Establishing a Centralized Repository of Tumor Models
The WIS Tumor Bank is a developing institutional resource designed to support cancer research across the Weizmann Institute. Our objective is to establish a shared repository of validated cancer cell lines and mouse tumor models generated by Weizmann laboratories. This centralized platform aims to facilitate access to high-quality models, promote collaboration between research groups, and streamline the sharing of biological materials.
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
About the Repository
We are currently in the process of collecting cell lines for inclusion in the Tumor Bank. Our goal is to develop a comprehensive repository comprising:
- Approximately 150 cancer cell lines (currently stored ~100 cell lines)
- Stored in liquid nitrogen tanks
- Validated by fingerprinting and mycoplasma testing
- Analyzed by RNA sequencing (RNA-seq)
- A subset of approximately 100 cell lines will be used to generate subcutaneous mouse tumor models, which will be:
- Analyzed by both RNA-seq and exome sequencing
- Documented with tumor growth curves
- Preserved as FFPE blocks, H&E stained, and digitally scanned
All data generated through this initiative will be made available to the Weizmann scientific community.
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Benefits of Contributing Cell Lines
We invite laboratories across the institute to contribute to the Tumor Bank. Participating labs will receive:
- Three frozen vials in return for each vial deposited
- Free validation (fingerprinting and mycoplasma testing) and RNA-seq analysis of contributed cell lines
- Credit points toward future orders from the repository
- Simplified processes for sharing models between research groups
- An opportunity to contribute to a collaborative and valuable institutional resource
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
How to Contribute a cell line?
To contribute, please complete the cell line submission table and email it to:
roni.oren@weizmann.ac.il
The Tumor Bank team will coordinate collection, storage, and analysis.
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Accessing Cell Lines
Weizmann researchers can consult the Tumor Bank database to identify available models. All models will remain the property of the contributing laboratory. Requesting a cell line can be done via the link:
Access the Cell Line Request Page https://prodis.weizmann.ac.il/pls/htmldb/r/ws1/451/12
Upon request submission, the contributing PI will receive an email to approve or reject the request. Only after approval will the cells be distributed, and a handling fee will be charged.
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Tumor Bank Team
Prof. Ravid Straussman – Scientific Director, WIS–Brazil Tumor Bank
Dr. Roni Oren – Head, Cancer Models Unit
Polina Gradchenko – Research Assistant
Avivit Atias – Research Assistant
For inquiries or further information, please contact:
roni.oren@weizmann.ac.il