• The Metabolomic-Gut-Clinical Axis of Mankai Plant-Derived Dietary Polyphenols

    Authors: Yaskolka Meir A., Tuohy K., von Bergen M., Krajmalnik-Brown R., Heinig U., Zelicha H., Tsaban G., Rinott E., Kaplan A., Aharoni A., Zeibich L., Chang D., Dirks B., Diotallevi C., Arapitsas P., Vrhovsek U., Ceglarek U., Haange S., Rolle-Kampczyk U., Engelmann B., Lapidot M., Colt M., Sun Q. & Shai I. (2021), Nutrients. 13, 6, 1866
  • Phenylpropanoid Metabolism in Astringent and Nonastringent Persimmon (Diospyros kaki) Cultivars Determines Sensitivity to Alternaria Infection

    Authors: Yadav A., Fennec A., Davidovich-Rikanati R., Meir S., Kochanek B., Lewinsohn E., Aharoni A., Alkan N. & Friedman H. (2021), Journal of Agricultural and Food Chemistry. 69, 20, p. 5628-5637
  • NQO1 Binds and Supports SIRT1 Function

    Authors: Tsvetkov P., Adler J., Strobelt R., Adamovich Y., Asher G., Reuven N. & Shaul Y. (2021), Frontiers in Pharmacology. 12, 671929
  • Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance

    Authors: Povolotsky T. L., Keren-Paz A. & Kolodkin-Gal I. (2020),
  • A hairy-root transformation protocol for Trigonella foenum-graecum L. as a tool for metabolic engineering and specialised metabolite pathway elucidation

    Authors: Garagounis C., Beritza K., Georgopoulou M., Sonawane P., Haralampidis K., Goossens A., Aharoni A. & Papadopoulou K. K. (2020), Plant Physiology and Biochemistry. 154, p. 451-462
  • High mass resolution, spatial metabolite mapping enhances the current plant gene and pathway discovery toolbox

    Authors: Dong Y., Sonawane P., Cohen H., Polturak G., Feldberg L., Avivi S. H., Rogachev I. & Aharoni A. (2020), New Phytologist. 228, 6, p. 1986-2002
  • Metabolomics should be deployed in the identification and characterization of gene-edited crops

    Authors: Fraser P. D., Aharoni A., Hall R. D., Huang S., Giovannoni J. J., Sonnewald U. & Fernie A. R. (2020), Plant Journal. 102, 5, p. 897-902
  • Comparative Metabolomics and Molecular Phylogenetics of Melon (Cucumis melo, Cucurbitaceae) Biodiversity

    Authors: Moing A., Allwood J. W., Aharoni A., Baker J., Beale M. H., Ben-Dor S., Biais B., Brigante F., Burger Y., Deborde C., Erban A., Faigenboim A., Gur A., Goodacre R., Hansen T. H., Jacob D., Katzir N., Kopka J., Lewinsohn E., Maucourt M., Meir S., Miller S., Mumm R., Oren E., Paris H. S., Rogachev I., Rolin D., Saar U., Schjoerring J. K., Tadmor Y., Tzuri G., de Vos R. C. H., Ward J. L., Yeselson E., Hall R. D. & Schaffer A. A. (2020), Metabolites. 10, 3, 121
  • Targeting Metabolic Plasticity and flexibility Dynamics for Cancer Therapy

    Authors: Fendt S., Frezza C. & Erez A. (2020), Cancer Discovery. 10, 12, p. 1797-1807
  • Analysis of wild tomato introgression lines elucidates the genetic basis of transcriptome and metabolome variation underlying fruit traits and pathogen response

    Authors: Szymanski J., Bocobza S., Panda S., Sonawane P., Cardenas P. D., Lashbrooke J., Kamble A., Shahaf N., Meir S., Bovy A., Beekwilder J., Tikunov Y., Romero de la Fuente I., Zamir D., Rogachev I. & Aharoni A. (2020), Nature Genetics. 52, p. 1111-1121
  • Tissue-specific organic acid metabolism in reproductive and non-reproductive parts of the fig fruit is partially induced by pollination

    Authors: Lama K., Peer R., Shlizerman L., Meir S., Doron-Faigenboim A., Sadka A., Aharoni A. & Flaishman M. A. (2020), Physiologia Plantarum. 168, 1, p. 133-147
  • Advances and future directions in betalain metabolic engineering

    Authors: Polturak G. & Aharoni A. (2019), The New Phytologist. 224, 4, p. 1472-1478
  • Miso: An R Package for Multiple Isotope Labeling Assisted Metabolomics Data Analysis

    Authors: Dong Y., Feldberg L. & Aharoni A. (2019), Bioinformatics. 35, 18, p. 3524-3526
  • The Plant Host Induces Antibiotic Production To Select the Most-Beneficial Colonizers

    Authors: Ogran A., Yardeni E. H., Keren-Paz A., Bucher T., Jain R., Gilhar O. & Kolodkin-Gal I. (2019), Applied and Environmental Microbiology. 85, 13, UNSP e0051
  • In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids

    Authors: Schleyer G., Shahaf N., Ziv C., Dong Y., Meoded R. A., Helfrich E. J. N., Schatz D., Rosenwasser S., Rogachev I., Aharoni A., Piel J. & Vardi A. (2019), Nature Microbiology. 4, p. 527-538
  • Appropriate Thiamin Pyrophosphate Levels Are Required for Acclimation to Changes in Photoperiod

    Authors: Rosado-Souza L., Proost S., Moulin M., Bergmann S., Bocobza S. E., Aharoni A., Fitzpatrick T. B., Mutwil M., Fernie A. R. & Obata T. (2019), Plant Physiology. 180, 1, p. 185-197
  • Physiological and Molecular Dissection of Daily Variance in Exercise Capacity

    Authors: Ezagouri S., Zwighaft Z., Sobel J., Baillieul S., Doutreleau S., Ladeuix B., Golik M., Verges S. & Asher G. (2019), Cell Metabolism. 30, 1, p. 78-91.e4
  • ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus

    Authors: , Lerner S., Eilam R., Kuperman Y., Tsoory M., Brandis A., Segal M., Chen A. & Erez A. (2019), Cell Reports. 29, 8, p. 2144-2153.e7
  • Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy

    Authors: Lonetto G., Koifman G., Silberman A., Attery A., Solomon H., Levin-Zaidman S., Goldfinger N., Porat Z., Erez A. & Rotter V. (2019), Cell Death and Differentiation. 26, 9, p. 1566-1581
  • Transcriptome and Metabolic Profiling Provides Insights into Betalain Biosynthesis and Evolution in Mirabilis jalapa

    Authors: Polturak G., Heinig U., Grossman N., Battat M., Leshkowitz D., Malitsky S., Rogachev I. & Aharoni A. (2018), Molecular Plant. 11, 1, p. 189-204
  • Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

    Authors: Lee J. S., Adler L., Karathia H., Carmel N., Rabinovich S., Auslander N., Keshet R., Stettner N., Silberman A., Agemy L., Helbling D., Eilam R., Sun Q., Brandis A., Malitsky S., Itkin M., Weiss H., Pinto S., Kalaora S., Levy R., Barnea E., Admon A., Dimmock D., Stern-Ginossar N., Scherz A., Nagamani S. C. S., Unda M., Wilson D. M., Elhasid R., Carracedo A., Samuels Y., Hannenhalli S., Ruppin E. & Erez A. (2018), Cell. 174, 6, p. 1559-1570
  • "La Vie en Rose'': Biosynthesis, Sources, and Applications of Betalain Pigments

    Authors: Polturak G. & Aharoni A. (2018), Molecular Plant. 11, 1, p. 7-22
  • A complete pipeline for generating a high-resolution LC-MS-Based reference mass spectra library

  • DLEMMA-MS-Imaging for Identification of Spatially Localized Metabolites and Metabolic Network Map Reconstruction

    Authors: Feldberg L., Dong Y., Heinig U., Rogachev I. & Aharoni A. (2018), Analytical Chemistry. 90, 17, p. 10231-10238
  • Rewiring urea cycle metabolism in cancer to support anabolism

    Authors: Keshet R., Szlosarek P., Carracedo A. & Erez A. (2018), Nature Reviews Cancer. 18, 10, p. 634-645
  • Arginine and the metabolic regulation of nitric oxide synthesis in cancer

    Authors: Keshet R. & Erez A. (2018), Disease Models & Mechanisms. 11, 8, dmm033332
  • Insights into Tissue-specific Specialized Metabolism in Tieguanyin Tea Cultivar by Untargeted Metabolomics

    Authors: Chen S., Lin J., Liu H., Gong Z., Wang X., Li M., Aharoni A., Yang Z. & Yu X. (2018), Molecules. 23, 7, 1817
  • Integration of plant metabolomics data with metabolic networks: Progresses and challenges

    Authors: Töpfer N., Seaver S. M. & Aharoni A. (2018), Plant Metabolomics. António C. (eds.). p. 297-310 (1Methods in Molecular Biology).
  • Metabolic Flexibility Underpins Growth Capabilities of the Fastest Growing Alga

    Authors: Treves H., Murik O., Kedem I., Eisenstadt D., Meir S., Rogachev I., Szymanski J., Keren N., Orf I., Tiburcio A. F., Alcazar R., Aharoni A., Kopka J. & Kaplan A. (2017), Current Biology. 27, 16, p. 2559-2567
  • Label-free deep shotgun proteomics reveals protein dynamics during tomato fruit tissues development

    Authors: Szymanski J., Levin Y., Savidor A., Breitel D., Chappell-Maor L., Heinig U., Toepfer N. & Aharoni A. (2017), Plant Journal. 90, 2, p. 396-417
  • The PhytoClust tool for metabolic gene clusters discovery in plant genomes

    Authors: Topfer N., Fuchs L. & Aharoni A. (2017), Nucleic Acids Research. 45, 12, p. 7049-7063
  • Dynamic metabolic reprogramming of steroidal glycol-alkaloid and phenylpropanoid biosynthesis may impart early blight resistance in wild tomato (Solanum arcanum Peralta)

    Authors: Shinde B. A., Dholakia B. B., Hussain K., Panda S., Meir S., Rogachev I., Aharoni A., Giri A. P. & Kamble A. C. (2017), Plant Molecular Biology. 95, p. 411-423
  • Assimilation of `omics' strategies to study the cuticle layer and suberin lamellae plants

    Authors: Cohen H., Szymanski J. & Aharoni A. (2017), Journal of Experimental Botany. 68, 19, p. 5389-5400
  • The WEIZMASS spectral library for high-confidence metabolite identification.

    Authors: Shahaf N., Rogachev I., Heinig U., Meir S., Malitsky S., Battat M., Wyner H., Zheng S., Wehrens R. & Aharoni A. (2016), Nature Communications. 7, 12423
  • A metabolic link between the urea cycle and cancer cell proliferation

    Authors: Nagamani S. C. S. & Erez A. (2016), Molecular & cellular oncology. 3, 2, 1127314
  • A Metabolic Gene Cluster in the Wheat W1 and the Barley Cer-cqu Loci Determines beta-Diketone Biosynthesis and Glaucousness

    Authors: Hen Avivi A. S., Savin O., Racovita R. C., Lee W., Adamski N. M., Malitsky S., Almekias-Siegl E., Levy M., Vautrin S., Berges H., Friedlander G., Kartvelishvily E., Ben-Zvi G., Alkan N., Uauy C., Kanyuka K., Jetter R., Distelfeld A. & Aharoni A. (2016), Plant Cell. 28, 6, p. 1440-1460
  • An efficient method for medium throughput screening of cuticular wax composition in different plant species

    Authors: Fernandez-Moreno J., Malitsky S., Lashbrooke J., Biswal A., Racovita R., Mellerowicz E., Jetter R., Orzaez D., Aharoni A. & Granell A. (2016), Metabolomics. 12, 73
  • Circadian Clock Control of Liver Metabolic Functions

    Authors: Reinke H. & Asher G. (2016), Gastroenterology. 150, 3, p. 574-580
  • Altered metabolite accumulation in tomato fruits by coexpressing a feedback-insensitive AroG and the PhODO1 MYB-type transcription factor

    Authors: Xie Q., Liu Z., Meir S., Rogachev I., Aharoni A., Klee H. J. & Galili G. (2016), Plant Biotechnology Journal. 14, 12, p. 2300-2309
  • Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga.

    Authors: Ziv C., Malitsky S., Othman A., Ben-Dor S., Wei Y., Zheng S., Aharoni A., Hornemann T. & Vardi A. (2016), Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. E1907-E1916
  • Manipulating duckweed through genome duplication

    Authors: Vunsh R., Heinig U., Malitsky S., Aharoni A., Avidov A., Lerner A. & Edelman M. (2015), Plant Biology. 17, s1, p. 115-119
  • Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

    Authors: Rabinovich S., Adler L., Yizhak K., Sarver A., Silberman A., Agron S., Stettner N., Sun Q., Brandis A., Helbling D., Korman S., Itzkovitz S., Dimmock D., Ulitsky I., Nagamani S. C. S., Ruppin E. & Erez A. (2015), Nature. 527, 7578, p. 379-383
  • The bitter side of the nightshades: Genomics drives discovery in Solanaceae steroidal alkaloid metabolism

    Authors: Cárdenas P. D., Sonawane P. D., Heinig U., Bocobza S. E., Burdman S. & Aharoni A. (2015), Phytochemistry. 113, p. 24-32
  • Metabolic dysregulation in monogenic disorders and cancer - finding method in madness.

    Authors: Erez A. & DeBerardinis R. J. (2015), Nature reviews. Cancer. 15, 7, p. 440-8, 26084394
  • Time for Food: The Intimate Interplay between Nutrition, Metabolism, and the Circadian Clock

    Authors: Asher G. & Sassone-Corsi P. (2015), Cell. 161, 1, p. 84-92
  • Artificial Sweeteners Induce Glucose Intolerance by Altering the Gut Microbiota: Editorial comment

    Authors: Suez J., Korem T., Zeevi D., Zilberman-Schapira G., Thaiss C. A., Maza O., Israeli D., Zmora N., Gilad S., Weinberger A., Kuperman Y., Harmelin A., Kolodkin-Gal I., Shapiro H., Halpern Z., Segal E. & Elinav E. (2015), Obstetrical & Gynecological Survey. 70, 1, p. 31-32
  • Artificial sweeteners induce glucose intolerance by altering the gut microbiota

    Authors: Suez J., Korem T., Zeevi D., Zilberman-Schapira G., Thaiss C. A., Maza O., Israeli D., Zmora N., Gilad S., Weinberger A., Kuperman Y., Harmelin A., Kolodkin-Gal I., Shapiro H., Halpern Z., Segal E. & Elinav E. (2014), Nature. 514, 7521, p. 181-186
  • An O-methyltransferase modifies accumulation of methylated anthocyanins in seedlings of tomato

    Authors: Roldan M. V. G., Outchkourov N., van Houwelingen H. A., Lammers M., de la Fuente l. F. I. R., Ziklo N., Aharoni A., Hall R. D. & Beekwilder J. (2014), Plant Journal. 80, 4, p. 695-708
  • Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides

    Authors: Adamovich Y., Rousso Noori L., Zwighaft Z., Neufeld - Cohen A., Golik M., Kraut-Cohen J., Wang M., Han X. & Asher G. (2014), Cell Metabolism. 19, 2, p. 319-330
  • Small molecules that interact with RNA: riboswitch-based gene control and its involvement in metabolic regulation in plants and algae

    Authors: Bocobza S. E. & Aharoni A. (2014), Plant Journal. 79, 4, p. 693-703
  • Rewiring Host Lipid Metabolism by Large Viruses Determines the Fate of Emiliania huxleyi, a Bloom-Forming Alga in the Ocean

    Authors: Rosenwasser S., Mausz M. A., Schatz D., Sheyn U., Malitsky S., Aharoni A., Weinstock E., Tzfadia O., Ben-Dor S., Feldmesser E., Pohnert G. & Vardi A. (2014), Plant Cell. 26, 6, p. 2689-2707
  • Argininosuccinic aciduria: from a monogenic to a complex disorder

    Authors: Erez A. (2013), Genetics in Medicine. 15, 4, p. 251-257
  • The challenges of cellular compartmentalization in plant metabolic engineering

    Authors: Heinig U., Gutensohn M., Dudareva N. & Aharoni A. (2013), Current Opinion in Biotechnology. 24, 2, p. 239-246
  • High-resolution metabolic mapping of cell types in plant roots

    Authors: Moussaieff A., Rogachev I., Brodsky L., Malitsky S., Toal T. W., Belcher H., Yativ M., Brady S. M., Benfey P. N. & Aharoni A. (2013), Proceedings of the National Academy of Sciences of the United States of America. 110, 13, p. E1232-E1241
  • Discovery of New Modules in Metabolic Biology Using ChemoMetabolomics

    Authors: Bocobza S., Willmitzer L., Raikhel N. V. & Aharoni A. (2012), Plant Physiology. 160, 3, p. 1160-1163
  • UPLC-MS-based metabolite analysis in tomato

    Authors: Rogachev I. & Aharoni A. (2012), Plant Metabolomics. p. 129-144 (1Methods in Molecular Biology).
  • Identification of novel lignans in the whole grain rye bran by non-targeted LC-MS metabolite profiling

    Authors: Hanhineva K., Rogachev I., Aura A., Aharoni A., Poutanen K. & Mykkanen H. (2012), Metabolomics. 8, 3, p. 399-409
  • Co-mapping studies of QTLs for fruit acidity and candidate genes of organic acid metabolism and proton transport in sweet melon (Cucumis melo L.)

    Authors: Cohen S., Tzuri G., Harel-Beja R., Itkin M., Portnoy V., Sa'ar U., Lev S., Yeselson L., Petrikov M., Rogachev I., Aharoni A., Ophir R., Tadmor Y., Lewinsohn E., Burger Y., Katzir N. & Schaffer A. A. (2012), Theoretical And Applied Genetics. 125, 2, p. 343-353
  • Reconstruction of Arabidopsis metabolic network models accounting for subcellular compartmentalization and tissue-specificity

    Authors: Mintz-Oron S., Meir S., Malitsky S., Ruppin E., Aharoni A. & Shlomi T. (2012), Proceedings of the National Academy of Sciences of the United States of America. 109, 1, p. 339-344
  • Expression of a bacterial feedback-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway in Arabidopsis elucidates potential metabolic bottlenecks between primary and secondary metabolism

    Authors: Tzin V., Malitsky S., Ben Zvi Z. M. M., Bedair M., Sumner L., Aharoni A. & Galili G. (2012), New Phytologist. 194, 2, p. 430-439
  • KaPPA-View4: a metabolic pathway database for representation and analysis of correlation networks of gene co-expression and metabolite co-accumulation and omics data

    Authors: Sakurai N., Ara T., Ogata Y., Sano R., Ohno T., Sugiyama K., Hiruta A., Yamazaki K., Yano K., Aoki K., Aharoni A., Hamada K., Yokoyama K., Kawamura S., Otsuka H., Tokimatsu T., Kanehisa M., Suzuki H. & Saito K. (2011), Nucleic Acids Research. 39, p. D677-D684
  • JA-Ile signalling in Solanum nigrum is not required for defence responses in nature

    Authors: Vandoorn A., Bonaventure G., Rogachev I., Aharoni A. & Baldwin I. T. (2011), Plant Cell And Environment. 34, 12, p. 2159-2171
  • Extensive metabolic cross-talk in melon fruit revealed by spatial and developmental combinatorial metabolomics

    Authors: Moing A., Aharoni A., Biais B., Rogachev I., Meir S., Brodsky L., Allwood J. W., Erban A., Dunn W. B., Kay L., de Koning K. S., de Vos V. R. C. H., Jonker H., Mumm R., Deborde C., Maucourt M., Bernillon S., Gibon Y. & Hansen T. H. (2011), New Phytologist. 190, 3, p. 683-696
  • Metabolic engineering of the plant primary-secondary metabolism interface

    Authors: Aharoni A. & Galili G. (2011), Current Opinion in Biotechnology. 22, 2, p. 239-244
  • Tissue- and Cell-Type Specific Transcriptome Profiling of Expanding Tomato Fruit Provides Insights into Metabolic and Regulatory Specialization and Cuticle Formation

    Authors: Matas A. J., Yeats T. H., Buda G. J., Zheng Y., Chatterjee S., Tohge T., Ponnala L., Adato A., Aharoni A., Stark R., Fernie A. R., Fei Z., Giovannoni J. J. & Rose J. K. C. (2011), Plant Cell. 23, 11, p. 3893-3910
  • Evaluation of Peak Picking Quality in LC-MS Metabolomics Data

    Authors: Brodsky L., Moussaieff A., Shahaf N., Aharoni A. & Rogachev I. (2010), Analytical Chemistry. 82, 22, p. 9177-9187
  • Metabolic networking in Brunfelsia calycina petals after flower opening

    Authors: Bar-Akiva A., Ovadia R., Rogachev I., Bar-Or C., Bar E., Freiman Z., Nissim-Levi A., Gollop N., Lewinsohn E., Aharoni A., Weiss D., Koltai H. & Oren-Shamir M. (2010), Journal of Experimental Botany. 61, 5, p. 1393-1403
  • Metabolomics in Fruit Development

    Authors: Hanhineva K. & Aharoni A. (2010),