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Stress and mutation dependencies in the tumor microenvironment

Date:
05
Thursday
June
2025
Lecture / Seminar
Time: 14:00-15:00
Location: Candiotty Auditorium
Lecturer: Prof. Ruth Scherz-Shouval
Organizer: Dwek Institute for Cancer Therapy Research

The protective role of physical activity on melanoma brain metastases

Date:
24
Thursday
July
2025
Lecture / Seminar
Time: 14:00-15:00
Location: Candiotty
Lecturer: Prof. Carmit Levy
Organizer: Dwek Institute for Cancer Therapy Research

Michael Sela Memorial Symposium - From Synthetic Models to Immunotherapy

Date:
03
Wednesday
June
2026
-
04
Thursday
June
2026
Conference
Time: 08:00
Location: The David Lopatie Conference Centre
Contact: ronen.alon@weizmann.ac.il

    Past

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    Cancer aneuploidy: From evolutionary pressures to cellular vulnerabilities

    Date:
    22
    Thursday
    May
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Uri Ben-David
    Organizer: Dwek Institute for Cancer Therapy Research

    The Clore Center for Biological Physics

    Date:
    18
    Sunday
    May
    2025
    Lecture / Seminar
    Time: 12:45-14:30
    Title: When Will the Cancer Start?
    Location: Nella and Leon Benoziyo Physics Library
    Lecturer: Anatoly B. Kolomeisky
    Contact: debbie.hen@weizmann.ac.il
    Abstract: Cancer is a genetic disease that results from accumulation of unfavorable mutati ... Read more Cancer is a genetic disease that results from accumulation of unfavorable mutations. As soon as genetic and epigenetic modifications associated with these mutations become strong enough, the uncontrolled tumor cell growth is initiated, eventually spreading through healthy tissues. Clarifying the dynamics of initiation is critically important for understanding the mechanisms of cancer. Here we present a new theoretical approach, stimulated by analogy with chemical reactions and other stochastic processes in physics and biology, to evaluate the dynamic processes associated with cancer initiation. It is based on a discrete-state stochastic description of the formation of tumors as a fixation of unfavorable mutations. Thus, the main idea is to map complex processes of cancer initiation into a network of stochastic transitions between specific states of the tissue. Using a first-passage analysis, the probabilities for cancer to appear and the average times before this happens are explicitly calculated. The method is applied for estimating the initiation times from clinical data for 28 different types of cancer. It is found, surprisingly, that the higher probability of cancer to occur does not necessarily lead to the fast starting the cancer. This suggests that both lifetime risks and cancer initiation times must be used to evaluate the possibility of appearance of the cancer tumor.  The similarity of the mechanisms of cancer initiation processes with dynamics of chemical reactions are discussed.  Furthermore, it is shown that the order of mutations might lead to different cancer initiation dynamics, explaining surprising experimental observations that order of mutations can affect the cancer outcome. Our view of cancer initiation as a motion in the effective free-energy landscape provides new insights into the mechanisms of these complex processes. FOR THE LATEST UPDATES AND CONTENT ON SOFT MATTER AND BIOLOGICAL PHYSICS AT THE WEIZMANN, VISIT OUR WEBSITE: https://www.biosoftweizmann.com/    
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    Targeting leukemia cell vulnerabilities with our experimental new drug

    Date:
    14
    Wednesday
    May
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Yinon Ben-Neriah
    Organizer: Dwek Institute for Cancer Therapy Research

    EARLY-ONSET GI CANCER – AN EVOLVING ENTITY

    Date:
    08
    Thursday
    May
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Irit Ben-Aharon MD, PhD
    Organizer: Dwek Institute for Cancer Therapy Research

    Recent advances in Flow Cytometry – from nano-particles to whole organisms

    Date:
    08
    Thursday
    May
    2025
    Lecture / Seminar
    Time: 09:00-10:00
    Location: Candiotty Auditorium
    Lecturer: Dr. Ziv Porat
    Organizer: Department of Life Sciences Core Facilities
    Contact: ziv.porat@weizmann.ac.il

    Pathways Regulating Neutrophil Function in Cancer.

    Date:
    24
    Thursday
    April
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Zvika Granot
    Organizer: Dwek Institute for Cancer Therapy Research

    Molecular principles underlying aggressive cancers

    Date:
    10
    Thursday
    April
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Ruth Nussinov
    Organizer: Dwek Institute for Cancer Therapy Research

    The Nexus of Genome Stability, Cancer, Senescence, and Aging: New Insights, New Players

    Date:
    03
    Thursday
    April
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Yosef Shilo
    Organizer: Moross Integrated Cancer Center (MICC)

    Metabolism, Clonality and Immunotherapy: A Single-Cell PerspectiveTo be announced

    Date:
    27
    Thursday
    March
    2025
    Lecture / Seminar
    Time: 15:00-16:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Dr. Keren Yizhak
    Abstract: Understanding why some patients respond to immune checkpoint therapy while other ... Read more Understanding why some patients respond to immune checkpoint therapy while others do not remains a critical challenge in cancer research. This talk will explore three key studies that shed light on this question. First, we uncover metabolic predictors of response to checkpoint blockade therapy, revealing how tumor and immune cell metabolism shape treatment outcomes. Next, we present a single-cell meta-analysis of T cell clonal dynamics, highlighting their role in immunotherapy success. Finally, we introduce scXpand, a machine-learning approach for predicting T cell clonality from scRNA-seq, offering a novel tool to enhance immunotherapy research and precision medicine.
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    Regulation of immune cell function in tumor microenvironment of triple-negative breast cancer

    Date:
    27
    Thursday
    March
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Idit Shachar
    Organizer: Dwek Institute for Cancer Therapy Research

    Spatial transcriptomics of pancreatic cancer development and immune cells targeting to restrict tumor growth

    Date:
    20
    Thursday
    March
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Oren Parnas
    Organizer: Dwek Institute for Cancer Therapy Research

    Harnessing Mistakes to Expose Cancer’s Vulnerability

    Date:
    20
    Thursday
    March
    2025
    Lecture / Seminar
    Time: 12:30-14:00
    Title: Spotlight on Science lecture sponsored by the Staff Scientists Council
    Location: Gerhard M.J. Schmidt Lecture Hall
    Lecturer: Ilana Eyal
    Contact: mark.a.iron@weizmann.ac.il
    Abstract: Over the past few decades, immunotherapy has revolutionized cancer treatment wit ... Read more Over the past few decades, immunotherapy has revolutionized cancer treatment with great success in treating cancer patients and preventing tumor recurrence after surgery. Harnessing the immune system to fight cancer largely relies on the ability of T lymphocytes to distinguish between “self” and “non-self” to specifically identify and eliminate malignant cells. This is achieved through the recognition of neoantigens, tumor-specific proteins resulting from genetic mutations.The Samuels’ lab is exploring the immune-tumor interactions, with specific focus on the mechanisms underlying cancer-cell recognition, and developing novel strategies to increase antitumor immune responses.In this talk, I will present results from our recent studies investigating the link between mRNA mistranslation in cancer cells and immunological tumor control.
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    Converging on the cell state that underlies therapeutic resistance in melanoma & prioritizing therapeutic targets

    Date:
    20
    Thursday
    February
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Keith Flaherty
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    The expanding world of PD-L1 activities and regulation in breast cancer – N-linked glycosylation and beyond

    Date:
    20
    Thursday
    February
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Adit Ben-Baruch
    Organizer: Dwek Institute for Cancer Therapy Research

    PhD Thesis Defense - Elinor Gigi - Straussman lab

    Date:
    19
    Wednesday
    February
    2025
    Lecture / Seminar
    Time: 14:30-16:00
    Title: The glioblastoma and brain metastases microbiome
    Location: Ullmann Building of Life Sciences

    PhD Thesis Defense - Noam Galili Darnell -Prof Itay Tirosh lab

    Date:
    09
    Sunday
    February
    2025
    Lecture / Seminar
    Time: 13:00-15:00
    Title: Deciphering Glioma Organization and Chromosome Copy Number Variability
    Location: Zoom

    Senescent cells on the crossroads of cancer and aging

    Date:
    06
    Thursday
    February
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Candiotty Auditorium
    Lecturer: Prof. Valery Krizhanovsky
    Organizer: Moross Integrated Cancer Center (MICC)

    The Clore Center for Biological Physics

    Date:
    02
    Sunday
    February
    2025
    Lecture / Seminar
    Time: 12:45-14:30
    Title: Design principles of protein-DNA Recognition Specificity in Embryonic Stem Cells
    Location: Nella and Leon Benoziyo Physics Building
    Lecturer: David B. Lukatsky
    Organizer: Clore Center for Biological Physics
    Contact: debbie.hen@weizmann.ac.il
    Abstract: Transcription factors (TFs) bind genomic DNA regulating gene expression and deve ... Read more Transcription factors (TFs) bind genomic DNA regulating gene expression and developmental programs in embryonic stem cells (ESCs). Even though comprehensive genome-wide molecular maps for TF-DNA binding are experimentally available for key pluripotency-associated TFs, the understanding of molecular design principles responsible for TF-DNA recognition remains incomplete. In this talk, I will show that binding preferences of key pluripotency TFs exhibit bimodality in the local GC-content distribution. Sequence-dependent binding specificity of these TFs is distributed across three major contributions. First, local GCcontent is dominant in high-GC-content regions. Second, recognition of specific k-mers is predominant in low-GC-content regions. Third, short tandem repeats (STRs) are highly predictive in both low- and high-GC-content regions. In sharp contrast, binding preferences of a key oncogenic protein, c-Myc, are exclusively dominated by local GC-content and STRs in high-GC-content genomic regions. I will propose that the transition in the TF-DNA binding landscape upon ESC differentiation is solely regulated by the concentration of c-Myc, which forms a bivalent c-Myc-Max heterotetramer upon promoter binding, competing with key pluripotency factors. Taken together, these findings point out that c-Myc may significantly affect the genome-wide TF-DNA binding landscape, chromatin structure, and enhancerpromoter interactions.FOR THE LATEST UPDATES AND CONTENT ON SOFT MATTER AND BIOLOGICAL PHYSICS AT THE WEIZMANN, VISIT OUR WEBSITE: https://www.biosoftweizmann.com/
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    Genomic and functional approaches to modeling and targeting cancer aneuploidy announced

    Date:
    30
    Thursday
    January
    2025
    Lecture / Seminar
    Time: 15:00-16:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Prof. Uri Ben-David,Prof. Uri Ben-David
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Aneuploidy, an imbalanced number of chromosomes or chromosome arms, is a genetic ... Read more Aneuploidy, an imbalanced number of chromosomes or chromosome arms, is a genetic hallmark of cancer cells, yet aneuploidy remains a biological enigma and a missed opportunity for cancer therapy. My lab applies experimental and computational approaches to dissect the basic biology underlying cancer aneuploidy and to study its cellular consequences. In this seminar, I will focus on an unpublished study in which we discovered an important role for a recurrent aneuploidy in driving brain metastasis, revealed the underlying molecular mechanism, and identified a therapeutically-relevant cellular vulnerability that is associated with this common aneuploidy.
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    "Though the city used to be called Luz" –SIRT6, aging and beyond.

    Date:
    22
    Wednesday
    January
    2025
    Lecture / Seminar
    Time: 11:00-12:00
    Title: The mammalian longevity associated acetylome
    Location: Arthur and Rochelle Belfer Building for Biomedical Research
    Lecturer: Dr. Haim Cohen
    Organizer: Sagol Institute for Longevity Research
    Contact: urialonw@gmail.com
    Abstract: Despite extensive studies at the genomic, transcriptomic, and metabolomic levels ... Read more Despite extensive studies at the genomic, transcriptomic, and metabolomic levels, the underlying mechanisms regulating longevity remain incompletely understood. Post-translational protein acetylation has been suggested to regulate aspects of longevity. To further explore the role of acetylation, we developed the PHARAOH computational tool, based on the 100-fold differences in longevity within the mammalian class. Analyzing acetylome and proteome data across 107 mammalian species identified multiple significant longevity-associated acetylated lysine residues in mice and humans, controlling many longevity-related pathways. Specifically, we found that longevity-associated acetylation sites help resolve the Peto Paradox: the enigma of why animals with increased body size live longer yet do not exhibit much higher cancer incidence. Our findings show a significant positive correlation between these new acetylation sites and protection against multiple types of cancer in humans. Moreover, mutating these sites reduced the anti-neoplastic functions of the acetylated proteins. These findings provide new insights into the pivotal role of protein acetylation in mammalian longevity, suggesting potential interventions to extend human healthspan.
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    Harnessing Cancer Paradigms for the Treatment of Heart Failure and Fibrosis

    Date:
    16
    Thursday
    January
    2025
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ami Aronheim
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZw ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Reprogramming the Immune System: A New Avenue in Cancer Treatment

    Date:
    19
    Thursday
    December
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Mira Barda-Saad
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: michal.av@weizmann.ac.il
    Details: For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd= ... Read more For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09 Meeting ID: 506 540 2023 Password: 223081
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    Exploring the tumor macroenvironment to improve cancer diagnosis and therapy

    Date:
    12
    Thursday
    December
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ayelet Erez,Prof. Ayelet Erez
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZw ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    PhD Thesis Defenseת Rotem Tal -Itay Tirosh lab

    Date:
    09
    Monday
    December
    2024
    Lecture / Seminar
    Time: 10:00-12:00
    Title: Molecular subtyping of pancreatic cancer
    Location: Ullmann Building of Life Sciences

    PhD Thesis Defenseת Rotem Tal -Itay Tirosh lab

    Date:
    09
    Monday
    December
    2024
    Lecture / Seminar
    Time: 10:00-12:00
    Title: Molecular subtyping of pancreatic cancer
    Location: Ullmann Building of Life Sciences

    PhD Thesis Defenseת Rotem Tal -Itay Tirosh lab

    Date:
    09
    Monday
    December
    2024
    Lecture / Seminar
    Time: 10:00-12:00
    Title: Molecular subtyping of pancreatic cancer
    Location: Ullmann Building of Life Sciences

    PhD Thesis Defenseת Rotem Tal -Itay Tirosh lab

    Date:
    09
    Monday
    December
    2024
    Lecture / Seminar
    Time: 10:00-12:00
    Title: Molecular subtyping of pancreatic cancer
    Location: Ullmann Building of Life Sciences
    Contact: DIKLA.ALKESLASI@WEIZMANN.AC.IL

    PhD Thesis Defenseת Rotem Tal -Itay Tirosh lab

    Date:
    09
    Monday
    December
    2024
    Lecture / Seminar
    Time: 10:00-12:00
    Title: Molecular subtyping of pancreatic cancer
    Location: Ullmann Building of Life Sciences
    Lecturer: Rotem Tal
    Organizer: Department of Molecular Cell Biology
    Contact: DIKLA.ALKESLASI@WEIZMANN.AC.IL

    PhD Thesis Defense Rotem Tal - Itay Tirosh lab

    Date:
    09
    Monday
    December
    2024
    Lecture / Seminar
    Time: 10:00-12:00
    Title: Molecular subtyping of pancreatic cancer
    Location: Ullmann Building of Life Sciences
    Lecturer: Calanit Raanan
    Organizer: Department of Molecular Cell Biology
    Contact: DIKLA.ALKESLASI@WEIZMANN.AC.IL

    Spatial Analysis of Development and Cancer

    Date:
    05
    Thursday
    December
    2024
    Conference
    Time: 08:00
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: yosef.yarden@weizmann.ac.il

    Cellular senescence: roles in regulation of pancreatic function and tumorigenesis

    Date:
    28
    Thursday
    November
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ittai Ben Porath
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: michalav@weizmann.ac.il
    Details: For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd= ... Read more For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09 Meeting ID: 506 540 2023 Password: 223081
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    Towards enhancing immunotherapy - Insights from functional genomics.

    Date:
    21
    Thursday
    November
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Daniel Peeper
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Revisiting the Neoantigen Approach to Cancer Immunotherapy

    Date:
    14
    Thursday
    November
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Yardena Samuels
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: michalav@weizmann.ac.il
    Details: For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd= ... Read more For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09 Meeting ID: 506 540 2023 Password: 223081
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    PhD Thesis Defense - Hila Tishler (Prof. Ayelet Erez Lab)

    Date:
    14
    Thursday
    November
    2024
    Lecture / Seminar
    Time: 11:30
    Title: Enhancing the Sensitivity of Triple Negative Breast Cancers to JAK-STAT Inhibitors by Targeting Arginine Availability
    Location: Ullmann Building of Life Sciences
    Lecturer: Dr. Hila Tishler
    Organizer: Department of Molecular Cell Biology
    Contact: michal.ovadia@weizmann.ac.il

    Special Guest Seminar

    Date:
    12
    Tuesday
    November
    2024
    Lecture / Seminar
    Time: 11:00-12:00
    Title: EV-DNA Drives Anti-Tumor Immunity and Inhibits Metastasis
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Inbal Wortzel
    Organizer: Department of Immunology and Regenerative Biology
    Contact: rony.seger@weizmann.ac.il

    Stromal and Immune Plasticity Shape The Metastatic Microenvironment

    Date:
    07
    Thursday
    November
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Neta Erez
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Precision nanomedicine and bioengineering approaches for cancer therapy

    Date:
    31
    Thursday
    October
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ofra Benny
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: michal.av@weizmann.ac.il
    Details: For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd= ... Read more For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09 Meeting ID: 506 540 2023 Password: 223081
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    EKARD Symposium September 30th 2024

    Date:
    30
    Monday
    September
    2024
    Conference
    Time: 08:30-16:30

    Quantification of nanoscale Extracellular Vesicles by Flow Cytometry: Identifying limits of detection and optimizing instrument settings

    Date:
    16
    Monday
    September
    2024
    Lecture / Seminar
    Time: 09:00-10:00
    Lecturer: Dr. Joshua Welsh
    Organizer: Department of Life Sciences Core Facilities
    Contact: ekaterina.petrovich@weizmann.ac.il
    Details: Special guest webinar, Dr. Joshua Welsh, Staff Scientist, Advanced Technology ... Read more Special guest webinar, Dr. Joshua Welsh, Staff Scientist, Advanced Technology Group, BD Biosciences. Monday, September 16th at 9:00. Title: "Quantification of nanoscale Extracellular Vesicles by Flow Cytometry: Identifying limits of detection and optimizing instrument settings". https://weizmann.zoom.us/j/92912630133?pwd=BcbnawBYcgnRZEzH11Eb2ogLhv6szC.1
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    Targeting mitochondrial pathways in AML– from the clinic to the bench

    Date:
    11
    Wednesday
    September
    2024
    Lecture / Seminar
    Time: 11:00-12:00
    Location: TBD
    Lecturer: Aaron Schimmer, MD, PhD, FRCPC
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: sigal.laor-shoham@weizmann.ac.il

    Cancer Genome Structure and Dynamics

    Date:
    18
    Thursday
    July
    2024
    Conference
    Time: 08:30-17:30
    Location: Dolfi and Lola Ebner Auditorium
    Contact: talias@weizmann.ac.il

    Ubiquitin, cell identity and cancer

    Date:
    11
    Thursday
    July
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Amir Orian MD/PhD
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd= ... Read more For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09 Meeting ID: 506 540 2023 Password: 223081
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    Glioma cellular heterogeneity in time and space

    Date:
    20
    Thursday
    June
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Itay Tirosh
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd= ... Read more For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09 Meeting ID: 506 540 2023 Password: 223081
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    From the lab to the clinic: A toolbox for single-molecule epigenetic analysis of DNA

    Date:
    18
    Tuesday
    June
    2024
    Lecture / Seminar
    Time: 10:00-11:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Prof. Yuval Ebenstein
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Short-read DNA sequencing (NGS) is revolutionizing all fields of biological rese ... Read more Short-read DNA sequencing (NGS) is revolutionizing all fields of biological research. Still, it fails to extract the full range of information associated with genetic material and cannot resolve many variations between genomes. The information content of the genome extends beyond the base sequence in the form of chemical modifications such as DNA methylation, damage lesions, or chromosomal association with DNA-binding proteins (chromatin). For the last decade, our lab has been developing tools for genomic analysis at the single-cell and single-molecule levels. I’ll present a biochemical and physical toolbox for mapping epigenetic modifications in the genome and demonstrate its application in clinical cancer research.
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    Insights from germline and somatic replication repair deficiency on cancer initiation and immunotherapy

    Date:
    06
    Thursday
    June
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Uri Tabori
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd= ... Read more For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09 Meeting ID: 506 540 2023 Password: 223081
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    Machine Learning and Statistics Seminar

    Date:
    05
    Wednesday
    June
    2024
    Lecture / Seminar
    Time: 11:15-12:15
    Title: Harnessing Literature for Boosting Scientific and Clinical Predictive Models
    Location: Jacob Ziskind Building
    Lecturer: Tom Hope
    Organizer: Department of Computer Science and Applied Mathematics
    Contact: karina.avadia@weizmann.ac.il
    Abstract: The explosion of scholarly knowledge presents tremendous opportunities for accel ... Read more The explosion of scholarly knowledge presents tremendous opportunities for accelerating research across the sciences. In this talk, I will present recent work toward helping researchers and clinicians make use of knowledge embedded in the literature. I will focus on methods that use information in the literature for training predictive models and generating scientific hypotheses. This includes models that predict (1) clinical outcomes of hospital patients, (2) new links in biomedical knowledge graphs, and (3) hypotheses in computer science research. Bio: Tom Hope is an assistant professor at The Hebrew University of Jerusalem's School of Computer Science and Engineering, and a research scientist at The Allen Institute for AI (AI2). Tom was awarded the Azrieli Early Career Faculty Fellowship which is given to eight scientists across all fields of study. Prior to that he was a postdoctoral researcher at AI2 and the University of Washington (UW). His work has received four best paper awards, appeared in top AI, NLP and HCI venues, and received coverage from Nature and Science. https://www.cs.huji.ac.il/~tomhope/
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    Lineage tracing in the pancreas reveal the pancreatic ductal adenocarcinoma cell of origin

    Date:
    04
    Tuesday
    June
    2024
    Lecture / Seminar
    Time: 10:00-11:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Dr. Gabriela Koifman
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with a f ... Read more Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with a five-year survival rate of ˜12.5% and is the fourth leading cause of cancer-related death in the western world, estimated to become the second leading cause of cancer related death by the year 2030. PDAC is characterized by a high metastatic burden leading to poor patient outcome. This capability to induce metastatic growth has been ascribed to specific sub-clones within tumours. Intra tumour heterogeneity in PDAC is also exemplified by the coexistence of a tumour hierarchy consisting of phenotypically different sub-populations that harbour unique proliferative, tumourigenic and chemoresistant capacities. Understanding PDAC hierarchies might be a crucial step to identify the cells of origin of PDAC, which will provide an important avenue that will allow deeper understanding of the disease and the development of more effective treatments for PDA patients. Given the ductal morphology of PDAC, ductal cells have for long been the main candidates as tumour initiating cells. However, more recent studies seemed to suggest that PDAC originate from non-ductal, endocrine or acinar cells, transdifferentiating into a ductal-like morphology. Recently, by utilizing commonly used genetic mouse model, we were able to identify a subpopulation of cells within the acinar cell population that is responsible for tumour initiation and serves as the cell of origin of PDAC in this mouse model. we have identified the gene signature of PDAC acinar cell of origin that consist of proliferation and stem cell associated gene signatures. This characterization might lead to the identification of early disease biomarkers and new therapeutic approaches to target the disease and improve the outcome PDAC patients.
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    New STATs on proteasome-mediated tumor inflammation

    Date:
    09
    Thursday
    May
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Yifat Merbl
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd= ... Read more For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09 Meeting ID: 506 540 2023 Password: 223081
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    ABC CHATS - Dr. Irit Carmi-Levy

    Date:
    08
    Wednesday
    May
    2024
    Lecture / Seminar
    Time: 14:00-15:30
    Title: From Bench to Boardroom: My Journey to Leading Personalized Cancer Therapies
    Location: George and Esther Sagan Students' Residence Hall
    Lecturer: Dr. Irit Carmi-Levy
    Contact: reut.magor@weizmann.ac.il
    Details: Dr Irit Carmi-Levy is a drug development expert and an immunologist by training. ... Read more Dr Irit Carmi-Levy is a drug development expert and an immunologist by training. She is currently the General Manager and Chief Scientific Officer at Aummune Ltd, a clinical-stage biotechnology company. Join our ABC CHATS where CEOs share their ABC’s on scientific leadership, breakthroughs and failures throughout their personal stories
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    Abstract: Aummune is a clinical-stage oncology company pioneering a unique approach, coupl ... Read more Aummune is a clinical-stage oncology company pioneering a unique approach, coupling immunotherapy with patient-tailored platform. Our lead molecule—an individualized bispecific T cell engager for solid malignancies— has demonstrated efficacy and safety in several animal models. A Phase 1 study with this asset has successfully completed enrollment and is showing encouraging results.
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    Melanosomes as cancer immune modulators

    Date:
    11
    Thursday
    April
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Carmit Levy
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd= ... Read more For joining remotely please use Zoom: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09 Meeting ID: 506 540 2023 Password: 223081
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    Inheritance of extrachromosomal DNA in cancer cells

    Date:
    09
    Tuesday
    April
    2024
    Lecture / Seminar
    Time: 10:00-11:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Inbar Lifshits
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Details: Inbar Lifshits Dept. of Biomolecular Sciences - WIS
    Abstract: Gene amplification contributing to tumorigenesis and therapy resistance is fre ... Read more Gene amplification contributing to tumorigenesis and therapy resistance is frequently observed across many cancer types. Amplifications of up to 100’s of oncogene DNA copies can be found within chromosomes in homogenous staining regions (HSRs), or in extrachromosomal DNA (ecDNA) elements (also known as double-minutes or DMs). Amplified genes can be oncogenes such as MYCN but they can also be genes that contribute to therapy resistance. For example, amplification of dihydrofolate reductase (DHFR) can lead to methotrexate (MTX) resistance. DMs are acentric and therefore randomly segregate into daughter cells, thereby driving intra-tumor heterogeneity and increasing gene copy number under selection. Although DMs appear to tether to chromosomes during mitosis, the mechanism underlying their inheritance is not clear. Previous works described tethering based on a few observations and in a very limited manner. This work aimed to extensively examine DM tethering at specific mitosis stages. In addition, the effect of anti-cancer therapies, including DNA damaging agent and microtubule drugs was examined. Elucidating the mechanism of DM tethering could provide insight into the inheritance of other acentric DNA molecules, including DNA from viral sources.
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    A guide towards recombinant protein expression

    Date:
    04
    Thursday
    April
    2024
    Lecture / Seminar
    Time: 09:00-10:00
    Title: Fluorescence Labeling of Cancer Cells Using Chemically Modified Bacteria
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Tamar Unger
    Organizer: Department of Life Sciences Core Facilities
    Contact: tamar.unger@weizmann.ac.il

    The roles of RNA processing in cancer initiation and progression and its modulation for cancer therapy

    Date:
    14
    Thursday
    March
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Rotem Karni
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    MICC Conference 2025 "From tumor biology to future clinical solutions"

    Date:
    10
    Sunday
    March
    2024
    -
    12
    Tuesday
    March
    2024
    Conference
    Time: 08:30 - 18:30

    The Clore Center for Biological Physics

    Date:
    03
    Sunday
    March
    2024
    Lecture / Seminar
    Time: 13:15-14:30
    Title: A Statistical Physics Approach to Bacteria under Strong Perturbations
    Location: Nella and Leon Benoziyo Physics Library
    Lecturer: Prof. Nathalie Q. Balaban
    Organizer: Clore Center for Biological Physics
    Contact: debbie.hen@weizmann.ac.il
    Details: refreshments will be served at 12:45
    Abstract: Statistical physics successfully accounts for phenomena involving a large number ... Read more Statistical physics successfully accounts for phenomena involving a large number of components using a probabilistic approach with predictions for collective properties of the system. While biological cells contain a very large number of interacting components, (proteins, RNA molecules, metabolites, etc.), the cellular network is understood as a particular, highly specific, choice of interactions shaped by evolution, and therefore difficultly amenable to a statistical physics description. Here we show that when a cell encounters an acute but non-lethal stress, its perturbed state can be modelled as random network dynamics. Strong perturbations may therefore reveal the dynamics of the underlying network that are amenable to a statistical physics description. We show that our experimental measurements of the recovery dynamics of bacteria from a strong perturbation can be described in the framework of physical aging in disordered systems (Kaplan Y. et al, Nature 2021). Further experiments on gene expression confirm predictions of the model. The predictive description of cells under and after strong perturbations should lead to new ways to fight bacterial infections, as well as the relapse of cancer after treatment.
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    PhD Thesis Defense by Ori Hassin (Prof. Moshe Oren Lab)

    Date:
    18
    Sunday
    February
    2024
    Lecture / Seminar
    Time: 11:30-13:30
    Title: Cell autonomous and non-cell autonomous effects of p53 in colorectal cancer and breast cancer
    Location: Ullmann Building of Life Sciences
    Lecturer: Ori Hassin
    Organizer: Department of Molecular Cell Biology
    Contact: michal.ovadia@weizmann.ac.il

    Nucleo-cytoplasmic shuttling of the 26 proteasome: A potential anti-cancer drug target and prognostic biomarker

    Date:
    15
    Thursday
    February
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Prof. Aaron Ciehanover Ido Livneh
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Special Guest Seminar: Dr. Nir Ben Chetrit

    Date:
    11
    Sunday
    February
    2024
    Lecture / Seminar
    Time: 09:30-10:30
    Title: Empowering a Paradigm Shift: Harnessing Innate Immunity and Tumor Immunization for Immuno-Oncology
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Dr. Nir Ben Chetrit
    Organizer: Department of Molecular Cell Biology
    Contact: michal.ovadia@weizmann.ac.il

    Amino acid substitutants, cancer development, and anti-tumor immunity

    Date:
    01
    Thursday
    February
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Reuven Agami
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZw ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    The interplay of bulky DNA damages, transcription and epigenetics

    Date:
    25
    Thursday
    January
    2024
    Lecture / Seminar
    Time: 15:00-16:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Dr. Sheera Adar
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Details: Host: Pof.Zvi Livneh
    Abstract: DNA damages compromise the ability of the genome to function. Cells from all org ... Read more DNA damages compromise the ability of the genome to function. Cells from all organisms have mechanisms to recognize DNA damage, initiate a signaling response, and recruit repair enzymes. Complete failure of these mechanisms leads to cell death. Incorrect or inefficient repair leads to mutations and cancer. Our work focuses on damages that distort the DNA helix, specifically the carcinogenic dimers induced by ultraviolet (UV) radiation, and the bulky DNA adducts induced by cigarette smoke and by the chemotherapy drug cisplatin. These types of damages are especially deleterious as they block RNA and DNA polymerases. We apply genomic methods to map DNA damages and their repair at high resolution in human genomes. In parallel, we study the effects of damage on gene expression and chromatin accessibility. Both chromatin structure and transcription influence the sensitivity to damage and the efficiency of repair. At the same time, damages elicit changes in chromatin accessibility and a dramatic gene expression shutdown. In my talk, I will give an overview of ongoing research projects in our lab that study the cellular responses to UV-, smoking- and cisplatin-induced damages, and are central to understanding both the carcinogenic process and the mechanisms of chemotherapy resistance.
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    p53: not just a cell-autonomous tumor suppressor

    Date:
    25
    Thursday
    January
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Moshe Oren
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Next-generation antibody-based cancer immunotherapies

    Date:
    11
    Thursday
    January
    2024
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Rony Dahan
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZw ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    LS Luncheon

    Date:
    27
    Wednesday
    December
    2023
    Lecture / Seminar
    Time: 12:00-14:00
    Title: The tumor micro(b)environment and its effects on response to therapy
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Prof. Ravid Straussman
    Organizer: Life Sciences
    Contact: Bracha.Ragen@weizmann.ac.il

    Seminar for PhD thesis defense

    Date:
    06
    Wednesday
    December
    2023
    Lecture / Seminar
    Time: 10:00
    Title: Mutational Analysis and Downregulation of EIF 4 G 2 Protein Expression in Cancer and its Significance in Shaping Patient Outcomes in Endometrial Cancer
    Location: Arthur and Rochelle Belfer Building for Biomedical Research
    Lecturer: Sarit Meril
    Organizer: Department of Molecular Genetics
    Contact: evi.ben-ami@weizmnn.ac.il

    Dissecting the immune-controlled signaling networks driving breast cancer progression

    Date:
    28
    Thursday
    September
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Merav Cohen
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Regulation of the epithelial control gene p63 by oncogenes and the Hippo signaling pathway

    Date:
    14
    Thursday
    September
    2023
    Lecture / Seminar
    Time: 14:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ron M. Prywes
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    The Tumor Suppressors Scribble and Lgl regulators of cell polarity

    Date:
    12
    Tuesday
    September
    2023
    Lecture / Seminar
    Time: 11:00-12:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Maha Abedrabbo
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il

    A HOXB4-initiated and -dependent myeloid leukemia: implications for origin and targeted cure of clonal proliferative disease

    Date:
    16
    Wednesday
    August
    2023
    Lecture / Seminar
    Time: 11:00-12:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Norman Iscove
    Organizer: Department of Immunology and Regenerative Biology
    Contact: michal.av@weizmann.ac.il

    Metastases are just a touch away: Thin membranous connections (TMCs) between tumor cells and macrophages promote tumor cell extravasation

    Date:
    26
    Wednesday
    July
    2023
    Lecture / Seminar
    Time: 11:00-12:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Alessandro Genna
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michalav@weizmann.ac.il

    Microbes in Cancer

    Date:
    17
    Monday
    July
    2023
    Lecture / Seminar
    Time: 11:15-13:00
    Location: Wolfson Building for Biological Research
    Lecturer: Dr. Ilana Livyatan
    Organizer: Life Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Details: Lab of Ravid Straussman, Dept. of Molecular Cell Biology Within the FGS cours ... Read more Lab of Ravid Straussman, Dept. of Molecular Cell Biology Within the FGS course on Translational Cancer Research Host: Zvi Livneh
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    Cancer Imaging in the Clinics

    Date:
    10
    Monday
    July
    2023
    Lecture / Seminar
    Time: 12:15-13:00
    Location: Wolfson Building for Biological Research
    Lecturer: Prof. Dorith Shaham
    Organizer: Life Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Details: This lecture will be preceded by a lecture on “Cancer imaging Principles” ... Read more This lecture will be preceded by a lecture on “Cancer imaging Principles” Host: Zvi Livneh
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    Cancer Imaging Principles

    Date:
    10
    Monday
    July
    2023
    Lecture / Seminar
    Time: 11:15-12:00
    Location: Wolfson Building for Biological Research
    Lecturer: Prof. Rachel Katz-Brull
    Organizer: Life Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Details: Within the FGS course on Translational Cancer Research Host. Zvi Livneh

    Choosing the Right Model for Translational Cancer Research

    Date:
    03
    Monday
    July
    2023
    Lecture / Seminar
    Time: 12:15-13:00
    Location: Wolfson Building for Biological Research
    Lecturer: Dr. Ruth Scherz-Shouval
    Organizer: Weizmann School of Science
    Contact: levana.ayvazo@weizmann.ac.il
    Details: Host: Zvi Livneh

    Liquid Biopsies and Circulating Free DNA in Cancer

    Date:
    03
    Monday
    July
    2023
    Lecture / Seminar
    Time: 11:15-12:00
    Location: Wolfson Building for Biological Research
    Lecturer: Prof. Yuval Dor
    Organizer: Weizmann School of Science
    Contact: levana.ayvazo@weizmann.ac.il
    Details: Host: Zvi Livneh

    Microbiota and cancer treatment - an ecological journey

    Date:
    29
    Thursday
    June
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Ben Boursi
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Localized but not Systemic Type I Interferon Therapy Improves Immune Infiltration and PD-blockade in a Mouse Melanoma Model

    Date:
    27
    Tuesday
    June
    2023
    Lecture / Seminar
    Time: 10:00-11:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Dr. Daniel Harari
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Daniel Harari 1, Ron Rotkopf 2, Shlomit Reich-Zeliger 3, Mathumathi Krishnamohan ... Read more Daniel Harari 1, Ron Rotkopf 2, Shlomit Reich-Zeliger 3, Mathumathi Krishnamohan 1, Alona Dov 1, Vladislav Volchinski 1 and Gideon Schreiber 1 1. Dept. Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel 2. Bioinformatics Unit, The Weizmann Institute of Science 3. Dept. Immunology, The Weizmann Institute of Science Transcriptomic analysis of tumor biopsies from metastatic melanoma patients (SKCM-TCGA) demonstrates a profound survival advantage for approximately one-third of patients who exhibit the highest levels of intratumoral type I Interferon (IFN-I) signaling (Hazard Ratio 0.36; Pr: 4E-06), these which coincide with a sharp increase in transcripts indicating infiltration of CD4-T, CD8-T, B-cells and Macrophages to the tumors. Pathway analysis furthermore demonstrates that these patients exhibit T- and B-cell activation and a Th-1 response. To test if IFN-I signaling is central to and not simply correlating with these associated factors, we employed an adeno-associated virus (AAV) delivery system, locally expressing mouse IFNβ in B16F10 cells grafted into congenic C57BL/6 mice, this a known cold tumor model particularly hard to treat. Whereas anti-PDL1 monotherapy had no response in this model, combination therapy slowed, and in some cases cleared the mice of tumors. AAV-IFNβ monotherapy alone can slow but will not cure the mice. In sharp contrast to localized IFN delivery, systemic IFN therapy showed no beneficial effects in slowing tumor growth. To examine this more deeply, we injected the mice bilaterally with B16F10 tumors, where one tumor received AAV- IFNβ and the contralateral tumor received control. Both the injected and contralateral tumors nevertheless demonstrated a large reduction in tumor size, this effect lost when repeated using IFNAR2 knockout mice. Furthermore both the IFN-treated and contralateral tumors exhibited a large increase in CD3+CD4+ and CD3+CD4- lymphocytes. We submit that enforcing localized IFN-I signaling to a tumor in melanoma can drive immune cell infiltration, with the potential to elicit a systemic immune response, and possibly even cure, particularly when used in combination with immune checkpoint inhibitors.
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    From the lab to cancer therapy – the TOKAD story

    Date:
    26
    Monday
    June
    2023
    Lecture / Seminar
    Time: 12:15-13:00
    Location: Wolfson Building for Biological Research
    Lecturer: Prof. Avigdor Scherz
    Organizer: Weizmann School of Science
    Contact: levana.ayvazo@weizmann.ac.il
    Details: Within the FGS course on Translational Cancer Research Host: Zvi Livneh

    Small Molecule Cancer Chemotherapy

    Date:
    26
    Monday
    June
    2023
    Lecture / Seminar
    Time: 11:15-12:00
    Location: Wolfson Building for Biological Research
    Lecturer: Prof. Nir London
    Organizer: Weizmann School of Science
    Contact: levana.ayvazo@weizmann.ac.il
    Details: Within the FGS course on Translational Cancer Research Host: Zvi Livneh

    Tumor intrinsic immunity: Mismatch repair deficiency as a model

    Date:
    25
    Sunday
    June
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Luis A. Diaz, M.D.
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Beyond Darwin: understanding cancer persister cells

    Date:
    22
    Thursday
    June
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Yaara Oren
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Immunotherapy in Cancer Translation Research

    Date:
    19
    Monday
    June
    2023
    Lecture / Seminar
    Time: 11:15
    Location: Wolfson Building for Biological Research
    Lecturer: Prof. Ziv Shulman
    Organizer: Weizmann School of Science
    Contact: levana.ayvazo@weizmann.ac.il
    Details: Within the FGS course on Translational Cancer Research Host: Zvi Livneh

    Drivers and dependencies arising during tumor evolution

    Date:
    06
    Tuesday
    June
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Kris Wood
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    PhD Thesis Defense by Omer Goldman (Ayelet Erez Lab)

    Date:
    21
    Sunday
    May
    2023
    Lecture / Seminar
    Time: 13:00
    Title: Non-liver cancers rewire liver metabolism in the host
    Location: Max and Lillian Candiotty Building
    Lecturer: Omer Goldman (Ayelet Erez Lab)
    Organizer: Department of Molecular Cell Biology
    Contact: michal.ovadia@weizmann.ac.il

    Next-generation transcriptomics-based precision oncology

    Date:
    14
    Sunday
    May
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Eytan Ruppin, CDSL, NCI, NIH
    Organizer: Department of Immunology and Regenerative Biology
    Contact: michal.av@weizmann.ac.il

    Innovations in Interventional Oncology: From Benchtop to Clinic

    Date:
    11
    Thursday
    May
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Stephen Solomon
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    The mitochondrial gatekeeper VDAC1 as an emerging drug target for novel anti-cancer therapeutics

    Date:
    04
    Thursday
    May
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Varda Shoshan-Barmatz
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Conspiring with the Enemy: A Unique Mechanism in Class A JDPs Stabilizes Oncogenic p53 Mutants

    Date:
    02
    Tuesday
    May
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Gerhard M.J. Schmidt Lecture Hall
    Lecturer: Guy Zoltsman
    Organizer: Department of Chemical and Structural Biology
    Contact: nicole.dorfman@weizmann.ac.il

    Drug delivery systems in the treatment of cancer: Fundamentals and clinical applications

    Date:
    20
    Thursday
    April
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Avi Schroeder
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Turning immune “cold” into immune “hot” tumors by reverting the tumor microenvironment into hostile to the cancer cells.

    Date:
    30
    Thursday
    March
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Avigdor Scherz
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Autotaxin in the tumor microenvironment: from discovery to metastasis and immune evasion

    Date:
    23
    Thursday
    March
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Wouter Moolenaar
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Reprogramming Macrophages using Early Apoptotic Cellular Therapy Against Peritoneal Solid Tumor

    Date:
    16
    Thursday
    March
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Dror Mevorach
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Circulating tumor cells

    Date:
    08
    Wednesday
    March
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Prof. Nicola Aceto
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Soft Matter and Biomaterials Seminar

    Date:
    19
    Sunday
    February
    2023
    Lecture / Seminar
    Time: 11:00-12:00
    Title: Nanotechnology for targeted drug and gene delivery: from basics to clinical applications
    Location: Perlman Chemical Sciences Building
    Lecturer: Prof. Avi Schroeder
    Organizer: Department of Molecular Chemistry and Materials Science
    Contact: ananaamat@gmail.com
    Abstract: Medicine is taking its first steps toward patient-specific cancer care. Nanopart ... Read more Medicine is taking its first steps toward patient-specific cancer care. Nanoparticles have many potential benefits for treating cancer, including the ability to transport complex molecular cargoes, including siRNA and protein, as well as targeting specific cell populations. The talk will explain the fundamentals of nanotechnology, from ‘barcoded nanoparticles’ that target sites of cancer where they perform a programmed therapeutic task. Specifically, liposomes diagnose the tumor and metastasis for their sensitivity to different medications, providing patient-specific drug activity information that can be used to improve the medication choice. The talk will also describe how liposomes can be used for degrading the pancreatic stroma to allow subsequent drug penetration into pancreatic adenocarcinoma and how nanoparticle’ biodistribution and anti-cancer efficacy are impacted by the patient’s sex and, more specifically, the menstrual cycle. The evolution of drug delivery systems into synthetic cells, programmed nanoparticles that have an autonomous capacity to synthesize diagnostic and therapeutic proteins inside the body, and their promise for treating cancer and immunotherapy, will be discussed. References: 1) Theranostic barcoded nanoparticles for personalized cancer medicine, Yaari et al. Nature Communications, 2016, 7, 13325 2) Collagenase nanoparticles enhance the penetration of drugs into pancreatic tumors, Zinger et al., ACS Nano, 13 (10), 11008-11021, 2019 3) Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases, Science Advances, Kaduri et al., 7 (41), eabj5435, 2021 4) Nanoparticles accumulate in the female reproductive system during ovulation affecting cancer treatment and fertility, Poley et al., ACS nano, 2022
    Close abstract

    Sensitizing P-selectin-expressing brain malignancies to immune checkpoint modulators

    Date:
    16
    Thursday
    February
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ronit Satchi-Fainaro, PhD
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Genetic and Epigenetic Drivers of Melanoma Formation and Progression

    Date:
    09
    Thursday
    February
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Marcus Bosenberg, MD, PhD
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    MAPPING PATHS OF TUMOR EVOLUTION WITH SINGLE-CELL PHYLOGENETICS

    Date:
    26
    Thursday
    January
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Nir Yosef
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Andrei Gudkov- Special Guest Lecture

    Date:
    17
    Tuesday
    January
    2023
    Lecture / Seminar
    Time: 11:30-12:30
    Location: Ullmann Building of Life Sciences
    Lecturer: Sigal Laor-Shoham
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: sigal.laor-shoham@weizmann.ac.il

    Non-coding RNAs as determinants of breast cancer progression

    Date:
    12
    Thursday
    January
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Giovanni Blandino
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    SERGIO LOMBROSO AWARD IN CANCER RESEARCH CEREMONY AND SYMPOSIUM

    Date:
    09
    Monday
    January
    2023
    Conference
    Time: 08:00
    Location: Dolfi and Lola Ebner Auditorium
    Contact: moshe.oren@weizmann.ac.il

    Public MSc thesis defense

    Date:
    02
    Monday
    January
    2023
    Lecture / Seminar
    Time: 10:00-11:00
    Title: Impaired Translation Fidelity Induces Aberrant Peptide Presentation In Melanoma
    Location: Ullmann Building of Life Sciences
    Lecturer: Chen Weller
    Organizer: Department of Molecular Cell Biology
    Contact: yael.lepek@weizmann.ac.il

    WIS-MD Anderson Symposium in cancer research 2022

    Date:
    12
    Monday
    September
    2022
    -
    13
    Tuesday
    September
    2022
    Conference
    Time: 09:00 - 16:00

    Tannor award 2022

    Date:
    23
    Saturday
    July
    2022
    Conference
    Time: 11:00-13:00