Deciphering spatial organization of the extracellular matrix in glioblastoma

The extracellular matrix (ECM) is a complex network of proteins and carbohydrates that plays an active role in influencing crucial aspects of cancer biology such as progression, invasion, and drug resistance. We recently established a spatial proteomics approach to map the cell states in glioblastoma at single-cell resolution. We now want to extend this platform to also comprehensively profile the composition and spatial patterns of the ECM. Our goal is to understand the interaction between the ECM, cancer cell states, and non-cancer cells of the tumor microenvironment and how this interplay leads to cancer progression and invasion.