• Survivorship Data in Prostate Cancer: Where Are We and Where Do We Need To Be?

    Authors: Russell B., Beyer K., Lawlor A., Roobol M. J., Venderbos L. D., Remmers S., Briers E., MacLennan S. J., MacLennan S., Omar M. I., Van Hemelrijck M., Smith E., N'Dow J., Plass K., Ribal M., Mottet N., Shepherd R., Abbott T., Mastris K. & Lancet D. (2024),
  • Real-Time Model-Based Quantitative Ultrasound and Radar

    Authors: Sharon T. & Eldar Y. C. (2024), IEEE Transactions on Computational Imaging. 10, p. 1175-1190
  • Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma

    Authors: Kirschenbaum D., Xie K., Ingelfinger F., Katzenelenbogen Y., Abadie K., Look T., Sheban F., Phan T. S., Li B., Zwicky P., Yofe I., David E., Mazuz K., Hou J., Chen Y., Shaim H., Shanley M., Becker S., Qian J., Colonna M., Ginhoux F., Rezvani K., Theis F. J., Yosef N., Weiss T., Weiner A. & Amit I. (2024), Cell. 187, 1, p. 149-165.e23
  • Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors

    Authors: Tirosh I. & Suva M. L. (2024), Cancer Cell. 42, 9, p. 1497-1506
  • Potent antitumor activity of anti-HER2 antibody-topoisomerase I inhibitor conjugate based on self-immolative dendritic dimeric-linker

    Authors: Liubomirski Y., Tiram G., Scomparin A., Gnaim S., Das S., Gholap S., Ge L., Yeini E., Shelef O., Zauberman A., Berger N., Kalimi D., Toister-Achituv M., Schröter C., Dickgiesser S., Tonillo J., Shan M., Deutsch C., Sweeney-Lasch S., Shabat D. & Satchi-Fainaro R. (2024), Journal of Controlled Release. 367, p. 148-157
  • Recycled melanoma-secreted melanosomes regulate tumor-associated macrophage diversification

    Authors: Parikh R., Parikh S., Berzin D., Vaknine H., Ovadia S., Likonen D., Greenberger S., Scope A., Elgavish S., Nevo Y., Plaschkes I., Nizri E., Kobiler O., Maliah A., Zaremba L., Mohan V., Sagi I., Ashery-Padan R., Carmi Y., Luxenburg C., Hoheisel J. D., Khaled M., Levesque M. P. & Levy C. (2024), EMBO Journal. 43, 17, p. 3553-3586
  • IL-23 stabilizes an effector Treg cell program in the tumor microenvironment

    Authors: Wertheimer T., Zwicky P., Rindlisbacher L., Sparano C., Vermeer M., de Melo B. M. S., Haftmann C., Rückert T., Sethi A., Schärli S., Huber A., Ingelfinger F., Xu C., Kim D., Häne P., Fonseca da Silva A., Muschaweckh A., Nunez N., Krishnarajah S., Köhler N., Zeiser R., Oukka M., Korn T., Tugues S. & Becher B. (2024), Nature Immunology. 25, 3, p. 512-524
  • Longitudinal single-cell data informs deterministic modelling of inflammatory bowel disease

    Authors: Kilian C., Ulrich H., Zouboulis V. A., Sprezyna P., Schreiber J., Landsberger T., Büttner M., Biton M., Villablanca E. J., Huber S. & Adlung L. (2024), npj Systems Biology and Applications. 10, 69
  • Unlocking the Role of Age-Related Changes to Fibroblasts in Pancreatic Cancer

    Authors: Isaacson A., Barki D. & Scherz-Shouval R. (2024),
  • ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response

    Authors: Lim L. Q. J., Adler L., Hajaj E., Soria L. R., Perry R. B. T., Darzi N., Brody R., Furth N., Lichtenstein M., Bab-Dinitz E., Porat Z., Melman T., Brandis A., Aylon Y., Ben-Dor S., Orr I., Pri-Or A., Seger R., Shaul Y., Ruppin E., Oren M., Perez M., Meier J., Brunetti-Pierri N., Shema E., Ulitsky I., Erez A., Malitsky S. & Itkin M. (2024), Nature metabolism. 6, 7, p. 1294-1309
  • CAF-induced physical constraints controlling T cell state and localization in solid tumours

    Authors: Arpinati L., Carradori G. & Scherz-Shouval R. (2024), Nature Reviews Cancer. 24, 10, p. 676-693
  • Dual targeting of histone deacetylases and myc as potential treatment strategy for h3- k27m pediatric gliomas

    Authors: Algranati D., Oren R., Dassa B., Fellus-Alyagor L., Plotnikov A., Barr H., Harmelin A., London N., Ron G., Furth N. & Shema E. (2024), eLife. 13, RP96257
  • HSF1 renders NK cells too stressed to respond

    Authors: Gruper Y., Ben-Shmuel A. & Scherz-Shouval R. (2024),
  • Meet the authors: Guy Zoltsman and Rina Rosenzweig

    Authors: Zoltsman G. & Rosenzweig R. (2024), Molecular Cell. 84, 8, p. 1396-1397
  • Exploiting Urea-Carboxylate Synthon for Designing Supramolecular Topical Hydrogel via Simple Organic Salt Formation: Synthesis, Crystal Structures, and Anticancer Behavior against Melanoma B16-F10 Cells

    Authors: Chakraborty P., Roy N., Biswas P., Biswas D. S., Datta H. K., Dutta A. & Dastidar P. (2024), Chemistry of Materials. 36, 15, p. 7317-7331
  • Measuring and modeling the dynamics of mitotic error correction

    Authors: Ha G., Dieterle P., Shen H., Amir A. & Needleman D. J. (2024), Proceedings of the National Academy of Sciences. 121, 25, e232300912
  • Embracing cancer complexity: Hallmarks of systemic disease

    Authors: Swanton C., Bernard E., Abbosh C., André F., Auwerx J., Balmain A., Bar-Sagi D., Bernards R., Bullman S., DeGregori J., Elliott C., Erez A., Evan G., Febbraio M. A., Hidalgo A., Jamal-Hanjani M., Joyce J. A., Kaiser M., Lamia K., Locasale J. W., Loi S., Malanchi I., Merad M., Musgrave K., Patel K. J., Quezada S., Wargo J. A., Weeraratna A., White E., Winkler F., Wood J. N., Vousden K. H. & Hanahan D. (2024), Cell. 187, 7, p. 1589-1616
  • Human MAIT cells inhibit alloreactive T cell responses and protect against acute graft-versus-host disease

    Authors: Talvard-Balland N., Lambert M., Chevalier M. F., Minet N., Salou M., Tourret M., Bohineust A., Milo I., Parietti V., Yvorra T., Socié G., Lantz O. & Caillat-Zucman S. (2024), JCI Insight. 9, 5, e166310
  • Improving Microstructural Estimation in Time-Dependent Diffusion MRI With a Bayesian Method

    Authors: Liu K., Lin Z., Zheng T., Ba R., Zhang Z., Li H., Zhang H., Tal A. & Wu D. (2024), Journal of Magnetic Resonance Imaging.
  • The tumor-driven antibody-mediated immune response in cancer

    Authors: Paparoditis P. & Shulman Z. (2024), Current Opinion in Immunology. 88, 102431
  • Microbiome modulation of antigen presentation in tolerance and inflammation

    Authors: He Y., Mohapatra G., Asokan S., Nobs S. P. & Elinav E. (2024), Current Opinion in Immunology. 91, 102471
  • Cell-penetrating peptide and cationic liposomes mediated siRNA delivery to arrest growth of chronic myeloid leukemia cells in vitro

    Authors: Vysochinskaya V., Zabrodskaya Y., Dovbysh O., Emelyanov A., Klimenko V., Knyazev N., Terterov I., Egorova M., Bogdanov A., Maslov M., Vasin A. & Dubina M. (2024), Biochimie. 221, p. 1-12
  • Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor

    Authors: Meril S., Bahlsen M., Eisenstein M., Savidor A., Levin Y., Bialik S., Pietrokovski S. & Kimchi A. (2024), Life Science Alliance. 7, 3, e202302338
  • Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma

    Authors: Spitzer A., Gritsch S., Nomura M., Jucht A., Fortin J., Raviram R., Weisman H. R., Gonzalez Castro L. N., Druck N., Chanoch-Myers R., Lee J. J., Mylvaganam R., Lee Servis R., Fung J. M., Lee C. K., Nagashima H., Miller J. J., Arrillaga-Romany I., Louis D. N., Wakimoto H., Pisano W., Wen P. Y., Mak T. W., Sanson M., Touat M., Landau D. A., Ligon K. L., Cahill D. P., Suvà M. L. & Tirosh I. (2024), Cancer Cell. 42, 5, p. 904-914.e9
  • ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP

    Authors: Abbas R., Hartmann O., Asiss D. T., Abbas R., Kagan J., Kim H. T., Oren M., Diefenbacher M., Orian A. & Larisch S. (2024), Apoptosis. 29, 7-8, p. 1145-1160
  • Emergent seesaw oscillations during cellular directional decision-making

    Authors: Ron J. E., Crestani M., Kux J. M., Liu J., Al-Dam N., Monzo P., Gauthier N. C., Sáez P. J. & Gov N. S. (2024), Nature Physics. 20, 3, p. 501-511
  • Elemental Characterization of Ambient Particulate Matter for a Globally Distributed Monitoring Network: Methodology and Implications

    Authors: Liu X., Turner J. R., Oxford C. R., McNeill J., Walsh B., Le Roy E., Weagle C. L., Stone E., Zhu H., Liu W., Wei Z., Hyslop N. P., Giacomo J., Dillner A. M., Salam A., Hossen A., Islam Z., Abboud I., Akoshile C., Amador-Muñoz O., Anh N. X., Asfaw A., Balasubramanian R., Chang R. Y., Coburn C., Dey S., Diner D. J., Dong J., Farrah T., Gahungu P., Garland R. M., Grutter de la Mora M., Hasheminassab S., John J., Kim J., Kim J. S., Langerman K., Lee P., Lestari P., Liu Y., Mamo T., Martins M., Mayol-Bracero O. L., Naidoo M., Park S. S., Schechner Y., Schofield R., Tripathi S. N., Windwer E., Wu M., Zhang Q., Brauer M., Rudich Y. & Martin R. V. (2024), ACS EST Air. 1, 4, p. 283-293
  • Acute Toxicity and Early Prostate Specific Antigen Response After Two-Fraction Stereotactic Radiation Therapy for Localized Prostate Cancer Using Peri-Rectal Spacing Initial Report of the SABR-Dual Trial

    Authors: Fredman E., Moore A., Icht O., Tschernichovsky R., Shemesh D., Bragilovski D., Kindler J., Golan S., Shochet T. & Limon D. (2024), International Journal of Radiation Oncology Biology Physics.
  • Cancer Hallmarks: Piecing the Puzzle Together

    Authors: Alcolea M. P., Alonso-Curbelo D., Ambrogio C., Bullman S., Correia A. L., Ernst A., Halbrook C. J., Kelly G. L., Lund A. W., Quail D. F., Ruscetti M., Shema E., Stromnes I. M. & Tam W. L. (2024), Cancer Discovery. 14, 4, p. 674-682
  • Health impacts of biomass burning aerosols: Relation to oxidative stress and inflammation

    Authors: Pardo M., Li C., Zimmermann R. & Rudich Y. (2024), Aerosol Science and Technology.
  • Single-cell atlas of the human brain vasculature across development, adulthood and disease

    Authors: Wälchli T., Ghobrial M., Schwab M., Takada S., Zhong H., Suntharalingham S., Vetiska S., Gonzalez D. R., Wu R., Rehrauer H., Dinesh A., Yu K., Chen E. L., Bisschop J., Farnhammer F., Mansur A., Kalucka J., Tirosh I., Regli L., Schaller K., Frei K., Ketela T., Bernstein M., Kongkham P., Carmeliet P., Valiante T., Dirks P. B., Suva M. L., Zadeh G., Tabar V., Schlapbach R., Jackson H. W., De Bock K., Fish J. E., Monnier P. P., Bader G. D. & Radovanovic I. (2024), Nature. 632, 8025, p. 603-613
  • Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy

    Authors: Maliah A., Santana-Magal N., Parikh S., Gordon S., Reshef K., Sade Y., Khateeb A., Richter A., Gutwillig A., Parikh R., Golan T., Krissi M., Na M., Binshtok G., Manich P., Elkoshi N., Grisaru-Tal S., Zemser-Werner V., Brenner R., Vaknine H., Nizri E., Moyal L., Amitay-Laish I., Rosemberg L., Munitz A., Kronfeld-Schor N., Shifrut E., Kobiler O., Madi A., Geiger T., Carmi Y. & Levy C. (2024), Nature Communications. 15, 8354
  • A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53

    Authors: Zoltsman G., Dang T. L., Kuchersky M., Faust O., Silva M. S., Ilani T., Wentink A. S., Bukau B. & Rosenzweig R. (2024), Molecular Cell. 84, 8, p. 1512-1526.e9
  • FcγRIIB is an immune checkpoint limiting the activity of Treg-targeting antibodies in the tumor microenvironment

    Authors: Knorr D. A., Blanchard L., Leidner R. S., Jensen S. M., Meng R., Jones A., Ballesteros-Merino C., Bell R. B., Baez M., Marino A., Sprott D., Bifulco C. B., Piening B., Dahan R., Osorio J. C., Fox B. A. & Ravetch J. V. (2024), Cancer Immunology Research. 12, 3, p. 322-333
  • Targeting of mutant-p53 and MYC as a novel strategy to inhibit oncogenic SPAG5 activity in triple negative breast cancer

    Authors: Canu V., Vaccarella S., Sacconi A., Pulito C., Goeman F., Pallocca M., Rutigliano D., Lev S., Strano S. & Blandino G. (2024), Cell Death and Disease. 15, 603
  • Identification of gene fusions associated with amyotrophic lateral sclerosis

    Authors: Raghav Y., Dilliott A. A., Petrozziello T., Kim S. E., Berry J. D., Cudkowicz M. E., Vakili K., Phatnani H., Kwan J., Sareen D., Broach J. R., Simmons Z., Arcila-Londono X., Lee E. B., Van Deerlin V. M., Shneider N. A., Fraenkel E., Ostrow L. W., Baas F. & Hornstein E. (2024), Muscle and Nerve.
  • Genomic linkages dictate cancer evolution

    Authors: Snarski Y. B. O. & Shoshani O. (2024),
  • Comparative study of immune response to local tumor destruction modalities in a murine breast cancer model

    Authors: Budhu S., Kim K., Yip W., La Rosa S., Jebiwott S., Cai L., Holland A., Thomas J., Preise D., Somma A., Gordon B., Scherz A., Wolchok J. D., Erinjeri J., Merghoub T. & Coleman J. A. (2024), Frontiers in Oncology. 14, 1405486
  • From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments

    Authors: Hajaj E., Pozzi S. & Erez A. (2024), Cold Spring Harbor perspectives in medicine. 14, 4, a041538
  • Targeting Tumor-Associated Sialic Acids Using Chimeric Switch Receptors Based on Siglec-9 Enhances the Antitumor Efficacy of Engineered T Cells

    Authors: Eisenberg V., Hoogi S., Katzman E., Ben Haim N., Zur-Toledano R., Radman M., Reboh Y., Zadok O., Kamer I., Bar J., Sagi I., Hendel A. & Cohen C. J. (2024), Cancer Immunology Research. 12, 10, p. 1380-1391
  • Molecular mechanisms underlying the modulation of T-cell proliferation and cytotoxicity by immobilized CCL21 and ICAM1

    Authors: Yado S., Dassa B., Zoabi R., Reich-Zeliger S., Friedman N. & Geiger B. (2024), Journal for ImmunoTherapy of Cancer. 12, 6, e009011
  • Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity

    Authors: Farhat-Younis L., Na M., Zarfin A., Khateeb A., Santana-Magal N., Richter A., Gutwillig A., Rasoulouniriana D., Gleiberman A., Beck L., Giger T., Ashkenazi A., Barzel A., Rider P. & Carmi Y. (2024), eLife. 12, RP91999
  • Medical Image Segmentation Using Directional Window Attention

    Authors: Kareem D. N. A., Fiaz M., Novershtern N. & Cholakkal H. (2024), IEEE International Symposium on Biomedical Imaging, ISBI 2024 - Conference Proceedings.
  • Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

    Authors: Lü Y. Q., Cho T., Mukherjee S., Suarez C. F., Gonzalez-Foutel N. S., Malik A., Martinez S., Dervovic D., Oh R. H., Langille E., Al-Zahrani K. N., Hoeg L., Lin Z. Y., Tsai R., Mbamalu G., Rotter V., Ashton-Prolla P., Moffat J., Chemes L. B., Gingras A. C., Oren M., Durocher D. & Schramek D. (2024), Molecular Systems Biology. 20, 6, p. 719-740
  • Update on current and new potential immunotherapies in breast cancer, from bench to bedside

    Authors: Alaluf E., Shalamov M. M. & Sonnenblick A. (2024), Frontiers in Immunology. 15, 1287824
  • The role of CCL2/CCR2 axis in cancer and inflammation: The next frontier in nanomedicine

    Authors: Pozzi S. & Satchi-Fainaro R. (2024), Advanced Drug Delivery Reviews. 209, 115318
  • PIONEER big data platform for prostate cancer: lessons for advancing future real-world evidence research

    Authors: Lawlor A., Beyer K., Russell B., Steinbeisser C., Bjartell A., De Meulder B., Omar M. I., Hulsen T., Butler J., NDow J., Rivas J. G., Gandaglia G., Nicoletti R., Sakalis V., Smith E. J., Maass M., Zong J., Fullwood L., Abbott T. & Lancet D. (2024), Nature Reviews Urology.
  • Molecular imaging of tumor metabolism: Insight from pyruvate- and glucose-based deuterium MRI studies

    Authors: Montrazi E. T., Sasson K., Agemy L., Scherz A. & Frydman L. (2024), Science advances. 10, 11, eadm8600
  • Converging survival trends in non-small cell lung cancer patients with and without brain metastasis receiving state-of-the-art treatment

    Authors: Averbuch I., Tschernichovsky R., Yust-Katz S., Rotem O., Limon D., Kurman N., Icht O., Reinhorn D., Moskovitz M., Hanovich E., Benouaich-Amiel A., Siegal T., Zer A. & Gal O. (2024), Journal of Neuro-Oncology. 166, p. 461-469
  • A hybrid epithelial/mesenchymal state in head and neck cancer: A biomarker for survival with differential prognosis by self-reported race

    Authors: Mazul A. L., Barrett T. F., Colditz G., Parikh A. S., Ramadan S., Zevallos J. P., Rich J. T., Harbison R. A., Jackson R. S., Pipkorn P., Zolkind P., Tirosh I. & Puram S. V. (2024), Med. 5, 7, p. 826-831.e3
  • The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects

    Authors: Van Der Byl W., Nüssing S., Peters T. J., Ahn A., Li H., Ledergor G., David E., Koh A. S., Wagle M. V., Deguit C. D. T., de Menezes M. N., Travers A., Sampurno S., Ramsbottom K. M., Li R., Kallies A., Beavis P. A., Jungmann R., Bastings M. M., Belz G. T., Goel S., Trapani J. A., Crabtree G. R., Chang H. Y., Amit I., Goodnow C. C., Luciani F. & Parish I. A. (2024), Immunity. 57, 6, p. 1324-1344.e8
  • Mapping the tumor stress network reveals dynamic shifts in the stromal oxidative stress response

    Authors: Lior C., Barki D., Halperin C., Iacobuzio-Donahue C. A., Kelsen D. & Shouval R. S. (2024), Cell Reports. 43, 5, 114236
  • Site-specific serology unveils cross-reactive monoclonal antibodies targeting influenza A hemagglutinin epitopes

    Authors: Paparoditis P. C., Fruehwirth A., Bevc K., Low J. S., Jerak J., Terzaghi L., Foglierini M., Fernandez B., Jarrossay D., Corti D., Sallusto F., Lanzavecchia A. & Cassotta A. (2024), European Journal of Immunology. 54, 10, 2451045
  • Generation of Non-Alloreactive Antiviral Central Memory CD8 Human Veto T Cells for Cell Therapy

    Authors: Bachar-Lustig E., Lask A., Eidelstein Y., Or-Geva N., Gidron-Budovsky R., Nathansohn-Levy B., Eyrich M., Liu W. H., Dang G., Miranda K. C., Ramirez A., Kaur I., Rezvani K., Shpall E., Champlin R. E., Nagler A., Shimoni A., Barnees-Kagan S. & Reisner Y. (2024), Transplantation and Cellular Therapy. 30, 1, p. 71.e1-71.e13
  • Motility driven glassy dynamics in confluent epithelial monolayers

    Authors: Sadhukhan S., Nandi M. K., Pandey S., Paoluzzi M., Dasgupta C., Gov N. S. & Nandi S. K. (2024), Soft Matter. 20, 31, p. 6160-6175
  • A snapshot into the transcriptomic landscape of apoptosis and ferroptosis in cancer

    Authors: Vinik Y. & Lev S. (2024),
  • Detecting bone lesions in X-ray under diverse acquisition conditions

    Authors: Zimbalist T., Rosen R., Peri-Hanania K., Caspi Y., Rinott B., Zeltser-Dekel C., Bercovich E., Eldar Y. C. & Bagon S. (2024), Journal of Medical Imaging. 11, 2, 024502
  • A microbial iron fist to fight tumors

    Authors: Nobs S. P. & Elinav E. (2024),
  • Exploring the role of artificial intelligence, large language models: Comparing patient-focused information and clinical decision support capabilities to the gynecologic oncology guidelines: Comparing patient-focused information and clinical decision support capabilities to the gynecologic oncology guidelines

    Authors: Reicher L., Lutsker G., Michaan N., Grisaru D. & Laskov I. (2024), International Journal of Gynecology and Obstetrics.
  • Bispecific dendritic-T cell engager potentiates anti-tumor immunity

    Authors: Shapir Itai Y., Barboy O., Salomon R., Bercovich A., Xie K., Winter E., Shami T., Porat Z., Erez N., Tanay A., Amit I. & Dahan R. (2024), Cell. 187, 2, p. 375-389.e18
  • Guidelines for minimal information on cellular senescence experimentation in vivo

    Authors: Ogrodnik M., Carlos Acosta J., Adams P. D., d'Adda di Fagagna F., Baker D. J., Bishop C. L., Chandra T., Collado M., Gil J., Gorgoulis V., Gruber F., Hara E., Jansen-Dürr P., Jurk D., Khosla S., Kirkland J. L., Krizhanovsky V., Minamino T., Niedernhofer L. J., Passos J. F., Ring N. A., Redl H., Robbins P. D., Rodier F., Scharffetter-Kochanek K., Sedivy J. M., Sikora E., Witwer K., von Zglinicki T., Yun M. H., Grillari J. & Demaria M. (2024), Cell. 187, 16, p. 4150-4175
  • Sonodynamic Therapy for HER2+ Breast Cancer with Iodinated Heptamethine CyanineTrastuzumab Conjugate

    Authors: Kobzev D., Semenova O., Aviel-Ronen S., Kulyk O., Carmieli R., Mirzabekov T., Gellerman G. & Patsenker L. (2024), International Journal of Molecular Sciences. 25, 18, 10137
  • Structureactivity relationship study of small-molecule inhibitor of Atg12-Atg3 proteinprotein interaction

    Authors: Skach K., Boserle J., Břehová P., Chaloupecká E., Nencka R., Skach K., Nuta G. C., Bialik S., Kimchi A., Carvalho S., Kozer N. & Barr H. (2024), Bioorganic and Medicinal Chemistry Letters. 112, 129939
  • Programming a Ferroptosis-to-Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy

    Authors: Vinik Y., Maimon A., Dubey V., Raj H., Abramovitch I., Malitsky S., Itkin M., Ma'ayan A., Westermann F., Gottlieb E., Ruppin E. & Lev S. (2024), Advanced Science. 11, 17, 2307263
  • Fast T1 mapping MRI in preclinical and clinical settings using subspace-constrained joint-domain reconstructions

    Authors: Ma L., Bao Q., Martinho R. P., Chen Z. & Frydman L. (2024), Magnetic Resonance Letters. 200134
  • p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells

    Authors: Majewska J., Agrawal A., Mayo A., Roitman L., Chatterjee R., Sekeresova Kralova J., Landsberger T., Katzenelenbogen Y., Meir-Salame T., Hagai E., Sopher I., Perez-Correa J. F., Wagner W., Maimon A., Amit I., Alon U. & Krizhanovsky V. (2024), Nature Cell Biology. 26, 8, p. 1336-1345
  • Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment

    Authors: Schmidt D., Endres C., Hoefflin R., Andrieux G., Zwick M., Karantzelis N., Staehle H. F., Vinnakota J. M., Duquesne S., Mozaffari Jovein M., Pfeifer D., Becker H., Blazar B. R., Zähringer A., Duyster J., Brummer T., Boerries M., Baumeister J., Shoumariyeh K., Li J., Green A. R., Heidel F. H., Tirosh I., Pahl H. L., Leimkühler N., Köhler N., de Toledo M. A., Koschmieder S. & Zeiser R. (2024), Cancer Research. 84, 18, p. 2985-3003
  • Defining myeloid-derived suppressor cells

    Authors: Akkari L., Amit I., Bronte V., Fridlender Z. G., Gabrilovich D. I., Ginhoux F., Hedrick C. C. & Ostrand-Rosenberg S. (2024), Nature Reviews Immunology.
  • Aberrant nuclei with amplified DNA in cancer

    Authors: Kadali V. N. & Shoshani O. (2024),
  • Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer

    Authors: Bojmar L., Zambirinis C. P., Hernandez J. M., Chakraborty J., Shaashua L., Kim J., Johnson K. E., Hanna S., Askan G., Burman J., Ravichandran H., Zheng J., Jolissaint J. S., Srouji R., Song Y., Choubey A., Kim H. S., Cioffi M., van Beek E., Sigel C., Jessurun J., Velasco Riestra P., Blomstrand H., Jönsson C., Jönsson A., Lauritzen P., Buehring W., Ararso Y., Hernandez D., Vinagolu-Baur J. P., Friedman M., Glidden C., Firmenich L., Lieberman G., Mejia D. L., Nasar N., Mutvei A. P., Paul D. M., Bram Y., Costa-Silva B., Basturk O., Boudreau N., Zhang H., Matei I. R., Hoshino A., Kelsen D., Sagi I., Scherz A., Scherz-Shouval R., Yarden Y., Oren M., Egeblad M., Lewis J. S., Keshari K., Grandgenett P. M., Hollingsworth M. A., Rajasekhar V. K., Healey J. H., Björnsson B., Simeone D. M., Tuveson D. A., Iacobuzio-Donahue C. A., Bromberg J., Vincent C. T., OReilly E. M., DeMatteo R. P., Balachandran V. P., DAngelica M. I., Kingham T. P., Allen P. J., Simpson A. L., Elemento O., Sandström P., Schwartz R. E., Jarnagin W. R. & Lyden D. (2024), Nature Medicine. 30, 8, p. 2170-2180
  • High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity

    Authors: Lee S., Weiss T., Bühler M., Mena J., Lottenbach Z., Wegmann R., Sun M., Bihl M., Augustynek B., Baumann S. P., Goetze S., van Drogen A., Pedrioli P. G., Penton D., Festl Y., Buck A., Kirschenbaum D., Zeitlberger A. M., Neidert M. C., Vasella F., Rushing E. J., Wollscheid B., Hediger M. A., Weller M. & Snijder B. (2024), Nature Medicine.
  • Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols

    Authors: Barboy O., Bercovich A., Li H., Lubling Y., Yalin A., Shapir Itai Y., Abadie K., Zada M., David E., Shlomi S., Katzenelenbogen Y., Adhemar D., Gur C., Yofe I., Feferman T., Cohen M., Dahan R., Newell E., Lifshitz A., Tanay A. & Amit I. (2024), Nature Cancer. 5, 5, p. 742-759
  • Sortilin in Biliary Epithelial Cells Promotes Ductular Reaction and Fibrosis during Cholestatic Injury

    Authors: Hubel E., Neumann A., Fishman S., Schaffer O., Erez N., Shrkihe B. A., Shteingard Y., Gross T., Shibolet O., Varol C. & Zvibel I. (2024), American Journal of Pathology.
  • p53: A tale of complexity and context

    Authors: Oren M. & Prives C. (2024),
  • Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ

    Authors: Yu Y., Farooq M. S., Eberhart Meessen S., Jiang Y., Kato D., Zhan T., Weiss C., Seger R., Kang W., Zhang X., Yu J., Ebert M. P. & Burgermeister E. (2024), Cell Death and Disease. 15, 1, 7
  • Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction

    Authors: Weidner P., Saar D., Söhn M., Schroeder T., Yu Y., Zöllner F. G., Ponelies N., Zhou X., Zwicky A., Rohrbacher F. N., Pattabiraman V. R., Tanriver M., Bauer A., Ahmed H., Ametamey S. M., Riffel P., Seger R., Bode J. W., Wade R. C., Ebert M. P., Kragelund B. B. & Burgermeister E. (2024), Cancer Letters. 588, 216783
  • Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts

    Authors: Agarwal H., Tal P., Goldfinger N., Chattopadhyay E., Malkin D., Rotter V. & Attery A. (2024), Cell Death and Differentiation. 31, 7, p. 855-867
  • Integrative spatial analysis reveals a multi-layered organization of glioblastoma

    Authors: Greenwald A. C., Darnell N. G., Hoefflin R., Simkin D., Mount C. W., Gonzalez Castro L. N., Harnik Y., Dumont S., Hirsch D., Nomura M., Talpir T., Kedmi M., Goliand I., Medici G., Laffy J., Li B., Mangena V., Keren-Shaul H., Weller M., Addadi Y., Neidert M. C., Suvà M. L. & Tirosh I. (2024), Cell. 187, 10, p. 2485-2501.e26
  • ATF3 characterizes aggressive drug-tolerant persister cells in HGSOC

    Authors: Böpple K., Oren Y., Henry W. S., Dong M., Weller S., Thiel J., Kleih M., Gaißler A., Zipperer D., Kopp H. G., Aylon Y., Oren M., Essmann F., Liang C. & Aulitzky W. E. (2024), Cell Death and Disease. 15, 290
  • Signaling lymphocytic activation molecule family receptors as potential immune therapeutic targets in solid tumors

    Authors: Gunes M., Rosen S. T., Shachar I. & Gunes E. G. (2024), Frontiers in Immunology. 15, 1297473
  • Loss of EIF4G2 mediates aggressiveness in distinct human endometrial cancer subpopulations with poor survival outcome in patients

    Authors: Meril S., Muhlbauer Avni M., Lior C., Bahlsen M., Olender T., Savidor A., Krausz J., Belhanes Peled H., Birisi H., David N., Bialik S., Scherz-Shouval R., Ben David Y. & Kimchi A. (2024), Oncogene. 43, 15, p. 1098-1112
  • Melanoma and microbiota: Current understanding and future directions

    Authors: Routy B., Jackson T., Mählmann L., Baumgartner C. K., Blaser M., Byrd A., Corvaia N., Couts K., Davar D., Derosa L., Hang H. C., Hospers G., Isaksen M., Kroemer G., Malard F., McCoy K. D., Meisel M., Pal S., Ronai Z., Segal E., Sepich-Poore G. D., Shaikh F., Sweis R. F., Trinchieri G., van den Brink M., Weersma R. K., Whiteson K., Zhao L., McQuade J., Zarour H. & Zitvogel L. (2024), Cancer Cell. 42, 1, p. 16-34
  • CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods

    Authors: Jain S., Bakolitsa C., Brenner S. E., Radivojac P., Moult J., Repo S., Hoskins R. A., Andreoletti G., Barsky D., Chellapan A., Chu H., Dabbiru N., Kollipara N. K., Ly M., Neumann A. J., Pal L. R., Odell E., Fishilevich S., Lancet D. & Yosef N. (2024), Genome Biology. 25, 1, 53
  • Computational pipeline predicting cell death suppressors as targets for cancer therapy

    Authors: Vinik Y., Maimon A., Mohan Raju H. R., Dubey V., Geist F., Wienke D. & Lev S. (2024), iScience. 27, 9, 110859
  • Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis

    Authors: Lambrecht R., Rudolf F., Ückert A. K., Sladky V. C., Phan T. S., Jansen J., Naim S., Kaufmann T., Keogh A., Kirschnek S., Mangerich A., Stengel F., Leist M., Villunger A. & Brunner T. (2024), Cell Death and Differentiation. 31, 1, p. 119-131
  • Tumor cells express and maintain HMGB1 in the reduced isoform to enhance CXCR4-mediated migration

    Authors: Pirani E., Paparoditis P., Pecoraro M., Danelon G., Thelen M., Cecchinato V. & Uguccioni M. (2024), Frontiers in Immunology. 15, 1358800
  • Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure

    Authors: Su M., Fleischer T., Grosheva I., Horev M. B., Olszewska M., Mattioli C. C., Barr H., Plotnikov A., Carvalho S., Moskovich Y., Minden M. D., Chapal-Ilani N., Wainstein A., Papapetrou E. P., Dezorella N., Cheng T., Kaushansky N., Geiger B. & Shlush L. I. (2024), iScience. 27, 4, 109443
  • Glucagon-like peptide-1 analogs activate AMP kinase leading to reversal of the Warburg metabolic switch in breast cancer cells

    Authors: Ligumsky H., Amir S., Arbel Rubinstein T., Guion K., Scherf T., Karasik A., Wolf I. & Rubinek T. (2024), Medical Oncology. 41, 6, 138
  • Keeping IPMNs in Check: A Novel Role for the Transcription Factor NKX6-2 in Preserving an Indolent Cell Identity in Pancreatic Cystic Lesions

    Authors: Ben-Shmuel A. & Scherz-Shouval R. (2023), Cancer Discovery. 13, 8, p. 1768-1770
  • The MAPK Signaling Cascades

  • PRC2-independent actions of H3.3K27M in embryonic stem cell differentiation

    Authors: Cohen L. R. Z., Kaffe B., Deri E., Leibson C., Nissim-Rafinia M., Maman M., Harpaz N., Ron G., Shema E. & Meshorer E. (2023), Nucleic Acids Research. 51, 4, p. 1662-1673
  • Cell lipid droplet heterogeneity and altered biophysical properties induced by cell stress and metabolic imbalance

    Authors: Ventura A. E., Pokorna S., Huhn N., Santos T. C., Prieto M., Futerman A. H. & Silva L. C. (2023), Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1868, 9, 159347
  • In Synergy: Optimizing CAR T Development and Personalizing Patient Care Using Single-Cell Technologies

    Authors: Barboy O., Katzenelenbogen Y., Shalita R. & Amit I. (2023), Cancer Discovery. 13, 7, p. 1546-1555
  • Polarization and motility of one-dimensional multi-cellular trains

    Authors: Ron J. E., d'Alessandro J., Cellerin V., Voituriez R., Ladoux B. & Gov N. S. (2023), Biophysical Journal. 122, 23, p. 4598-4613
  • Prevalence of MRI lesions in men responding to a GP-led invitation for a prostate health check: A prospective cohort study

    Authors: Moore C. M., Frangou E., McCartan N., Santaolalla A., Kopcke D., Brembilla G., Hadley J., Giganti F., Marsden T., Hemelrijck M. V., Gong F., Freeman A., Haider A., Tuck S., Pashayan N., Callender T., Green S., Brown L. C., Punwani S. & Domany E. (2023), BMJ Oncology. 2, 1, e000057
  • Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma

    Authors: Rosenberg M. I., Greenstein E., Buchkovich M., Peres A., Santoni-Rugiu E., Yang L., Mikl M., Vaksman Z., Gibbs D. L., Reshef D., Salovin A., Irwin M. S., Naranjo A., Ulitsky I., de Alarcon P. A., Matthay K. K., Weigman V., Yaari G., Panzer J. A., Friedman N. & Maris J. M. (2023), Cell Reports. 42, 8, 112879
  • A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy

    Authors: Stein-Thoeringer C. K., Saini N. Y., Zamir E., Blumenberg V., Schubert M. L., Mor U., Fante M. A., Schmidt S., Hayase E., Hayase T., Rohrbach R., Chang C. C., McDaniel L., Flores I., Gaiser R., Edinger M., Wolff D., Heidenreich M., Strati P., Nair R., Chihara D., Fayad L. E., Ahmed S., Iyer S. P., Steiner R. E., Jain P., Nastoupil L. J., Westin J., Arora R., Wang M. L., Turner J., Menges M., Hidalgo-Vargas M., Reid K., Dreger P., Schmitt A., Müller-Tidow C., Locke F. L., Davila M. L., Champlin R. E., Flowers C. R., Shpall E. J., Poeck H., Neelapu S. S., Schmitt M., Subklewe M., Jain M. D., Jenq R. R. & Elinav E. (2023), Nature Medicine. 29, 4, p. 906-916
  • Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets

    Authors: Beumers L., Vlachavas E. I., Borgoni S., Schwarzmüller L., Penso-Dolfin L., Michels B. E., Sofyali E., Burmester S., Heiss D., Wilhelm H., Yarden Y., Helm D., Will R., Goncalves A. & Wiemann S. (2023), NPJ Breast Cancer. 9, 1, 97
  • High-sensitivity deuterium metabolic MRI differentiates acute pancreatitis from pancreatic cancers in murine models

    Authors: Montrazi E. T., Sasson K., Agemy L., Peters D. C., Brenner O., Scherz A. & Frydman L. (2023), Scientific Reports. 13, 1, 19998
  • A clinical evaluation of an ex vivo organ culture system to predict patient response to cancer therapy

    Authors: Golan S., Bar V., Salpeter S. J., Neev G., Creiderman G., Kedar D., Aharon S., Turovsky L., Zundelevich A., Shahar H., Shapira H., Mallel G., Stossel E., Gavert N., Straussman R., Dotan Z., Berger R., Stossel C., Golan T., Halperin S., Leibovici D., Breuer S., Rottenberg Y., Applebaum L., Hubert A., Nechushtan H., Peretz T., Zick A., Chertin B., Koulikov D., Sonnenblick A. & Rosenbaum E. (2023), Frontiers in Medicine. 10, 1221484
  • Quantification of Invadopodia Formation and Matrix Degradation Activity

    Authors: Venghateri J. B. & Geiger B. (2023), Methods in Molecular Biology. p. 185-196
  • Early death after a diagnosis of metastatic solid cancerraising awareness and identifying risk factors from the SEER database

    Authors: Globus O., Sagie S., Lavine N., Barchana D. I. & Urban D. (2023), PLoS ONE. 18, 9, e0281561
  • Actin Filaments Couple the Protrusive Tips to the Nucleus through the I-BAR Domain Protein IRSp53 during the Migration of Cells on 1D Fibers

    Authors: Mukherjee A., Ron J. E., Hu H. T., Nishimura T., Hanawa-Suetsugu K., Behkam B., Mimori-Kiyosue Y., Gov N. S., Suetsugu S. & Nain A. S. (2023), Advanced Science. 10, 7, 2207368
  • Characterisation of knowledge of cancer, illness perceptions and their interaction among high-school students

    Authors: Haskel-Ittah M. & George-Levi S. (2023), International Journal of Science Education. 45, 9, p. 709-733
  • Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short-term vs long-term survivors of glioblastoma

    Authors: Ofek P., Yeini E., Arad G., Danilevsky A., Pozzi S., Luna C. B., Dangoor S. I., Grossman R., Ram Z., Shomron N., Brem H., Hyde T. M., Geiger T. & Satchi-Fainaro R. (2023), International Journal of Cancer. 153, 3, p. 654-668
  • Spatial profiling technologies illuminate the tumor microenvironment

    Authors: Elhanani O., Ben-Uri R. & Keren L. (2023), Cancer Cell. 41, 3, p. 404-420
  • C-terminal domain dimerization in yeast Hsp90 is moderately modulated by the other domains

    Authors: Oranges M., Giannoulis A., Vanyushkina A., Sirkis Y. F., Dalaloyan A., Unger T., Su X. C., Sharon M. & Goldfarb D. (2023), Biophysical Journal.
  • Definition of the contribution of an Osteopontin-producing CD11c+ microglial subset to Alzheimers disease

    Authors: Qiu Y., Shen X., Ravid O., Atrakchi D., Rand D., Wight A. E., Kim H. J., Liraz-Zaltsman S., Cooper I., Beeri M. S. & Cantor H. (2023), Proceedings of the National Academy of Sciences of the United States of America. 120, 6, e221891512
  • Phase II trial of hypomethylating agent combined with nivolumab for acute myeloid leukaemia relapse after allogeneic haematopoietic cell transplantationImmune signature correlates with response

    Authors: Apostolova P., Kreutmair S., Toffalori C., Punta M., Unger S., Burk A. C., Wehr C., Maas-Bauer K., Melchinger W., Haring E., Hoefflin R., Shoumariyeh K., Hupfer V., Lauer E. M., Duquesne S., Lowinus T., Gonzalo Núñez N., Alberti C., da Costa Pereira S., Merten C. H., Power L., Weiss M., Böke C., Pfeifer D., Marks R., Bertz H., Wäsch R., Ihorst G., Gentner B., Duyster J., Boerries M., Andrieux G., Finke J., Becher B., Vago L. & Zeiser R. (2023), British Journal of Haematology. 203, 2, p. 264-281
  • Author Correction: Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis (doi 10.1038/s41467-022-34863-9 , 28 Nov, 2022)

    Authors: Aylon Y., Furth N., Mallel G., Friedlander G., Nataraj N. B., Dong M., Hassin O., Zoabi R., Cohen B., Drendel V., Salame T. M., Mukherjee S., Harpaz N., Johnson R., Aulitzky W. E., Yarden Y., Shema E. & Oren M. (2023),
  • Distinct spatiotemporal features of microglia and monocyte-derived macrophages in glioma

    Authors: Banerjee K., Ratzabi A., Caspit I. M., Ganon O., Blinder P., Jung S. & Stein R. (2023), European Journal of Immunology. 53, 4, 2250161
  • L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

    Authors: Marrocco I., Giri S., Simoni-Nieves A., Gupta N., Rudnitsky A., Haga Y., Romaniello D., Sekar A., Zerbib M., Oren R., Lindzen M., Fard D., Tsutsumi Y., Lauriola M., Tamagnone L. & Yarden Y. (2023), Cell Reports Medicine. 4, 8, 101142
  • Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interaction

    Authors: Nuta G. C., Gilad Y., Goldberg N., Meril S., Bahlsen M., Carvalho S., Kozer N., Barr H., Fridmann Sirkis Y., Hercík K., Břehová P., Nencka R., Bialik S., Eisenstein M. & Kimchi A. (2023), Autophagy. 19, 8, p. 2372-2385
  • Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

    Authors: Dasgupta S., Dayagi D. Y., Haimovich G., Wyler E., Olender T., Singer R. H., Landthaler M. & Gerst J. E. (2023), eLife. 12, e83584
  • Large-Scale Immunopeptidome Analysis Reveals Recurrent Posttranslational Splicing of Cancer- and Immune-Associated Genes

    Authors: Levy R., Alter Regev T., Paes W., Gumpert N., Cohen Shvefel S., Bartok O., Dayan-Rubinov M., Alon M., Shmueli M., Levin Y., Merbl Y., Ternette N. & Samuels Y. (2023), Molecular and Cellular Proteomics. 22, 4, 100519
  • Arterial Thromboembolism in Patients With AF and CHA2DS2-VASc Score 0-2 With and Without Cancer

    Authors: Leader A., Mendelson Cohen N., Afek S., Jaschek R., Frajman A., Itzhaki Ben Zadok O., Raanani P., Lishner M. & Spectre G. (2023), JACC: CardioOncology. 5, 2, p. 174-185
  • Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours

    Authors: Gavish A., Tyler M., Greenwald A. C., Hoefflin R., Simkin D., Tschernichovsky R., Galili Darnell N., Somech E., Barbolin C., Antman T., Kovarsky D., Barrett T., Gonzalez Castro L. N., Halder D., Chanoch-Myers R., Laffy J., Mints M., Wider A., Tal R., Spitzer A., Hara T., Raitses-Gurevich M., Stossel C., Golan T., Tirosh A., Suvà M. L., Puram S. V. & Tirosh I. (2023), Nature. 618, 7965, p. 598-606
  • Shearing of surface mucin saps tumor cell strength

    Authors: Greenberg L. J. & Fass D. (2023), Trends in Pharmacological Sciences. 44, 11, p. 755-757
  • Probing lipids relaxation times in breast cancer using magnetic resonance spectroscopic fingerprinting

    Authors: Nissan N., Kulpanovich A., Agassi R., Allweis T., Haas I., Carmon E., Furman-Haran E., Anaby D., Sklair-Levy M. & Tal A. (2023), European Radiology. 33, p. 3744-3753
  • Proteomic signature for detection of high-grade ovarian cancer in germline BRCA mutation carriers

    Authors: Bahar-Shany K., Barnabas G. D., Deutsch L., Deutsch N., Glick-Saar E., Dominissini D., Sapoznik S., Helpman L., Perri T., Blecher A., Katz G., Yagel I., Rosenblatt O., Shai D., Brandt B., Meyer R., Mohr-Sasson A., Volodarsky-Perel A., Zilberman I., Armon S., Jakobson-Setton A., Eitan R., Kadan Y., Beiner M., Josephy D., Brodsky M., Friedman E., Anafi L., Molchanov Y., Korach J., Geiger T. & Levanon K. (2023), International Journal of Cancer. 152, 4, p. 781-793
  • Neoantigens in cancer immunotherapy: quantity vs. quality

    Authors: Wolf Y. & Sameuls Y. (2023), Molecular Oncology. 17, 8, p. 1457-1459
  • Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

    Authors: Kotsiliti E., Leone V., Schuehle S., Govaere O., Li H., Wolf M. J., Horvatic H., Bierwirth S., Hundertmark J., Inverso D., Zizmare L., Sarusi-Portuguez A., Gupta R., O'Connor T., Giannou A. D., Shiri A. M., Schlesinger Y., Beccaria M. G., Rennert C., Pfister D., Öllinger R., Gadjalova I., Ramadori P., Rahbari M., Rahbari N., Healy M. E., Fernández-Vaquero M., Yahoo N., Janzen J., Singh I., Fan C., Liu X., Rau M., Feuchtenberger M., Schwaneck E., Wallace S. J., Cockell S., Wilson-Kanamori J., Ramachandran P., Kho C., Kendall T. J., Leblond A. L., Keppler S. J., Bielecki P., Steiger K., Hofmann M., Rippe K., Zitzelsberger H., Weber A., Malek N., Luedde T., Vucur M., Augustin H. G., Flavell R., Parnas O., Rad R., Pabst O., Henderson N. C., Huber S., Macpherson A., Knolle P., Claassen M., Geier A., Trautwein C., Unger K., Elinav E., Waisman A., Abdullah Z., Haller D., Tacke F., Anstee Q. M. & Heikenwalder M. (2023), Journal of Hepatology. 79, 2, p. 296-313
  • MYC Induces Immunotherapy and IFNg Resistance Through Downregulation of JAK2

    Authors: Markovits E., Harush O., Baruch E. N., Shulman E. D., Debby A., Itzhaki O., Anafi L., Danilevsky A., Shomron N., Ben-Betzalel G., Asher N., Shapira-Frommer R., Schachter J., Barshack I., Geiger T., Elkon R., Besser M. J. & Markel G. (2023), Cancer Immunology Research. 11, 7, p. 909-924
  • MiR-142-3p is a Critical Modulator of TNF-mediated Neuronal Toxicity in Multiple Sclerosis

    Authors: De Vito F., Balletta S., Caioli S., Musella A., Guadalupi L., Vanni V., Fresegna D., Bassi M. S., Gilio L., Sanna K., Gentile A., Bruno A., Dolcetti E., Buttari F., Pavone L., Furlan R., Finardi A., Perlas E., Hornstein E., Centonze D. & Mandolesi G. (2023), Current Neuropharmacology. 21, 12, p. 2567-2582
  • Nanodot zirconium trisulfide based highly efficient biosensor for early diagnosis of lung cancer

    Authors: Shankar S., Kumar Y., Chauhan D., Tiwari P., Sharma N., Chandra R. & Kumar S. (2023), Microchemical Journal. 189, 108555
  • Redefining metalloproteases specificity through network proteolysis

    Authors: Kollet O., Das A., Karamanos N., auf dem Keller U. & Sagi I. (2023), Trends in Molecular Medicine.
  • Green Synthesis of Silver Nanoparticles Using the Leaf Extract of the Medicinal Plant, Uvaria narum and Its Antibacterial, Antiangiogenic, Anticancer and Catalytic Properties

    Authors: Ajaykumar A. P., Mathew A., Chandni A. P., Varma S. R., Jayaraj K. N., Sabira O., Rasheed V. A., Binitha V. S., Swaminathan T. R., Basheer V. S., Giri S. & Chatterjee S. (2023), Antibiotics. 12, 3, 564
  • Chemically programmable bacterial probes for the recognition of cell surface proteins

    Authors: Prasad P. K., Eizenshtadt N., Goliand I., Fellus-Alyagor L., Oren R., Golani O., Motiei L. & Margulies D. (2023), Materials Today Bio. 20, 100669
  • gUMI-BEAR, a modular, unsupervised population barcoding method to track variants and evolution at high resolution

    Authors: Rezenman S., Knafo M., Tsigalnitski I., Barad S., Jona G., Levi D., Dym O., Reich Z. & Kapon R. (2023), PLoS ONE. 18, 6, p. e0286696, e0286696
  • Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation

    Authors: Saltarin F., Wegmüller A., Bejarano L., Ildiz E. S., Zwicky P., Vianin A., Spadin F., Soukup K., Wischnewski V., Engelhardt B., Deutsch U., J. Marques I., Frenz M., Joyce J. A. & Lyck R. (2023), Cancers. 15, 20, 5071
  • Mutually communicated model based on multi-parametric MRI for automated segmentation and classification of prostate cancer

    Authors: Liu K., Li P., Otikovs M., Ning X., Xia L., Wang X., Yang L., Pan F., Zhang Z., Wu G., Xie H., Bao Q., Zhou X. & Liu C. (2023), Medical Physics. 50, 6, p. 3445-3458
  • Design, Synthesis, and Structural Insights of a Series of Zn(II)-NSAID Based Coordination Complex Derived Metallogels and Their Plausible Applications in Self Drug Delivery

    Authors: Biswas P., Dutta A. & Dastidar P. (2023), Crystal Growth and Design. 23, 1, p. 342-353
  • RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer

    Authors: Jbara A., Lin K. T., Stossel C., Siegfried Z., Shqerat H., Amar-Schwartz A., Elyada E., Mogilevsky M., Raitses-Gurevich M., Johnson J. L., Yaron T. M., Ovadia O., Jang G. H., Danan-Gotthold M., Cantley L. C., Levanon E. Y., Gallinger S., Krainer A. R., Golan T. & Karni R. (2023), Nature. 617, 7959, p. 147-153
  • Targeted delivery of tumor necrosis factor in combination with CCNU induces a T cell-dependent regression of glioblastoma

    Authors: Look T., Puca E., Bühler M., Kirschenbaum D., De Luca R., Stucchi R., Ravazza D., Di Nitto C., Roth P., Katzenelenbogen Y., Weiner A., Rindlisbacher L., Becher B., Amit I., Weller M., Neri D., Hemmerle T. & Weiss T. (2023), Science Translational Medicine. 15, 697, p. eadf2281, adf2281
  • RelaxationDiffusion T2ADC Correlations in Breast Cancer Patients: A Spatiotemporally Encoded 3T MRI Assessment

    Authors: Otikovs M., Nissan N., Furman-Haran E., Anaby D., Agassi R., Sklair-Levy M. & Frydman L. (2023), Diagnostics. 13, 23, 3516
  • The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors

    Authors: Dougherty M. W., Valdés-Mas R., Wernke K. M., Gharaibeh R. Z., Yang Y., Brant J. O., Riva A., Muehlbauer M., Elinav E., Puschhof J., Herzon S. B. & Jobin C. (2023), Neoplasia (United States). 43, 100918
  • EMSY stabilization in KEAP1-mutant lung cancer disrupts genome stability and type I interferon signaling

    Authors: Sheban D. & Merbl Y. (2023),
  • It takes two to tango: the role of tumor-associated macrophages in T cell-directed immune checkpoint blockade therapy

    Authors: Sheban F. (2023), Frontiers in Immunology. 14, 1183578
  • Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCAAssociated Pancreatic Cancer in the Clinical and Preclinical Setting

    Authors: Stossel C., Raitses-Gurevich M., Atias D., Beller T., Glick Gorman Y., Halperin S., Peer E., Denroche R. E., Zhang A., Notta F., Wilson J. M., O'Kane G. M., Haimov Talmoud E., Amison N., Schvimer M., Salpeter S. J., Bar V., Zundelevich A., Tirosh I., Tal R., Dinstag G., Kinar Y., Eliezer Y., Ben-David U., Gavert N. S., Straussman R., Gallinger S. J., Berger R. & Golan T. (2023), Cancer Discovery. 13, 8, p. 1826-1843
  • Multiplexed, single-molecule, epigenetic analysis of plasma-isolated nucleosomes for cancer diagnostics

    Authors: Fedyuk V., Erez N., Furth N., Beresh O., Andreishcheva E. N., Shinde A., Jones D., Bar Zakai B., Mavor Y., Peretz T., Hubert A., Cohen J., Salah A., Temper M., Grinshpun A., Maoz M., Zick A., Ron G. & Shema E. (2023), Nature Biotechnology. 41, 2, p. 212-221
  • Unanswered questions in prostate cancer - findings of an international multi-stakeholder consensus by the PIONEER consortium

    Authors: Omar M. I., MacLennan S., Ribal M. J., Roobol M. J., Dimitropoulos K., van den Broeck T., MacLennan S. J., Axelsson S. E., Gandaglia G., Willemse P., Mastris K., Ransohoff J. B., Devecseri Z., Abbott T., De Meulder B., Bjartell A., Asiimwe A., N'Dow J., Smith E., Lancet D. & Bernstein G. (2023), Nature Reviews Urology. 20, 8, p. 494-501
  • Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death

    Authors: Lambrecht R., Delgado M. E., Gloe V., Schuetz K., Plazzo A. P., Franke B., San Phan T., Fleming J., Mayans O. & Brunner T. (2023), Cell Reports. 42, 12, 113513
  • Clonal hematopoiesis in the donor does not adversely affect long-term outcomes following allogeneic hematopoietic stem cell transplantation: result from a 13-year follow-up

    Authors: Kim K. H., Kim T., Novitzky-Basso I., Lee H., Yoo Y., Ahn J., Pasic I., Law A., Lam W., Michelis F. V., Gerbitz A., Viswabandya A., Lipton J., Kumar R., Mattsson J., Zhang Z., Kaushansky N., Brilon Y., Chapal-Ilani N., Biezuner T., Shlush L. I. & Kim D. D. H. (2023), Haematologica. 108, 7, p. 1817-1826
  • The tumor microenvironment shows a hierarchy of cell-cell interactions dominated by fibroblasts

    Authors: Mayer S., Milo T., Isaacson A., Halperin C., Miyara S., Stein Y., Lior C., Pevsner-Fischer M., Tzahor E., Mayo A., Alon U. & Scherz-Shouval R. (2023), Nature Communications. 14, 1, 5810
  • CAR-T Cell Therapy and the Gut Microbiota

    Authors: Asokan S., Cullin N., Stein-Thoeringer C. K. & Elinav E. (2023), Cancers. 15, 3, 794
  • The landscape of T cell antigens for cancer immunotherapy

    Authors: Peri A., Salomon N., Wolf Y., Kreiter S., Diken M. & Samuels Y. (2023), Nature Cancer. 4, 7, p. 937-954
  • Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma

    Authors: Puram S. V., Mints M., Pal A., Qi Z., Reeb A., Gelev K., Barrett T. F., Gerndt S., Liu P., Parikh A. S., Ramadan S., Law T., Mroz E. A., Rocco J. W., Adkins D., Thorstad W. L., Gay H. A., Ding L., Paniello R. C., Pipkorn P., Jackson R. S., Wang X., Mazul A., Chernock R., Zevallos J. P., Silva-Fisher J. & Tirosh I. (2023), Nature Genetics. 55, 4, p. 640-650
  • Immunometabolism at the crossroads of obesity and cancera Keystone Symposia report

    Authors: Cable J., Rathmell J. C., Pearce E. L., Ho P. C., Haigis M. C., Mamedov M. R., Wu M. J., Kaech S. M., Lynch L., Febbraio M. A., Bapat S. P., Hong H. S., Zou W., Belkaid Y., Sullivan Z. A., Keller A., Wculek S. K., Green D. R., Postic C., Amit I., Benitah S. A., Jones R. G., Reina-Campos M., Torres S. V., Beyaz S., Brennan D., O'Neill L. A., Perry R. J. & Brenner D. (2023), Annals of the New York Academy of Sciences. 1523, 1, p. 38-50
  • Intracellular bacteria in cancerprospects and debates

    Authors: Schorr L., Mathies M., Elinav E. & Puschhof J. (2023), npj Biofilms and Microbiomes. 9, 76
  • Functional Impact of Protein-RNA Variation in Clinical Cancer Analyses

    Authors: Arad G. & Geiger T. (2023), Molecular & cellular proteomics : MCP. 22, 7, 100587
  • Depleting the 19S proteasome regulatory PSMD1 subunit as a cancer therapy strategy

    Authors: Adler J., Oren R. & Shaul Y. (2023), Cancer medicine (Malden, MA).
  • A Novel Modality Enables New Evidence-Based Individual Risk Stratification That Can Potentially Lead to Decisive Management and Treatment Decisions in Prostate Cancer

    Authors: Weksler M., Simon A., Lenkinski R. E., Landsman H., Matzkin H., Mabjeesh N. & Leibovitch I. (2023), Diagnostics. 13, 3, 424
  • The prognostic value of beta-1 blockers in patients with non-small-cell lung carcinoma treated with pembrolizumab

    Authors: Leshem Y., Etan T., Dolev Y., Nikolaevski-Berlin A., Miodovnik M., Shamai S., Merimsky O., Wolf I., Havakuk O., Tzuberi M., Topilsky Y., Banai S., Rozenbaum Z. & Laufer-Perl M. (2023), International Journal of Cardiology. 131642
  • Resistance of Lung Cancer to EGFR-Specific Kinase Inhibitors: Activation of Bypass Pathways and Endogenous Mutators

    Authors: Marrocco I. & Yarden Y. (2023), Cancers. 15, 20, 5009
  • Deuterium imaging of the Warburg effect at sub-millimolar concentrations by joint processing of the kinetic and spectral dimensions

    Authors: Montrazi E. T., Bao Q., Martinho R. P., Peters D. C., Harris T., Sasson K., Agemy L., Scherz A. & Frydman L. (2023), NMR in Biomedicine. 36, 11, e4995
  • Folylpolyglutamate synthetase mRNA G-quadruplexes regulate its cell protrusion localization and enhance a cancer cell invasive phenotype upon folate repletion

    Authors: Stark M., Levin M., Ulitsky I. & Assaraf Y. G. (2023), BMC Biology. 21, 1, 13
  • UV irradiation remodels the specificity landscape of transcription factors

    Authors: Mielko Z., Zhang Y., Sahay H., Liu Y., Schaich M. A., Schnable B., Morrison A. M., Burdinski D., Adar S., Pufall M., Van Houten B., Gordân R. & Afek A. (2023), Proceedings of the National Academy of Sciences of the United States of America. 120, 11, e221742212
  • A natural goldmine of binding proteins and soluble receptors simplified their translation to blockbuster drugs, all in one decade

    Authors: Novick D. (2023),
  • Glioma synapses recruit mechanisms of adaptive plasticity

    Authors: Taylor K. R., Barron T., Hui A., Spitzer A., Yalçin B., Ivec A. E., Geraghty A. C., Hartmann G. G., Arzt M., Gillespie S. M., Kim Y. S., Maleki Jahan S., Zhang H., Shamardani K., Su M., Ni L., Du P. P., Woo P. J., Silva-Torres A., Venkatesh H. S., Mancusi R., Ponnuswami A., Mulinyawe S., Keough M. B., Chau I., Aziz-Bose R., Tirosh I., Suvà M. L. & Monje M. (2023), Nature. 623, 7986, p. 366-374
  • Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology

    Authors: Bolshette N., Ibrahim H., Reinke H. & Asher G. (2023), Nature Reviews Gastroenterology and Hepatology. 20, 11, p. 695-707
  • Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation

    Authors: Venghateri J. B., Dassa B., Morgenstern D., Shreberk-Shaked M., Oren M. & Geiger B. (2023), Cell Death and Disease. 14, 4, 290
  • Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition

    Authors: Lax E., Do Carmo S., Enuka Y., Sapozhnikov D. M., Welikovitch L. A., Mahmood N., Rabbani S. A., Wang L., Britt J. P., Hancock W. W., Yarden Y. & Szyf M. (2023), Translational Psychiatry. 13, 1, 259
  • Fungi and cancer

    Authors: Saftien A., Puschhof J. & Elinav E. (2023), Gut. 72, 7, p. 1410-1425
  • Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures

    Authors: Bourgonje A. R., Andreu-Sánchez S., Vogl T., Hu S., Vich Vila A., Gacesa R., Leviatan S., Kurilshikov A., Klompus S., Kalka I. N., van Dullemen H. M., Weinberger A., Visschedijk M. C., Festen E. A., Faber K. N., Wijmenga C., Dijkstra G., Segal E., Fu J., Zhernakova A. & Weersma R. K. (2023), Immunity. 56, 6, p. 1393-1409.e6
  • Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary

    Authors: Yofe I., Shami T., Cohen N., Landsberger T., Sheban F., Stoler-Barak L., Yalin A., Phan T. S., Li B., Monteran L., Scharff Y., Giladi A., Elbaz M., David E., Gurevich-Shapiro A., Gur C., Shulman Z., Erez N. & Amit I. (2023), Cancer Discovery. 13, 12, p. 2610-2631
  • A Highly Sensitive Flow Cytometric Approach to Detect Rare Antigen-Specific T Cells: Development and Comparison to Standard Monitoring Tools

    Authors: Dror Levinsky M., Brenner B., Yalon M., Levi Z., Livneh Z., Cohen Z., Paz-Elizur T., Grossman R., Ram Z. & Volovitz I. (2023), Cancers. 15, 3, 574
  • The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC

    Authors: Javitt A., Shmueli M. D., Kramer M. P., Kolodziejczyk A. A., Cohen I. J., Radomir L., Sheban D., Kamer I., Litchfield K., Bab-Dinitz E., Zadok O., Neiens V., Ulman A., Wolf-Levy H., Eisenberg-Lerner A., Kacen A., Alon M., Rêgo A. T., Stacher-Priehse E., Lindner M., Koch I., Bar J., Swanton C., Samuels Y., Levin Y., da Fonseca P. C., Elinav E., Friedman N., Meiners S. & Merbl Y. (2023), Nature Cancer. 4, 5, p. 629-647
  • Paradoxical activation of chronic lymphocytic leukemia cells by ruxolitinib in vitro and in vivo

    Authors: Spaner D. E., Luo T. Y. X., Wang G., Schreiber G., Harari D. & Shi Y. (2023), Frontiers in Oncology. 13, 1043694
  • Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency

    Authors: Rein A., Geron I., Kugler E., Fishman H., Gottlieb E., Abramovich I., Giladi A., Amit I., Mulet-Lazaro R., Delwel R., Gröschel S., Levin-Zaidman S., Dezorella N., Holdengreber V., Rao T. N., Yacobovich J., Steinberg-Shemer O., Huang Q., Tan Y., Chen S., Izraeli S. & Birger Y. (2023), Haematologica. 108, 9, p. 2316-2330
  • Unifying design principles of endocrine gland mass and its regulatory circuits

    Authors: Raz M., Milo T., Kohanim Y. K., Karin O., Tendler A., Bar A., Glass D. S., Mayo A. & Alon U. (2023), BioRxiv.
  • Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling

    Authors: Marmor-Kollet N., Berkun V., Cummings G., Keren-Shaul H., David E., Addadi Y. & Schuldiner O. (2023), Cell Reports. 42, 2, 112117
  • Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy

    Authors: Cohen Saban N., Yalin A., Landsberger T., Salomon R., Alva A., Feferman T., Amit I. & Dahan R. (2023), Science immunology. 8, 81, eadd8005
  • PYK2, a hub of signaling networks in breast cancer progression

    Authors: Gil-Henn H., Girault J. A. & Lev S. (2023), Trends in Cell Biology. 34, 4, p. 312-326
  • Identification of Lung Cancer Biomarkers by Nanosensors Based on Titanium Carbide (Ti3C2Tx) MXenes

    Authors: Panigrahi P., Vovusha H., Pal Y., Bae H., Lee H., Kaewmaraya T., Nazir S., Shiddiky M. J. & Hussain T. (2023), ACS Applied Nano Materials. 6, 23, p. 22117-22127
  • Computational design of BclxL inhibitors that target transmembrane domain interactions

    Authors: Duart G., Elazar A., Weinstein J. Y., Gadea-Salom L., Ortiz-Mateu J., Fleishman S. J., Mingarro I. & Martinez-Gil L. (2023), Proceedings of the National Academy of Sciences of the United States of America. 120, 11, e221964812
  • Apoptotic cell death in diseaseCurrent understanding of the NCCD 2023

    Authors: Vitale I., Pietrocola F., Guilbaud E., Aaronson S. A., Abrams J. M., Adam D., Agostini M., Agostinis P., Alnemri E. S., Altucci L., Amelio I., Andrews D. W., Aqeilan R. I., Arama E., Baehrecke E. H., Balachandran S., Bano D., Barlev N. A., Bartek J., Bazan N. G., Becker C., Bernassola F., Bertrand M. J., Bianchi M. E., Blagosklonny M. V., Blander J. M., Blandino G., Blomgren K., Borner C., Bortner C. D., Bove P., Boya P., Brenner C., Broz P., Brunner T., Damgaard R. B., Calin G. A., Campanella M., Candi E., Carbone M., Carmona-Gutierrez D., Cecconi F., Chan F. K., Chen G. Q., Chen Q., Chen Y. H., Cheng E. H., Chipuk J. E., Cidlowski J. A., Ciechanover A., Ciliberto G., Conrad M., Cubillos-Ruiz J. R., Czabotar P. E., DAngiolella V., Daugaard M., Dawson T. M., Dawson V. L., De Maria R., De Strooper B., Debatin K. M., Deberardinis R. J., Degterev A., Del Sal G., Deshmukh M., Di Virgilio F., Diederich M., Dixon S. J., Dynlacht B. D., El-Deiry W. S., Elrod J. W., Engeland K., Fimia G. M., Galassi C., Ganini C., Garcia-Saez A. J., Garg A. D., Garrido C., Gavathiotis E., Gerlic M., Ghosh S., Green D. R., Greene L. A., Gronemeyer H., Häcker G., Hajnóczky G., Hardwick J. M., Haupt Y., He S., Heery D. M., Hengartner M. O., Hetz C., Hildeman D. A., Ichijo H., Inoue S., Jäättelä M., Janic A., Joseph B., Jost P. J., Kanneganti T. D., Karin M., Kashkar H., Kaufmann T., Kelly G. L., Kepp O., Kimchi A., Kitsis R. N., Klionsky D. J., Kluck R., Krysko D. V., Kulms D., Kumar S., Lavandero S., Lavrik I. N., Lemasters J. J., Liccardi G., Linkermann A., Lipton S. A., Lockshin R. A., López-Otín C., Luedde T., MacFarlane M., Madeo F., Malorni W., Manic G., Mantovani R., Marchi S., Marine J. C., Martin S. J., Martinou J. C., Mastroberardino P. G., Medema J. P., Mehlen P., Meier P., Melino G., Melino S., Miao E. A., Moll U. M., Muñoz-Pinedo C., Murphy D. J., Niklison-Chirou M. V., Novelli F., Núñez G., Oberst A., Ofengeim D., Opferman J. T., Oren M., Pagano M., Panaretakis T., Pasparakis M., Penninger J. M., Pentimalli F., Pereira D. M., Pervaiz S., Peter M. E., Pinton P., Porta G., Prehn J. H., Puthalakath H., Rabinovich G. A., Rajalingam K., Ravichandran K. S., Rehm M., Ricci J. E., Rizzuto R., Robinson N., Rodrigues C. M., Rotblat B., Rothlin C. V., Rubinsztein D. C., Rudel T., Rufini A., Ryan K. M., Sarosiek K. A., Sawa A., Sayan E., Schroder K., Scorrano L., Sesti F., Shao F., Shi Y., Sica G. S., Silke J., Simon H. U., Sistigu A., Stephanou A., Stockwell B. R., Strapazzon F., Strasser A., Sun L., Sun E., Sun Q., Szabadkai G., Tait S. W., Tang D., Tavernarakis N., Troy C. M., Turk B., Urbano N., Vandenabeele P., Vanden Berghe T., Vander Heiden M. G., Vanderluit J. L., Verkhratsky A., Villunger A., von Karstedt S., Voss A. K., Vousden K. H., Vucic D., Vuri D., Wagner E. F., Walczak H., Wallach D., Wang R., Wang Y., Weber A., Wood W., Yamazaki T., Yang H. T., Zakeri Z., Zawacka-Pankau J. E., Zhang L., Zhang H., Zhivotovsky B., Zhou W., Piacentini M., Kroemer G. & Galluzzi L. (2023), Cell Death and Differentiation. 30, 5, p. 1097-1154
  • Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids

    Authors: Ahmed A., Reinhold C., Breunig E., Phan T. S., Dietrich L., Kostadinova F., Urwyler C., Merk V. M., Noti M., Toja da Silva I., Bode K., Nahle F., Plazzo A. P., Koerner J., Stuber R., Menche C., Karamitopoulou E., Farin H. F., Gollob K. J. & Brunner T. (2023), Molecular Oncology. 17, 8, p. 1545-1566
  • TAZ facilitates breast tumor growth by promoting an immune-suppressive tumor microenvironment

    Authors: Gershoni A., Hassin O., Nataraj N. B., Baruch S., Avioz-Seligman A., Pirona A. C., Fellus-Alyagor L., Meir Salame T., Mukherjee S., Mallel G., Yarden Y., Aylon Y. & Oren M. (2023), Molecular Oncology. 17, 12, p. 2675-2693
  • Hepatitis C virus infects and perturbs liver stem cells

    Authors: Meyers N. L., Ashuach T., Lyons D. E., Khalid M. M., Simoneau C. R., Erickson A. L., Bouhaddou M., Nguyen T. T., Renuka Kumar G., Taha T. Y., Natarajan V., Baron J. L., Neff N., Zanini F., Mahmoudi T., Quake S. R., Krogan N. J., Cooper S., McDevitt T. C., Yosef N. & Ott M. (2023), mBio. 14, 6, 0131823
  • A single-molecule liquid biopsy for cancer diagnosis

    Authors: Shema E. (2023),
  • Tackling tumor complexity with single-cell proteomics

    Authors: Geiger T. (2023), Nature Methods. 20, 3, p. 324-326
  • Clinical trial links oncolytic immunoactivation to survival in glioblastoma

    Authors: Ling A. L., Solomon I. H., Landivar A. M., Nakashima H., Woods J. K., Santos A., Masud N., Fell G., Mo X., Yilmaz A. S., Grant J., Zhang A., Bernstock J. D., Torio E., Ito H., Liu J., Shono N., Nowicki M. O., Triggs D., Halloran P., Piranlioglu R., Soni H., Stopa B., Bi W. L., Peruzzi P., Chen E., Malinowski S. W., Prabhu M. C., Zeng Y., Carlisle A., Rodig S. J., Wen P. Y., Lee E. Q., Nayak L., Chukwueke U., Gonzalez Castro L. N., Dumont S. D., Batchelor T., Kittelberger K., Tikhonova E., Miheecheva N., Tabakov D., Shin N., Gorbacheva A., Shumskiy A., Frenkel F., Aguilar-Cordova E., Aguilar L. K., Krisky D., Wechuck J., Manzanera A., Matheny C., Tak P. P., Barone F., Kovarsky D., Tirosh I., Suvà M. L., Wucherpfennig K. W., Ligon K., Reardon D. A. & Antonio Chiocca E. (2023), Nature. 623, 7985, p. 157-166
  • Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis

    Authors: Goldman O., Adler L. N., Hajaj E., Croese T., Darzi N., Galai S., Tishler H., Ariav Y., Lavie D., Fellus-Alyagor L., Oren R., Kuznetsov Y., David E., Jaschek R., Stossel C., Singer O., Malitsky S., Barak R., Seger R., Erez N., Amit I., Tanay A., Saada A., Golan T., Rubinek T., Sang Lee J., Ben-Shachar S., Wolf I. & Erez A. (2023), Cancer Discovery. 13, 7, p. 1616-1635
  • Targeting ribosome biogenesis reinforces ERK-dependent senescence in pancreatic cancer

    Authors: Rowell M. C., Deschênes-Simard X., Lopes-Paciencia S., Le Calvé B., Kalegari P., Mignacca L., Fernandez-Ruiz A., Guillon J., Lessard F., Bourdeau V., Igelmann S., Duman A. M., Stanom Y., Kottakis F., Deshpande V., Krizhanovsky V., Bardeesy N. & Ferbeyre G. (2023), Cell Cycle. 22, 19, p. 2172-2193
  • Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy

    Authors: Ma G. & Lin W. (2023), Military Medical Research. 10, 20
  • Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis

    Authors: Light N., Layeghifard M., Attery A., Subasri V., Zatzman M., Anderson N. D., Hatkar R., Blay S., Chen D., Novokmet A., Fuligni F., Tran J., de Borja R., Agarwal H., Waldman L., Abegglen L. M., Albertson D., Finlay J. L., Hansford J. R., Behjati S., Villani A., Gerstung M., Alexandrov L. B., Somers G. R., Schiffman J. D., Rotter V., Malkin D. & Shlien A. (2023), Nature Communications. 14, 1, 77
  • p21 facilitates chronic lung inflammation via epithelial and endothelial cells

    Authors: Levi N., Papismadov N., Majewska J., Roitman L., Wigoda N., Eilam R., Tsoory M., Rotkopf R., Ovadya Y., Akiva H., Regev O. & Krizhanovsky V. (2023), Aging (Albany, NY.). 15, 7, p. 2395-2417
  • The C-terminal tail of CSNAP attenuates the CSN complex

    Authors: Füzesi-Levi M. G., Ben-Nissan G., Listov D., Fridmann Sirkis Y., Hayouka Z., Fleishman S. & Sharon M. (2023), Life Science Alliance. 6, 10, e202201634
  • Prostate lesions characterization using diffusion-weighted spatiotemporal encoded MRI: Feasibility and initial assessment

    Authors: Otikovs M., Portnoy O., Anaby D., Rosenzweig B., Nissan N. & Frydman L. (2023), Magnetic Resonance in Medicine. 90, 2, p. 643-654
  • How Well do Polygenic Risk Scores Identify Men at High Risk for Prostate Cancer? Systematic Review and Meta-Analysis

    Authors: Siltari A., Lönnerbro R., Pang K., Shiranov K., Asiimwe A., Evans-Axelsson S., Franks B., Kiran A., Murtola T. J., Schalken J., Steinbeisser C., Bjartell A., Auvinen A., N'Dow J., Smith E. J., Shepherd R., Ribal M., Mottet N., Moris L. & Lancet D. (2023), Clinical Genitourinary Cancer. 21, 2, p. 316.e1-316.e11
  • An Increase in Mucin2 Expression Is Required for Colon Cancer Progression Mediated by L1

    Authors: Saha A., Gavert N., Brabletz T. & Ben-Zeev A. (2023), International Journal of Molecular Sciences. 24, 17, 13418
  • Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis

    Authors: Tsitsou-Kampeli A., Suzzi S., Kenigsbuch M., Satomi A., Strobelt R., Singer O., Feldmesser E., Purnapatre M., Colaiuta S. P., David E., Cahalon L., Hahn O., Wyss-Coray T., Shaul Y., Amit I. & Schwartz M. (2023), Cell Reports Medicine. 4, 11, 101278
  • Integrative study of whole exome variation and expression in gingivo-buccal oral squamous cell carcinoma revealed alteration in TLR-activated MAP-Kinase signalling

    Authors: Singh R., Chattopadhyay E., Ray A., Roy R., Biswas N. K., Ghose S. & Roy B. (2023), Human Gene. 36, 201183
  • TRAF3 suppression encourages B cell recruitment and prolongs survival of microbiome-intact mice with ovarian cancer

    Authors: Zorea J., Motro Y., Mazor R. D., Carmi Y. K., Shulman Z., Mahajna J., Moran-Gilad J. & Elkabets M. (2023), Journal of Experimental and Clinical Cancer Research. 42, 1, 107
  • Clonal evolution of leukemia from G6PD studies

    Authors: Bacharach T. & Shlush L. I. (2023), Haematologica. 108, 12, p. 3191-3192
  • Trapping all ERBB ligands decreases pancreatic lesions in a murine model of pancreatic ductal adenocarcinoma

    Authors: Hedegger K., Blutke A., Hommel T., Auer K. E., Nataraj N. B., Lindzen M., Yarden Y. & Dahlhoff M. (2023), Molecular Oncology.
  • Insights into the co-evolution of epithelial cells and fibroblasts in the esophageal tumor microenvironment

    Authors: Lavon H. & Scherz-Shouval R. (2023), Cancer Cell. 41, 5, p. 826-828
  • Drugging p53 in cancer: one protein, many targets

    Authors: Hassin O. & Oren M. (2023), Nature reviews. Drug discovery. 22, 2, p. 127-144
  • The Actin Network Interfacing Diverse Integrin-Mediated Adhesions

    Authors: Geiger B., Boujemaa-Paterski R., Winograd-Katz S. E., Balan Venghateri J., Chung W. L. & Medalia O. (2023), Biomolecules. 13, 2, 294
  • Breast Cancer-Secreted Factors Promote Lung Metastasis by Signaling Systemically to Induce a Fibrotic Premetastatic Niche

    Authors: Cohen N., Mundhe D., Deasy S. K., Adler O., Ershaid N., Shami T., Levi-Galibov O., Wassermann R., Scherz-Shouval R. & Erez N. (2023), Cancer Research. 83, 20, p. 3354-3367
  • From gatekeepers to providers: regulation of immune functions by cancer-associated fibroblasts

    Authors: Arpinati L. & Scherz-Shouval R. (2023), Trends in Cancer. 9, 5, p. 421-443
  • αβ+/CD19+-depleted haploidentical stem cell transplantation for children with acute leukemia: Is there a protective effect of increased γδ+ T-cell content in the graft?

    Authors: Dadi G., Jacoby E., Adam E., Hutt D., Varda-Bloom N., Bielorai B. & Toren A. (2023), Pediatric Transplantation. 27, 5, e14531
  • Association between diabetes mellitus and reduced efficacy of pembrolizumab in nonsmall cell lung cancer

    Authors: Leshem Y., Dolev Y., Siegelmann-Danieli N., Sharman Moser S., Apter L., Chodick G., Nikolaevski-Berlin A., Shamai S., Merimsky O. & Wolf I. (2023), Cancer.
  • Capturing the diversity of protein modifications on presented tumor antigens

    Authors: Javitt A. & Merbl Y. (2023),
  • p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells

    Authors: Hassin O., Sernik M., Seligman A., Vogel F. C., Wellenstein M. D., Smollich J., Halperin C., Pirona A. C., Toledano L. N., Caballero C. D., Schlicker L., Salame T. M., Portuguez A. S., Aylon Y., Scherz-Shouval R., Geiger T., de Visser K. E., Schulze A. & Oren M. (2023), Proceedings of the National Academy of Sciences of the United States of America. 120, 52, e231146012
  • Final Results of a Phase i Trial of WST-11 (TOOKAD Soluble) Vascular-targeted Photodynamic Therapy for Upper Tract Urothelial Carcinoma

    Authors: Yip W., Sjoberg D. D., Nogueira L. M., Tracey A. T., Alvim R. G., Reisz P. A., Demac Q., Benfante N. E., Vanden Berg R. W., Kim K., Al-Ahmadie H., Lin O., Bochner B. H., Dalbagni G., Donat S. M., Pietzak E. J., Hakimi A. A., Solit D. B., Scherz A., Bajorin D. F. & Coleman J. A. (2023),
  • Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors

    Authors: Kacen A., Javitt A., Kramer M. P., Morgenstern D., Tsaban T., Shmueli M. D., Teo G. C., Leprevost F. d. V., Barnea E., Yu F., Admon A., Eisenbach L., Samuels Y., Schueler-Furman O., Levin Y., Nesvizhskii A. & Merbl Y. (2023), Nature Biotechnology. 41, 2, p. 239-251
  • The proteasome regulator PSME4 drives immune evasion and abrogates anti-tumor immunity in NSCLC

    Authors: Javitt A., Shmueli M., Kramer M., Kolodziejczyk A., Cohen I., Kamer I., Litchfield K., Bab-Dinitz E., Zadok O., Neiens V., Ulman A., Radomir L., Wolf-Levy H., Eisenberg-Lerner A., Kacen A., Alon M., Toste Rêgo A., Stacher-Priehse E., Lindner M., Koch I., Bar J., Swanton C., Samuels Y., Levin Y., da Fonseca P. C. A., Elinav E., Friedman N., Meiners S. & Merbl Y. (2023), bioArxiv.
  • Modulating the proliferative and cytotoxic properties of patient-derived TIL by a synthetic immune niche of immobilized CCL21 and ICAM1

    Authors: Yunger S., Geiger B., Friedman N., Besser M. J. & Adutler-Lieber S. (2023), Frontiers in Oncology. 13, 1116328
  • BBB opening by low pulsed electric fields, depicted by delayed-contrast MRI, enables efficient delivery of therapeutic doxorubicin doses into mice brains

    Authors: Cooper I., Last D., Ravid O., Rand D., Matsree E., Omesi L., Shemesh C., Liberman M., Zach L., Furman O., Daniels D., Liraz-Zaltsman S., Mardor Y. & Sharabi S. (2023), Fluids and Barriers of the CNS. 20, 1, 67
  • Impact of TP53 Genomic Alterations in Large B-Cell Lymphoma Treated With CD19-Chimeric Antigen Receptor T-Cell Therapy

    Authors: Shouval R., Alarcon Tomas A., Fein J. A., Flynn J. R., Markovits E., Mayer S., Olaide Afuye A., Alperovich A., Anagnostou T., Besser M. J., Batlevi C. L., Dahi P. B., Devlin S. M., Fingrut W. B., Giralt S. A., Lin R. J., Markel G., Salles G., Sauter C. S., Scordo M., Shah G. L., Shah N., Scherz-Shouval R., van den Brink M., Perales M. & Palomba M. L. (2022), Journal of Clinical Oncology. 40, 4, p. 369-381
  • Cancer and cell cycle

    Authors: Nair R. R. & Yadav S. S. (2022), Understanding Cancer. Jain B. & Pandey S. (eds.). p. 91-102
  • Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

    Authors: Sciacovelli M., Dugourd A., Jimenez L. V., Yang M., Nikitopoulou E., Costa A. S. H., Tronci L., Caraffini V., Rodrigues P., Schmidt C., Ryan D. G., Young T., Zecchini V. R., Rossi S. H., Massie C., Lohoff C., Masid M., Hatzimanikatis V., Kuppe C., Kramann R., Von Kriegsheim A., Gnanapragasam V., Warren A. Y., Stewart G. D., Erez A., Vanharanta S., Saez-Rodriguez J. & Frezza C. (2022), Nature Communications. 13, 1, 7830
  • Ets21C sustains a pro-regenerative transcriptional program in blastema cells of Drosophila imaginal discs

    Authors: Worley M. I., Everetts N. J., Yasutomi R., Chang R. J., Saretha S., Yosef N. & Hariharan I. K. (2022), Current Biology. 32, 15, p. 3350-3364.e6
  • T Cells Promote Metastasis by Regulating Extracellular Matrix Remodeling following Chemotherapy

    Authors: Haj-Shomaly J., Vorontsova A., Barenholz-Cohen T., Levi-Galibov O., Devarasetty M., Timaner M., Raviv Z., Cooper T. J., Soker S., Hasson P., Weihs D., Scherz-Shouval R. & Shaked Y. (2022), Cancer research (Chicago, Ill.). 82, 2, p. 278-291
  • Bispecific antibodies increase the therapeutic window of CD40 agonists through selective dendritic cell targeting

    Authors: Salomon R., Rotem H., Katzenelenbogen Y., Weiner A., Cohen Saban N., Feferman T., Amit I. & Dahan R. (2022), Nature Cancer. 3, p. 287-302
  • Next Generation CD40 Agonistic Antibodies for Cancer Immunotherapy

    Authors: Salomon R. & Dahan R. (2022), Frontiers in Immunology. 13, 940674
  • ICAM-1 on Breast Cancer Cells Suppresses Lung Metastasis but Is Dispensable for Tumor Growth and Killing by Cytotoxic T Cells

    Authors: Regev O., Kizner M., Roncato F., Dadiani M., Saini M., Castro-Giner F., Yajuk O., Kozlovski S., Levi N., Addadi Y., Golani O., Ben-Dor S., Granot Z., Aceto N. & Alon R. (2022), Frontiers in Immunology. 13, 849701
  • AKTs do not translocate to the nucleus upon stimulation but AKT3 can constitutively signal from the nuclear envelope

    Authors: Wainstein E., Maik-Rachline G., Blenis J. & Seger R. (2022), Cell Reports. 41, 10, 111733
  • Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through FcγR engagement and type I interferon signaling

    Authors: Yofe I., Landsberger T., Yalin A., Solomon I., Costoya C., Demane D. F., Shah M., David E., Borenstein C., Barboy O., Matos I., Peggs K. S., Quezada S. A. & Amit I. (2022), Nature Cancer. 3, p. 1336-1350
  • Cancer microbiome

    Authors: Zitvogel L., Straussman R., Sepich-Poore G. D., Knight R., Iliev I. D., Sears C. L., Bullman S., Jobin C. & Zarour H. M. (2022),
  • Tumor-reactive antibodies evolve from non-binding and autoreactive precursors

    Authors: Mazor R. D., Nathan N., Gilboa A., Stoler-Barak L., Moss L., Solomonov I., Hanuna A., Divinsky Y., Shmueli M. D., Hezroni H., Zaretsky I., Mor M., Golani O., Sabah G., Jakobson-Setton A., Yanichkin N., Feinmesser M., Tsoref D., Salman L., Yeoshoua E., Peretz E., Erlich I., Mendelson Cohen N., Gershoni J. M., Freund N., Merbl Y., Yaari G., Eitan R., Sagi I. & Shulman Z. (2022), Cell. 185, 7, p. 1208-1222
  • A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing

    Authors: Isaac R., Vinik Y., Mikl M., Nadav-Eliyahu S., Shatz-Azoulay H., Yaakobi A., DeForest N., Majithia A. R., Webster N. J., Shav-Tal Y., Elhanany E. & Zick Y. (2022), iScience. 25, 11, 105270
  • A new function for the serine protease HtrA2 in controlling radiation-induced senescence in cancer cells

    Authors: Hammer L., Levin-Salomon V., Yaeli-Slonim N., Weiss M., Dekel-Bird N. P., Olender T., Porat Z., Winograd-Katz S., Savidor A., Levin Y., Bialik S., Geiger B. & Kimchi A. (2022), Molecular Oncology. 16, 6
  • Elucidating the diversity of malignant mesenchymal states in glioblastoma by integrative analysis

    Authors: Chanoch-Myers R., Wider A., Suva M. L. & Tirosh I. (2022), Genome Medicine. 14, 1, 106
  • DestVI identifies continuums of cell types in spatial transcriptomics data

    Authors: Lopez R., Li B., Keren-Shaul H., Boyeau P., Kedmi M., Pilzer D., Jelinski A., Yofe I., David E., Wagner A., Ergen C., Addadi Y., Golani O., Ronchese F., Jordan M. I., Amit I. & Yosef N. (2022), Nature biotechnology. 40, 9, p. 1360-1369
  • Targeted Drug Delivery for the Treatment of Blood Cancers

    Authors: Jiang Y., Lin W. & Zhu L. (2022), Molecules (Basel, Switzerland). 27, 4, 1310
  • Beyond rare disorders: A new era for peroxisomal pathophysiology

    Authors: Zalckvar E. & Schuldiner M. (2022), Molecular Cell. 82, 12, p. 2228-2235
  • Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors

    Authors: Belugali Nataraj N., Noronha A., Lee J. S., Ghosh S., Mohan Raju H. R., Sekar A., Zuckerman B., Lindzen M., Tarcitano E., Srivastava S., Selitrennik M., Livneh I., Drago-Garcia D., Rueda O. M., Caldas C., Lev S., Geiger T., Ciechanover A., Ulitsky I., Seger R., Ruppin E. & Yarden Y. (2022), Cell Reports. 38, 8, 110418
  • Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis

    Authors: Aylon Y., Furth N., Mallel G., Friedlander G., Nataraj N. B., Dong M., Hassin O., Zoabi R., Cohen B., Drendel V., Salame T. M., Mukherjee S., Harpaz N., Johnson R., Aulitzky W. E., Yarden Y., Shema E. & Oren M. (2022), Nature Communications. 13, 1, 7199
  • Conjugated Detergent Micelles as a Platform for IgM Purification

    Authors: Dhandapani G., Wachtel E., Das I., Sheves M. & Patchornik G. (2022), Biotechnology and Bioengineering. 119, 7, p. 1997-2003
  • Pseudo-mutant P53 is a unique phenotype of DNMT3Amutated pre-leukemia

    Authors: Tuval A., Brilon Y., Azogy H., Moskovitz Y., Leshkowitz D., Salame T. M., Minden M. D., Tal P., Rotter V., Oren M., Kaushansky N. & Shlush L. I. (2022), Haematologica. 107, 11, p. 2548-2561
  • BREAst Cancer Personalised NuTrition (BREACPNT): dietary intervention in breast cancer survivors treated with endocrine therapy a protocol for a randomised clinical trial

    Authors: Rein M. S., Dadiani M., Godneva A., Bakalenik-Gavry M., Morzaev-Sulzbach D., Vachnish Y., Kolobkov D., Lotan-Pompan m., Weinberger A., Segal E. & Gal-Yam E. N. (2022), BMJ Open. 12, 11, e062498
  • Aptamer-Modified Au Nanoparticles: Functional Nanozyme Bioreactors for Cascaded Catalysis and Catalysts for Chemodynamic Treatment of Cancer Cells

    Authors: Ouyang Y., Fadeev M., Zhang P., Carmieli R., Li J., Sohn Y. S., Karmi O., Nechushtai R., Pikarsky E., Fan C. & Willner I. (2022), ACS Nano. 16, 11, p. 18232-18243
  • Mechanisms of immune activation and regulation: lessons from melanoma

    Authors: Kalaora S., Nagler A., Wargo J. A. & Samuels Y. (2022), Nature reviews. Cancer. 22, 4, p. 195-207
  • A necessary role for increased biglycan expression during L1mediated colon cancer progression

    Authors: Saha A., Cheriyamundath S., Kumar A., Gavert N., Brabletz T. & Ben-Ze'ev A. (2022), International Journal of Molecular Sciences. 23, 1, 445
  • Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions

    Authors: Kolodkin-Gal D., Roitman L., Ovadya Y., Azazmeh N., Assouline B., Schlesinger Y., Kalifa R., Horwitz S., Khalatnik Y., Hochner-Ger A., Imam A., Demma J. A., Winter E., Benyamini H., Elgavish S., Khatib A. A., Meir K., Atlan K., Pikarsky E., Parnas O., Dor Y., Zamir G., Ben-Porath I. & Krizhanovsky V. (2022), Gut. 71, 2, p. 345-355
  • Galectin-8, cytokines, and the storm

    Authors: Zick Y. (2022), Biochemical Society Transactions. 50, 1
  • Author Correction: Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability (Genome Biology, (2018), 19, 1, (37), 10.1186/s13059-018-1401-9)

    Authors: Galanos P., Pappas G., Polyzos A., Kotsinas A., Svolaki I., Giakoumakis N. N., Glytsou C., Pateras I. S., Swain U., Souliotis V. L., Georgakilas A. G., Geacintov N., Scorrano L., Lukas C., Lukas J., Livneh Z., Lygerou Z., Chowdhury D., Sørensen C. S., Bartek J. & Gorgoulis V. G. (2022),
  • ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells

    Authors: Fishman H., Madiwale S., Geron I., Bari V., Van Loocke W., Kirschenbaum Y., Ganmore I., Kugler E., Rein-Gil A., Friedlander G., Schiby G., Birger Y., Strehl S., Soulier J., Knoechel B., Ferrando A., Noy-Lotan S., Nagler A., Mulloy J. C., Van Vlierberghe P. & Izraeli S. (2022), Blood. 139, 3, p. 399-412
  • The industrial genomic revolution: A new era in neuroimmunology

    Authors: Shalita R. & Amit I. (2022), Neuron. 110, 21, p. 3429-3443
  • Stabilization of hESCs in two distinct substates along the continuum of pluripotency

    Authors: Dekel C., Morey R., Hanna J., Laurent L. C., Ben-Yosef D. & Amir H. (2022), iScience. 25, 12, 105469
  • NRas activity is regulated by dynamic interactions with nanoscale signaling clusters at the plasma membrane

    Authors: Yakovian O., Sajman J., Alon M., Arafeh R., Samuels Y. & Sherman E. (2022), iScience. 25, 11, 105282
  • Comparing Intraperitoneal and Intravenous Personalized ErbB2CAR-T for the Treatment of Epithelial Ovarian Cancer

    Authors: Deshet-Unger N., Horn G., Rawet-Slobodkin M., Waks T., Laskov I., Michaan N., Raz Y., Bar V., Zundelevich A., Aharon S., Turovsky L., Mallel G., Salpeter S., Neev G., Hollander K. S., Katz B. Z., Grisaru D. & Globerson Levin A. (2022), Biomedicines. 10, 9, 2216
  • Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant

    Authors: Eytan K., Versano Z., Oren R., Jacob-Hirsch J., Leitner M., Harmelin A., Rechavi G., Toren A., Paglin S. & Yalon M. (2022), Frontiers in Oncology. 12, 959133
  • Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression

    Authors: Porazzi P., Petruk S., Pagliaroli L., De Dominici M., Deming, 2nd D., Puccetti M. V., Kushinsky S., Kumar G., Minieri V., Barbieri E., Deliard S., Trizzino M., Gardini A., Canaani E., Palmisiano N., Porcu P., Ertel A., Fortina P., Eischen C. M., Mazo A. & Calabretta B. (2022), Cancer Research. 82, 3, p. 458-471
  • Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells

    Authors: Wallis N., Oberman F., Shurrush K., Germain N., Greenwald G., Gershon T., Pearl T., Abis G., Singh V., Singh A., Sharma A. K., Barr H. M., Ramos A., Spiegelman V. S. & Yisraeli J. K. (2022), RNA Biology. 19, 1, p. 26-43
  • De novo-designed transmembrane domains tune engineered receptor functions

    Authors: Elazar A., Chandler N. J., Davey A. S., Weinstein J. Y., Nguyen J. V., Trenker R., Cross R. S., Jenkins M. R., Call M. J., Call M. E. & Fleishman S. J. (2022), eLife. 11, e75660
  • DNA methylation landscape of tumor-associated macrophages reveals pathways, transcription factors, and prognostic value relevant to triple-negative breast cancer patients

    Authors: Hey J., Halperin C., Hartmann M., Mayer S., Schönung M., Lipka D. B., Scherz-Shouval R. & Plass C. (2022), International Journal of Cancer.
  • Space in cancer biology: its role and implications

    Authors: Fomitcheva-Khartchenko A., Kashyap A., Geiger T. & Kaigala G. V. (2022), Trends in Cancer. 8, 12, p. 1019-1032
  • Downregulation of the Tumor Suppressor TFF1 Is Required during Induction of Colon Cancer Progression by L1

    Authors: Saha A., Gavert N., Brabletz T. & Ben-Ze'ev A. (2022), Cancers. 14, 18, 4478
  • Di-genic inheritance of germline POLE and PMS2 pathogenic variants causes a unique condition associated with pediatric cancer predisposition

    Authors: Michaeli O., Ladany H., Erez A., Shachar S. B., Izraeli S., Lidzbarsky G., Basel-Salmon L., Biskup S., Maruvka Y. E., Toledano H. & Goldberg Y. (2022), Clinical Genetics. 101, 4, p. 442-447
  • A novel role for nucleolin in splice site selection

    Authors: Shefer K., Boulos A., Gotea V., Arafat M., Ben Chaim Y., Muharram A., Isaac S., Eden A., Sperling J., Elnitski L. & Sperling R. (2022), RNA Biology. 19, 1, p. 333-352
  • Smoking-induced microbial dysbiosis in health and disease

    Authors: Shapiro H., Goldenberg K., Ratiner K. & Elinav E. (2022), Clinical science (1979). 136, 18, p. 1371-1387
  • IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells

    Authors: Nachmias B., Khan D. H., Voisin V., Mer A. S., Thomas G. E., Segev N., St-Germain J., Hurren R., Gronda M., Botham A., Wang X., Maclean N., Seneviratne A. K., Duong N., Xu C., Arruda A., Orouji E., Algouneh A., Hakem R., Shlush L., Minden M. D., Raught B., Bader G. D. & Schimmer A. D. (2022), Leukemia. 36, 5, p. 1283-1295
  • Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer

    Authors: Lee W., Maaß M., Quach A., Poscic N., Prangley H., Pallott E., Kim J. L., Pierce J. S., Ogretmen B., Futerman A. H. & Thévenod F. (2022), The journal of Biological chemistry. 298, 2, 101492
  • Ex vivo organotypic cultures for synergistic therapy prioritization identify patient-specific responses to combined MEK and Src inhibition in colorectal cancer

    Authors: Gavert N., Zwang Y., Weiser R., Greenberg O., Halperin S., Jacobi O., Mallel G., Sandler O., Berger A. J., Stossel E., Rotin D., Grinshpun A., Kamer I., Barzs J., Pines G., Saidian D., Bar I., Golan S., Rosenbaum E., Nadu A., Ben-Ami E., Weitzen R., Nechushtan H., Golanz T., Brenner B., Nissan A., Margalitzs O., Hershkovitz D., Lahat G. & Straussman R. (2022), Nature Cancer. 3, 2, p. 219-231
  • Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution

    Authors: Yang D., Jones M. G., Naranjo S., Rideout W. M., Min K. H. (., Ho R., Wu W., Replogle J. M., Page J. L., Quinn J. J., Horns F., Qiu X., Chen M. Z., Freed-Pastor W. A., McGinnis C. S., Patterson D. M., Gartner Z. J., Chow E. D., Bivona T. G., Chan M. M., Yosef N., Jacks T. & Weissman J. S. (2022), Cell. 185, 11, p. 1905-1923.e25
  • Polyclonal antibody-induced downregulation of HER1/EGFR and HER2 surpasses the effect of combinations of specific registered antibodies

    Authors: Bergado-Báez G., Gonzalez Suarez N., García L. C., Pérez-Martínez D., Hernández-Fernández D. R., Fundora-Barrios T., Rodríguez-Álvarez A., Díaz-Ordaz G. D., Lindzen M., Yarden Y. & Sánchez-Ramírez B. (2022), Frontiers in Oncology. 12, 951267
  • H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape

    Authors: Furth N., Algranati D., Dassa B., Beresh O., Fedyuk V., Morris N., Kasper L. H., Jones D., Monje M., Baker S. J. & Shema E. (2022), Cell Reports. 39, 7, 110836
  • The intricate nature of senescence in development and cell plasticity

    Authors: Gal H., Majewska J. & Krizhanovsky V. (2022), Seminars in Cancer Biology. 87, p. 214-219
  • Compartmentalization of the host microbiome: how tumor microbiota shapes checkpoint immunotherapy outcome and offers therapeutic prospects

    Authors: Boesch M., Horvath L., Baty F., Pircher A., Wolf D., Spahn S., Straussman R., Tilg H. & Brutsche M. H. (2022), Journal for ImmunoTherapy of Cancer. 10, e005401
  • Stochastic transitions as a major source of cancer heterogeneity

    Authors: Tirosh I. (2022),
  • Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions

    Authors: Narunsky-Haziza L., Sepich-Poore G. D., Livyatan I., Asraf O., Martino C., Nejman D., Gavert N., Stajich J. E., Amit G., González A., Wandro S., Perry G., Ariel R., Meltser A., Shaffer J. P., Zhu Q., Balint-Lahat N., Barshack I., Dadiani M., Gal-Yam E. N., Patel S. P., Bashan A., Swafford A. D., Pilpel Y., Knight R. & Straussman R. (2022), Cell. 185, 20, p. 3789-3806
  • A coalition to healthe impact of the cardiac microenvironment

    Authors: Tzahor E. & Dimmeler S. (2022), Science. 377, 6610, 1059
  • Cancer-associated fibroblasts in the single-cell era

    Authors: Lavie D., Ben-Shmuel A., Erez N. & Scherz-Shouval R. (2022), Nature Cancer. 3, 7, p. 793-807
  • CD74 as a regulator of transcription in normal B cells

    Authors: David K., Friedlander G., Pellegrino B., Radomir L., Lewinsky H., Leng L., Bucala R., Becker-Herman S. & Shachar I. (2022), Cell Reports. 41, 5, 111572
  • An exercise-induced metabolic shield in distant organs blocks cancer progression and metastatic dissemination

    Authors: Sheinboim D., Parikh S., Manich P., Markus I., Dahan S., Parikh R., Stubbs E., Cohen G., Zemser-Werner V., Bell R. E., Arciniegas Ruiz S., Percik R., Brenner R., Leibou S., Vaknine H., Arad G., Gerber Y., Keinan Boker L., Shimony T., Goldstein N., Bikovski L., Constantini K., Labes S., Mordechai S., Doron H., Ionescu A., Ziv T., Nizri E., Choshen G., Eldar-Finkelman H., Tabach Y., Helman A., Ben-Eliyahu S., Erez N., Perlson E., Geiger T., Ben-Zvi D., Khaled M., Gepner Y. & Levy C. (2022), Cancer research (Chicago, Ill.). 82, 22, p. 4164-4178
  • Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis

    Authors: Kim J. L., Mestre B., Malitsky S., Itkin M., Kupervaser M. & Futerman A. H. (2022), The journal of Biological chemistry. 298, 4, 101735
  • It's all in the combination: decoding the epigenome for cancer research and diagnostics

    Authors: Furth N. & Shema E. (2022), Current Opinion in Genetics and Development. 73, 101899
  • Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells

    Authors: Viukov S., Shani T., Bayerl J., Aguilera-Castrejon A., Oldak B., Sheban D., Tarazi S., Stelzer Y., Hanna J. H. & Novershtern N. (2022), Stem Cell Reports. 17, 11, p. 2484-2500
  • Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas

    Authors: Harpaz N., Mittelman T., Beresh O., Griess O., Furth N., Salame T., Oren R., Fellus-Alyagor L., Harmelin A., Alexandrescu S., Marques J. G., Filbin M. G., Ron G. & Shema E. (2022), Molecular Cell. 82, 14, p. 2696-2713
  • Identification of the central intermediate in the extra-embryonic to embryonic endoderm transition through single-cell transcriptomics

    Authors: Rothová M. M., Nielsen A. V., Proks M., Wong Y. F., Riveiro A. R., Linneberg-Agerholm M., David E., Amit I., Trusina A. & Brickman J. M. (2022), Nature Cell Biology. 24, 6, p. 833-844
  • Cardiovascular Disease Among Patients With AML and CHIP-Related Mutations

    Authors: Calvillo-Argüelles O., Schoffel A., Capo-Chichi J., Abdel-Qadir H., Schuh A., Carrillo-Estrada M., Liu S., Gupta V., Schimmer A. D., Yee K., Shlush L. I., Natarajan P. & Thavendiranathan P. (2022), JACC CardioOncology. 4, 1, p. 38-49
  • Immunogenicity and safety of BNT162b2 mRNA vaccine booster in actively treated patients with cancer

    Authors: Ligumsky H., Dor H., Etan T., Golomb I. & Nikolaevski-Berlin A. (2022), The Lancet Oncology. 23, 2, p. 193-195
  • Aptamer-Functionalized Ce4+-Ion-Modified C-Dots: Peroxidase Mimicking Aptananozymes for the Oxidation of Dopamine and Cytotoxic Effects toward Cancer Cells

    Authors: Ouyang Y., Fadeev M., Zhang P., Carmieli R., Sohn Y. S., Karmi O., Qin Y., Chen X., Nechushtai R. & Willner I. (2022), ACS applied materials & interfaces. 14, 50, p. 55365-55375
  • Spatiotemporal Omics-Refining the landscape of precision medicine

    Authors: Zhang J., Yin J., Heng Y., Xie K., Chen A., Amit I., Bian X. & Xu X. (2022), Life Medicine. 1, 2, p. 84-102
  • On the development of a neoantigen vaccine for the prevention of Lynch Syndrome

    Authors: Solomon A., Alteber Z., Bassan D., Sharbi-Yunger A., Esbit S., Tzehoval E. & Eisenbach L. (2022), International Journal of Cancer. 151, 1, p. 107-119
  • The brain-immune ecosystem: Implications for immunotherapy in defeating neurodegenerative diseases

    Authors: Schwartz M., Abellanas M. A., Tsitsou-Kampeli A. & Suzzi S. (2022),
  • 5isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1

    Authors: Li X., Michels B. E., Tosun O. E., Jung J., Kappes J., Ibing S., Nataraj N. B., Sahay S., Schneider M., Wörner A., Becki C., Ishaque N., Feuerbach L., Heßling B., Helm D., Will R., Yarden Y., Müller-Decker K., Wiemann S. & Körner C. (2022), Journal of Experimental and Clinical Cancer Research. 41, 1, 190
  • Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins

    Authors: Mukherjee S., Maddalena M., Lü Y., Martinez S., Nataraj N. B., Noronha A., Sinha S., Teng K., Cohen-Kaplan V., Ziv T., Arandkar S., Hassin O., Chatterjee R., Pirona A., Shreberk-Shaked M., Gershoni A., Aylon Y., Elazar Z., Yarden Y., Schramek D. & Oren M. (2022), Proceedings of the National Academy of Sciences. 119, 17, e211964411
  • BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling

    Authors: Shaashua L., Ben-Shmuel A., Pevsner-Fischer M., Friedman G., Levi-Galibov O., Nandakumar S., Barki D., Nevo R., Brown L. E., Zhang W., Stein Y., Lior C., Kim H. S., Bojmar L., Jarnagin W. R., Lecomte N., Mayer S., Stok R., Bishara H., Hamodi R., Levy-Lahad E., Golan T., Porco J. A., Iacobuzio-Donahue C. A., Schultz N., Tuveson D. A., Lyden D., Kelsen D. & Scherz-Shouval R. (2022), Nature Communications. 13, 1, 6513
  • The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response

    Authors: Cohen M., Giladi A., Barboy O., Hamon P., Li B., Zada M., Gurevich-Shapiro A., Beccaria C. G., David E., Maier B. B., Buckup M., Kamer I., Deczkowska A., Le Berichel J., Bar J., Iannacone M., Tanay A., Merad M. & Amit I. (2022), Nature Cancer. 3, p. 303-317
  • Global DNA Methylation Analysis of Cancer-Associated Fibroblasts Reveals Extensive Epigenetic Rewiring Linked with RUNX1 Upregulation in Breast Cancer Stroma

    Authors: Halperin C., Hey J., Weichenhan D., Stein Y., Mayer S., Lutsik P., Plass C. & Scherz-Shouval R. (2022), Cancer Research. 82, 22, p. 4139-4152
  • Designing coordination polymers as multi-drug-self-delivery systems for tuberculosis and cancer therapy: in vitro viability and in vivo toxicity assessment

    Authors: Biswas P., Datta H. K. & Dastidar P. (2022), Biomaterials Science. 10, 21, p. 6201-6216
  • SmMIP-tools: a computational toolset for processing and analysis of single-molecule molecular inversion probes-derived data

    Authors: Medeiros J. J. F., Capo-Chichi J., Shlush L. I., Dick J. E., Arruda A., Minden M. D. & Abelson S. (2022), Bioinformatics. 38, 8, p. 2088-2095
  • Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism

    Authors: He C., Maniyar R. R., Avraham Y., Zappasodi R., Rusinova R., Newman W., Heath H., Wolchok J. D., Dahan R., Merghoub T. & Meyerson J. (2022), Science advances. 8, 8, eabm4552
  • Controls for Phylogeny and Robust Analysis in Pareto Task Inference

    Authors: Adler M., Tendler A., Hausser J., Korem Y., Szekely P., Bossel N., Hart Y., Karin O., Mayo A. & Alon U. (2022), Molecular Biology and Evolution. 39, 1, msab297
  • Actin filaments couple the protrusive tips to the nucleus through the I-BAR domain protein IRSp53 for migration of elongated cells on 1D fibers

    Authors: Mukherjee A., Ron J. E., Hu H. T., Nishimura T., Hanawa-Suetsugu K., Behkam B., Gov N. S., Suetsugu S. & Nain A. S. (2022), BioRxiv.
  • An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes

    Authors: Jaiswal A., Verma A., Dannenfelser R., Melssen M., Tirosh I., Izar B., Kim T., Nirschl C. J., Devi K. S. P., Olson W. C., Slingluff C. L., Engelhard V. H., Garraway L., Regev A., Minkis K., Yoon C. H., Troyanskaya O., Elemento O., Suárez-Fariñas M. & Anandasabapathy N. (2022), Cancer Cell. 40, 5, p. 524-544.e5
  • Anti-SARS-CoV-2 immunoadhesin remains effective against Omicron and other emerging variants of concern

    Authors: Cohen-Dvashi H., Weinstein J., Katz M., Ashkenazy-Eilon M., Mor Y., Shimon A., Achdout H., Tamir H., Israely T., Strobelt R., Shemesh M., Stoler-Barak L., Shulman Z., Paran N., Fleishman S. J. & Diskin R. (2022), iScience. 25, 10, 105193
  • Divergence of mutational signatures in association with breast cancer subtype

    Authors: Perry G., Dadiani M., Kahana-Edwin S., Pavlovski A., Markus B., Hornung G., Balint-Lahat N., Yosepovich A., Hout-Siloni G., Jacob-Hirsch J., Sklair-Levy M., Friedman E., Barshack I., Kaufman B., Gal-Yam E. N. & Paluch-Shimon S. (2022), Molecular Carcinogenesis. 61, 11, p. 1056-1070
  • A Functional Pre-Screening Platform for Identifying Points of Vulnerability in the Cell Death Map of Human Melanoma Tumors

    Authors: Dekel-Bird N. P., Bialik S., Itzhaki O., Meir Salame T., Yaeli-Slonim N., Levin-Salomon V., Dasari S. K., Besser M. & Kimchi A. (2022), Journal of Cancer Science and Clinical Therapeutics. 6, 1, p. 39-60
  • Interactive, integrated analysis of single-cell transcriptomic and phylogenetic data with PhyloVision

    Authors: Jones M. G., Rosen Y. & Yosef N. (2022), Cell Reports Methods. 2, 4, 100200
  • Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation

    Authors: Biram A., Liu J., Hezroni-Bravyi H., Davidzohn N., Schmiedel D., Khatib-Massalha E., Haddad M., Grenov C. A., Lebon S., Salame T. M., Dezorella N., Hoffman D., Abou Karam P., Biton M., Lapidot T., Bemark M., Avraham R., Jung S. & Shulman Z. (2022), Immunity. 55, 3, p. 442-458.e8
  • Multi-NSAID-based Zn(

    Authors: Biswas P., Datta H. K. & Dastidar P. (2022), Chemical Communications. 58, 7, p. 969-972
  • Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients

    Authors: Hassin O., Nataraj N. B., Shreberk-Shaked M., Aylon Y., Yaeger R., Fontemaggi G., Mukherjee S., Maddalena M., Avioz A., Iancu O., Mallel G., Gershoni A., Grosheva I., Feldmesser E., Ben-Dor S., Golani O., Hendel A., Blandino G., Kelsen D., Yarden Y. & Oren M. (2022), Nature Communications. 13, 1, 2800
  • MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis

    Authors: Alborzinia H., Flórez A. F., Kreth S., Brückner L. M., Yildiz U., Gartlgruber M., Odoni D. I., Poschet G., Garbowicz K., Shao C., Klein C., Meier J., Zeisberger P., Nadler-Holly M., Ziehm M., Paul F., Burhenne J., Bell E., Shaikhkarami M., Würth R., Stainczyk S. A., Wecht E. M., Kreth J., Büttner M., Ishaque N., Schlesner M., Nicke B., Stresemann C., Llamazares-Prada M., Reiling J. H., Fischer M., Amit I., Selbach M., Herrmann C., Wölfl S., Henrich K., Höfer T., Trumpp A. & Westermann F. (2022), Nature Cancer. 3, 4, p. 471-485
  • Visual barcodes for clonal-multiplexing of live microscopy-based assays

    Authors: Kaufman T., Nitzan E., Firestein N., Ginzberg M. B., Iyengar S., Patel N., Ben-Hamo R., Porat Z., Hunter J., Hilfinger A., Rotter V., Kafri R. & Straussman R. (2022), Nature Communications. 13, 1, 2725
  • Whole-exome sequencing of HPV positive tonsillar and base of tongue squamous cell carcinomas reveals a global mutational pattern along with relapse-specific somatic variants

    Authors: Ährlund-Richter A., Holzhauser S., Dalianis T., Näsman A. & Mints M. (2022), Cancers. 14, 1, 77
  • Early antitumor activity of oral Langerhans cells is compromised by a carcinogen

    Authors: Saba Y., Aizenbud I., Matanes D., Koren N., Barel O., Zubeidat K., Capucha T., David E., Eli-Berchoer L., Stoitzner P., Wilensky A., Amit I., Czerninski R., Yona S. & Hovav A. (2022), Proceedings of the National Academy of Sciences of the United States of America. 119, 3, e211842411
  • Nine receptors and binding proteins, four drugs, and one woman: Historical and personal perspectives

    Authors: Novick D. (2022), Frontiers in Drug Discovery. 2, 1001487
  • Genetic insight into BirtHoggDubé syndrome in Indian patients reveals novel mutations at FLCN

    Authors: Ray A., Chattopadhyay E., Singh R., Ghosh S., Bera A., Sarma M., Munot M., Desai U., Rajan S., Prabhudesai P., Prakash A. K., Roy Chowdhury S., Bhowmick N., Dhar R., Udwadia Z. F., Dey A., Mitra S., Joshi J. M., Maitra A. & Roy B. (2022), Orphanet Journal of Rare Diseases. 17, 1, 176
  • Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma

    Authors: Risom T., Glass D. R., Averbukh I., Liu C. C., Baranski A., Kagel A., McCaffrey E. F., Greenwald N. F., Rivero-Gutierrez B., Strand S. H., Varma S., Kong A., Keren L., Srivastava S., Zhu C., Khair Z., Veis D. J., Deschryver K., Vennam S., Maley C., Hwang E. S., Marks J. R., Bendall S. C., Colditz G. A., West R. B. & Angelo M. (2022), Cell. 185, 2, p. 299-310.e18
  • DOP53 In-depth characterisation of the serum antibody epitope repertoire in Inflammatory Bowel Disease by high-throughput phage-displayed immunoprecipitation sequencing

    Authors: Bourgonje A. R., Andreu-Sánchez S., Vogl T., Hu S., Vich Vila A., Leviatan S., Kurilshikov A., Klompus S., Kalka I. N., van Dullemen H. M., Weinberger A., Visschedijk M. C., Festen E. A. M., Faber K. N., Wijmenga C., Dijkstra G., Segal E., Fu J., Zhernakova A. & Weersma R. K. (2022), Journal of Crohn's and Colitis. 16, Supplement_1, p. i100-i102
  • CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia

    Authors: Thavayogarajah T., Sinitski D., El Bounkari O., Torres-Garcia L., Lewinsky H., Harjung A., Chen H., Panse J., Vankann L., Shachar I., Bernhagen J. & Koschmieder S. (2022), Experimental Hematology. 115, p. 30-43
  • AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer

    Authors: Noronha A., Belugali Nataraj N., Sang Lee J., Zhitomirsky B., Oren Y., Oster S., Lindzen M., Mukherjee S., Will R., Ghosh S., Simoni-Nieves A., Verma A., Chatterjee R., Borgoni S., Robinson W., Sinha S., Brandis A., Kerr D. L., Wu W., Sekar A., Giri S., Chung Y., Drago-Garcia D., Danysh B. P., Lauriola M., Fiorentino M., Ardizzoni A., Oren M., Blakely C. M., Ezike J., Wiemann S., Parida L., Bivona T. G., Aqeilan R. I., Brugge J. S., Regev A., Getz G., Ruppin E. & Yarden Y. (2022), Cancer Discovery. 12, 11, p. 2666-2683
  • Characteristics & outcomes of cancer patients with COVID-19: A multicentre retrospective study from India

    Authors: Kumar A., Baghmar S., Mehta P., Tiwari P., Kumar L., Bakhshi S., Agarwal A., Gupta I., Trikha A., Bhatnagar S., Gogia A., Malik P. S., Sahoo R. K., Rastogi S., Pramanik R., Batra A., Pushpam D., Sharma C. K., Sharma V., Kataria B., Goyal K., Samaga S., Bothra S. J. & Sharma A. (2022), Indian Journal of Medical Research. 155, 5-6, p. 546-553
  • Structure-guided design and characterization of a clickable, covalent PARP16 inhibitor

    Authors: Bejan D. S., Sundalam S., Jin H., Morgan R. K., Kirby I. T., Siordia I. R., Tivon B., London N. & Cohen M. S. (2022), Chemical science (Cambridge). 13, 46, p. 13898-13906
  • Blockade of the protease ADAM17 ameliorates experimental pancreatitis

    Authors: Saad M. I., Weng T., Lundy J., Gearing L. J., West A. C., Harpur C. M., Alanazi M., Hodges C., Croagh D., Kumar B., Sagi I., Rose-John S. & Jenkins B. J. (2022), Proceedings of the National Academy of Sciences. 119, 42, e221374411
  • Brain metastases: Not all tumors are created equal

    Authors: Kirschenbaum D. & Amit I. (2022),
  • Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues

    Authors: Crawford D. R., Sinha S., Nair N. U., Ryan B. M., Barnholtz-Sloan J. S., Mount S. M., Erez A., Aldape K., Castle P. E., Rajagopal P. S., Day C., Schäffer A. A. & Ruppin E. (2022), Cancers. 14, 23, 5885
  • Expert survey on management of prostate cancer in India: Real-world insights into practice patterns

    Authors: Bakshi G., Tongaonkar H., Addla S., Menon S., Pradhan A., Kumar A., Bapat A., Gore A., Joshi A., Raja A., Bradoo A., Ramesh A., Kumar A., Agrawal A., Ambekar A., Joshi A., Singh A., Singh B. P., Dabkara D., Khadakban D., Gautam G., Prakash G., Pahwa H. S., Goel H. K., Kulkarni J., Mishra J. J., Patel K., Pal M., Chibber P. J., Tiwari P., Naik R., Raghunath S. K., Krishnatry R., Shimpi R., Sharma R., Taran R., Trivedi S., Nabar S., Surekha S., Kumar S., Sawaimoon S. K., Raina S., Narasimha S., Advani S., Ghouse S. M., Muddu V. K., Maniar V., Venkat V. & Murthy V. (2022), Indian Journal of Cancer. 59, 5, p. S19-S45
  • A spatial perspective on bacteria in tumours

    Authors: Livyatan I. & Straussman R. (2022), Nature. 611, 7937, p. 674-675
  • Spaceflight-Associated Changes of snoRNAs in Peripheral Blood Mononuclear Cells and Plasma ExosomesA Pilot Study

    Authors: Rai A. K., Rajan K. S., Bisserier M., Brojakowska A., Sebastian A., Evans A. C., Coleman M. A., Mills P. J., Arakelyan A., Uchida S., Hadri L., Goukassian D. A. & Garikipati V. N. S. (2022), Frontiers in Cardiovascular Medicine. 9, 886689
  • Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer

    Authors: Salaroglio I. C., Belisario D. C., Akman M., La Vecchia S., Godel M., Anobile D. P., Ortone G., Digiovanni S., Fontana S., Costamagna C., Rubinstein M., Kopecka J. & Riganti C. (2022), Journal of Experimental and Clinical Cancer Research. 41, 1, 243
  • Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

    Authors: Ogran A., Havkin-Solomon T., Becker-Herman S., David K., Shachar I. & Dikstein R. (2022), eLife. 11, e77714
  • A similarity-based method for predicting enzymatic functions in yeast uncovers a new AMP hydrolase

    Authors: Cohen N., Kahana A. & Schuldiner M. (2022), Journal of Molecular Biology. 434, 7, 167478
  • S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair

    Authors: Amar-Schwartz A., Ben Hur V., Jbara A., Cohen Y., Barnabas G. D., Arbib E., Siegfried Z., Mashahreh B., Hassouna F., Shilo A., Abu-Odeh M., Berger M., Wiener R., Aqeilan R., Geiger T. & Karni R. (2022), eLife. 11, e79128
  • Spatial organization and early signaling of the B-cell receptor in CLL

    Authors: Arbel Y. S., Bronstein Y., Dadosh T., Kamdjou T., Tsuriel S., Shapiro M., Katz B. & Herishanu Y. (2022), Frontiers in Immunology. 13, 953660
  • Mouse Modeling Dissecting MacrophageBreast Cancer Communication Uncovered Roles of PYK2 in Macrophage Recruitment and Breast Tumorigenesis

    Authors: Muller A., Kohler U. A., Trzebanski S., Vinik Y., Mohan Raju H. R., Girault J., Ben-Chetrit N., Maraver A., Jung S. & Lev S. (2022), Advanced Science. 9, 9, 2105696
  • Intratumor heterogeneity and anti-tumor immunity shape one another bidirectionally

    Authors: Wolf Y. & Samuels Y. (2022), Clinical Cancer Research. 28, 14, p. 2994-3001
  • Germline genetic biomarkers to stratify patients for personalized radiation treatment

    Authors: Deichaite I., Hopper A., Krockenberger L., Sears T. J., Sutton L., Ray X., Sharabi A., Navon A., Sanghvi P., Carter H. & Moiseenko V. (2022), Journal of Translational Medicine. 20, 1, 360
  • The microbiome and human cancer

    Authors: Sepich-Poore G. D., Zitvogel L., Straussman R., Hasty J., Wargo J. A. & Knight R. (2021), Science. 371, 6536, eabc4552
  • Single Instillation of Hypertonic Saline Immediately Following Transurethral Resection of Bladder Tumor for Recurrence Prevention A Phase I Study

    Authors: Modai J., Kovalyonok A., Scherz A., Preise D., Avda Y., Shpunt I., Sasson K., Jaber M., Peretz Y., Croock R., Shilo Y., Ikher S., Lindner U. & Leibovici D. (2021), Bladder Cancer. 7, 2, p. 187-192
  • The myeloid sarcoma treated by Venetoclax with hypomethylating agent followed by stem cell transplantation: rare case report

    Authors: Shatilova A., Girshova L., Zaytsev D., Budaeva I., Mirolyubova Y., Ryzhkova D., Grozov R., Bogdanov K., Nikulina T., Motorin D., Zammoeva D., Efremova S., Ivanov V., Petukhov A., Alekseeva Y. & Zaritskey A. (2021), BMC Women's Health. 21, 1, 184
  • Albumin-EDTA-Vanadium Is a Powerful Anti-Proliferative Agent, Following Entrance into Glioma Cells via Caveolae-Mediated Endocytosis

    Authors: Cooper I., Ravid O., Rand D., Atrakchi D., Shemesh C., Bresler Y., Ben-Nissan G., Sharon M., Fridkin M. & Shechter Y. (2021), Pharmaceutics. 13, 10, 1557
  • Identification of variable stages in murine pancreatic tumors by a multiparametric approach employing hyperpolarized 13C MRSI, 1H diffusivity and 1H T1 MRI

    Authors: Martinho R. P., Bao Q., Markovic S., Preise D., Sasson K., Agemy L., Scherz A. & Frydman L. (2021), NMR in Biomedicine. 34, 2, 4446
  • Improving deuterium metabolic imaging (DMI) signaltonoise ratio by spectroscopic multiecho bSSFP: A pancreatic cancer investigation

    Authors: Peters D. C., Markovic S., Bao Q., Preise D., Sasson K., Agemy L., Scherz A. & Frydman L. (2021), Magnetic Resonance in Medicine. 86, 5, p. 2604-2617
  • TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment

    Authors: Maddalena M., Mallel G., Nataraj N. B., Shreberk-Shaked M., Hassin O., Mukherjee S., Arandkar S., Rotkopf R., Kapsack A., Lambiase G., Pellegrino B., Ben-Isaac E., Golani O., Addadi Y., Hajaj E., Eilam R., Straussman R., Yarden Y., Lotem M. & Oren M. (2021), Proceedings of the National Academy of Sciences. 118, 23, e202563111
  • Conformational switches and redox properties of the colon cancerassociated human lectin ZG16

    Authors: Javitt G., Kinzel A., Reznik N. & Fass D. (2021), The FEBS journal. 288, 22, p. 6465-6475
  • Constitutive low expression of antiviral effectors sensitizes melanoma cells to a novel oncolytic virus

    Authors: Dellac S., Ben-Dov H., Raanan A., Saleem H., Zamostiano R., Semyatich R., Lavi S., Witz I. P., Bacharach E. & Ehrlich M. (2021), International Journal of Cancer. 148, 9, p. 2321-2334
  • Vascular-Targeted Photodynamic Therapy for Prostate Cancer

  • Structured elements drive extensive circular RNA translation

    Authors: Chen C. K., Cheng R., Demeter J., Chen J., Weingarten-Gabbay S., Jiang L., Snyder M. P., Weissman J. S., Segal E., Jackson P. K. & Chang H. Y. (2021), Molecular Cell. 81, 20, p. 4300-4318.e13
  • Decoding cancer biology one cell at a time

    Authors: Gonzalez Castro L. N., Tirosh I. & Suvà M. L. (2021), Cancer Discovery. 11, 4, p. 960-970
  • Learned Super Resolution Ultrasound for Improved Breast Lesion Characterization

    Authors: Bar-Shira O., Grubstein A., Rapson Y., Suhami D., Atar E., Peri-Hanania K., Rosen R. & Eldar Y. C. (2021), Medical Image Computing and Computer Assisted Intervention MICCAI 2021. p. 109-118
  • Melanoma models for the next generation of therapies

    Authors: Patton E. E., Mueller K. L., Adams D. J., Anandasabapathy N., Aplin A. E., Bertolotto C., Bosenberg M., Ceol C. J., Chi P., Herlyn M., Holmen S. L., Karreth F. A., Kaufman C. K., Khan S., Kobold S., Leucci E., Levy C., Lombard D. B., Lund A. W., Marie K. L., Marine J. C., Marais R., McMahon M., Robles-Espinoza C. D., Ronai Z. A., Samuels Y., Soengas M. S., Villanueva J., Weeraratna A. T., White R. M., Yeh I., Zhu J., Zon L. I., Hurlbert M. S. & Merlino G. (2021), Cancer Cell. 39, 5, p. 610-631
  • Spatially organized multicellular immune hubs in human colorectal cancer

    Authors: Pelka K., Hofree M., Chen J. H., Sarkizova S., Pirl J. D., Jorgji V., Bejnood A., Dionne D., Ge W. H., Xu K. H., Chao S. X., Zollinger D. R., Lieb D. J., Reeves J. W., Fuhrman C. A., Hoang M. L., Delorey T., Nguyen L. T., Waldman J., Wakiro I., Klapholz M., Cohen O., Albers J., Smillie C. S., Cuoco M. S., Wu J., Su M., Yeung J., Vijaykumar B., Magnuson A. M., Asinovski N., Moll T., Goder-Reiser M. N., Applebaum A. S., Brais L. K., DelloStritto L. K., Denning S. L., Phillips S. T., Hill E. K., Meehan J. K., Frederick D. T., Sharova T., Kanodia A., Todres E. Z., Jané-Valbuena J., Biton M., Izar B., Lambden C. D., Clancy T. E., Bleday R., Melnitchouk N., Irani J., Kunitake H., Berger D. L., Srivastava A., Hornick J. L., Ogino S., Rotem A., Vigneau S., Johnson B. E., Corcoran R. B., Sharpe A. H., Kuchroo V. K., Ng K., Giannakis M., Nieman L. T., Boland G. M., Aguirre A. J., Anderson A. C., Rozenblatt-Rosen O., Regev A. & Hacohen N. (2021), Cell. 184, 18, p. 4734-4752.e20
  • Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans

    Authors: Gordin M., Philip H., Zilberberg A., Gidoni M., Margalit R., Clouser C., Adams K., Vigneault F., Cohen I. R., Yaari G. & Efroni S. (2021), PLoS Computational Biology. 17, 1, 1008486
  • Identification of bacteria-derived HLA-bound peptides in melanoma

    Authors: Kalaora S., Nagler A., Nejman D., Alon M., Barbolin C., Barnea E., Ketelaars S. L. C., Cheng K., Vervier K., Shental N., Bussi Y., Rotkopf R., Levy R., Benedek G., Trabish S., Dadosh T., Levin-Zaidman S., Geller L. T., Wang K., Greenberg P., Yagel G., Peri A., Fuks G., Bhardwaj N., Reuben A., Hermida L., Johnson S. B., Galloway-Peña J. R., Shropshire W. C., Bernatchez C., Haymaker C., Arora R., Roitman L., Eilam R., Weinberger A., Lotan-Pompan M., Lotem M., Levin Y., Lawley T. D., Adams D. J., Levesque M. P., Besser M. J., Schachter J., Golani O., Segal E., Ruppin E., Kvistborg P., Peterson S. N., Wargo J. A., Straussman R. & Samuels Y. (2021), Nature (London). 592, 7852, p. 138-143
  • CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma

    Authors: Lewinsky H., Gunes E. G., David K., Radomir L., Kramer M. P., Pellegrino B., Perpinial M., Chen J., He T. F., Mansour A. G., Teng K. Y., Bhattacharya S., Caserta E., Troadec E., Lee P., Feng M., Keats J., Krishnan A., Rosenzweig M., Yu J., Caligiuri M. A., Cohen Y., Shevetz O., Becker-Herman S., Pichiorri F., Rosen S. & Shachar I. (2021), JCI insight. 6, 4, 141683
  • Chromothripsis drives the evolution of gene amplification in cancer

    Authors: Shoshani O., Brunner S. F., Yaeger R., Ly P., Nechemia-Arbely Y., Kim D. H., Fang R., Castillon G. A., Yu M., Li J. S. Z., Sun Y., Ellisman M. H., Ren B., Campbell P. J. & Cleveland D. W. (2021), Nature. 591, 7848, p. 137-141
  • Persistent Inflammatory Stimulation Drives the Conversion of MSCs to Inflammatory CAFs That Promote Pro-Metastatic Characteristics in Breast Cancer Cells

    Authors: Rubinstein-Achiasaf L., Morein D., Ben-Yaakov H., Liubomirski Y., Meshel T., Elbaz E., Dorot O., Pichinuk E., Gershovits M., Weil M. & Ben-Baruch A. (2021), Cancers. 13, 6, 1472
  • Proteomic profiling of tissue exosomes indicates continuous release of malignant exosomes in urinary bladder cancer patients, even with pathologically undetectable tumour

    Authors: Eldh M., Mints M., Hiltbrunner S., Ladjevardi S., Alamdari F., Johansson M., Jakubczyk T., Veerman R. E., Winqvist O., Sherif A. & Gabrielsson S. (2021), Cancers. 13, 13, 3242
  • P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression

    Authors: Yeini E., Ofek P., Pozzi S., Albeck N., Ben-Shushan D., Tiram G., Golan S., Kleiner R., Sheinin R., Israeli Dangoor S., Reich-Zeliger S., Grossman R., Ram Z., Brem H., Hyde T. M., Magod P., Friedmann-Morvinski D., Madi A. & Satchi-Fainaro R. (2021), Nature Communications. 12, 1912
  • Isolation of a gene cluster from Armillaria gallica for the synthesis of armillyl orsellinatetype sesquiterpenoids

    Authors: Engels B., Heinig U., McElroy C., Meusinger R., Grothe T., Stadler M. & Jennewein S. (2021), Applied Microbiology and Biotechnology. 105, 1, p. 211-224
  • Relevance of Membrane Contact Sites in Cancer Progression

    Authors: Gil-Hernández A., Arroyo-Campuzano M., Simoni-Nieves A., Zazueta C., Gomez-Quiroz L. E. & Silva-Palacios A. (2021), Frontiers in Cell and Developmental Biology. 8, 622215
  • The glycine arginine-rich domain of the RNA-binding protein nucleolin regulates its subcellular localization

    Authors: Doron E., Koppel I., Abraham O., Rishal I., Smith T. P., Buchanan C. N., Sahoo P. K., Kadlec J., Oses-Prieto J. A., Kawaguchi R., Alber S., Zahavi E. E., Di Matteo P., Di Pizio A., Song D. A., Okladnikova N., Gordon D., Ben-Dor S., Haffner-Krausz R., Coppola G., Burlingame A. L., Jungwirth P., Twiss J. L. & Fainzilber M. (2021), EMBO Journal. 40, 20, e107158
  • The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development

    Authors: Sun X., Malandraki-Miller S., Kennedy T., Bassat E., Klaourakis K., Zhao J., Gamen E., Vieira J. M., Tzahor E. & Riley P. R. (2021), Development (Cambridge). 148, 9
  • CYP46A1-APOE axis at the choroid plexus is compromised in Alzheimer's disease but is amenable to rescue

    Authors: Tsitsou A., Suzzi S., Kenigsbuch M., Singer O., Strobelt R., Cahalon L., Arad M., Colaiuta S. P., Medina S., Kviatcovsky D. & Schwartz M. (2021),
  • The consumption of cholesterol-enriched diets conditions the development of a subtype of hcc with high aggressiveness and poor prognosis

    Authors: Simoni-Nieves A., Salas-Silva S., Chávez-Rodríguez L., Escobedo-Calvario A., Desoteux M., Bucio L., Souza V., Miranda-Labra R. U., Muñoz-Espinosa L. E., Coulouarn C., Gutiérrez-Ruiz M. C., Marquardt J. U. & Gomez-Quiroz L. E. (2021), Cancers. 13, 7, 1721
  • Molecular principles of recruitment and dynamics of guest proteins in liquid droplets

    Authors: Kamagata K., Iwaki N., Hazra M. K., Kanbayashi S., Banerjee T., Chiba R., Sakomoto S., Gaudon V., Castaing B., Takahashi H., Kimura M., Oikawa H., Takahashi S. & Levy Y. (2021), Scientific Reports. 11, 19323
  • Autophagy in major human diseases

    Authors: Klionsky D. J., Petroni G., Amaravadi R. K., Baehrecke E. H., Ballabio A., Boya P., Bravo-San Pedro J. M., Cadwell K., Cecconi F., Choi A. M., Choi M. E., Chu C. T., Codogno P., Colombo M., Cuervo A. M., Deretic V., Dikic I., Elazar Z., Eskelinen E. L., Fimia G. M., Gewirtz D. A., Green D. R., Hansen M., Jäättelä M., Johansen T., Juhász G., Karantza V., Kraft C., Kroemer G., Ktistakis N. T., Kumar S., Lopez-Otin C., Macleod K. F., Madeo F., Martinez J., Meléndez A., Mizushima N., Münz C., Penninger J. M., Perera R., Piacentini M., Reggiori F., Rubinsztein D. C., Ryan K., Sadoshima J., Santambrogio L., Scorrano L., Simon H. U., Simon A. K., Simonsen A., Stolz A., Tavernarakis N., Tooze S. A., Yoshimori T., Yuan J., Yue Z., Zhong Q., Galluzzi L. & Pietrocola F. (2021), EMBO Journal. 40, 19, e108863
  • The Key Role of Patient Involvement in the Development of Core Outcome Sets in Prostate Cancer

    Authors: Beyer K., MacLennan S. J., Moris L., Lardas M., Mastris K., Hooker G., Greene R., Briers E., Omar M. I., Healey J., Tripathee S., Gandaglia G., Venderbos L. D., Smith E. J., Bjorkqvist J., Asiimwe A., Huber J., Roobol M. J., Zong J. & Lancet D. (2021), European Urology Focus. 7, 5, p. 943-946
  • Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation

    Authors: McFarland A. P., Yalin A., Wang S., Cortez V. S., Landsberger T., Sudan R., Peng V., Miller H. L., Ricci B., David E., Faccio R., Amit I. & Colonna M. (2021), Immunity (Cambridge, Mass.). 54, 6, p. 1320-1337.e4
  • Alternative splicing of the inhibitory immune checkpoint receptor SLAMF6 generates a dominant positive form, boosting T-cell effector functions

    Authors: Hajaj E., Zisman E., Tzaban S., Merims S., Cohen J., Klein S., Frankenburg S., Sade-Feldman M., Tabach Y., Yizhak K., Navon A., Stepensky P., Hacohen N., Peretz T., Veillette A., Karni R., Eisenberg G. & Lotem M. (2021), Cancer Immunology Research. 9, 6, p. 637-650
  • Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles

    Authors: Tawil N., Bassawon R., Meehan B., Nehme A., Montermini L., Gayden T., De Jay N., Spinelli C., Chennakrishnaiah S., Choi D., Adnani L., Zeinieh M., Jabado N., Kleinman C. L., Witcher M., Riazalhosseini Y., Key N. S., Schiff D., Grover S. P., Mackman N., Couturier C. P., Petrecca K., Suvà M. L., Patel A., Tirosh I., Najafabadi H. & Rak J. (2021), Blood advances. 5, 6, p. 1682-1694
  • Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer

    Authors: Sjoberg H. T., Philippou Y., Magnussen A. L., Tullis I. D., Bridges E., Chatrian A., Lefebvre J., Tam K. H., Murphy E. A., Rittscher J., Preise D., Agemy L., Yechezkel T., Smart S. C., Kinchesh P., Gilchrist S., Allen D. P., Scheiblin D. A., Lockett S. J., Wink D. A., Lamb A. D., Mills I. G., Harris A., Muschel R. J., Vojnovic B., Scherz A., Hamdy F. C. & Bryant R. J. (2021), British Journal of Cancer. 125, 4, p. 534-546
  • BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators

    Authors: Castellanet O., Ahmad F., Vinik Y., Mills G. B., Habermann B., Borg J., Lev S., Lamballe F. & Maina F. (2021), Theranostics.. 11, 19, p. 9180-9197
  • The context-specific roles of urea cycle enzymes in tumorigenesis

    Authors: Hajaj E., Sciacovelli M., Frezza C. & Erez A. (2021), Molecular Cell. 81, 18, p. 3749-3759
  • Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

    Authors: Hara T., Chanoch-Myers R., Mathewson N. D., Myskiw C., Atta L., Bussema L., Eichhorn S. W., Greenwald A. C., Kinker G. S., Rodman C., Gonzalez Castro L. N., Wakimoto H., Rozenblatt-Rosen O., Zhuang X., Fan J., Hunter T., Verma I. M., Wucherpfennig K. W., Regev A., Suvà M. L. & Tirosh I. (2021), Cancer Cell. 39, 6, p. 779-792.e11
  • Diffusion is directional: Innovative diffusion tensor imaging to improve prostate cancer detection

    Authors: Shenhar C., Degani H., Ber Y., Baniel J., Tamir S., Benjaminov O., Rosen P., Furman-Haran E. & Margel D. (2021), Diagnostics. 11, 3, 563
  • Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies

    Authors: Borenstein-Katz A., Warszawski S., Amon R., Eilon M., Cohen-Dvashi H., Leviatan Ben-Arye S., Tasnima N., Yu H., Chen X., Padler-Karavani V., Fleishman S. J. & Diskin R. (2021), Journal of Molecular Biology. 433, 15, 167099
  • The relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents

    Authors: Mevorach T., Taler M., Dar S., Lebow M., Sapir I. S., Rotkopf R., Apter A., Fennig S., Chen A., Weizman A. & Amitai M. (2021), Scientific Reports. 11, 1, 11798
  • The prospects of tumor chemosensitivity testing at the single-cell level

    Authors: Yang C., Yang C., Yarden Y., To K. K. & Fu L. (2021), Drug Resistance Updates. 54, 100741
  • GDF11 restricts aberrant lipogenesis and changes in mitochondrial structure and function in human hepatocellular carcinoma cells

    Authors: Hernandez S., Simoni-Nieves A., Gerardo-Ramírez M., Torres S., Fucho R., Gonzalez J., Castellanos-Tapia L., Hernández-Pando R., Tejero-Barrera E., Bucio L., Souza V., Miranda-Labra R., Fernández-Checa J. C., Marquardt J. U., Gomez-Quiroz L. E., García-Ruiz C. & Gutiérrez-Ruiz M. C. (2021), Journal of Cellular Physiology. 236, 5, p. 4076-4090
  • Multiplexed imaging analysis of the tumor-immune microenvironment reveals predictors of outcome in triple-negative breast cancer

    Authors: Patwa A., Yamashita R., Long J., Angelo M., Yankielowicz-Keren L. & Rubin D. L. (2021), Communications Biology. 4, 1, 852
  • TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer

    Authors: Swain U., Friedlander G., Sehrawat U., Sarusi-Portuguez A., Rotkopf R., Ebert C., Paz-Elizur T., Dikstein R., Carell T., Geacintov N. E. & Livneh Z. (2021), International Journal of Molecular Sciences. 22, 13, 6957
  • Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models

    Authors: Marrocco I., Romaniello D., Vaknin I., DragoGarcia D., Oren R., Uribe M. L., Belugali Nataraj N., Ghosh S., Eilam R., Salame T., Lindzen M. & Yarden Y. (2021), EMBO Molecular Medicine. 13, 4, 13144
  • Anti-tumour immunity induces aberrant peptide presentation in melanoma

    Authors: Bartok O., Pataskar A., Nagel R., Laos M., Goldfarb E., Hayoun D., Levy R., Körner P., Kreuger I. Z. M., Champagne J., Zaal E. A., Bleijerveld O. B., Huang X., Kenski J., Wargo J., Brandis A., Levin Y., Mizrahi O., Alon M., Lebon S., Yang W., Nielsen M. M., Stern-Ginossar N., Altelaar M., Berkers C. R., Geiger T., Peeper D. S., Olweus J., Samuels Y. & Agami R. (2021), Nature. 590, 7845, p. 332-337
  • Efficient acquisition of tens of thousands of short tandem repeats in single-cell whole-genome-amplified DNA

    Authors: Tao L., Marx Z., Raz O. & Shapiro E. (2021), STAR Protocols. 2, 4, 100828
  • Coordinated regulation of WNT/β-catenin, c-Met, and integrin signalling pathways by miR-193b controls triple negative breast cancer metastatic traits

    Authors: Giacomelli C., Jung J., Wachter A., Ibing S., Will R., Uhlmann S., Mannsperger H., Sahin Ö., Yarden Y., Beißbarth T., Korf U., Körner C. & Wiemann S. (2021), BMC Cancer. 21, 1296
  • Clump sequencing exposes the spatial expression programs of intestinal secretory cells

    Authors: Manco R., Averbukh I., Porat Z., Bahar Halpern K., Amit I. & Itzkovitz S. (2021), Nature Communications. 12, p. -, 3074
  • β2 Integrin Signaling Cascade in Neutrophils: More Than a Single Function

    Authors: Bouti P., Webbers S. D., Fagerholm S. C., Alon R., Moser M., Matlung H. L. & Kuijpers T. W. (2021), Frontiers in Immunology. 11, 619925
  • Proteomic patterns associated with response to breast cancer neoadjuvant treatment

    Authors: Shenoy A., Belugali Nataraj N., Perry G., Loayza Puch F., Nagel R., Marin I., Balint N., Bossel N., Pavlovsky A., Barshack I., Kaufman B., Agami R., Yarden Y., Dadiani M. & Geiger T. (2021), Molecular Systems Biology. 16, 9, e9443
  • Reduced Lamin A/C Does Not Facilitate Cancer Cell Transendothelial Migration but Compromises Lung Metastasis

    Authors: Roncato F., Regev O., Feigelson S. W., Yadav S. K., Kaczmarczyk L., Levi N., Drago-Garcia D., Ovadia S., Kizner M., Addadi Y., Sabino J. C., Ovadya Y., de Almeida S. F., Feldmesser E., Gerlitz G. & Alon R. (2021), Cancers. 13, 10, 2383
  • CircRNAs: role in human diseases and potential use as biomarkers

    Authors: Verduci L., Tarcitano E., Strano S., Yarden Y. & Blandino G. (2021), Cell Death & Disease. 12, 468
  • Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response

    Authors: Ariav Y., Chng J. H., Christofk H. R., Ron-Harel N. & Erez A. (2021), Science advances. 7, 21, eabg6165
  • Immunotherapy for Triple-Negative Breast Cancer

    Authors: Cao Y., Chen C., Tao Y., Lin W. & Wang P. (2021), Pharmaceutics. 13, 12, 2003
  • Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis

    Authors: Bolik J., Krause F., Stevanovic M., Gandraß M., Thomsen I., Schacht S., Rieser E., Müller M., Schumacher N., Fritsch J., Wichert R., Galun E., Bergmann J., Röder C., Schafmayer C., Egberts J., Becker-Pauly C., Saftig P., Lucius R., Schneider-Brachert W., Barikbin R., Adam D., Voss M., Hitzl W., Krüger A., Strilic B., Sagi I., Walczak H., Rose-John S. & Schmidt-Arras D. (2021), Journal of Experimental Medicine. 219, 1, e20201039
  • Principles of signaling pathway modulation for enhancing human naive pluripotency induction

    Authors: Bayerl J., Ayyash M., Shani T., Manor Y. S., Gafni O., Massarwa R., Kalma Y., Aguilera-Castrejon A., Zerbib M., Amir H., Sheban D., Geula S., Mor N., Weinberger L., Naveh Tassa S., Krupalnik V., Oldak B., Livnat N., Tarazi S., Wildschutz E., Tawil S., Ashouokhi S., Lasman L., Rotter V., Hanna S., Ben-Yosef D., Novershtern N., Viukov S. & Hanna J. H. (2021), Cell Stem Cell. 28, 9, p. 1549-1565.e12
  • Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity

    Authors: Shani O., Raz Y., Monteran L., Scharff Y., Levi-Galibov O., Megides O., Shacham H., Cohen N., Silverbush D., Avivi C., Sharan R., Madi A., Scherz-Shouval R., Barshack I., Tsarfaty I. & Erez N. (2021), eLife. 10, e60745
  • Circadian Misalignment and Metabolic Disorders: A Story of Twisted Clocks

    Authors: Woller A. & Gonze D. (2021), Biology (Basel, Switzerland). 10, 3, 207
  • The key roles of cancer stem cell-derived extracellular vesicles

    Authors: Su C., Zhang J., Yarden Y. & Fu L. (2021), Signal Transduction and Targeted Therapy. 6, 1, 109
  • TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion

    Authors: You Y., Stelzl P., Joseph D. N., Aldo P. B., Maxwell A. J., Dekel N., Liao A., Whirledge S. & Mor G. (2021), Frontiers in Immunology. 12, 737401
  • EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired Resistance

    Authors: Uribe M. L., Marrocco I. & Yarden Y. (2021), Cancers. 13, 11, 2748
  • Conformation-specific inhibitory anti-mmp-7 monoclonal antibody sensitizes pancreatic ductal adenocarcinoma cells to chemotherapeutic cell kill

    Authors: Mohan V., Gaffney J. P., Solomonov I., Levin M., Klepfish M., Akbareian S., Grünwald B., Dym O., Eisenstein M., Yu K. H., Kelsen D. P., Krüger A., Edwards D. R. & Sagi I. (2021), Cancers. 13, 7, 1679
  • Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

    Authors: Dubiella C., Pinch B. J., Koikawa K., Zaidman D., Poon E., Manz T. D., Nabet B., He S., Resnick E., Rogel A., Langer E. M., Daniel C. J., Seo H., Chen Y., Adelmant G., Sharifzadeh S., Ficarro S. B., Martins da Costa B., Jamin Y., Zimmerman M. W., Lian X., Kibe S., Kozono S., Doctor Z. M., Browne C. M., Yang A., Stoler-Barak L., Shah R. B., Vangos N. E., Geffken E. A., Oren R., Koide E., Sidi S., Shulman Z., Wang C., Marto J. A., Dhe-Paganon S., Look T., Zhou X. Z., Lu K. P., Sears R. C., Chesler L., Gray N. S. & London N. (2021), Nature Chemical Biology. 17, 9, p. 954-963
  • Clinical Proteomics of Metastatic Melanoma Reveals Profiles of Organ Specificity and Treatment Resistance

    Authors: Beck L., Harel M., Yu S., Markovits E., Boursi B., Markel G. & Geiger T. (2021), Clinical Cancer Research. 27, 7, p. 2074-2086
  • Male predominance in AML is associated with specific preleukemic mutations

    Authors: De-Morgan A., Meggendorfer M., Haferlach C. & Shlush L. (2021),
  • Biological and therapeutic implications of a unique subtype of NPM1 mutated AML

    Authors: Mer A. S., Heath E. M., Madani Tonekaboni S. A., Dogan-Artun N., Nair S. K., Murison A., Garcia-Prat L., Shlush L., Hurren R., Voisin V., Bader G. D., Nislow C., Rantalainen M., Lehmann S., Gower M., Guidos C. J., Lupien M., Dick J. E., Minden M. D., Schimmer A. D. & Haibe-Kains B. (2021), Nature Communications. 12, 1, 1054
  • A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion

    Authors: Gonçalves C. A., Larsen M., Jung S., Stratmann J., Nakamura A., Leuschner M., Hersemann L., Keshara R., Perlman S., Lundvall L., Thuesen L. L., Hare K. J., Amit I., Jørgensen A., Kim Y. H., del Sol A. & Grapin-Botton A. (2021), Nature Communications. 12, 1, 3144
  • Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood

    Authors: Skead K., Houle A. A., Abelson S., Agbessi M., Bruat V., Lin B., Soave D., Shlush L., Wright S., Dick J., Morris Q. & Awadalla P. (2021), Nature Communications. 12, 1, 4921
  • Roles for growth factors and mutations in metastatic dissemination

    Authors: Nataraj N. B., Marrocco I. & Yarden Y. (2021), Biochemical Society Transactions. 49, 3, p. 1409-1423, BST2021004
  • A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma

    Authors: Choi J. E., Sebastian C., Ferrer C. M., Lewis C. A., Sade-Feldman M., LaSalle T., Gonye A., Lopez B. G., Abdelmoula W. M., Regan M. S., Cetinbas M., Pascual G., Wojtkiewicz G. R., Silveira G. G., Boon R., Ross K. N., Tirosh I., Saladi S. V., Ellisen L. W., Sadreyev R. I., Benitah S. A., Agar N. Y., Hacohen N. & Mostoslavsky R. (2021), Nature metabolism. 3, 2, p. 182-195
  • Single cell biologya Keystone Symposia report

    Authors: Cable J., Elowitz M. B., Domingos A. I., Habib N., Itzkovitz S., Hamidzada H., Balzer M. S., Yanai I., Liberali P., Whited J., Streets A., Cai L., Stergachis A. B., Hong C. K. Y., Keren L., Guilliams M., Alon U., Shalek A. K., Hamel R., Pfau S. J., Raj A., Quake S. R., Zhang N. R., Fan J., Trapnell C., Wang B., Greenwald N. F., Vento-Tormo R., Santos S. D., Spencer S. L., Garcia H. G., Arekatla G., Gaiti F., Arbel-Goren R., Rulands S., Junker J. P., Klein A. M., Morris S. A., Murray J. I., Galloway K. E., Ratz M. & Romeike M. (2021), Annals of the New York Academy of Sciences. 1506, 1, p. 74-97
  • Using a recently approved tumor mutational burden biomarker to stratify patients for immunotherapy may introduce a sex bias

    Authors: Sinha N., Sinha S., Cheng K., Madan S., Erez A., Ryan B. M., Schäffer A. A., Aldape K. & Ruppin E. (2021),
  • Metabolic decisions in development and diseasea Keystone Symposia report

    Authors: Cable J., Pourquié O., Wellen K. E., Finley L. W., Aulehla A., Gould A. P., Teleman A., Tu W. B., Garrett W. S., Miguel-Aliaga I., Perrimon N., Hooper L. V., Walhout A. J., Wei W., Alexandrov T., Erez A., Ralser M., Rabinowitz J. D., Hemalatha A., Gutiérrez-Pérez P., Chandel N. S., Rutter J., Locasale J. W., Landoni J. C. & Christofk H. (2021), Annals of the New York Academy of Sciences. 1506, 1, p. 55-73
  • The evolution of leukaemia from preleukaemic and leukaemic stem cells

    Authors: Shlush L. I. & Feldman T. (2021), Journal of Internal Medicine.
  • Tumour inflammation signature and expression of S100A12 and HLA class I improve survival in HPV-negative hypopharyngeal cancer

    Authors: Mints M., Landin D., Näsman A., Mirzaie L., Ursu R. G., Zupancic M., Marklund L., Dalianis T., Munck-Wikland E. & Ramqvist T. (2021), Scientific Reports. 11, 1, 1782
  • Reciprocal REGγ-mTORC1 regulation promotes glycolytic metabolism in hepatocellular carcinoma

    Authors: Yao L., Xuan Y., Zhang H., Yang B., Ma X., Wang T., Meng T., Sun W., Wei H., Ma X., Moses R., Xiao J., Zhang P., Ge C., Li J., Li L., Li X., Li J. & Zhang B. (2021), Oncogene. 40, 3, p. 677-692
  • Avidity optimization of a MAGE-A1-specific TCR with somatic hypermutation

    Authors: Bassan D., Gozlan Y. M., Sharbi-Yunger A., Tzehoval E., Greenstein E., Bitan L., Friedman N. & Eisenbach L. (2021), European Journal of Immunology. 51, 6, p. 1505-1518
  • MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression

    Authors: Kinker G. S., Ostrowski L. H., Ribeiro P. A., Chanoch R., Muxel S. M., Tirosh I., Spadoni G., Rivara S., Martins V. R., Santos T. G., Markus R. P. & Fernandes P. A. (2021), Journal of Molecular Medicine. 2, p. 289-301
  • Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis

    Authors: Beyaz S., Chung C., Mou H., Bauer-Rowe K. E., Xifaras M. E., Ergin I., Dohnalova L., Biton M., Shekhar K., Eskiocak O., Papciak K., Ozler K., Almeqdadi M., Yueh B., Fein M., Annamalai D., Valle-Encinas E., Erdemir A., Dogum K., Shah V., Alici-Garipcan A., Meyer H. V., Özata D. M., Elinav E., Kucukural A., Kumar P., McAleer J. P., Fox J. G., Thaiss C. A., Regev A., Roper J., Orkin S. H. & Yilmaz Ö. H. (2021), Cell Stem Cell. 28, 11, p. 1922-1935.e5
  • NASH limits anti-tumour surveillance in immunotherapy-treated HCC

    Authors: Pfister D., Núñez N. G., Pinyol R., Govaere O., Pinter M., Szydlowska M., Gupta R., Qiu M., Deczkowska A., Weiner A., Müller F., Sinha A., Friebel E., Engleitner T., Lenggenhager D., Moncsek A., Heide D., Stirm K., Kosla J., Kotsiliti E., Leone V., Dudek M., Yousuf S., Inverso D., Singh I., Teijeiro A., Castet F., Montironi C., Haber P. K., Tiniakos D., Bedossa P., Cockell S., Younes R., Vacca M., Marra F., Schattenberg J. M., Allison M., Bugianesi E., Ratziu V., Pressiani T., DAlessio A., Personeni N., Rimassa L., Daly A. K., Scheiner B., Pomej K., Kirstein M. M., Vogel A., Peck-Radosavljevic M., Hucke F., Finkelmeier F., Waidmann O., Trojan J., Schulze K., Wege H., Koch S., Weinmann A., Bueter M., Rössler F., Siebenhüner A., De Dosso S., Mallm J. P., Umansky V., Jugold M., Luedde T., Schietinger A., Schirmacher P., Emu B., Augustin H. G., Billeter A., Müller-Stich B., Kikuchi H., Duda D. G., Kütting F., Waldschmidt D. T., Ebert M. P., Rahbari N., Mei H. E., Schulz A. R., Ringelhan M., Malek N., Spahn S., Bitzer M., Ruiz de Galarreta M., Lujambio A., Dufour J. F., Marron T. U., Kaseb A., Kudo M., Huang Y. H., Djouder N., Wolter K., Zender L., Marche P. N., Decaens T., Pinato D. J., Rad R., Mertens J. C., Weber A., Unger K., Meissner F., Roth S., Jilkova Z. M., Claassen M., Anstee Q. M., Amit I., Knolle P., Becher B., Llovet J. M. & Heikenwalder M. (2021), Nature (London). 592, 7854, p. 450-456
  • Leptin modulates gene expression in the heart, cardiomyocytes and the adipose tissue thus mitigating LPS-induced damage

    Authors: Abd Alkhaleq H., Kornowski R., Waldman M., Zemel R., Lev D. L., Shainberg A., Miskin R. & Hochhauser E. (2021), Experimental Cell Research. 404, 2, 112647
  • Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma

    Authors: Peri A., Greenstein E., Alon M., Pai J. A., Dingjan T., Reich-Zeliger S., Barnea E., Barbolin C., Levy R., Arnedo-Pac C., Kalaora S., Dassa B., Feldmesser E., Shang P., Greenberg P., Levin Y., Benedek G., Levesque M. P., Adams D. J., Lotem M., Wilmott J. S., Scolyer R. A., Jönsson G. B., Admon A., Rosenberg S. A., Cohen C. J., Niv M. Y., Lopez-Bigas N., Satpathy A. T., Friedman N. & Samuels Y. (2021), Journal of Clinical Investigation. 131, 20, e129466
  • Cancer-associated fibroblasts promote aggressive gastric cancer phenotypes via heat shock factor 1-mediated secretion of extracellular vesicles

    Authors: Grunberg N., Pevsner-Fischer M., Goshen-Lago T., Diment J., Stein Y., Lavon H., Mayer S., Levi-Galibov O., Friedman G., Ofir-Birin Y., Syu L., Migliore C., Shimoni E., Stemmer S. M., Brenner B., Dlugosz A. A., Lyden D., Regev-Rudzki N., Ben-Aharon I. & Scherz-Shouval R. (2021), Cancer Research. 81, 7, p. 1639-1653
  • ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation

    Authors: Brandao R., Kwa M. Q., Yarden Y. & Brakebusch C. (2021), FEBS Open Bio. 11, 6, p. 1579-1592
  • Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells

    Authors: Shorer Arbel Y., Katz B., Gabizon R., Shraga A., Bronstein Y., Kamdjou T., Globerson Levin A., Perry C., Avivi I., London N. & Herishanu Y. (2021), Frontiers in Oncology. 11, 646971
  • Positron Emission Tomography/Computed Tomography with Gallium-68labeled Prostate-specific Membrane Antigen Detects Relapse After Vascular-targeted Photodynamic Therapy in a Prostate Cancer Model

    Authors: Alvim R., Nagar K., Das S., Lebdai S., Wong N., Somma A., Hughes C., Thomas J., Monette S., Scherz A., Kim K., Grimm J. & Coleman J. A. (2021), European Urology Focus. 7, 2, p. 472-478
  • R_Enhancement of Biological Activities of Copper(II) Complexes Containing Guanidine Derivatives by Enrofloxacin

    Authors: Meenongwa A., Brissos R. F., Soikum C., Chaveerach P., Trongpanich Y. & Chaveerach U. (2021), Journal of Molecular Structure. 1241, 130645
  • Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes

    Authors: Sano T., Kageyama T., Fang V., Kedmi R., Martinez C. S., Talbot J., Chen A., Cabrera I., Gorshko O., Kurakake R., Yang Y., Ng C., Schwab S. R. & Littman D. R. (2021), Cell Reports. 36, 8, 109608
  • The evolutionarily conserved long non-coding RNA LINC00261 drives neuroendocrine prostate cancer proliferation and metastasis via distinct nuclear and cytoplasmic mechanisms

    Authors: Mather R. L., Parolia A., Carson S. E., Venalainen E., Roig-Carles D., Jaber M., Chu S., Alborelli I., Wu R., Lin D., Nabavi N., Jachetti E., Colombo M. P., Xue H., Pucci P., Ci X., Hawkes C., Li Y., Pandha H., Ulitsky I., Marconett C., Quagliata L., Jiang W., Romero I., Wang Y. & Crea F. (2021), Molecular Oncology. 15, 7, p. 1921-1941
  • Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma

    Authors: Jansky S., Sharma A. K., Körber V., Quintero A., Toprak U. H., Wecht E. M., Gartlgruber M., Greco A., Chomsky E., Grünewald T. G. P., Henrich K., Tanay A., Herrmann C., Höfer T. & Westermann F. (2021), Nature Genetics.
  • Astrocytes Downregulate Inflammation in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome: Applicability to COVID-19

    Authors: Izrael M., Molakandov K., Revel A., Slutsky S. G., Sonnenfeld T., Weiss J. M. & Revel M. (2021), Frontiers in Medicine. 8, 740071
  • Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans

    Authors: Levi-Ferber M., Shalash R., Le-Thomas A., Salzberg Y., Shurgi M., Benichou J. I., Ashkenazi A. & Henis-Korenblit S. (2021), eLife. e65644
  • Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing

    Authors: Zada M., Wang S., Bornstein C., David E., Moshe A., Li B., Shlomi-loubaton S., Gatt M. E., Gur C., Lavi N., Ganzel C., Luttwak E., Chubar E., Rouvio O., Vaxman I., Pasvolsky O., Ballan M., Tadmor T., Nemets A., Jarchowcky-dolberg O., Shvetz O., Laiba M., Shpilberg O., Dally N., Avivi I., Weiner A. & Amit I. (2021), Nature Medicine. 27, 3, p. 491-503
  • Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors

    Authors: Marcu A., Schlosser A., Keupp A., Trautwein N., Johann P., Wölfl M., Lager J., Monoranu C. M., Walz J. S., Henkel L. M., Krauß J., Ebinger M., Schuhmann M., Thomale U. W., Pietsch T., Klinker E., Schlegel P. G., Oyen F., Reisner Y., Rammensee H. G. & Eyrich M. (2021), Journal for ImmunoTherapy of Cancer. 9, 10, e003404
  • XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

    Authors: Deczkowska A., David E., Ramadori P., Pfister D., Safran M., At The B., Giladi A., Jaitin D. A., Barboy O., Cohen M., Yofe I., Gur C., Shlomi-Loubaton S., Henri S., Suhail Y., Qiu M., Kam S., Hermon H., Lahat E., Ben Yakov G., Cohen-Ezra O., Davidov Y., Likhter M., Goitein D., Roth S., Weber A., Malissen B., Weiner A., Ben-Ari Z., Heikenwälder M., Elinav E. & Amit I. (2021), Nature Medicine. 27, 6, p. 1043-1054
  • Albumin-Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells

    Authors: Cooper I., Schnaider-Beeri M., Fridkin M. & Shechter Y. (2021), Pharmaceutics. 14, 1, 71
  • Combined ox40 agonist and pd-1 inhibitor immunotherapy improves the efficacy of vascular targeted photodynamic therapy in a urothelial tumor model

    Authors: Alvim R. G., Georgala P., Nogueira L., Somma A. J., Nagar K., Thomas J., Alvim L., Riegel A., Hughes C., Chen J., Reis A. B., Lebdai S., Scherz A., Zanganeh S., Gardner R., Kim K. & Coleman J. A. (2021), Molecules. 26, 12, 3744
  • Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis

    Authors: Tyler M. & Tirosh I. (2021), Nature Communications. 12, 1, 2592
  • Treatment results from a phase I study of WST11 phototherapy (VTP) for upper tract urothelial carcinoma

    Authors: Nogueira L., Tracey A., Alvim R. G., Reisz P., Sjoberg D. D., Demac Q., Benfante N., Nagar K., Thomas J., Cheng J., Kim K., Solit D. B., Scherz A. J. & Coleman J. (2021), Journal of Clinical Oncology. 39, 6_suppl, p. 460-460
  • The collagenmodifying enzyme plod2 is induced and required during l1mediated colon cancer progression

    Authors: Cheriyamundath S., Kumar A., Gavert N., Brabletz T. & Ben-Zeev A. (2021), International Journal of Molecular Sciences. 22, 7, 3552
  • Senescent cells and the incidence of age-related diseases

    Authors: Katzir I., Adler M., Karin O., Mendelsohn-Cohen N., Mayo A. & Alon U. (2021), Aging Cell. 20, 3, e13314
  • Accelerating AXL targeting for TNBC therapy

  • The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC

    Authors: Khera L., Vinik Y., Maina F. & Lev S. (2021), Life Science Alliance. 4, 6, e202000985
  • Putative Blood Somatic Mutations in Post-Traumatic Stress Disorder-Symptomatic Soldiers: High Impact of Cytoskeletal and Inflammatory Proteins

    Authors: Sragovich S., Gershovits M., Lam J. C., Li V. O. & Gozes I. (2021), Journal of Alzheimer's Disease. 79, 4, p. 1723-1734
  • Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

    Authors: Koikawa K., Kibe S., Suizu F., Sekino N., Kim N., Manz T. D., Pinch B. J., Akshinthala D., Verma A., Gaglia G., Nezu Y., Ke S., Qiu C., Ohuchida K., Oda Y., Lee T. H., Wegiel B., Clohessy J. G., London N., Santagata S., Wulf G. M., Hidalgo M., Muthuswamy S. K., Nakamura M., Gray N. S., Zhou X. Z. & Lu K. P. (2021), Cell. 184, 18, p. 4753-4771.e27
  • IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy

    Authors: Jacob Berger A., Gigi E., Kupershmidt L., Meir Z., Gavert N., Zwang Y., Prior A., Gilad S., Harush U., Haviv I., Stemmer S. M., Blum G., Merquiol E., Mardamshina M., Kaminski Strauss S., Friedlander G., Bar J., Kamer I., Reizel Y., Geiger T., Pilpel Y., Levin Y., Tanay A., Barzel B., Reuveni H. & Straussman R. (2021), Nature Cancer. 2, 10, p. 1055-1070
  • Host-Dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors

    Authors: Haga Y., Marrocco I., Noronha A., Uribe M. L., Nataraj N. B., Sekar A., Drago-Garcia D., Borgoni S., Lindzen M., Giri S., Wiemann S., Tsutsumi Y. & Yarden Y. (2021), Cancer Research. 81, 14, p. 3862-3875
  • Neoadjuvant vascular-targeted photodynamic therapy improves survival and reduces recurrence and progression in a mouse model of urothelial cancer

    Authors: Rosenzweig B., Corradi R. B., Budhu S., Alvim R., Recabal P., La Rosa S., Somma A., Monette S., Scherz A., Kim K. & Coleman J. A. (2021), Scientific Reports. 11, 1, 4842
  • Transient genomic instability drives tumorigenesis through accelerated clonal evolution

    Authors: Shoshani O., Bakker B., de Haan L., Tijhuis A., Wang Y., Kim D. H., Maldonado M., Demarest M., Artates J., Zhengyu O., Mark A., Wardenaar R., Sasik R., Spierings D., Vitre B., Fisch K., Foijer F. & Cleveland D. W. (2021), Genes and Development. 35, 15-16, p. 1093-1109
  • Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining

    Authors: Feldman T., Bercovich A., Moskovitz Y., Chapal-Ilani N., Mitchell A., Medeiros J. J. F., Biezuner T., Kaushansky N., Minden M. D., Gupta V., Milyavsky M., Livneh Z., Tanay A. & Shlush L. I. (2021), Nature Communications. 12, 1, 2455
  • Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior

    Authors: Parikh R., Sorek E., Parikh S., Michael K., Bikovski L., Tshori S., Shefer G., Mingelgreen S., Zornitzki T., Knobler H., Chodick G., Mardamshina M., Boonman A., Kronfeld-Schor N., Bar-Joseph H., Ben-Yosef D., Amir H., Pavlovsky M., Matz H., Ben-Dov T., Golan T., Nizri E., Liber D., Liel Y., Brenner R., Gepner Y., Karnieli-Miller O., Hemi R., Shalgi R., Kimchi T., Percik R., Weller A. & Levy C. (2021), Cell reports (Cambridge). 36, 8, 109579
  • Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review

    Authors: Kenner B., Chari S. T., Kelsen D., Klimstra D. S., Pandol S. J., Rosenthal M., Rustgi A. K., Taylor J. A., Yala A., Abul-Husn N., Andersen D. K., Bernstein D., Brunak S., Canto M. I., Eldar Y. C., Fishman E. K., Fleshman J., Go V. L. W., Holt J. M., Field B., Goldberg A., Hoos W., Iacobuzio-Donahue C., Li D., Lidgard G., Maitra A., Matrisian L. M., Poblete S., Rothschild L., Sander C., Schwartz L. H., Shalit U., Srivastava S. & Wolpin B. (2021), Pancreas. 50, 3, p. 251-279
  • Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies

    Authors: Cohen M., Giladi A., Raposo C., Zada M., Li B., Ruckh J., Deczkowska A., Mohar B., Shechter R., Lichtenstein R. G., Amit I. & Schwartz M. (2021), Life Science Alliance. 4, 1, 202000907
  • Therapeutic efficacy of 225Ac-PSMA-617 targeted alpha therapy in patients of metastatic castrate resistant prostate cancer after taxane-based chemotherapy

    Authors: Sen I., Thakral P., Tiwari P., Pant V., Das S. S., Manda D. & Raina V. (2021), Annals of Nuclear Medicine. 35, 7, p. 794-810
  • Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation

    Authors: Canu V., Donzelli S., Sacconi A., Lo Sardo F., Pulito C., Bossel N., Di Benedetto A., Muti P., Botti C., Domany E., Bicciato S., Strano S., Yarden Y. & Blandino G. (2021), Cell Death and Differentiation. 28, 5, p. 1493-1511
  • VEGFC/FLT4-induced cell-cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells

    Authors: Jerafi-Vider A., Bassi I., Moshe N., Tevet Y., Hen G., Splittstoesser D., Shin M., Lawson N. D. & Yaniv K. (2021), Cell Reports. 35, 11, 109255
  • Proteogenomics of glioblastoma associates molecular patterns with survival

    Authors: Yanovich-Arad G., Ofek P., Yeini E., Mardamshina M., Danilevsky A., Shomron N., Grossman R., Satchi-Fainaro R. & Geiger T. (2021), Cell reports (Cambridge). 34, 9, 108787
  • DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

    Authors: Batra R. N., Lifshitz A., Vidakovic A. T., Chin S., Sati-Batra A., Sammut S., Provenzano E., Ali H. R., Dariush A., Bruna A., Murphy L., Purushotham A., Ellis I., Green A., Garrett-Bakelman F. E., Mason C., Melnick A., Aparicio S. A. J. R., Rueda O. M., Caldas C. & Tanay A. (2021), Nature Communications. 12, 1, 5406
  • Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones

    Authors: Rayo J., Gregor R., Jacob N. T., Dandela R., Dubinsky L., Yashkin A., Aranovich A., Thangaraj M., Ernst O., Barash E., Malitsky S., Florea B. I., Krom B. P., Wiemer E. A. C., Kickhoefer V. A., Rome L. H., Mathison J. C., Kaufmann G. F., Overkleeft H. S., Cravatt B. F., Zor T., Janda K. D., Ulevitch R. J., Kravchenko V. V. & Meijler M. M. (2021), Proceedings of the National Academy of Sciences - PNAS. 118, 12, e201252911
  • SelfComplementary Zwitterionic Peptides Direct Nanoparticle Assembly and Enable Enzymatic Selection of Endocytic Pathways

    Authors: Huang R. H., Nayeem N., He Y., Morales J., Graham D., Klajn R., Contel M., O'Brien S. & Ulijn R. V. (2021), Advanced materials (Weinheim). 34, 1, e2104962
  • Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anti-cancer activities in lung adenocarcinoma

    Authors: Singh A., Erijman A., Noronha A., Kumar H., Peleg Y., Yarden Y. & Shifman J. M. (2021), Journal of Biological Chemistry. 297, 6, 101353
  • Microbiome and cancer

    Authors: Cullin N., Azevedo Antunes C., Straussman R., Stein-Thoeringer C. K. & Elinav E. (2021), Cancer Cell. 39, 10, p. 1317-1341
  • Tumor heterogeneity

    Authors: Pe'er D., Ogawa S., Elhanani O., Keren L., Oliver T. G. & Wedge D. (2021), Cancer Cell. 39, 8, p. 1015-1017
  • Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ)

    Authors: Degtjarik O., Golovenko D., Diskin-Posner Y., Abrahmsén L., Rozenberg H. & Shakked Z. (2021), Nature Communications. 12, 7057
  • MEK inhibition reverses aberrant signaling in melanoma cells through reorganization of nras and braf in self nanoclusters

    Authors: Yakovian O., Sajman J., Arafeh R., Neve-Oz Y., Alon M., Samuels Y. & Sherman E. (2021), Cancer research (Chicago, Ill.). 81, 5, p. 1279-1292
  • Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts

    Authors: Quinn J. J., Jones M. G., Okimoto R. A., Nanjo S., Chan M. M., Yosef N., Bivona T. G. & Weissman J. S. (2021), Science. 371, 6532, abc1944
  • Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells

    Authors: Roncato F., Regev O., Yadav S. K. & Alon R. (2021), Cell Adhesion and Migration. 15, 1, p. 166-179
  • Beyond cells: The extracellular circulating 20S proteasomes

    Authors: Dwivedi V., Yaniv K. & Sharon M. (2021), Biochimica et Biophysica Acta - Molecular Basis of Disease. 1867, 3, 166041
  • P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas

    Authors: Rousso-Noori L., Mastandrea I., Talmor S., Waks T., Globerson Levin A., Haugas M., Teesalu T., Alvarez-Vallina L., Eshhar Z. & Friedmann-Morvinski D. (2021), Nature Communications. 12, 1, 3615
  • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

    Authors: Mathewson N. D., Ashenberg O., Tirosh I., Gritsch S., Perez E. M., Marx S., Jerby-Arnon L., Chanoch-Myers R., Hara T., Richman A. R., Ito Y., Pyrdol J., Friedrich M., Schumann K., Poitras M. J., Gokhale P. C., Gonzalez Castro L. N., Shore M. E., Hebert C. M., Shaw B., Cahill H. L., Drummond M., Zhang W., Olawoyin O., Wakimoto H., Rozenblatt-Rosen O., Brastianos P. K., Liu X. S., Jones P. S., Cahill D. P., Frosch M. P., Louis D. N., Freeman G. J., Ligon K. L., Marson A., Chiocca E. A., Reardon D. A., Regev A., Suvà M. L. & Wucherpfennig K. W. (2021), Cell. 184, 5, p. 1281-1298
  • SCIRT lncRNA Restrains Tumorigenesis by Opposing Transcriptional Programs of Tumor-Initiating Cells

    Authors: Zagorac S., de Giorgio A., Dabrowska A., Kalisz M., Casas-Vila N., Cathcart P., Yiu A., Ottaviani S., Degani N., Lombardo Y., Tweedie A., Nissan T., Vance K. W., Ulitsky I., Stebbing J. & Castellano L. (2021), Cancer Research. 81, 3, p. 580-593
  • Tumor cells in light-chain amyloidosis and myeloma show distinct transcriptional rewiring of normal plasma cell development

    Authors: Alameda D., Goicoechea I., Vicari M., Arriazu E., Nevone A., Rodríguez S., Lasa M., Puig N., Cedena M., Alignani D., Garate S., Lara-Astiaso D., Vilas-Zornoza A., Sarvide S., Ocio E. M., Lecumberri R., Garcia de Coca A., Labrador J., Gonzalez M., Palomera L., Gironella M., Cabañas V., Casanova M., Oriol A., Krsnik I., Pérez-Montaña A., de la Rubia J., de la Puerta J., de Arriba F., Fazio V. M., Martinez-Lopez J., Lahuerta J., Mateos M., Odero M. D., Prosper F., Weiner A., Amit I., Nuvolone M., San-Miguel J. F. F. & Paiva B. (2021), Blood. 138, 17, p. 1583-1589
  • Hemopressin as a breakthrough for the cannabinoid field

    Authors: Heimann A. S., Dale C. S., Guimarães F. S., Reis R. A., Navon A., Shmuelov M. A., Rioli V., Gomes I., Devi L. L. & Ferro E. S. (2021), Neuropharmacology. 183, 108406
  • β2-Integrin Adhesion Regulates Dendritic Cell Epigenetic and Transcriptional Landscapes to Restrict Dendritic Cell Maturation and Tumor Rejection

    Authors: Guenther C., Faisal I., Fusciello M., Sokolova M., Harjunpää H., Ilander M., Tallberg R., Vartiainen M. K., Alon R., Gonzalez-Granado J., Cerullo V. & Fagerholm S. C. (2021), Cancer Immunology Research. 9, 11, p. 1354-1369
  • PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR

    Authors: Ghosh S., Nataraj N. B., Noronha A., Patkar S., Sekar A., Mukherjee S., Winograd-Katz S., Kramarski L., Verma A., Lindzen M., Garcia D. D., Green J., Eisenberg G., Gil-Henn H., Basu A., Lender Y., Weiss S., Oren M., Lotem M., Geiger B., Ruppin E. & Yarden Y. (2021), Cell Reports. 35, 8, 109181
  • TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis

    Authors: Uribe M. L., Dahlhoff M., Batra R. N., Nataraj N. B., Haga Y., Drago-Garcia D., Marrocco I., Sekar A., Ghosh S., Vaknin I., Lebon S., Kramarski L., Tsutsumi Y., Choi I., Rueda O. M., Caldas C. & Yarden Y. (2021), Science Signaling. 14, 688, eabe6156
  • Mechanism of cholangiocellular damage and repair during cholestasis

    Authors: Salas-Silva S., Simoni-Nieves A., Chávez-Rodríguez L., Gutiérrez-Ruiz M. C., Bucio L. & Quiroz L. E. (2021), Annals of Hepatology. 26, 100530
  • Intratumoral heterogeneity in cancer progression and response to immunotherapy

    Authors: Vitale I., Shema E., Loi S. & Galluzzi L. (2021), Nature Medicine. 27, 2, p. 212-224
  • Retrospective cell lineage reconstruction in humans by using short tandem repeats

    Authors: Tao L., Raz O., Marx Z., Ghosh M. S., Huber S., Greindl-Junghans J., Biezuner T., Amir S., Milo L., Adar R., Levy R., Onn A., Chapal-Ilani N., Berman V., Ben Arie A., Rom G., Oron B., Halaban R., Czyz Z. T., Werner-Klein M., Klein C. A. & Shapiro E. (2021), Cell Reports Methods. 1, 3, 100054
  • Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53

    Authors: Lindzen M., Ghosh S., Noronha A., Drago D., Nataraj N. B., Leitner O., Carvalho S., Zmora E., Sapoznik S., Shany K. B., Levanon K., Aderka D., Ramírez B. S., Dahlhoff M., McNeish I. & Yarden Y. (2021), Oncogene. 40, 21, p. 3665-3679
  • Cell Senescence, DNA Damage, and Metabolism

    Authors: Shmulevich R. & Krizhanovsky V. (2021), Antioxidants & Redox Signaling. 34, 4, p. 324-334
  • Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

    Authors: Spencer C. N., McQuade J. L., Gopalakrishnan V., McCulloch J. A., Vetizou M., Cogdill A. P., Khan M. A. W., Zhang X., White M. G., Peterson C. B., Wong M. C., Morad G., Rodgers T., Badger J. H., Helmink B. A., Andrews M. C., Rodrigues R. R., Morgun A., Kim Y. S., Roszik J., Hoffman K. L., Zheng J., Zhou Y., Medik Y. B., Kahn L. M., Johnson S., Hudgens C. W., Wani K., Gaudreau P., Harris A. L., Jamal M. A., Baruch E. N., Perez-Guijarro E., Day C., Merlino G., Pazdrak B., Lochmann B. S., Szczepaniak-Sloane R. A., Arora R., Anderson J., Zobniw C. M., Posada E., Sirmans E., Simon J., Haydu L. E., Burton E. M., Wang L., Dang M., Clise-Dwyer K., Schneider S., Chapman T., Anang N. A. S., Duncan S., Toker J., Malke J. C., Glitza I. C., Amaria R. N., Tawbi H. A., Diab A., Wong M. K., Patel S. P., Woodman S. E., Davies M. A., Ross M. I., Gershenwald J. E., Lee J. E., Hwu P., Jensen V., Samuels Y., Straussman R., Ajami N. J., Nelson K. C., Nezi L., Petrosino J. F., Futreal P. A., Lazar A. J., Hu J., Jenq R. R., Tetzlaff M. T., Yan Y., Garrett W. S., Huttenhower C., Sharma P., Watowich S. S., Allison J. P., Cohen L., Trinchieri G., Daniel C. R. & Wargo J. A. (2021), Science. 374, 6575, p. 1632-1640
  • Systematic detection of m6A-modified transcripts at single-molecule and single-cell resolution

    Authors: Kim K. L., van Galen P., Hovestadt V., Rahme G. J., Andreishcheva E. N., Shinde A., Gaskell E., Jones D. R., Shema E. & Bernstein B. E. (2021), Cell Reports Methods. 1, 5, 100061
  • Deuterium MRSI characterizations of glucose metabolism in orthotopic pancreatic cancer mouse models

    Authors: Markovic S., Roussel T., Agemy L., Sasson K., Preise D., Scherz A. & Frydman L. (2021), NMR in Biomedicine. e4569
  • Gatekeepers of the gut: The roles of proteasomes at the gastrointestinal barrier

    Authors: Mohapatra G., Eisenberg-Lerner A. & Merbl Y. (2021), Biomolecules. 11, 7, 989
  • alpha-Actinin-4 drives invasiveness by regulating myosin IIB expression and myosin IIA localization

    Authors: Barai A., Mukherjee A., Das A., Saxena N. & Sen S. (2021), Journal of Cell Science. 134, 23, jcs258581
  • Proteomic analysis of necroptotic extracellular vesicles

    Authors: Shlomovitz I., Erlich Z., Arad G., Edry-Botzer L., Zargarian S., Cohen H., Manko T., Ofir-Birin Y., Cooks T., Regev-Rudzki N. & Gerlic M. (2021), Cell Death and Disease. 12, 11, 1059
  • Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression

    Authors: Barnabas G. D., Lee J. S., Shami T., Harel M., Beck L., Selitrennik M., Jerby-Arnon L., Erez N., Ruppin E. & Geiger T. (2021), Cancer research (Chicago, Ill.). 81, 6, p. 1443-1456
  • Bimodal magnetic resonance and optical imaging of extracellular matrix remodelling by orthotopic ovarian tumours

    Authors: Bochner F., Fellus-Alyagor L., Ketter D., Golani O., Biton I. & Neeman M. (2020), British Journal of Cancer. 2, p. 216-225
  • Effect of ibrutinib on the ifn response of chronic lymphocytic leukemia cells

    Authors: Xia M., Luo T. Y., Shi Y., Wang G., Tsui H., Harari D. & Spaner D. E. (2020), The Journal of immunology (1950). 205, 10, p. 2629-2639
  • Stromal Expression of the Core Clock Gene Period 2 Is Essential for Tumor Initiation and Metastatic Colonization

    Authors: Shaashua L., Mayer S., Lior C., Lavon H., Novoselsky A. & Scherz-Shouval R. (2020), Frontiers in Cell and Developmental Biology. 8, 587697
  • Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation

    Authors: Wu Y., Chou T., Young L., Hsieh F., Pan H., Mo S., Brown S. B., Chen R., Kimchi A. & Lai M. (2020), Cell Death & Disease. 11, 5, 305
  • The microbiome and cytosolic innate immune receptors

    Authors: Liwinski T., Zheng D. & Elinav E. (2020), Immunological Reviews. 1, p. 207-224
  • Myotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma

    Authors: Weidner P., Soehn M., Schroeder T., Helm L., Hauber V., Gutting T., Betge J., Roecken C., Rohrbacher F. N., Pattabiraman V. R., Bode J. W., Seger R., Saar D., Nunes-Alves A., Wade R. C., Ebert M. P. A. & Burgermeister E. (2020), Oncogenesis. 9, 6, 59
  • The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

    Authors: Deczkowska A., Weiner A. & Amit I. (2020), Cell. 181, 6, p. 1207-1217
  • Regulation of eIF2α by RNF4 Promotes Melanoma Tumorigenesis and Therapy Resistance

    Authors: Avitan-Hersh E., Feng Y., Oknin Vaisman A., Abu Ahmad Y., Zohar Y., Zhang T., Lee J. S., Lazar I., Sheikh Khalil S., Feiler Y., Kluger H., Kahana C., Brown K., Ruppin E., Ronai Z. A. & Orian A. (2020), Journal of Investigative Dermatology. 12, p. 2466-2477
  • Modeling Multiplexed Images with Spatial-LDA Reveals Novel Tissue Microenvironments

    Authors: Chen Z., Soifer I., Hilton H., Keren L. & Jojic V. (2020), Journal of Computational Biology. 8, p. 1204-1218
  • Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma

    Authors: Kalaora S., Lee J. S., Barnea E., Levy R., Greenberg P., Alon M., Yagel G., Bar Eli G., Oren R., Peri A., Patkar S., Bitton L., Rosenberg S. A., Lotem M., Levin Y., Admon A., Ruppin E. & Samuels Y. (2020), Nature Communications. 11, 1, 896
  • Are noncommunicable diseases communicable?

    Authors: Finlay B. B., Blaser M. J., Bosch T. C. G., Dominguez -Bello M. C. & Elinav E. (2020),
  • Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

    Authors: Kinker G. S., Greenwald A. C., Tal R., Orlova Z., Cuoco M. S., McFarland J. M., Warren A., Rodman C., Roth J. A., Bender S. A., Kumar B., Rocco J. W., Fernandes P. A., Mader C. C., Keren-Shaul H., Plotnikov A., Barr H., Tsherniak A., Rozenblatt-Rosen O., Krizhanovsky V., Puram S. V., Regev A. & Tirosh I. (2020), Nature Genetics. 52, 11, p. 1208-1218
  • Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation

    Authors: Schwartz M., Portugez A. S., Attia B. Z., Tannenbaum M., Cohen L., Loza O., Chase E., Turman Y., Kaplan T., Salah Z. & Hakim O. (2020), Communications Biology. 3, 1, 696
  • A single cell atlas of the human liver tumor microenvironment

    Authors: Massalha H., Bahar Halpern K., Abu-Gazala S., Jana T., Massasa E. E., Moor A. E., Buchauer L., Rozenberg M., Pikarsky E., Amit I., Zamir G. & Itzkovitz S. (2020), Molecular Systems Biology. 16, 12, e9682
  • Induction and characterization of pancreatic cancer in a transgenic pig model

    Authors: Edward Boas F., Nurili F., Bendet A., Cheleuitte-Nieves C., Basturk O., Askan G., Michel A. O., Monette S., Ziv E., Sofocleous C. T., Maxwell A. W., Schook L. B., Solomon S. B., Kelsen D. P., Scherz A. & Yarmohammadi H. (2020), PLoS ONE. 15, 9, e0239391
  • Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor-Thr(701) phosphorylation

    Authors: Gaviraghi M., Rabellino A., Andolfo A., Brand M., Brombin C., Bagnato P., De Feudis G., Raimondi A., Locatelli A., Tosoni D., Mazza D., Gianni L., Tonon G., Yarden Y., Tacchetti C. & Daniele T. (2020), Scientific Reports. 10, 1, 16906
  • Mutant p53 oncogenicity: dominant-negative or gain-of-function?

    Authors: Stein Y., Aloni-Grinstein R. & Rotter V. (2020), Carcinogenesis. 41, 12, p. 1635-1647
  • Developments in Vascular-Targeted Photodynamic Therapy for Urologic Malignancies

    Authors: Nogueira L., Tracey A. T., Alvim R., Reisz P., Scherz A., Coleman J. A. & Kim K. (2020), Molecules (Basel, Switzerland). 25, 22, 5417
  • The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma

    Authors: Gamaev L., Mizrahi L., Friehmann T., Rosenberg N., Pappo O., Olam D., Zeira E., Bahar Halpern, K., Caruso S., Zucman-Rossi J., Axelrod J. H., Galun E. & Goldenberg D. S. (2020), Oncogene. 40, 1, p. 127-139
  • Predicting and affecting response to cancer therapy based on pathway-level biomarkers

    Authors: Ben-Hamo R., Berger A. J., Gavert N., Miller M., Pines G., Oren R., Pikarsky E., Benes C. H., Neuman T., Zwang Y., Efroni S., Getz G. & Straussman R. (2020), Nature Communications. 11, 1, 3296
  • Genome-wide association study identifies 16 genomic regions associated with circulating cytokines at birth

    Authors: Wang Y., Nudel R., Benros M. E., Skogstrand K., Fishilevich S. & Lancet D. (2020), PLoS Genetics. 16, 11, e1009163
  • Targeting HER3, a Catalytically Defective Receptor Tyrosine Kinase, Prevents Resistance of Lung Cancer to a Third-Generation EGFR Kinase Inhibitor

    Authors: Romaniello D., Marrocco I., Nataraj N. B., Ferrer I., Drago-Garcia D., Vaknin I., Oren R., Lindzen M., Ghosh S., Kreitman M., Kittel J. C., Gaborit N., Baez G. B., Sanchez B., Eilam R., Pikarsky E., Paz-Ares L. & Yarden Y. (2020), Cancers. 12, 9, p. 1-20, 2394
  • A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma

    Authors: Nagler A., Vredevoogd D. W., Alon M., Cheng P. F., Trabish S., Kalaora S., Arafeh R., Goldin V., Levesque M. P., Peeper D. S. & Samuels Y. (2020), Pigment Cell and Melanoma Research. 33, 2, p. 334-344
  • Interleukin 10 Restores Lipopolysaccharide-Induced Alterations in Synaptic Plasticity Probed by Repetitive Magnetic Stimulation

    Authors: Lenz M., Eichler A., Kruse P., Strehl A., Rodriguez-Rozada S., Goren I., Yogev N., Frank S., Waisman A., Deller T., Jung S., Maggio N. & Vlachos A. (2020), Frontiers in Immunology. 11, 614509
  • Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death

    Authors: Park S., Park H., Park S., Hong S. M., Yoon S., Morgan M. J. & Kim Y. (2020), Cell Death & Disease. 11, 9, 744
  • Mitochondrial carrier homolog 2 is necessary for AML survival

    Authors: Khan D. H., Mullokandov M., Wu Y., Voisin V., Gronda M. V., Hurren R., Wang X., MacLean N., Jeyaraju D. V., Jitkova Y., Xu G. W., Laister R. C., Seneviratne A., Blatman Z., Ketala T., Bader G. D., Marhon S. A., Carvalho D. D. D., Minden M. D., Gross A. & Schimmer A. D. (2020), Blood. 136, 1, p. 81-92
  • A framework for advancing our understanding of cancer-associated fibroblasts

    Authors: Sahai E., Astsaturov I., Cukierman E., DeNardo D. G., Egeblad M., Evans R. M., Fearon D., Greten F. R., Hingorani S. R., Hunter T., Hynes R. O., Jain R. K., Janowitz T., Jorgensen C., Kimmelman A. C., Kolonin M. G., Maki R. G., Powers R. S., Pure E., Ramirez D. C., Scherz-Shouval R., Sherman M. H., Stewart S., Tlsty T. D., Tuveson D. A., Watt F. M., Weaver V., Weeraratna A. T. & Werb Z. (2020), Nature Reviews Cancer. 20, 3, p. 174-186
  • A single-cell landscape of high-grade serous ovarian cancer

    Authors: Izar B., Tirosh I., Stover E. H., Wakiro I., Cuoco M. S., Alter I., Rodman C., Leeson R., Su M., Shah P., Iwanicki M., Walker S. R., Kanodia A., Melms J. C., Mei S., Lin J., Porter C. B. M., Slyper M., Waldman J., Jerby-Arnon L., Ashenberg O., Brinker T. J., Mills C., Rogava M., Vigneau S., Sorger P. K., Garraway L. A., Konstantinopoulos P. A., Liu J. F., Matulonis U., Johnson B. E., Rozenblatt-Rosen O., Rotem A. & Regev A. (2020), Nature Medicine. 26, 8, p. 1271-1279
  • Interleukin-9 regulates macrophage activation in the progressive multiple sclerosis brain

    Authors: Donninelli G., Saraf-Sinik I., Mazziotti V., Capone A., Grasso M. G., Battistini L., Reynolds R., Magliozzi R. & Volpe E. (2020), Journal of Neuroinflammation. 17, 1, 149
  • Rational design of universal immunotherapy for TfR1-tropic arenaviruses

    Authors: Cohen-Dvashi H., Amon R., Agans K. N., Cross R. W., Borenstein-Katz A., Mateo M., Baize S., Padler-Karavani V., Geisbert T. W. & Diskin R. (2020), Nature Communications. 11, 1, 67
  • Immune related proteins and tumor infiltrating CD8+lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (HPV) and clinical outcome

    Authors: Landin D., Ahrlund-Richter A., Mirzaie L., Mints M., Nasman A., Kolev A., Marklund L., Dalianis T., Munck-Wikland E. & Ramqvist T. (2020), Head and Neck. 42, 11, p. 3206-3217
  • Pleiotropic tumor suppressor functions of WWOX antagonize metastasis

    Authors: Khawaled S., Nigita G., Distefano R., Oster S., Suh S., Smith Y., Khalaileh A., Peng Y., Croce C. M., Geiger T., Seewaldt V. L. & Aqeilan R. I. (2020), Signal Transduction and Targeted Therapy. 5, 1, 43
  • NF-κB-miR-155 axis activation mediates ovulation-induced oncogenic effects in fallopian tube epithelium

    Authors: Brand H., Barnabas G. D., Sapoznik S., Bahar-Shany K., Pozniak Y., Yung Y., Hourvitz A., Geiger T., Jacob-Hirsch J. & Levanon K. (2020), Carcinogenesis (New York). 41, 12, p. 1703-1712
  • Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts

    Authors: Kim K., Hu W., Audenet F., Almassi N., Hanrahan A. J., Murray K., Bagrodia A., Wong N., Clinton T. N., Dason S., Mohan V., Jebiwott S., Nagar K., Gao J., Penson A., Hughes C., Gordon B., Chen Z., Dong Y., Watson P. A., Alvim R., Elzein A., Gao S. P., Cocco E., Santin A. D., Ostrovnaya I., Hsieh J. J., Sagi I., Pietzak E. J., Hakimi A. A., Rosenberg J. E., Iyer G., Vargas H. A., Scaltriti M., Al-Ahmadie H., Solit D. B. & Coleman J. A. (2020), Nature Communications. 11, 1, 1975
  • Optimal multiparametric set-up modelled for best survival outcomes in palliative treatment of liver malignancies: unsupervised machine learning and 3 PM recommendations

    Authors: Goldstein E., Yeghiazaryan K., Ahmad A., Giordano F. A., Froehlich H. & Golubnitschaja O. (2020), EPMA Journal. 11, 3, p. 505-515
  • Single-cell analysis of clonal maintenance of transcriptional and epigenetic states in cancer cells

    Authors: Meir Z., Mukamel Z., Chomsky E., Lifshitz A. & Tanay A. (2020), Nature Genetics. 52, 7, p. 709-718
  • Immunomodulatory Properties of Leishmania Extracellular Vesicles During Host-Parasite Interaction: Differential Activation of TLRs and NF-kappa B Translocation by Dermotropic and Viscerotropic Species

    Authors: Nogueira P. M., de Menezes-Neto A., Borges V. M., Descoteaux A., Torrecilhas A. C., Xander P., Revach O., Regev-Rudzki N. & Soares R. P. (2020), Frontiers in Cellular and Infection Microbiology. 10, 380
  • The Glioma Stem Cell Model in the Era of Single-Cell Genomics

    Authors: Suva M. L. & Tirosh I. (2020), Cancer Cell. 37, 5, p. 630-636
  • Inter-Tumor Heterogeneity-Melanomas Respond Differently to GM-CSF-Mediated Activation

    Authors: Moshe A., Izraely S., Sagi-Assif O., Malka S., Ben-Menachem S., Meshel T., Pasmanik-Chor M., Hoon D. S. & Witz I. P. (2020), Cells. 9, 7, 1683
  • Microbiome genomics for cancer prediction

    Authors: Adlung L., Elinav E., Greten T. F. & Korangy F. (2020), Nature Cancer. 1, 4, p. 379-381
  • Breast Cancer-Derived Microparticles Reduce Cancer Cell Adhesion, an Effect Augmented by Chemotherapy

    Authors: Shechter D., Harel M., Mukherjee A., Sagredo L. M., Loven D., Prinz E., Avraham S., Orian-Rousseau V., Geiger T., Shaked Y. & Wolfenson H. (2020), Cells (Basel, Switzerland). 9, 10, 2263
  • Time-resolved profiling reveals ATF3 as a novel mediator of endocrine resistance in breast cancer

    Authors: Borgoni S., Sofyalı E., Soleimani M., Wilhelm H., Müller-Decker K., Will R., Noronha A., Beumers L., Verschure P. J., Yarden Y., Magnani L., van Kampen A. H., Moerland P. D. & Wiemann S. (2020), Cancers. 12, 10, p. 1-19, 2918
  • CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

    Authors: Rosenblum D., Gutkin A., Kedmi R., Ramishetti S., Veiga N., Jacobi A. M., Schubert M. S., Friedmann-Morvinski D., Cohen Z. R., Behlke M. A., Lieberman J. & Peer D. (2020), Science advances. 6, 47, eabc9450
  • Pharmacological LRH-1/Nr5a2 inhibition limits pro-inflammatory cytokine production in macrophages and associated experimental hepatitis

    Authors: Schwaderer J., Phan T. S., Glöckner A., Delp J., Leist M., Brunner T. & Delgado M. E. (2020), Cell Death and Disease. 11, 2, 154
  • Effect of IV Administration of a Gadolinium-Based Contrast Agent on Breast Diffusion-Tensor Imaging

    Authors: Scaranelo A. M., Degani H., Grobgeld D., Talbot N., Bodolai K. & Furman-Haran E. (2020), American Journal of Roentgenology. 215, 4, p. 1030-1036
  • Nanobodies Targeting Prostate-specific Membrane Antigen for the Imaging and Therapy of Prostate Cancer

    Authors: Rosenfeld L., Sananes A., Zur Y., Cohen S., Dhara K., Gelkop S., Ben Zeev E., Shahar A., Lobel L., Akabayov B., Arbely E. & Papo N. (2020), Journal of Medicinal Chemistry. 63, 14, p. 7601-7615
  • Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models

    Authors: Feldman T., Grossman-Haham I., Elkis Y., Vilela P., Moskovits N., Barshack I., Salame T. M., Fass D. & Ilani T. (2020), Oncotarget. 11, 4, p. 386-398
  • Emerging roles of ECM remodeling processes in cancer

    Authors: Mohan V., Das A. & Sagi I. (2020), Seminars in Cancer Biology. 62, p. 192-200
  • Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody

    Authors: Cohen L., Sagi I., Bigelman E., Solomonov I., Aloshin A., Ben-Shoshan J., Rozenbaum Z., Keren G. & Entin-Meer M. (2020), PLoS ONE. 15, 4, e0231202
  • Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer's Disease Immunotherapy

    Authors: Castellani G. & Schwartz M. (2020), Trends in Immunology. 41, 9, p. 794-804
  • A Unified Linear Viscoelastic Model of the Cell Nucleus Defines the Mechanical Contributions of Lamins and Chromatin

    Authors: Wintner O., Hirsch-Attas N., Schlossberg M., Brofman F., Friedman R., Kupervaser M., Kitsberg D. & Buxboim A. (2020), Advanced Science. 7, 8, 1901222
  • The human tumor microbiome is composed of tumor type-specific intracellular bacteria

    Authors: Nejman D., Livyatan I., Fuks G., Gavert N., Zwang Y., Geller L. T., Rotter-Maskowitz A., Weiser R., Mallel G., Gigi E., Meltser A., Douglas G. M., Kamer I., Gopalakrishnan V., Dadosh T., Levin-Zaidman S., Avnet S., Atlan T., Cooper Z. A., Arora R., Cogdill A. P., Khan M. A. W., Ologun G., Bussi Y., Weinberger A., Lotan-Pompan M., Golani O., Perry G., Rokah M., Bahar-Shany K., Rozeman E. A., Blank C. U., Ronai A., Shaoul R., Amit A., Dorfman T., Kremer R., Cohen Z. R., Harnof S., Siegal T., Yehuda-Shnaidman E., Gal-Yam E. N., Shapira H., Baldini N., Langille M. G. I., Ben-Nun A., Kaufman B., Nissan A., Golan T., Dadiani M., Levanon K., Bar J., Yust-Katz S., Barshack I., Peeper D. S., Raz D. J., Segal E., Wargo J. A., Sandbank J., Shental N. & Straussman R. (2020), Science. 368, 6494, p. 973-980
  • Cu(II)-Metallacryptands Self-Assembled to Vesicular Aggregates Capable of Encapsulating and Transporting an Anticancer Drug Inside Cancer Cells

    Authors: Biswas P., Sarkar K. & Dastidar P. (2020), Macromolecular Bioscience. 20, 6, 2000044
  • The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy

    Authors: Wang X., Wang F., Zhong M., Yarden Y. & Fu L. (2020), Molecular Cancer. 19, 1, 81
  • Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge

    Authors: Shemer A., Scheyltjens I., Frumer G. R., Kim J., Grozovski J., Ayanaw S., Dassa B., Van Hove H., Chappell-Maor L., Boura-Halfon S., Leshkowitz D., Mueller W., Maggio N., Movahedi K. & Jung S. (2020), Immunity. 53, 5, p. 1033-1049.e7
  • IL-16 processing in sentinel node regulatory T cells is a factor in bladder cancer immunity

    Authors: Krantz D., Mints M., Winerdal M., Riklund K., Rutishauser D., Zubarev R., Zirakhzadeh A. A., Alamdari F., Johansson M., Sherif A. & Winqvist O. (2020), Scandinavian Journal of Immunology. 92, 6, e12926
  • Rational Design and Synthesis of Methyl-β-d-galactomalonyl Phenyl Esters as Potent Galectin-8N Antagonists

    Authors: Patel B., Kishor C., Houston T. A., Shatz-Azoulay H., Zick Y., Vinik Y. & Blanchard H. (2020), Journal of Medicinal Chemistry. 63, 20, p. 11573-11584
  • Diffusion-weighted breast MRI of malignancies with submillimeter resolution and immunity to artifacts by spatiotemporal encoding at 3T

    Authors: Solomon E., Liberman G., Nissan N., Furman-Haran E., Sklair-Levy M. & Frydman L. (2020), Magnetic Resonance in Medicine. 84, 3, p. 1391-1403
  • Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma

    Authors: Parikh A., Shin J. H., Faquin W., Lin D. T., Tirosh I., Sunwoo J. B. & Puram S. V. (2020), Journal for ImmunoTherapy of Cancer. 8, 2, 001048
  • Role of m(6)A in Embryonic Stem Cell Differentiation and in Gametogenesis

    Authors: Lasman L., Hanna J. H. & Novershtern N. (2020), Epigenomes. 4, 1, 5
  • Increased circulatory IL-6 during 8-week fluoxetine treatment is a risk factor for suicidal behaviors in youth

    Authors: Amitai M., Taler M., Ben-Baruch R., Lebow M., Rotkopf R., Apter A., Fennig S., Weizman A. & Chen A. (2020), Brain Behavior And Immunity. 87, p. 301-308
  • Wnt/β-catenin target genes in colon cancer metastasis: The special case of l1cam

    Authors: Cheriyamundath S. & Ben-Zeev A. (2020), Cancers. 12, 11, 3444
  • The ECM path of senescence in aging: components and modifiers

    Authors: Levi N., Papismadov N., Solomonov I., Sagi I. & Krizhanovsky V. (2020), The FEBS journal. 287, 13, p. 2636-2646
  • The mitochondrial carrier Citrin plays a role in regulating cellular energy during carcinogenesis

    Authors: Rabinovich S., Silberman A., Adler L., Agron S., Levin-Zaidman S., Bahat A., Porat Z., Ben-Zeev E., Geva I., Itkin M., Malitsky S., Buchaklian A., Helbling D., Dimmock D. & Erez A. (2020), Oncogene. 39, 1, p. 164-175
  • Paying the price for standing tall: Fluid mechanics of prostate pathology

    Authors: Gat Y., Joshua S., Vuk-Pavlovic S. & Goren M. (2020), Prostate. 80, 15, p. 1297-1303
  • Diffusivity in breast malignancies analyzed for b>1000s/mm 2 at 1mm inplane resolutions: Insight from Gaussian and nonGaussian behaviors

    Authors: Otikovs M., Nissan N., FurmanHaran E., Anaby D., Allweis T. M., Agassi R., SklairLevy M. & Frydman L. (2020), Journal of Magnetic Resonance Imaging.
  • LifeTime and improving European healthcare through cell-based interceptive medicine

    Authors: Rajewsky N., Almouzni G., Amit I., Tanay A. & Reiner O. (2020), Nature. 587, 7834, p. 377-386
  • Single-cell genomic approaches for developing the next generation of immunotherapies

    Authors: Yofe I., Dahan R. & Amit I. (2020), Nature Medicine. 26, 2, p. 171-177
  • Lipid Transfer Proteins and Membrane Contact Sites in Human Cancer

    Authors: Peretti D., Kim S., Tufi R. & Lev S. (2020), Frontiers in Cell and Developmental Biology. 7, 371
  • Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease

    Authors: Vardi A., Ben-Dor S., Cho S. M., Kalinke U., Spanier J. & Futerman A. H. (2020), Journal of Neuroinflammation. 17, 265
  • Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature

    Authors: Tavor S., Shalit T., Chapal Ilani N., Moskovitz Y., Livnat N., Groner Y., Barr H., Minden M. D., Plotnikov A., Deininger M. W., Kaushansky N. & Shlush L. I. (2020), Haematologica. 105, 12, p. 2795-2804
  • Bystander IFN-gamma activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

    Authors: Thibaut R., Bost P., Milo I., Cazaux M., Lemaitre F., Garcia Z., Amit I., Breart B., Cornuot C., Schwikowski B. & Bousso P. (2020), Nature Cancer. 1, 3, p. 302-314
  • Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

    Authors: Mathew N. R., Vinnakota J. M., Apostolova P., Erny D., Hamarsheh S., Andrieux G., Kim J., Hanke K., Goldmann T., Chappell-Maor L., El-Khawanky N., Ihorst G., Schmidt D., Duyster J., Finke J., Blank T., Boerries M., Blazar B. R., Jung S., Prinz M. & Zeiser R. (2020), The Journal of Clinical Investigation. 130, 3, p. 1315-1329
  • A 20-Year Journey from Axonal Injury to Neurodegenerative Diseases and the Prospect of Immunotherapy for Combating Alzheimer's Disease

    Authors: Schwartz M., Ramos J. M. P. & Ben-Yehuda H. (2020), Journal of Immunology. 204, 2, p. 243-250
  • Intravital imaging of vascular anomalies and extracellular matrix remodeling in orthotopic pancreatic tumors

    Authors: Bochner F., Mohan V., Zinger A., Golani O., Schroeder A., Sagi I. & Neeman M. (2020), International Journal of Cancer. 146, 8, p. 2209-2217
  • High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies

    Authors: Haedicke K., Agemy L., Omar M., Berezhnoi A., Roberts S., Longo-Machado C., Skubal M., Nagar K., Hsu H., Kim K., Reiner T., Coleman J., Ntziachristos V., Scherz A. & Grimm J. (2020), Nature Biomedical Engineering. 4, 3, p. 286-297
  • A Division of Labor between YAP and TAZ in Non-Small Cell Lung Cancer

    Authors: Shreberk-Shaked M., Dassa B., Sinha S., Di Agostino S., Azuri I., Mukherjee S., Aylon Y., Blandino G., Ruppin E. & Oren M. (2020), Cancer Research. 80, 19, p. 4145-4157
  • An increase in IL-6 levels at 6-month follow-up visit is associated with SSRI-emergent suicidality in high-risk children and adolescents treated with fluoxetine

    Authors: Amitai M., Taler M., Lebow M., Ben-Baruch R., Apter A., Fennig S., Weizman A. & Chen A. (2020), European Neuropsychopharmacology. 40, p. 61-69
  • High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function

    Authors: Grosheva I., Zheng D., Levy M., Polansky O., Lichtenstein A., Golani O., Dori-Bachash M., Moresi C., Shapiro H., Del Mare-Roumani S., Valdes-Mas R., He Y., Karbi H., Chen M., Harmelin A., Straussman R., Yissachar N., Elinav E. & Geiger B. (2020), Gastroenterology. 159, 5, p. 1807-1823
  • Identification of a potent and selective covalent Pin1 inhibitor

    Authors: Pinch B. J., Doctor Z. M., Nabet B., Browne C. M., Seo H., Mohardt M. L., Kozono S., Lian X., Manz T. D., Chun Y., Kibe S., Zaidman D., Daitchman D., Yeoh Z. C., Vangos N. E., Geffken E. A., Tan L., Ficarro S. B., London N., Marto J. A., Buratowski S., Dhe-Paganon S., Zhou X. Z., Lu K. P. & Gray N. S. (2020), Nature Chemical Biology. 16, 9, p. 979-987
  • Directed evolution of therapeutic antibodies targeting glycosylation in cancer

    Authors: Amon R., Rosenfeld R., Perlmutter S., Grant O. C., Yehuda S., Borenstein-Katz A., Alcalay R., Marshanski T., Yu H., Diskin R., Woods R. J., Chen X. & Padler-Karavani V. (2020), Cancers. 12, 10, 2824
  • DNA Repair Biomarker for Lung Cancer Risk and its Correlation With Airway Cells Gene Expression

    Authors: Paz-Elizur T., Leitner-Dagan Y., Meyer K. B., Markus B., Giorgi F. M., O'Reilly M., Kim H., Evgy Y., Fluss R., Freedman L. S., Rintoul R. C., Ponder B. & Livneh Z. (2020), Jnci cancer spectrum. 4, 1, pkz067
  • The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

    Authors: Kadosh E., Snir-Alkalay I., Venkatachalam A., May S., Lasry A., Elyada E., Zinger A., Shaham M., Vaalani G., Mernberger M., Stiewe T., Pikarsky E., Oren M. & Ben-Neriah Y. (2020), Nature. 7827, p. 133-+
  • Introducing PIONEER: a project to harness big data in prostate cancer research

    Authors: Omar M. I., Roobol M. J., Ribal M. J., Abbott T. & Lancet D. (2020), Nature Reviews Urology. 17, 6, p. 351-361
  • Generation of human endothelium in pig embryos deficient in ETV2

    Authors: Das S., Koyano-Nakagawa N., Gafni O., Maeng G., Singh B. N., Rasmussen T., Pan X., Choi K., Mickelson D., Gong W., Pota P., Weaver C. V., Kren S., Hanna J. H., Yannopoulos D., Garry M. G. & Garry D. J. (2020), Nature Biotechnology. 38, 3, p. 297-302
  • The potential anti-inflammatory and anti-nociceptive effects of rat hemopressin (PVNFKFLSH) in experimental arthritis

    Authors: Camargo L. L., Denadai-Souza A., Yshii L. M., Lima C., Teixeira S. A., Cerqueira A. R., Gewehr M. C., Fernandes E. S., Schenka A. A., Muscará M. N., Ferro E. S. & Costa S. K. (2020), European Journal of Pharmacology. 173636
  • Nasopharyngeal carcinoma joins the single-cell party

    Authors: Mints M. & Tirosh I. (2020),
  • Trypanosoma cruzi-Infected Human Macrophages Shed Proinflammatory Extracellular Vesicles That Enhance Host-Cell Invasion via Toll-Like Receptor 2

    Authors: Cronemberger-Andrade A., Xander P., Soares R. P., Pessoa N. L., Campos M. A., Ellis C. C., Grajeda B., Ofir-Birin Y., Almeida I. C., Regev-Rudzki N. & Torrecilhas A. C. (2020), Frontiers in Cellular and Infection Microbiology. 10, 99
  • Characterization of the human tumor microbiome reveals tumor-type specific intra-cellular bacteria

    Authors: Livyatan I., Nejman D., Shental N. & Straussman R. (2020), OncoImmunology. 9, 1, 1800957
  • beta-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus

    Authors: Zhang M., Lai Y., Krupalnik V., Guo P., Guo X., Zhou J., Xu Y., Yu Z., Liu L., Jiang A., Li W., Ma G., Li N., Fu X., Lv Y., Jiang M., Tariq M., Kanwal S., Liu H., Xu X., Zhang H., Huang Y., Wang L., Chen S., Babarinde I. A., Luo Z., Wang D., Zhou T., Ward C., He M., Ibanez D. P., Li Y., Zhou J., Yuan J., Feng Y., Arumugam K., Di Vicino U., Bao X., Wu G., Schambach A., Wang H., Sun H., Gao F., Qin B., Hutchins A. P., Doble B. W., Hartmann C., Cosma M. P., Qin Y., Xu G., Chen R., Volpe G., Chen L., Hanna J. H. & Esteban M. A. (2020), Science Advances. 6, 29, 1593
  • Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53-associated features

    Authors: Benor G., Fuks G., Chin S., Rueda O. M., Mukherjee S., Arandkar S., Aylon Y., Caldas C., Domany E. & Oren M. (2020), Molecular Oncology. 14, 8, p. 1640-1652
  • Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

    Authors: Lamballe F., Ahmad F., Vinik Y., Castellanet O., Daian F., Muller A., Kohler U. A., Bailly A., Josselin E., Castellano R., Cayrou C., Charafe-Jauffret E., Mills G. B., Geli V., Borg J., Lev S. & Maina F. (2020), Advanced Science. 3, 2003049
  • Mapping cell phenotypes in breast cancer

    Authors: Keren L. & Angelo M. (2020), Nature Reviews Cancer. 1, 2, p. 156-157
  • Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells

    Authors: Levite M., Zelig D., Friedman A., Ilouz N., Eilam R., Bromberg Z., Lasu A. A. R., Arbel-Alon S., Edvardson S., Tarshish M., Riek L. P., Lako R. L., Reubinoff B., Lebendiker M., Yaish D., Stavsky A. & Galun E. (2020), Journal of Autoimmunity. 112, 102462
  • Proteasome-dependent degradation of Smad7 is critical for lung cancer metastasis

    Authors: Tong L., Shen S., Huang Q., Fu J., Wang T., Pan L., Zhang P., Chen G., Huang T., Li K., Liu Q., Xie S., Yang X., Moses R. E., Li X. & Li L. (2020), Cell Death and Differentiation. 27, 6, p. 1795-1806
  • Across the Globe: Proteogenomic Landscapes of Lung Cancer

    Authors: Yanovich-Arad G. & Geiger T. (2020),
  • Publisher Correction: Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome (BMC Biology, (2020), 18, 1, (163), 10.1186/s12915-020-00893-2)

    Authors: Shaashua L., Eckerling A., Israeli B., Yanovich G., Rosenne E., Fichman-Horn S., Zvi I. B., Sorski L., Haldar R., Satchi-Fainaro R., Geiger T., Sloan E. K. & Ben-Eliyahu S. (2020),
  • Metabolic alterations in the tumor microenvironment and their role in oncogenesis

    Authors: Eisenberg L., Eisenberg-Bord M., Eisenberg-Lerner A. & Sagi-Eisenberg R. (2020), Cancer Letters. 484, p. 65-71
  • Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma

    Authors: Mur E. B., Bernardo S., Papon L., Mancini M., Fabbrizio E., Goussard M., Ferrer I., Giry A., Quantin X., Pujol J., Calvayrac O., Moll H. P., Glasson Y., Pirot N., Turtoi A., Canamero M., Wong K., Yarden Y., Casanova E., Soria J., Colinge J., Siebel C. W., Mazieres J., Favre G., Paz-Ares L. & Maraver A. (2020), Journal of Clinical Investigation. 130, 2, p. 612-624
  • Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

    Authors: Katzenelenbogen Y., Sheban F., Yalin A., Yofe I., Svetlichnyy D., Jaitin D. A., Bornstein C., Moshe A., Keren-Shaul H., Cohen M., Wang S., Li B., David E., Salame T., Weiner A. & Amit I. (2020), Cell. 182, 4, p. 872-885.e19
  • Targeting Metabolic Plasticity and flexibility Dynamics for Cancer Therapy

    Authors: Fendt S., Frezza C. & Erez A. (2020), Cancer Discovery. 10, 12, p. 1797-1807
  • Treatment of Multiple Myeloma Using Chimeric Antigen Receptor T Cells with Dual Specificity

    Authors: Levin A. G., Slobodkin M. R., Waks T., Horn G., Ninio-Many L., Unger N. D., Ohayon Y., Suliman S., Cohen Y., Tartakovsky B., Naparstek E., Avivi I. & Eshhar Z. (2020), Cancer Immunology Research. 8, 12, p. 1485-1495
  • NOP10 predicts lung cancer prognosis and its associated small nucleolar RNAs drive proliferation and migration

    Authors: Cui C., Liu Y., Gerloff D., Rohde C., Pauli C., Koehn M., Misiak D., Oellerich T., Schwartz S., Schmidt L., Wiewrodt R., Marra A., Hillejan L., Bartel F., Wickenhauser C., Huettelmaier S., Goellner S., Zhou F., Edemir B. & Mueller-Tidow C. (2020), Oncogene. 40, 5, p. 909-921
  • The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice

    Authors: Shatz-Azoulay H., Vinik Y., Isaac R., Kohler U., Lev S. & Zick Y. (2020), Scientific Reports. 10, 1, 7375
  • Deconstructing tumor heterogeneity: The stromal perspective

    Authors: Vickman R. E., Faget D. V., Beachy P., Beebe D., Bhowmick N. A., Cukierman E., Deng W., Granneman J. G., Hildesheim J., Kalluri R., Lau K. S., Lengyel E., Lundeberg J., Moscat J., Nelson P. S., Pietras K., Politi K., Puré E., Scherz-Shouval R., Sherman M. H., Tuveson D., Weeraratna A. T., White R. M., Wong M. H., Woodhouse E. C., Zheng Y., Hayward S. W. & Stewart S. A. (2020), Oncotarget. 11, 40, p. 3621-3632
  • Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome

    Authors: Shaashua L., Eckerling A., Israeli B., Yanovich G., Rosenne E., Fichman-Horn S., Ben Zvi I., Sorski L., Haldar R., Satchi-Fainaro R., Geiger T., Sloan E. K. & Ben-Eliyahu S. (2020), BMC Biology. 18, 1, 163
  • Identification of a truncated beta 1-chimaerin variant that inactivates nuclear Rac1

    Authors: Casado-Medrano V., Barrio-Real L., Gutierrez-Miranda L., Gonzalez-Sarmiento R., Velasco E. A., Kazanietz M. G. & Caloca M. J. (2020), Journal of Biological Chemistry. 295, 5, p. 1300-1314
  • The microbiota programs DNA methylation to control intestinal homeostasis and inflammation

    Authors: Ansari I., Raddatz G., Gutekunst J., Ridnik M., Cohen D., Abu-Remaileh M., Tuganbaev T., Shapiro H., Pikarsky E., Elinav E., Lyko F. & Bergman Y. (2020), Nature Microbiology. 5, 4, p. 610-619
  • HSF1 and Molecular Chaperones in Biology and Cancer

    Authors: Mendillo M. L., Pincus D. & Scherz-Shouval R. (2020),
  • Roles for receptor tyrosine kinases in tumor progression and implications for cancer treatment

    Authors: Ghosh S., Marrocco I. & Yarden Y. (2020), Advances in Cancer Research. Fisher P. B. & Kumar R. (eds.). Vol. 147. p. 1-57
  • Dissecting cellular crosstalk by sequencing physically interacting cells

    Authors: Giladi A., Cohen M., Medaglia C., Baran Y., Li B., Zada M., Bost P., Blecher-Gonen R., Salame T., Mayer J. U., David E., Ronchese F., Tanay A. & Amit I. (2020), Nature Biotechnology. 38, 5, p. 629-637
  • Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

    Authors: McFarland J. M., Paolella B. R., Warren A., Geiger-Schuller K., Shibue T., Rothberg M., Kuksenko O., Colgan W. N., Jones A., Chambers E., Dionne D., Bender S., Wolpin B. M., Ghandi M., Tirosh I., Rozenblatt-Rosen O., Roth J. A., Golub T. R., Regev A., Aguirre A. J., Vazquez F. & Tsherniak A. (2020), Nature Communications. 11, 1, 4296
  • Novel Proteome Extraction Method Illustrates a Conserved Immunological Signature of MSI-H Colorectal Tumors.

    Authors: Vainer E. D., Kania-Almog J., Zatara G., Levin Y. & Vainer G. W. (2020), Molecular & Cellular Proteomics. 19, 10, p. 1619-1631
  • Tumour heterogeneity and the evolutionary trade-offs of cancer

    Authors: Hausser J. & Alon U. (2020), Nature Reviews Cancer. 20, 4, p. 247-257
  • Efficient targeted degradation via reversible and irreversible covalent PROTACs

    Authors: Gabizon R., Shraga A., Gehrtz P., Livnah E., Shorer Y., Gurwicz N., Avram L., Unger T., Aharoni H., Albeck S., Brandis A., Shulman Z., Katz B., Herishanu Y. & London N. (2020), Journal of the American Chemical Society. 142, 27, p. 11734-11742
  • PRMT1 inhibition induces differentiation of colon cancer cells

    Authors: Plotnikov A., Kozer N., Cohen G., Carvalho S., Duberstein S., Almog O., Solmesky L. J., Shurrush K. A., Babaev I., Benjamin S., Gilad S., Kupervaser M., Levin Y., Gershovits M., Ben-Avraham D. & Barr H. M. (2020), Scientific Reports. 10, 1, 20030
  • Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma

    Authors: Chen Y., Yin J., Li W., Li H., Chen D., Zhang C., Lv J., Wang Y., Li X., Li J., Zhang P., Li Y., He Q., Yang X., Lei Y., Tang L., Zhou G., Mao Y., Wei C., Xiong K., Zhang H., Zhu S., Hou Y., Sun Y., Dean M., Amit I., Wu K., Kuang D., Li G., Liu N. & Ma J. (2020), Cell Research. 30, 11, p. 1024-1042
  • Cellular Origins of the Lymphatic Endothelium: Implications for Cancer Lymphangiogenesis: Implications for Cancer Lymphangiogenesis

    Authors: Gutierrez-Miranda L. & Yaniv K. (2020), Frontiers in Physiology. 11, 577584
  • Fluorescent Silica Nanoparticles to Label Metastatic Tumor Cells in Mineralized Bone Microenvironments

    Authors: Chiou A. E., Hinckley J. A., Khaitan R., Varsano N., Wang J., Malarkey H. F., Hernandez C. J., Williams R. M., Estroff L. A., Weiner S., Addadi L., Wiesner U. B. & Fischbach C. (2020), Small. 2001432
  • Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner

    Authors: Barak A. F., Lewinsky H., Perpinial M., Huber V., Radomir L., Kramer M. P., Sever L., Wolf Y., Shapiro M., Herishanu Y., Jung S., Becker-Herman S. & Shachar I. (2020), Oncogene. 39, 9, p. 1997-2008
  • Integration of intra-sample contextual error modeling for improved detection of somatic mutations from deep sequencing

    Authors: Abelson S., Zeng A. G., Nofech-Mozes I., Wang T. T., Ng S. W., Minden M. D., Pugh T. J., Awadalla P., Shlush L. I., Murphy T., Chan S. M., Dick J. E. & Bratman S. V. (2020), Science advances. 6, 50, 3722
  • Donor cell leukemia: reappearance of gene mutations in donor cells - more than an incidental phenomenon?

    Authors: Shahar Gabay T., Chapal-Ilani N., Moskovitz Y., Biezuner T., Oron B., Brilon Y., Fridman-Dror A., Sabah R., Balicer R., Tanay A., Mendelson-Cohen N., Dann E. J., Fineman R., Kaushansky N., Yehudai-Reshef S., Zuckerman T. & Shlush L. I. (2020), Haematologica. 105, 12, p. 2861-2863
  • Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response

    Authors: Vinik Y., Ortega F. G., Mills G. B., Lu Y., Jurkowicz M., Halperin S., Aharoni M., Gutman M. & Lev S. (2020), Science advances. 6, 40, eaba5714
  • STING cyclic dinucleotide sensing originated in bacteria

    Authors: Morehouse B. R., Govande A. A., Millman A., Keszei A. F. A., Lowey B., Ofir G., Shao S., Sorek R. & Kranzusch P. J. (2020), Nature. 586, 7829, p. 429-433
  • Theileria parasites subvert E2F signaling to stimulate leukocyte proliferation

    Authors: Tretina K., Haidar M., Madsen-Bouterse S. A., Sakura T., Mfarrej S., Fry L., Chaussepied M., Pain A., Knowles D. P., Nene V. M., Ginsberg D., Daubenberger C. A., Bishop R. P., Langsley G. & Silva J. C. (2020), Scientific Reports. 10, 1, 3982
  • Hitting KRAS When Its Down

    Authors: Gabizon R. & London N. (2020), Journal of Medicinal Chemistry. 63, 13, p. 6677-6678
  • Manipulation of the human tRNA pool reveals distinct tRNA sets that act in cellular proliferation or cell cycle arrest

    Authors: Aharon-Hefetz N., Frumkin I., Mayshar Y., Dahan O., Pilpel Y. & Rak R. (2020), eLife. 9, e58461
  • Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis

  • Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression

    Authors: Parhi L., Alon-Maimon T., Sol A., Nejman D., Shhadeh A., Fainsod-Levi T., Yajuk O., Isaacson B., Abed J., Maalouf N., Nissan A., Sandbank J., Yehuda-Shnaidman E., Ponath F., Vogel J., Mandelboim O., Granot Z., Straussman R. & Bachrach G. (2020), Nature Communications. 11, 1, 3259
  • The Role of HSF1 and the Chaperone Network in the Tumor Microenvironment

    Authors: Grunberg N., Levi-Galibov O. & Scherz-Shouval R. (2020), HSF1 and Molecular Chaperones in Biology and Cancer. p. 101-111
  • Inflammasome activation and regulation: toward a better understanding of complex mechanisms

    Authors: Zheng D., Liwinski T. & Elinav E. (2020), Cell Discovery. 6, 1, 36
  • PhISCS-BnB: a fast branch and bound algorithm for the perfect tumor phylogeny reconstruction problem

    Authors: Sadeqi Azer E., Rashidi Mehrabadi F., Malikić S., Li X. C., Bartok O., Litchfield K., Levy R., Samuels Y., Schäffer A. A., Gertz E. M., Day C. P., Pérez-Guijarro E., Marie K., Lee M. P., Merlino G., Ergun F. & Sahinalp S. C. (2020), Bioinformatics (Oxford, England). 36, suppl 1, p. i169-i176
  • Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

    Authors: Hoshino A., Kim H. S., Bojmar L., Gyan K. E., Cioffi M., Hernandez J., Zambirinis C. P., Rodrigues G., Molina H., Heissel S., Mark M. T., Steiner L., Benito-Martin A., Lucotti S., Di Giannatale A., Offer K., Nakajima M., Williams C., Nogués L., Pelissier Vatter F. A., Hashimoto A., Davies A. E., Freitas D., Kenific C. M., Ararso Y., Buehring W., Lauritzen P., Ogitani Y., Sugiura K., Takahashi N., Alečković M., Bailey K. A., Jolissant J. S., Wang H., Harris A., Schaeffer L. M., García-Santos G., Posner Z., Balachandran V. P., Khakoo Y., Raju G. P., Scherz A., Sagi I., Scherz-Shouval R., Yarden Y., Oren M., Malladi M., Petriccione M., De Braganca K. C., Donzelli M., Fischer C., Vitolano S., Wright G. P., Ganshaw L., Marrano M., Ahmed A., DeStefano J., Danzer E., Roehrl M. H. A., Lacayo N. J., Vincent T. C., Weiser M. R., Brady M. S., Meyers P. A., Wexler L. H., Ambati S. R., Chou A. J., Slotkin E. K., Modak S., Roberts S. S., Basu E. M., Diolaiti D., Krantz B. A., Cardoso F., Simpson A. L., Berger M., Rudin C. M., Simeone D. M., Jain M., Ghajar C. M., Batra S. K., Stanger B. Z., Bui J., Brown K. A., Rajasekhar V. K., Healey J. H., de Sousa M., Kramer K., Sheth S., Baisch J., Pascual V., Heaton T. E., La Quaglia M. P., Pisapia D. J., Schwartz R., Zhang H., Liu Y., Shukla A., Blavier L., DeClerck Y. A., LaBarge M., Bissell M. J., Caffrey T. C., Grandgenett P. M., Hollingsworth M. A., Bromberg J., Costa-Silva B., Peinado H., Kang Y., Garcia B. A., O'Reilly E. M., Kelsen D., Trippett T. M., Jones D. R., Matei I. R., Jarnagin W. R. & Lyden D. (2020), Cell. 182, 4, p. 1044-1061.e18
  • Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4(+) and PDPN+ CAFs to clinical outcome

    Authors: Friedman G., Levi-Galibov O., David E., Bornstein C., Giladi A., Dadiani M., Mayo A., Halperin C., Pevsner-Fischer M., Lavon H., Mayer S., Nevo R., Stein Y., Balint-Lahat N., Barshack I., Ali H. R., Caldas C., Nili-Gal-Yam E., Alon U., Amit I. & Scherz-Shouval R. (2020), Nature Cancer. 1, p. 692-708
  • Tackling the Many Facets of Glioblastoma Heterogeneity

    Authors: Tirosh I. & Suva M. L. (2020), Cell Stem Cell. 26, 3, p. 303-304
  • Breast cancer associated with paraneoplastic cerebellar degeneration: A case series

    Authors: Vanidassane I., Gogia A., Raina V. & Tiwari P. (2020),
  • Nuclear P38: Roles in Physiological and Pathological Processes and Regulation of Nuclear Translocation

    Authors: Maik-Rachline G., Lifshits L. & Seger R. (2020), International Journal of Molecular Sciences. 21, 17, 6102
  • Less is more: reducing the number of administered chimeric antigen receptor T cells in a mouse model using a mathematically guided approach

    Authors: Globerson Levin A., Kronik N., Shiloach T., Waks T., Eshhar Z. & Vainstein V. (2020), Cancer Immunology Immunotherapy. 69, 7, p. 1165-1175
  • Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors

    Authors: Keshet R., Lee J. S., Adler L., Iraqi M., Ariav Y., Lim L. Q. J., Lerner S., Rabinovich S., Oren R., Katzir R., Tishler H. W., Stettner N., Goldman O., Landesman H., Galai S., Kuperman Y., Kuznetsov Y., Brandis A., Mehlman T., Malitsky S., Itkin M., Koehler S. E., Zhao Y., Talsania K., Shen T., Peled N., Ulitsky I., Porgador A., Ruppin E. & Erez A. (2020), Nature Cancer. 1, 9, p. 894-908
  • Synaptic Protein Degradation Controls Sexually Dimorphic Circuits through Regulation of DCC/UNC-40

    Authors: Salzberg Y., Pechuk V., Gat A., Setty H., Sela S. & Oren-Suissa M. (2020), Current Biology. 30, 21, p. 4128-4141
  • Recent insights into the role of L1CAM in cancer initiation and progression

    Authors: Altevogt P., Ben-Ze'ev A., Gavert N., Schumacher U., Schäfer H. & Sebens S. (2020), International Journal of Cancer. 147, 12, p. 3292-3296
  • Nutrition Regulates Innate Immunity in Health and Disease

    Authors: Nobs S. P., Zmora N. & Elinav E. (2020), Annual Review of Nutrition. 40, p. 189-219
  • Urinary Exosomes from Bladder Cancer Patients Show a Residual Cancer Phenotype despite Complete Pathological Downstaging

    Authors: Hiltbrunner S., Mints M., Eldh M., Rosenblatt R., Holmström B., Alamdari F., Johansson M., Veerman R. E., Winqvist O., Sherif A. & Gabrielsson S. (2020), Scientific Reports. 10, 1, p. 5960-5960, 5960
  • BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression

    Authors: Cohen B., Tempelhof H., Raz T., Oren R., Nicenboim J., Bochner F., Even R., Jelinski A., Eilam R., Ben-Dor S., Adaddi Y., Golani O., Lazar S., Yaniv K. & Neeman M. (2020), Life Science Alliance. 3, 4, e202000666
  • Leptin modulates gene expression in the heart and cardiomyocytes towards mitigating ischemia-induced damage

    Authors: Abd Alkhaleq H., Kornowski R., Waldman M., Levy E., Zemel R., Nudelman V., Shainberg A., Miskin R. & Hochhauser E. (2020), Experimental Cell Research. 397, 2, 112373
  • Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

    Authors: Levi-Galibov O., Lavon H., Wassermann-Dozorets R., Pevsner-Fischer M., Mayer S., Wershof E., Stein Y., Brown L. E., Zhang W., Friedman G., Nevo R., Golani O., Katz L. H., Yaeger R., Laish I., Porco J. A., Sahai E., Shouval D. S., Kelsen D. & Scherz-Shouval R. (2020), Nature Communications. 11, 6245
  • MIBI-TOF: A multiplexed imaging platform relates cellular phenotypes and tissue structure

    Authors: Keren L., Bosse M., Thompson S., Risom T., Vijayaragavan K., McCaffrey E., Marquez D., Angoshtari R., Greenwald N. F., Fienberg H., Wang J., Kambham N., Kirkwood D., Nolan G., Montine T. J., Galli S. J., West R., Bendall S. C. & Angelo M. (2019), Science Advances. 5, 10, 5851
  • Cooperativity between stromal cytokines drives the invasive migration of human breast cancer cells

    Authors: Elisha Y., Sagi Y., Klein G., Straussman R. & Geiger B. (2019), Philosophical Transactions of the Royal Society B: Biological Sciences. 374, 1779, 20180231
  • Author Correction: Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells (Scientific Reports, (2017), 7, 1, (16345), 10.1038/s41598-017-16558-0)

    Authors: Arafeh R., Flores K., Keren-Paz A., Maik-Rachline G., Gutkind N., Rosenberg S., Seger R. & Samuels Y. (2019),
  • Prediction of PD-L1 inhibition effects for HIV-infected individuals

    Authors: Zheltkova V., Argilaguet J., Peligero C., Bocharov G. & Meyerhans A. (2019), PLoS Computational Biology. 15, 11, 1007401
  • A universal anti-cancer vaccine: Chimeric invariant chain potentiates the inhibition of melanoma progression and the improvement of survival

    Authors: Sharbi-Yunger A., Grees M., Cafri G., Bassan D., Eichmuller S. B., Tzehoval E., Utikal J., Umansky V. & Eisenbach L. (2019), International Journal of Cancer. 144, 4, p. 909-921
  • Tumor diversity and the trade-off between universal cancer tasks

    Authors: Hausser J., Szekely P., Bar N., Zimmer A., Sheftel H., Caldas C. & Alon U. (2019), Nature Communications. 10, 5423
  • Imaging of Red-Shifted Light From Bioluminescent Tumors Using Fluorescence by Unbound Excitation From Luminescence

    Authors: Sonego F., Bouccara S., Pons T., Lequeux N., Danckaert A., Tinevez J., Alam I. S., Shorte S. L. & Tournebize R. (2019), Frontiers in Bioengineering and Biotechnology. 7, APR, p. 73, 73
  • Adipocytes sensitize melanoma cells to environmental TGF-beta cues by repressing the expression of miR-211

    Authors: Golan T., Parikh R., Jacob E., Vaknine H., Zemser-Werner V., Hershkovitz D., Malcov H., Leibou S., Reichman H., Sheinboim D., Percik R., Amar S., Brenner R., Greenberger S., Kung A., Khaled M. & Levy C. (2019), Science Signaling. 12, 591, 6847
  • Inhibition of a pancreatic cancer model by cooperative pairs of clinically approved and experimental antibodies

    Authors: Maron R., Schechter B., Nataraj N. B., Ghosh S., Romaniello D., Marrocco I., Noronha A., Carvalho S., Yarden Y. & Sela M. (2019), Biochemical and Biophysical Research Communications. 513, 1, p. 219-225
  • A niche-dependent myeloid transcriptome signature defines dormant myeloma cells

    Authors: Khoo W. H., Ledergor G., Weiner A., Roden D. L., Terry R. L., McDonald M. M., Chai R. C., De Veirman K., Owen K. L., Opperman K. S., Vandyke K., Clark J. R., Seckinger A., Kovacic N., Nguyen A., Mohanty S. T., Pettitt J. A., Xiao Y., Corr A. P., Seeliger C., Novotny M., Lasken R. S., Nguyen T., Oyajobi B. O., Aftab D., Swarbrick A., Parker B., Hewett D. R., Hose D., Vanderkerken K., Zannettino A. C. W., Amit I., Phan T. G. & Croucher P. (2019), Blood. 134, 1, p. 30-43
  • Cancer exome-based identification of tumor neo-antigens using mass spectrometry

  • Immunohistochemical quantification of partial-EMT in oral cavity squamous cell carcinoma primary tumors is associated with nodal metastasis

    Authors: Parikh A. S., Puram S. V., Faquin W. C., Richmon J. D., Emerick K. S., Deschler D. G., Varvares M. A., Tirosh I., Bernstein B. E. & Lin D. T. (2019), Oral Oncology. 99, 104458
  • SLAMF9 regulates pDC homeostasis and function in health and disease

    Authors: Sever L., Radomir L., Strim K., Weiner A., Shchottlender N., Lewinsky H., Barak A. F., Friedlander G., Ben-Dor S., Becker-Herman S. & Shachar I. (2019), Proceedings of the National Academy of Sciences of the United States of America. 116, 33, p. 16489-16496
  • Long Noncoding RNA MALAT1 Regulates Cancer Glucose Metabolism by Enhancing mTOR-Mediated Translation of TCF7L2

    Authors: Malakar P., Stein I., Saragovi A., Winkler R., Stern-Ginossar N., Berger M., Pikarsky E. & Karni R. (2019), Cancer Research. 79, 10, p. 2480-2493
  • Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities

    Authors: Sana G., Madigan J. P., Gartner J. J., Fourrez M., Lin J., Qutob N., Narayan J., Shukla S., Ambudkar S. V., Xia D., Rosenberg S. A., Gottesman M. M., Samuels Y. & Gillet J. (2019), Journal of Investigative Dermatology. 139, 9, p. 1985-1992
  • Forces and constraints controlling podosome assembly and disassembly

    Authors: Rafiq N. B. M., Grenci G., Lim C. K., Kozlov M. M., Jones G. E., Viasnoff V. & Bershadsky A. D. (2019), Philosophical Transactions of the Royal Society B: Biological Sciences. 374, 1779, 20180228
  • SLAMF receptors on normal and malignant B cells

    Authors: Shachar I., Barak A., Lewinsky H., Sever L. & Radomir L. (2019), Clinical Immunology. 204, p. 23-30
  • The cancer microbiome

    Authors: Elinav E., Garrett W. S., Trinchieri G. & Wargo J. (2019), Nature Reviews Cancer. 19, 7, p. 371-376
  • Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges

    Authors: Suva M. L. & Tirosh I. (2019), Molecular Cell. 75, 1, p. 7-12
  • AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer

    Authors: Kubli S. P., Bassi C., Roux C., Wakeham A., Gobl C., Zhou W., Jafari S. M., Snow B., Jones L., Palomero L., Thu K. L., Cassetta L., Soong D., Berger T., Ramachandran P., Baniasadi S. P., Duncan G., Lindzen M., Yarden Y., Herranz C., Lazaro C., Chu M. F., Haight J., Tinto P., Silvester J., Cescon D. W., Petit A., Pettersson S., Pollard J. W., Mak T. W., Pujana M. A., Cappello P. & Gorrini C. (2019), Proceedings of the National Academy of Sciences. 116, 9, p. 3604-3613
  • GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies

    Authors: Simoni-Nieves A., Gerardo-Ramírez M., Pedraza-Vázquez G., Chávez-Rodríguez L., Bucio L., Souza V., Miranda-Labra R. U., Gomez-Quiroz L. E. & Gutiérrez-Ruiz M. C. (2019), Frontiers in Oncology. 9, 1039
  • Deciphering Human Tumor Biology by Single-Cell Expression Profiling

  • Molecular Logic as a Means to Assess Therapeutic Antidotes

    Authors: Unger-Angel L., Motiei L. & Margulies D. (2019), Frontiers in Chemistry. 7, 243
  • PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

    Authors: Rosenzweig N., Dvir-Szternfeld R., Tsitsou-Kampeli A., Keren-Shaul H., Ben-Yehuda H., Weill-Raynal P., Cahalon L., Kertser A., Baruch K., Amit I., Weiner A. & Schwartz M. (2019), Nature Communications. 10, 465
  • PAR1 Expression Predicts Clinical G-CSF CD34+ HSPC Mobilization and Repopulation Potential in Transplanted Patients

    Authors: Nevo N., Zuckerman T., Gur-Cohen S., Kollet O., Avemaria F., Shpall E. J., Mendt M. C., Nagler A., Brenner B., Ben-Arush M. & Lapidot T. (2019), HemaSphere. 3, 5, p. 288-291
  • The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids

    Authors: Seneviratne A. K., Xu M., Henao J. J. A., Fajardo V. A., Hao Z., Voisin V., Xu G. W., Hurren R., Kim S., MacLean N., Wang X., Gronda M., Jeyaraju D., Jitkova Y., Ketela T., Mullokandov M., Sharon D., Thomas G., Chouinard-Watkins R., Hawley J. R., Schafer C., Yau H. L., Khuchua Z., Arnan A., Al-awar R., Gross A., Claypoo S. M., Bazinet R., Lupien M., Chan S., De Carvalho D. D., Minden M. D., Bader G. D., Stark K. D., LeBlanc P. & Schimmer A. D. (2019), Cell Stem Cell. 24, 4, p. 621-636
  • Arginine refolds, stabilizes, and restores function of mutant pVHL proteins in animal model of the VHL cancer syndrome

    Authors: Shmueli M. D., Levy-Kanfo L., Haj E., Schoenfeld A. R., Gazit E. & Segal D. (2019), Oncogene. 38, 7, p. 1038-1049
  • KLF4 sensitizes the colon cancer cell HCT-15 to cisplatin by altering the expression of HMGB1 and hTERT

    Authors: Yadav S. S., Kumar M., Varshney A. & Yadava P. K. (2019), Life Sciences. 220, p. 169-176
  • Leukocyte-specific siRNA delivery revealing IRF8 as a potential anti-inflammatory target

    Authors: Veiga N., Goldsmith M., Diesendruck Y., Ramishetti S., Rosenblum D., Elinav E., Behlke M. A., Benhar I. & Peer D. (2019), Journal of Controlled Release. 313, p. 33-41
  • Kinetic modeling of DUSP regulation in herceptin-resistant HER2-positive breast cancer

    Authors: Buiga P., Elson A., Tabernero L. & Schwartz J. M. (2019), Genes. 10, 8, 568
  • In vivo effects of temperature on the heart and pyloric rhythms in the crab Cancer borealis

    Authors: Kushinsky D., Morozova E. O. & Marder E. (2019), Journal of Experimental Biology. 222, 5, jeb199190.
  • Genome analysis and knowledge-driven variant interpretation with TGex

    Authors: Dahary D., Golan Y., Mazor Y., Zelig O., Barshir R., Twik M., Stein T. I., Rosner G., Kariv R., Chen F., Zhang Q., Shen Y., Safran M., Lancet D. & Fishilevich S. (2019), BMC Medical Genomics. 12, 1, 200
  • The Nuclear Translocation of Mitogen-Activated Protein Kinases: Molecular Mechanisms and Use as Novel Therapeutic Target

    Authors: Flores K., Yadav S. S., Katz A. A. & Seger R. (2019), Neuroendocrinology. 108, 2, p. 121-131
  • Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage

    Authors: Wichert R., Scharfenberg F., Colmorgen C., Koudelka T., Schwarz J., Wetzel S., Potempa B., Potempa J., Bartsch J. W., Sagi I., Tholey A., Saftig P., Rose-John S. & Becker-Pauly C. (2019), FASEB Journal. 33, 11, p. 11925-11940
  • RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction

    Authors: Ptasinska A., Pickin A., Assi S. A., Chin P. S., Ames L., Avellino R., Groeschel S., Delwel R., Cockerill P. N., Osborne C. S. & Bonifer C. (2019), Cell Reports. 28, 12, p. 3022-3031.e7
  • Liver and Steroid Hormones - Can a Touch of p53 Make a Difference?

    Authors: Charni-Natan M., Aloni-Grinstein R., Osher E. & Rotter V. (2019), Frontiers in Endocrinology. 10, 374
  • Genome-wide miRNA methylome analysis in oral cancer: possible biomarkers associated with patient survival

    Authors: Roy R., Chatterjee A., Das D., Ray A., Singh R., Chattopadhyay E., De Sarkar N., Eccles M., Pal M., Maitra A. & Roy B. (2019), Epigenomics. 11, 5, p. 473-487
  • Personalized Nutrition: Are We There Yet?

    Authors: Bashiardes S., Abdeen S. K. & Elinav E. (2019), Journal of Pediatric Gastroenterology and Nutrition. 69, 6, p. 633-638
  • Transient p53-Mediated Regenerative Senescence in the Injured Heart

    Authors: Sarig R., Rimmer R., Bassat E., Zhang L., Umansky K. B., Lendengolts D., Perlmoter G., Yaniv K. & Tzahor E. (2019),
  • Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells (vol 8, 653, 2018): RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells (Scientific Reports, (2018), 8, 1, (653), 10.1038/s41598-017-18851-4)

    Authors: Qutob N., Masuho I., Alon M., Emmanuel R., Cohen I., Di Pizio A., Madore J., Elkahloun A., Ziv T., Levy R., Gartner J. J., Hill V. K., Lin J. C., Hevroni Y., Greenberg P., Brodezki A., Rosenberg S. A., Kosloff M., Hayward N. K., Admon A., Niv M. Y., Scolyer R. A., Martemyanov K. A. & Samuels Y. (2019),
  • Hepatitis C virus core protein interacts with cellular metastasis suppressor Nm23-H1 and promotes cell migration and invasion

    Authors: Paul C., Khera L. & Kaul R. (2019), Archives of Virology. 164, p. 1271-1285
  • Corrigendum to 'p53 balances between tissue hierarchy and anarchy'

    Authors: Koifman G., Aloni-Grinstein R. & Rotter V. (2019),
  • Modelling the role of dual specificity phosphatases in herceptin resistant breast cancer cell lines

    Authors: Buiga P., Elson A., Tabernero L. & Schwartz J. (2019), Computational Biology and Chemistry. 80, p. 138-146
  • Increased expression of cathepsin D is required for L1-mediated colon cancer progression

    Authors: Basu S., Cheriyamundath S., Gavert N., Brabletz T., Haase G. & Ben-Ze'ev A. (2019), Oncotarget. 10, 50, p. 5217-5228
  • The role of the microbiome in NAFLD and NASH

    Authors: Kolodziejczyk A. A., Zheng D., Shibolet O. & Elinav E. (2019), EMBO Molecular Medicine. 11, 2, e9302
  • N-Acetyl-L-Cysteine Supplement in Early Life or Adulthood Reduces Progression of Diabetes in Nonobese Diabetic Mice

    Authors: Frenkel L. A., Rozenfeld H., Rozenberg K., Sampson S. R. & Rosenzweig T. (2019), Current Developments in Nutrition. 3, 4, 097
  • Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

    Authors: Li H., van der Leun A. M., Yofe I., Lubling Y., Gelbard-Solodkin D., van Akkooi A. C. J., van den Braber M., Rozeman E. A., Haanen J. B. A. G., Blank C. U., Horlings H. M., David E., Baran Y., Bercovich A., Lifshitz A., Schumacher T. N., Tanay A. & Amit I. (2019), Cell. 176, 4, p. 775-789.e18
  • Resistance to paclitaxel is associated with a variant of the gene BCL2 in multiple tumor types

    Authors: Ben-Hamo R., Zilberberg A., Cohen H., Bahar-Shany K., Wachtel C., Korach J., Aviel-Ronen S., Barshack I., Barash D., Levanon K. & Efroni S. (2019), npj Precision Oncology. 3, p. 12, 12
  • Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

    Authors: Alieva N. O., Efremov A. K., Hu S., Oh D., Chen Z., Natarajan M., Ong H. T., Jegou A., Romet-Lemonne G., Groves J. T., Sheetz M. P., Yan J. & Bershadsky A. D. (2019), Nature Communications. 10, 3593
  • Molecular pathways of senescence regulate placental structure and function

    Authors: Gal H., Lysenko M., Stroganov S., Vadai E., Youssef S. A., Tzadikevitch-Geffen K., Rotkopf R., Biron-Shental T., de Bruin A., Neeman M. & Krizhanovsky V. (2019), EMBO Journal. 38, 18, 100849
  • Simultaneous Integration of Multi-omics Data Improves the Identification of Cancer Driver Modules

    Authors: Silverbush D., Cristea S., Yanovich-Arad G., Geiger T., Beerenwinkel N. & Sharan R. (2019), Cell Systems. 8, 5, p. 456-466.e5
  • Reduced CTL motility and activity in avascular tumor areas

    Authors: Manaster Y., Shipony Z., Hutzler A., Kolesnikov M., Avivi C., Shalmon B., Barshack I., Besser M. J., Feferman T. & Shakhar G. (2019), Cancer Immunology Immunotherapy. 68, 8, p. 1287-1301
  • The transcriptional profile of circulating myeloid derived suppressor cells correlates with tumor development and progression in mouse

    Authors: Nachmany I., Bogoch Y., Friedlander-Malik G., Amar O., Bondar E., Zohar N., Hantisteanu S., Fainaru O., Lubezky N., Klausner J. M. & Pencovich N. (2019), Genes and Immunity. 20, 7, p. 589-598
  • Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

    Authors: Smillie C. S., Biton M., Ordovas-Montanes J., Sullivan K. M., Burgin G., Graham D. B., Herbst R. H., Rogel N., Slyper M., Waldman J., Sud M., Andrews E., Velonias G., Haber A. L., Jagadeesh K., Vickovic S., Yao J., Stevens C., Dionne D., Nguyen L. T., Villani A., Hofree M., Creasey E. A., Huang H., Rozenblatt-Rosen O., Garber J. J., Khalili H., Desch A. N., Daly M. J., Ananthakrishnan A. N., Shalek A. K., Xavier R. J. & Regev A. (2019), Cell. 178, 3, p. 714-730
  • IKK epsilon regulates the breast cancer stem cell phenotype

    Authors: Orlova Z., Pruefer F., Castro-Oropeza R., Ordaz-Ramos A., Zampedri C., Maldonado V., Vazquez-Santillan K. & Melendez-Zajgla J. (2019), Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 4, p. 598-611
  • c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

    Authors: Sim W. J., Iyengar P. V., Lama D., Lui S. K. L., Ng H. C., Haviv-Shapira L., Domany E., Kappei D., Tan T. Z., Saie A., Jaynes P. W., Verma C. S., Kumar A. P., Rouanne M., Ha H. K., Radulescu C., ten Dijke P., Eichhorn P. J. A. & Thiery J. P. (2019), Nature Communications. 10, 4349
  • Epigenetics and the microbiome

    Authors: Pevsner-Fischer M., Zmora N., Braverman S. & Elinav E. (2019), Handbook of Nutrition, Diet, and Epigenetics. R. Preedy V. & B. Patel V. (eds.). Vol. 1. p. 79-103
  • Pro-inflammatory Cytokines Alter the Immunopeptidome Landscape by Modulation of HLA-B Expression

    Authors: Javitt A., Barnea E., Kramer M. P., Wolf-Levy H., Levin Y., Admon A. & Merbl Y. (2019), Frontiers in Immunology. 10, 10, 141
  • The landscape of tiered regulation of breast cancer cell metabolism

    Authors: Katzir R., Polat I. H., Harel M., Katz S., Foguet C., Selivanov V. A., Sabatier P., Cascante M., Geiger T. & Ruppin E. (2019), Scientific Reports. 9, 1, 17760
  • The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation

    Authors: Swaminathan A., Basu M., Bekri A., Drapeau P. & Kundu T. K. (2019), Frontiers in Molecular Neuroscience. 12, p. 41, 41
  • The ADAM17 Protease Promotes Tobacco Smoke Carcinogen-induced Lung Tumourigenesis

    Authors: Saad M. I., McLeod L., Yu L., Ebi H., Ruwanpura S., Sagi I., Rose-John S. & Jenkins B. J. (2019), Carcinogenesis. 41, 4, p. 527-538
  • The therapeutic potential of tuftsin-phosphorylcholine in giant cell arteritis

    Authors: Croci S., Bonacini M., Muratore F., Caruso A., Fontana A., Boiardi L., Soriano A., Cavazza A., Cimino L., Belloni L., Perry O., Fridkin M., Parmeggiani M., Blank M., Shoenfeld Y. & Salvarani C. (2019), Journal of Autoimmunity. 98, p. 113-121
  • A Mitochondrial VDAC1-Based Peptide Greatly Suppresses Steatosis and NASH-Associated Pathologies in a Mouse Model

    Authors: Pittala S., Krelin Y., Kuperman Y. & Shoshan-Barmatz V. (2019), Molecular Therapy. 27, 10, p. 1848-1862
  • Proteomic and genomic signatures of repeat instability in cancer and adjacent normal tissues

    Authors: Persi E., Prandi D., Wolf Y. I., Pozniak Y., Barnabas G. D., Levanon K., Barshack I., Barbieri C., Gasperini P., Beltran H., Faltas B. M., Rubin M. A., Geiger T., Koonin E. V., Demichelis F. & Horn D. (2019), Proceedings of the National Academy of Sciences - PNAS. 116, 34, p. 16987-16996
  • Proteomic analysis reveals greater abundance of complement and inflammatory proteins in subcutaneous adipose tissue from postpartum cows treated with sodium salicylate

    Authors: Takiya C. S., Montgomery S. R., Mamedova L. K., Kra G., Nemes-Navon N., Levin Y., Fleming S. D., Bradford B. J. & Zachut M. (2019), Journal of Proteomics. 204, 103399
  • A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation

    Authors: Nuta G. C., Gilad Y., Gershoni M., Sznajderman A., Schlesinger T., Bialik S., Eisenstein M., Pietrokovski S. & Kimchi A. (2019), Autophagy. 15, 3, p. 438-452
  • Accelerated Hypofractionated Radiation Therapy for Elderly Frail Bladder Cancer Patients Unfit for Surgery or Chemotherapy

    Authors: Hammer L., Laufer M., Dotan Z., Leibowitz-Amit R., Berger R., Felder S., Weiss I., Lawrence Y. R. & Symon Z. (2019), American Journal Of Clinical Oncology-Cancer Clinical Trials. 42, 2, p. 179-183
  • Cross-Talk between Receptor Tyrosine Kinases AXL and ERBB3 Regulates Invadopodia Formation in Melanoma Cells

    Authors: Revach O., Sandler O., Samuels Y. & Geiger B. (2019), Cancer Research. 79, 10, p. 2634-2648
  • Daily light and darkness onset and circadian rhythms metabolically synchronize hematopoietic stem cell differentiation and maintenance: The role of bone marrow norepinephrine, tumor necrosis factor, and melatonin cycles

    Authors: Golan K., Kollet O., Markus R. P. & Lapidot T. (2019), Experimental Hematology. 78, p. 1-10
  • Expanding the Organismal Proteostasis Network: Linking Systemic Stress Signaling with the Innate Immune Response

    Authors: Miles J., Scherz-Shouval R. & van Oosten-Hawle P. (2019), Trends in Biochemical Sciences. 44, 11, p. 927-942
  • The circRNA-microRNA code: emerging implications for cancer diagnosis and treatment

    Authors: Verduci L., Strano S., Yarden Y. & Blandino G. (2019), Molecular Oncology. 13, 4, p. 669-680
  • Optimizing T-cell receptor avidity with somatic hypermutation

    Authors: Bassan D., Gozlan Y. M., Sharbi-Yunger A., Tzehoval E. & Eisenbach L. (2019), International Journal of Cancer. 145, 10, p. 2816-2826
  • BCR affinity differentially regulates colonization of the subepithelial dome and infiltration into germinal centers within Peyer's patches

    Authors: Biram A., Stromberg A., Winter E., Stoler-Barak L., Salomon R., Addadi Y., Dahan R., Yaari G., Bemark M. & Shulman Z. (2019), Nature Immunology. 20, 4, p. 482-492
  • High efficiency error suppression for accurate detection of low-frequency variants

    Authors: Wang T. T., Abelson S., Zou J., Li T., Zhao Z., Dick J. E., Shlush L. I., Pugh T. J. & Bratman S. V. (2019), Nucleic Acids Research. 47, 15, 87
  • Cancer immunotherapy: The dawn of antibody cocktails

    Authors: Marrocco I., Romaniello D. & Yarden Y. (2019), Human Monoclonal Antibodies. Steinitz M. S. (eds.). p. 11-51
  • Increased Expression of MicroRNA 551a by c-Fos Reduces Focal Adhesion Kinase Levels and Blocks Tumorigenesis

    Authors: Anuj, Arivazhagan L., Venkatraman G. & Rayala S. K. (2019), Molecular and Cellular Biology. 39, 7, UNSP e0057
  • Melanoma-derived extracellular vesicles instigate proinflammatory signaling in the metastatic microenvironment

    Authors: Lahav T. G., Adler O., Zait Y., Shani O., Amer M., Doron H., Abramovitz L., Yofe I., Cohen N. & Erez N. (2019), International Journal of Cancer. 145, 9, p. 2521-2534
  • A new pyrrole based small molecule from Tinospora cordifolia induces apoptosis in MDA-MB-231 breast cancer cells via ROS mediated mitochondrial damage and restoration of p53 activity

    Authors: Rashmi K. C., Harsha Raj M., Paul M., Girish K. S., Salimath B. P. & Aparna H. S. (2019), Chemico-Biological Interactions. 299, p. 120-130
  • Nonmuscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells

    Authors: Halder D., Saha S., Singh R. K., Ghosh I., Mallick D., Dey S. K., Ghosh A., Das B. B., Ghosh S. & Jana S. S. (2019), Molecular Biology of the Cell. 30, 12, p. 1463-1476
  • Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

    Authors: Conniot J., Scomparin A., Peres C., Yeini E., Pozzi S., Matos A., Kleiner R., Moura L. I. F., Zupancic E., Viana A. S., Doron H., Gois P. M. P., Erez N., Jung S., Satchi-Fainaro R. & Florindo H. F. (2019), Nature Nanotechnology. 14, 9, p. 891-901
  • CRISPR/Cas9-based Knockout Strategy Elucidates Components Essential for Type 1 Interferon Signaling in Human HeLa Cells

    Authors: Urin V., Shemesh M. & Schreiber G. (2019), Journal of Molecular Biology. 431, 17, p. 3324-3338
  • p53: not just a tumor suppressor

  • Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis

    Authors: Stein Y., Rotter V. & Aloni-Grinstein R. (2019), International Journal of Molecular Sciences. 20, 24, 6197
  • ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

    Authors: Saad M. I., Alhayyani S., McLeod L., Yu L., Alanazi M., Deswaerte V., Tang K., Jarde T., Smith J. A., Prodanovic Z., Tate M. D., Balic J. J., Watkins D. N., Cain J. E., Bozinovski S., Algar E., Kohmoto T., Ebi H., Ferlin W., Garbers C., Ruwanpura S., Sagi I., Rose-John S. & Jenkins B. J. (2019), EMBO Molecular Medicine. 11, 4, 9976
  • RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma

    Authors: Arafeh R., Di Pizio A., Elkahloun A. G., Dym O., Niv M. Y. & Samuels Y. (2019),
  • UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

    Authors: Jachimowicz R. D., Beleggia F., Isensee J., Velpula B. B., Goergens J., Bustos M. A., Doll M. A., Shenoy A., Checa-Rodriguez C., Wiederstein J. L., Baranes-Bachar K., Bartenhagen C., Hertwig F., Teper N., Nishi T., Schmitt A., Distelmaier F., Lüdecke H., Albrecht B., Krüger M., Schumacher B., Geiger T., Hoon D. S., Huertas P., Fischer M., Hucho T., Peifer M., Ziv Y., Reinhardt H. C., Wieczorek D. & Shiloh Y. (2019), Cell. 176, 3, p. 505-519.e22
  • Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells

    Authors: Diaz-Aragon R., Ramirez-Ricardo J., Cortes-Reynosa P., Simoni-Nieves A., Gomez-Quiroz L. E. & Salazar E. P. (2019), Molecular and Cellular Biochemistry. 457, 1-2, p. 119-132
  • Ser289 phosphorylation activates both DAPK1 and DAPK2 but in response to different intracellular signaling pathways

    Authors: Shiloh R., Bialik S. & Kimchi A. (2019), Cell Cycle. 18, 11, p. 1169-1176
  • Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer

    Authors: Shee K., Jiang A., Varn F. S., Liu S., Traphagen N. A., Owens P., Ma C. X., Hoog J., Cheng C., Golub T. R., Straussman R. & Miller T. W. (2019), FASEB Journal. 33, 2, p. 1644-1657
  • Catalytic degradation of fluorouracil and its derivatives by copper-based nanoparticles

    Authors: Javitt L., Dror I. & Berkowitz B. (2019), Environmental Engineering Science. 36, 12, p. 1466-1473
  • An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

    Authors: Neftel C., Laffy J., Filbin M. G., Hara T., Shore M. E., Rahme G. J., Richman A. R., Silverbush D., Shaw M. L., Hebert C. M., Dewitt J., Gritsch S., Perez E. M., Castro L. N. G., Lan X., Druck N., Rodman C., Dionne D., Kaplan A., Bertalan M. S., Small J., Pelton K., Becker S., Bonal D., Quang-De Nguyen, Servis R. L., Fung J. M., Mylvaganam R., Mayr L., Gojo J., Haberler C., Geyeregger R., Czech T., Slavc I., Nahed B., Curry W. T., Carter B. S., Wakimoto H., Brastianos P. K., Batchelor T. T., Stemmer-Rachamimov A., Martinez-Lage M., Frosch M. P., Stamenkovic I., Riggi N., Rheinbay E., Monje M., Rozenblatt-Rosen O., Cahill D. P., Patel A. P., Hunter T., Verma I. M., Ligon K. L., Louis D. N., Regev A., Bernstein B. E., Tirosh I. & Suva M. L. (2019), Cell. 178, 4, p. 835-849.e21
  • The Immune System Computes the State of the Body: Crowd Wisdom, Machine Learning, and Immune Cell Reference Repertoires Help Manage Inflammation

    Authors: Cohen I. R. & Efroni S. (2019), Frontiers in Immunology. 10, 10
  • ISG15 induction is required during L1-mediated colon cancer progression and metastasis

    Authors: Cheriyamundath S., Basu S., Haase G., Doernberg H., Gavert N., Brabletz T. & Ben-Zeev A. (2019), Oncotarget. 10, 67, p. 7122-7131
  • Single-cell sequencing and its applications in head and neck cancer

    Authors: Qi Z., Barrett T., Parikh A. S., Tirosh I. & Puram S. V. (2019), Oral Oncology. 99, 104441
  • Microvesicle proteomic profiling of uterine liquid biopsy for ovarian cancer early detection

    Authors: Barnabas G. D., Bahar-Shany K., Sapoznik S., Helpman L., Kadan Y., Beiner M., Weitzner O., Arbib N., Korach J., Perri T., Katz G., Blecher A., Brandt B., Friedman E., Stockheim D., Jakobson-Setton A., Eitan R., Armon S., Brand H., Zadok O., Aviel-Ronen S., Harel M., Geiger T. & Levanon K. (2019), Molecular and Cellular Proteomics. 18, 5, p. 865-875
  • Evolutionary trajectory of leukemic clones and its clinical implications

    Authors: Tuval A. & Shlush L. (2019), Haematologica. 104, 5, p. 872-880
  • Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer

    Authors: Maik-Rachline G., Hacohen A. & Seger R. (2019), International Journal of Molecular Sciences. 20, 5, 1194
  • Connections Between Clonal Hematopoiesis, Cardiovascular Disease, and Cancer A Review

    Authors: Calvillo-Arguelles O., Jaiswal S., Shlush L. I., Moslehi J. J., Schimmer A., Barac A. & Thavendiranathan P. (2019), JAMA Cardiology. 4, 4, p. 380-387
  • Effectiveness of the combination of vascular targeted photodynamic therapy and anti-cytotoxic T-lymphocyte-associated antigen 4 in a preclinical mouse model of urothelial carcinoma

    Authors: Corradi R. B., LaRosa S., Jebiwott S., Murray K. S., Rosenzweig B., Somma A. J., Gomez R. S., Scherz A., Kim K. & Coleman J. A. (2019), International Journal of Urology. 26, 3, p. 414-422
  • New insights into YAP/TAZ nucleo-cytoplasmic shuttling: new cancer therapeutic opportunities?

    Authors: Shreberk-Shaked M. & Oren M. (2019), Molecular Oncology. 13, 6, p. 1335-1341
  • Bacillus Calmette-Guerin (BCG) therapy lowers the incidence of Alzheimer's disease in bladder cancer patients

    Authors: Gofrit O. N., Klein B. Y., Cohen I. R., Ben-Hur T., Greenblatt C. L. & Bercovier H. (2019), PLoS ONE. 14, 11, 0224433
  • UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

    Authors: Wolf Y., Bartok O., Patkar S., Eli G. B., Cohen S., Litchfield K., Levy R., Jiménez-Sánchez A., Trabish S., Lee J. S., Karathia H., Barnea E., Day C., Cinnamon E., Stein I., Solomon A., Bitton L., Pérez-Guijarro E., Dubovik T., Shen-Orr S. S., Miller M. L., Merlino G., Levin Y., Pikarsky E., Eisenbach L., Admon A., Swanton C., Ruppin E. & Samuels Y. (2019), Cell. 179, 1, p. 219-235
  • PIK3CA in cancer: The past 30 years

    Authors: Arafeh R. & Samuels Y. (2019), Seminars in Cancer Biology. 59, p. 36-49
  • Scaling laws indicate distinct nucleation mechanisms of holes in the nuclear lamina

    Authors: Deviri D., Pfeifer C. R., Dooling L. J., Ivanovska I. L., Discher D. E. & Safran S. A. (2019), Nature Physics. 15, 8, p. 823-829
  • Transmissible inflammation-induced colorectal cancer in inflammasome-deficient mice

    Authors: Hu B., Friedman G., Elinav E. & Flavell R. A. (2019), OncoImmunology. 8, 10, 981995
  • Exosomes as a storehouse of tissue remodeling proteases and mediators of cancer progression

    Authors: Das A., Mohan V., Krishnaswamy V. R., Solomonov I. & Sagi I. (2019), Cancer and Metastasis Reviews. 38, 3, p. 455-468
  • Modulation of MS-like disease by a multi epitope protein is mediated by induction of CD11c(+) CD1lb(+) Grl(+) myeloid-derived dendritic cells

    Authors: Kaushansky N., Kaminitz A., Allouche-Arnon H. & Ben-Nun A. (2019), Journal of Neuroimmunology. 333, 476953
  • MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy

    Authors: Owyong M., Chou J., van den Bijgaart R. J., Kong N., Efe G., Maynard C., Talmi-Frank D., Solomonov I., Koopman C., Hadler-Olsen E., Headley M., Lin C., Wang C., Sagi I., Werb Z. & Plaks V. (2019), Life Science Alliance. 2, 6, e201800226
  • Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes

    Authors: Sehrawat U., Koning F., Ashkenazi S., Stelzer G., Leshkowitz D. & Dikstein R. (2019), Molecular and Cellular Biology. 39, 3, e00441-18
  • STAT3 Post-Translational Modifications Drive Cellular Signaling Pathways in Prostate Cancer Cells

    Authors: Cocchiola R., Rubini E., Altieri F., Chichiarelli S., Paglia G., Romaniello D., Carissimi S., Giorgi A., Giamogante F., Macone A., Perugia G., Gurtner A. & Eufemi M. (2019), International Journal of Molecular Sciences. 20, 8, 1815
  • Ceramide domains in health and disease: A biophysical perspective

    Authors: Ventura A. E., Mestre B. & Silva L. C. (2019), Advances in Experimental Medicine and Biology. p. 79-108
  • MicroRNAs Affect Complement Regulator Expression and Mitochondrial Activity to Modulate Cell Resistance to Complement-Dependent Cytotoxicity

    Authors: Hillman Y., Mardamshina M., Pasmanik-Chor M., Ziporen L., Geiger T., Shomron N. & Fishelson Z. (2019), Cancer Immunology Research. 7, 12, p. 1970-1983
  • Cholesterol burden in the liver induces mitochondrial dynamic changes and resistance to apoptosis

    Authors: Domínguez-Pérez M., Simoni-Nieves A., Rosales P., Nuño-Lámbarri N., Rosas-Lemus M., Souza V., Miranda R. U., Bucio L., Uribe Carvajal S., Marquardt J. U., Seo D., Gomez-Quiroz L. E. & Gutiérrez-Ruiz M. C. (2019), Journal of Cellular Physiology. 234, 5, p. 7213-7223
  • Converting bleomycin into a prodrug that undergoes spontaneous reactivation under physiological conditions

    Authors: Cooper I., Atrakchi D., Walker M. D., Horovitz A., Fridkin M. & Shechter Y. (2019), Toxicology and Applied Pharmacology. 384, 114782
  • Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

    Authors: Keskin D. B., Anandappa A. J., Sun J., Tirosh I., Mathewson N. D., Li S., Oliveira G., Giobbie-Hurder A., Felt K., Gjini E., Shukla S. A., Hu Z., Li L., Le P. M., Allesoe R. L., Richman A. R., Kowalczyk M. S., Abdelrahman S., Geduldig J. E., Charbonneau S., Pelton K., Iorgulescu J. B., Elagina L., Zhang W., Olive O., McCluskey C., Olsen L. R., Stevens J., Lane W. J., Salazar A. M., Daley H., Wen P. Y., Chiocca E. A., Harden M., Lennon N. J., Gabriel S., Getz G., Lander E. S., Regev A., Ritz J., Neuberg D., Rodig S. J., Ligon K. L., Suva M. L., Wucherpfennig K. W., Hacohen N., Fritsch E. F., Livak K. J., Ott P. A., Wu C. J. & Reardon D. A. (2019), Nature. 565, 7738, p. 234-239
  • REGγ potentiates TGF-β/Smad signal dependent epithelial-mesenchymal transition in thyroid cancer cells

    Authors: Bhatti M. Z., Pan L., Wang T., Shi P. & Li L. (2019), Cellular Signalling. 64, 109412
  • Toward safer haploidnetical hematopoietic stem cell transplantation

    Authors: Sidlik-Muskatel R. & Reisner Y. (2019), Bone Marrow Transplantation. 54, p. 733-737
  • The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

    Authors: De Mattos-Arruda L., Sammut S., Ross E. M., Bashford-Rogers R., Greenstein E., Markus H., Morganella S., Teng Y., Maruvka Y., Pereira B., Rueda O. M., Chin S., Contente-Cuomo T., Mayor R., Arias A., Ali H. R., Cope W., Tiezzi D., Dariush A., Amarante T. D., Reshef D., Ciriaco N., Martinez-Saez E., Peg V., Ramon y Cajal S., Cortes J., Vassiliou G., Getz G., Nik-Zainal S., Murtaza M., Friedman N., Markowetz F., Seoane J. & Caldas C. (2019), Cell Reports. 27, 9, p. 2690-2708
  • Potential immunotherapy for Alzheimer disease and age-related dementia

    Authors: Schwartz M., Arad M. & Ben-Yehuda H. (2019), Dialogues in Clinical Neuroscience. 21, 1, p. 21-25
  • GDF11 exhibits tumor suppressive properties in hepatocellular carcinoma cells by restricting clonal expansion and invasion

    Authors: Gerardo-Ramírez M., Lazzarini-Lechuga R., Hernández-Rizo S., Jiménez-Salazar J. E., Simoni-Nieves A., García-Ruiz C., Fernández-Checa J. C., Marquardt J. U., Coulouarn C., Gutiérrez-Ruiz M. C., Pérez-Aguilar B. & Gomez-Quiroz L. E. (2019), Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 6, p. 1540-1554
  • ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma

    Authors: Srivastava S., Nataraj N. B., Sekar A., Ghosh S., Bornstein C., Drago-Garcia D., Roth L., Romaniello D., Marrocco I., David E., Gilad Y., Lauriola M., Rotkopf R., Kimchi A., Haga Y., Tsutsumi Y., Mirabeau O., Surdez D., Zinovyev A., Delattre O., Kovar H., Amit I. & Yarden Y. (2019), Cell Reports. 29, 1, p. 104-117
  • Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

    Authors: Riquelme E., Zhang Y., Zhang L., Montiel M., Zoltan M., Dong W., Quesada P., Sahin I., Chandra V., San Lucas A., Scheet P., Xu H., Hanash S. M., Feng L., Burks J. K., Do K., Peterson C. B., Nejman D., Tzeng C. D., Kim M. P., Sears C. L., Ajami N., Petrosino J., Wood L. D., Maitra A., Straussman R., Katz M., White J. R., Jenq R., Wargo J. & McAllister F. (2019), Cell. 178, 4, p. 795-806, e1-e12
  • Ribonucleotide reductase from Fusarium oxysporum does not Respond to DNA replication stress

    Authors: Cohen R., Milo S., Sharma S., Savidor A. & Covo S. (2019), DNA Repair. 83, 102674
  • The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells

    Authors: Chan S. M., Sapir T., Park S., Rual J., Contreras-Galindo R., Reiner O. & Markovitz D. M. (2019), PLoS ONE. 14, 2, 0212970
  • Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

    Authors: Ly P., Brunner S. F., Shoshani O., Kim D. H., Lan W., Pyntikova T., Flanagan A. M., Behjati S., Page D. C., Campbell P. J. & Cleveland D. W. (2019), Nature Genetics. 51, 4, p. 705-715
  • Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein

    Authors: Bayart E., Flacco A., Delmas O., Pommarel L., Levy D., Cayallone M., Megnin-Chanet F., Deutsch E. & Malka V. A. (2019), Scientific Reports. 9, 1, 10132
  • Biological implications of clonal hematopoiesis

    Authors: Luis T. C., Wilkinson A. C., Beerman I., Jaiswal S. & Shlush L. (2019), Experimental Hematology. 77, p. 1-5
  • Potentiating vascular-targeted photodynamic therapy through CSF-1R modulation of myeloid cells in a preclinical model of prostate cancer

    Authors: Lebdai S., Gigoux M., Alvim R., Somma A., Nagar K., Azzouzi A. R., Cussenot O., Merghoub T., Wolchok J. D., Scherz A., Kim K. & Coleman J. (2019), OncoImmunology. 8, 6, e1581528
  • Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer

    Authors: Hooda J., Novak M., Salomon M. P., Matsuba C., Ramos R. I., MacDuffie E., Song M., Hirsch M. S., Lester J., Parkash V., Karlan B. Y., Oren M., Hoon D. S. & Drapkin R. (2019), Cancer Research. 79, 4, p. 760-772
  • Mutant p53-a potential player in shaping the tumor-stroma crosstalk

    Authors: Stein Y., Aloni-Grinstein R. & Rotter V. (2019), Journal of Molecular Cell Biology. 11, 7, p. 600-604
  • Self-assembled micellar clusters based on Triton-X-family surfactants for enhanced solubilization, encapsulation, proteins permeability control, and anticancer drug delivery

    Authors: Solomonov A. V., Marfin Y. S., Rumyantsev E. V., Ragozin E., Zahavi T. S., Gellerman G., Tesler A. B., Muench F., Kumagai A. & Miyawaki A. (2019), Materials Science & Engineering: C-Materials For Biological Applications. 99, p. 794-804
  • RUNX represses Pmp22 to drive neurofibromagenesis

    Authors: Hall A., Choi K., Liu W., Rose J., Zhao C., Yu Y., Na Y., Cai Y., Coover R. A., Lin Y., Dombi E., Kim M., Levanon D., Groner Y., Boscolo E., Pan D., Liu P. P., Lu Q. R., Ratner N., Huang G. & Wu J. (2019), Science Advances. 5, 4, 8389
  • p53 balances between tissue hierarchy and anarchy

    Authors: Koifman G., Aloni-Grinstein R. & Rotter V. (2019), Journal of Molecular Cell Biology. 11, 7, p. 553-563
  • Facing the future: challenges and opportunities in adoptive T cell therapy in cancer

    Authors: Magalhaes I., Carvalho-Queiroz C., Hartana C. A., Kaiser A., Lukic A., Mints M., Nilsson O., Grönlund H., Mattsson J. & Berglund S. (2019), Expert Opinion on Biological Therapy. 19, 8, p. 811-827
  • Oxidative stress and therapeutic development in lung cancer

    Authors: Chowdhury A., Sarkar S., Ghosh S., Noronha A., Chakraborti T. & Chakraborti S. (2019), Oxidative Stress in Lung Diseases. Parinandi N. L., Ganguly N. K., Ghosh R., Chakraborti S. & Chakraborti T. (eds.). Vol. 2. p. 427-443
  • The integrated stress response promotes B7H6 expression

    Authors: Obiedat A., Charpak-Amikam Y., Tai-Schmiedel J., Seidel E., Mahameed M., Avril T., Stern-Ginossar N., Springuel L., Bolsee J., Gilham D. E., Dipta P., Shmuel M., Chevet E., Mandelboim O. & Tirosh B. (2019), Journal of Molecular Medicine. 98, 1, p. 135-148
  • Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

    Authors: Harel M., Ortenberg R., Varanasi S. K., Mangalhara K. C., Mardamshina M., Markovits E., Baruch E. N., Tripple V., Arama-Chayoth M., Greenberg E., Shenoy A., Ayasun R., Knafo N., Xu S., Anafi L., Yanovich-Arad G., Barnabas G. D., Ashkenazi S., Besser M. J., Schachter J., Bosenberg M., Shadel G. S., Barshack I., Kaech S. M., Markel G. & Geiger T. (2019), Cell. 179, 1, p. 236-250.e18
  • Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression

    Authors: Luciani G. M., Xie L., Dilworth D., Tierens A., Moskovitz Y., Murison A., Szewczyk M. M., Mitchell A., Lupien M., Shlush L., Dick J. E., Arrowsmith C. H., Barsyte-Lovejoy D. & Minden M. D. (2019), Experimental Hematology. 69, p. 27-36
  • Can immunization with Bacillus Calmette-Guerin (BCG) protect against Alzheimer's disease?

    Authors: Gofrit O. N., Bercovier H., Klein B. Y., Cohen I. R., Ben-Hur T. & Greenblatt C. L. (2019), Medical Hypotheses. 123, p. 95-97
  • Brain and ocular carcinomatosis diagnosed ante-mortem by cerebrospinal fluid and aqueous humor cytology in a dog

    Authors: Rapoport K., Aroch I., Brenner O., Srugo I., Chai O. & Shamir M. H. (2019), Israel Journal of Veterinary Medicine. 74, 4, p. 204-209
  • Global DNA methylation reflects spatial heterogeneity and molecular evolution of lung adenocarcinomas

    Authors: Dietz S., Lifshitz A., Kazdal D., Harms A., Endris V., Winter H., Stenzinger A., Warth A., Sill M., Tanay A. & Sueltmann H. (2019), International Journal of Cancer. 144, 5, p. 1061-1072
  • Hydrophobic Organic Components of Ambient Fine Particulate Matter (PM 2.5) Associated with Inflammatory Cellular Response.

    Authors: Jiang X., Xu F., Qiu X., Shi X., Pardo M., Shang Y., Wang J., Rudich Y. & Zhu T. (2019), Environmental Science & Technology. 53, 17, p. 10479-10486
  • Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer

    Authors: Silberman A., Goldman O., Assayag O. B., Jacob A., Rabinovich S., Adler L., Lee J. S., Keshet R., Sarver A., Frug J., Stettner N., Galai S., Persi E., Halpern K. B., Zaltsman-Amir Y., Pode-Shakked B., Eilam R., Anikster Y., Nagamani S. C. S., Ulitsky I., Ruppin E. & Erez A. (2019), Cancer Research. 79, 3, p. 518-533
  • Prediction of ultra-high-order antibiotic combinations based on pairwise interactions

    Authors: Katzir I., Cokol M., Aldridge B. B. & Alon U. (2019), PLoS Computational Biology. 15, 1, 1006774
  • Data on peptidyl platform-based anticancer drug synthesis and triton-x-based micellar clusters (MCs) self-assembly peculiarities for enhanced solubilization, encapsulation of hydrophobic compounds and their interaction with HeLa cells

    Authors: Solomonov A. V., Marfin Y. S., Rumyantsev E. V., Ragozin E., Zahavi T. S., Gellerman G., Tesler A. B., Muench F., Kumagai A. & Miyawaki A. (2019), Data in Brief. 25, 104052
  • Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression

    Authors: Reznik N., Kozer N., Eisenberg-Lerner A., Barr H., Merbl Y. & London N. (2019), ACS Chemical Biology. 14, 12, p. 2538-2545
  • Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy

    Authors: Lonetto G., Koifman G., Silberman A., Attery A., Solomon H., Levin-Zaidman S., Goldfinger N., Porat Z., Erez A. & Rotter V. (2019), Cell Death and Differentiation. 26, 9, p. 1566-1581
  • p53 and the Viral Connection: Back into the Future

    Authors: Aloni-Grinstein R., Charni-Natan M., Solomon H. & Rotter V. (2018), Cancers. 10, 6, 178
  • Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

    Authors: Ledergor G., Weiner A., Zada M., Wang S., Cohen Y. C., Gatt M. E., Snir N., Magen H., Koren-Michowitz M., Herzog-Tzarfati K., Keren-Shaul H., Bornstein C., Rotkopf R., Yofe I., David E., Yellapantula V., Kay S., Salai M., Ben Yehuda D., Nagler A., Shvidel L., Orr-Urtreger A., Halpern K. B., Itzkovitz S., Landgren O., San-Miguel J., Paiva B., Keats J. J., Papaemmanuil E., Avivi I., Barbash G. I., Tanay A. & Amit I. (2018), Nature Medicine. 24, 12, p. 1867-1876
  • Microglial immune checkpoint mechanisms

    Authors: Deczkowska A., Amit I. & Schwartz M. (2018), Nature Neuroscience. 21, 6, p. 779-786
  • P53 shades of Hippo

    Authors: Furth N., Aylon Y. & Oren M. (2018), Cell Death and Differentiation. 25, p. 81-92
  • The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer

    Authors: Maik-Rachline G., Zehorai E., Hanoch T., Blenis J. & Seger R. (2018), Science Signaling. 11, 525, aao3428
  • Quantitative evaluation of breast cancer response to neoadjuvant chemotherapy by diffusion tensor imaging: Initial results

    Authors: Furman-Haran E., Nissan N., Ricart-Selma V., Martinez-Rubio C., Degani H. & Camps-Herrero J. (2018), Jmri-Journal Of Magnetic Resonance Imaging. 47, 4, p. 1080-1090
  • Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers

    Authors: Solomon H., Dinowitz N., Pateras I. S., Cooks T., Shetzer Y., Molchadsky A., Charni M., Rabani S., Koifman G., Tarcic O., Porat Z., Kogan-Sakin I., Goldfinger N., Oren M., Harris C. C., Gorgoulis V. G. & Rotter V. (2018), Oncogene. 37, 12, p. 1669-1684
  • Does cancer strive to minimize the cost of gene expression?

    Authors: Schirman D., Frumkin I. & Pilpel Y. (2018), Oncotarget. 9, 46, p. 27909-27910
  • Regulation of dual specificity phosphatases in breast cancer during initial treatment with Herceptin: a Boolean model analysis

    Authors: Buiga P., Elson A., Tabernero L. & Schwartz J. (2018), BMC Systems Biology. 12, Suppl 1, p. 13-24, 11
  • Identification of Trophectoderm-Derived Cripto as an Essential Mediator of Embryo Implantation

    Authors: Gershon E., Hadas R., Elbaz M., Booker E., Muchnik M., Kleinjan-Elazary A., Karasenti S., Genin O., Cinnamon Y. & Gray P. C. (2018), Endocrinology. 159, 4, p. 1793-1807
  • Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

    Authors: Yu Y., Schleich K., Yue B., Ji S., Lohneis P., Kemper K., Silvis M. S., Qutob N., van Rooijen E., Werner-Klein M., Li L., Dhawan D., Meierjohann S., Reimann M., Elkahloun A., Treitschke S., Dörken B., Speck C., Mallette F. A., Zon L. I., Holmen S. L., Peeper D. S., Samuels Y., Schmitt C. A. & Lee S. (2018), Cancer Cell. 33, 2, p. 322-336.e8
  • mRNA-seq whole transcriptome profiling of fresh frozen versus archived fixed tissues

    Authors: Ben-Moshe N. B., Gilad S., Perry G., Benjamin S., Balint-Lahat N., Pavlovsky A., Halperin S., Markus B., Yosepovich A., Barshack I., Gal-Yam E. N., Domany E., Kaufman B. & Dadiani M. (2018), BMC Genomics. 19, 1, 419
  • Quantification and tracking of genetically engineered dendritic cells for studying immunotherapy

    Authors: Bar-Shir A., Alon L., Korrer M. J., Lim H. S., Yadav N. N., Kato Y., Pathak A. P., Bulte J. W. M. & Gilad A. A. (2018), Magnetic Resonance in Medicine. 79, 2, p. 1010-1019
  • Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

    Authors: Filbin M. G., Tirosh I., Hovestadt V., Shaw M. L., Escalante L. E., Mathewson N. D., Neftel C., Frank N., Pelton K., Hebert C., Haberler C., Yizhak K., Gojo J., Egervari K., Mount C., van Galen P., Bonal D. M., Quang-De Nguyen, Beck A., Sinai C., Czech T., Dorfer C., Goumnerova L., Lavarino C., Carcaboso A. M., Mora J., Mylvaganam R., Luo C. C., Peyrl A., Popovic M., Azizi A., Batchelor T. T., Frosch M. P., Martinez-Lage M., Kieran M. W., Bandopadhayay P., Beroukhim R., Fritsch G., Getz G., Rozenblatt-Rosen O., Wucherpfennig K. W., Louis D. N., Monje M., Slavc I., Ligon K. L., Golub T. R., Regev A., Bernstein B. E. & Suva M. L. (2018), Science. 360, 6386, p. 331-335
  • Learning by coincidence: Siamese networks and common variable learning

    Authors: Shaham U. & Lederman R. R. (2018), Pattern Recognition. 74, p. 52-63
  • Insulin-induced translocation of IR to the nucleus in insulin responsive cells requires a nuclear translocation sequence

    Authors: Kesten D., Horovitz-Fried M., Brutman-Barazani T. & Sampson S. R. (2018), Biochimica Et Biophysica Acta-Molecular Cell Research. 1865, 4, p. 551-559
  • The Tumor Necrosis Factor Family: Family Conventions and Private Idiosyncrasies

  • Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies

    Authors: Roncato F., Rruga F., Porcu E., Casarin E., Ronca R., Maccarinelli F., Realdon N., Basso G., Alon R., Viola G. & Morpurgo M. (2018), Nature Communications. 9, 1, 4070
  • A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen

    Authors: Amon R., Grant O. C., Ben-Arye S. L., Makeneni S., Nivedha A. K., Marshanski T., Norn C., Yu H., Glushka J. N., Fleishman S. J., Chen X., Woods R. J. & Padler-Karavani V. (2018), Scientific Reports. 8, 10786
  • Mutated MITF-E87R in Melanoma Enhances Tumor Progression via S100A4

    Authors: Nordlinger A., Dror S., Elkahloun A., Del Rio J., Stubbs E., Golan T., Malcov H., Pricket T. D., Cronin J. C., Parikh S., Labes S., Thomas L., Yankovitz G., Tabach Y., Levy C., Samuels Y. & Khaled M. (2018), Journal of Investigative Dermatology. 138, 10, p. 2216-2223
  • Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer

    Authors: Shin S., Müller A., Verma N., Lev S. & Nguyen L. K. (2018), PLoS Computational Biology. 14, 6, 1006192
  • A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

    Authors: Griveau A., Seano G., Shelton S. J., Kupp R., Jahangiri A., Obernier K., Krishnan S., Lindberg O. R., Yuen T. J., Tien A., Sabo J. K., Wang N., Chen I., Kloepper J., Larrouquere L., Ghosh M., Tirosh I., Huillard E., Alvarez-Buylla A., Oldham M. C., Persson A. I., Weiss W. A., Batchelor T. T., Stemmer-Rachamimov A., Suva M. L., Phillips J. J., Aghi M. K., Mehta S., Jain R. K. & Rowitch D. H. (2018), Cancer Cell. 33, 5, p. 874-889
  • Transport of oxaliplatin species in water-saturated natural soil

    Authors: Goykhman N., Dror I. & Berkowitz B. (2018), Chemosphere. 208, p. 829-837
  • Decoding the Information Contained in Fluorophore Radiation Patterns

    Authors: Brunstein M., Salomon A. & Oheim M. (2018), ACS Nano. 12, 12, p. 11725-11730
  • Direct Real-Time Monitoring of Prodrug Activation by Chemiluminescence

    Authors: Gnaim S., Scomparin A., Das S., Blau R., Satchi-Fainaro R. & Shabat D. (2018), Angewandte Chemie - International Edition. 57, 29, p. 9033-9037
  • Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents

    Authors: Geller L. T. & Straussman R. (2018), Molecular and Cellular Oncology. 5, 1, e1405139
  • Gq-Induced Apoptosis is Mediated by AKT Inhibition That Leads to PKC-Induced JNK Activation

    Authors: Nadel G., Yao Z., Ben-Ami I., Naor Z. & Seger R. (2018), Cellular Physiology and Biochemistry. 50, 1, p. 121-135
  • Induction of Nitric-Oxide Metabolism in Enterocytes Alleviates Colitis and Inflammation-Associated Colon Cancer

    Authors: Stettner N., Rosen C., Bernshtein B., Gur-Cohen S., Frug J., Silberman A., Sarver A., Carmel-Neiderman N. N., Eilam R., Biton I., Pevsner-Fischer M., Zmora N., Brandis A., Halpern K. B., Mazkereth R., di Bernardo D., Brunetti-Pierri N., Premkumar M. H., Dank G., Nagamani S. C. S., Jung S., Harmelin A. & Erez A. (2018), Cell Reports. 23, 7, p. 1962-1976
  • Expansion and Antitumor Cytotoxicity of T-Cells Are Augmented by Substrate-Bound CCL21 and Intercellular Adhesion Molecule 1

    Authors: Adutler-Lieber S., Friedman N. & Geiger B. (2018), Frontiers in Immunology. 9, 1303
  • Irreversible modifications of receptor tyrosine kinases

    Authors: Kreitman M., Noronha A. & Yarden Y. (2018), FEBS Letters. 592, 13, p. 2199-2212
  • Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases

  • International conference on Cell Death in Cancer and Toxicology 2018 (CDCT-2018)

    Authors: Ansari K. M., Arany P. R., Arama E., Larisch S., Birge R. B. & Chandra D. (2018), Cell Communication and Signaling. 16, 1, 34
  • Clinical Proteomics of Breast Cancer Reveals a Novel Layer of Breast Cancer Classification

    Authors: Yanovich G., Agmon H., Harel M., Sonnenblick A., Peretz T. & Geiger T. (2018), Cancer research (Chicago, Ill.). 78, 20, p. 6001-6010
  • Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer

    Authors: Shee K., Yang W., Hinds J. W., Hampsch R. A., Varn F. S., Traphagen N. A., Patel K., Cheng C., Jenkins N. P., Kettenbach A. N., Demidenko E., Owens P., Faber A. C., Golub T. R., Straussman R. & Miller T. W. (2018), Journal of Experimental Medicine. 215, 3, p. 895-910
  • Quiescin sulfhydryl oxidase 1 (QSOX1) glycosite mutation perturbs secretion but not Golgi localization

    Authors: Horowitz B., Javitt G., Ilani T., Gat Y., Morgenstern D., Bard F. A. & Fass D. (2018), Glycobiology. 28, 8, p. 580-591
  • Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries

    Authors: Giladi A. & Amit I. (2018), Cell. 172, 1-2, p. 14-21
  • The Proteome of Prostate Cancer Bone Metastasis Reveals Heterogeneity with Prognostic Implications

    Authors: Iglesias-Gato D., Thysell E., Tyanova S., Crnalic S., Santos A., Lima T. S., Geiger T., Cox J., Widmark A., Bergh A., Mann M., Flores-Morales A. & Wikström P. (2018), Clinical Cancer Research. 24, 21, p. 5433-5444
  • Uterine Foxl2 regulates the adherence of the Trophectoderm cells to the endometrial epithelium

    Authors: Elbaz M., Hadas R., Bilezikjian L. M. & Gershon E. (2018), Reproductive Biology and Endocrinology. 16, 12
  • Senescence and Telomere Homeostasis Might Be Involved in Placenta Percreta-Preliminary Investigation

    Authors: Geffen K. T., Gal H., Vainer I., Markovitch O., Amiel A., Krizhanovsky V. & Biron-Shental T. (2018), Reproductive Sciences. 25, 8, p. 1254-1260
  • NKp46 Receptor-Mediated Interferon-gamma Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis

    Authors: Glasner A., Levi A., Enk J., Isaacson B., Viukov S., Orlanski S., Scope A., Neuman T., Enk C. D., Hanna J. H., Sexl V., Jonjic S., Seliger B., Zitvogel L. & Mandelboim O. (2018), Immunity. 48, 1, p. 107-+
  • Analysis of enzymatic activity of matrix metalloproteinase (MMP) by collagen zymography in Melanoma

  • A novel role for the interleukin-1 receptor axis in resistance to anti-EGFR therapy

    Authors: Gelfo V., Mazzeschi M., Grilli G., Lindzen M., Santi S., Duva G., Győrffy B., Ardizzoni A., Yarden Y. & Lauriola M. (2018), Cancers. 10, 10, 355
  • SUSHI: Sparsity-Based Ultrasound Super-Resolution Hemodynamic Imaging

    Authors: Bar-Zion A., Solomon O., Tremblay-Darveau C., Adam D. & Eldar Y. C. (2018), IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 65, 12, p. 2365-2380
  • Randomized Trial of Partial Gland Ablation with Vascular Targeted Phototherapy versus Active Surveillance for Low Risk Prostate Cancer: Extended Followup and Analyses of Effectiveness

    Authors: Gill I. S., Azzouzi A. R., Emberton M., Coleman J. A. & Scherz A. (2018), Journal of Urology. 200, 4, p. 786-793
  • Fresh water, marine and terrestrial cyanobacteria display distinct allergen characteristics

    Authors: Lang-Yona N., Kunert A. T., Vogel L., Kampf C. J., Bellinghausen I., Saloga J., Schink A., Ziegler K., Lucas K., Schuppan D., Poeschl U., Weber B. & Froelich-Nowoisky J. (2018), Science of the Total Environment. 612, p. 767-774
  • The tolerogenic peptide hCDR1 immunomodulates cytokine and regulatory molecule gene expression in blood mononuclear cells of primary Sjogren's syndrome patients

    Authors: Sthoeger Z., Sharabi A., Asher I., Zinger H., Segal R., Shearer G., Elkayam O. & Mozes E. (2018), Clinical Immunology. 192, p. 85-91
  • Ex-vivo organ culture as potential prioritization tool for breast cancer targeted therapy

    Authors: Grinshpun A., Gavert N., Granit R. Z., Masuri H., Ben-Porath I., Breuer S., Zick A., Rosenberg S., Maoz M., Granit A., Pikarsky E., Straussman R., Peretz T. & Sonnenblick A. (2018), Cancer Biology and Therapy. 19, 8, p. 645-648
  • Harnessing synthetic lethality to predict the response to cancer treatment

    Authors: Lee J. S., Das A., Jerby-Arnon L., Arafeh R., Auslander N., Davidson M., McGarry L., James D., Amzallag A., Park S. G., Cheng K., Robinson W., Atias D., Stossel C., Buzhor E., Stein G., Waterfall J. J., Meltzer P. S., Golan T., Hannenhalli S., Gottlieb E., Benes C. H., Samuels Y., Shanks E. & Ruppin E. (2018), Nature Communications. 9, 2546
  • Cell-cell adhesion: linking Wnt/β-catenin signaling with partial EMT and stemness traits in tumorigenesis

    Authors: Basu S., Cheriyamundath S. & Ben-Ze'ev A. (2018), F1000Research. 7, 1488
  • Oncogenic addiction to high 26S proteasome level

    Authors: Tsvetkov P., Adler J., Myers N., Biran A., Reuven N. & Shaul Y. (2018), Cell Death and Disease. 9, 7, 773
  • New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins

    Authors: Golovenko D., Bräuning B., Vyas P., Haran T. E., Rozenberg H. & Shakked Z. (2018), Structure. 26, 9, p. 1237-1250
  • Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis

    Authors: Girbl T., Lenn T., Perez L., Rolas L., Barkaway A., Thiriot A., del Fresno C., Lynam E., Hub E., Thelen M., Graham G., Alon R., Sancho D., von Andrian U. H., Voisin M., Rot A. & Nourshargh S. (2018), Immunity. 49, 6, p. 1062-1076
  • Systemic antitumor immunity by PD-1/PD-L1 inhibition is potentiated by vascular-targeted photodynamic therapy of primary tumors

    Authors: O'Shaughnessy M. J., Murray K. S., La Rosa S. P., Budhu S., Merghoub T., Somma A., Monette S., Kim K., Corradi R. B., Scherz A. & Coleman J. A. (2018), Clinical Cancer Research. 24, 3, p. 592-599
  • Phagocyte-extracellular matrix crosstalk empowers tumor development and dissemination

    Authors: Varol C. & Sagi I. (2018), The FEBS journal. 285, 4, p. 734-751
  • Prediction of acute myeloid leukaemia risk in healthy individuals

    Authors: Abelson S., Collord G., Ng S. W. K., Weissbrod O., Mendelson Cohen N., Niemeyer E., Barda N., Zuzarte P. C., Heisler L., Sundaravadanam Y., Luben R., Hayat S., Wang T. T., Zhao Z., Cirlan I., Pugh T. J., Soave D., Ng K., Latimer C., Hardy C., Raine K., Jones D., Hoult D., Britten A., McPherson J. D., Johansson M., Mbabaali F., Eagles J., Miller J. K., Pasternack D., Timms L., Krzyzanowski P., Awadalla P., Costa R., Segal E., Bratman S. V., Beer P., Behjati S., Martincorena I., Wang J. C. Y., Bowles K. M., Quirós J. R., Karakatsani A., La Vecchia C., Trichopoulou A., Salamanca-Fernández E., Huerta J. M., Barricarte A., Travis R. C., Tumino R., Masala G., Boeing H., Panico S., Kaaks R., Krämer A., Sieri S., Riboli E., Vineis P., Foll M., McKay J., Polidoro S., Sala N., Khaw K., Vermeulen R., Campbell P. J., Papaemmanuil E., Minden M. D., Tanay A., Balicer R. D., Wareham N. J., Gerstung M., Dick J. E., Brennan P., Vassiliou G. S. & Shlush L. I. (2018), Nature. 559, 7714, p. 400-404
  • Medical Cannabis Use by Hodgkin Lymphoma Patients: Experience of a Single Center

    Authors: Sarid N., Zada M., Lev-Ran S., Yashphe E., Givon I., Barzilai M., Perry C., Avivi I. & Wolf I. (2018), Acta Haematologica. 140, 4, p. 194-202
  • Pigment Epithelium-Derived Factor and its Phosphomimetic Mutant Induce JNK-Dependent Apoptosis and P38-Mediated Migration Arrest

    Authors: Konson A., Pradeep S., D'Acunto C. W. & Seger R. (2018), Cellular Physiology and Biochemistry. 49, 2, p. 512-529
  • CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma

    Authors: Alon M., Arafeh R., Lee J. S., Madan S., Kalaora S., Nagler A., Abgarian T., Greenberg P., Ruppin E. & Samuels Y. (2018), Oncotarget. 9, 58, p. 31264-31277
  • Refinement of the endogenous epitope tagging technology allows the identification of a novel NRAS binding partner in melanoma

    Authors: Alon M., Emmanuel R., Qutob N., Bakhman A., Peshti V., Brodezki A., Bassan D., Kosloff M. & Samuels Y. (2018), Pigment Cell and Melanoma Research. 31, 5, p. 641-648
  • Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer

    Authors: Puram S. V., Parikh A. S. & Tirosh I. (2018), Molecular & cellular oncology. 5, 3, e1448244
  • Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016

    Authors: Al Malki M. M., Jones R., Ma Q., Lee D., Reisner Y., Miller J. S., Lang P., Hongeng S., Hari P., Strober S., Yu J., Maziarz R., Mavilio D., Roy D., Bonini C., Champlin R. E., Fuchs E. J. & Ciurea S. O. (2018), Biology of Blood and Marrow Transplantation. 24, 5, p. 895-908
  • Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

    Authors: Lee J. S., Adler L., Karathia H., Carmel N., Rabinovich S., Auslander N., Keshet R., Stettner N., Silberman A., Agemy L., Helbling D., Eilam R., Sun Q., Brandis A., Malitsky S., Itkin M., Weiss H., Pinto S., Kalaora S., Levy R., Barnea E., Admon A., Dimmock D., Stern-Ginossar N., Scherz A., Nagamani S. C. S., Unda M., Wilson D. M., Elhasid R., Carracedo A., Samuels Y., Hannenhalli S., Ruppin E. & Erez A. (2018), Cell. 174, 6, p. 1559-1570
  • Impact of X-irradiation on microglia

    Authors: Menzel F., Kaiser N., Haehnel S., Rapp F., Patties I., Schoeneberg N., Haimon Z., Immig K. & Bechmann I. (2018), GLIA. 66, 1, p. 15-33
  • Dual role of E-cadherin in the regulation of invasive collective migration of mammary carcinoma cells

    Authors: Elisha Y., Kalchenko V., Kuznetsov Y. & Geiger B. (2018), Scientific Reports. 8, 1, 4986
  • PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma

    Authors: Ghannam-Shahbari D., Jacob E., Kakun R. R., Wasserman T., Korsensky L., Sternfeld O., Kagan J., Bublik D. R., Aviel-Ronen S., Levanon K., Sabo E., Larisch S., Oren M., Hershkovitz D. & Perets R. (2018), Oncogene. 37, 17, p. 2213-2224
  • An exploratory study of adolescent response to fluoxetine using psychological and biological predictors

    Authors: Zohar A. H., Eilat T., Amitai M., Taler M., Bari R., Chen A., Apter A., Weizman A. & Fennig S. (2018), PeerJ. 6, 4240
  • Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity

  • A sorafenib-sparing effect in the treatment of thyroid carcinoma cells attained by co-treatment with a novel isoflavone derivative and 1,25 dihydroxyvitamin D3

    Authors: Izkhakov E., Sharon O., Knoll E., Aizic A., Fliss D. M., Kohen F., Stern N. & Somjen D. (2018), Journal of Steroid Biochemistry and Molecular Biology. 182, p. 81-86
  • Molecular mechanisms underlying the role of galectin-8 as a regulator of cancer growth and metastasis

    Authors: Vinik Y., Shatz-Azoulay H. & Zick Y. (2018),
  • Nonredundant, highly connected microRNAs control functionality in breast cancer networks

    Authors: De Anda-Jáuregui G., Espinal-Enríquez J., Drago-García D. & Hernández-Lemus E. (2018), International Journal of Genomics. 2018, 9585383
  • Redox-Active Quinone Chelators: Properties, Mechanisms of Action, Cell Delivery, and Cell Toxicity

    Authors: Polyakov N., Leshina T., Fedenok L., Slepneva I., Kirilyuk I., Furso J., Olchawa M., Sarna T., Elas M., Bilkis I. & Weiner L. (2018), Antioxidants & Redox Signaling. 15, p. 1394-1403
  • Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

    Authors: Kalaora S., Wolf Y., Feferman T., Barnea E., Greenstein E., Reshef D., Tirosh I., Reuben A., Patkar S., Levy R., Quinkhardt J., Omokoko T., Qutob N., Golani O., Zhang J., Mao X., Song X., Bernatchez C., Haymaker C., Forget M., Creasy C., Greenberg P., Carter B. W., Cooper Z. A., Rosenberg S. A., Lotem M., Sahin U., Shakhar G., Ruppin E., Wargo J. A., Friedman N., Admon A. & Samuels Y. (2018), Cancer Discovery. 8, 11, p. 1366-1375
  • A Combination of Approved Antibodies Overcomes Resistance of Lung Cancer to Osimertinib by Blocking Bypass Pathways

    Authors: Romaniello D., Mazzeo L., Mancini M., Marrocco I., Noronha A., Kreitman M., Srivastava S., Ghosh S., Lindzen M., Salame T. M., Onn A., Bar J. & Yarden Y. (2018), Clinical Cancer Research. 24, 22, p. 5610-5621
  • Rewiring urea cycle metabolism in cancer to support anabolism

    Authors: Keshet R., Szlosarek P., Carracedo A. & Erez A. (2018), Nature Reviews Cancer. 18, 10, p. 634-645
  • The Kinetics of Growth of Metallo-supramolecular Polyelectrolytes in Solution

    Authors: Munzert S. M., Stier S. P., Schwarz G., Weissman H., Rybtchinski B. & Kurth D. G. (2018), Chemistry-A European Journal. 24, 12, p. 2898-2912
  • IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer

    Authors: Zhang Y., Wester L., He J., Geiger T., Moerkens M., Siddappa R., Helmijr J. A., Timmermans M. M., Look M. P., van Deurzen C. H. M., Martens J. W. M., Pont C., de Graauw M., Danen E. H. J., Berns E. M. J. J., Meerman J. H. N., Jansen M. P. H. M. & van de Water B. (2018), Oncogene. 37, 14, p. 1869-1884
  • A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation

    Authors: Kotler E., Shani O., Goldfeld G., Lotan-Pompan M., Tarcic O., Gershoni A., Hopf T. A., Marks D. S., Oren M. & Segal E. (2018), Molecular Cell. 71, 1, p. 178-190.e8
  • Patient reported weight loss predicts recurrence rate in renal cell cancer cases after nephrectomy

    Authors: Tiwari P., Kumar L., Thulkar S., Singh G., Malik P. & Seth A. (2018), Asian Pacific Journal of Cancer Prevention. 19, 4, p. 891-895
  • Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

    Authors: Gutjahr J. C., Szenes E., Tschech L., Asslaber D., Schlederer M., Roos S., Yu X., Girbl T., Sternberg C., Egle A., Aberger F., Alon R., Kenner L., Greil R., Orian-Rousseau V. & Hartmann T. N. (2018), Blood. 131, 12, p. 1337-1349
  • A biological-computational human cell lineage discovery platform based on duplex molecular inversion probes

    Authors: Tao L., Raz O., Marx Z., Biezuner T., Amir S., Milo L., Adar R., Onn A., Chapal-Ilani N., Berman V., Levy R., Oron B., Halaban R. & Shapiro E. (2018), BioRxiv.
  • Constricted migration increases DNA damage and independently represses cell cycle

    Authors: Pfeifer C. R., Xia Y., Zhu K., Liu D., Irianto J., Garcia V. M. M., Millan L. M. S., Niese B., Harding S., Deviri D., Greenberg R. A. & Discher D. E. (2018), Molecular Biology of the Cell. 29, 16, p. 1948-1962
  • Differentiation Between Vasogenic Edema and Infiltrative Tumor in Patients With High-Grade Gliomas Using Texture Patch-Based Analysis

    Authors: Artzi M., Liberman G., Blumenthal D. T., Aizenstein O., Bokstein F. & Ben Bashat D. (2018), Jmri-Journal Of Magnetic Resonance Imaging. 48, 3, p. 729-736
  • Quantitative identification of senescent cells in cancer

    Authors: Biran A., Porat Z. & Krizhanovsky V. (2018), Cancer Immunosurveillance. López-Soto A. & R. Folgueras A. (eds.). p. 259-267
  • Loss of C/EBP-beta LIP drives cisplatin resistance in malignant pleural mesothelioma

    Authors: Kopecka J., Salaroglio I. C., Righi L., Libener R., Orecchia S., Grosso F., Milosevic V., Ananthanarayanan P., Ricci L., Capelletto E., Pradotto M., Napoli F., Di Maio M., Novello S., Rubinstein M., Scagliotti G. V. & Riganti C. (2018), Lung Cancer. 120, p. 34-45
  • p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence

    Authors: Sagiv A., Bar-Shai A., Levi N., Hatzav M., Zada L., Ovadya Y., Roitman L., Manella G., Regev O., Majewska J., Vadai E., Eilam R., Feigelson S. W., Tsoory M., Tauc M., Alon R. & Krizhanovsky V. (2018), Cell Reports. 22, 13, p. 3468-3479
  • Frustration-induced phases in migrating cell clusters

    Authors: Copenhagen K., Malet-Engra G., Yu W., Scita G., Gov N. & Gopinathan A. (2018), Science advances. 4, 9, eaar8483
  • Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance

    Authors: Golan K., Kumari A., Kollet O., Khatib-Massalha E., Subramaniam M. D., Ferreira Z. S., Avemaria F., Rzeszotek S., Garcia-Garcia A., Xie S., Flores-Figueroa E., Gur-Cohen S., Itkin T., Ludin-Tal A., Massalha H., Bernshtein B., Ciechanowicz A. K., Brandis A., Mehlman T., Bhattacharya S., Bertagna M., Cheng H., Petrovich-Kopitman E., Janus T., Kaushansky N., Cheng T., Sagi I., Ratajczak M. Z., Mendez-Ferrer S., Dick J. E., Markus R. P. & Lapidot T. (2018), Cell Stem Cell. 23, 4, p. 572-585
  • Androgen deprivation therapy potentiates the efficacy of vascular targeted photodynamic therapy of prostate cancer xenografts

    Authors: Kim K., Watson P. A., Lebdai S., Jebiwott S., Somma A. J., Rosa S. L., Mehta D., Murray K. S., Lilja H., Ulmert D., Monette S., Scherz A. & Coleman J. A. (2018), Clinical Cancer Research. 24, 10, p. 2408-2416
  • Functional characterization of the p53 "mutome"

    Authors: Kotler E., Segal E. & Oren M. (2018), Molecular & cellular oncology. 5, 6, 1511207
  • A modular platform for targeted RNAi therapeutics

    Authors: Kedmi R., Veiga N., Ramishetti S., Goldsmith M., Rosenblum D., Dammes N., Hazan-Halevy I., Nahary L., Leviatan-Ben-Arye S., Harlev M., Behlke M., Benhar I., Lieberman J. & Peer D. (2018), Nature Nanotechnology. 13, p. 214-219
  • Mechanism and medical implications of mammalian autophagy

    Authors: Dikic I. & Elazar Z. (2018), Nature Reviews Molecular Cell Biology. 19, 6, p. 349-364
  • Efficient Therapeutic Protein Expression Using Retroviral Replicating Vector with 2A Peptide in Cancer Models

    Authors: Hofacre A., Yagiz K., Mendoza D., Lopez Espinoza F., Munday A. W., Burrascano C., Singer O., Gruber H. E., Jolly D. J. & Lin A. H. (2018), Human Gene Therapy. 29, 4, p. 437-451
  • Noncontrast Breast MRI During Pregnancy Using Diffusion Tensor Imaging: A Feasibility Study

    Authors: Nissan N., Furman-Haran E., Allweis T., Menes T., Golan O., Kent V., Barsuk D., Paluch-Shimon S., Haas I., Brodsky M., Bordsky A., Granot L. F., Halshtok-Neiman O., Faermann R., Shalmon A., Gotlieb M., Konen E. & Sklair-Levy M. (2018), Journal of Magnetic Resonance Imaging. 49, 2, p. 508-517
  • A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells

    Authors: Koifman G., Shetzer Y., Eizenberger S., Solomon H., Rotkopf R., Molchadsky A., Lonetto G., Goldfinger N. & Rotter V. (2018), Cancer Research. 78, 20, p. 5833-5847
  • LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state

    Authors: Furth N., Pateras I. S., Rotkopf R., Vlachou V., Rivkin I., Schmitt I., Bakaev D., Gershoni A., Ainbinder E., Leshkowitz D., Johnson R. L., Gorgoulis V. G., Oren M. & Aylon Y. (2018), Life science alliance. 1, 5, 201800171
  • Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition

    Authors: Schneidman-Duhovny D., Khuri N., Dong G. Q., Winter M. B., Shifrut E., Friedman N., Craik C. S., Pratt K. P., Paz P., Aswad F. & Sali A. (2018), PLoS ONE. 13, 11, 0206654
  • Positioning Europe for the EPITRANSCRIPTOMICS challenge

    Authors: Jantsch M., Quattrone A., O'Connell M., Helm M., Frye M., Macias-Gonzales M., Ohman M., Ameres S., Willems L., Fuks F., Oulas A., Vanacova S., Nielsen H., Bousquet-Antonelli C., Motorin Y., Roignant J., Balatsos N., Dinnyes A., Baranov P., Kelly V., Lamm A., Rechavi G., Pelizzola M., Liepins J., Holodnuka Kholodnyuk I., Zammit V., Ayers D., Drablos F., Dahl J. A., Bujnicki J., Jeronimo C., Almeida R., Neagu M., Costache M., Bankovic J., Banovic B., Kyselovic J., Valor L. M., Selbert S., Pir P., Demircan T., Cowling V., Schäfer M., Rossmanith W., Lafontaine D., David A., Carre C., Lyko F., Schaffrath R. & Schwartz S. (2018),
  • Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies

    Authors: Gamliel M., Goldman-Wohl D., Isaacson B., Gur C., Stein N., Yamin R., Berger M., Grunewald M., Keshet E., Rais Y., Bornstein C., David E., Jelinski A., Eisenberg I., Greenfield C., Ben-David A., Imbar T., Gilad R., Haimov-Kochman R., Mankuta D., Elami-Suzin M., Amit I., Hanna J. H., Yagel S. & Mandelboim O. (2018), Immunity. 48, 5, p. 951-962.e5
  • Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion

    Authors: Gorelick-Ashkenazi A., Weiss R., Sapozhnikov L., Florentin A., Tarayrah-Ibraheim L., Dweik D., Yacobi-Sharon K. & Arama E. (2018), Nature Communications. 9, 1, 2806
  • Age-related clonal hematopoiesis

    Authors: Shlush L. I. (2018), Blood. 131, 5, p. 496-504
  • Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models

    Authors: Minzel W., Venkatachalam A., Fink A., Hung E., Brachya G., Burstain I., Shaham M., Rivlin A., Omer I., Zinger A., Elias S., Winter E., Erdman P. E., Sullivan R. W., Fung L., Mercurio F., Li D., Vacca J., Kaushansky N., Shlush L., Oren M., Levine R., Pikarsky E., Snir-Alkalay I. & Ben-Neriah Y. (2018), Cell. 175, 1, p. 171-185
  • Increasing intratumor C/EBP- LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer

    Authors: Salaroglio I. C., Gazzano E., Abdullrahman A., Mungo E., Castella B., Abd-elrahman G. E. F. A., Massaia M., Donadelli M., Rubinstein M., Riganti C. & Kopecka J. (2018), Journal Of Experimental & Clinical Cancer Research. 37, 1, 286
  • Generation of reactive oxygen species by photosensitizers and their modes of action on proteins

    Authors: Bilkis I., Silman I. & Weiner L. (2018), Current Medicinal Chemistry. 25, 40, p. 5528-5539
  • The anti-inflammatory IFITM genes ameliorate colitis and partially protect from tumorigenesis by changing immunity and microbiota

    Authors: Alteber Z., Sharbi-Yunger A., Pevsner-Fischer M., Blat D., Roitman L., Tzehoval E., Elinav E. & Eisenbach L. (2018), Immunology and Cell Biology. 96, 3, p. 284-297
  • The immune system profoundly restricts intratumor genetic heterogeneity

    Authors: Milo I., Bedora-Faure M., Garcia Z., Thibaut R., Perie L., Shakhar G., Deriano L. & Bousso P. (2018), Science immunology. 3, 29, 1435
  • Delivery of ROS Generating Anthraquinones Using Reduction-Responsive Peptide-Based Nanoparticles

    Authors: Richard P. U., Craciun I., Gaitzsch J., Weiner L. & Palivan C. G. (2018), Helvetica Chimica Acta. 101, 7, 1800064
  • Helminths-based bi-functional molecule, tuftsin-phosphorylcholine (TPC), ameliorates an established murine arthritis

    Authors: Blank M., Bashi T., Lachnish J., Ben-Ami-Shor D., Shovman O., Fridkin M., Eisenstein M., Volkov A., Barshack I. & Shoenfeld Y. (2018), PLoS ONE. 13, 8, 0200615
  • MRI radiomics analysis of molecular alterations in low-grade gliomas

    Authors: Shofty B., Artzi M., Ben Bashat D., Liberman G., Haim O., Kashanian A., Bokstein F., Blumenthal D. T., Ram Z. & Shahar T. (2018), Computer-Assisted Radiology and Surgery. 13, 4, p. 563-571
  • An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors

    Authors: Mancini M., Gal H., Gaborit N., Mazzeo L., Romaniello D., Salame T. M., Lindzen M., Mahlknecht G., Enuka Y., Burton D. G. A., Roth L., Noronha A., Marrocco I., Adreka D., Altstadter R. E., Bousquet E., Downward J., Maraver A., Krizhanovsky V. & Yarden Y. (2018), EMBO Molecular Medicine. 10, 2, p. 294-308
  • Soluble SLAMF6 Receptor Induces Strong CD8 + T-cell Effector Function and Improves Anti-Melanoma Activity In Vivo

    Authors: Eisenberg G., Engelstein R., Geiger-Maor A., Hajaj E., Merims S., Frankenburg S., Uzana R., Rutenberg A., Machlenkin A., Frei G., Peretz T. & Lotem M. (2018), Cancer Immunology Research. 6, 2, p. 127-138
  • Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer

    Authors: Zupancic E., Curato C., Kim J., Yeini E., Porat Z., Viana A. S., Globerson-Levin A., Waks T., Eshhar Z., Moreira J. N., Satchi-Fainaro R., Eisenbach L., Jung S. & Florindo H. F. (2018), Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 3, p. 835-847
  • The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression

    Authors: Basu S., Gavert N., Brabletz T. & Ben-Ze'ev A. (2018), Cancer Letters. 424, p. 9-18
  • Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

    Authors: Martin D., Degese M. S., Vitale-Cross L., Iglesias-Bartolome R., Valera J. L. C., Wang Z., Feng X., Yeerna H., Vadmal V., Moroishi T., Thorne R. F., Zaida M., Siegele B., Cheong S. C., Molinolo A. A., Samuels Y., Tamayo P., Guan K. L., Lippman S. M., Lyons J. G. & Gutkind J. S. (2018), Nature Communications. 9, 1, 2372
  • Optimized dendritic cell vaccination induces potent CD8 T cell responses and anti-tumor effects in transgenic mouse melanoma models

    Authors: Grees M., Sharbi-Yunger A., Evangelou C., Baumann D., Cafri G., Tzehoval E., Eichmueller S. B., Offringa R., Utikal J., Eisenbach L. & Umansky V. (2018), OncoImmunology. 7, 7, 1445457
  • A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging

    Authors: Keren L., Bosse M., Marquez D., Angoshtari R., Jain S., Varma S., Yang S., Kurian A., Van Valen D., West R., Bendall S. C. & Angelo M. (2018), Cell. 174, 6, p. 1373-1387
  • TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma

    Authors: Jethwa A., Slabicki M., Huellein J., Jentzsch M., Dala V., Rabe S., Wagner L., Walther T., Klapper W., Bohnenberger H., Rettel M., Lu J., Smits A. H., Stein F., Savitski M. M., Huber W., Aylon Y., Oren M. & Zenz T. (2018), Blood. 131, 25, p. 2789-2802
  • Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins

    Authors: Winer H., Fraiberg M., Abada A., Dadosh T., Tamim-Yecheskel B. & Elazar Z. (2018), Nature Communications. 9, 3744
  • Arginine and the metabolic regulation of nitric oxide synthesis in cancer

    Authors: Keshet R. & Erez A. (2018), Disease Models & Mechanisms. 11, 8, dmm033332
  • Intratumor heterogeneity in epigenetic patterns

    Authors: Assenov Y., Brocks D. & Gerhaeuser C. (2018), Seminars in Cancer Biology. 51, p. 12-21
  • The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition

    Authors: Kahlon S., Shreibman D., Unger T., Ben-Yehuda D. & Elias S. (2018),
  • A phase I-II clinical trial of the anti-CD74 monoclonal antibody milatuzumab in frail patients with refractory chronic lymphocytic leukaemia: A patient based approach

    Authors: Haran M., Mirkin V., Braester A., Harpaz N., Shevetz O., Shtreiter M., Greenberg S., Mordich O., Amram O., Binsky-Ehrenreich I., Marom A., Shachar I., Herishanu Y., Ruchlemer R., Berrebi A., Valinsky L., Shtalrid M. & Shvidel L. (2018),
  • Renal cell cancer: Clinicopathological profile and survival outcomes

    Authors: Tiwari P., Kumar L., Singh G., Seth A. & Thulkar S. (2018), Indian Journal of Medical and Paediatric Oncology. 39, 1, p. 23-27
  • LPS-mediated cell surface expression of CD74 promotes the proliferation of B cells in response to MIF

    Authors: Klasen C., Ziehm T., Huber M., Asare Y., Kapurniotu A., Shachar I., Bernhagen J. & El Bounkari O. (2018), Cellular Signalling. 46, p. 32-42
  • The HTLV-1 gp21 fusion peptide inhibits antigen specific T-cell activation in-vitro and in mice

    Authors: Rotem E., Faingold O., Charni M., Klug Y. A., Harari D., Shmuel-Galia L., Nudelman A., Rotter V. & Shai Y. (2018), PLoS Pathogens. 14, 5, e1007044
  • Laplacian pyramid based data fusion for high resolution dynamic MRI

    Authors: Pollack-Zuckerman L., Weizman L., Eldar Y. C., Ben Bashat D., Arzi M. & Irani M. (2018),
  • Brain investigations of rodent disease models by chemical exchange saturation transfer at 21.1T

    Authors: Roussel T., Rosenberg J. T., Grant S. C. & Frydman L. (2018), NMR in Biomedicine. 31, 11, e3995
  • SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors

    Authors: Roth L., Srivastava S., Lindzen M., Sas-Chen A., Sheffer M., Lauriola M., Enuka Y., Noronha A., Mancini M., Lavi S., Tarcic G., Pines G., Nevo N., Heyman O., Ziv T., Rueda O. M., Gnocchi D., Pikarski E., Admon A., Caldas C. & Yarden Y. (2018), Science Signaling. 11, 515, 0949
  • Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner

    Authors: Charni-Natan M., Solomon H., Molchadsky A., Jacob-Berger A., Goldfinger N. & Rotter V. (2018), Cell Death and Disease. 9, 647
  • RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

    Authors: Qutob N., Masuho I., Alon M., Emmanuel R., Cohen I., Di Pizio A., Madore J., Elkahloun A., Ziv T., Levy R., Gartner J. J., Hill V. K., Lin J. C., Hevroni Y., Greenberg P., Brodezki A., Rosenberg S. A., Kosloff M., Hayward N. K., Admon A., Niv M. Y., Scolyer R. A., Martemyanov K. A. & Samuels Y. (2018), Scientific Reports. 8, 1, 653
  • MiRNA-513a-5p inhibits progesterone receptor expression and constitutes a risk factor for breast cancer: The hOrmone and Diet in the ETiology of breast cancer prospective study

    Authors: Muti P., Donzelli S., Sacconi A., Hossain A., Ganci F., Frixa T., Sieri S., Krogh V., Berrino F., Biagioni F., Strano S., Beyene J., Yarden Y. & Blandino G. (2018), Carcinogenesis. 39, 2, p. 98-108
  • Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

    Authors: Galanos P., Pappas G., Polyzos A., Kotsinas A., Svolaki I., Giakoumakis N. N., Glytsou C., Pateras I. S., Swain U., Souliotis V. L., Georgakilas A. G., Geacintov N., Scorrano L., Lukas C., Lukas J., Livneh Z., Lygerou Z., Chowdhury D., Sorensen C. S., Bartek J. & Gorgoulis V. G. (2018), Genome Biology. 19, 1, 37
  • CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia

    Authors: Lewinsky H., Barak A. F., Huber V., Kramer M. P., Radomir L., Sever L., Orr I., Mirkin V., Dezorella N., Shapiro M., Cohen Y., Shvidel L., Seiffert M., Herishanu Y., Becker-Herman S. & Shachar I. (2018), Journal of Clinical Investigation. 128, 12, p. 5465-5478
  • Fas-L promotes the stem cell potency of adipose-derived mesenchymal cells

    Authors: Solodeev I., Meilik B., Volovitz I., Sela M., Manheim S., Yarkoni S., Zipori D., Gur E. & Shani N. (2018), Cell Death and Disease. 9, 695
  • PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein

    Authors: Kedan A., Verma N., Saroha A., Shreberk-Shaked M., Mueller A., Nair N. U. & Lev S. (2018), Cell Death and Disease. 9, 10, p. 985, 985
  • Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features

    Authors: Arandkar S., Furth N., Elisha Y., Belugali Nataraj N., van der Kuip H., Yarden Y., Aulitzky W., Ulitsky I., Geiger B. & Oren M. (2018), Proceedings Of The National Academy Of Sciences Of The United States Of America-Biological Sciences. 115, 25, p. 6410-6415
  • Impaired immune surveillance accelerates accumulation of senescent cells and aging

    Authors: Ovadya Y., Landsberger T., Leins H., Vadai E., Gal H., Biran A., Yosef R., Sagiv A., Agrawal A., Shapira A., Windheim J., Tsoory M., Schirmbeck R., Amit I., Geiger H. & Krizhanovsky V. (2018), Nature Communications. 9, 5435
  • WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice

    Authors: Neuschmelting V., Kim K., Malekzadeh-Najafabadi J., Jebiwott S., Prakash J., Scherz A., Coleman J. A., Kircher M. F. & Ntziachristos V. (2018), Theranostics. 8, 3, p. 723-734
  • Cancer research in the era of immunogenomics

    Authors: Wolf Y. & Samuels Y. (2018), ESMO Open. 3, 7, e000475
  • The PTPROt tyrosine phosphatase functions as an obligate haploinsufficient tumor suppressor in vivo in B-cell chronic lymphocytic leukemia

    Authors: Wakim J., Arman E., Becker Herman S., Kramer M. P., Bakos E., Shachar I. & Elson A. (2017), Oncogene. 36, 26, p. 3686-3694
  • Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis

    Authors: Edison N., Curtz Y., Paland N., Mamriev D., Chorubczyk N., Haviv-Reingewertz T., Kfir N., Morgenstern D., Kupervaser M., Kagan J., Kim H. T. & Larisch S. (2017), Cell Reports. 21, 2, p. 442-454
  • Dynamic proteomics reveals bimodal protein dynamics of cancer cells in response to HSP90 inhibitor

    Authors: Zimmer A., Amar Farkash F. S., Danon T. & Alon U. (2017), BMC Systems Biology. 11, 1, 33
  • Augmented expression of RUNX1 deregulates the global gene expression of U87 glioblastoma multiforme cells and inhibits tumor growth in mice

    Authors: Bogoch Y., Friedlander-Malik G., Lupu L., Bondar E., Zohar N., Langier S., Ram Z., Nachmany I., Klausner J. M. & Pencovich N. (2017), Tumor Biology. 39, 4
  • Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

    Authors: Geller L. T., Barzily-Rokni M., Danino T., Jonas O. H., Shental N., Nejman D., Gavert N., Zwang Y., Cooper Z. A., Shee K., Thaiss C. A., Reuben A., Livny J., Avraham R., Frederick D. T., Ligorio M., Chatman K., Johnston S. E., Mosher C. M., Brandis A., Fuks G., Gurbatri C., Gopalakrishnan V., Kim M., Hurd M. W., Katz M., Fleming J., Maitra A., Smith D. A., Skalak M., Bu J., Michaud M., Trauger S. A., Barshack I., Golan T., Sandbank J., Flaherty K. T., Mandinova A., Garrett W. S., Thayer S. P., Ferrone C. R., Huttenhower C., Bhatia S. N., Gevers D., Wargo J. A., Golub T. R. & Straussman R. (2017), Science. 357, 6356, p. 1156-1160
  • Let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery

    Authors: Spolverini A., Fuchs G., Bublik D. R. & Oren M. (2017), Oncogene. 36, 42, p. 5819-5828
  • Activation of the AktCREB signalling axis by a proline-rich heptapeptide confers resistance to stress-induced cell death and inflammation

    Authors: Herkel J., Schrader J., Erez N., Lohse A. W. & Cohen I. R. (2017), Immunology. 151, 4, p. 474-480
  • Prediction of drug cocktail effects when the number of measurements is limited

    Authors: Zimmer A., Tendler A., Katzir I., Mayo A. & Alon U. (2017), PLoS Biology. 15, 10, e2002518
  • Epigenetic mechanisms underlie the crosstalk between growth factors and a steroid hormone

    Authors: Enuka Y., Feldman M. E., Chowdhury A., Srivastava S., Lindzen M., Sas-Chen A., Massart R., Cheishvili D., Suderman M. J., Zaltsman Y., Mazza C. A., Shukla K., Koerner C., Furth N., Lauriola M., Oren M., Wiemann S., Szyf M. & Yarden Y. (2017), Nucleic Acids Research. 45, 22, p. 1268112699
  • Runx3 in Immunity, Inflammation and Cancer

  • Dermatopontin augments angiogenesis and modulates the expression of transforming growth factor beta 1 and integrin alpha 3 beta 1 in endothelial cells

    Authors: Krishnaswamy V. R., Balaguru U. M., Chatterjee S. & Korrapati P. S. (2017), European Journal of Cell Biology. 93, 3, p. 266-275
  • Diverse p53/DNA binding modes expand the repertoire of p53 response elements

    Authors: Vyas P., Beno I., Xi Z., Stein Y., Golovenko D., Kessler N., Rotter V., Shakked Z. & Haran T. E. (2017), Proceedings of the National Academy of Sciences of the United States of America. 114, 40, p. 10624-10629
  • Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcription and associated T-cell effector functions

    Authors: Schwaderer J., Gaiser A. K., Phan T. S., Delgado M. & Brunner T. (2017), Cell Death and Disease. 8, 4, e2745
  • Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation

    Authors: Wolf Y., Shemer A., Polonsky M., Gross-Vered M., Mildner A., Yona S., David E., Kim K., Goldmann T., Amit I., Heikenwalder M., Nedospasov S., Prinz M., Friedman N. & Jung S. (2017), Journal of Experimental Medicine. 214, 4, p. 905-917
  • A point mutation in the extracellular domain of L1 blocks its capacity to confer metastasis in colon cancer cells via CD10

    Authors: Haase G., Gavert N., Brabletz T. & Ben-Ze'ev A. (2017), Oncogene. 36, 11, p. 1597-1606
  • Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression

    Authors: Glasner A., Isaacson B., Viukov S., Neuman T., Friedman N., Mandelboim M., Sexl V., Hanna J. H. & Mandelboim O. (2017), Scientific Reports. 7, 1, 13090
  • Real Time Laser Speckle Imaging Monitoring Vascular Targeted Photodynamic Therapy

  • A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

    Authors: Boege Y., Malehmir M., Healy M. E., Bettermann K., Lorentzen A., Vucur M., Ahuja A. K., Bohm F., Mertens J. C., Shimizu Y., Frick L., Remouchamps C., Mutreja K., Kaehne T., Sundaravinayagam D., Wolf M. J., Rehrauer H., Koppe C., Speicher T., Padrissa-Altes S., Maire R., Schattenberg J. R. M., Jeong J., Liu L., Zwirner S., Boger R., Hueser N., Davis R. J., Mullhaupt B., Moch H., Schulze-Bergkamen H., Clavien P., Werner S., Borsig L., Luther S. A., Jost P. J., Weinlich R., Unger K., Behrens A., Hillert L., Dillon C., Di Virgilio V. M., Wallach D., Dejardin E., Zender L., Naumann M., Walczak H., Green D. R., Lopes M., Lavrik I., Luedde T., Heikenwalder M. & Weber A. (2017), Cancer Cell. 32, 3, p. 342-359.e10
  • p53 is essential for DNA methylation homeostasis in naive embryonic stem cells, and its loss promotes clonal heterogeneity

    Authors: Tovy A., Spiro A., McCarthy R., Shipony Z., Aylon Y., Allton K., Ainbinder E., Furth N., Tanay A., Barton M. & Oren M. (2017), GENES & DEVELOPMENT. 31, 10, p. 959-972
  • Light-Stimulated Generation of Free Radicals by Quinones-Chelators

    Authors: Markova I. D., Polyakov N. E., Selyutina O. Y., Fedenok L. G., Fedotov K. Y., Slepneva I. A., Leshina T. V., Pokrovsky A. G., Vasilieva N. V. & Weiner L. M. (2017), Zeitschrift Fur Physikalische Chemie-International Journal Of Research In Physical Chemistry & Chemical Physics. 231, 2, p. 369-389
  • Cholesterol overload in the liver aggravates oxidative stressmediated DNA damage and accelerates hepatocarcinogenesis

    Authors: Enríquez-Cortina C., Bello-Monroy O., Rosales-Cruz P., Souza V., Miranda R. U., Toledo-Pérez R., Luna-López A. L., Simoni-Nieves A., Hernández-Pando R., Gutiérrez-Ruiz M. C., Calvisi D. F., Marquardt J. U., Bucio L. & Gomez-Quiroz L. E. (2017), Oncotarget. 8, 61, p. 104136-104148
  • CD84 mediates CLL-microenvironment interactions

    Authors: Marom A., Barak A. F., Kramer M. P., Lewinsky H., Binsky-Ehrenreich I., Cohen S., Tsitsou-Kampeli A., Kalchenko V. (., Kuznetsov Y., Mirkin V., Dezorella N., Shapiro M., Schwartzberg P. L., Cohen Y., Shvidel L., Haran M., Becker Herman S., Herishanu Y. & Shachar I. (2017), Oncogene. 36, 5, p. 628-638
  • The not-so-long history of zebrafish research in Israel

    Authors: Blechman J., Levkowitz G. & Gothilf Y. (2017), International Journal of Developmental Biology. 61, 3-5, p. 149-157
  • Contrast enhanced ultrasound imaging can predict vascular-targeted photodynamic therapy induced tumor necrosis in small animals

    Authors: Comelis F. H., Kim K., Durack J. C., Jebiwott S., Scherz A., Srimathveeravalli G. & Coleman J. A. (2017), Photodiagnosis and Photodynamic Therapy. 20, p. 165-168
  • CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes

    Authors: Dahlhoff M., Gaborit N., Bultmann S., Leonhardt H., Yarden Y. & Schneider M. R. (2017), FEBS Journal. 284, 19, p. 3339-3349
  • Non-canonical NF kappa B mutations reinforce pro-survival TNF response in multiple myeloma through an autoregulatory RelB: p50 NF kappa B pathway

    Authors: Roy P., Mukherjee T., Chatterjee B., Vijayaragavan B., Banoth B. & Basak S. (2017), Oncogene. 36, 10, p. 1417-1429
  • The role of Vimentin in Regulating Cell Invasive Migration in Dense Cultures of Breast Carcinoma Cells

    Authors: Messica Y., Laser-Azogui A., Volberg T., Elisha Y., Lysakovskaia K., Eils R., Gladilin E., Geiger B. & Beck R. (2017), Nano Letters. 17, 11, p. 6941-6948
  • Matrix Mechanosensing: From Scaling Concepts in 'Omics Data to Mechanisms in the Nucleus, Regeneration, and Cancer

    Authors: Discher D. E., Smith L., Cho S., Colasurdo M., Garcia A. J. & Safran S. (2017), Annual Review of Biophysics. 46, p. 295-315
  • The short and the long: non-coding RNAs and growth factors in cancer progression

    Authors: Sas-Chen A., Srivastava S. & Yarden Y. (2017), Biochemical Society Transactions. 45, 1, p. 51-64
  • Biological and clinical consequences of NPM1 mutations in AML

    Authors: Heath E. M., Chan S. M., Minden M. D., Murphy T., Shlush L. I. & Schimmer A. D. (2017), Leukemia. 31, 4, p. 798-807
  • Recent Advances of Individual BODIPY and BODIPY-Based Functional Materials in Medical Diagnostics and Treatment

    Authors: Marfin Y. S., Solomonov A. V., Timin A. S. & Rumyantsev E. V. (2017), Current Medicinal Chemistry. 24, 25, p. 2745-2772
  • P53 on the crossroad between regeneration and cancer

    Authors: Charni M., Aloni-Grinstein R., Molchadsky A. & Rotter V. (2017), Cell Death and Differentiation. 24, 1, p. 8-14
  • The nonreceptor tyrosine kinase c-Src attenuates SCF(β-TrCP) E3-ligase activity abrogating Taz proteasomal degradation

    Authors: Shanzer M., Adler J., Ricardo Lax L. I., Reuven N. & Shaul Y. (2017), Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1678-1683
  • Familial chronic lymphocytic leukemia in Israel: A disproportionate distribution among Ashkenazi Jews

    Authors: Zada M., Lerner D., Piltz Y., Perry C., Avivi I. & Herishanu Y. (2017), European Journal of Haematology. 99, 1, p. 51-55
  • Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues

    Authors: Chai C., Rivkin M., Berkovits L., Simerzin A., Zorde-Khvalevsky E., Rosenberg N., Klein S., Yaish D., Durst R., Shpitzen S., Udi S., Tam J., Heeren J., Worthmann A., Schramm C., Kluwe J., Ravid R., Hornstein E., Giladi H. & Galun E. (2017), Gastroenterology. 153, 5, p. 1404-1415
  • Can immunotherapy treat neurodegeneration?

    Authors: Schwartz M. (2017),
  • From Prokaryotes to Cancer: Glutamine Flux in Multicellular Units

    Authors: Erez A. & Kolodkin-Gal I. (2017), Trends in Endocrinology and Metabolism. 28, 9, p. 637-644
  • Fast Vascular Ultrasound Imaging With Enhanced Spatial Resolution and Background Rejection

    Authors: Bar-Zion A., Tremblay-Darveau C., Solomon O., Adam D. & Eldar Y. C. (2017), IEEE Transactions on Medical Imaging. 36, 1, p. 169-180, 7543469
  • Tumor Suppression by p53: Bring in the Hippo!

    Authors: Aylon Y. & Oren M. (2017),
  • Next-Generation Proteomics and Its Application to Clinical Breast Cancer Research

    Authors: Mardamshina M. & Geiger T. (2017), The American journal of pathology. 187, 10, p. 2175-2184
  • Activation of Signaling Cascades by Weak Extremely Low Frequency Electromagnetic Fields

    Authors: Kapri-Pardes E., Hanoch T., Maik-Rachline G., Murbach M., Bounds P. L., Kuster N. & Seger R. (2017), Cellular Physiology and Biochemistry. 43, 4, p. 1533-1546
  • p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling

    Authors: Yosef R., Pilpel N., Papismadov N., Gal H., Ovadya Y., Vadai E., Miller S., Porat Z., Ben-Dor S. & Krizhanovsky V. (2017), EMBO Journal. 36, 15, p. 2280-2295
  • Immune tolerance induction by nonmyeloablative haploidentical HSCT combining T-cell depletion and posttransplant cyclophosphamide

    Authors: Aversa F., Bachar-Lustig E., Or-Geva N., Prezioso L., Bonomini S., Manfra I., Monti A., Schifano C., Zlotnikov-Klionsky Y., Martelli M. F., Sammarelli G., Sassi M., Soli M., Giuliodori S., Benecchi M., Giuliani N., Lohr F., Pratissoli S. & Reisner Y. (2017), Blood advances. 1, 24, p. 2166-2175
  • Monitoring In-Vivo the Mammary Gland Microstructure during Morphogenesis from Lactation to Post-Weaning Using Diffusion Tensor MRI

    Authors: Nissan N., Furman-Haran E., Shapiro-Feinberg M., Grobgeld D. & Degani H. (2017), Journal of Mammary Gland Biology and Neoplasia. 22, 3, p. 193-202
  • Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells

    Authors: Panayotopoulou E. G., Müller A. K., Börries M., Busch H., Hu G. & Lev S. (2017), Oncotarget. 8, 28, p. 45088-45104
  • Newly formed endothelial cells regulate myeloid cell activity following spinal cord injury via expression of CD200 ligand

    Authors: Cohen M., Ben-Yehuda H., Porat Z., Raposo C., Gordon S. & Schwartz M. (2017), Journal of Neuroscience. 37, 4, p. 972-985
  • Immune deficiency augments the prevalence of p53 loss of heterozygosity in spontaneous tumors but not bi-directional loss of heterozygosity in bone marrow progenitors

    Authors: Shetzer Y., Napchan Y., Kaufman T., Molchadsky A., Tal P., Goldfinger N. & Rotter V. (2017), International Journal of Cancer. 140, 6, p. 1364-1369
  • Quantitative identification of senescent cells in aging and disease

    Authors: Biran A., Zada L., Abou Karam K. P., Vadai E., Roitman L., Ovadya Y., Porat Z. & Krizhanovsky V. (2017), Aging Cell. 16, 4, p. 661-671
  • Paecilomyces as a Cause of Lymph Nodes Enlargement in Hodgkins Lymphoma

    Authors: Tiwari P., Hazarika N., Ahlawat S., Sen I. B. & Shirshi N. (2017),
  • The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element

    Authors: Marín-Béjar O., Mas A. M., González J., Martinez D., Athie A., Morales X., Galduroz M., Raimondi I., Grossi E., Guo S., Rouzaut A., Ulitsky I. & Huarte M. (2017), GENOME BIOLOGY. 18, 1, 202
  • Von Hippel-Lindau and hereditary pheochromocytoma/paraganglioma syndromes: Clinical features, genetics, and surveillance recommendations in childhood

    Authors: Rednam S. P., Erez A., Druker H., Janeway K. A., Kamihara J., Kohlmann W. K., Nathanson K. L., States L. J., Tomlinson G. E., Villani A., Voss S. D., Schiffman J. D. & Wasserman J. D. (2017), Clinical Cancer Research. 23, 12, p. e68-e75
  • Integrating multiple fitting regression and Bayes decision for cancer diagnosis with transcriptomic data from tumor-educated blood platelets

    Authors: Huang G., Yuan M., Chen M., Li L., You W., Li H., Cai J. J. & Ji G. (2017), Analyst. 142, 19, p. 3588-3597
  • Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs

    Authors: Yogev O., Henderson S., Hayes M. J., Marelli S. S., Ofir-Birin Y., Regev-Rudzki N., Herrero J. & Enver T. (2017), PLoS Pathogens. 13, 8, e1006524
  • The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway

    Authors: Furth N. & Aylon Y. (2017), Cell Death and Differentiation. 24, 9, p. 1488-1501
  • Next generation matrix metalloproteinase inhibitors Novel strategies bring new prospects

    Authors: Levin M., Udi Y., Solomonov I. & Sagi I. (2017), Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 11, p. 1927-1939
  • The microbiome in anti-cancer therapy

    Authors: Bashiardes S., Tuganbaev T., Federici S. & Elinav E. (2017), Seminars in Immunology. 32, p. 74-81
  • Pancreatic cancer heterogeneity and response to Mek inhibition

    Authors: Pedersen K., Bilal F., Bernadó Morales C., Salcedo M. T., MacArulla T., Massó-Vallés D., Mohan V., Vivancos A., Carreras M. J., Serres X., Abu-Suboh M., Balsells J., Allende E., Sagi I., Soucek L., Tabernero J. & Arribas J. (2017), Oncogene. 36, 40, p. 5639-5647
  • FXYD5 (dysadherin) may mediate metastatic progression through regulation of the beta-Na+-K+-ATPase subunit in the 4T1 mouse breast cancer model

    Authors: Lubarski-Gotliv I., Dey K., Kuznetsov Y., Kalchenco V., Asher C. & Garty H. (2017), American Journal Of Physiology-Cell Physiology. 313, 1, p. C108-C117
  • Continuous treatment with FTS confers resistance to apoptosis and affects autophagy

    Authors: Schmukler E., Wolfson E., Elazar Z., Kloog Y. & Pinkas-Kramarski R. (2017), PLoS ONE. 12, 2, 0171351
  • Lymphocyte activation gene 3: A novel therapeutic target in chronic lymphocytic leukemia

    Authors: Shapiro M., Herishanu Y., Ben-Zion-Katz, Dezorella N., Sun C., Kay S., Polliack A., Avivi I., Wiestner A. & Perry C. (2017), Haematologica. 102, 5, p. 874-882
  • Targeting of PYK2 synergizes with EGFR antagonists in basal-like TNBC and circumvents HER3-associated resistance via the NEDD4-NDRG1 axis

    Authors: Verma N., Mueller A., Kothari C., Panayotopoulou E., Kedan A., Selitrennik M., Mills G. B., Nguyen L. K., Shin S., Karn T., Holtrich U. & Lev S. (2017), Cancer Research. 77, 1, p. 86-99
  • Classification of high-grade glioma into tumor and nontumor components using support vector machine

    Authors: Blumenthal D. T., Artzi M., Liberman G., Bokstein F., Aizenstein O. & Ben Bashat B. D. (2017), American Journal of Neuroradiology. 38, 5, p. 908-914
  • Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival

    Authors: Bublik D. R., Bursac S., Sheffer M., Orsolic I., Shalit T., Tarcic O., Kotler E., Mouhadeb O., Hoffman Y., Fuchs G., Levin Y., Volarevic S. & Oren M. (2017), Proceedings of the National Academy of Sciences of the United States of America. 114, 4, p. E496-E505
  • McPAS-TCR: A manually curated catalogue of pathology-associated T cell receptor sequences

    Authors: Tickotsky N., Sagiv T., Prilusky J., Shifrut E. & Friedman N. (2017), Bioinformatics. 33, 18, p. 2924-2929
  • SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress

    Authors: Zipin-Roitman A., Aqaqe N., Yassin M., Biechonski S., Amar M., van Delft D. M. F., Gan O. I., McDermott S. P., Buzina A., Ketela T., Shlush L. I., Xie S., Voisin V., Moffat J., Minden M. D., Dick J. E. & Milyavsky M. (2017), Oncotarget. 8, 10, p. 16712-16727
  • Cancer and central nervous system tumor surveillance in pediatric neurofibromatosis 1

    Authors: Evans D. G. R., Salvador H., Chang V. Y., Erez A., Voss S. D., Schneider K. W., Scott H. S., Plon S. E. & Tabori U. (2017), Clinical Cancer Research. 23, 12, p. e46-e53
  • Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

    Authors: Lavin Y., Kobayashi S., Leader A., Amir E. D., Elefant N., Bigenwald C., Remark R., Sweeney R., Becker C. D., Levine J. H., Meinhof K., Chow A., Kim-Shulze S., Wolf A., Medaglia C., Li H., Rytlewski J. A., Emerson R. O., Solovyov A., Greenbaum B. D., Sanders C., Vignali M., Beasley M. B., Flores R., Gnjatic S., Pe'er D., Rahman A., Amit I. & Merad M. (2017), Cell. 169, 4, p. 750-765.e17
  • Optimization of two-compartment-exchange-model analysis for dynamic contrast-enhanced mri incorporating bolus arrival time

    Authors: Nadav G., Liberman G., Artzi M., Kiryati N. & Bashat D. B. (2017), Journal of Magnetic Resonance Imaging. 45, 1, p. 237-249
  • Pyruvate dehydrogenase has a major role in mast cell function, and its activity is regulated by mitochondrial microphthalmia transcription factor

    Authors: Sharkia I., Hadad Erlich T., Landolina N., Assayag M., Motzik A., Rachmin I., Kay G., Porat Z., Tshori S., Berkman N., Levi-Schaffer F. & Razin E. (2017), Journal of Allergy and Clinical Immunology. 140, 1, p. 204-214.e8
  • BCAT1 restricts alpha KG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

    Authors: Raffel S., Falcone M., Kneisel N., Hansson J., Wang W., Lutz C., Bullinger L., Poschet G., Nonnenmacher Y., Barnert A., Bahr C., Zeisberger P., Przybylla A., Sohn M., Toenjes M., Erez A., Adler L., Jensen P., Scholl C., Froehling S., Cocciardi S., Wuchter P., Thiede C., Floercken A., Westermann J., Ehninger G., Lichter P., Hiller K., Hell R., Herrmann C., Ho A. D., Krijgsveld J., Radlwimmer B. & Trumpp A. (2017), Nature. 551, 7680, p. 384-388
  • p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis

    Authors: Napoletano F., Gibert B., Yacobi-Sharon K., Vincent S., Favrot C., Mehlen P., Girard V., Teil M., Chatelain G., Walter L., Arama E. & Mollereau B. (2017), PLoS Genetics. 13, 9, e1007024
  • Diffusion-Weighted Breast MRI: Clinical Applications and Emerging Techniques

    Authors: Partridge S. C., Nissan N., Rahbar H., Kitsch A. E. & Sigmund E. E. (2017), Journal of Magnetic Resonance Imaging. 45, 2, p. 337-355
  • Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells

    Authors: Arafeh R., Flores K., Keren-Paz A., Maik-Rachline G., Gutkind N., Rosenberg S., Seger R. & Samuels Y. (2017), Scientific Reports. 7, 16345
  • A recombinant fungal compound induces anti-proliferative and pro-apoptotic effects on colon cancer cells

    Authors: Nimri L., Spivak O., Tal D., Schälling D., Peri I., Graeve L., Salame T. M., Yarden O., Hadar Y. & Schwartz B. (2017), Oncotarget. 8, 17, p. 28854-28864
  • C/EBP beta LIP augments cell death by inducing osteoglycin

    Authors: Wassermann Dozorets D. R. & Rubinstein M. (2017), Cell Death & Disease. 8, 2733
  • Death by over-eating: The Gaucher disease associated gene GBA1, identified in a screen for mediators of autophagic cell death, is necessary for developmental cell death in Drosophila midgut

    Authors: Dasari S. K., Schejter E., Bialik S., Shkedy A., Levin-Salomon V., Levin-Zaidman S. & Kimchi A. (2017), Cell Cycle. 16, 21, p. 2003-2010
  • Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

    Authors: Arkadash V., Yosef G., Shirian J., Cohen I., Horev Y., Grossman M., Sagi I., Radisky E. S., Shifman J. M. & Papo N. (2017), Journal of Biological Chemistry. 292, 8, p. 3481-3495
  • Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases

    Authors: Rachman-Tzemah C., Zaffryar-Eilot S., Grossman M., Ribero D., Timaner M., Mäki J. M., Myllyharju J., Bertolini F., Hershkovitz D., Sagi I., Hasson P. & Shaked Y. (2017), Cell Reports. 19, 4, p. 774-784
  • Reduced changes in protein compared to mRNA levels across non-proliferating tissues

    Authors: Perl K., Ushakov K., Pozniak Y., Yizhar-Barnea O., Bhonker Y., Shivatzki S., Geiger T., Avraham K. B. & Shamir R. (2017), BMC Genomics. 18, 1, 305
  • Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq

    Authors: Medaglia C., Giladi A., Stoler-Barak L., De Giovanni M., Salame T. M., Biram A., David E., Li H., Iannacone M., Shulman Z. & Amit I. (2017), Science. 358, 6370, p. 1622-1626
  • Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis

    Authors: Procaccia S., Ordan M., Cohen I., Bendetz-Nezer S. & Seger R. (2017), Scientific Reports. 7, 43078
  • miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis

    Authors: Kfir-Erenfeld S., Haggiag N., Biton M., Stepensky P., Assayag-Asherie N. & Yefenof E. (2017), Oncotarget. 8, 1, p. 472-489
  • Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome

    Authors: Schwartzman O., Savino A. M., Gombert M., Palmi C., Cario G., Schrappe M., Eckert C., von Stackelberg A., Huang J., Hameiri-Grossman M., Avigad S., te Kronnie G., Geron I., Birger Y., Rein A., Zarfati G., Fischer U., Mukamel Z., Stanulla M., Biondi A., Cazzaniga G., Vetere A., Wagner B. K., Chen Z., Chen S., Tanay A., Borkhardt A. & Izraeli S. (2017), Proceedings Of The National Academy Of Sciences Of The United States Of America-Physical Sciences. 114, 20, p. E4030-E4039
  • Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

    Authors: Puram S. V., Tirosh I., Parikh A. S., Patel A. P., Yizhak K., Gillespie S., Rodman C., Luo C. L., Mroz E. A., Emerick K. S., Deschler D. G., Varvares M. A., Mylvaganam R., Rozenblatt-Rosen O., Rocco J. W., Faquin W. C., Lin D. T., Regev A. & Bernstein B. E. (2017), Cell. 171, 7, p. 1611-1624.e24
  • PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy

    Authors: Salaroglio I. C., Panada E., Moiso E., Buondonno I., Provero P., Rubinstein M., Kopecka J. & Riganti C. (2017), Molecular Cancer. 16, 1, 91
  • Synthesis and biological evaluation of novel isoxazolines linked via piperazine to 2- benzoisothiazoles as potent apoptotic agents

    Authors: Byrappa S., Harsha Raj M., Kungyal T., Kudva N N. U., Salimath B. P. & Lokanatha Rai K. M. (2017), European Journal of Medicinal Chemistry. 126, p. 218-224
  • Synonymous Somatic Variants in Human Cancer Are Not Infamous: A Plea for Full Disclosure in Databases and Publications

    Authors: Soussi T., Taschner P. E. M. & Samuels Y. (2017), Human Mutation. 38, 4, p. 339-342
  • Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase

    Authors: Cingolani F., Simbari F., Luis Abad A. J., Casasampere M., Fabrias G., Futerman A. H. & Casas J. (2017), Journal of Lipid Research. 58, 8, p. 1500-1513
  • Tracing the origins of relapse in acute myeloid leukaemia to stem cells

    Authors: Shlush L. I., Mitchell A., Heisler L., Abelson S., Ng S. W. K., Trotman-Grant A., Medeiros J. J. F., Rao-Bhatia A., Jaciw-Zurakowsky I., Marke R., McLeod J. L., Doedens M., Bader G., Voisin V., Xu C., McPherson J. D., Hudson T. J., Wang J. C. Y., Minden M. D. & Dick J. E. (2017), Nature. 547, 7661, p. 104-108
  • Bombesin antagonist-based radiotherapy of prostate cancer combined with WST-11 vascular targeted photodynamic therapy

    Authors: Kim K., Zhang H., La Rosa R. S., Jebiwott S., Desai P., Kimm S., Scherz A., O'Donoghue J. A., Weber W. A. & Coleman J. A. (2017), Clinical Cancer Research. 23, 13, p. 3343-3351
  • Suppression of VEGF-induced angiogenesis and tumor growth by Eugenia jambolana, Musa paradisiaca, and Coccinia indica extracts

    Authors: Raj M. H., Ghosh D., Banerjee R. & Salimath B. P. (2017), Pharmaceutical Biology. 55, 1, p. 1489-1499
  • Spontaneous Activation of Antigen-presenting Cells by Genes Encoding Truncated Homo-Oligomerizing Derivatives of CD40

    Authors: Levin N., Pato A., Cafri G., Eisenberg G., Peretz T., Margalit A., Lotem M. & Gross G. (2017), Journal of Immunotherapy. 40, 2, p. 39-50
  • Post-translational regulation of p53 function through 20S proteasome-mediated cleavage

    Authors: Solomon H., Brauning B., Fainer I., Ben-Nissan G., Rabani S., Goldfinger N., Moscovitz O., Shakked Z., Rotter V. & Sharon M. (2017), Cell Death and Differentiation. 24, p. 2187-2198
  • Pancreatic cancer ascites xenograft-an expeditious model mirroring advanced therapeutic resistant disease

    Authors: Golan T., Stossel C., Schvimer M., Atias D., Halperin S., Buzhor E., Raitses Gurevich G. M., Cohen K., Pri-Chen S., Wilson J., Denroche R. E., Lungu I., Bartlett J. M. S., Mbabaali F., Yarden Y., Nataraj N. B., Gallinger S. & Berger R. (2017), Oncotarget. 8, 25, p. 40778-40790
  • Cancer and central nervous system tumor surveillance in pediatric neurofibromatosis 2 and related disorders

    Authors: Evans D. G. R., Salvador H., Chang V. Y., Erez A., Voss S. D., Druker H., Scott H. S. & Tabori U. (2017), Clinical Cancer Research. 23, 12, p. e54-e61
  • The cancer paradigms of mammalian regeneration: Can mammals regenerate as amphibians?

    Authors: Sarig R. & Tzahor E. (2017), Carcinogenesis. 38, 4, p. 359-366
  • TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response

    Authors: Isaac R., Goldstein I., Furth N., Zilber N., Streim S., Boura-Halfon S., Elhanany E., Rotter V., Oren M. & Zick Y. (2017), Cell Death and Differentiation. 24, 1, p. 132-143
  • Involvement of Rho GAP GRAF1 in maintenance of epithelial phenotype

    Authors: Regev M., Sabanay H., Kartvelishvily E., Kam Z. & Bershadsky A. D. (2017), Cell Adhesion and Migration. 11, 4, p. 367-383
  • The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals

    Authors: Lahiani A., Yavin E. & Lazarovici P. (2017), Toxins. 9, 3, 107
  • AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia

    Authors: Zhou F., Liu Y., Rohde C., Pauli C., Gerloff D., Koehn M., Misiak D., Baeumer N., Cui C., Goellner S., Oellerich T., Serve H., Garcia-Cuellar M., Slany R., Maciejewski J. P., Przychodzen B., Seliger B., Klein H., Bartenhagen C., Berdel W. E., Dugas M., Taketo M. M., Farouq D., Schwartz S., Regev A., Hebert J., Sauvageau G., Pabst C., Huettelmaier S. & Mueller-Tidow C. (2017), Nature Cell Biology. 19, 7, p. 844-855
  • T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences

    Authors: Madi A., Poran A., Shifrut E., Reich-Zeliger S., Greenstein E., Zaretsky I., Arnon T., Van Laethem L. F., Singer A., Lu J., Sun P. D., Cohen I. R. & Friedman N. (2017), eLife. 6, e22057
  • The Leo Sachs legacy: A pioneers journey through hematopoiesis

  • Genetic and Functional Analysis of GRIN2A in Tumor Samples

    Authors: Prickett T. D., Gartner J. J. & Samuels Y. (2017), NMDA Receptors. p. 93-116
  • Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression

    Authors: Fiziev P., Akdemir K. C., Miller J. P., Keung E. Z., Samant N. S., Sharma S., Natale C. A., Terranova C. J., Maitituoheti M., Amin S. B., Martinez-Ledesma E., Dhamdhere M., Axelrad J. B., Shah A., Cheng C. S., Mahadeshwar H., Seth S., Barton M. C., Protopopov A., Tsai K. Y., Davies M. A., Garcia B. A., Amit I., Chin L., Ernst J. & Rai K. (2017), Cell Reports. 19, 4, p. 875-889
  • Mast cell tumour in the third eyelid of a mare

    Authors: Shnaiderman-Torban A., Tatz A., Oreff G., Brenner O., Dahan R., Ofri R. & Kelmer G. (2017), Equine Veterinary Education. 29, 12, p. 659-663
  • Diverse continuum of CD4+ T-cell states is determined by hierarchical additive integration of cytokine signals

    Authors: Eizenberg-Magar I., Rimer J., Zaretsky I., Lara-Astiaso D., Reich-Zeliger S. & Friedman N. (2017), Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. E6447-E6456
  • Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming

    Authors: Zupančič E., Curato C., Paisana M., Rodrigues C., Porat Z., Viana A. S., Afonso C. A., Pinto J., Gaspar R., Moreira J. N., Satchi-Fainaro R., Jung S. & Florindo H. F. (2017), Journal of Controlled Release. 258, p. 182-195
  • EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells

    Authors: Wanke F., Moos S., Croxford A. L., Heinen A. P., Graef S., Kalt B., Tischner D., Zhang J., Christen I., Bruttger J., Yogev N., Tang Y., Zayoud M., Israel N., Karram K., Reissig S., Lacher S. M., Reichhold C., Mufazalov I. A., Ben-Nun A., Kuhlmann T., Wettschureck N., Sailer A. W., Rajewsky K., Casola S., Waisman A. & Kurschus F. C. (2017), Cell Reports. 18, 5, p. 1270-1284
  • Microbiome at the Frontier of Personalized Medicine

    Authors: Kashyap P. C., Chia N., Nelson H., Segal E. & Elinav E. (2017), Mayo Clinic Proceedings. 92, 12, p. 1855-1864
  • Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function

    Authors: Gropper Y., Feferman T., Shalit T., Salame T. M., Porat Z. & Shakhar G. (2017), Cell Reports. 20, 11, p. 2547-2555
  • Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells

    Authors: Haimovich G., Ecker C. M., Dunagin M. C., Eggan E., Raj A., Gerst J. E. & Singer R. H. (2017), Proceedings Of The National Academy Of Sciences Of The United States Of America-Physical Sciences. 114, 46, p. E9873-E9882
  • Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death

    Authors: Dasari S. K., Bialik S., Levin-Zaidman S., Levin-Salomon V., Merrill A. H. J., Futerman A. H. & Kimchi A. (2017), Cell Death and Differentiation. 24, p. 1288-1302
  • Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

    Authors: Arce Vargas F., Furness A. J., Solomon I., Joshi K., Mekkaoui L., Lesko M. H., Miranda Rota E., Dahan R., Georgiou A., Sledzinska A., Ben Aissa A., Franz D., Werner Sunderland M., Wong Y. N. S., Henry J. Y., O'Brien T., Nicol D., Challacombe B., Beers S. A. & Spain L. (2017), Immunity. 46, 4, p. 577-586
  • A pyrrole-based natural small molecule mitigates HSP90 expression in MDA-MB-231 cells and inhibits tumor angiogenesis in mice by inactivating HSF-1

    Authors: Rashmi K. C., Atreya H. S., Harsha Raj M., Salimath B. P. & Aparna H. S. (2017), Cell Stress and Chaperones. 22, 5, p. 751-766
  • Recommendations for surveillance for children with leukemia-predisposing conditions

    Authors: Porter C. C., Druley T. E., Erez A., Kuiper R. P., Onel K., Schiffman J. D., Schneider K. W., Scollon S. R., Scott H. S., Strong L. C., Walsh M. F. & Nichols K. E. (2017), Clinical Cancer Research. 23, 11, p. e14-e22
  • RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer

    Authors: Tarcic O., Granit R. Z., Pateras I. S., Masury H., Maly B., Zwang Y., Yarden Y., Gorgoulis V. G., Pikarsky E., Ben-Porath I. & Oren M. (2017), Cell Death and Differentiation. 24, 4, p. 694-704
  • Receptor Protein Tyrosine Phosphatase alpha-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice

    Authors: Stanford S. M., Svensson M. N. D., Sacchetti C., Pilo C. A., Wu D. J., Kiosses W. B., Hellvard A., Bergum B., Muench G. R. A., Elly C., Liu Y., den Hertog J., Elson A., Sap J., Mydel P., Boyle D. L., Corr M., Firestein G. S. & Bottini N. (2016), Arthritis & Rheumatology. 68, 2, p. 359-369
  • Combinatorial treatment with anacardic acid followed by TRAIL augments induction of apoptosis in TRAIL resistant cancer cells by the regulation of p53, MAPK and NFκβ pathways

    Authors: Harsha Raj M., Yashaswini B., Rössler J. & Salimath B. P. (2016), Apoptosis. 21, 5, p. 578-593
  • TMPRSS2-ERG fusion protein regulates insulin-like growth factor-1 receptor (IGF1R) gene expression in prostate cancer: Involvement of transcription factor Sp1

    Authors: Meisel Sharon S., Pozniak Y., Geiger T. & Werner H. (2016), Oncotarget. 7, 32, p. 51375-51392
  • The Paradox of p53: What, how, and why?

  • Co-targeting of Adenosine Signaling Pathways for Immunotherapy: Potentiation by Fc Receptor Engagement

    Authors: Dahan R. & Ravetch J. V. (2016),
  • Measurement of lymphocyte aggregation by flow cytometry-physiological implications in chronic lymphocytic leukemia

    Authors: Dezorella N., Kay S., Baron S., Shapiro M., Porat Z., Deutsch V., Herishanu Y. & Katz B. (2016), Cytometry. Part B, Clinical cytometry. 90, 3, p. 257-266
  • Wnt signaling in cancer stem cells and colon cancer metastasis

    Authors: Basu S., Haase G. & Ben-Ze'ev A. (2016), F1000Research. 5, 699
  • MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

    Authors: Yu J., Lei R., Zhuang X., Li X., Li G., Lev S., Segura M., Zhang X. & Hu G. (2016), Nature Communications. 7, 13884
  • Prolonged insulin treatment sensitizes apoptosis pathways in pancreatic β cells

    Authors: Bucris E., Beck A., Boura-Halfon S., Isaac R., Vinik Y., Rosenzweig T. & Sampson S. R. (2016), Journal of Endocrinology. 230, 3, p. 291-307
  • p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression

    Authors: Drayman N., Ben-nun-Shaul O., Butin-Israeli V., Srivastava R., Rubinstein A. M., Mock C. S. & Elyada E. (2016), Oncotarget. 7, 33, p. 52643-52660
  • Imaging the DNA alkylator melphalan by CEST MRI: An advanced approach to theranostics

    Authors: Ngen E. J., Bar-Shir A., Jablonska A., Liu G., Song X., Ansari R., Bulte J. W., Janowski M., Pearl M., Walczak P. & Gilad A. A. (2016), Molecular Pharmaceutics. 13, 9, p. 3043-3053
  • Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex

    Authors: Chmiest D., Sharma N., Zanin N., Viaris De Lesegno C., Shafaq-Zadah M., Sibut V., Dingli F., Hupé P., Wilmes S., Piehler J., Loew D., Johannes L., Schreiber G. & Lamaze C. (2016), Nature Communications. 7, 13476
  • The Relationship Between Plasma Cytokine Levels and Response to Selective Serotonin Reuptake Inhibitor Treatment in Children and Adolescents with Depression and/or Anxiety Disorders

    Authors: Amitai M., Taler M., Carmel M., Michaelovsky E., Eilat T., Yablonski M., Orpaz N., Chen A., Apter A., Weizman A. & Fennig S. (2016), Journal of Child and Adolescent Psychopharmacology. 26, 8, p. 727-732
  • Production of Osteoclasts for Studying Protein Tyrosine Phosphatase Signaling

  • Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells

    Authors: Kozela E., Juknat A., Gao F., Kaushansky N., Coppola G. & Vogel Z. (2016), Journal of Neuroinflammation. 13, 1, 136
  • NKG2D ligands mediate immunosurveillance of senescent cells

    Authors: Sagiv A., Burton D., Moshayev Z., Vadai E., Wensveen F., Ben-Dor S., Golani O., Polic B. & Krizhanovsky V. (2016), AGING-US. 8, 2, p. 328-344
  • The epigenetic landscape of T cell exhaustion

    Authors: Sen D. R., Kaminski J., Barnitz R. A., Kurachi M., Gerdemann U., Yates K. B., Tsao H., Godec J., LaFleur M. W., Brown F. D., Tonnerre P., Chung R. T., Tully D. C., Allen T. M., Frahm N., Lauer G. M., Wherry E. J., Yosef N. & Haining W. N. (2016), Science. 354, 6316, p. 1165-1169
  • Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

    Authors: Rodgers D. T., Mazagova M., Hampton E. N., Cao Y., Ramadoss N. S., Hardy I. R., Schulman A., Du J., Wang F., Singer O., Ma J., Nunez V., Shen J., Woods A. K., Wright T. M., Schultz P. G., Kim C. H. & Young T. S. (2016), Proceedings of the National Academy of Sciences of the United States of America. 113, 4, p. E459-E468
  • Removing silicone artifacts in diffusion-weighted breast MRI by means of shift-resolved spatiotemporally encoding

    Authors: Solomon E., Nissan N., Schmidt R., Furman-Haran E., Ben-Aharon U. & Frydman L. (2016), Magnetic Resonance in Medicine. 75, 5, p. 2064-2071
  • Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

    Authors: Georgoudaki A. M., Prokopec K. E., Boura V. F., Hellqvist E., Sohn S., Östling J., Dahan R., Harris R. A., Rantalainen M., Klevebring D., Sund M., Brage S. E., Fuxe J., Rolny C., Li F., Ravetch J. V. & Karlsson M. C. (2016), Cell Reports. 15, 9, p. 2000-2011
  • LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer

    Authors: Sas-Chen A., Aure M. R., Leibovich L., Carvalho S., Enuka Y., Korner C., Polycarpou-Schwarz M., Lavi S., Nevo N., Kuznetsov Y., Yuan J., Azuaje F., Ulitsky I., Diederichs S., Wiemann S., Yakhini Z., Kristensen V. N., Borresen-Dale A. & Yarden Y. (2016), EMBO Molecular Medicine. 8, 9, p. 1052-1064
  • The relationship between the nucleolus and cancer: Current evidence and emerging paradigms

    Authors: Orsolic I., Jurada D., Pullen N., Oren M., Eliopoulos A. G. & Volarevic S. (2016), Seminars in Cancer Biology. 37-38, p. 36-50
  • Ellipsoid segmentation model for analyzing light-attenuated 3D confocal image stacks of fluorescent multi-cellular spheroids

    Authors: Barbier M., Jaensch S., Cornelissen F., Vidic S., Gjerde K., De Hoogt R., Graeser R., Gustin E., Chong Y. T., Hickman J., Burbridge M., Verschuren E., Kallioniemi O., Klefström J., Brisken C., Rotter V., Oren M., Brito C., Schalken J. & Jenster G. (2016), PLoS ONE. 11, 6, e0156942
  • Tumor macrophages are pivotal constructors of tumor collagenous matrix

    Authors: Afik R., Zigmond E., Vugman M., Klepfish M., Shimshoni E., Pasmanik-Chor M., Shenoy A., Bassat E., Halpern Z., Geiger T., Sagi I. & Varol C. (2016), Journal of Experimental Medicine. 213, 11, p. 2315-2331
  • Towards the emerging crosstalk: ERBB family and steroid hormones

    Authors: D'Uva G. & Lauriola M. (2016), SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 50, p. 143-152
  • The Hippo pathway, p53 and cholesterol

    Authors: Aylon Y. & Oren M. (2016), Cell cycle (Georgetown, Tex.). 15, 17, p. 2248-2255
  • Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

    Authors: Yosef R., Pilpel N., Tokarsky-Amiel R., Biran A., Ovadya Y., Cohen S., Vadai E., Dassa L., Shahar E., Condiotti R., Ben-Porath I. & Krizhanovsky V. (2016), Nature Communications. 7, 11190
  • Oncogenic mutant p53 gain of function nourishes the vicious cycle of tumor development and cancer stem-cell formation

    Authors: Shetzer Y., Molchadsky A. & Rotter V. (2016), Cold Spring Harbor perspectives in medicine. 6, 10, a026203
  • System-wide Clinical Proteomics of Breast Cancer Reveals Global Remodeling of Tissue Homeostasis

    Authors: Pozniak Y., Balint-Lahat N., Rudolph J. D., Lindskog C., Katzir R., Avivi C., Pontén F., Ruppin E., Barshack I. & Geiger T. (2016), Cell Systems. 2, 3, p. 172-184
  • Prediction of multidimensional drug dose responses based on measurements of drug pairs

    Authors: Zimmer A., Katzir I., Dekel E., Mayo A. E., Alon U., Arcavi I., Challis P., Chambers K. C., Chen T. -., Cowperthwaite P. S., Gal-Yam A., Hosseinzadeh G., Howell D. A., Inserra C., Kankare E., Magnier E. A., Maguire K., Mazzali P. A., McCully C., Milisavljevic D., Smith K. W., Taubenberger S., Valenti S., Wainscoat R. J., Yaron O. & Young D. R. (2016), Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. 10442-10447
  • Nonthermal ablation by using intravascular oxygen radical generation with WST11: Dynamic tissue effects and implications for focal therapy

    Authors: Kimm S., Tarin T., Monette S., Srimathveeravalli G., Gerber D., Durack J., Solomon S., Scardino P., Scherz A. & Coleman J. (2016), Radiology. 281, 1, p. 109-118
  • FXYD5 Protein Has a Pro-inflammatory Role in Epithelial Cells

    Authors: Lubarski-Gotliv I., Asher C., Dada L. A. & Garty H. (2016), Journal of Biological Chemistry. 291, 21, p. 11072-11082, 27006401
  • Analysis of subcellular RNA fractions revealed a transcription- independent effect of tumor necrosis factor alpha on splicing, mediated by Spt5

    Authors: Diamant G., Eisenbaum T., Leshkowitz D. & Dikstein R. (2016), Molecular and Cellular Biology. 36, 9, p. 1342-1353
  • Adipose-induced retroperitoneal soft tissue sarcoma tumorigenesis: A potential crosstalk between sarcoma and fat cells

    Authors: Loewenstein S., Lubezky N., Nizri E., Zemel M., Levin Y., Savidor A., Sher O., Klausner J. & Lahat G. (2016), Molecular Cancer Research. 14, 12, p. 1254-1265
  • The cybernetics of TNF: Old views and newer ones

  • mRNA-based dendritic cell immunization improves survival in ret transgenic mouse melanoma model

    Authors: Sharbi-Yunger A., Grees M., Tzehoval E., Utikal J., Umansky V. & Eisenbach L. (2016), OncoImmunology. 5, 6, e1160183
  • Mutational and network level mechanisms underlying resistance to anti-cancer kinase inhibitors

    Authors: Mancini M. & Yarden Y. (2016), SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 50, p. 164-176
  • Interfering with the Dimerization of the ERBB Receptors by Transmembrane Domain-Derived Peptides Inhibits Tumorigenic Growth in Vitro and in Vivo

    Authors: Bublil E. M., Cohen T., Arnusch C. J., Peleg A., Pines G., Lavi S. & Yarden Y. (2016), Biochemistry. 55, 39, p. 5520-5530
  • Emerging Role of Dysadherin in Metastasis

  • The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry

    Authors: Simerzin A., Zorde-Khvalevsky E., Rivkin M., Adar R., Zucman-Rossi J., Couchy G., Roskams T., Govaere O., Oren M., Giladi H. & Galun E. (2016), Hepatology. 64, 5, p. 1623-1636
  • Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells

    Authors: Grespi F., Landré V., Molchadsky A., Di Daniele N., Marsella L. T., Melino G. & Rotter V. (2016), Cell Death & Disease. 7, 12, e2567
  • Identification of a Functional Risk Variant for Pemphigus Vulgaris in the ST18 Gene

    Authors: Vodo D., Sarig O., Geller S., Ben-Asher E., Olender T., Bochner R., Goldberg I., Nosgorodsky J., Alkelai A., Tatarskyy P., Peled A., Baum S., Barzilai A., Ibrahim S. M., Zillikens D., Lancet D. & Sprecher E. (2016), PLoS Genetics. 12, 5, e1006008
  • The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation

    Authors: Aylon Y., Gershoni A., Rotkopf R., Biton I. E., Porat Z., Koh A. P., Sun X., Lee Y., Fiel M., Hoshida Y., Friedman S. L., Johnson R. L. & Oren M. (2016), GENES & DEVELOPMENT. 30, 7, p. 786-797
  • ESMO/ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016

    Authors: Dittrich C., Kosty M., Jezdic S., Pyle D., Berardi R., Bergh J., El-Saghir N., Lotz J. P., Österlund P., Pavlidis N., Purkalne G., Awada A., Banerjee S., Bhatia S., Bogaerts J., Buckner J., Cardoso F., Casali P., Chu E., Close J. L., Coiffier B., Connolly R., Coupland S., De Petris L., De Santis M., De Vries E. G., Dizon D. S., Duff J., Duska L. R., Eniu A., Ernstoff M., Felip E., Fey M. F., Gilbert J., Girard N., Glaudemans A. W., Gopalan P. K., Grothey A., Hahn S. M., Hanna D., Herold C., Herrstedt J., Homicsko K., Jones D. V., Jost L., Keilholz U., Khan S., Kiss A., Köhne C. H., Kunstfeld R., Lenz H. J., Lichtman S., Licitra L., Lion T., Litière S., Liu L., Loehrer P. J., Markham M. J., Markman B., Mayerhoefer M., Meran J. G., Michielin O., Moser E. C., Mountzios G., Moynihan T., Nielsen T., Ohe Y., Öberg K., Palumbo A., Peccatori F. A., Pfeilstöcker M., Raut C., Remick S. C., Robson M., Rutkowski P., Salgado R., Schapira L., Schernhammer E., Schlumberger M., Schmoll H. J., Schnipper L., Sessa C., Shapiro C. L., Steele J., Sternberg C. N., Stiefel F., Strasser F., Stupp R., Sullivan R., Tabernero J., Travado L., Verheij M., Voest E., Vokes E., Von Roenn J., Weber J. S., Wildiers H. & Yarden Y. (2016), ESMO Open. 1, 5, e000097
  • P53 mutations promote proteasomal activity

    Authors: Oren M. & Kotler E. (2016),
  • The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila

    Authors: Koerver L., Melzer J., Roca E. A., Teichert D., Glatter T., Arama E. & Broemer M. (2016), Cell Death Differ. 23, 12, p. 2019-2030
  • Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape

    Authors: Li Q., Wennborg A., Aurell E., Dekel E., Zou J., Xu Y., Huang S. -. J. & Ernberg I. (2016), Proceedings of the National Academy of Sciences of the United States of America. 113, 10, p. 2672-2677
  • Non-alcoholic fatty liver and the gut microbiota

    Authors: Bashiardes S., Shapiro H., Rozin S., Shibolet O. & Elinav E. (2016), Molecular Metabolism. 5, 9, p. 782-794
  • Widespread parainflammation in human cancer

    Authors: Aran D., Lasry A., Zinger A., Biton M., Pikarsky E., Hellman A., Butte A. J. & Ben-Neriah Y. (2016), Genome Biology. 17, 1, 145
  • DTIE, a novel core promoter element that directs start site selection in TATA-less genes

    Authors: Marbach-Bar N., Bahat A., Ashkenazi S., Golan Mashiach M. M., Haimov O., Wu S., Chiang C., Puzio-Kuter A., Hirshfield K., Levine A. & Dikstein R. (2016), Nucleic Acids Research. 44, 3, p. 1080-1094
  • ADAM17 substrate release in proximal tubule drives kidney fibrosis

    Authors: Kefaloyianni E., Muthu M. L., Kaeppler J., Sun X., Sabbisetti V., Chalaris A., Rose-John S., Wong E., Sagi I., Waikar S. S., Rennke H., Humphreys B. D., Bonventre J. V. & Herrlich A. (2016), Africa Insight. 1, 13, e87023
  • Estrogen receptor-targeted contrast agents for molecular magnetic resonance imaging of breast cancer hormonal status

    Authors: Pais A. & Degani H. (2016), Frontiers in Oncology. 6, APR, 100
  • A metabolic link between the urea cycle and cancer cell proliferation

    Authors: Nagamani S. C. S. & Erez A. (2016), Molecular & cellular oncology. 3, 2, 1127314
  • The dynamic subcellular localization of ERK: Mechanisms of translocation and role in various organelles

    Authors: Wainstein E. & Seger R. (2016), Current Opinion in Cell Biology. 39, p. 15-20
  • PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

    Authors: Baruch K., Deczkowska A., Rosenzweig N., Tsitsou-Kampeli A., Sharif A. M., Matcovitch-Natan O., Kertser A., David E., Amit I. & Schwartz M. (2016), Nature Medicine. 22, 2, p. 135-137
  • Tumor cell invasion can be blocked by modulators of collagen fibril alignment that control assembly of the extracellular matrix

    Authors: Grossman M., Ben-Chetrit N., Zhuravlev A., Afik R., Bassat E., Solomonov I., Yarden Y. & Sagi I. (2016), Cancer Res.. 76, 14, 052206
  • Treatment Effects of WST11 Vascular Targeted Photodynamic Therapy for Urothelial Cell Carcinoma in Swine

    Authors: Murray K. S., Winter A. G., Corradi R. B., LaRosa S., Jebiwott S., Somma A., Takaki H., Srimathveeravalli G., Lepherd M., Monette S., Kim K., Scherz A. & Coleman J. A. (2016), Journal of Urology. 196, 1, p. 236-243
  • Tumor Necrosis Factor Alpha (TNFalpha)

    Authors: Wallach D. & Kovalenko A. (2016), Compendium of Inflammatory Diseases.
  • Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma

    Authors: Grossman I., Ilani T., Fleishman S. & Fass D. (2016), Protein engineering, design & selection : PEDS. 29, 4, p. 135-147
  • Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation

    Authors: Charni M., Molchadsky A., Goldstein I., Solomon H., Tal P., Goldfinger N., Yang P., Porat Z., Lozano G. & Rotter V. (2016), Cell Death and Differentiation. 23, 3, p. 509-520
  • Parkinson disease (PARK) genes are somatically mutated in cutaneous melanoma

    Authors: Inzelberg R., Samuels Y., Azizi E., Qutob N., Inzelberg L., Domany E., Schechtman E. & Friedman E. (2016), Neurology: Genetics. 2, 3, e70
  • The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells

    Authors: Revach O. Y., Winograd-Katz S. E., Samuels Y. & Geiger B. (2016), Experimental Cell Research. 343, 1, p. 82-88
  • The evolution of T-cell depletion in haploidentical stem-cell transplantation

    Authors: Or Geva N. & Reisner Y. (2016), British Journal of Haematology. 172, 5, p. 667-684
  • Microglia Replenished OHSC: A Culture System to Study In Vivo Like Adult Microglia

    Authors: Masuch A., van der Pijl d. P. R., Fuener L., Wolf Y., Eggen B., Boddeke E., Biber K., Dalimot J., Bergmueller E., Jung S., Voortman S., Winterhager E., Brandau S., Garbi N., Kurrer M., Eriksson U., Gunzer M. & Hasenberg M. (2016), GLIA. 64, 8, p. 1285-1297
  • Breast MRI: Malignant Cystosarcoma Phyllodes Tumor Exhibits Unique Anisotropic Diffusion

    Authors: Nissan N., Ben-Aharon U. & Yosepovich A. (2016), Israel Medical Association Journal. 18, p. 368-369
  • Optimization of DCE-MRI protocol for the assessment of patients with brain tumors

    Authors: Artzi M., Liberman G., Nadav G., Blumenthal D. T., Bokstein F., Aizenstein O. & Bashat D. B. (2016), Magnetic Resonance Imaging. 34, 9, p. 1242
  • Immunotherapy of cancer: From monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR Review 18

    Authors: Carvalho S., Levi-Schaffer F., Sela M. & Yarden Y. (2016), British Journal of Pharmacology. 173, 9, p. 1407-1424
  • Post-translational modification profiling - A novel tool for mapping the protein modification landscape in cancer

    Authors: Eisenberg-Lerner A., Ciechanover A. & Merbl Y. (2016), Experimental Biology and Medicine. 241, 14, p. 1475-1482
  • An antibody to amphiregulin, an abundant growth factor in patients' fluids, inhibits ovarian tumors

    Authors: Carvalho S., Lindzen M., Lauriola M., Shirazi N., Sinha S., Abdul-Hai A., Levanon K., Korach J., Barshack I., Cohen Y., Onn A., Mills G. & Yarden Y. (2016), Oncogene. 35, 4, p. 438-447
  • Adjuvant Autologous Melanoma Vaccine for Macroscopic Stage III Disease: Survival, Biomarkers, and Improved Response to CTLA-4 Blockade

    Authors: Lotem M., Merims S., Frank S., Hamburger T., Nissan A., Kadouri L., Cohen J., Straussman R., Eisenberg G., Frankenburg S., Carmon E., Alaiyan B., Shneibaum S., Ayyildiz Z. O., Isbilen M., Senses K. M., Ron I., Steinberg H., Smith Y., Shiloni E., Gure A. O. & Peretz T. (2016), Journal of Immunology Research. 2016, 8121985
  • Genetic and pharmacological modulation of Akt1 for improving ovarian graft revascularization in a mouse model

    Authors: Cohen Y., Dafni H., Avni R., Fellus L., Bochner F., Rotkopf R., Raz T., Benjamin L. E., Walsh K. & Neeman M. (2016), Biology of Reproduction. 94, 1, 14
  • Extracellular matrix and tissue regeneration

    Authors: Mackiewicz Z., Konttinen Y. T., Kaivosoja E., Stegajev V., Wagner H. D., Levón J. & Tiainen V. M. (2016), Regenerative Medicine - from Protocol to Patient. Steinhoff G. (eds.). 3 ed. p. 1-55
  • Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries

    Authors: Karniely S., Weekes M. P., Antrobus R., Rorbach J., van Haute H. L., Umrania Y., Smith D. L., Stanton R. J., Minczuk M., Lehner P. J. & Sinclair J. H. (2016), mBio. 7, 2, e00029-16
  • Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours

    Authors: Golias T., Papandreou I., Sun R., Kumar B., Brown N. V., Swanson B. J., Pai R., Jaitin D., Le Q. T., Teknos T. N. & Denko N. C. (2016), Scientific Reports. 6, 31146
  • Harnessing the natural inhibitory domain to control TNF alpha Converting Enzyme (TACE) activity in vivo

    Authors: Wong E., Cohen T., Romi E., Levin M., Peleg Y., Arad U., Yaron A., Milla M. E. & Sagi I. (2016), Scientific Reports. 6, 35598
  • Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms

    Authors: Zhang L., Cheng Q., Zhang L., Wang Y., Merrill G. F., Ilani T., Fass D., Arner E. S. J. & Zhang J. (2016), Free Radical Biology and Medicine. 99, p. 426-435
  • RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

    Authors: Tarcic O., Pateras I. S., Cooks T., Shema E., Kanterman J., Ashkenazi H., Boocholez H., Hubert A., Rotkopf R., Baniyash M., Pikarsky E., Gorgoulis V. G. & Oren M. (2016), Cell Reports. 14, 6, p. 1462-1476
  • Targeting mutant p53 for cancer therapy

    Authors: Oren M., Tal P. & Rotter V. (2016), AGING-US. 8, 6, p. 1159-1160
  • Inferring Cell-State Transition Dynamics from Lineage Trees and Endpoint Single-Cell Measurements

    Authors: Hormoz S., Singer Z. S., Linton J. M., Antebi Y. E., Shraiman B. I. & Elowitz M. B. (2016), Cell Systems. 3, 5, p. 419-433.e8
  • Emerging anti-cancer antibodies and combination therapies targeting HER3/ERBB3

    Authors: Gaborit N., Lindzen M. & Yarden Y. (2016), Human Vaccines & Immunotherapeutics. 12, 3, p. 576-592
  • Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

    Authors: Chou T. F., Chuang Y. T., Hsieh W. C., Chang P. Y., Liu H. Y., Mo S. T., Hsu T. S., Miaw S. C., Chen R. H., Kimchi A. & Lai M. Z. (2016), Nature Communications. 7, 11904
  • Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast

    Authors: Ragg R., Schilmann A. M., Korschelt K., Wieseotte C., Kluenker M., Viel M., Voelker L., Preiss S., Herzberger J., Frey H., Heinze K., Bluemler P., Tahir M. N., Natalio F. & Tremel W. (2016), Journal of Materials Chemistry B. 4, 46, p. 7423-7428
  • Genetic manipulation of iron biomineralization enhances MR relaxivity in a ferritin-M6A chimeric complex

    Authors: Radoul M., Lewin L., Cohen B., Oren R., Popov S., Davidov G., Vandsburger M. H., Harmelin A., Bitton R., Greneche J., Neeman M. & Zarivach R. (2016), Scientific Reports. 6, 26550
  • Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement

    Authors: Dahan R., Barnhart B. C., Li F., Yamniuk A. P., Korman A. J. & Ravetch J. V. (2016), Cancer Cell. 29, 6, p. 820-831
  • Androgen deprivation therapy potentiates the efficacy of vascular targeted photodynamic therapy of prostate cancer xenografts

    Authors: Kim K., Watson P. A., Jebiwott S., Somma A. J., La Rosa R. S. P., Mehta D., Murray K. S., Lilja H., Ulmert D., Scherz A. & Coleman J. A. (2016), Cancer Research. 76, 2016
  • Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

    Authors: Wattananit S., Tornero D., Graubardt N., Memanishvili T., Monni E., Tatarishvili J., Miskinyte G., Ge R., Ahlenius H., Lindvall O., Schwartz M. & Kokaia Z. (2016), Journal of Neuroscience. 36, 15, p. 4182-4195
  • Ramucirumab: Boon or bane

  • Fibroblast recruitment as a tool for ovarian cancer detection and targeted therapy

    Authors: Oren R., Addadi Y., Haziza L. N., Dafni H., Rotkopf R., Meir G., Fishman A. & Neeman M. (2016), International Journal of Cancer. 139, 8, p. 1788-1798
  • A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors

    Authors: Gelfo V., Rodia M. T., Pucci M., Dall'Ora M., Santi S., Solmi R., Roth L., Lindzen M., Bonafe M., Bertotti A., Caramelli E., Lollini P., Trusolino L., Yarden Y., D'Uva G. & Lauriola M. (2016), Oncotarget. 7, 44, p. 72167-72183
  • A novel allosteric mechanism of NF-κB dimerization and DNA binding targeted by an anti-inflammatory drug

    Authors: Ashkenazi S., Plotnikov A., Bahat A., Ben-Zeev E., Warszawski S. & Dikstein R. (2016), Molecular and Cellular Biology. 36, 8, p. 1237-1247
  • Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor

    Authors: Aghajanian H., Cho Y. K., Manderfield L. J., Herling M. R., Gupta M., Ho V. C., Li L., Degenhardt K., Aharonov A., Tzahor E. & Epstein J. A. (2016), Nature Communications. 7, 12038
  • MicroRNAs: Non-coding fine tuners of receptor tyrosine kinase signalling in cancer

    Authors: Donzelli S., Cioce M., Muti P., Strano S., Yarden Y. & Blandino G. (2016), SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 50, p. 133-142
  • A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

    Authors: Notta F., Chan-Seng-Yue M., Lemire M., Li Y., Wilson G. W., Connor A. A., Denroche R. E., Liang S. B., Brown A. M., Kim J. C., Wang T., Simpson J. T., Beck T., Borgida A., Buchner N., Chadwick D., Hafezi-Bakhtiari S., Dick J. E., Heisler L., Hollingsworth M. A., Ibrahimov E., Jang G. H., Johns J., Jorgensen L. G., Law C., Ludkovski O., Lungu I., Ng K., Pasternack D., Petersen G. M., Shlush L. I., Timms L., Tsao M. S., Wilson J. M., Yung C. K., Zogopoulos G., Bartlett J. M., Alexandrov L. B., Real F. X., Cleary S. P., Roehrl M. H., McPherson J. D., Stein L. D., Hudson T. J., Campbell P. J. & Gallinger S. (2016), Nature. 538, 7625, p. 378-382
  • A network-based analysis of colon cancer Splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1

    Authors: Hollander D., Donyo M., Atias N., Mekahel K., Melamed Z., Yannai S., Lev-Maor G., Shilo A., Schwartz S., Barshack I., Sharan R. & Ast G. (2016), Genome Research. 26, 4, p. 541-553
  • Use of HLA peptidomics and whole exome sequencing to identify human immunogenic neo-antigens

    Authors: Kalaora S., Barnea E., Merhavi-Shoham E., Qutob N., Teer J. K., Shimony N., Schachter J., Rosenberg S. A., Besser M. J., Admon A. & Samuels Y. (2016), Oncotarget. 7, 5, p. 5110-5117
  • The Anticancer Activity of Organotelluranes: Potential Role in Integrin Inactivation

    Authors: Silberman A., Kalechman Y., Hirsch S., Erlich Z., Sredni B. & Albeck A. (2016), ChemBioChem. 17, 10, p. 918-927
  • Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters

    Authors: Darash-Yahana M., Pozniak Y., Lu M., Sohn Y., Karmi O., Tamir S., Bai F., Song L., Jennings P. A., Pikarsky E., Geiger T., Onuchic J. N., Mittler R. & Nechushtai R. (2016), Proceedings of the National Academy of Sciences of the United States of America. 113, 39, p. 10890-10895
  • Can diffusion tensor anisotropy indices assist in breast cancer detection?

    Authors: Furman-Haran E., Grobgeld D., Nissan N., Shapiro-Feinberg M. & Degani H. (2016), Journal of Magnetic Resonance Imaging. 44, 6, p. 1624-1632
  • Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

    Authors: Tal P., Eizenberger S., Cohen E., Goldfinger N., Pietrokovski S., Oren M. & Rotter V. (2016), Oncotarget. 7, 11, p. 11817-11837
  • Proteomic maps of breast cancer subtypes

    Authors: Tyanova S., Albrechtsen R., Kronqvist P., Cox J., Mann M. & Geiger T. (2016), Nature Communications. 7, 10259
  • Therapeutic Potential of T Cell Chimeric Antigen Receptors (CARs) in Cancer Treatment: Counteracting Off-Tumor Toxicities for Safe CAR T Cell Therapy

    Authors: Gross G. & Eshhar Z. (2016), Annual Review of Pharmacology and Toxicology. 56, p. 59-+
  • Novel therapeutic compound tuftsin-phosphorylcholine attenuates collagen-induced arthritis

    Authors: Bashi T., Shovman O., Fridkin M., Volkov A., Barshack I., Blank M. & Shoenfeld Y. (2016), Clinical and Experimental Immunology. 184, 1, p. 19-28
  • Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease

    Authors: Yaeger R., Shah M. A., Miller V. A., Kelsen J. R., Wang K., Heins Z. J., Ross J. S., He Y., Sanford E., Yantiss R. K., Balasubramanian S., Stephens P. J., Schultz N., Oren M., Tang L. & Kelsen D. (2016), Gastroenterology. 151, 2, p. 278-287.e6
  • Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

    Authors: Hao Y., Samuels Y., Li Q., Krokowski D., Guan B., Wang C., Jin Z., Dong B., Cao B., Feng X., Xiang M., Xu C., Fink S., Meropol N. J., Xu Y., Conlon R. A., Markowitz S., Kinzler K. W., Velculescu V. E., Brunengraber H., Willis J. E., LaFramboise T., Hatzoglou M., Zhang G., Vogelstein B. & Wang Z. (2016), Nature Communications. 7, 11971
  • Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

    Authors: Stock K., Estrada M. F., Vidic S., Gjerde K., Rudisch A., Santo V. E., Barbier M., Blom S., Arundkar S. C., Selvam I., Osswald A., Stein Y., Gruenewald S., Brito C., Van Weerden W., Rotter V., Boghaert E., Oren M., Sommergruber W., Chong Y., De Hoogt R. & Graeser R. (2016), Scientific Reports. 6, 28951
  • The combination of trastuzumab and pertuzumab administered at approved doses may delay development of trastuzumab resistance by additively enhancing antibody-dependent cell-mediated cytotoxicity

    Authors: Toth G., Szoor A., Simon L., Yarden Y., Szollosi J. & Vereb G. (2016), mAbs. 8, 7, p. 1361-1370
  • The Proteome of Primary Prostate Cancer

    Authors: Iglesias-Gato D., Wikström P., Tyanova S., Lavallee C., Thysell E., Carlsson J., Hägglöf C., Cox J., Andrén O., Stattin P., Egevad L., Widmark A., Bjartell A., Collins C. C., Bergh A., Geiger T., Mann M. & Flores-Morales A. (2016), European Urology. 69, 5, p. 942-952
  • Role of the microbiome in non-gastrointestinal cancers

    Authors: Pevsner-Fischer M., Tuganbaev T., Meijer M., Zhang S., Zeng Z., Chen M. & Elinav E. (2016), World Journal of Clinical Oncology. 7, 2, p. 200-213
  • Differentiation between treatment-related changes and progressive disease in patients with high grade brain tumors using support vector machine classification based on DCE MRI

    Authors: Artzi M., Liberman G., Nadav G., Blumenthal D. T., Bokstein F., Aizenstein O. & Ben Bashat D. (2016), Journal of Neuro-Oncology. 127, 3, p. 515-524
  • Matrix metalloproteinase protein inhibitors: highlighting a new beginning for metalloproteinases in medicine

    Authors: Mohan V., Talmi-Frank D., Arkadash V., Papo N. & Sagi I. (2016), Metalloproteinases In Medicine. 3, p. 31-47
  • Zooming in on selectins in cancer

    Authors: Kedmi R. & Peer D. (2016),
  • Vascular-Targeted Photodynamic Therapy in Prostate Cancer: From Bench to Clinic

    Authors: Scherz A., Salomon Y., Lindner U. & Coleman J. (2016), PHOTODYNAMIC MEDICINE: FROM BENCH TO CLINIC. p. 461-480
  • HER2-Targeted Polyinosine/Polycytosine Therapy Inhibits Tumor Growth and Modulates the Tumor Immune Microenvironment

    Authors: Zigler M., Shir A., Joubran S., Sagalov A., Edinger N., Lau J., Yu S., Mizraji G., Globerson Levin A., Sliwkowski M. X. & Levitzki A. (2016), Cancer Immunology Research. 4, 8, p. 688-697
  • Pathology in Practice

    Authors: Tirosh-Levy S., Brener O., Aloisio F., Tatz A. J. & Kelmer G. (2016), JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION. 248, 10, p. 1131-1133
  • The tumor as an organ: comprehensive spatial and temporal modeling of the tumor and its microenvironment.

    Authors: Bloch N. & Harel D. (2016), BMC Bioinformatics. 17, 1, 317
  • Parkin Somatic Mutations Link Melanoma and Parkinson's Disease

    Authors: Levin L., Srour S., Gartner J., Kapitansky O., Qutob N., Dror S., Golan T., Dayan R., Brener R., Ziv T., Khaled M., Schueler-Furman O., Samuels Y. & Levy C. (2016), Journal of Genetics and Genomics. 43, 6, p. 369-379
  • Tumor evolution inferred by patterns of microRNA expression through the course of disease, therapy, and recurrence in breast cancer

    Authors: Dadiani M., Ben-Moshe N. B., Paluch-Shimon S., Perry G., Balint N., Marin I., Pavlovski A., Morzaev D., Kahana-Edwin S., Yosepovich A., Gal-Yam E. N., Berger R., Barshack I., Domany E. & Kaufman B. (2016), Clinical Cancer Research. 22, 14, p. 3651-3662
  • FXYD5: Na(+)/K(+)-ATPase Regulator in Health and Disease.

  • Cellular heterogeneity mediates inherent sensitivity-specificity tradeoff in cancer targeting by Synthetic circuits

    Authors: Morel M., Shtrahman R., Rotter V., Nissim L. & Bar-Ziv R. H. (2016), Proceedings of the National Academy of Sciences of the United States of America. 113, 29, p. 8133-8138
  • A non-aggressive, highly efficient, enzymatic method for dissociation of human brain-tumors and brain-tissues to viable single-cells

    Authors: Volovitz I., Shapira N., Ezer H., Gafni A., Lustgarten M., Alter T., Ben-Horin I., Barzilai O., Shahar T., Kanner A., Fried I., Veshchev I., Grossman R. & Ram Z. (2016), BMC Neuroscience. 17, 30
  • Conjugation of methotrexate-amino derivatives to macromolecules through carboxylate moieties is superior over conventional linkage to amino residues: Chemical, cell-free and in vitro characterizations

    Authors: Cooper I., Fridkin M. & Shechter Y. (2016), PLoS ONE. 11, 7, e0158352
  • Bortezomib-induced pro-inflammatory macrophages as a potential factor limiting anti-tumour efficacy

    Authors: Beyar-Katz O., Magidey K., Ben-Tsedek N., Alishekevitz D., Timaner M., Miller V., Lindzen M., Yarden Y., Avivi I. & Shaked Y. (2016), Journal of Pathology. 239, 3, p. 262-273
  • Axonal Degeneration Is Regulated by a Transcriptional Program that Coordinates Expression of Pro- and Anti-degenerative Factors

    Authors: Yaron A., Maor-Nof M., Romi E., Shalom H. S., Ulisse V., Raanan C., Nof A., Leshkowitz D. & Lang R. (2016), Neuron. 92, 5, p. 991-1006
  • Increased number of volatile organic compounds over malignant glottic lesions

    Authors: Shoffel-Havakuk H., Frumin I., Lahav Y., Haviv L., Sobel N. & Halperin D. (2016), The Laryngoscope. 126, 7, p. 1606-1611
  • An essential role for UTX in resolution and activation of bivalent promoters

    Authors: Dhar S. S., Lee S., Chen K., Zhu G., Oh W., Allton K., Gafni O., Kim Y. Z., Tomoiga A. S., Barton M. C., Hanna J. H., Wang Z., Li W. & Lee M. G. (2016), Nucleic Acids Research. 44, 8, p. 3659-3674
  • SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course

    Authors: Dezorella N., Katz B., Shapiro M., Polliack A., Perry C. & Herishanu Y. (2016), Haematologica. 101, 12, p. 1553-1562
  • Tuning the proteasome to brighten the end of the journey

    Authors: Mayor T., Sharon M. & Glickman M. H. (2016), American Journal Of Physiology-Cell Physiology. 311, 5, p. C793-C804
  • Erratum to: Phosphoproteomic analysis reveals Smarcb1 dependent EGFR signaling in Malignant Rhabdoid tumor cells

    Authors: Darr J., Klochendler A., Isaac S., Geiger T. & Eden A. (2016), Molecular Cancer. 15, 1, p. 14-14
  • Multimodal Correlative Preclinical Whole Body Imaging and Segmentation

    Authors: Akselrod-Ballin A., Dafni H., Addadi Y., Biton I., Avni R., Brenner Y. & Neeman M. (2016), Scientific Reports. 6, 27940
  • The Wnt target gene L1 in colon cancer invasion and metastasis

    Authors: Haase G., Gavert N., Brabletz T. & Ben-Ze'ev A. (2016), Cancers. 8, 5, 27187476
  • Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity

    Authors: Kohnz R. A., Roberts L. S., DeTomaso D., Bideyan L., Yan P., Bandyopadhyay S., Goga A., Yosef N. & Nomura D. K. (2016), ACS Chemical Biology. 11, 8, p. 2131-2139
  • The EGFR-HER2 module: A stem cell approach to understanding a prime target and driver of solid tumors

    Authors: Schneider M. R. & Yarden Y. (2016), Oncogene. 35, 23, p. 2949-2960
  • Improved Doxorubicin Encapsulation and Pharmacokinetics of Ferritin-Fusion Protein Nanocarriers Bearing Proline, Serine, and Alanine Elements

    Authors: Falvo E., Tremante E., Arcovito A., Papi M., Elad N., Boffi A., Morea V., Conti G., Toffoli G., Fracasso G., Giacomini P. & Ceci P. (2016), Biomacromolecules. 17, 2, p. 514-522
  • The ERK cascade inhibitors: Towards overcoming resistance

    Authors: Maik-Rachline G. & Seger R. (2016), Drug Resistance Updates. 25, p. 1-12
  • Inhibition of MMP-9 by green tea catechins and prediction of their interaction by molecular docking analysis

    Authors: Sarkar J., Nandy S., Chowdhury A., Chakraborti T. & Chakraborti S. (2016), BIOMEDICINE & PHARMACOTHERAPY. 84, p. 340-347
  • Therapy Related Acute Myeloid Leukemia with t(8;16) Mimicking Acute Promyelocytic Leukemia

    Authors: Chharchhodawala T., Gajendra S., Tiwari P., Gogia A. & Gupta R. (2016), Indian Journal of Hematology and Blood Transfusion. 32, p. 20-22
  • Chronic centrosome amplification without tumorigenesis

    Authors: Vitre B., Holland A. J., Kulukian A., Shoshani O., Hirai M., Wang Y., Maldonado M., Cho T., Boubaker J., Swing D. A., Tessarollo L., Evans S. M., Fuchs E. & Cleveland D. W. (2015), Proceedings of the National Academy of Sciences of the United States of America. 112, 46, p. E6321-E6330
  • A statistical framework to model the meeting-in-the-middle principle using metabolomic data: application to hepatocellular carcinoma in the EPIC study

    Authors: Assi N., Fages A., Vineis P., Chadeau-Hyam M., Stepien M., Duarte-Salles T., Byrnes G., Boumaza H., Knueppel S., Kuehn T., Palli D., Bamia C., Boshuizen H., Bonet C., Overvad K., Johansson M., Travis R., Gunter M. J., Lund E., Dossus L., Elena-Herrmann B., Riboli E., Jenab M., Viallon V. & Ferrari P. (2015), Mutagenesis. 30, 6, p. 743-753
  • Examination of HER3 targeting in cancer using monoclonal antibodies

    Authors: Gaborit N., Abdul-Hai A., Mancini M., Lindzen M., Lavi S., Leitner O., Mounier L., Chentouf M., Dunoyer S., Ghosh M., Larbouret C., Chardes T., Bazin H., Pelegrine A., Sela M. & Yarden Y. (2015), Proceedings of the National Academy of Sciences of the United States of America. 112, 3, p. 839-844
  • Heparanase of murine effector lymphocytes and neutrophils is not required for their diapedesis into sites of inflammation

    Authors: Stoler-Barak L., Petrovich E., Aychek T., Gurevich I., Tal O., Hatzav M., Ilan N., Feigelson S., Shakhar G., Vlodavsky I. & Alon R. (2015), FASEB Journal. 29, 5, p. 2010-2021
  • Preleukemia: The normal side of cancer

    Authors: Shlush L. I. & Minden M. D. (2015), Current Opinion in Hematology. 22, 2, p. 77-84
  • The tissue specific nature of mesenchymal stem/stromal cells: gaining better understanding for improved clinical outcomes

    Authors: Shoshani O., Zipori D. & Shani N. (2015), RNA & disease. 2, Supplement 1, e780
  • AML evolution from preleukemia to leukemia and relapse

    Authors: Shlush L. I. & Mitchell A. (2015), Best Practice and Research: Clinical Haematology. 28, 2-3, p. 81-89
  • The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity

    Authors: Herzog G., Shmueli M. D., Levy L., Engel L., Gazit E., Klärner F. G., Schrader T., Bitan G. & Segal D. (2015), Biochemistry. 54, 24, p. 3729-3738
  • Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth

    Authors: Harel S., Ben-Moshe N., Aylon Y., Bublik D., Moskovits N., Toperoff G., Azaiza D., Biagoni F., Fuchs G., Wilder S., Hellman A., Blandino G., Domany E. & Oren M. (2015), Cell Death and Differentiation. 22, p. 1328-1340
  • Artificial signal transduction therapy: A futuristic approach to disease treatment

    Authors: Peri Naor R., Motiei L. & Margulies D. (2015), Future Medicinal Chemistry. 7, 16, p. 2091-2093
  • FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis

    Authors: Dahan R., Sega E., Engelhardt J., Selby M., Korman A. J. & Ravetch J. V. (2015), Cancer Cell. 28, 3, p. 285-295
  • In the hunt for therapeutic targets: Mimicking the growth, metastasis, and stromal associations of early-stage lung cancer using a novel orthotopic animal model

    Authors: Weiss I. D., Ella E., Dominsky O., Smith Y., Abraham M., Wald H., Shlomai Z., Zamir G., Feigelson S. W., Shezen E., Bar-Shai A., Alon R., Izhar U., Peled A., Shapira O. M. & Wald O. (2015), Journal of Thoracic Oncology. 10, 1, p. 46-58
  • The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an Amyloid-β precursor protein-dependent mechanism

    Authors: Vinograd-Byk H., Sapir T., Cantarero L., Lazo P. A., Zeligson S., Lev D., Lerman-Sagie T., Renbaum P., Reiner O. & Levy-Lahad E. (2015), Journal of Neuroscience. 35, 3, p. 936-942
  • An interactive tool for animating biology, and its use in spatial and temporal modeling of a cancerous tumor and its microenvironment

    Authors: Bloch N., Weiss G., Szekely S. & Harel D. (2015), PLoS ONE. 10, 7, e0133484
  • Phosphorylcholine-tuftsin compound prevents development of dextransulfate-sodium-salt induced murine colitis: Implications for the treatment of human inflammatory bowel disease

    Authors: Shor D. B., Bashi T., Lachnish J., Fridkin M., Bizzaro G., Barshak I., Blank M. & Shoenfeld Y. (2015), Journal of Autoimmunity. 56, p. 111-117
  • Perspective: Consider removing inherited from definitions of pesticide resistance

  • Erratum: A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism (vol 24, pg 242, 2013)

    Authors: Pribluda A., Elyada E., Wiener Z., Hamza H., Goldstein R. E., Biton M., Burstain I., Morgenstern Y., Brachya G., Billauer H., Biton S., Snir-Alkalay I., Vucic D., Schlereth K., Mernberger M., Stiewe T., Oren M., Alitalo K., Pikarsky E. & Ben-Neriah Y. (2015),
  • The role of donor-derived veto cells in nonmyeloablative haploidentical HSCT

    Authors: Or Geva N. & Reisner Y. (2015), Bone Marrow Transplantation. 50, p. S14-S20
  • Development of APE1 enzymatic DNA repair assays: Low APE1 activity is associated with increase lung cancer risk

    Authors: Sevilya Z., Leitner Dagan Y., Pinchev M., Kremer R., Elinger D., Lejbkowicz F., Rennert H. S., Freedman L. S., Rennert G., Paz-Elizur T. & Livneh Z. (2015), Carcinogenesis. 36, 9, p. 982-991
  • More thoughts on the whole organism challenge

    Authors: Harel D. (2015), Computational Methods in Systems Biology - 13th International Conference, CMSB 2015, Proceedings.
  • Quantitative computerized western blotting in detail

    Authors: Talmi-Frank D., Jaffe C. L. & Baneth G. (2015), Western Blotting. p. 141-150
  • LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme

    Authors: Ali M., Saroha A., Pewzner-Jung Y. & Futerman A. H. (2015), FEBS Letters. 589, 17, p. 2213-2217
  • Phosphoproteomic analysis reveals Smarcb1 dependent EGFR signaling in Malignant Rhabdoid tumor cells

    Authors: Darr J., Klochendler A., Isaac S., Geiger T. & Eden A. (2015), Molecular Cancer. 14, 1, 167
  • The functional relevance of somatic synonymous mutations in melanoma and other cancers

    Authors: Gotea V., Gartner J. J., Qutob N., Elnitski L. & Samuels Y. (2015), Pigment Cell and Melanoma Research. 28, 6, p. 673-684
  • Next generation HLA-haploidentical HSCT

    Authors: Martelli M., Ianni M., Ruggeri L., Falzetti F., Carotti A., Reisner Y. & Velardi A. (2015), Bone Marrow Transplantation. 50, p. S63-S66
  • The EGFR/ERBB receptor family

    Authors: Pareja F., Pines G. & Yarden Y. (2015), Receptor Tyrosine Kinases. L. Wheeler D. & Yarden Y. (eds.). p. 107-164
  • Endothelial thermotolerance impairs nanoparticle transport in tumors

    Authors: Bagley A. F., Scherz-Shouval R., Galie P. A., Zhang A. Q., Wyckoff J., Whitesell L., Chen C. S., Lindquist S. & Bhatia S. N. (2015), Cancer Research. 75, 16, p. 3522-3567
  • Actin flows mediate a universal coupling between cell speed and cell persistence

    Authors: Maiuri P., Rupprecht J., Wieser S., Ruprecht V., Benichou O., Carpi N., Coppey M., De Beco S., Gov N., Heisenberg C., Crespo C. L., Lautenschlaeger F., Le Berre M., Lennon-Dumenil A., Raab M., Thiam H., Piel M., Sixt M. & Voituriez R. (2015), Cell. 161, 2, p. 374-386
  • Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

    Authors: Dumez J. D., Milani J., Vuichoud B., Bornet A., Lalande-Martin J., Tea I., Yon M., Maucourt M., Deborde C., Moing A., Frydman L., Bodenhausen G., Jannin S. & Giraudeau P. (2015), Analyst. 140, 17, p. 5860-5863
  • Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

    Authors: Rabinovich S., Adler L., Yizhak K., Sarver A., Silberman A., Agron S., Stettner N., Sun Q., Brandis A., Helbling D., Korman S., Itzkovitz S., Dimmock D., Ulitsky I., Nagamani S. C. S., Ruppin E. & Erez A. (2015), Nature. 527, 7578, p. 379-383
  • Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation

    Authors: Kim H., Frederick D., Levesque M., Cooper Z., Feng Y., Krepler C., Brill L., Samuels Y., Hayward N., Perlina A., Piris A., Zhang T., Halaban R., Herlyn M., Brown K., Wargo J., Dummer R., Flaherty K. & Ronai Z. (2015), Cell Reports. 11, 9, p. 1458-1473
  • Combining three antibodies nullifies feedback-mediated resistance to erlotinib in lung cancer

    Authors: Mancini M., Gaborit N., Lindzen M., Salame T. M., Dall'Ora M., Sevilla-Sharon M., Abdul-Hai A., Downward J. & Yarden Y. (2015), Science Signaling. 8, 379, ra53
  • Genomic Classification of Cutaneous Melanoma

    Authors: Samuels Y. (2015), Cell. 161, 7, p. 1681-1696
  • Clonal evolution models of tumor heterogeneity

  • Clusterin, a gene enriched in intestinal stem cells, is required for L1-mediated colon cancer metastasis

    Authors: Shapiro B., Tocci P., Haase G., Gavert N. & Ben-Ze'ev A. (2015), Oncotarget. 6, 33, p. 34389-34401
  • Size controlled protein nanoemulsions for active targeting of folate receptor positive cells

    Authors: Loureiro A., Nogueira E., Azoia N. G., Sarria M. P., Abreu A. S., Shimanovich U., Rollett A., Harmark J., Hebert H., Guebitz G., Bernardes G. J. L., Preto A., Gomes A. C. & Cavaco-Paulo A. (2015), Colloids And Surfaces B-Biointerfaces. 135, p. 90-98
  • Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy

    Authors: Golomb L., Sagiv A., Pateras I., Maly A., Krizhanovsky V., Gorgoulis V., Oren M. & Ben-Yehuda A. (2015), Cell Death and Differentiation. 22, 11, p. 1764-1774
  • Peptide Anchor for Folate-Targeted Liposomal Delivery

    Authors: Nogueira E., Mangialavori I. C., Loureiro A., Azoia N. G., Sarria M. P., Nogueira P., Freitas J., Harmark J., Shimanovich U., Rollett A., Lacroix G., Bernardes G. J. L., Guebitz G., Hebert H., Moreira A., Carmo A. M., Rossi J. P. F. C., Gomes A. C., Preto A. & Cavaco-Paulo A. (2015), Biomacromolecules. 16, 9, p. 2904-2910
  • Messenger RNA encoding constitutively active toll-like receptor 4 enhances effector functions of human T cells.

    Authors: Pato A., Eisenberg G., Machlenkin A., Margalit A., Cafri G., Frankenburg S., Merims S., Peretz T., Lotem M. & Gross G. (2015), Clinical and Experimental Immunology. 182, 2, p. 220-229
  • PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition

    Authors: Verma N., Keinan O., Selitrennik M., Karn T., Filipits M. & Lev S. (2015), Nature Communications. 6, 6064
  • Label-free in vivo molecular imaging of underglycosylated mucin-1 expression in tumour cells

    Authors: Song X., Airan R. D., Arifin D. R., Bar-Shir A., Kadayakkara D. K., Liu G., Gilad A. A., van Zijl Z. P. C. M., McMahon M. T. & Bulte J. W. M. (2015), Nature Communications. 6, 6719
  • The Parkinson's-associated protein DJ-1 regulates the 20S proteasome

    Authors: Moscovitz O., Ben-Nissan G., Mizrachi L., Pollack D., Fainer I. & Sharon M. (2015), Nature Communications. 6, 6609
  • A Novel Intravital Imaging Window for Longitudinal Microscopy of the Mouse Ovary

    Authors: Bochner F., Fellus-Alyagor L., Kalchenko V. (., Shinar S. & Neeman M. (2015), Scientific Reports. 5, 12446
  • Mechanical interplay between invadopodia and the nucleus in cultured cancer cells

    Authors: Revach O., Weiner A., Rechav K., Sabanay I., Livne A. & Geiger B. (2015), Scientific Reports. 5, 9466
  • Target discovery for T cell therapy: Next steps to advance Immunotherapies

    Authors: Bot A., Brewer J. E., Eshhar Z., Frankel S. R., Hickman E., Jungbluth A. A., Morgan R., Peretz Y., Radvanyi L., Ramos C. A., Robbins P. F. & Wucherpfennig K. W. (2015), Journal for ImmunoTherapy of Cancer. 3, 1, 31
  • Chemical cross-linking and native mass spectrometry: A fruitful combination for structural biology

    Authors: Sinz A., Arlt C., Chorev D. & Sharon M. (2015), Protein Science. 24, 8, p. 1193-1209
  • TOOKAD® Soluble focal therapy: pooled analysis of three phase II studies assessing the minimally invasive ablation of localized prostate cancer

    Authors: Azzouzi A., Barret E., Bennet J., Moore C., Taneja S., Muir G., Villers A., Coleman J., Allen C., Scherz A. & Emberton M. (2015), World Journal of Urology. 33, 7, p. 945-953
  • Antibody-carbohydrate recognition from docked ensembles using the automap procedure

    Authors: Dingjan T., Agostino M., Ramsland P. A. & Yuriev E. (2015), Methods in Molecular Biology. Lepenies B. (eds.). p. 41-55
  • Electron spin resonance microscopic imaging of oxygen concentration in cancer spheroids

    Authors: Hashem M., Weiler-Sagie M., Kuppusamy P., Neufeld G., Neeman M. & Blank A. (2015), JOURNAL OF MAGNETIC RESONANCE. 256, p. 77-85
  • Aging, clonal hematopoiesis and preleukemia: not just bad luck?

    Authors: Shlush L. I., Zandi S., Itzkovitz S. & Schuh A. C. (2015), International Journal of Hematology. 102, 5, p. 513-522
  • Development of pheochromocytoma in ceramide synthase 2 null mice

    Authors: Park W., Brenner O., Kogot-Levin A., Saada A., Merrill A., Pewzner-Jung Y. & Futerman A. H. (2015), Endocrine-Related Cancer. 22, 4, p. 623-632
  • Runx3 at the interface of immunity, inflammation and cancer

    Authors: Lotem J., Levanon D., Negreanu V., Bauer O., Hantisteanu S., Dicken J. & Groner Y. (2015), Biochimica Et Biophysica Acta-Reviews On Cancer. 1855, 2, p. 131-143
  • P53-dependent non-coding RNA networks in chronic lymphocytic leukemia

    Authors: Blume C. J., Hotz-Wagenblatt A., Hüllein J., Sellner L., Jethwa A., Stolz T., Slabicki M., Lee K., Sharathchandra A., Benner A., Dietrich S., Oakes C. C., Dreger P., Te Raa D., Kater A. P., Jauch A., Merkel O., Oren M., Hielscher T. & Zenz T. (2015), Leukemia. 29, 10, p. 2015-2023
  • Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments

    Authors: Schevzov G., Kee A., Wang B., Sequeira V., Hook J., Coombes J., Lucas C., Stehn J., Musgrove E., Cretu A., Assoian R., Fath T., Hanoch T., Seger R., Pleines I., Kile B., Hardeman E. & Gunning P. (2015), Molecular Biology of the Cell. 26, 13, p. 2475-2490
  • Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer

    Authors: George B., Horn D., Bayo P., Zaoui K., Flechtenmacher C., Grabe N., Plinkert P., Krizhanovsky V. & Hess J. (2015), Cancer Letters. 358, 2, p. 191-199
  • Dispersal of an ancient retroposon in the TP53 promoter of Bovidae: Phylogeny, novel mechanisms, and potential implications for cow milk persistency

    Authors: Dekel Y., Machluf Y., Ben-Dor S., Yifa O., Stoler A., Ben-Shlomo I. & Bercovich D. (2015), BMC Genomics. 16, 1, 53
  • Compressed sensing for longitudinal MRI: An adaptive-weighted approach

    Authors: Weizman L., Eldar Y. C. & Ben Bashat D. (2015), Medical Physics. 42, 9, p. 5195-5208
  • Regulation of Elg1 activity by phosphorylation

    Authors: Shkedy D., Singh N., Shemesh K., Amir A., Geiger T., Liefshitz B., Harari Y. & Kupiec M. (2015), Cell cycle (Georgetown, Tex.). 14, 23, p. 3689-3697
  • c-Abl forces YAP to switch sides.

    Authors: Keshet R., Reuven N. & Shaul Y. (2015), Molecular & cellular oncology. 2, 3, p. e995006, 27308475
  • Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles

    Authors: Ramishetti S., Kedmi R., Goldsmith M., Leonard F., Sprague A. G., Godin B., Gozin M., Cullis P. R., Dykxhoorn D. M. & Peer D. (2015), ACS Nano. 9, 7, p. 6706-6716
  • From mass cytometry to cancer prognosis

    Authors: Winter D. R., Ledergor G. & Amit I. (2015),
  • Down-regulation of LATS kinases alters p53 to promote cell migration

    Authors: Furth N., Bossel Ben-Moshe B. N., Pozniak Y., Porat Z., Geiger T., Domany E., Aylon Y. & Oren M. (2015), Genes and Development. 29, p. 2325-2330
  • Epigenetic silencing of miR-145-5p contributes to brain metastasis

    Authors: Donzelli S., Mori F., Bellissimo T., Sacconi A., Casini B., Frixa T., Roscilli G., Aurisicchio L., Facciolo F., Pompili A., Carosi M. A., Pescarmona E., Segatto O., Pond G., Muti P., Telera S., Strano S., Yarden Y. & Blandino G. (2015), Oncotarget. 6, 34, p. 35183-35201
  • Historic recollections: From polymers and proteins to autoimmunity and cancer.

  • Tumor-derived osteopontin reprograms normal mammary fibroblasts to promote inflammation and tumor growth in breast cancer

    Authors: Sharon Y., Raz Y., Cohen N., Ben-Shmuel A., Schwartz H., Geiger T. & Erez N. (2015), Cancer Research. 75, 6, p. 963-973
  • PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

    Authors: Cohen S. G., Itkin T., Chakrabarty S., Graf C., Kollet O., Ludin A., Golan K., Kalinkovich A., Ledergor G., Wong E., Niemeyer E., Porat Z., Erez A., Sagi I., Esmon C. T., Ruf W. & Lapidot T. (2015), Nature Medicine. 21, 11, p. 1307-1317
  • Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors

    Authors: Loureiro A., Bernardes G. J. L., Shimanovich U., Sarria M. P., Nogueira E., Preto A., Gomes A. C. & Cavaco-Paulo A. (2015), Nanomedicine: Nanotechnology, Biology, and Medicine. 11, 5, p. 1077-1083
  • Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli

    Authors: Cronk J. C., Derecki N. C., Ji E., Xu Y., Lampano A. E., Smirnov I., Baker W., Norris G. T., Marin I., Coddington N., Wolf Y., Turner S. D., Aderem A., Klibanov A. L., Harris T. H., Jung S., Litvak V. & Kipnis J. (2015), Immunity. 42, 4, p. 679-691
  • Metabolic dysregulation in monogenic disorders and cancer-finding method in madness

    Authors: Erez A. & DeBerardinis R. J. (2015), Nature reviews. Cancer. 15, 7, p. 440-448
  • C-Abl antagonizes the YAP oncogenic function

    Authors: Keshet R. D., Adler J., Lax I. R., Shanzer M. H., Porat Z., Reuven N. & Shaul Y. (2015), Cell Death and Differentiation. 22, 6, p. 935-945
  • Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression

    Authors: Shvab A., Haase G., Ben Shmuel S. A., Gavert N., Brabletz T., Dedhar S. & Ben-Ze'ev A. (2015), Oncogene. 35, 5, p. 549-557
  • Overshoot during phenotypic switching of cancer cell populations

    Authors: Sellerio A., Ciusani E., Ben-Moshe N. B., Coco S., Piccinini A., Myers C., Sethna J., Giampietro C., Zapperi S. & La Porta P. C. (2015), Scientific Reports. 5, 15464
  • Modeling the finger instability in an expanding cell monolayer

    Authors: Tarle V., Ravasio A., Hakim V. & Gov N. (2015), Integrative Biology. 7, 10, p. 1218-1227
  • PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop

    Authors: Selitrennik M. & Lev S. (2015), Oncotarget. 6, 26, p. 22214-22226
  • Aptamer Targeting the ERBB2 Receptor Tyrosine Kinase for Applications in Tumor Therapy

    Authors: Mahlknecht G., Sela M. & Yarden Y. (2015), Gene Therapy of Solid Cancers. p. 3-15
  • The nuclear translocation of ERK1/2 as an anticancer target

    Authors: Plotnikov A., Flores K., Maik-Rachline G., Zehorai E., Kapri-Pardes E., Berti D. A., Hanoch T., Besser M. J. & Seger R. (2015), Nature Communications. 6, 6685
  • Determination of optimal drug dose and light dose index to achieve minimally invasive focal ablation of localised prostate cancer using WST11-vascular-targeted photodynamic (VTP) therapy

    Authors: Moore C. M., Azzouzi A., Barret E., Villers A., Muir G. H., Barber N. J., Bott S., Trachtenberg J., Arumainayagam N., Gaillac B., Allen C., Schertz A. & Emberton M. (2015), BJU International. 116, 6, p. 888-896
  • Inferring biological tasks using Pareto analysis of high-dimensional data

    Authors: Hart Y., Sheftel H., Hausser J., Szekely P., Ben-Moshe N. B., Korem Y., Tendler A., Mayo A. E. & Alon U. (2015), Nature Methods. 12, 3, p. 233-+
  • Photodynamic Quenched Cathepsin Activity Based Probes for Cancer Detection and Macrophage Targeted Therapy

    Authors: Ben-Nun Y., Merquiol E., Brandis A., Turk B., Scherz A. & Blum G. (2015), Theranostics. 5, 8, p. 847-862
  • Single Exposure to near Roadway Particulate Matter Leads to Confined Inflammatory and Defense Responses: Possible Role of Metals

    Authors: Pardo M., Shafer M. M., Rudich A., Schauer J. & Rudich Y. (2015), Environmental Science and Technology. 49, 14, p. 8777-8785
  • Cancer immunotherapy: More is (much) better

    Authors: Yarden Y. & Sela M. (2015), Clinical Cancer Research. 21, 18, p. 4030-4032
  • The role of C/EBP-β LIP in multidrug resistance

    Authors: Riganti C., Kopecka J., Panada E., Barak S. & Rubinstein M. (2015), JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 107, 5
  • Combined local blood-brain barrier opening and systemic methotrexate for the treatment of brain tumors

    Authors: Cooper I., Last D., Guez D., Sharabi S., Goldman S. E., Lubitz I., Daniels D., Salomon S., Tamar G., Tamir T., Mardor R., Fridkin M., Shechter Y. & Mardor Y. (2015), Journal of Cerebral Blood Flow and Metabolism. 35, 6, p. 967-976
  • Cardiac glycosides induced toxicity in human cells expressing α1-, α2-, or α3-isoforms of Na-K-ATPase

    Authors: Lev M., Karlish S. & Garty H. (2015), American Journal Of Physiology-Cell Physiology. 309, 2, p. C126-C135
  • Erratum to FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis [Cancer Cell 28, 285-295; September 14, 2015]

    Authors: Dahan R., Sega E., Engelhardt J., Selby M., Korman A. J. & Ravetch J. V. (2015),
  • The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner

    Authors: Shanzer M., Ricardo-Lax I., Keshet R., Reuven N. & Shaul Y. (2015), Oncogene. 34, 32, p. 4190-4198
  • Exercising 'veto' power to make haploidentical hematopoietic stem cell transplantation a safe modality for induction of immune tolerance

    Authors: Or Geva N. & Reisner Y. (2015), Regenerative Medicine. 10, 3, p. 239-242
  • MicroRNAs and Growth Factors: An Alliance Propelling Tumor Progression.

  • Laparoscopic versus open liver resection for metastatic colorectal cancer

    Authors: Nachmany I., Pencovich N., Zohar N., Ben-Yehuda A., Binyamin C., Goykhman Y., Lubezky N., Nakache R. & Klausner J. M. (2015), EJSO. 41, 12, p. 1615-1620
  • Overcoming limitations in diffusion-weighted MRI of breast by spatio-temporal encoding

    Authors: Solomon E., Nissan N., Furman-Haran E., Seginer A., Shapiro-Feinberg M., Degani H. & Frydman L. (2015), Magnetic Resonance in Medicine. 73, 6, p. 2163-2173
  • YAP and the drug resistance highway

    Authors: Keren-Paz A., Emmanuel R. & Samuels Y. (2015),
  • mRNA-transfected Dendritic Cells Expressing Polypeptides That Link MHC-I Presentation to Constitutive TLR4 Activation Confer Tumor Immunity

    Authors: Cafri G., Sharbi Yunger Y. A., Tzehoval E., Alteber Z., Gross T., Vadai E., Margalit A., Gross G. & Eisenbach L. (2015), Molecular Therapy. 23, 8, p. 1391-1400
  • Haploidentical hematopoietic stem cell transplantation: State of art

    Authors: Reisner Y., Aversa F. & Martelli M. (2015), Bone Marrow Transplantation. 50, p. S1-S5
  • Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody

    Authors: Udi Y., Grossman M., Solomonov I., Dym O., Rozenberg H., Moreno V., Cuniasse P., Dive V., Arroyo A. G. & Sagi I. (2015), Structure. 23, 1, p. 104-115
  • Tumor Suppressor Activity of Klotho in Breast Cancer is Revealed by Structure-function Analysis.

  • Matrix Metalloproteinase Biology

    Authors: Sagi I. & Gaffney J. P. (2015),
  • Tumor-specific expression and detection of a CEST reporter gene

    Authors: Minn I., Bar-Shir A., Yarlagadda K., Bulte J. W., Fisher P. B., Wang H., Gilad A. A. & Pomper M. G. (2015), Magnetic Resonance in Medicine. 74, 2, p. 544-549
  • Serum Creatinine Versus Plasma Methotrexate Levels to Predict Toxicities in Children Receiving High-dose Methotrexate

    Authors: Tiwari P., Thomas M. K., Pathania S., Dhawan D., Gupta Y. K., Vishnubhatla S. & Bakhshi S. (2015), Pediatric Hematology and Oncology. 32, 8, p. 576-584
  • Regulation of epithelial cell organization by tuning cell-substrate adhesion

    Authors: Ravasio A., Phuong Le A., Thuan B. S., Tarle V., Ong H. T., Bertocchi C., Mege R., Lim C. T., Gov N. & Ladoux B. (2015), Integrative Biology (United Kingdom). 7, 10, p. 1228-1241
  • EGF induces microRNAs that target suppressors of cell migration: MiR-15b targets MTSS1 in breast cancer

    Authors: Kedmi M., Ben Chetrit C. N., Koerner C., Mancini M., Ben-Moshe N. B., Lauriola M., Lavi S., Biagioni F., Carvalho S., Cohen-Dvashi H., Schmitt F., Wiemann S., Blandino G. & Yarden Y. (2015), Science Signaling. 8, 368, p. ra29
  • Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

    Authors: Golani O., Naffar-Abu-Amara S. & Geiger B. (2015), The Journal of Clinical Investigation. 125, 4, p. 1648-1664
  • Receptor tyrosine kinases: Structure, functions and role in human disease

    Authors: Wheeler D. L. & Yarden Y. (2015),
  • Inflammatory mechanisms of infection-associated cancer

    Authors: Suez J., Levy M., Thaiss C. A. & Elinav E. (2015), Infection and Cancer. R. Shurin M., Ismail N. & Thanavala Y. (eds.). p. 151-167
  • Modeling and Predicting Optimal Treatment Scheduling Between the Antiangiogenic Drug Sunitinib and Irinotecan in Preclinical Settings

    Authors: Wilson S., Tod M., Ouerdani A., Emde A., Yarden Y., Berkane A. A., Kassour S., Wei M. X., Freyer G., You B., Grenier E. & Ribba B. (2015), CPT: Pharmacometrics and Systems Pharmacology. 4, 12, p. 720-727
  • Tyrosine phosphorylation of WW proteins

    Authors: Reuven N., Shanzer M. & Shaul Y. (2015), Experimental Biology and Medicine. 240, 3, p. 375-382
  • Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma

    Authors: Kurscheid S., Bady P., Sciuscio D., Samarzija I., Shay T., Vassallo I., Criekinge W. V., Daniel R. T., van den Bent d. B. M. J., Marosi C., Weller M., Mason W. P., Domany E., Stupp R., Delorenzi M. & Hegi M. E. (2015), Genome Biology. 16, 1, 16
  • Tumor-associated and disease-associated autoantibody repertoires in healthy colostrum and maternal and newborn cord sera

    Authors: Madi A., Bransburg-Zabary S., Maayan-Metzger A., Dar G., Ben-Jacob E. & Cohen I. R. (2015), Journal of Immunology. 194, 11, p. 5272-5281
  • Biopsy-induced inflammatory conditions improve endometrial receptivity: The mechanism of action

    Authors: Gnainsky Y., Granot I., Aldo P., Barash A., Or Y., Mor G. & Dekel N. (2015), Reproduction. 149, 1, p. 75-85
  • Recurrent inactivating RASA2 mutations in melanoma

    Authors: Arafeh R., Qutob N., Emmanuel R., Keren-Paz A., Madore J., Elkahloun A., Wilmott J. S., Gartner J. J., Di Pizio A., Winograd-Katz S., Sindiri S., Rotkopf R., Dutton-Regester K., Johansson P., Pritchard A. L., Waddell N., Hill V. K., Lin J. C., Hevroni Y., Rosenberg S. A., Khan J., Ben-Dor S., Niv M. Y., Ulitsky I., Mann G. J., Scolyer R. A., Hayward N. K. & Samuels Y. (2015), Nature Genetics. 47, 12, p. 1408-1410
  • The tyrosine kinase c-Abl promotes homeodomaininteracting protein kinase 2 (HIPK2) accumulation and activation in response to DNA damage

    Authors: Reuven N., Adler J., Porat Z., Polonio-Vallon T., Hofmann T. & Shaul Y. (2015), Journal of Biological Chemistry. 290, 27, p. 16478-16488
  • Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

    Authors: Ben Chetrit C. N., Chetrit D., Russell R., Koerner C., Mancini M., Abdul-Hai A., Itkin T., Carvalho S., Cohen-Dvashi H., Koestler W. J., Shukla K., Lindzen M., Kedmi M., Lauriola M., Shulman Z., Barr H., Seger D., Ferraro D. A., Pareja F., Gil-Henn H., Lapidot T., Alon R., Milanezi F., Symons M., Ben Hamo H. R., Efroni S., Schmitt F., Wiemann S., Caldas C., Ehrlich M. & Yarden Y. (2015), Science Signaling. 8, 360, ra7
  • Gap geometry dictates epithelial closure efficiency

    Authors: Ravasio A., Cheddadi I., Chen T., Pereira T., Ong H. T., Bertocchi C., Brugues A., Jacinto A., Kabla A. J., Toyama Y., Trepat X., Gov N., de Almeida L. N. & Ladoux B. (2015), Nature Communications. 6, 7683
  • Collective cell motility promotes chemotactic prowess and resistance to chemorepulsion

    Authors: Malet-Engra G., Yu W., Oldani A., Rey-Barroso J., Gov N., Scita G. & Dupre L. (2015), Current Biology. 25, 2, p. 242-250
  • Physics of active jamming during collective cellular motion in a monolayer

    Authors: Garcia S., Hannezo E., Elgeti J., Joanny J. F., Silberzan P. & Gov N. S. (2015), Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. 15314-15319
  • The cancer genome

    Authors: Samuels Y., Bardelli A., Gartner J. J. & López-Otin C. (2015), DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology: Tenth Edition.
  • The MAPK Signaling Cascades

    Authors: Seger R. & Wexler S. (2015), Encyclopedia of Cell Biology. Vol. 3. p. 122-127
  • The BH3-only protein BID impairs the p38-mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice

    Authors: Orlik J., Schüngel S., Buitrago-Molina L. E., Marhenke S., Geffers R., Endig J., Lobschat K., Rössler S., Goeppert B., Manns M. P., Gross A. & Vogel A. (2015), Hepatology. 62, 3, p. 816-828
  • Hepatitis B virus induces RNR-R2 expression via DNA damage response activation

    Authors: Ricardo Lax L. I., Ramanan V., Michailidis E., Shamia T., Reuven N., Rice C., Shlomai A. & Shaul Y. (2015), Journal of Hepatology. 63, 4, p. 789-796
  • Extracellular matrix regulation of ErbB3 in a subset of wild-type BRAF/NRAS melanoma

    Authors: Rosenbaum S., Capparelli C., Berman-Booty L., Gaborit N., Zhan T., Davies M., Setiady Y., Yarden Y. & Aplin A. (2015),
  • Fluorine-19 labeling of stromal vascular fraction cells for clinical imaging applications

    Authors: Rose L. C., Kadayakkara D. K., Wang G., Bar-Shir A., Helfer B. M., OHanlon C. F., Kraitchman D. L., Rodriguez R. L. & Bulte J. W. (2015), Stem cells translational medicine. 4, 12, p. 1472-1481
  • Pathway-based personalized analysis of breast cancer expression data

    Authors: Livshits A., Git A., Fuks G., Caldas C. & Domany E. (2015), Molecular Oncology. 9, 7, p. 1471-1483
  • Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression

    Authors: Cohen-Dvashi H., Ben Chetrit C. N., Russell R., Carvalho S., Lauriola M., Nisani S., Mancini M., Nataraj N., Kedmi M., Roth L., Koestler W., Zeisel A., Yitzhaky A., Zylberg J., Tarcic G., Eilam R., Wigelman Y., Will R., Lavi S., Porat Z., Wiemann S., Ricardo S., Schmitt F., Caldas C. & Yarden Y. (2015), EMBO Molecular Medicine. 7, 3, p. 299-314
  • P53 orchestrates between normal differentiation and cancer

    Authors: Rivlin N., Koifman G. & Rotter V. (2015), Seminars in Cancer Biology. 32, p. 10-17
  • The molecular basis for functional plasticity in type I interferon signaling

    Authors: Schreiber G. & Piehler J. (2015), Trends in Immunology. 36, 3, p. 139-149
  • ErbB3-ErbB2 complexes as a therapeutic target in a subset of wild-type BRAF/NRAS cutaneous melanomas

    Authors: Capparelli C., Rosenbaum S., Berman-Booty L. D., Salhi A., Gaborit N., Zhan T., Chervoneva I., Roszik J., Woodman S. E., Davies M. A., Setiady Y. Y., Osman I., Yarden Y. & Aplin A. E. (2015), Cancer Research. 75, 17, p. 3554-3567