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All Publications

  • Incorporation of nitrogen in antinutritional Solanum alkaloid biosynthesis

    Authors: Grzech D., Smit S. J., Alam R. M., Boccia M., Nakamura Y., Hong B., Barbole R., Heinicke S., Kunert M., Seibt W., Grabe V., Caputi L., Lichman B. R., OConnor S. E., Aharoni A. & Sonawane P. D. (2024), Nature Chemical Biology.

  • ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response

    Authors: Lim L. Q. J., Adler L., Hajaj E., Soria L. R., Perry R. B. T., Darzi N., Brody R., Furth N., Lichtenstein M., Bab-Dinitz E., Porat Z., Melman T., Brandis A., Aylon Y., Ben-Dor S., Orr I., Pri-Or A., Seger R., Shaul Y., Ruppin E., Oren M., Perez M., Meier J., Brunetti-Pierri N., Shema E., Ulitsky I., Erez A., Malitsky S. & Itkin M. (2024), Nature metabolism. 6, 7, p. 1294-1309

  • Embracing cancer complexity: Hallmarks of systemic disease

    Authors: Swanton C., Bernard E., Abbosh C., André F., Auwerx J., Balmain A., Bar-Sagi D., Bernards R., Bullman S., DeGregori J., Elliott C., Erez A., Evan G., Febbraio M. A., Hidalgo A., Jamal-Hanjani M., Joyce J. A., Kaiser M., Lamia K., Locasale J. W., Loi S., Malanchi I., Merad M., Musgrave K., Patel K. J., Quezada S., Wargo J. A., Weeraratna A., White E., Winkler F., Wood J. N., Vousden K. H. & Hanahan D. (2024), Cell. 187, 7, p. 1589-1616

  • From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments

    Authors: Hajaj E., Pozzi S. & Erez A. (2024), Cold Spring Harbor perspectives in medicine. 14, 4, a041538

  • MetaboReport: from metabolomics data analysis to comprehensive reporting

    Authors: Dong Y. & Malitsky S. (2024), Bioinformatics. 40, 6, btae373

  • Programming a Ferroptosis-to-Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy

    Authors: Vinik Y., Maimon A., Dubey V., Raj H., Abramovitch I., Malitsky S., Itkin M., Ma'ayan A., Westermann F., Gottlieb E., Ruppin E. & Lev S. (2024), Advanced Science. 11, 17, 2307263

  • Algal methylated compounds shorten the lag phase of Phaeobacter inhibens bacteria

    Authors: Sperfeld M., Narváez-Barragán D. A., Malitsky S., Frydman V., Yuda L., Rocha J. & Segev E. (2024), Nature Microbiology. 9, 8, p. 2006-2021

  • Metabolic inputs in the probiotic bacterium Lacticaseibacillus rhamnosus contribute to cell-wall remodeling and increased fitness

    Authors: Suissa R., Olender T., Malitsky S., Golani O., Turjeman S., Koren O., Meijler M. M. & Kolodkin-Gal I. (2023), npj Biofilms and Microbiomes. 9, 1, 71

  • Beyond circadian rhythms: Emerging roles of ultradian rhythms in control of liver functions

    Authors: Asher G. & Zhu B. (2023), Hepatology. 77, 3, p. 1022-1035

  • N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimers disease mouse model

    Authors: Suzzi S., Croese T., Ravid A., Gold O., Clark A. R., Medina S., Kitsberg D., Adam M., Vernon K. A., Kohnert E., Shapira I., Malitsky S., Itkin M., Brandis A., Mehlman T., Salame T. M., Colaiuta S. P., Cahalon L., Slyper M., Greka A., Habib N. & Schwartz M. (2023), Nature Communications. 14, 1, 1293

  • High-energy demand and nutrient exhaustion in MTCH2 knockout cells

    Authors: Chourasia S., Petucci C., Wang H., Han X., Sivan E., Brandis A., Mehlman T., Malitsky S., Itkin M., Rotkopf R., Regev L., Zaltsman Y. & Gross A. (2023), BioRxiv.

  • Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage

    Authors: Bigelman E., Pasmanik-Chor M., Dassa B., Itkin M., Malitsky S., Dorot O., Pichinuk E., Kleinberg Y., Keren G. & Entin-Meer M. (2023), PLoS ONE. 18, 8, e0275550

  • Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes

    Authors: Nobs S. P., Kolodziejczyk A. A., Adler L., Horesh N., Botscharnikow C., Herzog E., Mohapatra G., Hejndorf S., Hodgetts R. J., Spivak I., Schorr L., Fluhr L., Kviatcovsky D., Zacharia A., Njuki S., Barasch D., Stettner N., Dori-Bachash M., Harmelin A., Brandis A., Mehlman T., Erez A., He Y., Ferrini S., Puschhof J., Shapiro H., Kopf M., Moussaieff A., Abdeen S. K. & Elinav E. (2023), Nature. 624, 7992, p. 645-652

  • On the Origins of Enzymes: Phosphate-Binding Polypeptides Mediate Phosphoryl Transfer to Synthesize Adenosine Triphosphate

    Authors: Vyas P., Malitsky S., Itkin M. & Tawfik D. S. (2023), Journal of the American Chemical Society. 145, 15, p. 8344-8354

  • Plant and microbial sciences as key drivers in the development of metabolomics research

    Authors: Aharoni A., Goodacre R. & Fernie A. R. (2023), Proceedings of the National Academy of Sciences - PNAS. 120, 12, e221738312

  • Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology

    Authors: Bolshette N., Ibrahim H., Reinke H. & Asher G. (2023), Nature Reviews Gastroenterology and Hepatology. 20, 11, p. 695-707

  • 2-NBDG Uptake in Gossypium hirsutum in vitro ovules: exploring tissue-specific accumulation and its impact on hexokinase-mediated glycolysis regulation

    Authors: Shamshoum M., Kuperman O. A., Shadmi S. K., Itkin M., Malitsky S. & Natalio F. (2023), Frontiers in Plant Science. 14, 1242150

  • Reduction in metabolic noise reveals rejuvenation following transient severe caloric restriction

    Authors: Levkovich G., Bendikov-Bar I., Malitsky S., Itkin M., Rusal M., Lokshtanov D., Shinder D. & Sagi D. (2023), GeroScience. 46, 2, p. 2343-2358

  • Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis

    Authors: Goldman O., Adler L. N., Hajaj E., Croese T., Darzi N., Galai S., Tishler H., Ariav Y., Lavie D., Fellus-Alyagor L., Oren R., Kuznetsov Y., David E., Jaschek R., Stossel C., Singer O., Malitsky S., Barak R., Seger R., Erez N., Amit I., Tanay A., Saada A., Golan T., Rubinek T., Sang Lee J., Ben-Shachar S., Wolf I. & Erez A. (2023), Cancer Discovery. 13, 7, p. 1616-1635

  • Lipid biomarkers for algal resistance to viral infection in the ocean

    Authors: Schleyer G., Kuhlisch C., Ziv C., Ben-Dorb S., Malitsky S., Schatz D. & Vardi A. (2023), Proceedings of the National Academy of Sciences of the United States of America. 120, 27, e221712112

  • A BAHD-type acyltransferase concludes the biosynthetic pathway of non-bitter glycoalkaloids in ripe tomato fruit

    Authors: Sonawane P. D., Gharat S. A., Jozwiak A., Barbole R., Heinicke S., Almekias-Siegl E., Meir S., Rogachev I., Connor S. E., Giri A. P. & Aharoni A. (2023), Nature Communications. 14, 4540

  • Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

    Authors: Sciacovelli M., Dugourd A., Jimenez L. V., Yang M., Nikitopoulou E., Costa A. S. H., Tronci L., Caraffini V., Rodrigues P., Schmidt C., Ryan D. G., Young T., Zecchini V. R., Rossi S. H., Massie C., Lohoff C., Masid M., Hatzimanikatis V., Kuppe C., Kramann R., Von Kriegsheim A., Gnanapragasam V., Warren A. Y., Stewart G. D., Erez A., Vanharanta S., Saez-Rodriguez J. & Frezza C. (2022), Nature Communications. 13, 1, 7830

  • Let's Connect Nature with Hypothesis-Based Experimentation and Explore Life in Context

    Authors: Negin B. & Aharoni A. (2022), The Plant journal : for cell and molecular biology. p. na-na

  • Metabolic diversity in a collection of wild and cultivated Brassica rapa subspecies

    Authors: Zheng S., Szymański J., Shahaf N., Malitsky S., Meir S., Wang X., Aharoni A. & Rogachev I. (2022), Frontiers in Molecular Biosciences. 9, 953189

  • Circadian clocks' interactions with oxygen sensing and signalling

    Authors: Adamovich Y., Dandavate V. & Asher G. (2022), Acta physiologica (Oxford, England). 234, 2, e13770

  • Steroidal alkaloids defence metabolism and plant growth are modulated by the joint action of gibberellin and jasmonate signalling

    Authors: Panda S., Jozwiak A., Sonawane P. D., Szymanski J., Kazachkova Y., Vainer A., Kilambi H. V., AlmekiasSiegl E., Dikaya V., Bocobza S., Shohat H., Meir S., Wizler G., Giri A. P., Schuurink R., Weiss D., Yasuor H., Kamble A. & Aharoni A. (2022), NEW PHYTOLOGIST. 233, 3, p. 1220-1237

  • Uncovering Pathways Highly Correlated to NUE through a Combined Metabolomics and Transcriptomics Approach in Eggplant

    Authors: Mauceri A., Aci M. M., Toppino L., Panda S., Meir S., Mercati F., Araniti F., Lupini A., Panuccio M. R., Rotino G. L., Aharoni A., Abenavoli M. R. & Sunseri F. (2022), Plants (Basel). 11, 5, 700

  • 2-Oxoglutarate-Dependent Dioxygenases Drive Expansion of Steroidal Alkaloid Structural Diversity in the Genus Solanum

    Authors: Sonawane P. D., Jozwiak A., Barbole R., Panda S., Abebie B., Kazachkova Y., Gharat S. A., Ramot O., Unger T., Wizler G., Meir S., Rogachev I., Doron-Faigenboim A., Petreikov M., Schaffer A., Giri A. P., Scherf T. & Aharoni A. (2022), The New Phytologist. 234, 4, p. 1394-1410

  • Enhanced proteostasis, lipid remodeling, and nitrogen remobilization define barley flag leaf senescence

    Authors: Cohen M., Hertweck K., Itkin M., Malitsky S., Dassa B., Fischer A. M. & Fluhr R. (2022), Journal of Experimental Botany. 73, 19, p. 6816-6837, erac329

  • The metabolic and proteomic repertoires of periderm tissue in skin of the reticulated Sikkim cucumber fruit

    Authors: Arya G. C., Dong Y., Heinig U., Shahaf N., Kazachkova Y., Aviv-Sharon E., Nomberg G., Marinov O., Manasherova E., Aharoni A. & Cohen H. (2022), Horticulture Research. 9, uhac092

  • Plant-microbe interactions in the rhizosphere via a circular metabolic economy

    Authors: Korenblum E., Massalha H. & Aharoni A. (2022), The Plant cell. 34, 9, p. 3168-3182, koac163

  • Editorial overview: Plant metabolism without a border: The interface of primary and specialised metabolism

    Authors: Aharoni A. & Maeda H. A. (2022), Current Opinion in Plant Biology. 69, 102296

  • Transcriptomics reveal new insights into molecular regulation of nitrogen use efficiency in Solanum melongena

    Authors: Mauceri A., Abenavoli M. R., Toppino L., Panda S., Mercati F., Aci M. M., Aharoni A., Sunseri F., Rotino G. L. & Lupini A. (2021), Journal of Experimental Botany. 72, 12, p. 4237-4253

  • Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

    Authors: Alseekh S., Aharoni A., Brotman Y., Contrepois K., D'Auria J., Ewald J., Ewald J. C., Fraser P. D., Giavalisco P., Hall R. D., Heinemann M., Link H., Luo J., Neumann S., Nielsen J. B., de Souza L. P., Saito K., Sauer U., Schroeder F. C., Schuster S., Siuzdak G., Skirycz A., Sumner L. W., Snyder M. P., Tang H., Tohge T., Wang Y., Wen W., Wu S., Xu G., Zamboni N. & Fernie A. R. (2021), Nature Methods. 18, 7, p. 747-756

  • Inhibition of gibberellin accumulation by water deficiency promotes fast and longterm drought avoidance responses in tomato

    Authors: Shohat H., Cheriker H., Kilambi H. V., Illouz Eliaz N., Blum S., Amsellem Z., Tarkowská D., Aharoni A., Eshed Y. & Weiss D. (2021), The New Phytologist. 232, 5, p. 1985-1998

  • Clock proteins and training modify exercise capacity in a daytime-dependent manner

    Authors: Adamovich Y., Dandavate V., Ezagouri S., Manella G., Zwighaft Z., Sobel J., Kuperman Y., Golik M., Auerbach A., Itkin M., Malitsky S. & Asher G. (2021), Proceedings of the National Academy of Sciences - PNAS. 118, 35, e210111511

  • The context-specific roles of urea cycle enzymes in tumorigenesis

    Authors: Hajaj E., Sciacovelli M., Frezza C. & Erez A. (2021), Molecular Cell. 81, 18, p. 3749-3759

  • Metabolomic Changes Are Predictive of Aging in Laying Hens

    Authors: Bendikov-Bar I., Malitsky S., Itkin M., Rusal M. & Sagi D. (2021), The journals of gerontology. Series A, Biological sciences and medical sciences. 76, 10, p. 1757-1768

  • Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response

    Authors: Ariav Y., Chng J. H., Christofk H. R., Ron-Harel N. & Erez A. (2021), Science advances. 7, 21, eabg6165

  • The metabolomic-gut-clinical axis of mankai plant-derived dietary polyphenols

    Authors: Yaskolka Meir A., Tuohy K., von Bergen M., Krajmalnik-Brown R., Heinig U., Zelicha H., Tsaban G., Rinott E., Kaplan A., Aharoni A., Zeibich L., Chang D., Dirks B., Diotallevi C., Arapitsas P., Vrhovsek U., Ceglarek U., Haange S., Rolle-Kampczyk U., Engelmann B., Lapidot M., Colt M., Sun Q. & Shai I. (2021), Nutrients. 13, 6, 1866

  • Metabolic decisions in development and diseasea Keystone Symposia report

    Authors: Cable J., Pourquié O., Wellen K. E., Finley L. W., Aulehla A., Gould A. P., Teleman A., Tu W. B., Garrett W. S., Miguel-Aliaga I., Perrimon N., Hooper L. V., Walhout A. J., Wei W., Alexandrov T., Erez A., Ralser M., Rabinowitz J. D., Hemalatha A., Gutiérrez-Pérez P., Chandel N. S., Rutter J., Locasale J. W., Landoni J. C. & Christofk H. (2021), Annals of the New York Academy of Sciences. 1506, 1, p. 55-73

  • Host succinate is an activation signal for Salmonella virulence during intracellular infection

    Authors: Rosenberg G., Yehezkel D., Hoffman D., Ciolli Mattioli C., Fremder M., Ben-Arosh H., Vainman L., Nissani N., Hen-Avivi S., Brenner S., Itkin M., Malitsky S., Ohana E., Ben-Moshe N. B. & Avraham R. (2021), Science. 371, 6527, p. 400-405

  • Characterization of the PRODUCTION of ANTHOCYANIN PIGMENT 1 Arabidopsis dominant mutant using DLEMMA dual isotope labeling approach

    Authors: Dong Y., Feldberg L., Rogachev I. & Aharoni A. (2021), Phytochemistry (Oxford). 186, 112740

  • ASL expression in ALDH1A1 + neurons in the substantia nigra metabolically contributes to neurodegenerative phenotype

    Authors: Lerner S., Eilam R., Adler L., Tsoory M., Brandis A. & Erez A. (2021), Human Genetics. 140, 10, p. 1471-1485

  • Catch-22 in specialized metabolism: balancing defense and growth

    Authors: Panda S., Kazachkova Y. & Aharoni A. (2021), Journal of Experimental Botany. 72, 17, p. 6027-6041

  • The GORKY glycoalkaloid transporter is indispensable for preventing tomato bitterness

    Authors: Kazachkova Y., Zemach I., Panda S., Bocobza S., Vainer A., Rogachev I., Dong Y., Ben-Dor S., Veres D., Kanstrup C., Lambertz S. K., Crocoll C., Hu Y., Shani E., Michaeli S., Nour-Eldin H. H., Zamir D. & Aharoni A. (2021), Nature Plants. 7, p. 468-480

  • Glycosylation of N-hydroxy-pipecolic acid equilibrates between systemic acquired resistance response and plant growth

    Authors: Cai J., Jozwiak A., Holoidovsky L., Meijler M. M., Meir S., Rogachev I. & Aharoni A. (2021), Molecular Plant. 14, 3, p. 440-455

  • Systemic Regulation of Host Energy and Oogenesis by Microbiome-Derived Mitochondrial Coenzymes

    Authors: Gnainsky Y., Zfanya N., Elgart M., Omri E., Brandis A., Mehlman T., Itkin M., Malitsky S., Adamski J. & Soen Y. (2021), Cell Reports. 34, 1, 108583

  • Ultradian rhythms of AKT phosphorylation and gene expression emerge in the absence of the circadian clock components Per1 and Per2

    Authors: Aviram R., Dandavate V., Manella G., Golik M. & Asher G. (2021), PLoS Biology. 19, 12, e3001492

  • Sugar-regulated susceptibility of tomato fruit to Colletotrichum and Penicillium requires differential mechanisms of pathogenicity and fruit responses

    Authors: Ziv C., Kumar D., Sela N., Itkin M., Malitsky S., Schaffer A. A. & Prusky D. B. (2020), Environmental Microbiology. 22, 7, p. 2870-2891

  • Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance

    Authors: Povolotsky T. L., Keren-Paz A. & Kolodkin-Gal I. (2020),

  • A hairy-root transformation protocol for Trigonella foenum-graecum L. as a tool for metabolic engineering and specialised metabolite pathway elucidation

    Authors: Garagounis C., Beritza K., Georgopoulou M., Sonawane P., Haralampidis K., Goossens A., Aharoni A. & Papadopoulou K. K. (2020), Plant Physiology and Biochemistry. 154, p. 451-462

  • Resilience to Freezing in the Vegetative Cells of the Microalga Lobosphaera incisa (Trebouxiophyceae, Chlorophyta)

    Authors: Kugler A., Kumari P., Kokabi K., Itkin M., Malitsky S. & Khozin-Goldberg I. (2020), Journal of Phycology. 56, 2, p. 334-345

  • High mass resolution, spatial metabolite mapping enhances the current plant gene and pathway discovery toolbox

    Authors: Dong Y., Sonawane P., Cohen H., Polturak G., Feldberg L., Avivi S. H., Rogachev I. & Aharoni A. (2020), New Phytologist. 228, 6, p. 1986-2002

  • Hijacking core metabolism: a new panache for the evolution of steroidal glycoalkaloids structural diversity

    Authors: Sonawane P. D., Jozwiak A., Panda S. & Aharoni A. (2020), Current Opinion in Plant Biology. 55, p. 118-128

  • Metabolomics should be deployed in the identification and characterization of gene-edited crops

    Authors: Fraser P. D., Aharoni A., Hall R. D., Huang S., Giovannoni J. J., Sonnewald U. & Fernie A. R. (2020), Plant Journal. 102, 5, p. 897-902

  • Comparative Metabolomics and Molecular Phylogenetics of Melon (Cucumis melo, Cucurbitaceae) Biodiversity

    Authors: Moing A., Allwood J. W., Aharoni A., Baker J., Beale M. H., Ben-Dor S., Biais B., Brigante F., Burger Y., Deborde C., Erban A., Faigenboim A., Gur A., Goodacre R., Hansen T. H., Jacob D., Katzir N., Kopka J., Lewinsohn E., Maucourt M., Meir S., Miller S., Mumm R., Oren E., Paris H. S., Rogachev I., Rolin D., Saar U., Schjoerring J. K., Tadmor Y., Tzuri G., de Vos R. C. H., Ward J. L., Yeselson E., Hall R. D. & Schaffer A. A. (2020), Metabolites. 10, 3, 121

  • Targeting Metabolic Plasticity and flexibility Dynamics for Cancer Therapy

    Authors: Fendt S., Frezza C. & Erez A. (2020), Cancer Discovery. 10, 12, p. 1797-1807

  • Lipidome Remodeling and Autophagic Respose in the Arachidonic-Acid-Rich Microalga Lobosphaera incisa Under Nitrogen and Phosphorous Deprivation

    Authors: Kokabi K., Gorelova O., Zorin B., Didi-Cohen S., Itkin M., Malitsky S., Solovchenko A., Boussiba S. & Khozin-Goldberg I. (2020), Frontiers in Plant Science. 11, 614846

  • Analysis of wild tomato introgression lines elucidates the genetic basis of transcriptome and metabolome variation underlying fruit traits and pathogen response

    Authors: Szymanski J., Bocobza S., Panda S., Sonawane P., Cardenas P. D., Lashbrooke J., Kamble A., Shahaf N., Meir S., Bovy A., Beekwilder J., Tikunov Y., Romero de la Fuente I., Zamir D., Rogachev I. & Aharoni A. (2020), Nature Genetics. 52, p. 1111-1121

  • Tissue-specific organic acid metabolism in reproductive and non-reproductive parts of the fig fruit is partially induced by pollination

    Authors: Lama K., Peer R., Shlizerman L., Meir S., Doron-Faigenboim A., Sadka A., Aharoni A. & Flaishman M. A. (2020), Physiologia Plantarum. 168, 1, p. 133-147

  • Crosstalk between metabolism and circadian clocks

    Authors: Reinke H. & Asher G. (2019), Nature Reviews Molecular Cell Biology. 20, 4, p. 227-241

  • Advances and future directions in betalain metabolic engineering

    Authors: Polturak G. & Aharoni A. (2019), The New Phytologist. 224, 4, p. 1472-1478

  • A Multilevel Study of Melon Fruit Reticulation Provides Insight into Skin Ligno-suberization Hallmarks

    Authors: Cohen H., Dong Y., Szymanski J., Lashbrooke J., Meir S., Almekias-Siegl E., Zeisler-Diehl V. V., Schreiber L. & Aharoni A. (2019), Plant Physiology. 179, 4, p. 1486-1501

  • Miso: An R Package for Multiple Isotope Labeling Assisted Metabolomics Data Analysis

    Authors: Dong Y., Feldberg L. & Aharoni A. (2019), Bioinformatics. 35, 18, p. 3524-3526

  • The Plant Host Induces Antibiotic Production To Select the Most-Beneficial Colonizers

    Authors: Ogran A., Yardeni E. H., Keren-Paz A., Bucher T., Jain R., Gilhar O. & Kolodkin-Gal I. (2019), Applied and Environmental Microbiology. 85, 13, UNSP e0051

  • In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids

    Authors: Schleyer G., Shahaf N., Ziv C., Dong Y., Meoded R. A., Helfrich E. J. N., Schatz D., Rosenwasser S., Rogachev I., Aharoni A., Piel J. & Vardi A. (2019), Nature Microbiology. 4, p. 527-538

  • Metabolomic foundation for differential responses of lipid metabolism to nitrogen and phosphorus deprivation in an arachidonic acid-producing green microalga

    Authors: Kokabi K., Gorelova O., Ismagulova T., Itkin M., Malitsky S., Boussiba S., Soloychenko A. & Khozin-Goldberg I. (2019), Plant Science. 283, p. 95-115

  • Transcriptome analysis and metabolic profiling reveal the key role of α-linolenic acid in dormancy regulation of European pear

    Authors: Gabay G., Faigenboim A., Dahan Y., Izhaki Y., Itkin M., Malitsky S., Elkind Y. & Flaishman M. A. (2019), Journal of Experimental Botany. 70, 3, p. 1017-1031

  • Appropriate Thiamin Pyrophosphate Levels Are Required for Acclimation to Changes in Photoperiod

    Authors: Rosado-Souza L., Proost S., Moulin M., Bergmann S., Bocobza S. E., Aharoni A., Fitzpatrick T. B., Mutwil M., Fernie A. R. & Obata T. (2019), Plant Physiology. 180, 1, p. 185-197

  • Physiological and Molecular Dissection of Daily Variance in Exercise Capacity

    Authors: Ezagouri S., Zwighaft Z., Sobel J., Baillieul S., Doutreleau S., Ladeuix B., Golik M., Verges S. & Asher G. (2019), Cell Metabolism. 30, 1, p. 78-91.e4

  • Phytobiome metabolism: Beneficial soil microbes steer crop plants' secondary metabolism

    Authors: Korenblum E. & Aharoni A. (2019), Pest Management Science. 75, 9, p. 2378-2384

  • ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus

    Authors: Lerner S., Eilam R., Kuperman Y., Tsoory M., Brandis A., Segal M., Chen A. & Erez A. (2019), Cell Reports. 29, 8, p. 2144-2153.e7

  • Tracking Root Interactions System (TRIS) Experiment and Quality Control

    Authors: Massalha H., Korenblum E., Shapiro O. H. & Aharoni A. (2019), Bio-Protocol. 9, 8, 3211

  • Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy

    Authors: Lonetto G., Koifman G., Silberman A., Attery A., Solomon H., Levin-Zaidman S., Goldfinger N., Porat Z., Erez A. & Rotter V. (2019), Cell Death and Differentiation. 26, 9, p. 1566-1581

  • Transcriptome and Metabolic Profiling Provides Insights into Betalain Biosynthesis and Evolution in Mirabilis jalapa

    Authors: Polturak G., Heinig U., Grossman N., Battat M., Leshkowitz D., Malitsky S., Rogachev I. & Aharoni A. (2018), Molecular Plant. 11, 1, p. 189-204

  • Circadian control of mitochondrial dynamics and functions

    Authors: Ezagouri S. & Asher G. (2018), Current Opinion in Physiology. 5, p. 25-29

  • Induction of Nitric-Oxide Metabolism in Enterocytes Alleviates Colitis and Inflammation-Associated Colon Cancer

    Authors: Stettner N., Rosen C., Bernshtein B., Gur-Cohen S., Frug J., Silberman A., Sarver A., Carmel-Neiderman N. N., Eilam R., Biton I., Pevsner-Fischer M., Zmora N., Brandis A., Halpern K. B., Mazkereth R., di Bernardo D., Brunetti-Pierri N., Premkumar M. H., Dank G., Nagamani S. C. S., Jung S., Harmelin A. & Erez A. (2018), Cell Reports. 23, 7, p. 1962-1976

  • Novel antibiofilm chemotherapies target nitrogen from glutamate and glutamine

    Authors: Hassanov T., Karunker I., Steinberg N., Erez A. & Kolodkin-Gal I. (2018), Scientific Reports. 8, 7097

  • Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

    Authors: Lee J. S., Adler L., Karathia H., Carmel N., Rabinovich S., Auslander N., Keshet R., Stettner N., Silberman A., Agemy L., Helbling D., Eilam R., Sun Q., Brandis A., Malitsky S., Itkin M., Weiss H., Pinto S., Kalaora S., Levy R., Barnea E., Admon A., Dimmock D., Stern-Ginossar N., Scherz A., Nagamani S. C. S., Unda M., Wilson D. M., Elhasid R., Carracedo A., Samuels Y., Hannenhalli S., Ruppin E. & Erez A. (2018), Cell. 174, 6, p. 1559-1570

  • "La Vie en Rose'': Biosynthesis, Sources, and Applications of Betalain Pigments

    Authors: Polturak G. & Aharoni A. (2018), Molecular Plant. 11, 1, p. 7-22

  • A complete pipeline for generating a high-resolution LC-MS-Based reference mass spectra library

    Authors: Shahaf N., Aharoni A. & Rogachev I. (2018), Plant Metabolomics. António C. (eds.). New York, NY: p. 193-206 (trueMethods in Molecular Biology).

  • DLEMMA-MS-Imaging for Identification of Spatially Localized Metabolites and Metabolic Network Map Reconstruction

    Authors: Feldberg L., Dong Y., Heinig U., Rogachev I. & Aharoni A. (2018), Analytical Chemistry. 90, 17, p. 10231-10238

  • Rewiring urea cycle metabolism in cancer to support anabolism

    Authors: Keshet R., Szlosarek P., Carracedo A. & Erez A. (2018), Nature Reviews Cancer. 18, 10, p. 634-645

  • Arginine and the metabolic regulation of nitric oxide synthesis in cancer

    Authors: Keshet R. & Erez A. (2018), Disease Models & Mechanisms. 11, 8, dmm033332

  • Insights into Tissue-specific Specialized Metabolism in Tieguanyin Tea Cultivar by Untargeted Metabolomics

    Authors: Chen S., Lin J., Liu H., Gong Z., Wang X., Li M., Aharoni A., Yang Z. & Yu X. (2018), Molecules. 23, 7, 1817

  • Integration of plant metabolomics data with metabolic networks: Progresses and challenges

    Authors: Töpfer N., Seaver S. M. & Aharoni A. (2018), Plant Metabolomics. António C. (eds.). p. 297-310 (trueMethods in Molecular Biology).

  • Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism

    Authors: Sonawane P. D., Pollier J., Panda S., Szymanski J., Massalha H., Yona M., Unger T., Malitsky S., Arendt P., Pauwels L., Almekias-Siegl E., Rogachev I., Meir S., Cardenas P. D., Masri A., Petrikov M., Schaller H., Schaffer A. A., Kamble A., Giri A. P., Goossens A. & Aharoni A. (2017), Nature Plants. 3, 16205

  • The polyketide synthase OsPKS2 is essential for pollen exine and Ubisch body patterning in rice

    Authors: Zhu X., Yu J., Shi J., Tohge T., Fernie A. R., Meir S., Aharoni A., Xu D., Zhang D. & Liang W. (2017), Journal of Integrative Plant Biology. 59, 9, p. 612-628

  • Metabolic Flexibility Underpins Growth Capabilities of the Fastest Growing Alga

    Authors: Treves H., Murik O., Kedem I., Eisenstadt D., Meir S., Rogachev I., Szymanski J., Keren N., Orf I., Tiburcio A. F., Alcazar R., Aharoni A., Kopka J. & Kaplan A. (2017), Current Biology. 27, 16, p. 2559-2567

  • From Prokaryotes to Cancer: Glutamine Flux in Multicellular Units

    Authors: Erez A. & Kolodkin-Gal I. (2017), Trends in Endocrinology and Metabolism. 28, 9, p. 637-644

  • Pathogen and pest responses are altered due to RNAi-mediated knockdown of GLYCOALKALOID METABOLISM 4 in solanum tuberosum

    Authors: Paudel J. R., Davidson C., Song J., Maxim I., Aharoni A. & Tai H. H. (2017), Molecular Plant-Microbe Interactions. 30, 11, p. 876-885

  • Label-free deep shotgun proteomics reveals protein dynamics during tomato fruit tissues development

    Authors: Szymanski J., Levin Y., Savidor A., Breitel D., Chappell-Maor L., Heinig U., Toepfer N. & Aharoni A. (2017), Plant Journal. 90, 2, p. 396-417

  • Repression of CYSTATHIONINE γ-SYNTHASE in seeds recruits the S-methylmethionine cycle

    Authors: Cohen H., Hacham Y., Panizel I., Rogachev I., Aharoni A. & Amir R. (2017), Plant Physiology. 174, p. 1322-1333

  • The PhytoClust tool for metabolic gene clusters discovery in plant genomes

    Authors: Topfer N., Fuchs L. & Aharoni A. (2017), Nucleic Acids Research. 45, 12, p. 7049-7063

  • Dynamic metabolic reprogramming of steroidal glycol-alkaloid and phenylpropanoid biosynthesis may impart early blight resistance in wild tomato (Solanum arcanum Peralta)

    Authors: Shinde B. A., Dholakia B. B., Hussain K., Panda S., Meir S., Rogachev I., Aharoni A., Giri A. P. & Kamble A. C. (2017), Plant Molecular Biology. 95, p. 411-423

  • Assimilation of `omics' strategies to study the cuticle layer and suberin lamellae plants

    Authors: Cohen H., Szymanski J. & Aharoni A. (2017), Journal of Experimental Botany. 68, 19, p. 5389-5400

  • The Liver in the Eyes of a Chronobiologist

    Authors: Zwighaft Z., Reinke H. & Asher G. (2016), Journal of Biological Rhythms. 31, 2, p. 115-124

  • GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway

    Authors: Cardenas P. D., Sonawane P. D., Pollier J., Vanden Bossche B. R., Dewangan V., Weithorn E., Tal L., Meir S., Rogachev I., Malitsky S., Giri A. P., Goossens A., Burdman S. & Aharoni A. (2016), Nature Communications. 7, 10654

  • A metabolic link between the urea cycle and cancer cell proliferation

    Authors: Nagamani S. C. S. & Erez A. (2016), Molecular & cellular oncology. 3, 2, 1127314

  • Persistent microbiome alterations modulate the rate of post-dieting weight regain

    Authors: Thaiss C. A., Itav S., Rothschild D., Meijer M. T., Levy M., Moresi C., Dohnalová L., Braverman S., Rozin S., Malitsky S., Dori-Bachash M., Kuperman Y., Biton I., Gertler A., Harmelin A., Shapiro H., Halpern Z., Aharoni A., Segal E. & Elinav E. (2016), Nature. 540, 7634, p. 544-551

  • A metabolic gene cluster in the wheat W1 and the barley Cer-cqu loci determines β-diketone biosynthesis and glaucousness

    Authors: Hen Avivi A. S., Savin O., Racovita R. C., Lee W., Adamski N. M., Malitsky S., Almekias-Siegl E., Levy M., Vautrin S., Berges H., Friedlander G., Kartvelishvily E., Ben-Zvi G., Alkan N., Uauy C., Kanyuka K., Jetter R., Distelfeld A. & Aharoni A. (2016), Plant Cell. 28, 6, p. 1440-1460

  • Viral infection of the marine alga Emiliania huxleyi triggers lipidome remodeling and induces the production of highly saturated triacylglycerol

    Authors: Malitsky S., Ziv C., Rosenwasser S., Zheng S., Schatz D., Porat Z., Ben-Dor S., Aharoni A. & Vardi A. (2016), New Phytologist. 210, 1, p. 88-96

  • The Circadian Nature of Mitochondrial Biology

    Authors: Manella G. & Asher G. (2016), Frontiers in Endocrinology. 7, 162

  • Characterization of a new pink-fruited tomato mutant results in the identification of a null allele of the SlMYB12 transcription factor

    Authors: Fernandez-Moreno J., Tzfadia O., Forment J., Presa S., Rogachev I., Meir S., Orzaez D., Aharoni A. & Granell A. (2016), Plant Physiology. 171, 3, p. 1821-1836

  • Circadian Clock Control of Liver Metabolic Functions

    Authors: Reinke H. & Asher G. (2016), Gastroenterology. 150, 3, p. 574-580

  • Altered metabolite accumulation in tomato fruits by coexpressing a feedback-insensitive AroG and the PhODO1 MYB-type transcription factor

    Authors: Xie Q., Liu Z., Meir S., Rogachev I., Aharoni A., Klee H. J. & Galili G. (2016), Plant Biotechnology Journal. 14, 12, p. 2300-2309

  • Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga

    Authors: Ziv C., Malitsky S., Othman A., Ben-Dor S., Wei Y., Zheng S., Aharoni A., Hornemann T. & Vardi A. (2016), Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. E1907-E1916

  • Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

    Authors: Rabinovich S., Adler L., Yizhak K., Sarver A., Silberman A., Agron S., Stettner N., Sun Q., Brandis A., Helbling D., Korman S., Itzkovitz S., Dimmock D., Ulitsky I., Nagamani S. C. S., Ruppin E. & Erez A. (2015), Nature. 527, 7578, p. 379-383

  • Altered Levels of Aroma and volatiles by Metabolic Engineering of Shikimate Pathway Genes in Tomato Fruits

    Authors: Tzin V., Rogachev I., Meir S., Ben Zvi M. M., Masci T., Vainstein A., Aharoni A. & Galili G. (2015), AIMS bioengineering. 2, 2, p. 75-92

  • The bitter side of the nightshades: Genomics drives discovery in Solanaceae steroidal alkaloid metabolism

    Authors: Cárdenas P. D., Sonawane P. D., Heinig U., Bocobza S. E., Burdman S. & Aharoni A. (2015), Phytochemistry. 113, p. 24-32

  • Metabolic dysregulation in monogenic disorders and cancer-finding method in madness

    Authors: Erez A. & DeBerardinis R. J. (2015), Nature reviews. Cancer. 15, 7, p. 440-448

  • Artificial Sweeteners Induce Glucose Intolerance by Altering the Gut Microbiota: Editorial comment

    Authors: Suez J., Korem T., Zeevi D., Zilberman-Schapira G., Thaiss C. A., Maza O., Israeli D., Zmora N., Gilad S., Weinberger A., Kuperman Y., Harmelin A., Kolodkin-Gal I., Shapiro H., Halpern Z., Segal E. & Elinav E. (2015),

  • Artificial sweeteners induce glucose intolerance by altering the gut microbiota

    Authors: Suez J., Korem T., Zeevi D., Zilberman-Schapira G., Thaiss C. A., Maza O., Israeli D., Zmora N., Gilad S., Weinberger A., Kuperman Y., Harmelin A., Kolodkin-Gal I., Shapiro H., Halpern Z., Segal E. & Elinav E. (2014), Nature. 514, 7521, p. 181-186

  • Mapping the diatom redox-sensitive proteome provides insight into response to nitrogen stress in the marine environment

    Authors: Rosenwasser S., van Creveld C. S. G., Schatz D., Malitsky S., Tzfadia O., Aharoni A., Levin Y., Gabashvili A., Feldmesser E. & Vardi A. (2014), Proceedings of the National Academy of Sciences of the United States of America. 111, 7, p. 2740-2745

  • An O-methyltransferase modifies accumulation of methylated anthocyanins in seedlings of tomato

    Authors: Roldan M. V. G., Outchkourov N., van Houwelingen H. A., Lammers M., de la Fuente l. F. I. R., Ziklo N., Aharoni A., Hall R. D. & Beekwilder J. (2014), Plant Journal. 80, 4, p. 695-708

  • SEEDSTICK is a Master Regulator of Development and Metabolism in the Arabidopsis Seed Coat

    Authors: Mizzotti C., Ezquer I., Paolo D., Rueda-Romero P., Guerra R. F., Battaglia R., Rogachev I., Aharoni A., Kater M. M., Caporali E. & Colombo L. (2014), PLoS Genetics. 10, 12

  • Small molecules that interact with RNA: riboswitch-based gene control and its involvement in metabolic regulation in plants and algae

    Authors: Bocobza S. E. & Aharoni A. (2014), Plant Journal. 79, 4, p. 693-703

  • Rewiring host lipid metabolism by large viruses determines the fate of Emiliania huxleyi, a bloom-forming alga in the ocean

    Authors: Rosenwasser S., Mausz M. A., Schatz D., Sheyn U., Malitsky S., Aharoni A., Weinstock E., Tzfadia O., Ben-Dor S., Feldmesser E., Pohnert G. & Vardi A. (2014), Plant Cell. 26, 6, p. 2689-2707

  • Argininosuccinic aciduria: From a monogenic to a complex disorder

    Authors: Erez A. (2013), Genetics in Medicine. 15, 4, p. 251-257

  • The challenges of cellular compartmentalization in plant metabolic engineering

    Authors: Heinig U., Gutensohn M., Dudareva N. & Aharoni A. (2013), Current Opinion in Biotechnology. 24, 2, p. 239-246

  • High-resolution metabolic mapping of cell types in plant roots

    Authors: Moussaieff A., Rogachev I., Brodsky L., Malitsky S., Toal T. W., Belcher H., Yativ M., Brady S. M., Benfey P. N. & Aharoni A. (2013), Proceedings of the National Academy of Sciences of the United States of America. 110, 13, p. E1232-E1241

  • Overexpression of AtSHN1/WIN1 Provokes Unique Defense Responses

    Authors: Sela D., Buxdorf K., Shi J., Feldmesser E., Schreiber L., Aharoni A. & Levy M. (2013), PLoS ONE. 8, 7, e70146

  • Orchestration of thiamin biosynthesis and central metabolism by combined action of the thiamin pyrophosphate riboswitch and the circadian clock in Arabidopsis

    Authors: Bocobza S. E., Malitsky S., Araujo W. L., Nunes-Nesi A., Meir S., Shapira M., Fernie A. R. & Aharoni A. (2013), Plant Cell. 25, 1, p. 288-307

  • In vitro microbiotic fermentation causes an extensive metabolite turnover of rye bran phytochemicals

    Authors: Hanhineva K., Aura A. M., Rogachev I., Matero S., Skov T., Aharoni A., Poutanen K. & Mykkänen H. (2012), PLoS ONE. 7, 6, e39322

  • Discovery of new modules in metabolic biology using chemometabolomics

    Authors: Bocobza S., Willmitzer L., Raikhel N. V. & Aharoni A. (2012),

  • UPLC-MS-based metabolite analysis in tomato

    Authors: Rogachev I. & Aharoni A. (2012), Plant Metabolomics. Hardy N. & Hall R. (eds.). p. 129-144 (trueMethods in Molecular Biology).

  • Identification of novel lignans in the whole grain rye bran by non-targeted LC-MS metabolite profiling

    Authors: Hanhineva K., Rogachev I., Aura A. M., Aharoni A., Poutanen K. & Mykkänen H. (2012), Metabolomics. 8, 3, p. 399-409

  • Co-mapping studies of QTLs for fruit acidity and candidate genes of organic acid metabolism and proton transport in sweet melon (Cucumis melo L.)

    Authors: Cohen S., Tzuri G., Harel-Beja R., Itkin M., Portnoy V., Sa'ar U., Lev S., Yeselson L., Petrikov M., Rogachev I., Aharoni A., Ophir R., Tadmor Y., Lewinsohn E., Burger Y., Katzir N. & Schaffer A. A. (2012), Theoretical And Applied Genetics. 125, 2, p. 343-353

  • Reconstruction of Arabidopsis metabolic network models accounting for subcellular compartmentalization and tissue-specificity

    Authors: Mintz-Oron S., Meir S., Malitsky S., Ruppin E., Aharoni A. & Shlomi T. (2012), Proceedings of the National Academy of Sciences of the United States of America. 109, 1, p. 339-344

  • Argininosuccinate lyase deficiency

    Authors: Nagamani S. C., Erez A. & Lee B. (2012), Genetics in Medicine. 14, 5, p. 501-507

  • Cell type-specific transcriptional profiling: implications for metabolite profiling

    Authors: Rogers E. D., Jackson T., Moussaieff A., Aharoni A. & Benfey P. N. (2012), Plant Journal. 70, 1, p. 5-17

  • Expression of a bacterial feedback-insensitive 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway in Arabidopsis elucidates potential metabolic bottlenecks between primary and secondary metabolism

    Authors: Tzin V., Malitsky S., Ben Zvi Z. M. M., Bedair M., Sumner L., Aharoni A. & Galili G. (2012), NEW PHYTOLOGIST. 194, 2, p. 430-439

  • Sortin1-hypersensitive mutants link vacuolar-trafficking defects and flavonoid metabolism in Arabidopsis vegetative tissues

    Authors: Rosado A., Hicks G. R., Norambuena L., Rogachev I., Meir S., Pourcel L., Zouhar J., Brown M. Q., Boirsdore M. P., Puckrin R. S., Cutler S. R., Rojo E., Aharoni A. & Raikhel N. V. (2011), Chemistry and Biology. 18, 2, p. 187-197

  • Insights into the pathogenesis and treatment of cancer from inborn errors of metabolism

    Authors: Erez A., Shchelochkov O. A., Plon S. E., Scaglia F. & Lee B. (2011), American Journal of Human Genetics. 88, 4, p. 402-421

  • KaPPA-View4: A metabolic pathway database for representation and analysis of correlation networks of gene co-expression and metabolite co-accumulation and omics data

    Authors: Sakurai N., Ara T., Ogata Y., Sano R., Ohno T., Sugiyama K., Hiruta A., Yamazaki K., Yano K., Aoki K., Aharoni A., Hamada K., Yokoyama K., Kawamura S., Otsuka H., Tokimatsu T., Kanehisa M., Suzuki H., Saito K. & Shibata D. (2011), Nucleic Acids Research. 39, SUPPL. 1, p. D677-D684

  • JA-Ile signalling in Solanum nigrum is not required for defence responses in nature

    Authors: Vandoorn A., Bonaventure G., Rogachev I., Aharoni A. & Baldwin I. T. (2011), Plant Cell And Environment. 34, 12, p. 2159-2171

  • SHINE transcription factors act redundantly to pattern the archetypal surface of arabidopsis flower organs

    Authors: Shi J., Malitsky S., De Oliveira O. S., Branigan C., Franke R. B., Schreiber L. & Aharoni A. (2011), PLoS Genetics. 7, 5, e1001388

  • Extensive metabolic cross-talk in melon fruit revealed by spatial and developmental combinatorial metabolomics

    Authors: Moing A., Aharoni A., Biais B., Rogachev I., Meir S., Brodsky L., Allwood J. W., Erban A., Dunn W. B., Kay L., de Koning K. S., de Vos V. R. C. H., Jonker H., Mumm R., Deborde C., Maucourt M., Bernillon S., Gibon Y. & Hansen T. H. (2011), NEW PHYTOLOGIST. 190, 3, p. 683-696

  • Metabolic engineering of the plant primary-secondary metabolism interface

    Authors: Aharoni A. & Galili G. (2011), Current Opinion in Biotechnology. 22, 2, p. 239-244

  • Tissue- and cell-type specific transcriptome profiling of expanding tomato fruit provides insights into metabolic and regulatory specialization and cuticle formation

    Authors: Matas A. J., Yeats T. H., Buda G. J., Zheng Y., Chatterjee S., Tohge T., Ponnala L., Adato A., Aharoni A., Stark R., Fernie A. R., Fei Z., Giovannoni J. J. & Rose J. K. C. (2011), Plant Cell. 23, 11, p. 3893-3910

  • Evaluation of peak picking quality in LC-MS metabolomics data

    Authors: Brodsky L., Moussaieff A., Shahaf N., Aharoni A. & Rogachev I. (2010), Analytical Chemistry. 82, 22, p. 9177-9187

  • Metabolic networking in Brunfelsia calycina petals after flower opening

    Authors: Bar-Akiva A., Ovadia R., Rogachev I., Bar-Or C., Bar E., Freiman Z., Nissim-Levi A., Gollop N., Lewinsohn E., Aharoni A., Weiss D., Koltai H. & Oren-Shamir M. (2010), Journal of Experimental Botany. 61, 5, p. 1393-1403

  • An orange ripening mutant links plastid NAD(P)H dehydrogenase complex activity to central and specialized metabolism during tomato fruit maturation

    Authors: Nashilevitz S., Melamed-Bessudo C., Izkovich Y., Rogachev I., Osorio S., Itkin M., Adato A., Pankratov I., Hirschberg J., Fernie A. R., Wolf S., Usadel B., Levy A., Rumeau D. & Aharoni A. (2010), Plant Cell. 22, 6, p. 1977-1997