A factor in ovarian cancer onset
The most common and deadliest type of ovarian cancer is high-grade serous ovarian cancer (HGSC). A study co-authored by Prof. Moshe Oren of the Department of Molecular Cell Biology—in collaboration with colleagues from the University of Pennsylvania and elsewhere—reveals the identification of an early event in the development of this disease. The scientists found that the loss of a molecule called RNF20 promotes the expression of IL6, a protein that plays a part in the migratory capacity of aggressive cancers. These findings may eventually contribute to novel strategies for the early diagnosis of high-grade serous ovarian cancer.