowicz M., Halperin S., Aharoni M., Gutman M. & Lev S. (2020), Science advances. 6, 40, eaba5714
  • Theileria parasites subvert E2F signaling to stimulate leukocyte proliferation

    Authors: Tretina K., Haidar M., Madsen-Bouterse S. A., Sakura T., Mfarrej S., Fry L., Chaussepied M., Pain A., Knowles D. P., Nene V. M., Ginsberg D., Daubenberger C. A., Bishop R. P., Langsley G. & Silva J. C. (2020), Scientific Reports. 10, 1, 3982
  • Hitting KRAS When It’s Down

    Authors: Gabizon R. & London N. (2020), Journal of Medicinal Chemistry. 63, 13, p. 6677-6678
  • Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis

  • Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression

    Authors: Parhi L., Alon-Maimon T., Sol A., Nejman D., Shhadeh A., Fainsod-Levi T., Yajuk O., Isaacson B., Abed J., Maalouf N., Nissan A., Sandbank J., Yehuda-Shnaidman E., Ponath F., Vogel J., Mandelboim O., Granot Z., Straussman R. & Bachrach G. (2020), Nature Communications. 11, 1, 3259
  • The Role of HSF1 and the Chaperone Network in the Tumor Microenvironment

    Authors: Grunberg N., Levi-Galibov O. & Scherz-Shouval R. (2020), HSF1 and Molecular Chaperones in Biology and Cancer. p. 101-111
  • PhISCS-BnB: a fast branch and bound algorithm for the perfect tumor phylogeny reconstruction problem

    Authors: Sadeqi Azer E., Rashidi Mehrabadi F., Malikić S., Li X. C., Bartok O., Litchfield K., Levy R., Samuels Y., Schäffer A. A., Gertz E. M., Day C. P., Pérez-Guijarro E., Marie K., Lee M. P., Merlino G., Ergun F. & Sahinalp S. C. (2020), Bioinformatics (Oxford, England). 36, suppl 1, p. i169-i176
  • Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

    Authors: Hoshino A., Kim H. S., Bojmar L., Gyan K. E., Cioffi M., Hernandez J., Zambirinis C. P., Rodrigues G., Molina H., Heissel S., Mark M. T., Steiner L., Benito-Martin A., Lucotti S., Di Giannatale A., Offer K., Nakajima M., Williams C., Nogués L., Pelissier Vatter F. A., Hashimoto A., Davies A. E., Freitas D., Kenific C. M., Ararso Y., Buehring W., Lauritzen P., Ogitani Y., Sugiura K., Takahashi N., Alečković M., Bailey K. A., Jolissant J. S., Wang H., Harris A., Schaeffer L. M., García-Santos G., Posner Z., Balachandran V. P., Khakoo Y., Raju G. P., Scherz A., Sagi I., Scherz-Shouval R., Yarden Y., Oren M., Malladi M., Petriccione M., De Braganca K. C., Donzelli M., Fischer C., Vitolano S., Wright G. P., Ganshaw L., Marrano M., Ahmed A., DeStefano J., Danzer E., Roehrl M. H. A., Lacayo N. J., Vincent T. C., Weiser M. R., Brady M. S., Meyers P. A., Wexler L. H., Ambati S. R., Chou A. J., Slotkin E. K., Modak S., Roberts S. S., Basu E. M., Diolaiti D., Krantz B. A., Cardoso F., Simpson A. L., Berger M., Rudin C. M., Simeone D. M., Jain M., Ghajar C. M., Batra S. K., Stanger B. Z., Bui J., Brown K. A., Rajasekhar V. K., Healey J. H., de Sousa M., Kramer K., Sheth S., Baisch J., Pascual V., Heaton T. E., La Quaglia M. P., Pisapia D. J., Schwartz R., Zhang H., Liu Y., Shukla A., Blavier L., DeClerck Y. A., LaBarge M., Bissell M. J., Caffrey T. C., Grandgenett P. M., Hollingsworth M. A., Bromberg J., Costa-Silva B., Peinado H., Kang Y., Garcia B. A., O'Reilly E. M., Kelsen D., Trippett T. M., Jones D. R., Matei I. R., Jarnagin W. R. & Lyden D. (2020), Cell. 182, 4, p. 1044-1061.e18
  • Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4(+) and PDPN+ CAFs to clinical outcome

    Authors: Friedman G., Levi-Galibov O., David E., Bornstein C., Giladi A., Dadiani M., Mayo A., Halperin C., Pevsner-Fischer M., Lavon H., Mayer S., Nevo R., Stein Y., Balint-Lahat N., Barshack I., Ali H. R., Caldas C., Nili-Gal-Yam E., Alon U., Amit I. & Scherz-Shouval R. (2020), Nature Cancer. 1, p. 692-708
  • Tackling the Many Facets of Glioblastoma Heterogeneity

    Authors: Tirosh I. & Suva M. L. (2020), Cell Stem Cell. 26, 3, p. 303-304
  • Nuclear P38: Roles in Physiological and Pathological Processes and Regulation of Nuclear Translocation

    Authors: Maik-Rachline G., Lifshits L. & Seger R. (2020), International Journal of Molecular Sciences. 21, 17, 6102
  • Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors

    Authors: Keshet R., Lee J. S., Adler L., Iraqi M., Ariav Y., Lim L. Q. J., Lerner S., Rabinovich S., Oren R., Katzir R., Tishler H. W., Stettner N., Goldman O., Landesman H., Galai S., Kuperman Y., Kuznetsov Y., Brandis A., Mehlman T., Malitsky S., Itkin M., Koehler S. E., Zhao Y., Talsania K., Shen T., Peled N., Ulitsky I., Porgador A., Ruppin E. & Erez A. (2020), Nature Cancer. 1, 9, p. 894-908
  • Recent insights into the role of L1CAM in cancer initiation and progression

    Authors: Altevogt P., Ben-Ze'ev A., Gavert N., Schumacher U., Schäfer H. & Sebens S. (2020), International Journal of Cancer. 147, 12, p. 3292-3296
  • Super-resolution Ultrasound Imaging

    Authors: Christensen-Jeffries K., Couture O., Dayton P. A., Eldar Y. C., Hynynen K., Kiessling F., O'Reilly M., Pinton I. G. F., Schmitz G., Tang M., Tanter M. & Van Sloun R. J. G. (2020), Ultrasound in Medicine and Biology. 46, 4, p. 865-891
  • Urinary Exosomes from Bladder Cancer Patients Show a Residual Cancer Phenotype despite Complete Pathological Downstaging

    Authors: Hiltbrunner S., Mints M., Eldh M., Rosenblatt R., Holmström B., Alamdari F., Johansson M., Veerman R. E., Winqvist O., Sherif A. & Gabrielsson S. (2020), Scientific Reports. 10, 1, p. 5960-5960, 5960
  • Leptin modulates gene expression in the heart and cardiomyocytes towards mitigating ischemia-induced damage

    Authors: Abd Alkhaleq H., Kornowski R., Waldman M., Levy E., Zemel R., Nudelman V., Shainberg A., Miskin R. & Hochhauser E. (2020), Experimental Cell Research. 397, 2, 112373
  • Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

    Authors: Levi-Galibov O., Lavon H., Wassermann-Dozorets R., Pevsner-Fischer M., Mayer S., Wershof E., Stein Y., Brown L. E., Zhang W., Friedman G., Nevo R., Golani O., Katz L. H., Yaeger R., Laish I., Porco J. A., Sahai E., Shouval D. S., Kelsen D. & Scherz-Shouval R. (2020), Nature Communications. 11, 6245
  • miR-17-92 and miR-106b-25 clusters regulate beta cell mitotic checkpoint and insulin secretion in mice

    Authors: Mandelbaum A. D., Kredo-Russo S., Aronowitz D., Myers N., Yanowski E., Klochendler A., Swisa A., Dor Y. & Hornstein E. (2019), Diabetologia. 62, 9, p. 1653-1666
  • Cooperativity between stromal cytokines drives the invasive migration of human breast cancer cells

    Authors: Elisha Y., Sagi Y., Klein G., Straussman R. & Geiger B. (2019), Philosophical Transactions of the Royal Society B: Biological Sciences. 374, 1779, 20180231
  • Author Correction: Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells (Scientific Reports, (2017), 7, 1, (16345), 10.1038/s41598-017-16558-0)

    Authors: Arafeh R., Flores K., Keren-Paz A., Maik-Rachline G., Gutkind N., Rosenberg S., Seger R. & Samuels Y. (2019),
  • Prediction of PD-L1 inhibition effects for HIV-infected individuals

    Authors: Zheltkova V., Argilaguet J., Peligero C., Bocharov G. & Meyerhans A. (2019), PLoS Computational Biology. 15, 11, 1007401
  • A universal anti-cancer vaccine: Chimeric invariant chain potentiates the inhibition of melanoma progression and the improvement of survival

    Authors: Sharbi-Yunger A., Grees M., Cafri G., Bassan D., Eichmuller S. B., Tzehoval E., Utikal J., Umansky V. & Eisenbach L. (2019), International Journal of Cancer. 144, 4, p. 909-921
  • Tumor diversity and the trade-off between universal cancer tasks

    Authors: Hausser J., Szekely P., Bar N., Zimmer A., Sheftel H., Caldas C. & Alon U. (2019), Nature Communications. 10, 5423
  • Imaging of Red-Shifted Light From Bioluminescent Tumors Using Fluorescence by Unbound Excitation From Luminescence

    Authors: Sonego F., Bouccara S., Pons T., Lequeux N., Danckaert A., Tinevez J., Alam I. S., Shorte S. L. & Tournebize R. (2019), Frontiers in Bioengineering and Biotechnology. 7, APR, p. 73, 73
  • Adipocytes sensitize melanoma cells to environmental TGF-beta cues by repressing the expression of miR-211

    Authors: Golan T., Parikh R., Jacob E., Vaknine H., Zemser-Werner V., Hershkovitz D., Malcov H., Leibou S., Reichman H., Sheinboim D., Percik R., Amar S., Brenner R., Greenberger S., Kung A., Khaled M. & Levy C. (2019), Science Signaling. 12, 591, 6847
  • Inhibition of a pancreatic cancer model by cooperative pairs of clinically approved and experimental antibodies

    Authors: Maron R., Schechter B., Nataraj N. B., Ghosh S., Romaniello D., Marrocco I., Noronha A., Carvalho S., Yarden Y. & Sela M. (2019), Biochemical and Biophysical Research Communications. 513, 1, p. 219-225
  • Cancer exome-based identification of tumor neo-antigens using mass spectrometry

  • Immunohistochemical quantification of partial-EMT in oral cavity squamous cell carcinoma primary tumors is associated with nodal metastasis

    Authors: Parikh A. S., Puram S. V., Faquin W. C., Richmon J. D., Emerick K. S., Deschler D. G., Varvares M. A., Tirosh I., Bernstein B. E. & Lin D. T. (2019), Oral Oncology. 99, 104458
  • SLAMF9 regulates pDC homeostasis and function in health and disease

    Authors: Sever L., Radomir L., Strim K., Weiner A., Shchottlender N., Lewinsky H., Barak A. F., Friedlander G., Ben-Dor S., Becker-Herman S. & Shachar I. (2019), Proceedings of the National Academy of Sciences of the United States of America. 116, 33, p. 16489-16496
  • Long Noncoding RNA MALAT1 Regulates Cancer Glucose Metabolism by Enhancing mTOR-Mediated Translation of TCF7L2

    Authors: Malakar P., Stein I., Saragovi A., Winkler R., Stern-Ginossar N., Berger M., Pikarsky E. & Karni R. (2019), Cancer Research. 79, 10, p. 2480-2493
  • Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities

    Authors: Sana G., Madigan J. P., Gartner J. J., Fourrez M., Lin J., Qutob N., Narayan J., Shukla S., Ambudkar S. V., Xia D., Rosenberg S. A., Gottesman M. M., Samuels Y. & Gillet J. (2019), Journal of Investigative Dermatology. 139, 9, p. 1985-1992
  • SLAMF receptors on normal and malignant B cells

    Authors: Shachar I., Barak A., Lewinsky H., Sever L. & Radomir L. (2019), Clinical Immunology. 204, p. 23-30
  • The cancer microbiome

    Authors: Elinav E., Garrett W. S., Trinchieri G. & Wargo J. (2019), Nature Reviews Cancer. 19, 7, p. 371-376
  • Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges

    Authors: Suva M. L. & Tirosh I. (2019), Molecular Cell. 75, 1, p. 7-12
  • AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer

    Authors: Kubli S. P., Bassi C., Roux C., Wakeham A., Gobl C., Zhou W., Jafari S. M., Snow B., Jones L., Palomero L., Thu K. L., Cassetta L., Soong D., Berger T., Ramachandran P., Baniasadi S. P., Duncan G., Lindzen M., Yarden Y., Herranz C., Lazaro C., Chu M. F., Haight J., Tinto P., Silvester J., Cescon D. W., Petit A., Pettersson S., Pollard J. W., Mak T. W., Pujana M. A., Cappello P. & Gorrini C. (2019), Proceedings of the National Academy of Sciences. 116, 9, p. 3604-3613
  • Deciphering Human Tumor Biology by Single-Cell Expression Profiling

  • PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

    Authors: Rosenzweig N., Dvir-Szternfeld R., Tsitsou-Kampeli A., Keren-Shaul H., Ben-Yehuda H., Weill-Raynal P., Cahalon L., Kertser A., Baruch K., Amit I., Weiner A. & Schwartz M. (2019), Nature Communications. 10, 465
  • The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids

    Authors: Seneviratne A. K., Xu M., Henao J. J. A., Fajardo V. A., Hao Z., Voisin V., Xu G. W., Hurren R., Kim S., MacLean N., Wang X., Gronda M., Jeyaraju D., Jitkova Y., Ketela T., Mullokandov M., Sharon D., Thomas G., Chouinard-Watkins R., Hawley J. R., Schafer C., Yau H. L., Khuchua Z., Arnan A., Al-awar R., Gross A., Claypoo S. M., Bazinet R., Lupien M., Chan S., De Carvalho D. D., Minden M. D., Bader G. D., Stark K. D., LeBlanc P. & Schimmer A. D. (2019), Cell Stem Cell. 24, 4, p. 621-636
  • KLF4 sensitizes the colon cancer cell HCT-15 to cisplatin by altering the expression of HMGB1 and hTERT

    Authors: Yadav S. S., Kumar M., Varshney A. & Yadava P. K. (2019), Life Sciences. 220, p. 169-176
  • Kinetic modeling of DUSP regulation in herceptin-resistant HER2-positive breast cancer

    Authors: Buiga P., Elson A., Tabernero L. & Schwartz J. M. (2019), Genes. 10, 8, 568
  • In vivo effects of temperature on the heart and pyloric rhythms in the crab Cancer borealis

    Authors: Kushinsky D., Morozova E. O. & Marder E. (2019), Journal of Experimental Biology. 222, 5, jeb199190.
  • RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction

    Authors: Ptasinska A., Pickin A., Assi S. A., Chin P. S., Ames L., Avellino R., Groeschel S., Delwel R., Cockerill P. N., Osborne C. S. & Bonifer C. (2019), Cell Reports. 28, 12, p. 3022-3031.e7
  • Liver and Steroid Hormones - Can a Touch of p53 Make a Difference?

    Authors: Charni-Natan M., Aloni-Grinstein R., Osher E. & Rotter V. (2019), Frontiers in Endocrinology. 10, 374
  • Genome-wide miRNA methylome analysis in oral cancer: possible biomarkers associated with patient survival

    Authors: Roy R., Chatterjee A., Das D., Ray A., Singh R., Chattopadhyay E., De Sarkar N., Eccles M., Pal M., Maitra A. & Roy B. (2019), Epigenomics. 11, 5, p. 473-487
  • Transient p53-Mediated Regenerative Senescence in the Injured Heart

    Authors: Sarig R., Rimmer R., Bassat E., Zhang L., Umansky K. B., Lendengolts D., Perlmoter G., Yaniv K. & Tzahor E. (2019),
  • Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells (vol 8, 653, 2018): RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells (Scientific Reports, (2018), 8, 1, (653), 10.1038/s41598-017-18851-4)

    Authors: Qutob N., Masuho I., Alon M., Emmanuel R., Cohen I., Di Pizio A., Madore J., Elkahloun A., Ziv T., Levy R., Gartner J. J., Hill V. K., Lin J. C., Hevroni Y., Greenberg P., Brodezki A., Rosenberg S. A., Kosloff M., Hayward N. K., Admon A., Niv M. Y., Scolyer R. A., Martemyanov K. A. & Samuels Y. (2019),
  • Hepatitis C virus core protein interacts with cellular metastasis suppressor Nm23-H1 and promotes cell migration and invasion

    Authors: Paul C., Khera L. & Kaul R. (2019), Archives of Virology. 164, p. 1271-1285
  • Corrigendum to 'p53 balances between tissue hierarchy and anarchy'

    Authors: Koifman G., Aloni-Grinstein R. & Rotter V. (2019),
  • Modelling the role of dual specificity phosphatases in herceptin resistant breast cancer cell lines

    Authors: Buiga P., Elson A., Tabernero L. & Schwartz J. (2019), Computational Biology and Chemistry. 80, p. 138-146
  • Increased expression of cathepsin D is required for L1-mediated colon cancer progression

    Authors: Basu S., Cheriyamundath S., Gavert N., Brabletz T., Haase G. & Ben-Ze'ev A. (2019), Oncotarget. 10, 50, p. 5217-5228
  • The role of the microbiome in NAFLD and NASH

    Authors: Kolodziejczyk A. A., Zheng D., Shibolet O. & Elinav E. (2019), EMBO Molecular Medicine. 11, 2, e9302
  • N-Acetyl-L-Cysteine Supplement in Early Life or Adulthood Reduces Progression of Diabetes in Nonobese Diabetic Mice

    Authors: Frenkel L. A., Rozenfeld H., Rozenberg K., Sampson S. R. & Rosenzweig T. (2019), Current Developments in Nutrition. 3, 4, 097
  • Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

    Authors: Li H., van der Leun A. M., Yofe I., Lubling Y., Gelbard-Solodkin D., van Akkooi A. C. J., van den Braber M., Rozeman E. A., Haanen J. B. A. G., Blank C. U., Horlings H. M., David E., Baran Y., Bercovich A., Lifshitz A., Schumacher T. N., Tanay A. & Amit I. (2019), Cell. 176, 4, p. 775-789.e18
  • Resistance to paclitaxel is associated with a variant of the gene BCL2 in multiple tumor types

    Authors: Ben-Hamo R., Zilberberg A., Cohen H., Bahar-Shany K., Wachtel C., Korach J., Aviel-Ronen S., Barshack I., Barash D., Levanon K. & Efroni S. (2019), npj Precision Oncology. 3, p. 12, 12
  • Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

    Authors: Alieva N. O., Efremov A. K., Hu S., Oh D., Chen Z., Natarajan M., Ong H. T., Jegou A., Romet-Lemonne G., Groves J. T., Sheetz M. P., Yan J. & Bershadsky A. D. (2019), Nature Communications. 10, 3593
  • Simultaneous Integration of Multi-omics Data Improves the Identification of Cancer Driver Modules

    Authors: Silverbush D., Cristea S., Yanovich-Arad G., Geiger T., Beerenwinkel N. & Sharan R. (2019), Cell Systems. 8, 5, p. 456-466.e5
  • Reduced CTL motility and activity in avascular tumor areas

    Authors: Manaster Y., Shipony Z., Hutzler A., Kolesnikov M., Avivi C., Shalmon B., Barshack I., Besser M. J., Feferman T. & Shakhar G. (2019), Cancer Immunology Immunotherapy. 68, 8, p. 1287-1301
  • The transcriptional profile of circulating myeloid derived suppressor cells correlates with tumor development and progression in mouse

    Authors: Nachmany I., Bogoch Y., Friedlander-Malik G., Amar O., Bondar E., Zohar N., Hantisteanu S., Fainaru O., Lubezky N., Klausner J. M. & Pencovich N. (2019), Genes and Immunity. 20, 7, p. 589-598
  • IKK epsilon regulates the breast cancer stem cell phenotype

    Authors: Orlova Z., Pruefer F., Castro-Oropeza R., Ordaz-Ramos A., Zampedri C., Maldonado V., Vazquez-Santillan K. & Melendez-Zajgla J. (2019), Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 4, p. 598-611
  • c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

    Authors: Sim W. J., Iyengar P. V., Lama D., Lui S. K. L., Ng H. C., Haviv-Shapira L., Domany E., Kappei D., Tan T. Z., Saie A., Jaynes P. W., Verma C. S., Kumar A. P., Rouanne M., Ha H. K., Radulescu C., ten Dijke P., Eichhorn P. J. A. & Thiery J. P. (2019), Nature Communications. 10, 4349
  • The landscape of tiered regulation of breast cancer cell metabolism

    Authors: Katzir R., Polat I. H., Harel M., Katz S., Foguet C., Selivanov V. A., Sabatier P., Cascante M., Geiger T. & Ruppin E. (2019), Scientific Reports. 9, 1, 17760
  • The ADAM17 Protease Promotes Tobacco Smoke Carcinogen-induced Lung Tumourigenesis

    Authors: Saad M. I., McLeod L., Yu L., Ebi H., Ruwanpura S., Sagi I., Rose-John S. & Jenkins B. J. (2019), Carcinogenesis. 4, p. 527-538
  • The therapeutic potential of tuftsin-phosphorylcholine in giant cell arteritis

    Authors: Croci S., Bonacini M., Muratore F., Caruso A., Fontana A., Boiardi L., Soriano A., Cavazza A., Cimino L., Belloni L., Perry O., Fridkin M., Parmeggiani M., Blank M., Shoenfeld Y. & Salvarani C. (2019), Journal of Autoimmunity. 98, p. 113-121
  • Proteomic and genomic signatures of repeat instability in cancer and adjacent normal tissues

    Authors: Persi E., Prandi D., Wolf Y. I., Pozniak Y., Barnabas G. D., Levanon K., Barshack I., Barbieri C., Gasperini P., Beltran H., Faltas B. M., Rubin M. A., Geiger T., Koonin E. V., Demichelis F. & Horn D. (2019), Proceedings of the National Academy of Sciences - PNAS. 116, 34, p. 16987-16996
  • Proteomic analysis reveals greater abundance of complement and inflammatory proteins in subcutaneous adipose tissue from postpartum cows treated with sodium salicylate

    Authors: Takiya C. S., Montgomery S. R., Mamedova L. K., Kra G., Nemes-Navon N., Levin Y., Fleming S. D., Bradford B. J. & Zachut M. (2019), Journal of Proteomics. 204, 103399
  • A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation

    Authors: Nuta G. C., Gilad Y., Gershoni M., Sznajderman A., Schlesinger T., Bialik S., Eisenstein M., Pietrokovski S. & Kimchi A. (2019), Autophagy. 15, 3, p. 438-452
  • Accelerated Hypofractionated Radiation Therapy for Elderly Frail Bladder Cancer Patients Unfit for Surgery or Chemotherapy

    Authors: Hammer L., Laufer M., Dotan Z., Leibowitz-Amit R., Berger R., Felder S., Weiss I., Lawrence Y. R. & Symon Z. (2019), American Journal Of Clinical Oncology-Cancer Clinical Trials. 42, 2, p. 179-183
  • Cross-Talk between Receptor Tyrosine Kinases AXL and ERBB3 Regulates Invadopodia Formation in Melanoma Cells

    Authors: Revach O., Sandler O., Samuels Y. & Geiger B. (2019), Cancer Research. 79, 10, p. 2634-2648
  • Daily light and darkness onset and circadian rhythms metabolically synchronize hematopoietic stem cell differentiation and maintenance: The role of bone marrow norepinephrine, tumor necrosis factor, and melatonin cycles

    Authors: Golan K., Kollet O., Markus R. P. & Lapidot T. (2019), Experimental Hematology. 78, p. 1-10
  • The circRNA-microRNA code: emerging implications for cancer diagnosis and treatment

    Authors: Verduci L., Strano S., Yarden Y. & Blandino G. (2019), Molecular Oncology. 13, 4, p. 669-680
  • Optimizing T-cell receptor avidity with somatic hypermutation

    Authors: Bassan D., Gozlan Y. M., Sharbi-Yunger A., Tzehoval E. & Eisenbach L. (2019), International Journal of Cancer. 145, 10, p. 2816-2826
  • Cancer immunotherapy: The dawn of antibody cocktails

    Authors: Marrocco I., Romaniello D. & Yarden Y. (2019), Human Monoclonal Antibodies. Steinitz M. S. (eds.). p. 11-51
  • Increased Expression of MicroRNA 551a by c-Fos Reduces Focal Adhesion Kinase Levels and Blocks Tumorigenesis

    Authors: Anuj, Arivazhagan L., Venkatraman G. & Rayala S. K. (2019), Molecular and Cellular Biology. 39, 7, UNSP e0057
  • Melanoma-derived extracellular vesicles instigate proinflammatory signaling in the metastatic microenvironment

    Authors: Lahav T. G., Adler O., Zait Y., Shani O., Amer M., Doron H., Abramovitz L., Yofe I., Cohen N. & Erez N. (2019), International Journal of Cancer. 145, 9, p. 2521-2534
  • Nonmuscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells

    Authors: Halder D., Saha S., Singh R. K., Ghosh I., Mallick D., Dey S. K., Ghosh A., Das B. B., Ghosh S. & Jana S. S. (2019), Molecular Biology of the Cell. 30, 12, p. 1463-1476
  • Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

    Authors: Conniot J., Scomparin A., Peres C., Yeini E., Pozzi S., Matos A., Kleiner R., Moura L. I. F., Zupancic E., Viana A. S., Doron H., Gois P. M. P., Erez N., Jung S., Satchi-Fainaro R. & Florindo H. F. (2019), Nature Nanotechnology. 14, 9, p. 891-901
  • p53: not just a tumor suppressor

  • Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis

    Authors: Stein Y., Rotter V. & Aloni-Grinstein R. (2019), International Journal of Molecular Sciences. 20, 24, 6197
  • ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

    Authors: Saad M. I., Alhayyani S., McLeod L., Yu L., Alanazi M., Deswaerte V., Tang K., Jarde T., Smith J. A., Prodanovic Z., Tate M. D., Balic J. J., Watkins D. N., Cain J. E., Bozinovski S., Algar E., Kohmoto T., Ebi H., Ferlin W., Garbers C., Ruwanpura S., Sagi I., Rose-John S. & Jenkins B. J. (2019), EMBO Molecular Medicine. 11, 4, 9976
  • RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma

    Authors: Arafeh R., Di Pizio A., Elkahloun A. G., Dym O., Niv M. Y. & Samuels Y. (2019),
  • UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

    Authors: Jachimowicz R. D., Beleggia F., Isensee J., Velpula B. B., Goergens J., Bustos M. A., Doll M. A., Shenoy A., Checa-Rodriguez C., Wiederstein J. L., Baranes-Bachar K., Bartenhagen C., Hertwig F., Teper N., Nishi T., Schmitt A., Distelmaier F., Lüdecke H., Albrecht B., Krüger M., Schumacher B., Geiger T., Hoon D. S., Huertas P., Fischer M., Hucho T., Peifer M., Ziv Y., Reinhardt H. C., Wieczorek D. & Shiloh Y. (2019), Cell. 176, 3, p. 505-519
  • Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer

    Authors: Shee K., Jiang A., Varn F. S., Liu S., Traphagen N. A., Owens P., Ma C. X., Hoog J., Cheng C., Golub T. R., Straussman R. & Miller T. W. (2019), FASEB Journal. 33, 2, p. 1644-1657
  • Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses

    Authors: Demarta-Gatsi C., Rivkin A., Di Bartolo V., Peronet R., Ding S., Commere P., Guillonneau F., Bellalou J., Brule S., Abou Karam P., Cohen S. R., Lagache T., Janse C. J., Regev-Rudzki N. & Mecheri S. (2019), Cellular Microbiology. 21, 7, e13021
  • An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

    Authors: Neftel C., Laffy J., Filbin M. G., Hara T., Shore M. E., Rahme G. J., Richman A. R., Silverbush D., Shaw M. L., Hebert C. M., Dewitt J., Gritsch S., Perez E. M., Castro L. N. G., Lan X., Druck N., Rodman C., Dionne D., Kaplan A., Bertalan M. S., Small J., Pelton K., Becker S., Bonal D., Quang-De Nguyen, Servis R. L., Fung J. M., Mylvaganam R., Mayr L., Gojo J., Haberler C., Geyeregger R., Czech T., Slavc I., Nahed B., Curry W. T., Carter B. S., Wakimoto H., Brastianos P. K., Batchelor T. T., Stemmer-Rachamimov A., Martinez-Lage M., Frosch M. P., Stamenkovic I., Riggi N., Rheinbay E., Monje M., Rozenblatt-Rosen O., Cahill D. P., Patel A. P., Hunter T., Verma I. M., Ligon K. L., Louis D. N., Regev A., Bernstein B. E., Tirosh I. & Suva M. L. (2019), Cell. 178, 4, p. 835-849.e21
  • ISG15 induction is required during L1-mediated colon cancer progression and metastasis

    Authors: Cheriyamundath S., Basu S., Haase G., Doernberg H., Gavert N., Brabletz T. & Ben-Ze’ev A. (2019), Oncotarget. 10, 67, p. 7122-7131
  • Single-cell sequencing and its applications in head and neck cancer

    Authors: Qi Z., Barrett T., Parikh A. S., Tirosh I. & Puram S. V. (2019), Oral Oncology. 99, 104441
  • Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection

    Authors: Barnabas G. D., Bahar-Shany K., Sapoznik S., Helpman L., Kadan Y., Beiner M., Weitzner O., Arbib N., Korach J., Perri T., Katz G., Blecher A., Brandt B., Friedman E., Stockheim D., Jakobson-Setton A., Eitan R., Armon S., Brand H., Zadok O., Aviel-Ronen S., Harel M., Geiger T. & Levanon K. (2019), Molecular & Cellular Proteomics. 18, 5, p. 865-875
  • Evolutionary trajectory of leukemic clones and its clinical implications

    Authors: Tuval A. & Shlush L. (2019), Haematologica. 104, 5, p. 872-880
  • Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer

    Authors: Maik-Rachline G., Hacohen A. & Seger R. (2019), International Journal of Molecular Sciences. 20, 5, 1194
  • Magnesium transporter 1 (MAGT1) deficiency causes selective defects in N-linked glycosylation and expression of immune-response genes

    Authors: Matsuda-Lennikov M., Biancalana M., Zou J., Ravell J. C., Zheng L., Kanellopoulou C., Jiang P., Notarangelo G., Jing H., Masutani E., Oler A. J., Olano L. R., Schulz B. L. & Lenardo M. J. (2019), Journal of Biological Chemistry. 294, 37, p. 13638-13656
  • Connections Between Clonal Hematopoiesis, Cardiovascular Disease, and Cancer A Review

    Authors: Calvillo-Arguelles O., Jaiswal S., Shlush L. I., Moslehi J. J., Schimmer A., Barac A. & Thavendiranathan P. (2019), JAMA Cardiology. 4, 4, p. 380-387
  • Specific inhibition of splicing factor activity by decoy RNA oligonucleotides

    Authors: Denichenko P., Mogilevsky M., Clery A., Welte T., Biran J., Shimshon O., Barnabas G. D., Danan-Gotthold M., Kumar S., Yavin E., Levanon E. Y., Allain F. H., Geiger T., Levkowitz G. & Karni R. (2019), Nature Communications. 10, 1590
  • Effectiveness of the combination of vascular targeted photodynamic therapy and anti-cytotoxic T-lymphocyte-associated antigen 4 in a preclinical mouse model of urothelial carcinoma

    Authors: Corradi R. B., LaRosa S., Jebiwott S., Murray K. S., Rosenzweig B., Somma A. J., Gomez R. S., Scherz A., Kim K. & Coleman J. A. (2019), International Journal of Urology. 26, 3, p. 414-422
  • New insights into YAP/TAZ nucleo-cytoplasmic shuttling: new cancer therapeutic opportunities?

    Authors: Shreberk-Shaked M. & Oren M. (2019), Molecular Oncology. 13, 6, p. 1335-1341
  • Bacillus Calmette-Guerin (BCG) therapy lowers the incidence of Alzheimer's disease in bladder cancer patients

    Authors: Gofrit O. N., Klein B. Y., Cohen I. R., Ben-Hur T., Greenblatt C. L. & Bercovier H. (2019), PLoS ONE. 14, 11, 0224433
  • UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

    Authors: Wolf Y., Bartok O., Patkar S., Eli G. B., Cohen S., Litchfield K., Levy R., Jiménez-Sánchez A., Trabish S., Lee J. S., Karathia H., Barnea E., Day C., Cinnamon E., Stein I., Solomon A., Bitton L., Pérez-Guijarro E., Dubovik T., Shen-Orr S. S., Miller M. L., Merlino G., Levin Y., Pikarsky E., Eisenbach L., Admon A., Swanton C., Ruppin E. & Samuels Y. (2019), Cell. 179, 1, p. 219-235
  • PIK3CA in cancer: The past 30 years

    Authors: Arafeh R. & Samuels Y. (2019), Seminars in Cancer Biology. 59, p. 36-49
  • Scaling laws indicate distinct nucleation mechanisms of holes in the nuclear lamina

    Authors: Deviri D., Pfeifer C. R., Dooling L. J., Ivanovska I. L., Discher D. E. & Safran S. A. (2019), Nature Physics. 15, 8, p. 823-829
  • Transmissible inflammation-induced colorectal cancer in inflammasome-deficient mice

    Authors: Hu B., Friedman G., Elinav E. & Flavell R. A. (2019), OncoImmunology. 8, 10, 981995
  • Exosomes as a storehouse of tissue remodeling proteases and mediators of cancer progression

    Authors: Das A., Mohan V., Krishnaswamy V. R., Solomonov I. & Sagi I. (2019), Cancer and Metastasis Reviews. 38, 3, p. 455-468
  • Modulation of MS-like disease by a multi epitope protein is mediated by induction of CD11c(+) CD1lb(+) Grl(+) myeloid-derived dendritic cells

    Authors: Kaushansky N., Kaminitz A., Allouche-Arnon H. & Ben-Nun A. (2019), Journal of Neuroimmunology. 333, 476953
  • MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy

    Authors: Owyong M., Chou J., van den Bijgaart R. J., Kong N., Efe G., Maynard C., Talmi-Frank D., Solomonov I., Koopman C., Hadler-Olsen E., Headley M., Lin C., Wang C., Sagi I., Werb Z. & Plaks V. (2019), Life Science Alliance. 2, 6, e201800226
  • Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes

    Authors: Sehrawat U., Koning F., Ashkenazi S., Stelzer G., Leshkowitz D. & Dikstein R. (2019), Molecular and Cellular Biology. 39, 3, e00441-18
  • STAT3 Post-Translational Modifications Drive Cellular Signaling Pathways in Prostate Cancer Cells

    Authors: Cocchiola R., Rubini E., Altieri F., Chichiarelli S., Paglia G., Romaniello D., Carissimi S., Giorgi A., Giamogante F., Macone A., Perugia G., Gurtner A. & Eufemi M. (2019), International Journal of Molecular Sciences. 20, 8, 1815
  • MicroRNAs Affect Complement Regulator Expression and Mitochondrial Activity to Modulate Cell Resistance to Complement-Dependent Cytotoxicity

    Authors: Hillman Y., Mardamshina M., Pasmanik-Chor M., Ziporen L., Geiger T., Shomron N. & Fishelson Z. (2019), Cancer Immunology Research. 7, 12, p. 1970-1983
  • Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

    Authors: Keskin D. B., Anandappa A. J., Sun J., Tirosh I., Mathewson N. D., Li S., Oliveira G., Giobbie-Hurder A., Felt K., Gjini E., Shukla S. A., Hu Z., Li L., Le P. M., Allesoe R. L., Richman A. R., Kowalczyk M. S., Abdelrahman S., Geduldig J. E., Charbonneau S., Pelton K., Iorgulescu J. B., Elagina L., Zhang W., Olive O., McCluskey C., Olsen L. R., Stevens J., Lane W. J., Salazar A. M., Daley H., Wen P. Y., Chiocca E. A., Harden M., Lennon N. J., Gabriel S., Getz G., Lander E. S., Regev A., Ritz J., Neuberg D., Rodig S. J., Ligon K. L., Suva M. L., Wucherpfennig K. W., Hacohen N., Fritsch E. F., Livak K. J., Ott P. A., Wu C. J. & Reardon D. A. (2019), Nature. 565, 7738, p. 234-239
  • The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

    Authors: De Mattos-Arruda L., Sammut S., Ross E. M., Bashford-Rogers R., Greenstein E., Markus H., Morganella S., Teng Y., Maruvka Y., Pereira B., Rueda O. M., Chin S., Contente-Cuomo T., Mayor R., Arias A., Ali H. R., Cope W., Tiezzi D., Dariush A., Amarante T. D., Reshef D., Ciriaco N., Martinez-Saez E., Peg V., Ramon y Cajal S., Cortes J., Vassiliou G., Getz G., Nik-Zainal S., Murtaza M., Friedman N., Markowetz F., Seoane J. & Caldas C. (2019), Cell Reports. 27, 9, p. 2690-2708
  • Potential immunotherapy for Alzheimer disease and age-related dementia

    Authors: Schwartz M., Arad M. & Ben-Yehuda H. (2019), Dialogues in Clinical Neuroscience. 21, 1, p. 21-25
  • Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

    Authors: Riquelme E., Zhang Y., Zhang L., Montiel M., Zoltan M., Dong W., Quesada P., Sahin I., Chandra V., San Lucas A., Scheet P., Xu H., Hanash S. M., Feng L., Burks J. K., Do K., Peterson C. B., Nejman D., Tzeng C. D., Kim M. P., Sears C. L., Ajami N., Petrosino J., Wood L. D., Maitra A., Straussman R., Katz M., White J. R., Jenq R., Wargo J. & McAllister F. (2019), Cell. 178, 4, p. 795-806, e1-e12
  • The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells

    Authors: Chan S. M., Sapir T., Park S., Rual J., Contreras-Galindo R., Reiner O. & Markovitz D. M. (2019), PLoS ONE. 14, 2, 0212970
  • Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein

    Authors: Bayart E., Flacco A., Delmas O., Pommarel L., Levy D., Cayallone M., Megnin-Chanet F., Deutsch E. & Malka V. A. (2019), Scientific Reports. 9, 10132
  • Biological implications of clonal hematopoiesis

    Authors: Luis T. C., Wilkinson A. C., Beerman I., Jaiswal S. & Shlush L. (2019), Experimental Hematology. 77, p. 1-5
  • Potentiating vascular-targeted photodynamic therapy through CSF-1R modulation of myeloid cells in a preclinical model of prostate cancer

    Authors: Lebdai S., Gigoux M., Alvim R., Somma A., Nagar K., Azzouzi A. R., Cussenot O., Merghoub T., Wolchok J. D., Scherz A., Kim K. & Coleman J. (2019), OncoImmunology. 8, 6, e1581528
  • Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer

    Authors: Hooda J., Novak M., Salomon M. P., Matsuba C., Ramos R. I., MacDuffie E., Song M., Hirsch M. S., Lester J., Parkash V., Karlan B. Y., Oren M., Hoon D. S. & Drapkin R. (2019), Cancer Research. 79, 4, p. 760-772
  • Mutant p53-a potential player in shaping the tumor-stroma crosstalk

    Authors: Stein Y., Aloni-Grinstein R. & Rotter V. (2019), Journal of Molecular Cell Biology. 11, 7, p. 600-604
  • Self-assembled micellar clusters based on Triton-X-family surfactants for enhanced solubilization, encapsulation, proteins permeability control, and anticancer drug delivery

    Authors: Solomonov A. V., Marfin Y. S., Rumyantsev E. V., Ragozin E., Zahavi T. S., Gellerman G., Tesler A. B., Muench F., Kumagai A. & Miyawaki A. (2019), Materials Science & Engineering: C-Materials For Biological Applications. 99, p. 794-804
  • RUNX represses Pmp22 to drive neurofibromagenesis

    Authors: Hall A., Choi K., Liu W., Rose J., Zhao C., Yu Y., Na Y., Cai Y., Coover R. A., Lin Y., Dombi E., Kim M., Levanon D., Groner Y., Boscolo E., Pan D., Liu P. P., Lu Q. R., Ratner N., Huang G. & Wu J. (2019), Science Advances. 5, 4, 8389
  • p53 balances between tissue hierarchy and anarchy

    Authors: Koifman G., Aloni-Grinstein R. & Rotter V. (2019), Journal of Molecular Cell Biology. 11, 7, p. 553-563
  • Facing the future: challenges and opportunities in adoptive T cell therapy in cancer

    Authors: Magalhaes I., Carvalho-Queiroz C., Hartana C. A., Kaiser A., Lukic A., Mints M., Nilsson O., Grönlund H., Mattsson J. & Berglund S. (2019), Expert Opinion on Biological Therapy. 19, 8, p. 811-827
  • Oxidative stress and therapeutic development in lung cancer

    Authors: Chowdhury A., Sarkar S., Ghosh S., Noronha A., Chakraborti T. & Chakraborti S. (2019), Oxidative Stress in Lung Diseases. Parinandi N. L., Ganguly N. K., Ghosh R., Chakraborti S. & Chakraborti T. (eds.). Vol. 2. p. 427-443
  • The integrated stress response promotes B7H6 expression

    Authors: Obiedat A., Charpak-Amikam Y., Tai-Schmiedel J., Seidel E., Mahameed M., Avril T., Stern-Ginossar N., Springuel L., Bolsee J., Gilham D. E., Dipta P., Shmuel M., Chevet E., Mandelboim O. & Tirosh B. (2019), Journal of Molecular Medicine. 98, 1, p. 135-148
  • Veto cells for safer nonmyeloablative haploidentical HSCT and CAR T cell therapy

    Authors: Reisner Y. & Or-Geva N. (2019), Seminars in Hematology. 56, 3, p. 173-182
  • Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

    Authors: Harel M., Ortenberg R., Varanasi S. K., Mangalhara K. C., Mardamshina M., Markovits E., Baruch E. N., Tripple V., Arama-Chayoth M., Greenberg E., Shenoy A., Ayasun R., Knafo N., Xu S., Anafi L., Yanovich-Arad G., Barnabas G. D., Ashkenazi S., Besser M. J., Schachter J., Bosenberg M., Shadel G. S., Barshack I., Kaech S. M., Markel G. & Geiger T. (2019), Cell. 179, 1, p. 236-250
  • Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression

    Authors: Luciani G. M., Xie L., Dilworth D., Tierens A., Moskovitz Y., Murison A., Szewczyk M. M., Mitchell A., Lupien M., Shlush L., Dick J. E., Arrowsmith C. H., Barsyte-Lovejoy D. & Minden M. D. (2019), Experimental Hematology. 69, p. 27-36
  • Can immunization with Bacillus Calmette-Guerin (BCG) protect against Alzheimer's disease?

    Authors: Gofrit O. N., Bercovier H., Klein B. Y., Cohen I. R., Ben-Hur T. & Greenblatt C. L. (2019), Medical Hypotheses. 123, p. 95-97
  • Global DNA methylation reflects spatial heterogeneity and molecular evolution of lung adenocarcinomas

    Authors: Dietz S., Lifshitz A., Kazdal D., Harms A., Endris V., Winter H., Stenzinger A., Warth A., Sill M., Tanay A. & Sueltmann H. (2019), International Journal of Cancer. 144, 5, p. 1061-1072
  • Hydrophobic Organic Components of Ambient Fine Particulate Matter (PM 2.5) Associated with Inflammatory Cellular Response.

    Authors: Jiang X., Xu F., Qiu X., Shi X., Pardo M., Shang Y., Wang J., Rudich Y. & Zhu T. (2019), Environmental Science & Technology. 53, 17, p. 10479-10486
  • Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer

    Authors: Silberman A., Goldman O., Assayag O. B., Jacob A., Rabinovich S., Adler L., Lee J. S., Keshet R., Sarver A., Frug J., Stettner N., Galai S., Persi E., Halpern K. B., Zaltsman-Amir Y., Pode-Shakked B., Eilam R., Anikster Y., Nagamani S. C. S., Ulitsky I., Ruppin E. & Erez A. (2019), Cancer Research. 79, 3, p. 518-533
  • Prediction of ultra-high-order antibiotic combinations based on pairwise interactions

    Authors: Katzir I., Cokol M., Aldridge B. B. & Alon U. (2019), PLoS Computational Biology. 15, 1, 1006774
  • Data on peptidyl platform-based anticancer drug synthesis and triton-x-based micellar clusters (MCs) self-assembly peculiarities for enhanced solubilization, encapsulation of hydrophobic compounds and their interaction with HeLa cells

    Authors: Solomonov A. V., Marfin Y. S., Rumyantsev E. V., Ragozin E., Zahavi T. S., Gellerman G., Tesler A. B., Muench F., Kumagai A. & Miyawaki A. (2019), Data in Brief. 25, 104052
  • Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression

    Authors: Reznik N., Kozer N., Eisenberg-Lerner A., Barr H., Merbl Y. & London N. (2019), ACS Chemical Biology. 14, 12, p. 2538-2545
  • Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy

    Authors: Lonetto G., Koifman G., Silberman A., Attery A., Solomon H., Levin-Zaidman S., Goldfinger N., Porat Z., Erez A. & Rotter V. (2019), Cell Death and Differentiation. 26, 9, p. 1566-1581
  • p53 and the Viral Connection: Back into the Future

    Authors: Aloni-Grinstein R., Charni-Natan M., Solomon H. & Rotter V. (2018), Cancers. 10, 6, 178
  • P53 shades of Hippo

    Authors: Furth N., Aylon Y. & Oren M. (2018), Cell Death and Differentiation. 25, p. 81-92
  • The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer

    Authors: Maik-Rachline G., Zehorai E., Hanoch T., Blenis J. & Seger R. (2018), Science Signaling. 11, 525, aao3428
  • Quantitative evaluation of breast cancer response to neoadjuvant chemotherapy by diffusion tensor imaging: Initial results

    Authors: Furman-Haran E., Nissan N., Ricart-Selma V., Martinez-Rubio C., Degani H. & Camps-Herrero J. (2018), Jmri-Journal Of Magnetic Resonance Imaging. 47, 4, p. 1080-1090
  • Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers

    Authors: Solomon H., Dinowitz N., Pateras I. S., Cooks T., Shetzer Y., Molchadsky A., Charni M., Rabani S., Koifman G., Tarcic O., Porat Z., Kogan-Sakin I., Goldfinger N., Oren M., Harris C. C., Gorgoulis V. G. & Rotter V. (2018), Oncogene. 37, 12, p. 1669-1684
  • Does cancer strive to minimize the cost of gene expression?

    Authors: Schirman D., Frumkin I. & Pilpel Y. (2018), Oncotarget. 9, 46, p. 27909-27910
  • Regulation of dual specificity phosphatases in breast cancer during initial treatment with Herceptin: a Boolean model analysis

    Authors: Buiga P., Elson A., Tabernero L. & Schwartz J. (2018), BMC Systems Biology. 12, Suppl 1, p. 13-24, 11
  • Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

    Authors: Yu Y., Schleich K., Yue B., Ji S., Lohneis P., Kemper K., Silvis M. S., Qutob N., van Rooijen E., Werner-Klein M., Li L., Dhawan D., Meierjohann S., Reimann M., Elkahloun A., Treitschke S., Dörken B., Speck C., Mallette F. A., Zon L. I., Holmen S. L., Peeper D. S., Samuels Y., Schmitt C. A. & Lee S. (2018), Cancer Cell. 33, 2, p. 322-336.e8
  • Quantification and tracking of genetically engineered dendritic cells for studying immunotherapy

    Authors: Bar-Shir A., Alon L., Korrer M. J., Lim H. S., Yadav N. N., Kato Y., Pathak A. P., Bulte J. W. M. & Gilad A. A. (2018), Magnetic Resonance in Medicine. 79, 2, p. 1010-1019
  • Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

    Authors: Filbin M. G., Tirosh I., Hovestadt V., Shaw M. L., Escalante L. E., Mathewson N. D., Neftel C., Frank N., Pelton K., Hebert C., Haberler C., Yizhak K., Gojo J., Egervari K., Mount C., van Galen P., Bonal D. M., Quang-De Nguyen, Beck A., Sinai C., Czech T., Dorfer C., Goumnerova L., Lavarino C., Carcaboso A. M., Mora J., Mylvaganam R., Luo C. C., Peyrl A., Popovic M., Azizi A., Batchelor T. T., Frosch M. P., Martinez-Lage M., Kieran M. W., Bandopadhayay P., Beroukhim R., Fritsch G., Getz G., Rozenblatt-Rosen O., Wucherpfennig K. W., Louis D. N., Monje M., Slavc I., Ligon K. L., Golub T. R., Regev A., Bernstein B. E. & Suva M. L. (2018), Science. 360, 6386, p. 331-335
  • The Tumor Necrosis Factor Family: Family Conventions and Private Idiosyncrasies

  • Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies

    Authors: Roncato F., Rruga F., Porcu E., Casarin E., Ronca R., Maccarinelli F., Realdon N., Basso G., Alon R., Viola G. & Morpurgo M. (2018), Nature Communications. 9, 1, 4070
  • A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen

    Authors: Amon R., Grant O. C., Ben-Arye S. L., Makeneni S., Nivedha A. K., Marshanski T., Norn C., Yu H., Glushka J. N., Fleishman S. J., Chen X., Woods R. J. & Padler-Karavani V. (2018), Scientific Reports. 8, 10786
  • Mutated MITF-E87R in Melanoma Enhances Tumor Progression via S100A4

    Authors: Nordlinger A., Dror S., Elkahloun A., Del Rio J., Stubbs E., Golan T., Malcov H., Pricket T. D., Cronin J. C., Parikh S., Labes S., Thomas L., Yankovitz G., Tabach Y., Levy C., Samuels Y. & Khaled M. (2018), Journal of Investigative Dermatology. 138, 10, p. 2216-2223
  • Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer

    Authors: Shin S., Müller A., Verma N., Lev S. & Nguyen L. K. (2018), PLoS Computational Biology. 14, 6, 1006192
  • A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

    Authors: Griveau A., Seano G., Shelton S. J., Kupp R., Jahangiri A., Obernier K., Krishnan S., Lindberg O. R., Yuen T. J., Tien A., Sabo J. K., Wang N., Chen I., Kloepper J., Larrouquere L., Ghosh M., Tirosh I., Huillard E., Alvarez-Buylla A., Oldham M. C., Persson A. I., Weiss W. A., Batchelor T. T., Stemmer-Rachamimov A., Suva M. L., Phillips J. J., Aghi M. K., Mehta S., Jain R. K. & Rowitch D. H. (2018), Cancer Cell. 33, 5, p. 874-889
  • Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide

    Authors: Tamura T., Ueda T., Goto T., Tsukidate T., Shapira Y., Nishikawa Y., Fujisawa A. & Hamachi I. (2018), Nature Communications. 9, 1870
  • Direct Real-Time Monitoring of Prodrug Activation by Chemiluminescence

    Authors: Gnaim S., Scomparin A., Das S., Blau R., Satchi-Fainaro R. & Shabat D. (2018), Angewandte Chemie - International Edition. 57, 29, p. 9033-9037
  • Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents

    Authors: Geller L. T. & Straussman R. (2018), Molecular and Cellular Oncology. 5, 1, e1405139
  • Induction of Nitric-Oxide Metabolism in Enterocytes Alleviates Colitis and Inflammation-Associated Colon Cancer

    Authors: Stettner N., Rosen C., Bernshtein B., Gur-Cohen S., Frug J., Silberman A., Sarver A., Carmel-Neiderman N. N., Eilam R., Biton I., Pevsner-Fischer M., Zmora N., Brandis A., Halpern K. B., Mazkereth R., di Bernardo D., Brunetti-Pierri N., Premkumar M. H., Dank G., Nagamani S. C. S., Jung S., Harmelin A. & Erez A. (2018), Cell Reports. 23, 7, p. 1962-1976
  • Expansion and Antitumor Cytotoxicity of T-Cells Are Augmented by Substrate-Bound CCL21 and Intercellular Adhesion Molecule 1

    Authors: Adutler-Lieber S., Friedman N. & Geiger B. (2018), Frontiers in Immunology. 9, 1303
  • Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases

  • International conference on Cell Death in Cancer and Toxicology 2018 (CDCT-2018)

    Authors: Ansari K. M., Arany P. R., Arama E., Larisch S., Birge R. B. & Chandra D. (2018), Cell Communication and Signaling. 16, 34
  • Clinical Proteomics of Breast Cancer Reveals a Novel Layer of Breast Cancer Classification

    Authors: Yanovich G., Agmon H., Harel M., Sonnenblick A., Peretz T. & Geiger T. (2018), Cancer research (Chicago, Ill.). 78, 20, p. 6001-6010
  • Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer

    Authors: Shee K., Yang W., Hinds J. W., Hampsch R. A., Varn F. S., Traphagen N. A., Patel K., Cheng C., Jenkins N. P., Kettenbach A. N., Demidenko E., Owens P., Faber A. C., Golub T. R., Straussman R. & Miller T. W. (2018), Journal of Experimental Medicine. 215, 3, p. 895-910
  • Quiescin sulfhydryl oxidase 1 (QSOX1) glycosite mutation perturbs secretion but not Golgi localization

    Authors: Horowitz B., Javitt G., Ilani T., Gat Y., Morgenstern D., Bard F. A. & Fass D. (2018), Glycobiology. 28, 8, p. 580-591
  • Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries

    Authors: Giladi A. & Amit I. (2018), Cell. 172, 1-2, p. 14-21
  • The Proteome of Prostate Cancer Bone Metastasis Reveals Heterogeneity with Prognostic Implications

    Authors: Iglesias-Gato D., Thysell E., Tyanova S., Crnalic S., Santos A., Lima T. S., Geiger T., Cox J., Widmark A., Bergh A., Mann M., Flores-Morales A. & Wikström P. (2018), Clinical Cancer Research. 24, 21, p. 5433-5444
  • Senescence and Telomere Homeostasis Might Be Involved in Placenta Percreta-Preliminary Investigation

    Authors: Geffen K. T., Gal H., Vainer I., Markovitch O., Amiel A., Krizhanovsky V. & Biron-Shental T. (2018), Reproductive Sciences. 25, 8, p. 1254-1260
  • NKp46 Receptor-Mediated Interferon-gamma Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis

    Authors: Glasner A., Levi A., Enk J., Isaacson B., Viukov S., Orlanski S., Scope A., Neuman T., Enk C. D., Hanna J. H., Sexl V., Jonjic S., Seliger B., Zitvogel L. & Mandelboim O. (2018), Immunity. 48, 1, p. 107-+
  • Analysis of enzymatic activity of matrix metalloproteinase (MMP) by collagen zymography in Melanoma

  • Mining Plants for Bacterial Quorum Sensing Modulators

    Authors: David S., Mandabi A., Uzi S., Aharoni A. & Meijler M. M. (2018), ACS Chemical Biology. 13, 1, p. 247-252
  • SUSHI: Sparsity-Based Ultrasound Super-Resolution Hemodynamic Imaging

    Authors: Bar-Zion A., Solomon O., Tremblay-Darveau C., Adam D. & Eldar Y. C. (2018), IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 65, 12, p. 2365-2380
  • Randomized Trial of Partial Gland Ablation with Vascular Targeted Phototherapy versus Active Surveillance for Low Risk Prostate Cancer: Extended Followup and Analyses of Effectiveness

    Authors: Gill I. S., Azzouzi A. R., Emberton M., Coleman J. A. & Scherz A. (2018), Journal of Urology. 200, 4, p. 786-793
  • Fresh water, marine and terrestrial cyanobacteria display distinct allergen characteristics

    Authors: Lang-Yona N., Kunert A. T., Vogel L., Kampf C. J., Bellinghausen I., Saloga J., Schink A., Ziegler K., Lucas K., Schuppan D., Poeschl U., Weber B. & Froelich-Nowoisky J. (2018), Science of the Total Environment. 612, p. 767-774
  • The tolerogenic peptide hCDR1 immunomodulates cytokine and regulatory molecule gene expression in blood mononuclear cells of primary Sjogren's syndrome patients

    Authors: Sthoeger Z., Sharabi A., Asher I., Zinger H., Segal R., Shearer G., Elkayam O. & Mozes E. (2018), Clinical Immunology. 192, p. 85-91
  • Ex-vivo organ culture as potential prioritization tool for breast cancer targeted therapy

    Authors: Grinshpun A., Gavert N., Granit R. Z., Masuri H., Ben-Porath I., Breuer S., Zick A., Rosenberg S., Maoz M., Granit A., Pikarsky E., Straussman R., Peretz T. & Sonnenblick A. (2018), Cancer Biology and Therapy. 19, 8, p. 645-648
  • Harnessing synthetic lethality to predict the response to cancer treatment

    Authors: Lee J. S., Das A., Jerby-Arnon L., Arafeh R., Auslander N., Davidson M., McGarry L., James D., Amzallag A., Park S. G., Cheng K., Robinson W., Atias D., Stossel C., Buzhor E., Stein G., Waterfall J. J., Meltzer P. S., Golan T., Hannenhalli S., Gottlieb E., Benes C. H., Samuels Y., Shanks E. & Ruppin E. (2018), Nature Communications. 9, 2546
  • Cell-cell adhesion: linking Wnt/β-catenin signaling with partial EMT and stemness traits in tumorigenesis

    Authors: Basu S., Cheriyamundath S. & Ben-Ze'ev A. (2018), F1000Research. 7
  • New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins

    Authors: Golovenko D., Bräuning B., Vyas P., Haran T. E., Rozenberg H. & Shakked Z. (2018), Structure. 26, 9, p. 1237-1250
  • Systemic antitumor immunity by PD-1/PD-L1 inhibition is potentiated by vascular-targeted photodynamic therapy of primary tumors

    Authors: O'Shaughnessy M. J., Murray K. S., La Rosa S. P., Budhu S., Merghoub T., Somma A., Monette S., Kim K., Corradi R. B., Scherz A. & Coleman J. A. (2018), Clinical Cancer Research. 24, 3, p. 592-599
  • Phagocyte-extracellular matrix crosstalk empowers tumor development and dissemination

    Authors: Varol C. & Sagi I. (2018), The FEBS journal. 285, 4, p. 734-751
  • Prediction of acute myeloid leukaemia risk in healthy individuals

    Authors: Abelson S., Collord G., Ng S. W. K., Weissbrod O., Mendelson Cohen N., Niemeyer E., Barda N., Zuzarte P. C., Heisler L., Sundaravadanam Y., Luben R., Hayat S., Wang T. T., Zhao Z., Cirlan I., Pugh T. J., Soave D., Ng K., Latimer C., Hardy C., Raine K., Jones D., Hoult D., Britten A., McPherson J. D., Johansson M., Mbabaali F., Eagles J., Miller J. K., Pasternack D., Timms L., Krzyzanowski P., Awadalla P., Costa R., Segal E., Bratman S. V., Beer P., Behjati S., Martincorena I., Wang J. C. Y., Bowles K. M., Quirós J. R., Karakatsani A., La Vecchia C., Trichopoulou A., Salamanca-Fernández E., Huerta J. M., Barricarte A., Travis R. C., Tumino R., Masala G., Boeing H., Panico S., Kaaks R., Krämer A., Sieri S., Riboli E., Vineis P., Foll M., McKay J., Polidoro S., Sala N., Khaw K., Vermeulen R., Campbell P. J., Papaemmanuil E., Minden M. D., Tanay A., Balicer R. D., Wareham N. J., Gerstung M., Dick J. E., Brennan P., Vassiliou G. S. & Shlush L. I. (2018), Nature. 559, 7714, p. 400-404
  • CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma

    Authors: Alon M., Arafeh R., Lee J. S., Madan S., Kalaora S., Nagler A., Abgarian T., Greenberg P., Ruppin E. & Samuels Y. (2018), Oncotarget. 9, 58, p. 31264-31277
  • Refinement of the endogenous epitope tagging technology allows the identification of a novel NRAS binding partner in melanoma

    Authors: Alon M., Emmanuel R., Qutob N., Bakhman A., Peshti V., Brodezki A., Bassan D., Kosloff M. & Samuels Y. (2018), Pigment Cell and Melanoma Research. 31, 5, p. 641-648
  • Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer

    Authors: Puram S. V., Parikh A. S. & Tirosh I. (2018), Molecular & cellular oncology. 5, 3, e1448244
  • Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016

    Authors: Al Malki M. M., Jones R., Ma Q., Lee D., Reisner Y., Miller J. S., Lang P., Hongeng S., Hari P., Strober S., Yu J., Maziarz R., Mavilio D., Roy D., Bonini C., Champlin R. E., Fuchs E. J. & Ciurea S. O. (2018), Biology of Blood and Marrow Transplantation. 24, 5, p. 895-908
  • Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

    Authors: Lee J. S., Adler L., Karathia H., Carmel N., Rabinovich S., Auslander N., Keshet R., Stettner N., Silberman A., Agemy L., Helbling D., Eilam R., Sun Q., Brandis A., Malitsky S., Itkin M., Weiss H., Pinto S., Kalaora S., Levy R., Barnea E., Admon A., Dimmock D., Stern-Ginossar N., Scherz A., Nagamani S. C. S., Unda M., Wilson D. M., Elhasid R., Carracedo A., Samuels Y., Hannenhalli S., Ruppin E. & Erez A. (2018), Cell. 174, 6, p. 1559-1570
  • Dual role of E-cadherin in the regulation of invasive collective migration of mammary carcinoma cells

    Authors: Elisha Y., Kalchenko V., Kuznetsov Y. & Geiger B. (2018), Scientific Reports. 8, 4986
  • PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma

    Authors: Ghannam-Shahbari D., Jacob E., Kakun R. R., Wasserman T., Korsensky L., Sternfeld O., Kagan J., Bublik D. R., Aviel-Ronen S., Levanon K., Sabo E., Larisch S., Oren M., Hershkovitz D. & Perets R. (2018), Oncogene. 37, 17, p. 2213-2224
  • An exploratory study of adolescent response to fluoxetine using psychological and biological predictors

    Authors: Zohar A. H., Eilat T., Amitai M., Taler M., Bari R., Chen A., Apter A., Weizman A. & Fennig S. (2018), PeerJ. 6, 4240
  • Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity

  • A sorafenib-sparing effect in the treatment of thyroid carcinoma cells attained by co-treatment with a novel isoflavone derivative and 1,25 dihydroxyvitamin D3

    Authors: Izkhakov E., Sharon O., Knoll E., Aizic A., Fliss D. M., Kohen F., Stern N. & Somjen D. (2018), Journal of Steroid Biochemistry and Molecular Biology. 182, p. 81-86
  • Molecular mechanisms underlying the role of galectin-8 as a regulator of cancer growth and metastasis

    Authors: Vinik Y., Shatz-Azoulay H. & Zick Y. (2018),
  • Nonredundant, highly connected microRNAs control functionality in breast cancer networks

    Authors: De Anda-Jáuregui G., Espinal-Enríquez J., Drago-García D. & Hernández-Lemus E. (2018), International Journal of Genomics. 2018, 9585383
  • Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

    Authors: Kalaora S., Wolf Y., Feferman T., Barnea E., Greenstein E., Reshef D., Tirosh I., Reuben A., Patkar S., Levy R., Quinkhardt J., Omokoko T., Qutob N., Golani O., Zhang J., Mao X., Song X., Bernatchez C., Haymaker C., Forget M., Creasy C., Greenberg P., Carter B. W., Cooper Z. A., Rosenberg S. A., Lotem M., Sahin U., Shakhar G., Ruppin E., Wargo J. A., Friedman N., Admon A. & Samuels Y. (2018), Cancer Discovery. 8, 11, p. 1366-1375
  • A Combination of Approved Antibodies Overcomes Resistance of Lung Cancer to Osimertinib by Blocking Bypass Pathways

    Authors: Romaniello D., Mazzeo L., Mancini M., Marrocco I., Noronha A., Kreitman M., Srivastava S., Ghosh S., Lindzen M., Salame T. M., Onn A., Bar J. & Yarden Y. (2018), Clinical Cancer Research. 24, 22, p. 5610-5621
  • Rewiring urea cycle metabolism in cancer to support anabolism

    Authors: Keshet R., Szlosarek P., Carracedo A. & Erez A. (2018), Nature Reviews Cancer. 18, 10, p. 634-645
  • IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer

    Authors: Zhang Y., Wester L., He J., Geiger T., Moerkens M., Siddappa R., Helmijr J. A., Timmermans M. M., Look M. P., van Deurzen C. H. M., Martens J. W. M., Pont C., de Graauw M., Danen E. H. J., Berns E. M. J. J., Meerman J. H. N., Jansen M. P. H. M. & van de Water B. (2018), Oncogene. 37, 14, p. 1869-1884
  • A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation

    Authors: Kotler E., Shani O., Goldfeld G., Lotan-Pompan M., Tarcic O., Gershoni A., Hopf T. A., Marks D. S., Oren M. & Segal E. (2018), Molecular Cell. 71, 1, p. 178-190.e8
  • Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

    Authors: Gutjahr J. C., Szenes E., Tschech L., Asslaber D., Schlederer M., Roos S., Yu X., Girbl T., Sternberg C., Egle A., Aberger F., Alon R., Kenner L., Greil R., Orian-Rousseau V. & Hartmann T. N. (2018), Blood. 131, 12, p. 1337-1349
  • A biological-computational human cell lineage discovery platform based on duplex molecular inversion probes

    Authors: Tao L., Raz O., Marx Z., Biezuner T., Amir S., Milo L., Adar R., Onn A., Chapal-Ilani N., Berman V., Levy R., Oron B., Halaban R. & Shapiro E. (2018), BioRxiv.
  • Differentiation Between Vasogenic Edema and Infiltrative Tumor in Patients With High-Grade Gliomas Using Texture Patch-Based Analysis

    Authors: Artzi M., Liberman G., Blumenthal D. T., Aizenstein O., Bokstein F. & Ben Bashat D. (2018), Jmri-Journal Of Magnetic Resonance Imaging. 48, 3, p. 729-736
  • Loss of C/EBP-beta LIP drives cisplatin resistance in malignant pleural mesothelioma

    Authors: Kopecka J., Salaroglio I. C., Righi L., Libener R., Orecchia S., Grosso F., Milosevic V., Ananthanarayanan P., Ricci L., Capelletto E., Pradotto M., Napoli F., Di Maio M., Novello S., Rubinstein M., Scagliotti G. V. & Riganti C. (2018), Lung Cancer. 120, p. 34-45
  • p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence

    Authors: Sagiv A., Bar-Shai A., Levi N., Hatzav M., Zada L., Ovadya Y., Roitman L., Manella G., Regev O., Majewska J., Vadai E., Eilam R., Feigelson S. W., Tsoory M., Tauc M., Alon R. & Krizhanovsky V. (2018), Cell Reports. 22, 13, p. 3468-3479
  • Androgen deprivation therapy potentiates the efficacy of vascular targeted photodynamic therapy of prostate cancer xenografts

    Authors: Kim K., Watson P. A., Lebdai S., Jebiwott S., Somma A. J., Rosa S. L., Mehta D., Murray K. S., Lilja H., Ulmert D., Monette S., Scherz A. & Coleman J. A. (2018), Clinical Cancer Research. 24, 10, p. 2408-2416
  • Functional characterization of the p53 "mutome"

    Authors: Kotler E., Segal E. & Oren M. (2018), Molecular & cellular oncology. 5, 6, 1511207
  • A modular platform for targeted RNAi therapeutics

    Authors: Kedmi R., Veiga N., Ramishetti S., Goldsmith M., Rosenblum D., Dammes N., Hazan-Halevy I., Nahary L., Leviatan-Ben-Arye S., Harlev M., Behlke M., Benhar I., Lieberman J. & Peer D. (2018), Nature Nanotechnology. 13, p. 214-219
  • Efficient Therapeutic Protein Expression Using Retroviral Replicating Vector with 2A Peptide in Cancer Models

    Authors: Hofacre A., Yagiz K., Mendoza D., Lopez Espinoza F., Munday A. W., Burrascano C., Singer O., Gruber H. E., Jolly D. J. & Lin A. H. (2018), Human Gene Therapy. 29, 4, p. 437-451
  • A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells

    Authors: Koifman G., Shetzer Y., Eizenberger S., Solomon H., Rotkopf R., Molchadsky A., Lonetto G., Goldfinger N. & Rotter V. (2018), Cancer Research. 78, 20, p. 5833-5847
  • LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state

    Authors: Furth N., Pateras I. S., Rotkopf R., Vlachou V., Rivkin I., Schmitt I., Bakaev D., Gershoni A., Ainbinder E., Leshkowitz D., Johnson R. L., Gorgoulis V. G., Oren M. & Aylon Y. (2018), Life science alliance. 1, 5, 201800171
  • ICAMs Are Not Obligatory for Functional Immune Synapses between Naive CD4 T Cells and Lymph Node DCs

    Authors: Feigelson S. W., Solomon A., Biram A., Hatzav M., Lichtenstein M., Regev O., Kozlovski S., Varol D., Curato C., Leshkowitz D., Jung S., Shulman Z. & Alon R. (2018), Cell Reports. 22, 4, p. 849-859
  • Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition

    Authors: Schneidman-Duhovny D., Khuri N., Dong G. Q., Winter M. B., Shifrut E., Friedman N., Craik C. S., Pratt K. P., Paz P., Aswad F. & Sali A. (2018), PLoS ONE. 13, 11, 0206654
  • Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion

    Authors: Gorelick-Ashkenazi A., Weiss R., Sapozhnikov L., Florentin A., Tarayrah-Ibraheim L., Dweik D., Yacobi-Sharon K. & Arama E. (2018), Nature Communications. 9, 2806
  • Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models

    Authors: Minzel W., Venkatachalam A., Fink A., Hung E., Brachya G., Burstain I., Shaham M., Rivlin A., Omer I., Zinger A., Elias S., Winter E., Erdman P. E., Sullivan R. W., Fung L., Mercurio F., Li D., Vacca J., Kaushansky N., Shlush L., Oren M., Levine R., Pikarsky E., Snir-Alkalay I. & Ben-Neriah Y. (2018), Cell. 175, 1, p. 171-185
  • Increasing intratumor C/EBP- LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer

    Authors: Salaroglio I. C., Gazzano E., Abdullrahman A., Mungo E., Castella B., Abd-elrahman G. E. F. A., Massaia M., Donadelli M., Rubinstein M., Riganti C. & Kopecka J. (2018), Journal Of Experimental & Clinical Cancer Research. 37, 286
  • The anti-inflammatory IFITM genes ameliorate colitis and partially protect from tumorigenesis by changing immunity and microbiota

    Authors: Alteber Z., Sharbi-Yunger A., Pevsner-Fischer M., Blat D., Roitman L., Tzehoval E., Elinav E. & Eisenbach L. (2018), Immunology and Cell Biology. 96, 3, p. 284-297
  • The immune system profoundly restricts intratumor genetic heterogeneity

    Authors: Milo I., Bedora-Faure M., Garcia Z., Thibaut R., Perie L., Shakhar G., Deriano L. & Bousso P. (2018), Science immunology. 3, 29, 1435
  • Delivery of ROS Generating Anthraquinones Using Reduction-Responsive Peptide-Based Nanoparticles

    Authors: Richard P. U., Craciun I., Gaitzsch J., Weiner L. & Palivan C. G. (2018), Helvetica Chimica Acta. 101, 7, 1800064
  • Helminths-based bi-functional molecule, tuftsin-phosphorylcholine (TPC), ameliorates an established murine arthritis

    Authors: Blank M., Bashi T., Lachnish J., Ben-Ami-Shor D., Shovman O., Fridkin M., Eisenstein M., Volkov A., Barshack I. & Shoenfeld Y. (2018), PLoS ONE. 13, 8, 0200615
  • MRI radiomics analysis of molecular alterations in low-grade gliomas

    Authors: Shofty B., Artzi M., Ben Bashat D., Liberman G., Haim O., Kashanian A., Bokstein F., Blumenthal D. T., Ram Z. & Shahar T. (2018), Computer-Assisted Radiology and Surgery. 13, 4, p. 563-571
  • An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors

    Authors: Mancini M., Gal H., Gaborit N., Mazzeo L., Romaniello D., Salame T. M., Lindzen M., Mahlknecht G., Enuka Y., Burton D. G. A., Roth L., Noronha A., Marrocco I., Adreka D., Altstadter R. E., Bousquet E., Downward J., Maraver A., Krizhanovsky V. & Yarden Y. (2018), EMBO Molecular Medicine. 10, 2, p. 294-308
  • Soluble SLAMF6 Receptor Induces Strong CD8 + T-cell Effector Function and Improves Anti-Melanoma Activity In Vivo

    Authors: Eisenberg G., Engelstein R., Geiger-Maor A., Hajaj E., Merims S., Frankenburg S., Uzana R., Rutenberg A., Machlenkin A., Frei G., Peretz T. & Lotem M. (2018), Cancer Immunology Research. 6, 2, p. 127-138
  • Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer

    Authors: Zupancic E., Curato C., Kim J., Yeini E., Porat Z., Viana A. S., Globerson-Levin A., Waks T., Eshhar Z., Moreira J. N., Satchi-Fainaro R., Eisenbach L., Jung S. & Florindo H. F. (2018), Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 3, p. 835-847
  • A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

    Authors: Bahr C., von Paleske L., Slu V. V. U., Emeseiro S. R., Takayama N., Ng S. W., Murison A., Langenfeld K., Petretich M., Scognamiglio R., Zeisberger P., Benk A. S., Amit I., Zandstra P. W., Lupien M., Dick J. E., Trumpp A. & Spitz F. (2018), Nature. 553, 7689, p. 515-+
  • The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression

    Authors: Basu S., Gavert N., Brabletz T. & Ben-Ze'ev A. (2018), Cancer Letters. 424, p. 9-18
  • Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

    Authors: Martin D., Degese M. S., Vitale-Cross L., Iglesias-Bartolome R., Valera J. L. C., Wang Z., Feng X., Yeerna H., Vadmal V., Moroishi T., Thorne R. F., Zaida M., Siegele B., Cheong S. C., Molinolo A. A., Samuels Y., Tamayo P., Guan K. L., Lippman S. M., Lyons J. G. & Gutkind J. S. (2018), Nature Communications. 9, 2372
  • Optimized dendritic cell vaccination induces potent CD8 T cell responses and anti-tumor effects in transgenic mouse melanoma models

    Authors: Grees M., Sharbi-Yunger A., Evangelou C., Baumann D., Cafri G., Tzehoval E., Eichmueller S. B., Offringa R., Utikal J., Eisenbach L. & Umansky V. (2018), OncoImmunology. 7, 7, 1445457
  • A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging

    Authors: Keren L., Bosse M., Marquez D., Angoshtari R., Jain S., Varma S., Yang S., Kurian A., Van Valen D., West R., Bendall S. C. & Angelo M. (2018), Cell. 174, 6, p. 1373-1387
  • TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma

    Authors: Jethwa A., Slabicki M., Huellein J., Jentzsch M., Dala V., Rabe S., Wagner L., Walther T., Klapper W., Bohnenberger H., Rettel M., Lu J., Smits A. H., Stein F., Savitski M. M., Huber W., Aylon Y., Oren M. & Zenz T. (2018), Blood. 131, 25, p. 2789-2802
  • Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins

    Authors: Winer H., Fraiberg M., Abada A., Dadosh T., Tamim-Yecheskel B. & Elazar Z. (2018), Nature Communications. 9, 3744
  • Arginine and the metabolic regulation of nitric oxide synthesis in cancer

    Authors: Keshet R. & Erez A. (2018), Disease Models & Mechanisms. 11, 8, dmm033332
  • Intratumor heterogeneity in epigenetic patterns

    Authors: Assenov Y., Brocks D. & Gerhaeuser C. (2018), Seminars in Cancer Biology. 51, p. 12-21
  • The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition

    Authors: Kahlon S., Shreibman D., Unger T., Ben-Yehuda D. & Elias S. (2018),
  • A phase I-II clinical trial of the anti-CD74 monoclonal antibody milatuzumab in frail patients with refractory chronic lymphocytic leukaemia: A patient based approach

    Authors: Haran M., Mirkin V., Braester A., Harpaz N., Shevetz O., Shtreiter M., Greenberg S., Mordich O., Amram O., Binsky-Ehrenreich I., Marom A., Shachar I., Herishanu Y., Ruchlemer R., Berrebi A., Valinsky L., Shtalrid M. & Shvidel L. (2018),
  • LPS-mediated cell surface expression of CD74 promotes the proliferation of B cells in response to MIF

    Authors: Klasen C., Ziehm T., Huber M., Asare Y., Kapurniotu A., Shachar I., Bernhagen J. & El Bounkari O. (2018), Cellular Signalling. 46, p. 32-42
  • The HTLV-1 gp21 fusion peptide inhibits antigen specific T-cell activation in-vitro and in mice

    Authors: Rotem E., Faingold O., Charni M., Klug Y. A., Harari D., Shmuel-Galia L., Nudelman A., Rotter V. & Shai Y. (2018), PLoS Pathogens. 14, 5, e1007044
  • Laplacian pyramid based data fusion for high resolution dynamic MRI

    Authors: Pollack-Zuckerman L., Weizman L., Eldar Y. C., Ben Bashat D., Arzi M. & Irani M. (2018),
  • Brain investigations of rodent disease models by chemical exchange saturation transfer at 21.1T

    Authors: Roussel T., Rosenberg J. T., Grant S. C. & Frydman L. (2018), NMR in Biomedicine. 31, 11, e3995
  • SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors

    Authors: Roth L., Srivastava S., Lindzen M., Sas-Chen A., Sheffer M., Lauriola M., Enuka Y., Noronha A., Mancini M., Lavi S., Tarcic G., Pines G., Nevo N., Heyman O., Ziv T., Rueda O. M., Gnocchi D., Pikarski E., Admon A., Caldas C. & Yarden Y. (2018), Science Signaling. 11, 515, 0949
  • Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner

    Authors: Charni-Natan M., Solomon H., Molchadsky A., Jacob-Berger A., Goldfinger N. & Rotter V. (2018), Cell Death and Disease. 9, 647
  • RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

    Authors: Qutob N., Masuho I., Alon M., Emmanuel R., Cohen I., Di Pizio A., Madore J., Elkahloun A., Ziv T., Levy R., Gartner J. J., Hill V. K., Lin J. C., Hevroni Y., Greenberg P., Brodezki A., Rosenberg S. A., Kosloff M., Hayward N. K., Admon A., Niv M. Y., Scolyer R. A., Martemyanov K. A. & Samuels Y. (2018), Scientific Reports. 8, 653
  • MiRNA-513a-5p inhibits progesterone receptor expression and constitutes a risk factor for breast cancer: The hOrmone and Diet in the ETiology of breast cancer prospective study

    Authors: Muti P., Donzelli S., Sacconi A., Hossain A., Ganci F., Frixa T., Sieri S., Krogh V., Berrino F., Biagioni F., Strano S., Beyene J., Yarden Y. & Blandino G. (2018), Carcinogenesis. 39, 2, p. 98-108
  • Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

    Authors: Galanos P., Pappas G., Polyzos A., Kotsinas A., Svolaki I., Giakoumakis N. N., Glytsou C., Pateras I. S., Swain U., Souliotis V. L., Georgakilas A. G., Geacintov N., Scorrano L., Lukas C., Lukas J., Livneh Z., Lygerou Z., Chowdhury D., Sorensen C. S., Bartek J. & Gorgoulis V. G. (2018), Genome Biology. 19, 1, 37
  • CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia

    Authors: Lewinsky H., Barak A. F., Huber V., Kramer M. P., Radomir L., Sever L., Orr I., Mirkin V., Dezorella N., Shapiro M., Cohen Y., Shvidel L., Seiffert M., Herishanu Y., Becker-Herman S. & Shachar I. (2018), Journal of Clinical Investigation. 128, 12, p. 5465-5478
  • Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features

    Authors: Arandkar S., Furth N., Elisha Y., Belugali Nataraj N., van der Kuip H., Yarden Y., Aulitzky W., Ulitsky I., Geiger B. & Oren M. (2018), Proceedings Of The National Academy Of Sciences Of The United States Of America-Biological Sciences. 115, 25, p. 6410-6415
  • WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice

    Authors: Neuschmelting V., Kim K., Malekzadeh-Najafabadi J., Jebiwott S., Prakash J., Scherz A., Coleman J. A., Kircher M. F. & Ntziachristos V. (2018), Theranostics. 8, 3, p. 723-734
  • Cancer research in the era of immunogenomics

    Authors: Wolf Y. & Samuels Y. (2018), ESMO Open. 3, 7, e000475
  • The PTPROt tyrosine phosphatase functions as an obligate haploinsufficient tumor suppressor in vivo in B-cell chronic lymphocytic leukemia

    Authors: Wakim J., Arman E., Becker Herman S., Kramer M. P., Bakos E., Shachar I. & Elson A. (2017), Oncogene. 36, 26, p. 3686-3694
  • Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis

    Authors: Edison N., Curtz Y., Paland N., Mamriev D., Chorubczyk N., Haviv-Reingewertz T., Kfir N., Morgenstern D., Kupervaser M., Kagan J., Kim H. T. & Larisch S. (2017), Cell Reports. 21, 2, p. 442-454
  • Dynamic proteomics reveals bimodal protein dynamics of cancer cells in response to HSP90 inhibitor

    Authors: Zimmer A., Amar Farkash F. S., Danon T. & Alon U. (2017), BMC Systems Biology. 11, 1, 33
  • Augmented expression of RUNX1 deregulates the global gene expression of U87 glioblastoma multiforme cells and inhibits tumor growth in mice

    Authors: Bogoch Y., Friedlander-Malik G., Lupu L., Bondar E., Zohar N., Langier S., Ram Z., Nachmany I., Klausner J. M. & Pencovich N. (2017), Tumor Biology. 39, 4
  • Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

    Authors: Geller L. T., Barzily-Rokni M., Danino T., Jonas O. H., Shental N., Nejman D., Gavert N., Zwang Y., Cooper Z. A., Shee K., Thaiss C. A., Reuben A., Livny J., Avraham R., Frederick D. T., Ligorio M., Chatman K., Johnston S. E., Mosher C. M., Brandis A., Fuks G., Gurbatri C., Gopalakrishnan V., Kim M., Hurd M. W., Katz M., Fleming J., Maitra A., Smith D. A., Skalak M., Bu J., Michaud M., Trauger S. A., Barshack I., Golan T., Sandbank J., Flaherty K. T., Mandinova A., Garrett W. S., Thayer S. P., Ferrone C. R., Huttenhower C., Bhatia S. N., Gevers D., Wargo J. A., Golub T. R. & Straussman R. (2017), Science. 357, 6356, p. 1156-1160
  • Runx3 in Immunity, Inflammation and Cancer

  • Diverse p53/DNA binding modes expand the repertoire of p53 response elements

    Authors: Vyas P., Beno I., Xi Z., Stein Y., Golovenko D., Kessler N., Rotter V., Shakked Z. & Haran T. E. (2017), Proceedings of the National Academy of Sciences of the United States of America. 114, 40, p. 10624-10629
  • Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation

    Authors: Wolf Y., Shemer A., Polonsky M., Gross-Vered M., Mildner A., Yona S., David E., Kim K., Goldmann T., Amit I., Heikenwalder M., Nedospasov S., Prinz M., Friedman N. & Jung S. (2017), Journal of Experimental Medicine. 214, 4, p. 905-917
  • A point mutation in the extracellular domain of L1 blocks its capacity to confer metastasis in colon cancer cells via CD10

    Authors: Haase G., Gavert N., Brabletz T. & Ben-Ze'ev A. (2017), Oncogene. 36, 11, p. 1597-1606
  • Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression

    Authors: Glasner A., Isaacson B., Viukov S., Neuman T., Friedman N., Mandelboim M., Sexl V., Hanna J. H. & Mandelboim O. (2017), Scientific Reports. 7, 13090
  • Real Time Laser Speckle Imaging Monitoring Vascular Targeted Photodynamic Therapy

  • A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

    Authors: Boege Y., Malehmir M., Healy M. E., Bettermann K., Lorentzen A., Vucur M., Ahuja A. K., Bohm F., Mertens J. C., Shimizu Y., Frick L., Remouchamps C., Mutreja K., Kaehne T., Sundaravinayagam D., Wolf M. J., Rehrauer H., Koppe C., Speicher T., Padrissa-Altes S., Maire R., Schattenberg J. R. M., Jeong J., Liu L., Zwirner S., Boger R., Hueser N., Davis R. J., Mullhaupt B., Moch H., Schulze-Bergkamen H., Clavien P., Werner S., Borsig L., Luther S. A., Jost P. J., Weinlich R., Unger K., Behrens A., Hillert L., Dillon C., Di Virgilio V. M., Wallach D., Dejardin E., Zender L., Naumann M., Walczak H., Green D. R., Lopes M., Lavrik I., Luedde T., Heikenwalder M. & Weber A. (2017), Cancer Cell. 32, 3, p. 342-359.e10
  • p53 is essential for DNA methylation homeostasis in naive embryonic stem cells, and its loss promotes clonal heterogeneity

    Authors: Tovy A., Spiro A., McCarthy R., Shipony Z., Aylon Y., Allton K., Ainbinder E., Furth N., Tanay A., Barton M. & Oren M. (2017), GENES & DEVELOPMENT. 31, 10, p. 959-972
  • Light-Stimulated Generation of Free Radicals by Quinones-Chelators

    Authors: Markova I. D., Polyakov N. E., Selyutina O. Y., Fedenok L. G., Fedotov K. Y., Slepneva I. A., Leshina T. V., Pokrovsky A. G., Vasilieva N. V. & Weiner L. M. (2017), Zeitschrift Fur Physikalische Chemie-International Journal Of Research In Physical Chemistry & Chemical Physics. 231, 2, p. 369-389
  • CD84 mediates CLL-microenvironment interactions

    Authors: Marom A., Barak A. F., Kramer M. P., Lewinsky H., Binsky-Ehrenreich I., Cohen S., Tsitsou-Kampeli A., Kalchenko V. (., Kuznetsov Y., Mirkin V., Dezorella N., Shapiro M., Schwartzberg P. L., Cohen Y., Shvidel L., Haran M., Becker Herman S., Herishanu Y. & Shachar I. (2017), Oncogene. 36, 5, p. 628-638
  • Contrast enhanced ultrasound imaging can predict vascular-targeted photodynamic therapy induced tumor necrosis in small animals

    Authors: Comelis F. H., Kim K., Durack J. C., Jebiwott S., Scherz A., Srimathveeravalli G. & Coleman J. A. (2017), Photodiagnosis and Photodynamic Therapy. 20, p. 165-168
  • Non-canonical NF kappa B mutations reinforce pro-survival TNF response in multiple myeloma through an autoregulatory RelB: p50 NF kappa B pathway

    Authors: Roy P., Mukherjee T., Chatterjee B., Vijayaragavan B., Banoth B. & Basak S. (2017), Oncogene. 36, 10, p. 1417-1429
  • Matrix Mechanosensing: From Scaling Concepts in 'Omics Data to Mechanisms in the Nucleus, Regeneration, and Cancer

    Authors: Discher D. E., Smith L., Cho S., Colasurdo M., Garcia A. J. & Safran S. (2017), Annual Review of Biophysics. 46, p. 295-315
  • The short and the long: non-coding RNAs and growth factors in cancer progression

    Authors: Sas-Chen A., Srivastava S. & Yarden Y. (2017), Biochemical Society Transactions. 45, 1, p. 51-64
  • Biological and clinical consequences of NPM1 mutations in AML

    Authors: Heath E. M., Chan S. M., Minden M. D., Murphy T., Shlush L. I. & Schimmer A. D. (2017), Leukemia. 31, 4, p. 798-807
  • P53 on the crossroad between regeneration and cancer

    Authors: Charni M., Aloni-Grinstein R., Molchadsky A. & Rotter V. (2017), Cell Death and Differentiation. 24, 1, p. 8-14
  • The nonreceptor tyrosine kinase c-Src attenuates SCF(β-TrCP) E3-ligase activity abrogating Taz proteasomal degradation

    Authors: Shanzer M., Adler J., Ricardo Lax L. I., Reuven N. & Shaul Y. (2017), Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1678-1683
  • Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues

    Authors: Chai C., Rivkin M., Berkovits L., Simerzin A., Zorde-Khvalevsky E., Rosenberg N., Klein S., Yaish D., Durst R., Shpitzen S., Udi S., Tam J., Heeren J., Worthmann A., Schramm C., Kluwe J., Ravid R., Hornstein E., Giladi H. & Galun E. (2017), Gastroenterology. 153, 5, p. 1404-1415
  • Can immunotherapy treat neurodegeneration?

    Authors: Schwartz M. (2017),
  • From Prokaryotes to Cancer: Glutamine Flux in Multicellular Units

    Authors: Erez A. & Kolodkin-Gal I. (2017), Trends in Endocrinology and Metabolism. 28, 9, p. 637-644
  • Fast Vascular Ultrasound Imaging With Enhanced Spatial Resolution and Background Rejection

    Authors: Bar-Zion A., Tremblay-Darveau C., Solomon O., Adam D. & Eldar Y. C. (2017), IEEE Transactions on Medical Imaging. 36, 1, p. 169-180, 7543469
  • Tumor Suppression by p53: Bring in the Hippo!

    Authors: Aylon Y. & Oren M. (2017), Cancer Cell. 32, 4, p. 397-399
  • Next-Generation Proteomics and Its Application to Clinical Breast Cancer Research

    Authors: Mardamshina M. & Geiger T. (2017), The American journal of pathology. 187, 10, p. 2175-2184
  • Activation of Signaling Cascades by Weak Extremely Low Frequency Electromagnetic Fields

    Authors: Kapri-Pardes E., Hanoch T., Maik-Rachline G., Murbach M., Bounds P. L., Kuster N. & Seger R. (2017), Cellular Physiology and Biochemistry. 43, 4, p. 1533-1546
  • Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells

    Authors: Panayotopoulou E. G., Müller A. K., Börries M., Busch H., Hu G. & Lev S. (2017), Oncotarget. 8, 28, p. 45088-45104
  • Immune deficiency augments the prevalence of p53 loss of heterozygosity in spontaneous tumors but not bi-directional loss of heterozygosity in bone marrow progenitors

    Authors: Shetzer Y., Napchan Y., Kaufman T., Molchadsky A., Tal P., Goldfinger N. & Rotter V. (2017), International Journal of Cancer. 140, 6, p. 1364-1369
  • The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element

    Authors: Marin-Bejar O., Mas A. M., Gonzalez J., Martinez D., Athie A., Morales X., Galduroz M., Raimondi I., Grossi E., Guo S., Rouzaut A., Ulitsky I. & Huarte M. (2017), GENOME BIOLOGY. 18, 202
  • Von Hippel-Lindau and hereditary pheochromocytoma/paraganglioma syndromes: Clinical features, genetics, and surveillance recommendations in childhood

    Authors: Rednam S. P., Erez A., Druker H., Janeway K. A., Kamihara J., Kohlmann W. K., Nathanson K. L., States L. J., Tomlinson G. E., Villani A., Voss S. D., Schiffman J. D. & Wasserman J. D. (2017), Clinical Cancer Research. 23, 12, p. e68-e75
  • Integrating multiple fitting regression and Bayes decision for cancer diagnosis with transcriptomic data from tumor-educated blood platelets

    Authors: Huang G., Yuan M., Chen M., Li L., You W., Li H., Cai J. J. & Ji G. (2017), Analyst. 142, 19, p. 3588-3597
  • Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs

    Authors: Yogev O., Henderson S., Hayes M. J., Marelli S. S., Ofir-Birin Y., Regev-Rudzki N., Herrero J. & Enver T. (2017), PLoS Pathogens. 13, 8, e1006524
  • The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway

    Authors: Furth N. & Aylon Y. (2017), Cell Death and Differentiation. 24, 9, p. 1488-1501
  • The microbiome in anti-cancer therapy

    Authors: Bashiardes S., Tuganbaev T., Federici S. & Elinav E. (2017), Seminars in Immunology. 32, p. 74-81
  • FXYD5 (dysadherin) may mediate metastatic progression through regulation of the beta-Na+-K+-ATPase subunit in the 4T1 mouse breast cancer model

    Authors: Lubarski-Gotliv I., Dey K., Kuznetsov Y., Kalchenco V., Asher C. & Garty H. (2017), American Journal Of Physiology-Cell Physiology. 313, 1, p. C108-C117
  • Lymphocyte activation gene 3: A novel therapeutic target in chronic lymphocytic leukemia

    Authors: Shapiro M., Herishanu Y., Ben-Zion-Katz, Dezorella N., Sun C., Kay S., Polliack A., Avivi I., Wiestner A. & Perry C. (2017), Haematologica. 102, 5, p. 874-882
  • Classification of high-grade glioma into tumor and nontumor components using support vector machine

    Authors: Blumenthal D. T., Artzi M., Liberman G., Bokstein F., Aizenstein O. & Ben Bashat B. D. (2017), American Journal of Neuroradiology. 38, 5, p. 908-914
  • Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival

    Authors: Bublik D. R., Bursac S., Sheffer M., Orsolic I., Shalit T., Tarcic O., Kotler E., Mouhadeb O., Hoffman Y., Fuchs G., Levin Y., Volarevic S. & Oren M. (2017), Proceedings of the National Academy of Sciences of the United States of America. 114, 4, p. E496-E505
  • McPAS-TCR: A manually curated catalogue of pathology-associated T cell receptor sequences

    Authors: Tickotsky N., Sagiv T., Prilusky J., Shifrut E. & Friedman N. (2017), Bioinformatics. 33, 18, p. 2924-2929
  • SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress

    Authors: Zipin-Roitman A., Aqaqe N., Yassin M., Biechonski S., Amar M., van Delft D. M. F., Gan O. I., McDermott S. P., Buzina A., Ketela T., Shlush L. I., Xie S., Voisin V., Moffat J., Minden M. D., Dick J. E. & Milyavsky M. (2017), Oncotarget. 8, 10, p. 16712-16727
  • Cancer and central nervous system tumor surveillance in pediatric neurofibromatosis 1

    Authors: Evans D. G. R., Salvador H., Chang V. Y., Erez A., Voss S. D., Schneider K. W., Scott H. S., Plon S. E. & Tabori U. (2017), Clinical Cancer Research. 23, 12, p. e46-e53
  • Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

    Authors: Lavin Y., Kobayashi S., Leader A., Amir E. D., Elefant N., Bigenwald C., Remark R., Sweeney R., Becker C. D., Levine J. H., Meinhof K., Chow A., Kim-Shulze S., Wolf A., Medaglia C., Li H., Rytlewski J. A., Emerson R. O., Solovyov A., Greenbaum B. D., Sanders C., Vignali M., Beasley M. B., Flores R., Gnjatic S., Pe'er D., Rahman A., Amit I. & Merad M. (2017), Cell. 169, 4, p. 750-765.e17
  • Pyruvate dehydrogenase has a major role in mast cell function, and its activity is regulated by mitochondrial microphthalmia transcription factor

    Authors: Sharkia I., Hadad Erlich T., Landolina N., Assayag M., Motzik A., Rachmin I., Kay G., Porat Z., Tshori S., Berkman N., Levi-Schaffer F. & Razin E. (2017), Journal of Allergy and Clinical Immunology. 140, 1, p. 204-214.e8
  • BCAT1 restricts alpha KG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

    Authors: Raffel S., Falcone M., Kneisel N., Hansson J., Wang W., Lutz C., Bullinger L., Poschet G., Nonnenmacher Y., Barnert A., Bahr C., Zeisberger P., Przybylla A., Sohn M., Toenjes M., Erez A., Adler L., Jensen P., Scholl C., Froehling S., Cocciardi S., Wuchter P., Thiede C., Floercken A., Westermann J., Ehninger G., Lichter P., Hiller K., Hell R., Herrmann C., Ho A. D., Krijgsveld J., Radlwimmer B. & Trumpp A. (2017), Nature. 551, 7680, p. 384-388
  • Increased potency of a bi-specific TL1A-ADAM17 (TACE) inhibitor by cell surface targeting

    Authors: Weizman T., Levin I., Zaretsky M., Sagi I. & Aharoni A. (2017), Frontiers in Molecular Biosciences. 4, AUG, 61
  • p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis

    Authors: Napoletano F., Gibert B., Yacobi-Sharon K., Vincent S., Favrot C., Mehlen P., Girard V., Teil M., Chatelain G., Walter L., Arama E. & Mollereau B. (2017), PLoS Genetics. 13, 9, e1007024
  • Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells

    Authors: Arafeh R., Flores K., Keren-Paz A., Maik-Rachline G., Gutkind N., Rosenberg S., Seger R. & Samuels Y. (2017), Scientific Reports. 7, 16345
  • A recombinant fungal compound induces anti-proliferative and pro-apoptotic effects on colon cancer cells

    Authors: Nimri L., Spivak O., Tal D., Schälling D., Peri I., Graeve L., Salame T. M., Yarden O., Hadar Y. & Schwartz B. (2017), Oncotarget. 8, 17, p. 28854-28864
  • Death by over-eating: The Gaucher disease associated gene GBA1, identified in a screen for mediators of autophagic cell death, is necessary for developmental cell death in Drosophila midgut

    Authors: Dasari S. K., Schejter E., Bialik S., Shkedy A., Levin-Salomon V., Levin-Zaidman S. & Kimchi A. (2017), Cell Cycle. 16, 21, p. 2003-2010
  • Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases

    Authors: Rachman-Tzemah C., Zaffryar-Eilot S., Grossman M., Ribero D., Timaner M., Mäki J. M., Myllyharju J., Bertolini F., Hershkovitz D., Sagi I., Hasson P. & Shaked Y. (2017), Cell Reports. 19, 4, p. 774-784
  • miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis

    Authors: Kfir-Erenfeld S., Haggiag N., Biton M., Stepensky P., Assayag-Asherie N. & Yefenof E. (2017), Oncotarget. 8, 1, p. 472-489
  • Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome

    Authors: Schwartzman O., Savino A. M., Gombert M., Palmi C., Cario G., Schrappe M., Eckert C., von Stackelberg A., Huang J., Hameiri-Grossman M., Avigad S., te Kronnie G., Geron I., Birger Y., Rein A., Zarfati G., Fischer U., Mukamel Z., Stanulla M., Biondi A., Cazzaniga G., Vetere A., Wagner B. K., Chen Z., Chen S., Tanay A., Borkhardt A. & Izraeli S. (2017), Proceedings Of The National Academy Of Sciences Of The United States Of America-Physical Sciences. 114, 20, p. E4030-E4039
  • Synonymous Somatic Variants in Human Cancer Are Not Infamous: A Plea for Full Disclosure in Databases and Publications

    Authors: Soussi T., Taschner P. E. M. & Samuels Y. (2017), Human Mutation. 38, 4, p. 339-342
  • Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase

    Authors: Cingolani F., Simbari F., Luis Abad A. J., Casasampere M., Fabrias G., Futerman A. H. & Casas J. (2017), Journal of Lipid Research. 58, 8, p. 1500-1513
  • Tracing the origins of relapse in acute myeloid leukaemia to stem cells

    Authors: Shlush L. I., Mitchell A., Heisler L., Abelson S., Ng S. W. K., Trotman-Grant A., Medeiros J. J. F., Rao-Bhatia A., Jaciw-Zurakowsky I., Marke R., McLeod J. L., Doedens M., Bader G., Voisin V., Xu C., McPherson J. D., Hudson T. J., Wang J. C. Y., Minden M. D. & Dick J. E. (2017), Nature. 547, 7661, p. 104-108
  • Bombesin antagonist-based radiotherapy of prostate cancer combined with WST-11 vascular targeted photodynamic therapy

    Authors: Kim K., Zhang H., La Rosa R. S., Jebiwott S., Desai P., Kimm S., Scherz A., O'Donoghue J. A., Weber W. A. & Coleman J. A. (2017), Clinical Cancer Research. 23, 13, p. 3343-3351
  • Spontaneous Activation of Antigen-presenting Cells by Genes Encoding Truncated Homo-Oligomerizing Derivatives of CD40

    Authors: Levin N., Pato A., Cafri G., Eisenberg G., Peretz T., Margalit A., Lotem M. & Gross G. (2017), Journal of Immunotherapy. 40, 2, p. 39-50
  • Post-translational regulation of p53 function through 20S proteasome-mediated cleavage

    Authors: Solomon H., Brauning B., Fainer I., Ben-Nissan G., Rabani S., Goldfinger N., Moscovitz O., Shakked Z., Rotter V. & Sharon M. (2017), Cell Death and Differentiation. 24, p. 2187-2198
  • Pancreatic cancer ascites xenograft-an expeditious model mirroring advanced therapeutic resistant disease

    Authors: Golan T., Stossel C., Schvimer M., Atias D., Halperin S., Buzhor E., Raitses Gurevich G. M., Cohen K., Pri-Chen S., Wilson J., Denroche R. E., Lungu I., Bartlett J. M. S., Mbabaali F., Yarden Y., Nataraj N. B., Gallinger S. & Berger R. (2017), Oncotarget. 8, 25, p. 40778-40790
  • Cancer and central nervous system tumor surveillance in pediatric neurofibromatosis 2 and related disorders

    Authors: Evans D. G. R., Salvador H., Chang V. Y., Erez A., Voss S. D., Druker H., Scott H. S. & Tabori U. (2017), Clinical Cancer Research. 23, 12, p. e54-e61
  • The cancer paradigms of mammalian regeneration: Can mammals regenerate as amphibians?

    Authors: Sarig R. & Tzahor E. (2017), Carcinogenesis. 38, 4, p. 359-366
  • AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia

    Authors: Zhou F., Liu Y., Rohde C., Pauli C., Gerloff D., Koehn M., Misiak D., Baeumer N., Cui C., Goellner S., Oellerich T., Serve H., Garcia-Cuellar M., Slany R., Maciejewski J. P., Przychodzen B., Seliger B., Klein H., Bartenhagen C., Berdel W. E., Dugas M., Taketo M. M., Farouq D., Schwartz S., Regev A., Hebert J., Sauvageau G., Pabst C., Huettelmaier S. & Mueller-Tidow C. (2017), Nature Cell Biology. 19, 7, p. 844-855
  • The Leo Sachs’ legacy: A pioneer’s journey through hematopoiesis

  • Genetic and Functional Analysis of GRIN2A in Tumor Samples

    Authors: Prickett T. D., Gartner J. J. & Samuels Y. (2017), NMDA Receptors. p. 93-116
  • Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression

    Authors: Fiziev P., Akdemir K. C., Miller J. P., Keung E. Z., Samant N. S., Sharma S., Natale C. A., Terranova C. J., Maitituoheti M., Amin S. B., Martinez-Ledesma E., Dhamdhere M., Axelrad J. B., Shah A., Cheng C. S., Mahadeshwar H., Seth S., Barton M. C., Protopopov A., Tsai K. Y., Davies M. A., Garcia B. A., Amit I., Chin L., Ernst J. & Rai K. (2017), Cell Reports. 19, 4, p. 875-889
  • Diverse continuum of CD4+ T-cell states is determined by hierarchical additive integration of cytokine signals

    Authors: Eizenberg-Magar I., Rimer J., Zaretsky I., Lara-Astiaso D., Reich-Zeliger S. & Friedman N. (2017), Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. E6447-E6456
  • Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function

    Authors: Gropper Y., Feferman T., Shalit T., Salame T. M., Porat Z. & Shakhar G. (2017), Cell Reports. 20, 11, p. 2547-2555
  • Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

    Authors: Arce Vargas F., Furness A. J., Solomon I., Joshi K., Mekkaoui L., Lesko M. H., Miranda Rota E., Dahan R., Georgiou A., Sledzinska A., Ben Aissa A., Franz D., Werner Sunderland M., Wong Y. N. S., Henry J. Y., O'Brien T., Nicol D., Challacombe B., Beers S. A. & Spain L. (2017), Immunity. 46, 4, p. 577-586
  • Recommendations for surveillance for children with leukemia-predisposing conditions

    Authors: Porter C. C., Druley T. E., Erez A., Kuiper R. P., Onel K., Schiffman J. D., Schneider K. W., Scollon S. R., Scott H. S., Strong L. C., Walsh M. F. & Nichols K. E. (2017), Clinical Cancer Research. 23, 11, p. e14-e22
  • RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer

    Authors: Tarcic O., Granit R. Z., Pateras I. S., Masury H., Maly B., Zwang Y., Yarden Y., Gorgoulis V. G., Pikarsky E., Ben-Porath I. & Oren M. (2017), Cell Death and Differentiation. 24, 4, p. 694-704
  • Receptor Protein Tyrosine Phosphatase alpha-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice

    Authors: Stanford S. M., Svensson M. N. D., Sacchetti C., Pilo C. A., Wu D. J., Kiosses W. B., Hellvard A., Bergum B., Muench G. R. A., Elly C., Liu Y., den Hertog J., Elson A., Sap J., Mydel P., Boyle D. L., Corr M., Firestein G. S. & Bottini N. (2016), Arthritis & Rheumatology. 68, 2, p. 359-369
  • TMPRSS2-ERG fusion protein regulates insulin-like growth factor-1 receptor (IGF1R) gene expression in prostate cancer: Involvement of transcription factor Sp1

    Authors: Meisel Sharon S., Pozniak Y., Geiger T. & Werner H. (2016), Oncotarget. 7, 32, p. 51375-51392
  • Co-targeting of Adenosine Signaling Pathways for Immunotherapy: Potentiation by Fc Receptor Engagement

    Authors: Dahan R. & Ravetch J. V. (2016),
  • Measurement of lymphocyte aggregation by flow cytometry-physiological implications in chronic lymphocytic leukemia

    Authors: Dezorella N., Kay S., Baron S., Shapiro M., Porat Z., Deutsch V., Herishanu Y. & Katz B. (2016), Cytometry. Part B, Clinical cytometry. 90, 3, p. 257-266
  • Wnt signaling in cancer stem cells and colon cancer metastasis

    Authors: Basu S., Haase G. & Ben-Ze'ev A. (2016), F1000Research. 5, 699
  • MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

    Authors: Yu J., Lei R., Zhuang X., Li X., Li G., Lev S., Segura M., Zhang X. & Hu G. (2016), Nature Communications. 7, 13884
  • p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression

    Authors: Drayman N., Ben-nun-Shaul O., Butin-Israeli V., Srivastava R., Rubinstein A. M., Mock C. S. & Elyada E. (2016), Oncotarget. 7, 33, p. 52643-52660
  • The Relationship Between Plasma Cytokine Levels and Response to Selective Serotonin Reuptake Inhibitor Treatment in Children and Adolescents with Depression and/or Anxiety Disorders

    Authors: Amitai M., Taler M., Carmel M., Michaelovsky E., Eilat T., Yablonski M., Orpaz N., Chen A., Apter A., Weizman A. & Fennig S. (2016), Journal of Child and Adolescent Psychopharmacology. 26, 8, p. 727-732
  • Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells

    Authors: Kozela E., Juknat A., Gao F., Kaushansky N., Coppola G. & Vogel Z. (2016), Journal of Neuroinflammation. 13, 1, 136
  • NKG2D ligands mediate immunosurveillance of senescent cells

    Authors: Sagiv A., Burton D., Moshayev Z., Vadai E., Wensveen F., Ben-Dor S., Golani O., Polic B. & Krizhanovsky V. (2016), AGING-US. 8, 2, p. 328-344
  • Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

    Authors: Rodgers D. T., Mazagova M., Hampton E. N., Cao Y., Ramadoss N. S., Hardy I. R., Schulman A., Du J., Wang F., Singer O., Ma J., Nunez V., Shen J., Woods A. K., Wright T. M., Schultz P. G., Kim C. H. & Young T. S. (2016), Proceedings of the National Academy of Sciences of the United States of America. 113, 4, p. E459-E468
  • Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

    Authors: Georgoudaki A. M., Prokopec K. E., Boura V. F., Hellqvist E., Sohn S., Östling J., Dahan R., Harris R. A., Rantalainen M., Klevebring D., Sund M., Brage S. E., Fuxe J., Rolny C., Li F., Ravetch J. V. & Karlsson M. C. (2016), Cell Reports. 15, 9, p. 2000-2011
  • LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer

    Authors: Sas-Chen A., Aure M. R., Leibovich L., Carvalho S., Enuka Y., Korner C., Polycarpou-Schwarz M., Lavi S., Nevo N., Kuznetsov Y., Yuan J., Azuaje F., Ulitsky I., Diederichs S., Wiemann S., Yakhini Z., Kristensen V. N., Borresen-Dale A. & Yarden Y. (2016), EMBO Molecular Medicine. 8, 9, p. 1052-1064
  • The relationship between the nucleolus and cancer: Current evidence and emerging paradigms

    Authors: Orsolic I., Jurada D., Pullen N., Oren M., Eliopoulos A. G. & Volarevic S. (2016), Seminars in Cancer Biology. 37-38, p. 36-50
  • Tumor macrophages are pivotal constructors of tumor collagenous matrix

    Authors: Afik R., Zigmond E., Vugman M., Klepfish M., Shimshoni E., Pasmanik-Chor M., Shenoy A., Bassat E., Halpern Z., Geiger T., Sagi I. & Varol C. (2016), Journal of Experimental Medicine. 213, 11, p. 2315-2331
  • The Hippo pathway, p53 and cholesterol

    Authors: Aylon Y. & Oren M. (2016), Cell cycle (Georgetown, Tex.). 15, 17, p. 2248-2255
  • Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

    Authors: Yosef R., Pilpel N., Tokarsky-Amiel R., Biran A., Ovadya Y., Cohen S., Vadai E., Dassa L., Shahar E., Condiotti R., Ben-Porath I. & Krizhanovsky V. (2016), Nature Communications. 7, 11190
  • Oncogenic mutant p53 gain of function nourishes the vicious cycle of tumor development and cancer stem-cell formation

    Authors: Shetzer Y., Molchadsky A. & Rotter V. (2016), Cold Spring Harbor perspectives in medicine. 6, 10, a026203
  • System-wide Clinical Proteomics of Breast Cancer Reveals Global Remodeling of Tissue Homeostasis

    Authors: Pozniak Y., Balint-Lahat N., Rudolph J. D., Lindskog C., Katzir R., Avivi C., Pontén F., Ruppin E., Barshack I. & Geiger T. (2016), Cell Systems. 2, 3, p. 172-184
  • FXYD5 Protein Has a Pro-inflammatory Role in Epithelial Cells

    Authors: Lubarski-Gotliv I., Asher C., Dada L. A. & Garty H. (2016), Journal of Biological Chemistry. 291, 21, p. 11072-11082, 27006401
  • Analysis of subcellular RNA fractions revealed a transcription- independent effect of tumor necrosis factor alpha on splicing, mediated by Spt5

    Authors: Diamant G., Eisenbaum T., Leshkowitz D. & Dikstein R. (2016), Molecular and Cellular Biology. 36, 9, p. 1342-1353
  • Adipose-induced retroperitoneal soft tissue sarcoma tumorigenesis: A potential crosstalk between sarcoma and fat cells

    Authors: Loewenstein S., Lubezky N., Nizri E., Zemel M., Levin Y., Savidor A., Sher O., Klausner J. & Lahat G. (2016), Molecular Cancer Research. 14, 12, p. 1254-1265
  • The cybernetics of TNF: Old views and newer ones

  • mRNA-based dendritic cell immunization improves survival in ret transgenic mouse melanoma model

    Authors: Sharbi-Yunger A., Grees M., Tzehoval E., Utikal J., Umansky V. & Eisenbach L. (2016), OncoImmunology. 5, 6, e1160183
  • Mutational and network level mechanisms underlying resistance to anti-cancer kinase inhibitors

    Authors: Mancini M. & Yarden Y. (2016), SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 50, p. 164-176
  • Interfering with the Dimerization of the ERBB Receptors by Transmembrane Domain-Derived Peptides Inhibits Tumorigenic Growth in Vitro and in Vivo

    Authors: Bublil E. M., Cohen T., Arnusch C. J., Peleg A., Pines G., Lavi S. & Yarden Y. (2016), Biochemistry. 55, 39, p. 5520-5530
  • Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells

    Authors: Grespi F., Landré V., Molchadsky A., Di Daniele N., Marsella L. T., Melino G. & Rotter V. (2016), Cell Death & Disease. 7, 12, e2567
  • The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation

    Authors: Aylon Y., Gershoni A., Rotkopf R., Biton I. E., Porat Z., Koh A. P., Sun X., Lee Y., Fiel M., Hoshida Y., Friedman S. L., Johnson R. L. & Oren M. (2016), GENES & DEVELOPMENT. 30, 7, p. 786-797
  • ESMO/ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016

    Authors: Dittrich C., Kosty M., Jezdic S., Pyle D., Berardi R., Bergh J., El-Saghir N., Lotz J. P., Österlund P., Pavlidis N., Purkalne G., Awada A., Banerjee S., Bhatia S., Bogaerts J., Buckner J., Cardoso F., Casali P., Chu E., Close J. L., Coiffier B., Connolly R., Coupland S., De Petris L., De Santis M., De Vries E. G., Dizon D. S., Duff J., Duska L. R., Eniu A., Ernstoff M., Felip E., Fey M. F., Gilbert J., Girard N., Glaudemans A. W., Gopalan P. K., Grothey A., Hahn S. M., Hanna D., Herold C., Herrstedt J., Homicsko K., Jones D. V., Jost L., Keilholz U., Khan S., Kiss A., Köhne C. H., Kunstfeld R., Lenz H. J., Lichtman S., Licitra L., Lion T., Litière S., Liu L., Loehrer P. J., Markham M. J., Markman B., Mayerhoefer M., Meran J. G., Michielin O., Moser E. C., Mountzios G., Moynihan T., Nielsen T., Ohe Y., Öberg K., Palumbo A., Peccatori F. A., Pfeilstöcker M., Raut C., Remick S. C., Robson M., Rutkowski P., Salgado R., Schapira L., Schernhammer E., Schlumberger M., Schmoll H. J., Schnipper L., Sessa C., Shapiro C. L., Steele J., Sternberg C. N., Stiefel F., Strasser F., Stupp R., Sullivan R., Tabernero J., Travado L., Verheij M., Voest E., Vokes E., Von Roenn J., Weber J. S., Wildiers H. & Yarden Y. (2016), ESMO Open. 1, 5, e000097
  • P53 mutations promote proteasomal activity

    Authors: Oren M. & Kotler E. (2016),
  • Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape

    Authors: Li Q., Wennborg A., Aurell E., Dekel E., Zou J., Xu Y., Huang S. -. J. & Ernberg I. (2016), Proceedings of the National Academy of Sciences of the United States of America. 113, 10, p. 2672-2677
  • Non-alcoholic fatty liver and the gut microbiota

    Authors: Bashiardes S., Shapiro H., Rozin S., Shibolet O. & Elinav E. (2016), Molecular Metabolism. 5, 9, p. 782-794
  • Widespread parainflammation in human cancer

    Authors: Aran D., Lasry A., Zinger A., Biton M., Pikarsky E., Hellman A., Butte A. J. & Ben-Neriah Y. (2016), Genome Biology. 17, 1, 145
  • A metabolic link between the urea cycle and cancer cell proliferation

    Authors: Nagamani S. C. S. & Erez A. (2016), Molecular & cellular oncology. 3, 2, 1127314
  • Tumor cell invasion can be blocked by modulators of collagen fibril alignment that control assembly of the extracellular matrix

    Authors: Grossman M., Ben-Chetrit N., Zhuravlev A., Afik R., Bassat E., Solomonov I., Yarden Y. & Sagi I. (2016), Cancer Res.. 76, 14, 052206
  • Treatment Effects of WST11 Vascular Targeted Photodynamic Therapy for Urothelial Cell Carcinoma in Swine

    Authors: Murray K. S., Winter A. G., Corradi R. B., LaRosa S., Jebiwott S., Somma A., Takaki H., Srimathveeravalli G., Lepherd M., Monette S., Kim K., Scherz A. & Coleman J. A. (2016), Journal of Urology. 196, 1, p. 236-243
  • Estrogen Receptor-Targeted Contrast Agents for Molecular Magnetic Resonance Imaging of Breast Cancer Hormonal Status

    Authors: Pais A. & Degani H. (2016), Frontiers in Oncology. 6, 100
  • Tumor Necrosis Factor Alpha (TNFalpha)

    Authors: Wallach D. & Kovalenko A. (2016), Compendium of Inflammatory Diseases.
  • Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma

    Authors: Grossman I., Ilani T., Fleishman S. & Fass D. (2016), Protein engineering, design & selection : PEDS. 29, 4, p. 135-147
  • Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation

    Authors: Charni M., Molchadsky A., Goldstein I., Solomon H., Tal P., Goldfinger N., Yang P., Porat Z., Lozano G. & Rotter V. (2016), Cell Death and Differentiation. 23, 3, p. 509-520
  • Parkinson disease (PARK) genes are somatically mutated in cutaneous melanoma

    Authors: Inzelberg R., Samuels Y., Azizi E., Qutob N., Inzelberg L., Domany E., Schechtman E. & Friedman E. (2016), Neurology: Genetics. 2, 3, e70
  • The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells

    Authors: Revach O. Y., Winograd-Katz S. E., Samuels Y. & Geiger B. (2016), Experimental Cell Research. 343, 1, p. 82-88
  • The evolution of T-cell depletion in haploidentical stem-cell transplantation

    Authors: Or Geva N. & Reisner Y. (2016), British Journal of Haematology. 172, 5, p. 667-684
  • Microglia Replenished OHSC: A Culture System to Study In Vivo Like Adult Microglia

    Authors: Masuch A., van der Pijl d. P. R., Fuener L., Wolf Y., Eggen B., Boddeke E., Biber K., Dalimot J., Bergmueller E., Jung S., Voortman S., Winterhager E., Brandau S., Garbi N., Kurrer M., Eriksson U., Gunzer M. & Hasenberg M. (2016), GLIA. 64, 8, p. 1285-1297
  • Breast MRI: Malignant Cystosarcoma Phyllodes Tumor Exhibits Unique Anisotropic Diffusion

    Authors: Nissan N., Ben-Aharon U. & Yosepovich A. (2016), Israel Medical Association Journal. 18, p. 368-369
  • Optimization of DCE-MRI protocol for the assessment of patients with brain tumors

    Authors: Artzi M., Liberman G., Nadav G., Blumenthal D. T., Bokstein F., Aizenstein O. & Bashat D. B. (2016), Magnetic Resonance Imaging. 34, 9, p. 1242
  • Immunotherapy of cancer: From monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR Review 18

    Authors: Carvalho S., Levi-Schaffer F., Sela M. & Yarden Y. (2016), British Journal of Pharmacology. 173, 9, p. 1407-1424
  • Post-translational modification profiling - A novel tool for mapping the protein modification landscape in cancer

    Authors: Eisenberg-Lerner A., Ciechanover A. & Merbl Y. (2016), Experimental Biology and Medicine. 241, 14, p. 1475-1482
  • An antibody to amphiregulin, an abundant growth factor in patients' fluids, inhibits ovarian tumors

    Authors: Carvalho S., Lindzen M., Lauriola M., Shirazi N., Sinha S., Abdul-Hai A., Levanon K., Korach J., Barshack I., Cohen Y., Onn A., Mills G. & Yarden Y. (2016), Oncogene. 35, 4, p. 438-447
  • Adjuvant Autologous Melanoma Vaccine for Macroscopic Stage III Disease: Survival, Biomarkers, and Improved Response to CTLA-4 Blockade

    Authors: Lotem M., Merims S., Frank S., Hamburger T., Nissan A., Kadouri L., Cohen J., Straussman R., Eisenberg G., Frankenburg S., Carmon E., Alaiyan B., Shneibaum S., Ayyildiz Z. O., Isbilen M., Senses K. M., Ron I., Steinberg H., Smith Y., Shiloni E., Gure A. O. & Peretz T. (2016), Journal of Immunology Research. 2016, 8121985
  • Genetic and pharmacological modulation of Akt1 for improving ovarian graft revascularization in a mouse model

    Authors: Cohen Y., Dafni H., Avni R., Fellus L., Bochner F., Rotkopf R., Raz T., Benjamin L. E., Walsh K. & Neeman M. (2016), Biology of Reproduction. 94, 1, 14
  • Extracellular matrix and tissue regeneration

    Authors: Mackiewicz Z., Konttinen Y. T., Kaivosoja E., Stegajev V., Wagner H. D., Levón J. & Tiainen V. M. (2016), Regenerative Medicine - from Protocol to Patient. Steinhoff G. (eds.). 3 ed. p. 1-55
  • Harnessing the natural inhibitory domain to control TNF alpha Converting Enzyme (TACE) activity in vivo

    Authors: Wong E., Cohen T., Romi E., Levin M., Peleg Y., Arad U., Yaron A., Milla M. E. & Sagi I. (2016), Scientific Reports. 6, 35598
  • Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms

    Authors: Zhang L., Cheng Q., Zhang L., Wang Y., Merrill G. F., Ilani T., Fass D., Arner E. S. J. & Zhang J. (2016), Free Radical Biology and Medicine. 99, p. 426-435
  • RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

    Authors: Tarcic O., Pateras I. S., Cooks T., Shema E., Kanterman J., Ashkenazi H., Boocholez H., Hubert A., Rotkopf R., Baniyash M., Pikarsky E., Gorgoulis V. G. & Oren M. (2016), Cell Reports. 14, 6, p. 1462-1476
  • Targeting mutant p53 for cancer therapy

    Authors: Oren M., Tal P. & Rotter V. (2016), AGING-US. 8, 6, p. 1159-1160
  • Emerging anti-cancer antibodies and combination therapies targeting HER3/ERBB3

    Authors: Gaborit N., Lindzen M. & Yarden Y. (2016), Human Vaccines & Immunotherapeutics. 12, 3, p. 576-592
  • Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

    Authors: Chou T. F., Chuang Y. T., Hsieh W. C., Chang P. Y., Liu H. Y., Mo S. T., Hsu T. S., Miaw S. C., Chen R. H., Kimchi A. & Lai M. Z. (2016), Nature Communications. 7, 11904
  • Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast

    Authors: Ragg R., Schilmann A. M., Korschelt K., Wieseotte C., Kluenker M., Viel M., Voelker L., Preiss S., Herzberger J., Frey H., Heinze K., Bluemler P., Tahir M. N., Natalio F. & Tremel W. (2016), Journal of Materials Chemistry B. 4, 46, p. 7423-7428
  • Genetic manipulation of iron biomineralization enhances MR relaxivity in a ferritin-M6A chimeric complex

    Authors: Radoul M., Lewin L., Cohen B., Oren R., Popov S., Davidov G., Vandsburger M. H., Harmelin A., Bitton R., Greneche J., Neeman M. & Zarivach R. (2016), Scientific Reports. 6, 26550
  • Androgen deprivation therapy potentiates the efficacy of vascular targeted photodynamic therapy of prostate cancer xenografts

    Authors: Kim K., Watson P. A., Jebiwott S., Somma A. J., La Rosa R. S. P., Mehta D., Murray K. S., Lilja H., Ulmert D., Scherz A. & Coleman J. A. (2016), Cancer Research. 76, 2016
  • Fibroblast recruitment as a tool for ovarian cancer detection and targeted therapy

    Authors: Oren R., Addadi Y., Haziza L. N., Dafni H., Rotkopf R., Meir G., Fishman A. & Neeman M. (2016), International Journal of Cancer. 139, 8, p. 1788-1798
  • A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors

    Authors: Gelfo V., Rodia M. T., Pucci M., Dall'Ora M., Santi S., Solmi R., Roth L., Lindzen M., Bonafe M., Bertotti A., Caramelli E., Lollini P., Trusolino L., Yarden Y., D'Uva G. & Lauriola M. (2016), Oncotarget. 7, 44, p. 72167-72183
  • Mutational scanning reveals the determinants of protein insertion and association energetics in the plasma membrane

    Authors: Assaf E., Weinstein J., Biran I., Fridman Y., Bibi E. & Fleishman S. (2016), eLife. 5, JANUARY2016, e12125
  • Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor

    Authors: Aghajanian H., Cho Y. K., Manderfield L. J., Herling M. R., Gupta M., Ho V. C., Li L., Degenhardt K., Aharonov A., Tzahor E. & Epstein J. A. (2016), Nature Communications. 7, 12038
  • MicroRNAs: Non-coding fine tuners of receptor tyrosine kinase signalling in cancer

    Authors: Donzelli S., Cioce M., Muti P., Strano S., Yarden Y. & Blandino G. (2016), SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 50, p. 133-142
  • A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

    Authors: Notta F., Chan-Seng-Yue M., Lemire M., Li Y., Wilson G. W., Connor A. A., Denroche R. E., Liang S. B., Brown A. M., Kim J. C., Wang T., Simpson J. T., Beck T., Borgida A., Buchner N., Chadwick D., Hafezi-Bakhtiari S., Dick J. E., Heisler L., Hollingsworth M. A., Ibrahimov E., Jang G. H., Johns J., Jorgensen L. G., Law C., Ludkovski O., Lungu I., Ng K., Pasternack D., Petersen G. M., Shlush L. I., Timms L., Tsao M. S., Wilson J. M., Yung C. K., Zogopoulos G., Bartlett J. M., Alexandrov L. B., Real F. X., Cleary S. P., Roehrl M. H., McPherson J. D., Stein L. D., Hudson T. J., Campbell P. J. & Gallinger S. (2016), Nature. 538, 7625, p. 378-382
  • A network-based analysis of colon cancer Splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1

    Authors: Hollander D., Donyo M., Atias N., Mekahel K., Melamed Z., Yannai S., Lev-Maor G., Shilo A., Schwartz S., Barshack I., Sharan R. & Ast G. (2016), Genome Research. 26, 4, p. 541-553
  • Use of HLA peptidomics and whole exome sequencing to identify human immunogenic neo-antigens

    Authors: Kalaora S., Barnea E., Merhavi-Shoham E., Qutob N., Teer J. K., Shimony N., Schachter J., Rosenberg S. A., Besser M. J., Admon A. & Samuels Y. (2016), Oncotarget. 7, 5, p. 5110-5117
  • The Anticancer Activity of Organotelluranes: Potential Role in Integrin Inactivation

    Authors: Silberman A., Kalechman Y., Hirsch S., Erlich Z., Sredni B. & Albeck A. (2016), ChemBioChem. 17, 10, p. 918-927
  • Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters

    Authors: Darash-Yahana M., Pozniak Y., Lu M., Sohn Y., Karmi O., Tamir S., Bai F., Song L., Jennings P. A., Pikarsky E., Geiger T., Onuchic J. N., Mittler R. & Nechushtai R. (2016), Proceedings of the National Academy of Sciences of the United States of America. 113, 39, p. 10890-10895
  • Can diffusion tensor anisotropy indices assist in breast cancer detection?

    Authors: Furman-Haran E., Grobgeld D., Nissan N., Shapiro-Feinberg M. & Degani H. (2016), Journal of Magnetic Resonance Imaging. 44, 6, p. 1624-1632
  • Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

    Authors: Tal P., Eizenberger S., Cohen E., Goldfinger N., Pietrokovski S., Oren M. & Rotter V. (2016), Oncotarget. 7, 11, p. 11817-11837
  • Proteomic maps of breast cancer subtypes

    Authors: Tyanova S., Albrechtsen R., Kronqvist P., Cox J., Mann M. & Geiger T. (2016), Nature Communications. 7, 10259
  • Therapeutic Potential of T Cell Chimeric Antigen Receptors (CARs) in Cancer Treatment: Counteracting Off-Tumor Toxicities for Safe CAR T Cell Therapy

    Authors: Gross G. & Eshhar Z. (2016), Annual Review of Pharmacology and Toxicology. 56, p. 59-+
  • Novel therapeutic compound tuftsin-phosphorylcholine attenuates collagen-induced arthritis

    Authors: Bashi T., Shovman O., Fridkin M., Volkov A., Barshack I., Blank M. & Shoenfeld Y. (2016), Clinical and Experimental Immunology. 184, 1, p. 19-28
  • Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease

    Authors: Yaeger R., Shah M. A., Miller V. A., Kelsen J. R., Wang K., Heins Z. J., Ross J. S., He Y., Sanford E., Yantiss R. K., Balasubramanian S., Stephens P. J., Schultz N., Oren M., Tang L. & Kelsen D. (2016), Gastroenterology. 151, 2, p. 278-287.e6
  • Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

    Authors: Hao Y., Samuels Y., Li Q., Krokowski D., Guan B., Wang C., Jin Z., Dong B., Cao B., Feng X., Xiang M., Xu C., Fink S., Meropol N. J., Xu Y., Conlon R. A., Markowitz S., Kinzler K. W., Velculescu V. E., Brunengraber H., Willis J. E., LaFramboise T., Hatzoglou M., Zhang G., Vogelstein B. & Wang Z. (2016), Nature Communications. 7, 11971
  • Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

    Authors: Stock K., Estrada M. F., Vidic S., Gjerde K., Rudisch A., Santo V. E., Barbier M., Blom S., Arundkar S. C., Selvam I., Osswald A., Stein Y., Gruenewald S., Brito C., Van Weerden W., Rotter V., Boghaert E., Oren M., Sommergruber W., Chong Y., De Hoogt R. & Graeser R. (2016), Scientific Reports. 6, 28951
  • The Proteome of Primary Prostate Cancer

    Authors: Iglesias-Gato D., Wikström P., Tyanova S., Lavallee C., Thysell E., Carlsson J., Hägglöf C., Cox J., Andrén O., Stattin P., Egevad L., Widmark A., Bjartell A., Collins C. C., Bergh A., Geiger T., Mann M. & Flores-Morales A. (2016), European Urology. 69, 5, p. 942-952
  • Role of the microbiome in non-gastrointestinal cancers

    Authors: Pevsner-Fischer M., Tuganbaev T., Meijer M., Zhang S., Zeng Z., Chen M. & Elinav E. (2016), World Journal of Clinical Oncology. 7, 2, p. 200-213
  • Differentiation between treatment-related changes and progressive disease in patients with high grade brain tumors using support vector machine classification based on DCE MRI

    Authors: Artzi M., Liberman G., Nadav G., Blumenthal D. T., Bokstein F., Aizenstein O. & Ben Bashat D. (2016), Journal of Neuro-Oncology. 127, 3, p. 515-524
  • Zooming in on selectins in cancer

    Authors: Kedmi R. & Peer D. (2016),
  • Vascular-Targeted Photodynamic Therapy in Prostate Cancer: From Bench to Clinic

    Authors: Scherz A., Salomon Y., Lindner U. & Coleman J. (2016), PHOTODYNAMIC MEDICINE: FROM BENCH TO CLINIC. p. 461-480
  • HER2-Targeted Polyinosine/Polycytosine Therapy Inhibits Tumor Growth and Modulates the Tumor Immune Microenvironment

    Authors: Zigler M., Shir A., Joubran S., Sagalov A., Edinger N., Lau J., Yu S., Mizraji G., Globerson Levin A., Sliwkowski M. X. & Levitzki A. (2016), Cancer Immunology Research. 4, 8, p. 688-697
  • The tumor as an organ: comprehensive spatial and temporal modeling of the tumor and its microenvironment.

    Authors: Bloch N. & Harel D. (2016), BMC Bioinformatics. 17, 1, 317
  • Parkin Somatic Mutations Link Melanoma and Parkinson's Disease

    Authors: Levin L., Srour S., Gartner J., Kapitansky O., Qutob N., Dror S., Golan T., Dayan R., Brener R., Ziv T., Khaled M., Schueler-Furman O., Samuels Y. & Levy C. (2016), Journal of Genetics and Genomics. 43, 6, p. 369-379
  • Tumor evolution inferred by patterns of microRNA expression through the course of disease, therapy, and recurrence in breast cancer

    Authors: Dadiani M., Ben-Moshe N. B., Paluch-Shimon S., Perry G., Balint N., Marin I., Pavlovski A., Morzaev D., Kahana-Edwin S., Yosepovich A., Gal-Yam E. N., Berger R., Barshack I., Domany E. & Kaufman B. (2016), Clinical Cancer Research. 22, 14, p. 3651-3662
  • Cellular heterogeneity mediates inherent sensitivity-specificity tradeoff in cancer targeting by Synthetic circuits

    Authors: Morel M., Shtrahman R., Rotter V., Nissim L. & Bar-Ziv R. H. (2016), Proceedings of the National Academy of Sciences of the United States of America. 113, 29, p. 8133-8138
  • A non-aggressive, highly efficient, enzymatic method for dissociation of human brain-tumors and brain-tissues to viable single-cells

    Authors: Volovitz I., Shapira N., Ezer H., Gafni A., Lustgarten M., Alter T., Ben-Horin I., Barzilai O., Shahar T., Kanner A., Fried I., Veshchev I., Grossman R. & Ram Z. (2016), BMC Neuroscience. 17, 30
  • Conjugation of methotrexate-amino derivatives to macromolecules through carboxylate moieties is superior over conventional linkage to amino residues: Chemical, cell-free and in vitro characterizations

    Authors: Cooper I., Fridkin M. & Shechter Y. (2016), PLoS ONE. 11, 7, e0158352
  • Increased number of volatile organic compounds over malignant glottic lesions

    Authors: Shoffel-Havakuk H., Frumin I., Lahav Y., Haviv L., Sobel N. & Halperin D. (2016), The Laryngoscope. 126, 7, p. 1606-1611
  • An essential role for UTX in resolution and activation of bivalent promoters

    Authors: Dhar S. S., Lee S., Chen K., Zhu G., Oh W., Allton K., Gafni O., Kim Y. Z., Tomoiga A. S., Barton M. C., Hanna J. H., Wang Z., Li W. & Lee M. G. (2016), Nucleic Acids Research. 44, 8, p. 3659-3674
  • SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course

    Authors: Dezorella N., Katz B., Shapiro M., Polliack A., Perry C. & Herishanu Y. (2016), Haematologica. 101, 12, p. 1553-1562
  • Erratum to: ‘Phosphoproteomic analysis reveals Smarcb1 dependent EGFR signaling in Malignant Rhabdoid tumor cells’

    Authors: Darr J., Klochendler A., Isaac S., Geiger T. & Eden A. (2016), Molecular Cancer. 15, 1, p. 14-14
  • The Wnt target gene L1 in colon cancer invasion and metastasis

    Authors: Haase G., Gavert N., Brabletz T. & Ben-Ze'ev A. (2016), Cancers. 8, 5, 27187476
  • Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity

    Authors: Kohnz R. A., Roberts L. S., DeTomaso D., Bideyan L., Yan P., Bandyopadhyay S., Goga A., Yosef N. & Nomura D. K. (2016), ACS Chemical Biology. 11, 8, p. 2131-2139
  • The EGFR-HER2 module: A stem cell approach to understanding a prime target and driver of solid tumors

    Authors: Schneider M. R. & Yarden Y. (2016), Oncogene. 35, 23, p. 2949-2960
  • Improved Doxorubicin Encapsulation and Pharmacokinetics of Ferritin-Fusion Protein Nanocarriers Bearing Proline, Serine, and Alanine Elements

    Authors: Falvo E., Tremante E., Arcovito A., Papi M., Elad N., Boffi A., Morea V., Conti G., Toffoli G., Fracasso G., Giacomini P. & Ceci P. (2016), Biomacromolecules. 17, 2, p. 514-522
  • The ERK cascade inhibitors: Towards overcoming resistance

    Authors: Maik-Rachline G. & Seger R. (2016), Drug Resistance Updates. 25, p. 1-12
  • Chronic centrosome amplification without tumorigenesis

    Authors: Vitre B., Holland A. J., Kulukian A., Shoshani O., Hirai M., Wang Y., Maldonado M., Cho T., Boubaker J., Swing D. A., Tessarollo L., Evans S. M., Fuchs E. & Cleveland D. W. (2015), Proceedings of the National Academy of Sciences of the United States of America. 112, 46, p. E6321-E6330
  • A statistical framework to model the meeting-in-the-middle principle using metabolomic data: application to hepatocellular carcinoma in the EPIC study

    Authors: Assi N., Fages A., Vineis P., Chadeau-Hyam M., Stepien M., Duarte-Salles T., Byrnes G., Boumaza H., Knueppel S., Kuehn T., Palli D., Bamia C., Boshuizen H., Bonet C., Overvad K., Johansson M., Travis R., Gunter M. J., Lund E., Dossus L., Elena-Herrmann B., Riboli E., Jenab M., Viallon V. & Ferrari P. (2015), Mutagenesis. 30, 6, p. 743-753
  • Examination of HER3 targeting in cancer using monoclonal antibodies

    Authors: Gaborit N., Abdul-Hai A., Mancini M., Lindzen M., Lavi S., Leitner O., Mounier L., Chentouf M., Dunoyer S., Ghosh M., Larbouret C., Chardes T., Bazin H., Pelegrine A., Sela M. & Yarden Y. (2015), Proceedings of the National Academy of Sciences of the United States of America. 112, 3, p. 839-844
  • Preleukemia: The normal side of cancer

    Authors: Shlush L. I. & Minden M. D. (2015), Current Opinion in Hematology. 22, 2, p. 77-84
  • AML evolution from preleukemia to leukemia and relapse

    Authors: Shlush L. I. & Mitchell A. (2015), Best Practice and Research: Clinical Haematology. 28, 2-3, p. 81-89
  • Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth

    Authors: Harel S., Ben-Moshe N., Aylon Y., Bublik D., Moskovits N., Toperoff G., Azaiza D., Biagoni F., Fuchs G., Wilder S., Hellman A., Blandino G., Domany E. & Oren M. (2015), Cell Death and Differentiation. 22, p. 1328-1340
  • FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis

    Authors: Dahan R., Sega E., Engelhardt J., Selby M., Korman A. J. & Ravetch J. V. (2015), Cancer Cell. 28, 3, p. 285-295
  • A principle of organization which facilitates broad Lamarckian-like adaptations by improvisation

    Authors: Soen Y., Knafo M. & Elgart M. (2015), Biology Direct. 10, 68
  • In the hunt for therapeutic targets: Mimicking the growth, metastasis, and stromal associations of early-stage lung cancer using a novel orthotopic animal model

    Authors: Weiss I. D., Ella E., Dominsky O., Smith Y., Abraham M., Wald H., Shlomai Z., Zamir G., Feigelson S. W., Shezen E., Bar-Shai A., Alon R., Izhar U., Peled A., Shapira O. M. & Wald O. (2015), Journal of Thoracic Oncology. 10, 1, p. 46-58
  • Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells

    Authors: Kozela E., Juknat A., Kaushansky N., Ben-Nun A., Coppola G. & Vogel Z. (2015), Journal of Neuroinflammation. 12, 1, p. 1, 52
  • An interactive tool for animating biology, and its use in spatial and temporal modeling of a cancerous tumor and its microenvironment

    Authors: Bloch N., Weiss G., Szekely S. & Harel D. (2015), PLoS ONE. 10, 7, e0133484
  • Erratum: A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism (vol 24, pg 242, 2013)

    Authors: Pribluda A., Elyada E., Wiener Z., Hamza H., Goldstein R. E., Biton M., Burstain I., Morgenstern Y., Brachya G., Billauer H., Biton S., Snir-Alkalay I., Vucic D., Schlereth K., Mernberger M., Stiewe T., Oren M., Alitalo K., Pikarsky E. & Ben-Neriah Y. (2015),
  • Development of APE1 enzymatic DNA repair assays: Low APE1 activity is associated with increase lung cancer risk

    Authors: Sevilya Z., Leitner Dagan Y., Pinchev M., Kremer R., Elinger D., Lejbkowicz F., Rennert H. S., Freedman L. S., Rennert G., Paz-Elizur T. & Livneh Z. (2015), Carcinogenesis. 36, 9, p. 982-991
  • Quantitative computerized western blotting in detail

    Authors: Talmi-Frank D., Jaffe C. L. & Baneth G. (2015), Western Blotting. p. 141-150
  • LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme

    Authors: Ali M., Saroha A., Pewzner-Jung Y. & Futerman A. H. (2015), FEBS Letters. 589, 17, p. 2213-2217
  • Phosphoproteomic analysis reveals Smarcb1 dependent EGFR signaling in Malignant Rhabdoid tumor cells

    Authors: Darr J., Klochendler A., Isaac S., Geiger T. & Eden A. (2015), Molecular Cancer. 14, 1, 167
  • The functional relevance of somatic synonymous mutations in melanoma and other cancers

    Authors: Gotea V., Gartner J. J., Qutob N., Elnitski L. & Samuels Y. (2015), Pigment Cell and Melanoma Research. 28, 6, p. 673-684
  • Next generation HLA-haploidentical HSCT

    Authors: Martelli M., Ianni M., Ruggeri L., Falzetti F., Carotti A., Reisner Y. & Velardi A. (2015), Bone Marrow Transplantation. 50, p. S63-S66
  • Endothelial thermotolerance impairs nanoparticle transport in tumors

    Authors: Bagley A. F., Scherz-Shouval R., Galie P. A., Zhang A. Q., Wyckoff J., Whitesell L., Chen C. S., Lindquist S. & Bhatia S. N. (2015), Cancer Research. 75, 16, p. 3522-3567
  • Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

    Authors: Dumez J. D., Milani J., Vuichoud B., Bornet A., Lalande-Martin J., Tea I., Yon M., Maucourt M., Deborde C., Moing A., Frydman L., Bodenhausen G., Jannin S. & Giraudeau P. (2015), Analyst. 140, 17, p. 5860-5863
  • Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation

    Authors: Kim H., Frederick D., Levesque M., Cooper Z., Feng Y., Krepler C., Brill L., Samuels Y., Hayward N., Perlina A., Piris A., Zhang T., Halaban R., Herlyn M., Brown K., Wargo J., Dummer R., Flaherty K. & Ronai Z. (2015), Cell Reports. 11, 9, p. 1458-1473
  • Combining three antibodies nullifies feedback-mediated resistance to erlotinib in lung cancer

    Authors: Mancini M., Gaborit N., Lindzen M., Salame T. M., Dall'Ora M., Sevilla-Sharon M., Abdul-Hai A., Downward J. & Yarden Y. (2015), Science Signaling. 8, 379, ra53
  • Genomic Classification of Cutaneous Melanoma

    Authors: Samuels Y. (2015), Cell. 161, 7, p. 1681-1696
  • Clonal evolution models of tumor heterogeneity

  • Clusterin, a gene enriched in intestinal stem cells, is required for L1-mediated colon cancer metastasis

    Authors: Shapiro B., Tocci P., Haase G., Gavert N. & Ben-Ze'ev A. (2015), Oncotarget. 6, 33, p. 34389-34401
  • Size controlled protein nanoemulsions for active targeting of folate receptor positive cells

    Authors: Loureiro A., Nogueira E., Azoia N. G., Sarria M. P., Abreu A. S., Shimanovich U., Rollett A., Harmark J., Hebert H., Guebitz G., Bernardes G. J. L., Preto A., Gomes A. C. & Cavaco-Paulo A. (2015), Colloids And Surfaces B-Biointerfaces. 135, p. 90-98
  • Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy

    Authors: Golomb L., Sagiv A., Pateras I., Maly A., Krizhanovsky V., Gorgoulis V., Oren M. & Ben-Yehuda A. (2015), Cell Death and Differentiation. 22, 11, p. 1764-1774
  • Messenger RNA encoding constitutively active toll-like receptor 4 enhances effector functions of human T cells.

    Authors: Pato A., Eisenberg G., Machlenkin A., Margalit A., Cafri G., Frankenburg S., Merims S., Peretz T., Lotem M. & Gross G. (2015), Clinical and Experimental Immunology. 182, 2, p. 220-229
  • PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition

    Authors: Verma N., Keinan O., Selitrennik M., Karn T., Filipits M. & Lev S. (2015), Nature Communications. 6, 6064
  • Label-free in vivo molecular imaging of underglycosylated mucin-1 expression in tumour cells

    Authors: Song X., Airan R. D., Arifin D. R., Bar-Shir A., Kadayakkara D. K., Liu G., Gilad A. A., van Zijl Z. P. C. M., McMahon M. T. & Bulte J. W. M. (2015), Nature Communications. 6, 6719
  • Mechanical interplay between invadopodia and the nucleus in cultured cancer cells

    Authors: Revach O., Weiner A., Rechav K., Sabanay I., Livne A. & Geiger B. (2015), Scientific Reports. 5, 9466
  • Target discovery for T cell therapy: Next steps to advance Immunotherapies

    Authors: Bot A., Brewer J. E., Eshhar Z., Frankel S. R., Hickman E., Jungbluth A. A., Morgan R., Peretz Y., Radvanyi L., Ramos C. A., Robbins P. F. & Wucherpfennig K. W. (2015), Journal for ImmunoTherapy of Cancer. 3, 1, 31
  • Chemical cross-linking and native mass spectrometry: A fruitful combination for structural biology

    Authors: Sinz A., Arlt C., Chorev D. & Sharon M. (2015), Protein Science. 24, 8, p. 1193-1209
  • TOOKAD® Soluble focal therapy: pooled analysis of three phase II studies assessing the minimally invasive ablation of localized prostate cancer

    Authors: Azzouzi A., Barret E., Bennet J., Moore C., Taneja S., Muir G., Villers A., Coleman J., Allen C., Scherz A. & Emberton M. (2015), World Journal of Urology. 33, 7, p. 945-953
  • Electron spin resonance microscopic imaging of oxygen concentration in cancer spheroids

    Authors: Hashem M., Weiler-Sagie M., Kuppusamy P., Neufeld G., Neeman M. & Blank A. (2015), JOURNAL OF MAGNETIC RESONANCE. 256, p. 77-85
  • Aging, clonal hematopoiesis and preleukemia: not just bad luck?

    Authors: Shlush L. I., Zandi S., Itzkovitz S. & Schuh A. C. (2015), International Journal of Hematology. 102, 5, p. 513-522
  • Development of pheochromocytoma in ceramide synthase 2 null mice

    Authors: Park W., Brenner O., Kogot-Levin A., Saada A., Merrill A., Pewzner-Jung Y. & Futerman A. H. (2015), Endocrine-Related Cancer. 22, 4, p. 623-632
  • Runx3 at the interface of immunity, inflammation and cancer

    Authors: Lotem J., Levanon D., Negreanu V., Bauer O., Hantisteanu S., Dicken J. & Groner Y. (2015), Biochimica Et Biophysica Acta-Reviews On Cancer. 1855, 2, p. 131-143
  • P53-dependent non-coding RNA networks in chronic lymphocytic leukemia

    Authors: Blume C. J., Hotz-Wagenblatt A., Hüllein J., Sellner L., Jethwa A., Stolz T., Slabicki M., Lee K., Sharathchandra A., Benner A., Dietrich S., Oakes C. C., Dreger P., Te Raa D., Kater A. P., Jauch A., Merkel O., Oren M., Hielscher T. & Zenz T. (2015), Leukemia. 29, 10, p. 2015-2023
  • Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer

    Authors: George B., Horn D., Bayo P., Zaoui K., Flechtenmacher C., Grabe N., Plinkert P., Krizhanovsky V. & Hess J. (2015), Cancer Letters. 358, 2, p. 191-199
  • Dispersal of an ancient retroposon in the TP53 promoter of Bovidae: Phylogeny, novel mechanisms, and potential implications for cow milk persistency

    Authors: Dekel Y., Machluf Y., Ben-Dor S., Yifa O., Stoler A., Ben-Shlomo I. & Bercovich D. (2015), BMC Genomics. 16, 1, 53
  • c-Abl forces YAP to switch sides.

    Authors: Keshet R., Reuven N. & Shaul Y. (2015), Molecular & cellular oncology. 2, 3, p. e995006, 27308475
  • Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles

    Authors: Ramishetti S., Kedmi R., Goldsmith M., Leonard F., Sprague A. G., Godin B., Gozin M., Cullis P. R., Dykxhoorn D. M. & Peer D. (2015), ACS Nano. 9, 7, p. 6706-6716
  • From mass cytometry to cancer prognosis

    Authors: Winter D. R., Ledergor G. & Amit I. (2015),
  • Down-regulation of LATS kinases alters p53 to promote cell migration

    Authors: Furth N., Bossel Ben-Moshe B. N., Pozniak Y., Porat Z., Geiger T., Domany E., Aylon Y. & Oren M. (2015), Genes and Development. 29, p. 2325-2330
  • Historic recollections: From polymers and proteins to autoimmunity and cancer.

  • Tumor-derived osteopontin reprograms normal mammary fibroblasts to promote inflammation and tumor growth in breast cancer

    Authors: Sharon Y., Raz Y., Cohen N., Ben-Shmuel A., Schwartz H., Geiger T. & Erez N. (2015), Cancer Research. 75, 6, p. 963-973
  • PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

    Authors: Cohen S. G., Itkin T., Chakrabarty S., Graf C., Kollet O., Ludin A., Golan K., Kalinkovich A., Ledergor G., Wong E., Niemeyer E., Porat Z., Erez A., Sagi I., Esmon C. T., Ruf W. & Lapidot T. (2015), Nature Medicine. 21, 11, p. 1307-1317
  • Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors

    Authors: Loureiro A., Bernardes G. J. L., Shimanovich U., Sarria M. P., Nogueira E., Preto A., Gomes A. C. & Cavaco-Paulo A. (2015), Nanomedicine: Nanotechnology, Biology, and Medicine. 11, 5, p. 1077-1083
  • Metabolic dysregulation in monogenic disorders and cancer-finding method in madness

    Authors: Erez A. & DeBerardinis R. J. (2015), Nature reviews. Cancer. 15, 7, p. 440-448
  • C-Abl antagonizes the YAP oncogenic function

    Authors: Keshet R. D., Adler J., Lax I. R., Shanzer M. H., Porat Z., Reuven N. & Shaul Y. (2015), Cell Death and Differentiation. 22, 6, p. 935-945
  • Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression

    Authors: Shvab A., Haase G., Ben Shmuel S. A., Gavert N., Brabletz T., Dedhar S. & Ben-Ze'ev A. (2015), Oncogene. 35, 5, p. 549-557
  • Overshoot during phenotypic switching of cancer cell populations

    Authors: Sellerio A., Ciusani E., Ben-Moshe N. B., Coco S., Piccinini A., Myers C., Sethna J., Giampietro C., Zapperi S. & La Porta P. C. (2015), Scientific Reports. 5, 15464
  • PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop

    Authors: Selitrennik M. & Lev S. (2015), Oncotarget. 6, 26, p. 22214-22226
  • Aptamer Targeting the ERBB2 Receptor Tyrosine Kinase for Applications in Tumor Therapy

    Authors: Mahlknecht G., Sela M. & Yarden Y. (2015), Gene Therapy of Solid Cancers. p. 3-15
  • The nuclear translocation of ERK1/2 as an anticancer target

    Authors: Plotnikov A., Flores K., Maik-Rachline G., Zehorai E., Kapri-Pardes E., Berti D. A., Hanoch T., Besser M. J. & Seger R. (2015), Nature Communications. 6, 6685
  • Determination of optimal drug dose and light dose index to achieve minimally invasive focal ablation of localised prostate cancer using WST11-vascular-targeted photodynamic (VTP) therapy

    Authors: Moore C. M., Azzouzi A., Barret E., Villers A., Muir G. H., Barber N. J., Bott S., Trachtenberg J., Arumainayagam N., Gaillac B., Allen C., Schertz A. & Emberton M. (2015), BJU International. 116, 6, p. 888-896
  • Photodynamic Quenched Cathepsin Activity Based Probes for Cancer Detection and Macrophage Targeted Therapy

    Authors: Ben-Nun Y., Merquiol E., Brandis A., Turk B., Scherz A. & Blum G. (2015), Theranostics. 5, 8, p. 847-862
  • Cancer immunotherapy: More is (much) better

    Authors: Yarden Y. & Sela M. (2015), Clinical Cancer Research. 21, 18, p. 4030-4032
  • Combined local blood-brain barrier opening and systemic methotrexate for the treatment of brain tumors

    Authors: Cooper I., Last D., Guez D., Sharabi S., Goldman S. E., Lubitz I., Daniels D., Salomon S., Tamar G., Tamir T., Mardor R., Fridkin M., Shechter Y. & Mardor Y. (2015), Journal of Cerebral Blood Flow and Metabolism. 35, 6, p. 967-976
  • Cardiac glycosides induced toxicity in human cells expressing α1-, α2-, or α3-isoforms of Na-K-ATPase

    Authors: Lev M., Karlish S. & Garty H. (2015), American Journal Of Physiology-Cell Physiology. 309, 2, p. C126-C135
  • Erratum to FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis [Cancer Cell 28, 285-295; September 14, 2015]

    Authors: Dahan R., Sega E., Engelhardt J., Selby M., Korman A. J. & Ravetch J. V. (2015),
  • The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner

    Authors: Shanzer M., Ricardo-Lax I., Keshet R., Reuven N. & Shaul Y. (2015), Oncogene. 34, 32, p. 4190-4198
  • Exercising 'veto' power to make haploidentical hematopoietic stem cell transplantation a safe modality for induction of immune tolerance

    Authors: Or Geva N. & Reisner Y. (2015), Regenerative Medicine. 10, 3, p. 239-242
  • MicroRNAs and Growth Factors: An Alliance Propelling Tumor Progression.

  • Laparoscopic versus open liver resection for metastatic colorectal cancer

    Authors: Nachmany I., Pencovich N., Zohar N., Ben-Yehuda A., Binyamin C., Goykhman Y., Lubezky N., Nakache R. & Klausner J. M. (2015), EJSO. 41, 12, p. 1615-1620
  • mRNA-transfected Dendritic Cells Expressing Polypeptides That Link MHC-I Presentation to Constitutive TLR4 Activation Confer Tumor Immunity

    Authors: Cafri G., Sharbi Yunger Y. A., Tzehoval E., Alteber Z., Gross T., Vadai E., Margalit A., Gross G. & Eisenbach L. (2015), Molecular Therapy. 23, 8, p. 1391-1400
  • Haploidentical hematopoietic stem cell transplantation: State of art

    Authors: Reisner Y., Aversa F. & Martelli M. (2015), Bone Marrow Transplantation. 50, p. S1-S5
  • Sonicated Protein Fractions of Mycoplasma hyopneumoniae Induce Inflammatory Responses and Differential Gene Expression in a Murine Alveolar Macrophage Cell Line

    Authors: Damte D., Lee S., Birhanu B. T., Suh J. & Park S. (2015), Journal of Microbiology and Biotechnology. 25, 12, p. 2153-2159
  • Tumor Suppressor Activity of Klotho in Breast Cancer is Revealed by Structure-function Analysis.

  • Tumor-specific expression and detection of a CEST reporter gene

    Authors: Minn I., Bar-Shir A., Yarlagadda K., Bulte J. W., Fisher P. B., Wang H., Gilad A. A. & Pomper M. G. (2015), Magnetic Resonance in Medicine. 74, 2, p. 544-549
  • EGF induces microRNAs that target suppressors of cell migration: MiR-15b targets MTSS1 in breast cancer

    Authors: Kedmi M., Ben Chetrit C. N., Koerner C., Mancini M., Ben-Moshe N. B., Lauriola M., Lavi S., Biagioni F., Carvalho S., Cohen-Dvashi H., Schmitt F., Wiemann S., Blandino G. & Yarden Y. (2015), Science Signaling. 8, 368, p. ra29
  • Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

    Authors: Golani O., Naffar-Abu-Amara S. & Geiger B. (2015), The Journal of Clinical Investigation. 125, 4, p. 1648-1664
  • Modeling and Predicting Optimal Treatment Scheduling Between the Antiangiogenic Drug Sunitinib and Irinotecan in Preclinical Settings

    Authors: Wilson S., Tod M., Ouerdani A., Emde A., Yarden Y., Berkane A. A., Kassour S., Wei M. X., Freyer G., You B., Grenier E. & Ribba B. (2015), CPT: Pharmacometrics and Systems Pharmacology. 4, 12, p. 720-727
  • Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma

    Authors: Kurscheid S., Bady P., Sciuscio D., Samarzija I., Shay T., Vassallo I., Criekinge W. V., Daniel R. T., van den Bent d. B. M. J., Marosi C., Weller M., Mason W. P., Domany E., Stupp R., Delorenzi M. & Hegi M. E. (2015), Genome Biology. 16, 1, 16
  • Tumor-associated and disease-associated autoantibody repertoires in healthy colostrum and maternal and newborn cord sera

    Authors: Madi A., Bransburg-Zabary S., Maayan-Metzger A., Dar G., Ben-Jacob E. & Cohen I. R. (2015), Journal of Immunology. 194, 11, p. 5272-5281
  • Recurrent inactivating RASA2 mutations in melanoma

    Authors: Arafeh R., Qutob N., Emmanuel R., Keren-Paz A., Madore J., Elkahloun A., Wilmott J. S., Gartner J. J., Di Pizio A., Winograd-Katz S., Sindiri S., Rotkopf R., Dutton-Regester K., Johansson P., Pritchard A. L., Waddell N., Hill V. K., Lin J. C., Hevroni Y., Rosenberg S. A., Khan J., Ben-Dor S., Niv M. Y., Ulitsky I., Mann G. J., Scolyer R. A., Hayward N. K. & Samuels Y. (2015), Nature Genetics. 47, 12, p. 1408-1410
  • Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

    Authors: Ben Chetrit C. N., Chetrit D., Russell R., Koerner C., Mancini M., Abdul-Hai A., Itkin T., Carvalho S., Cohen-Dvashi H., Koestler W. J., Shukla K., Lindzen M., Kedmi M., Lauriola M., Shulman Z., Barr H., Seger D., Ferraro D. A., Pareja F., Gil-Henn H., Lapidot T., Alon R., Milanezi F., Symons M., Ben Hamo H. R., Efroni S., Schmitt F., Wiemann S., Caldas C., Ehrlich M. & Yarden Y. (2015), Science Signaling. 8, 360, ra7
  • The BH3-only protein BID impairs the p38-mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice

    Authors: Orlik J., Schüngel S., Buitrago-Molina L. E., Marhenke S., Geffers R., Endig J., Lobschat K., Rössler S., Goeppert B., Manns M. P., Gross A. & Vogel A. (2015), Hepatology. 62, 3, p. 816-828
  • Hepatitis B virus induces RNR-R2 expression via DNA damage response activation

    Authors: Ricardo Lax L. I., Ramanan V., Michailidis E., Shamia T., Reuven N., Rice C., Shlomai A. & Shaul Y. (2015), Journal of Hepatology. 63, 4, p. 789-796
  • Extracellular matrix regulation of ErbB3 in a subset of wild-type BRAF/NRAS melanoma

    Authors: Rosenbaum S., Capparelli C., Berman-Booty L., Gaborit N., Zhan T., Davies M., Setiady Y., Yarden Y. & Aplin A. (2015),
  • Pathway-based personalized analysis of breast cancer expression data

    Authors: Livshits A., Git A., Fuks G., Caldas C. & Domany E. (2015), Molecular Oncology. 9, 7, p. 1471-1483
  • Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression

    Authors: Cohen-Dvashi H., Ben Chetrit C. N., Russell R., Carvalho S., Lauriola M., Nisani S., Mancini M., Nataraj N., Kedmi M., Roth L., Koestler W., Zeisel A., Yitzhaky A., Zylberg J., Tarcic G., Eilam R., Wigelman Y., Will R., Lavi S., Porat Z., Wiemann S., Ricardo S., Schmitt F., Caldas C. & Yarden Y. (2015), EMBO Molecular Medicine. 7, 3, p. 299-314
  • P53 orchestrates between normal differentiation and cancer

    Authors: Rivlin N., Koifman G. & Rotter V. (2015), Seminars in Cancer Biology. 32, p. 10-17
  • ErbB3-ErbB2 complexes as a therapeutic target in a subset of wild-type BRAF/NRAS cutaneous melanomas

    Authors: Capparelli C., Rosenbaum S., Berman-Booty L. D., Salhi A., Gaborit N., Zhan T., Chervoneva I., Roszik J., Woodman S. E., Davies M. A., Setiady Y. Y., Osman I., Yarden Y. & Aplin A. E. (2015), Cancer Research. 75, 17, p. 3554-3567