All Scientific Activities

Revealing modification in cell structure

The green, red and blue seen here is the result of an immunostaining technique that reveals modification in cell structure in response to growth factor stimulation. The treatment of a non-cancerous epithelial breast cell line with a growth factor induced motility, leading to the modification and reorganization of the cytoskeleton. This technique, which reveals the presence and position of actin (green), tubulin (red) and the cell nucleus (blue) in non-cancerous cells, enables the visualization of pathways and conformational changes associated with cancer. 

The cells were grown on matrix coated glass. The staining was performed through the use of probes for the nucleus (DAPI) and actin (phalloidin),and, for tubulin, with an immunostaining antibody.  The images were taken using a spinning disk microscope.

Image curtesy of Lee Roth, Prof. Yosef Yarden lab

Developing an innovative method

Prof. Tsvee Lapidot of the Department of Immunologyis working with a colleague at MD Anderson Cancer Center in Houston, seeking to develop an innovative method for improved engraftment of blood stem cells, which, it is hoped, will accelerate the recovery of patients with high-risk hematologic diseases who are undergoing blood cell transplantation.

Targeting p53 mutations

Prof. Varda Rotter of the Department of Molecular Cell Biology and colleagues at Tel Aviv Sourasky Medical Center are looking into novel methods to target p53 mutations in glioblastoma, a particularly deadly brain cancer that is in great need of effective medical treatments.