"Though the city used to be called Luz" –SIRT6, aging and beyond.
Date:
Lecture / Seminar
Time: 11:00-12:00
Title: The mammalian longevity associated acetylome
Location: Arthur and Rochelle Belfer Building for Biomedical Research
Lecturer: Dr. Haim Cohen
Organizer: Sagol Institute for Longevity Research
Abstract: Despite extensive studies at the genomic, transcriptomic, and metabolomic levels ... Read more Despite extensive studies at the genomic, transcriptomic, and metabolomic levels, the underlying mechanisms regulating longevity remain incompletely understood. Post-translational protein acetylation has been suggested to regulate aspects of longevity. To further explore the role of acetylation, we developed the PHARAOH computational tool, based on the 100-fold differences in longevity within the mammalian class. Analyzing acetylome and proteome data across 107 mammalian species identified multiple significant longevity-associated acetylated lysine residues in mice and humans, controlling many longevity-related pathways. Specifically, we found that longevity-associated acetylation sites help resolve the Peto Paradox: the enigma of why animals with increased body size live longer yet do not exhibit much higher cancer incidence. Our findings show a significant positive correlation between these new acetylation sites and protection against multiple types of cancer in humans. Moreover, mutating these sites reduced the anti-neoplastic functions of the acetylated proteins. These findings provide new insights into the pivotal role of protein acetylation in mammalian longevity, suggesting potential interventions to extend human healthspan.Close abstract
