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All upcoming events

Turning immune “cold” into immune “hot” tumors by reverting the tumor microenvironment into hostile to the cancer cells.

Date:
30
Thursday
March
2023
Lecture / Seminar
Time: 14:00-15:00
Location: Max and Lillian Candiotty Building
Lecturer: Prof. Avigdor Scherz
Organizer: Dwek Institute for Cancer Therapy Research
Contact: michal.av@weizmann.ac.il
Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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Drug delivery systems in the treatment of cancer: Fundamentals and clinical applications

Date:
20
Thursday
April
2023
Lecture / Seminar
Time: 14:00-15:00
Location: Max and Lillian Candiotty Building
Lecturer: Dr. Avi Schroeder
Organizer: Dwek Institute for Cancer Therapy Research
Contact: michal.av@weizmann.ac.il
Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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Beyond Darwin: understanding cancer persister cells

Date:
22
Thursday
June
2023
Lecture / Seminar
Time: 14:00-15:00
Location: Max and Lillian Candiotty Building
Lecturer: Dr. Yaara Oren
Organizer: Dwek Institute for Cancer Therapy Research
Contact: michal.av@weizmann.ac.il
Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Past

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    All Events

    Autotaxin in the tumor microenvironment: from discovery to metastasis and immune evasion

    Date:
    23
    Thursday
    March
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Wouter Moolenaar
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Reprogramming Macrophages using Early Apoptotic Cellular Therapy Against Peritoneal Solid Tumor

    Date:
    16
    Thursday
    March
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Dror Mevorach
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Circulating tumor cells

    Date:
    08
    Wednesday
    March
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Prof. Nicola Aceto
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Soft Matter and Biomaterials Seminar

    Date:
    19
    Sunday
    February
    2023
    Lecture / Seminar
    Time: 11:00-12:00
    Title: Nanotechnology for targeted drug and gene delivery: from basics to clinical applications
    Location: Perlman Chemical Sciences Building
    Lecturer: Prof. Avi Schroeder
    Organizer: Department of Molecular Chemistry and Materials Science
    Contact: ananaamat@gmail.com
    Abstract: Medicine is taking its first steps toward patient-specific cancer care. Nanopart ... Read more Medicine is taking its first steps toward patient-specific cancer care. Nanoparticles have many potential benefits for treating cancer, including the ability to transport complex molecular cargoes, including siRNA and protein, as well as targeting specific cell populations. The talk will explain the fundamentals of nanotechnology, from ‘barcoded nanoparticles’ that target sites of cancer where they perform a programmed therapeutic task. Specifically, liposomes diagnose the tumor and metastasis for their sensitivity to different medications, providing patient-specific drug activity information that can be used to improve the medication choice. The talk will also describe how liposomes can be used for degrading the pancreatic stroma to allow subsequent drug penetration into pancreatic adenocarcinoma and how nanoparticle’ biodistribution and anti-cancer efficacy are impacted by the patient’s sex and, more specifically, the menstrual cycle. The evolution of drug delivery systems into synthetic cells, programmed nanoparticles that have an autonomous capacity to synthesize diagnostic and therapeutic proteins inside the body, and their promise for treating cancer and immunotherapy, will be discussed. References: 1) Theranostic barcoded nanoparticles for personalized cancer medicine, Yaari et al. Nature Communications, 2016, 7, 13325 2) Collagenase nanoparticles enhance the penetration of drugs into pancreatic tumors, Zinger et al., ACS Nano, 13 (10), 11008-11021, 2019 3) Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases, Science Advances, Kaduri et al., 7 (41), eabj5435, 2021 4) Nanoparticles accumulate in the female reproductive system during ovulation affecting cancer treatment and fertility, Poley et al., ACS nano, 2022
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    Sensitizing P-selectin-expressing brain malignancies to immune checkpoint modulators

    Date:
    16
    Thursday
    February
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ronit Satchi-Fainaro, PhD
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Genetic and Epigenetic Drivers of Melanoma Formation and Progression

    Date:
    09
    Thursday
    February
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Marcus Bosenberg, MD, PhD
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    MAPPING PATHS OF TUMOR EVOLUTION WITH SINGLE-CELL PHYLOGENETICS

    Date:
    26
    Thursday
    January
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Nir Yosef
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Andrei Gudkov- Special Guest Lecture

    Date:
    17
    Tuesday
    January
    2023
    Lecture / Seminar
    Time: 11:30-12:30
    Location: Ullmann Building of Life Sciences
    Lecturer: Sigal Laor-Shoham
    Organizer: Moross Integrated Cancer Center (MICC)
    Contact: sigal.laor-shoham@weizmann.ac.il

    Non-coding RNAs as determinants of breast cancer progression

    Date:
    12
    Thursday
    January
    2023
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Giovanni Blandino
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    SERGIO LOMBROSO AWARD IN CANCER RESEARCH CEREMONY AND SYMPOSIUM

    Date:
    09
    Monday
    January
    2023
    Conference
    Time: 08:00
    Location: Dolfi and Lola Ebner Auditorium
    Contact: moshe.oren@weizmann.ac.il

    Public MSc thesis defense

    Date:
    02
    Monday
    January
    2023
    Lecture / Seminar
    Time: 10:00-11:00
    Title: Impaired Translation Fidelity Induces Aberrant Peptide Presentation In Melanoma
    Location: Ullmann Building of Life Sciences
    Lecturer: Chen Weller
    Organizer: Department of Molecular Cell Biology
    Contact: yael.lepek@weizmann.ac.il

    Computational approaches for identifying genomic and metabolic predictors of cancer patient response to immune checkpoint blockade therapy

    Date:
    29
    Thursday
    December
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Keren Yizhak
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    RNA-Lipid Nanoparticles 2.0: From Gene Silencing to Genome Editing

    Date:
    25
    Sunday
    December
    2022
    Lecture / Seminar
    Time: 11:00-12:00
    Location: Perlman Chemical Sciences Building
    Lecturer: Prof. Dan Peer
    Organizer: Department of Molecular Chemistry and Materials Science
    Contact: ana.naamat@weizmann.ac.il
    Abstract: Accumulating work points out relevant genes and signaling pathways hampered in h ... Read more Accumulating work points out relevant genes and signaling pathways hampered in human disorders as potential candidates for therapeutics. Developing nucleic acid-based tools to manipulate gene expression, such as siRNAs, mRNA and genome editing strategies, open up opportunities for personalized medicine. Yet, although major progress was achieved in developing RNA targeted delivery carriers, mainly by utilizing monoclonal antibodies (mAbs) for targeting, their clinical translation has not occurred. In part because of massive development and production requirements and high batch-to-batch variability of current technologies, which relies on chemical conjugation. Here we present a self-assembled modular platform that enables to construct theoretically unlimited repertoire of RNA targeted carriers. The platform self-assembly is based on a membrane-anchored lipoprotein, incorporated into RNA-loaded novel, unique lipid nanoparticles that interact with the antibody Fc domain. We show that a simple switch of 8 different mAbs, redirects specific uptake of siRNAs by diverse leukocyte subsets in vivo. The platform therapeutic potential is demonstrated in an inflammatory bowel disease model, by targeting colon macrophages to reduce inflammatory symptoms, and in Mantle Cell Lymphoma xenograft model, by targeting cancer cells to induce cell death and improve survival. In addition, I will discuss novel approach for delivering modified mRNA to specific cell types in vivo utilizing this platform. I will also share some data on mRNA vaccines for COVID19 and Finally, I will share new data showing very high efficiency genome editing in glioma and metastatic ovarian cancer. This modular delivery platform can serve as a milestone in turning precision medicine feasible.
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    A direct MS approach for identifying damaged DNA in cancerous cells

    Date:
    20
    Tuesday
    December
    2022
    Lecture / Seminar
    Time: 10:00-11:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Joanna Stimpson
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: DNA can be damaged by chemicals in our surroundings, and occurs at the nucleophi ... Read more DNA can be damaged by chemicals in our surroundings, and occurs at the nucleophilic sites on the strand. Of particular interest is alkylation at the O6-position of guanine, which goes on to cause G:C -> A:T mutations. These mutations cause genomic instability and are linked to the onset of colorectal cancer (CRC). Identifying the extent and diversity of O6-guanine alkylation informs us on the exposure cancer patients have undergone. Here we have developed a mass spectrometry based approached to identify damaged DNA. The method is based on the DNA repair protein MGMT, which directly removes alkylation from O6-alkyl guanine. MGMT can be used to probe the type and extent of O6-alkylation.
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    Engineering Imaging Technologies and Discovering Biomarkers to Characterize Disease States

    Date:
    14
    Wednesday
    December
    2022
    Lecture / Seminar
    Time: 11:00-12:00
    Location: Gerhard M.J. Schmidt Lecture Hall
    Lecturer: Prof. Barbara S. Smith
    Organizer: Department of Molecular Chemistry and Materials Science
    Contact: natali.levin@weizmann.ac.il
    Details:
    Abstract: Neurodegenerative diseases are often clinically, genetically, and pathologically ... Read more Neurodegenerative diseases are often clinically, genetically, and pathologically heterogeneous. The clinical impact of understanding heterogeneity is perhaps best observed in cancer, where subtype-specificity within diagnoses, prognoses, and treatments have had a critical impact on clinical decision making and patient outcomes. A better understanding of how mechanisms are related to or drive heterogeneity within diseases such as Amyotrophic Lateral Sclerosis (ALS), will have a direct impact on patient outcomes, with a conscious effort to move towards precision medicine and targeted therapeutics for patients, which are urgently needed. For this reason, neuroscientists and oncologists have long aspired to achieve an understanding of the mechanisms governing pathophysiology. Our interdisciplinary work integrates technologies across a wide range of fields to surpass the current barriers in understanding disease pathophysiology. This talk will highlight a series of optical and photoacoustic imaging tools as well as multi-omics analysis that have been developed and studied in Dr. Smith’s lab to address the urgent need for non-invasive cancer detection and the characterization of neurological disorders. Through this work, we aim to develop translational technologies and methodologies to better characterize, understand, and detect disease pathogenesis, beyond current capabilities.
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    Using genomics to investigate radiation-related thyroid cancer following the Chernobyl accident in 1986

    Date:
    13
    Tuesday
    December
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Stephen J. Chanock, M.D.
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    2nd Israeli Flow Cytometry conference

    Date:
    04
    Sunday
    December
    2022
    -
    05
    Monday
    December
    2022
    Conference
    Time: 08:00
    Location: The David Lopatie Conference Centre
    Contact: ziv.porat@weizmann.ac.il
    2nd Israeli Flow Cytometry conference Conference website

    Focus on Cancer Early Detection Research

    Date:
    21
    Monday
    November
    2022
    Conference
    Time: 08:00
    Location: Wolfson Building for Biological Research
    Contact: zvi.livneh@weizmann.ac.il
    Focus on Cancer Early Detection Research Conference website

    Reprograming T cell immunity to enhance immunotherapy: from protein engineering to bedside

    Date:
    17
    Thursday
    November
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Cyrille Cohen
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Microbiome Therapeutics to Enhance Anti-Cancer Immunity

    Date:
    09
    Wednesday
    November
    2022
    Lecture / Seminar
    Time: 11:00-12:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Sin-Hyeog IM
    Organizer: Department of Immunology and Regenerative Biology
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Host pro-tumorigenic response to anti-cancer therapies: the role of the ECM

    Date:
    03
    Thursday
    November
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Yuval Shaked
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Interferon signaling is associated with chemoresistance in triple-negative breast cancer

    Date:
    22
    Thursday
    September
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Stefan Wiemann
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Immunology and Regenerative Biology Colloquium

    Date:
    15
    Thursday
    September
    2022
    Lecture / Seminar
    Time: 11:00-12:00
    Title: Stem Cells: Coping with Stress
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Prof. Elaine Fuchs
    Organizer: Department of Immunology and Regenerative Biology
    Contact: lili.kasumov@weizmann.ac.il
    Abstract: Using mammalian skin as a model, Prof. Elaine Fuchs studies the remarkable prope ... Read more Using mammalian skin as a model, Prof. Elaine Fuchs studies the remarkable properties of tissue stem cells to replenish dying cells and repair wounds, and how the cells know which tasks to perform and when. She explores how stem cells sense and communicate with other cells in their environment. Aiming at advancing therapeutics, she dissects how communication networks malfunction in inflammation, aging, and cancers.
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    WIS-MD Anderson Symposium in cancer research 2022

    Date:
    12
    Monday
    September
    2022
    -
    13
    Tuesday
    September
    2022
    Conference
    Time: 09:00 - 16:00

    Memory NK cells in Cancer Immunotherapy

    Date:
    08
    Thursday
    September
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Inpyo Choi
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Zoom PhD Thesis Defense - Saptaparna Mukherjee

    Date:
    01
    Monday
    August
    2022
    Lecture / Seminar
    Time: 12:00-14:00
    Title: Understanding the Impact of p53 Mutations by Interrogating its Protein Interacting Network
    Lecturer: Saptaparna Mukherjee (Prof. Moshe Oren Lab)
    Organizer: Department of Molecular Cell Biology
    Contact: michal.ovadia@weizmann.ac.il
    Details: Zoom Link: https://weizmann.zoom.us/j/98889132347?pwd=Wnd3SlBGRk1IZXV0SFBwT1Fh ... Read more Zoom Link: https://weizmann.zoom.us/j/98889132347?pwd=Wnd3SlBGRk1IZXV0SFBwT1FhY1Zkdz09 Meeting ID: 988 8913 2347 Password: 071647
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    Gallery: Zoom PhD Thesis Defense - Saptaparna Mukherjee Gallery
    Zoom PhD Thesis Defense - Saptaparna Mukherjee Lecture / Seminar website

    Single-molecule and single-cell epigenetics: Decoding the epigenome for cancer research and diagnostics

    Date:
    28
    Thursday
    July
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Efrat Shema
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Next-generation transcriptomics-based precision oncology

    Date:
    25
    Monday
    July
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Eytan Ruppin
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Tannor award 2022

    Date:
    23
    Saturday
    July
    2022
    Conference
    Time: 11:00-13:00

    Special guest semianr with Dr. Asaf Zviran

    Date:
    17
    Sunday
    July
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Title: Ultra-sensitive detection and monitoring of solid cancers using whole-genome mutation integration
    Location: Arthur and Rochelle Belfer Building for Biomedical Research
    Lecturer: Dr. Asaf Zviran
    Organizer: Azrieli Institute for Systems Biology
    Contact: sandra.britton@weizmann.ac.il
    Abstract: Early detection of recurrence and monitoring of Molecular Residual Disease (MRD) ... Read more Early detection of recurrence and monitoring of Molecular Residual Disease (MRD) post-surgery is critical for clinical decision-making to tailor personalized treatments across solid cancers. C2i Genomics has developed an ultra-sensitive whole-genome ctDNA test, allowing extremely accurate and sensitive monitoring of patients with solid tumors. Here we present results from applying whole-genome sequencing (WGS) and identification of ctDNA across a variety of adult and pediatric solid tumors. We integrate a genome-wide mutation and copy number monitoring approach coupled with advanced signal processing and Artificial Intelligence (AI) for measuring the tumor load from low-input blood samples (~1mL of plasma) with ultra-sensitive detection. The increased sensitivity allowed clinical detection of tumor fraction down to 5*10-5 and recurrence detection sensitivity achieving >65% at the first two months after definitive treatment, enabling earlier clinical intervention for high-risk patients.
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    The Tumor Ecosystem – Evolution of a Concept

    Date:
    14
    Thursday
    July
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Isaac P. Witz
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    Cellular Plasticity in Cancer

    Date:
    05
    Tuesday
    July
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Dana Pe’er
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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    What you always wanted to know about nanoparticles, proteins and biomaterials, but never dared to ask

    Date:
    30
    Thursday
    June
    2022
    Lecture / Seminar
    Time: 11:00-12:00
    Location: Gerhard M.J. Schmidt Lecture Hall
    Lecturer: Prof. Dr. Klaus D. Jandt
    Organizer: Department of Molecular Chemistry and Materials Science
    Contact: ana.naamat@weizmann.ac.il
    Abstract: This lecture presents an overview on major research work of the Fellow’s group ... Read more This lecture presents an overview on major research work of the Fellow’s group in the areas of polymer nanoparticles for drug delivery, control of protein adsorption on materials surfaces and protein nanofibers. In addition, the new excellence graduate school (Research Training Group) RTG 2723: Materials‐Microbe‐Microenvironments: Antimicrobial biomaterials with tailored structures and properties (M‐M‐M) funded by the German Science Foundation will be introduced. Polymer nanoparticles (PNP) became recently exceedingly popular through novel vaccination technologies but have also major potential for fighting inflammation and cancer. These drug release properties of the PNP depend on their structure. Yet, the literature reports little about the structure and the properties of most PNPs, except the chemical composition. The PNP’s crystallinity, thermal and mechanical properties are frequently ignored, even though they may play a key role in the drug delivery properties of the PNPs. Protein adsorption on biomaterials is the first process after implantation and determines much of the fate of the biomaterial, such as cell adhesion, blood coagulation or infection at the implant site. Despite decades of research, only rules of thumb exist to predict protein adsorption behavior. We present nanotechnological approaches to control protein adsorption using nanostructured semicrystalline polymers and crystal facets of TiO2. Selfassembled protein nanofibers consisting of one or more proteins, potentially allow to tailor the properties of biomaterials interfaces and to create bone mimetic structures. Finally, the new DFG‐RTG 2723: Materials‐Microbe‐Microenvironments: Antimicrobial biomaterials with tailored structures and properties (M‐M‐M) in Jena will be introduced. The aim of the RTG is to provide excellent training for approximately 40 international doctoral researchers in antimicrobial biomaterials in interdisciplinary tandem projects, connecting materials science and medical science. The RTG pursues a new strategy by developing antibiotic free biomaterials, where the antimicrobial action is based mainly on physical principles. The new RTG offers ample opportunity for fruitful cooperation and exchange with leading research institutions in Israel.
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    Mechanisms driving genome catastrophes in cancer

    Date:
    22
    Wednesday
    June
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ofer Shoshani
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    Mechanisms of cancer protection in congenital IGF1 deficiencies

    Date:
    09
    Thursday
    June
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Haim Werner
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Therapies targeting EGFR and PD-L1 in lung cancer

    Date:
    09
    Thursday
    June
    2022
    Lecture / Seminar
    Time: 09:00-10:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Yosef Yarden
    Organizer: Department of Life Sciences Core Facilities
    Contact: Orith.Leitner@weizmann.ac.il
    Details: Host: Dr. Orith Leitner, Antibody unit

    On discovery and sensitivity in (photo)catalysis

    Date:
    07
    Tuesday
    June
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Gerhard M.J. Schmidt Lecture Hall
    Lecturer: Prof. Frank Glorius
    Organizer: Department of Molecular Chemistry and Materials Science
    Contact: natali.levin@weizmann.ac.il
    Abstract: Catalysis is a key technology, since it allows for increased levels of selectivi ... Read more Catalysis is a key technology, since it allows for increased levels of selectivity and efficacy of chemical transformations. While significant progress can be made by rational design or engineered step-by-step improvements, many pressing challenges in the field require the discovery of new and formerly unexpected results. Arguably, the question “How to discover?” is at the heart of the scientific process. In this talk, (smart) screening strategies for accelerated discovery and improved reproducibility will be presented, together with new photocatalytic transformations. In addition, two other exciting areas will be addressed: N-heterocyclic carbenes (NHCs) are powerful ligands in catalysis due to their strong electron-donating properties and their ability to form very stable bonds to transition metals. In addition, they can stabilize and modify nanoparticles or flat metals surfaces, outperforming established phosphine or thiol ligands regarding structural flexibility, electron-donating properties and stability. Current research is highly interdisciplinary and focusses on the basic understanding of the binding mode, mobility and the elucidation of the impact on the surface properties. Exciting applications in materials science, heterogeneous catalysts and beyond are within reach. Biological membranes and their constituents are some of the most important and fundamental building blocks of life. However, their exact role in many essential cellular processes as well as in the development of diseases such as cancer or Alzheimer's is still not very well understood. Thus, we design, synthesize and evaluate imidazolium-based lipid analogs that can integrate into biological membranes and can be used as probes for live cell imaging or to manipulate membranes.
    Close abstract

    Metabolism, diet, and cancer

    Date:
    31
    Tuesday
    May
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Joshua Rabinowitz, MD, PhD
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    Targeting metabolic vulnerabilities in cancer

    Date:
    26
    Thursday
    May
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Tomer Shlomi
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    BRD4 in Transcription Programming and Cancer Therapy

    Date:
    26
    Thursday
    May
    2022
    Lecture / Seminar
    Time: 10:30-11:30
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Prof. Cheng-Ming Chiang
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Bromodomain-containing protein 4 (BRD4) is an epigenetic regulator and transcrip ... Read more Bromodomain-containing protein 4 (BRD4) is an epigenetic regulator and transcription cofactor whose phosphorylation by casein kinase II (CK2) and dephosphorylation by protein phosphatase 2A (PP2A) modulates its function in gene-specific targeting and recruitment of transcriptional regulators and chromatin modifiers. BRD4 has emerged as an important cancer therapeutic target due to widely available small compound inhibitors, such as JQ1 and I-BET, targeting the bromodomain and extra-terminal (BET) family members. Besides transcriptional regulation, BRD4 also plays crucial roles in regulating diverse cellular processes, including cell cycle progression, DNA damage response, chromatin structure maintenance, stem cell reprogramming, cell lineage differentiation, and viral latency and reactivation. While BET inhibitors and degraders show promising anticancer effects, issues related to drug resistance upon prolonged treatment remain a challenge in BET-targeted therapeutics development. Recently, we identified specific small compound inhibitors targeting phosphorylation-dependent BRD4 interaction with distinct transcription/replication components and DNA damage response (DDR) factors, including p53, c-Myc, AP-1, and cancer-associated human papillomavirus E2 proteins. Some of these compounds effectively block cancer cell growth and migration and specifically inhibit p53 interaction with BRD4. These new types of protein-protein interaction (PPI) inhibitors highlight molecular action distinct from the widely used BET bromodomain inhibitors.
    Close abstract

    18th International p53 Workshop

    Date:
    22
    Sunday
    May
    2022
    -
    26
    Thursday
    May
    2022
    Conference
    Time: 08:00
    Location: Michael Sela Adutitorium
    Contact: varda.rotter@weizmann.ac.il
    18th International p53 Workshop Conference website

    Killing Cancer Stem Cells

    Date:
    28
    Thursday
    April
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Jeremy Rich, MD, MHS, MBA
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    Killing Cancer Stem Cells

    Date:
    28
    Thursday
    April
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Prof. Jeremy N. Rich, MD, MHS, MBA
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Insights on hypermutation in cancer initiation and response to immunotherapy. Lessons from a rare cancer syndrome

    Date:
    10
    Sunday
    April
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Uri Tabori
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    The microbiome as part of the tumor ecosystem

    Date:
    07
    Thursday
    April
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ravid Straussman and Lian Narunsky Haziza
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    Tissue level insights from cellular measurements – Identifying multi-cellular hubs in colorectal cancer

    Date:
    06
    Wednesday
    April
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Matan Hofree
    Organizer: Department of Immunology and Regenerative Biology
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    Tissue level insights from cellular measurements – Identifying multi-cellular hubs in colorectal cancer

    Date:
    06
    Wednesday
    April
    2022
    Lecture / Seminar
    Time: 00:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Matan Hofree
    Organizer: Department of Immunology and Regenerative Biology
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    From Basic Cancer Research to Innovative Therapies

    Date:
    28
    Monday
    March
    2022
    -
    30
    Wednesday
    March
    2022
    Conference
    Time: 08:00
    Location: Michael Sela Adutitorium
    Contact: sigalla@weizmann.ac.il
    Gallery: From Basic Cancer Research to Innovative Therapies Gallery
    From Basic Cancer Research to Innovative Therapies Conference website

    PhD defense seminar by Lian Narunsky Haziza (Ravid Straussman lab)

    Date:
    21
    Monday
    March
    2022
    Lecture / Seminar
    Time: 14:00-15:30
    Title: Pan-cancer analyses of the tumor mycobiome and its clinical effects
    Lecturer: Lian Narunsky Haziza
    Organizer: Department of Molecular Cell Biology
    Contact: yael.lepek@weizmann.ac.il
    Details:
    Gallery: PhD defense seminar by Lian Narunsky Haziza (Ravid Straussman lab) Gallery
    PhD defense seminar by Lian Narunsky Haziza (Ravid Straussman lab) Lecture / Seminar website

    Canceled ! - The microbiome as part of the tumor ecosystem

    Date:
    10
    Thursday
    March
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ravid Straussman and Lian Narunsky Haziza
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZ ... Read more Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
    Close details

    Tumor ecosystems- from prediction to modelling.

    Date:
    15
    Tuesday
    February
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Carlos Caldas
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Skin stem cells in tissue regeneration and tumor formation

    Date:
    03
    Thursday
    February
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Yaron Fuchs
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Cancer is a disease of epigenetic stochasticity

    Date:
    27
    Thursday
    January
    2022
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Andrew(Andy) Feinberg
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Current Technologies in Cell Analysis and Sorting by Flow Cytometry

    Date:
    06
    Thursday
    January
    2022
    Lecture / Seminar
    Time: 09:00-10:00
    Location: ZOOM
    Lecturer: Dr. Ekaterina Kopitman
    Organizer: Department of Life Sciences Core Facilities
    Contact: Ekaterina.Petrovich@weizmann.ac.il
    Gallery: Current Technologies in Cell Analysis and Sorting by Flow Cytometry Gallery
    Current Technologies in Cell Analysis and Sorting by Flow Cytometry Lecture / Seminar website

    PhD Thesis Defense - The non-cell autonomous roles of TAZ and YAP in breast cancer

    Date:
    02
    Sunday
    January
    2022
    Lecture / Seminar
    Time: 09:00-11:00
    Location: Ullmann Building of Life Sciences
    Lecturer: Anat Gershoni (Moshe Oren Lab)
    Organizer: Department of Molecular Cell Biology
    Contact: michal.ovadia@weizmann.ac.il

    Dissecting tumor heterogeneity in glioma

    Date:
    30
    Thursday
    December
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Itay Tirosh
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    At the crossroads of science, engineering, and medicine: Improving cancer diagnosis

    Date:
    23
    Thursday
    December
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Yonina Eldar & Keren Peri-Hanania, MD
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    From cell circuits to collective cell behaviour

    Date:
    20
    Monday
    December
    2021
    Colloquium
    Time: 11:00-12:15
    Location: Gerhard M.J. Schmidt Lecture Hall
    Lecturer: Prof. Leah Edelstein-Keshet
    Organizer: Faculty of Chemistry
    Contact: sarah.amzallag@weizmann.ac.il
    Abstract: In order for our body to heal and repair injury, cell sheets must move together ... Read more In order for our body to heal and repair injury, cell sheets must move together to seal a gap. To overcome infection, white blood cells need to track down and destroy pathogens. Such processes can only work if cells can "sense" their environment and "decide" to move in the right direction, or else, to coordinate with neighbouring cells. This requires tight control of adhesion between cells, as well as the speed and direction of cell migration. In this talk, I will describe mathematical and computational research on cell migration, both in normal and abnormal (cancer) cells. I will focus mainly on recent "multi-scale" modeling, where we combine our understanding of the "molecular machinery" inside cells, with information about how cells interact with one another. We use this approach to investigate the behaviour of groups of cells. Combining mathematics and computational methods, we can get some insights on cell organization in development and in wound healing, as well as what could go wrong in disease such as cancer.
    Close abstract
    Gallery: From cell circuits to collective cell behaviour Gallery
    From cell circuits to collective cell behaviour Colloquium website

    Antibody-mediated immune responses in ovarian cancer patients

    Date:
    09
    Thursday
    December
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ziv Shulman
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    The epigenetic landscape of cancer-associated fibroblasts

    Date:
    30
    Tuesday
    November
    2021
    Lecture / Seminar
    Time: 10:00-10:30
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Coral Halperin
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Cancer cells recruit and rewire normal cells in their microenvironment to suppor ... Read more Cancer cells recruit and rewire normal cells in their microenvironment to support and protect them by creating a pro-tumorigenic tumor microenvironment (TME). We lack an overarching view of how, despite being genomically stable, stromal cells in the tumor microenvironment are heterogeneously reprogrammed across time and space to promote the evolution of aggressive disease. Recent work by us and others has shown that fibroblasts in the tumor microenvironment are transcriptionally rewired to become protumorigenic cancer associated fibroblasts (CAFs). Here we hypothesize that CAFs are epigenetically modified and that these modifications lead to deregulation of signaling pathways and transcriptional circuitries that support tumorigenic growth in the neoplastic cells. We applied a sensitive method of whole genome bisulfide sequencing on a model of triple-negative breast cancer in mice to evaluate the methylome profile of CAFs compared to normal mammary fibroblasts (NMFs). We detected global changes in DNA methylation as well as distinct changes in promoter methylation between NMFs and breast CAFs in mice. These changes inversely correlated with transcriptional changes between CAFs and NMFs. We characterized potential regulators of this process, and tested their expression in CAFs in human breast cancer patients, to confirm relevance of our findings to human disease. Our findings suggest that epigenetic alterations contribute to the transcriptional rewiring of fibroblasts to CAFs. This work presents a comprehensive map of DNA-methylation in CAFs, and reveals a previously unknown facet of the dynamic plasticity of the stroma.
    Close abstract

    Melanoma addiction to GCDH defines NRF2 tumor suppressor function

    Date:
    18
    Thursday
    November
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Ze’ev Ronai
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Order from Chaos: Chromosome Catastrophes Drive Cancer Evolution

    Date:
    02
    Tuesday
    November
    2021
    Lecture / Seminar
    Time: 10:00-11:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Dr. Ofer Shoshani
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: Chromosomal instability is one of the major hallmarks in cancer driving numerica ... Read more Chromosomal instability is one of the major hallmarks in cancer driving numerical and structural chromosome aberrations. Cancer cells can use the chaotic background of chromosome instability to generate ordered genomic events leading to accelerated tumor formation or drug resistance. I will show how chromothripsis, the catastrophic shattering of a chromosome and random religation of its pieces, can promote resistance to therapy. Using cancer cells and patient samples, I identified that chromothripsis drives the formation and evolution of extrachromosomal DNA (ecDNA) elements that can amplify genes conferring drug resistance. I will then discuss how transient centrosome amplification can induce a burst of chromosomal instability in vivo. This triggers the formation of random aneuploidies (changes in chromosome numbers) with cancer initiating cells carrying a specific aneuploidy signature leading to accelerated tumorigenesis. This work has uncovered aneuploidy as a direct driver of cancer and enables a better understanding of the involvement of specific aneuploidies in cancer.
    Close abstract

    Modeling and targeting cancer aneuploidy

    Date:
    07
    Thursday
    October
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Uri Ben-David
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    SCANnTREAT: photodynamic therapy triggered by spectral scanner CT: an new tool for cancer treatment?

    Date:
    30
    Thursday
    September
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Prof. Philippe DOUEK
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Special seminar with Dr. Yaara Oren

    Date:
    16
    Monday
    August
    2021
    Lecture / Seminar
    Time: 15:00-16:00
    Title: Beyond Darwin: understanding cancer persister cells
    Lecturer: Dr. Yaara Oren
    Organizer: Department of Molecular Genetics
    Contact: sandra.britton@weizmann.ac.il
    Details: zoom: https://weizmann.zoom.us/j/96160519106?pwd=ZSs0NXd0WWZSaTBQTTRxSkZ5dmRvdz09
    Abstract: Despite favorable initial response to therapy, a third of cancer patients will d ... Read more Despite favorable initial response to therapy, a third of cancer patients will develop recurrent disease and succumb to it within five years of diagnosis. While there has been much progress in characterizing the pathways that contribute to stable genetic drug resistance, the mechanisms underlying early reversible resistance, also known as persisters-driven resistance, remain largely unknown. It has long been believed that persisters represent a subset of cells that happen to be non-proliferating at the time of treatment, and therefore can survive drugs that preferentially kill rapidly proliferating cells. However, in my talk I will describe a rare persister population which, despite not harboring any resistance-conferring mutation, can maintain proliferative capacity in the presence of drug. To study this rare, transiently-resistant, cycling persister population, we developed Watermelon, a high-complexity expressed barcode lentiviral library for simultaneous tracing of each cell’s clonal origin and proliferative and transcriptional states. We combine single cell transcriptomics with imaging and metabolomics to show that cycling and non-cycling persisters arise from different cell lineages with distinct transcriptional and metabolic programs. Finally, I will describe how by studying persister cells we can gain critical insights on cellular memory, fate, and evolution, which can guide the development of better anti-cancer treatments.
    Close abstract

    Imm Guest Seminar: Dr. Yael David will lecture on " Uncovering Cancer-Associated Epigenetic Events Using Novel Chemical Tools."

    Date:
    22
    Thursday
    July
    2021
    Lecture / Seminar
    Time: 11:00-12:00
    Location: Wolfson Building for Biological Research
    Lecturer: Dr. Yael David
    Organizer: Department of Systems Immunology
    Contact: reut.cohen@weizmann.ac.il
    Details: Light refreshments will be served at 10:40.

    Special Guest Seminar

    Date:
    12
    Monday
    July
    2021
    Lecture / Seminar
    Time: 15:00-16:30
    Title: Beyond Darwin: understanding cancer persister cells
    Lecturer: Dr. Yaara Oren
    Organizer: Life Sciences
    Contact: lili.kasumov@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/97339959821?pwd=QkloVEFNVGMwWjlzMWRrSTQyMUZhQT09

    Love the neighbor – Unraveling the tumor microenvironment using multiplexed imaging

    Date:
    08
    Thursday
    July
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Dr. Leeat Keren
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Single Cell Atlases as Roadmaps in Pediatric Cancer

    Date:
    24
    Thursday
    June
    2021
    Lecture / Seminar
    Time: 16:00-17:00
    Lecturer: Prof. Aviv Regev
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    The success and challenges of introducing PARP inhibitors into the therapy of ovarian cancer- a clinician’s perspective

    Date:
    17
    Thursday
    June
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Location: Max and Lillian Candiotty Building
    Lecturer: Prof. Jonathan A Ledermann BSc MD FRCP FMedSci
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    GOING TO EXTREMES: STUDIES WITH RARE EXCEPTIONAL SURVIVORS OF OVARIAN CANCER.

    Date:
    10
    Thursday
    June
    2021
    Lecture / Seminar
    Time: 09:00-10:00
    Lecturer: Prof. David Bowtell
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    New Experimental Methods in Cancer Research - Workshop

    Date:
    31
    Monday
    May
    2021
    Lecture / Seminar
    Time: 08:00-17:00
    Location: Max and Lillian Candiotty Building
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Breast tumor evolution

    Date:
    26
    Wednesday
    May
    2021
    Lecture / Seminar
    Time: 15:00-16:00
    Lecturer: Prof. Kornelia Polyak
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    The two faces of NF-ĸB – the ‘canonical’ tumor promoter and the ‘non-canonical’ tumor suppressor

    Date:
    13
    Thursday
    May
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Prof. Aaron Ciechanover
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Clinical development of mRNA vaccines and therapeutics: COVID and beyond

    Date:
    09
    Sunday
    May
    2021
    Lecture / Seminar
    Time: 09:15-10:00
    Location: Michael Sela Adutitorium
    Lecturer: Dr. Tal Zaks
    Contact: andrea.shveika@weizmann.ac.il
    Details: Zoom link: https://weizmann.zoom.us/j/94905298503
    Abstract: mRNA based vaccines prevent COVID-19 infections, putting them at the forefront o ... Read more mRNA based vaccines prevent COVID-19 infections, putting them at the forefront of the current global fight against the COVID-19 pandemic. The scientific and clinical development of mRNA medicines, which began in ernest only ~10 years ago, has the potential to not only change the landscape of infectious disease vaccines but to also impact the treatment of cancer, genetic metabolic, autoimmune, and cardiovascular diseases. This talk will review the translational medicine approach to the research and development of both infectious disease vaccines, as exemplified by COVID-19 vaccine Moderna, as well as other applications of mRNA medicines currently in clinical development. ᐧ
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    Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

    Date:
    27
    Tuesday
    April
    2021
    Lecture / Seminar
    Time: 10:00-11:00
    Location: Nella and Leon Benoziyo Building for Biological Sciences
    Lecturer: Oshrat Galibov-Levi
    Organizer: Department of Biomolecular Sciences
    Contact: levana.ayvazo@weizmann.ac.il
    Abstract: In the colon, long-term exposure to chronic inflammation drives colitis-associat ... Read more In the colon, long-term exposure to chronic inflammation drives colitis-associated colon cancer (CAC). However, molecular understanding of how this occurs is still lacking. Within the tumor, cancer cells are surrounded by a variety of non-malignant cells and by the extracellular matrix (ECM), which together compose the tumor microenvironment (TME), which is essential for tumor homeostasis and progression. While the cancer cells are highly mutated, the stromal cells are genomically stable. Master regulator heat shock factor 1 (HSF1) was shown to play an important part in the transcriptional reprogramming of the TME. By using proteomic and advanced methods of microscopy and image analysis we show that HSF1-dependent ECM remodeling plays a crucial role in mediating inflammation-driven colon cancer. /j/95881429481?pwd=VkxwUmg1Z2ErZmhpZDJqMTZwellGZz09
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    Therapeutic Exploitation of Metabolic Vulnerabilities of Cancer

    Date:
    22
    Thursday
    April
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Prof. Eyal Gottlieb
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Inactivation of DNA repair and high dose Vitamin C boost cancer immunotherapy

    Date:
    08
    Thursday
    April
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Prof. Alberto Bardelli
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    VEGF/vascular-centered view of the tumor microenvironment and aging

    Date:
    25
    Thursday
    March
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Prof. Eli Keshet
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Inflammation, Metabolism and Immunity in Liver Cancer: From Pathogenesis to Treatment

    Date:
    04
    Thursday
    March
    2021
    Lecture / Seminar
    Time: 09:00-10:00
    Lecturer: Dr. Michael Karin
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Proteasome profiling meets precision oncology

    Date:
    18
    Thursday
    February
    2021
    Lecture / Seminar
    Time: 14:00
    Lecturer: Dr. Yifat Merbl
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Targeted protein degradation for the treatment of cancer

    Date:
    04
    Thursday
    February
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Benjamin Ebert, MD, PhD
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Studying resistance in cancer

    Date:
    28
    Thursday
    January
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Prof. Getz Gad
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Quantitative Prediction of Nanoparticle Assembly for Personalized Nanomedicine

    Date:
    17
    Sunday
    January
    2021
    Lecture / Seminar
    Time: 11:00-12:00
    Lecturer: Prof. Yosi Shamay
    Organizer: Department of Molecular Chemistry and Materials Science
    Contact: ana.naamat@weizmann.ac.il
    Abstract: Zoom Link: https://weizmann.zoom.us/j/92447973616?pwd=UWJkRWdraGFVQjdPb3ByWis1b ... Read more Zoom Link: https://weizmann.zoom.us/j/92447973616?pwd=UWJkRWdraGFVQjdPb3ByWis1bDk2Zz09 Development of targeted nanoparticle for personalized cancer therapeutics often requires complex synthetic schemes involving both supramolecular self-assembly and multiple chemical modifications. These processes are generally difficult to predict, execute, and control. I will describe a new method to accurately and quantitatively predict self-assembly of kinase inhibitors drug molecules into nanoparticles based on their molecular structures. The drugs assemble with the aid of new kind of excipient comprised of highly conjugated sulfated molecule into particles with ultra-high drug loadings of up to 90%. Using quantitative structure-nanoparticle assembly prediction (QSNAP) calculations and machine learning, a new algorithm was developed as highly predictive indicators of both nano-self assembly and nanoparticle size with unprecedented accuracy.
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    Molecular mechanisms of senescence on the crossroads of cancer and aging

    Date:
    14
    Thursday
    January
    2021
    Lecture / Seminar
    Time: 14:00-15:00
    Lecturer: Prof. Valery Krizhanovsky
    Organizer: Dwek Institute for Cancer Therapy Research
    Contact: michal.av@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    Special Guest Seminar

    Date:
    11
    Monday
    January
    2021
    Lecture / Seminar
    Time: 16:00-17:30
    Title: "Dietary sulfur amino acids modulate kidney function and anti-tumor immunity via the gut microbiota"
    Lecturer: Dr. Lior Lobel
    Organizer: Life Sciences
    Contact: lili.kasumov@weizmann.ac.il
    Details: https://weizmann.zoom.us/j/96460895671?pwd=VktPaXNSR3lyNUVBZktzRnB3Rys5UT09 Mee ... Read more https://weizmann.zoom.us/j/96460895671?pwd=VktPaXNSR3lyNUVBZktzRnB3Rys5UT09 Meeting ID: 964 6089 5671 Password: 599560
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    PCR-free sensing of Covid-19, metastatic mRNA biomarkers and towards single-cell proteomic

    Date:
    03
    Sunday
    January
    2021
    Lecture / Seminar
    Time: 11:00-12:00
    Lecturer: Prof. Amit Meller
    Organizer: Department of Molecular Chemistry and Materials Science
    Contact: ana.naamat@weizmann.ac.il
    Abstract: Zoom Link: https://weizmann.zoom.us/j/98521602060?pwd=T1B1TEJqcXEwUW50QzBEaXd3R ... Read more Zoom Link: https://weizmann.zoom.us/j/98521602060?pwd=T1B1TEJqcXEwUW50QzBEaXd3RS9XZz09 SARS-CoV-2 outbreak of the coronavirus disease (COVID-19) has underlined the acute need for extremely sensitive, accurate, fast, point-of-care mRNA quantification sensors. Here I will show how solid-state nanopores can be used to digitally count target mRNA molecules from both biological and clinical Covid-19 samples surpassing the accuracy and gold-standard” RT-qPCR. Additionally, we applied our method for the sensing of cancer metastatic mRNA biomarkers MACC1 and S100A4 at early stage of the diseases, suggesting a potential use of the method in early precision medicine diagnostics. Moving beyond nucleic acids, I will discuss our on-going efforts towards the use of plasmonic nanopore devices for the single protein molecules identification based on partial labelling of only two or three amino acids. This research opens up vast directions for single-cell proteomics of even rarely expressed proteins.
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