We hypothesize that mechanisms underlying cell size regulation in normal cells are diverted to survival/death pathways in cancer cells, raising the prospect of selectively targeting such mechanisms as a therapeutic strategy. Identifying key hubs in intracellular networks that may shift a size-sensing mechanism to control of proliferation or survival is likely to open new avenues for therapeutic development in the future.
Grant type:
Grant scientist:
Mike Fainzilber
Grant year:
2018